MCID: ETH009
MIFTS: 37

Ethmoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Ethmoid Sinusitis

MalaCards integrated aliases for Ethmoid Sinusitis:

Name: Ethmoid Sinusitis 12 44 15 17 72
Ethmoidal Sinusitis 12
Ethmoiditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9507
MeSH 44 D015521
NCIt 50 C34597
SNOMED-CT 68 18643000
ICD10 33 J32.2
UMLS 72 C0015029

Summaries for Ethmoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead.

MalaCards based summary : Ethmoid Sinusitis, also known as ethmoidal sinusitis, is related to chronic ethmoiditis and paranasal sinus disease. An important gene associated with Ethmoid Sinusitis is MUC7 (Mucin 7, Secreted), and among its related pathways/superpathways are Innate Immune System and CLEC7A (Dectin-1) signaling. The drugs Hyaluronic acid and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and breast.

Related Diseases for Ethmoid Sinusitis

Diseases related to Ethmoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 492)
# Related Disease Score Top Affiliating Genes
1 chronic ethmoiditis 32.2 MUC7 MUC6 MUC5B MUC5AC MUC4 MUC1
2 paranasal sinus disease 32.0 RHNO1 MUC5B
3 maxillary sinusitis 30.9 RHNO1 MUC5B
4 rhinoscleroma 30.6 RHNO1 DCXR
5 frontal sinusitis 30.6 RHNO1 DCXR
6 subdural empyema 30.6 MUC5B CRP
7 sphenoid sinusitis 30.5 RHNO1 CRP
8 mastoiditis 30.3 RHNO1 CRP
9 orbital cellulitis 30.3 RHNO1 CRP
10 signet ring cell adenocarcinoma 30.2 MUC6 MUC1
11 mucormycosis 30.1 RHNO1 CSF2
12 orbital disease 30.1 RHNO1 CRP
13 microcystic adenoma 30.1 MUC6 MUC1
14 cystadenoma 29.7 MUC6 MUC4 MUC1
15 mucoepidermoid carcinoma 29.5 MUC5AC MUC4 MUC1
16 middle ear disease 29.4 PRTN3 MUC5B MUC5AC
17 chronic maxillary sinusitis 28.8 RHNO1 PRTN3 MUC5B MUC5AC
18 ethmoid sinus squamous cell carcinoma 12.6
19 acute ethmoiditis 12.4
20 ethmoid sinus inverted papilloma 12.4
21 ethmoid sinus adenoid cystic carcinoma 12.3
22 ethmoidal sinus neoplasm 12.2
23 ethmoid sinus schneiderian papilloma 12.2
24 ethmoid sinus ectopic meningioma 12.2
25 meningoencephalocele 11.6
26 olfactory neuroblastoma 11.4
27 neurogenic bowel 10.6 KIDINS220 DCXR
28 diverticulitis 10.5 DCXR CRP
29 rhinosporidiosis 10.5 RHNO1 DCXR
30 parasitic ichthyosporea infectious disease 10.5 RHNO1 DCXR
31 anus disease 10.5 KIDINS220 DCXR
32 adenocarcinoma 10.4
33 rectal disease 10.4 KIDINS220 DCXR
34 ossifying fibroma 10.4
35 tn polyagglutination syndrome 10.4 MUC7 MUC1
36 meningioma, radiation-induced 10.4
37 meningioma, familial 10.4
38 spinal meningioma 10.4
39 secretory meningioma 10.4
40 lymphoplasmacyte-rich meningioma 10.4
41 sarcoma 10.4
42 spindle cell sarcoma 10.4
43 cryptogenic organizing pneumonia 10.4 MUC5B MUC1
44 encephalocele 10.4
45 sarcomatoid mesothelioma 10.4 MUC4 MUC1
46 yemenite deaf-blind hypopigmentation syndrome 10.4
47 pancreatic intraductal papillary-mucinous neoplasm 10.3 MUC6 MUC1
48 tumor of exocrine pancreas 10.3 MUC6 MUC1
49 aneurysmal bone cysts 10.3
50 fibrous dysplasia 10.3

Graphical network of the top 20 diseases related to Ethmoid Sinusitis:



Diseases related to Ethmoid Sinusitis

Symptoms & Phenotypes for Ethmoid Sinusitis

Drugs & Therapeutics for Ethmoid Sinusitis

Drugs for Ethmoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
3 Anti-Allergic Agents Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Dermatologic Agents Phase 4
6
Ofloxacin Approved Phase 3 82419-36-1 4583
7
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
8 Anti-Bacterial Agents Phase 3
9 Antibiotics, Antitubercular Phase 3
10 Cytochrome P-450 Enzyme Inhibitors Phase 3
11 Renal Agents Phase 3
12 Antitubercular Agents Phase 3
13 Topoisomerase Inhibitors Phase 3
14 Anti-Infective Agents Phase 3
15 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
16 Anti-Infective Agents, Urinary Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Multi-Center, Randomized, Controlled, Subject-Blinded Study to Evaluate the Safety and Effectiveness of AdvaCoat Sinus Gel Following Endoscopic Ethmoid Sinus Surgery Completed NCT00554190 Phase 4
2 The PIO II Study: A Randomized, Controlled, Blinded Trial to Evaluate the Safety and Efficacy of In-office Placement of a Steroid-eluting Sinus Implant Post-ethmoidectomy Completed NCT02668302 Phase 4
3 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
4 Interventioanl Study of the Sinopsys® Lacrimal Stent in Patients With Moderate to Severe Chronic Rhinosinusitis to Evaluate Safety and Performance for Direct Ethmoid Sinus Saline Irrigation and Ophthalmic Antibiotic/Steroid Delivery Completed NCT03304951
5 The Sinopsys Lacrimal Stent Indicated for Sinus Irrigation Via Transcaruncular Ethmoid Sinus Access in Patients With Moderate to Severe Chronic Rhinosinusitis With Ethmoid Sinus Involvement Completed NCT02297243 Early Phase 1

Search NIH Clinical Center for Ethmoid Sinusitis

Cochrane evidence based reviews: ethmoid sinusitis

Genetic Tests for Ethmoid Sinusitis

Anatomical Context for Ethmoid Sinusitis

MalaCards organs/tissues related to Ethmoid Sinusitis:

41
Eye, Brain, Breast, Bone, Colon, Kidney, Cortex

Publications for Ethmoid Sinusitis

Articles related to Ethmoid Sinusitis:

(show top 50) (show all 293)
# Title Authors PMID Year
1
What Is the Best Treatment for a Subperiosteal Abscess? A Case Report in a Pediatric Patient. 38
30871969 2019
2
Optic Neuropathy, Secondary to Ethmoiditis, and Onodi Cell Inflammation during Childhood: A Case Report and Review of the Literature. 38
31330559 2019
3
Surgical Approaches in the Treatment of Intracranial Complications of Paranasal Sinus Disease: A Review of the Literature. 38
31254711 2019
4
Anesthetic considerations during surgical intervention in Woake's syndrome -a case report. 38
29764007 2019
5
[Acute ethmoid sinusitis complicated by a retrobulbar abscess in a 13-year-old child]. 38
30853144 2019
6
Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis. 38
30651053 2019
7
Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report. 38
30681599 2019
8
Clinical Case Presentation on Absence Seizures Diagnosis and Treatment Care Services and Outcomes in an Adult Patient. 38
30765995 2019
9
Bilateral subdural empyemas with meningitis secondary to acute barosinusitis. 38
30337240 2018
10
Septic Cavernous Sinus Thrombosis Following a Minor Head Injury: A Rare Cause of Medico-Legal Death. 38
29464700 2018
11
Microbiology and antibiotic therapy of subperiosteal orbital abscess in children with acute ethmoiditis. 38
29447900 2018
12
Enhanced Irrigant Delivery to the Ethmoid Sinuses Directly Following Ethmoid Punch Sinusotomy. 38
29047295 2017
13
Antimicrobial treatment of ENT infections. 38
29290238 2017
14
A prospective, randomized clinical study comparing drug eluting stent therapy and intranasal corticoid steroid therapy in the treatment of patients with chronic rhinosinusitis. 38
28492612 2017
15
Safe treatment of ethmoid sinusitis utilizing minimally invasive ethmoid punch sinusotomy in chronic rhinosinusitis without polyposis patients. 38
28194802 2017
16
Metastatic Colon Cancer to the Sphenoid Wing and Ethmoid Sinus Mimicking Orbital Cellulitis: A Rare Presentation. 38
26974420 2017
17
Ethmoiditis with subperiosteal and retro-ocular abscesses due to Aeromonas sobria in a 16-year-old boy exposed to the Ardèche river. 38
28343158 2017
18
Radiologic findings of Fusarium pneumonia in neutropenic patients. 38
27470138 2017
19
The "black evil" affecting patients with diabetes: a case of rhino orbito cerebral mucormycosis causing Garcin syndrome. 38
28405168 2017
20
Primary ciliary dyskinesia presenting with spontaneous pneumothorax: Case report and review of the literature. 38
28616378 2017
21
Topographic relationship; sinusitis and paranasal sinus computed tomography. 38
29553614 2016
22
Trends in chronic rhinosinusitis research in the past three decades. 38
26256105 2016
23
Relationship between dacryoadenitis subtype of idiopathic orbital inflammatory pseudotumor and paranasal sinusitis. 38
27158618 2016
24
Pediatric sinogenic epidural and subdural empyema: The role of endoscopic sinus surgery. 38
26304070 2015
25
Extra middle turbinate lamellas: a suggested new classification. 38
25616850 2015
26
Image-guided, navigation-assisted Relieva Stratus MicroFlow Spacer insertion into the ethmoid sinus. 38
25325931 2015
27
Primary acquired nasolacrimal duct obstruction: is it really related to paranasal abnormalities? 38
25422096 2015
28
Nocardia asteroides sinusitis in a pediatric patient: Case report with 20 year follow-up and review of the literature. 38
25943955 2015
29
Orbital necrotizing fasciitis and osteomyelitis caused by arcanobacterium haemolyticum: a case report. 38
24801256 2015
30
The role of osteitis of the lamina papyracea in the formation of subperiosteal orbital abscess in young children. 38
25465453 2014
31
[Orbital complications of sinusitis]. 38
25640234 2014
32
Primary ciliary dyskinesia complicated with diffuse panbronchiolitis: a case report and literature review. 38
24308375 2014
33
A novel therapeutic use of HFA-BDP metereddose inhaler for asthmatic patients with rhinosinusitis: Case series. 38
25074867 2014
34
Frequency of the odontogenic maxillary sinusitis extended to the anterior ethmoid sinus and response to surgical treatment. 38
24608208 2014
35
Ossifying fibroma of the middle turbinate revealed by infection in a young child. 38
24139075 2014
36
[Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old]. 38
24269390 2014
37
Step-by-step iconographic description of a prolonged but still favourable course of orbital cellulitis in a child with acute rhinosinusitis: an iconographic case study. 38
24594215 2014
38
Neonatal orbital abscess. 38
24008806 2014
39
[Pediatric orbital cellulitis without sinusitis: report of four cases]. 38
24239218 2014
40
[The influence of local and combined acute suppurative Highmore maxillary sinusitis on the serum lactoferrin and interleukin-8 levels in the children]. 38
25588485 2014
41
[Septic cavernous sinus thrombosis following ethmoiditis: a case report]. 38
24290188 2014
42
Inflammation of the frontal intersinus septal air cell as a cause of headaches. 38
25485764 2014
43
[A childhood nasopharyngeal carcinoma with huge mass in skull base]. 38
24459938 2013
44
A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia. 38
23686329 2013
45
Orbital apex syndrome as a sign of unsuspected breast carcinoma. 38
23851836 2013
46
[Endoscopic treatment of orbital cellulitis in pediatric patients: transethmoidal approach]. 38
23768475 2013
47
[Aspergillus ethmoiditis associated with orbital abscess]. 38
23685133 2013
48
[Mucormycosis: an unusual cause of unilateral exophthalmia]. 38
23721996 2013
49
Neonatal orbital abscess. 38
23782382 2013
50
Drainage of subperiosteal orbital abscesses complicating pediatric ethmoiditis: comparison between external and transnasal approaches. 38
23523197 2013

Variations for Ethmoid Sinusitis

Expression for Ethmoid Sinusitis

Search GEO for disease gene expression data for Ethmoid Sinusitis.

Pathways for Ethmoid Sinusitis

GO Terms for Ethmoid Sinusitis

Cellular components related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 PRTN3 MUC7 MUC5B MUC5AC MUC4 MUC1
2 extracellular space GO:0005615 9.7 PRTN3 MUC5B MUC5AC MUC4 MUC1 CSF2
3 extracellular region GO:0005576 9.61 PRTN3 MUC7 MUC6 MUC5B MUC5AC MUC4
4 Golgi lumen GO:0005796 9.1 MUC7 MUC6 MUC5B MUC5AC MUC4 MUC1

Biological processes related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 MUC7 MUC6 MUC5B MUC5AC MUC4 MUC1
2 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC6 MUC4
3 O-glycan processing GO:0016266 9.1 MUC7 MUC6 MUC5B MUC5AC MUC4 MUC1

Sources for Ethmoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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