MCID: ETH009
MIFTS: 37

Ethmoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Ethmoid Sinusitis

MalaCards integrated aliases for Ethmoid Sinusitis:

Name: Ethmoid Sinusitis 12 45 15 17 74
Ethmoidal Sinusitis 12
Ethmoiditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9507
MeSH 45 D015521
NCIt 51 C34597
SNOMED-CT 69 18643000
ICD10 34 J32.2
UMLS 74 C0015029

Summaries for Ethmoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead.

MalaCards based summary : Ethmoid Sinusitis, also known as ethmoidal sinusitis, is related to chronic ethmoiditis and paranasal sinus disease. An important gene associated with Ethmoid Sinusitis is MUC7 (Mucin 7, Secreted), and among its related pathways/superpathways are Innate Immune System and CLEC7A (Dectin-1) signaling. The drugs Hyaluronic acid and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and pancreas.

Related Diseases for Ethmoid Sinusitis

Diseases related to Ethmoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 chronic ethmoiditis 32.5 MUC1 MUC4 MUC5AC MUC5B MUC6 MUC7
2 paranasal sinus disease 32.3 MUC5B RHNO1
3 orbital cellulitis 30.6 CRP RHNO1
4 frontal sinusitis 30.5 DCXR RHNO1
5 maxillary sinusitis 30.5 MUC5B RHNO1
6 subdural empyema 30.2 CRP MUC5B
7 rhinoscleroma 30.1 DCXR RHNO1
8 signet ring cell adenocarcinoma 30.0 MUC1 MUC6
9 mastoiditis 30.0 CRP RHNO1
10 sphenoid sinusitis 29.9 CRP RHNO1
11 microcystic adenoma 29.8 MUC1 MUC6
12 mucormycosis 29.8 CSF2 RHNO1
13 cystadenoma 29.8 MUC1 MUC4 MUC6
14 mucoepidermoid carcinoma 29.2 MUC1 MUC4 MUC5AC
15 ethmoid sinus adenocarcinoma 12.5
16 ethmoid sinus squamous cell carcinoma 12.4
17 ethmoid sinus cancer 12.4
18 acute ethmoiditis 12.3
19 ethmoid sinus inverted papilloma 12.2
20 ethmoid sinus adenoid cystic carcinoma 12.2
21 ethmoidal sinus neoplasm 12.1
22 ethmoid sinus schneiderian papilloma 12.1
23 ethmoid sinus ectopic meningioma 12.1
24 meningoencephalocele 11.4
25 olfactory neuroblastoma 11.3
26 sinusitis 10.7
27 parasitic ichthyosporea infectious disease 10.4 DCXR RHNO1
28 rhinosporidiosis 10.4 DCXR RHNO1
29 ossifying fibroma 10.4
30 orbital disease 10.3 CRP RHNO1
31 tn polyagglutination syndrome 10.2 MUC1 MUC7
32 fibrous dysplasia 10.2
33 arteriovenous fistula 10.2
34 diverticulitis 10.2 CRP DCXR
35 sinus cancer 10.2
36 cryptogenic organizing pneumonia 10.2 MUC1 MUC5B
37 acute orbital inflammation 10.2 CRP RHNO1
38 sarcomatoid mesothelioma 10.2 MUC1 MUC4
39 tumor of exocrine pancreas 10.2 MUC1 MUC6
40 pancreatic intraductal papillary-mucinous neoplasm 10.2 MUC1 MUC6
41 intracranial abscess 10.2 CRP TWIST1
42 lymphoma 10.2
43 aneurysmal bone cysts 10.2
44 osteoblastoma 10.2
45 encephalocele 10.2
46 appendix cancer 10.2 MUC1 MUC6
47 duodenum cancer 10.1 MUC1 MUC6
48 bronchiolo-alveolar adenocarcinoma 10.1 MUC4 MUC6
49 orbital granuloma 10.1 MUC1 PRTN3
50 mixed ductal-endocrine carcinoma 10.1 MUC1 MUC6

Graphical network of the top 20 diseases related to Ethmoid Sinusitis:



Diseases related to Ethmoid Sinusitis

Symptoms & Phenotypes for Ethmoid Sinusitis

Drugs & Therapeutics for Ethmoid Sinusitis

Drugs for Ethmoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
3 Anti-Inflammatory Agents Phase 4
4 Anti-Allergic Agents Phase 4
5 Dermatologic Agents Phase 4
6
Ofloxacin Approved Phase 3 82419-36-1 4583
7
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
8 Anti-Bacterial Agents Phase 3,Not Applicable
9 Antibiotics, Antitubercular Phase 3,Not Applicable
10 Anti-Infective Agents, Urinary Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 3
12 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
13 Antitubercular Agents Phase 3
14 Topoisomerase Inhibitors Phase 3
15 Renal Agents Phase 3
16 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
2 The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant Completed NCT02668302 Phase 4
3 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
4 Sinopsys® Lacrimal Stent Indicated for Sinus Irrigation Completed NCT03304951 Not Applicable
5 Sinopsys Lacrimal Stent Indicated for Sinus Irrigation Completed NCT02297243 Early Phase 1

Search NIH Clinical Center for Ethmoid Sinusitis

Cochrane evidence based reviews: ethmoid sinusitis

Genetic Tests for Ethmoid Sinusitis

Anatomical Context for Ethmoid Sinusitis

MalaCards organs/tissues related to Ethmoid Sinusitis:

42
Eye, Bone, Pancreas, Prostate, B Cells, Brain, Heart

Publications for Ethmoid Sinusitis

Articles related to Ethmoid Sinusitis:

(show all 33)
# Title Authors Year
1
Superior divisional oculomotor nerve palsy caused by fronto-ethmoidal sinusitis. ( 30119806 )
2018
2
Distinguishing the dominant species of pathogen in ethmoidal sinusitis by sequencing DNA dataset analysis. ( 30402160 )
2018
3
Safe treatment of ethmoid sinusitis utilizing minimally invasive ethmoid punch sinusotomy in chronic rhinosinusitis without polyposis patients. ( 28194802 )
2017
4
[Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old]. ( 24269390 )
2014
5
Ethmoidal sinusitis caused by Exserohilum rostratum in a patient with malignant lymphoma after non-myeloablative allogeneic peripheral blood stem cell transplantation. ( 17462000 )
2007
6
Malignant ethmoid sinus tumor masquerading as chronic ethmoid sinusitis. ( 17240703 )
2006
7
Bacteriology of acute and chronic ethmoid sinusitis. ( 16000483 )
2005
8
Microbiology of chronic ethmoid sinusitis: is this a bacterial disease? ( 15547805 )
2004
9
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. ( 15472353 )
2004
10
Painful postganglionic Horners syndrome caused by ethmoid sinusitis. ( 15330830 )
2004
11
Peripheral scotoma associated with chronic ethmoidal sinusitis. A case report and review of the literature. ( 9695165 )
1998
12
Cerebral venous thrombosis associated with maxillary and ethmoid sinusitis--a case report. ( 8750066 )
1995
13
Bilateral ethmoid sinusitis with unilateral proptosis as an initial manifestation of metastatic prostate carcinoma. ( 7861473 )
1994
14
Chronic ethmoidal sinusitis. ( 8483379 )
1993
15
Relationship of chronic ethmoidal sinusitis, maxillary sinusitis, and ostial permeability controlled by sinusomanometry: statistical study. ( 1405991 )
1992
16
Radiological case of the month. Subperiosteal orbital abscess and ethmoid sinusitis. ( 1456261 )
1992
17
Evaluation of the microbiology of chronic ethmoid sinusitis. ( 1774242 )
1991
18
Clinical radiology quiz. Ethmoid sinusitis that lead to orbital and preseptal cellulitis. ( 1928603 )
1991
19
Bilateral consecutive superior oblique palsy following fronto-ethmoidal sinusitis. ( 2246734 )
1990
20
Subdural empyema complicating frontal and ethmoid sinusitis. ( 2564381 )
1989
21
CT diagnosis of occult anterior ethmoid sinusitis in a case of lacrimal sac abscess. ( 3262299 )
1988
22
Brain abscess and ethmoid sinusitis presenting as periorbital cellulitis in a two-month-old infant. ( 3562144 )
1987
23
Fallibility of sinus radiographs in demonstrating ethmoid sinusitis. ( 3616799 )
1987
24
Radical surgical treatment for extensive chronic fronto-ethmoidal sinusitis. ( 3794540 )
1986
25
Orbital abscess secondary to ethmoidal sinusitis. ( 6605846 )
1983
26
Chronic ethmoid sinusitis due to foreign body. ( 7343837 )
1981
27
Complications of frontal and ethmoid sinusitis. ( 7359985 )
1980
28
Acute Frontal and Ethmoid Sinusitis with Subperiosteal Abscess. ( 29265274 )
1972
29
Acute frontal and ethmoid sinusitis with subperiosteal abscess. ( 5255101 )
1969
30
Ethmoid sinusitis in children. ( 13615441 )
1958
31
[Ethmoid sinusitis in infant]. ( 13217824 )
1954
32
Sphenoidal and Ethmoidal Sinusitis with Hemianopsia. ( 19989381 )
1933
33
Case of Labyrinthine Vertigo due to Sphenoidal and Ethmoidal Sinusitis. ( 19983931 )
1924

Variations for Ethmoid Sinusitis

Expression for Ethmoid Sinusitis

Search GEO for disease gene expression data for Ethmoid Sinusitis.

Pathways for Ethmoid Sinusitis

GO Terms for Ethmoid Sinusitis

Cellular components related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 DCXR MUC1 MUC4 MUC5AC MUC5B MUC7
2 extracellular space GO:0005615 9.7 CRP CSF2 MUC1 MUC4 MUC5AC MUC5B
3 extracellular region GO:0005576 9.61 CRP CSF2 MUC1 MUC4 MUC5AC MUC5B
4 Golgi lumen GO:0005796 9.1 MUC1 MUC4 MUC5AC MUC5B MUC6 MUC7

Biological processes related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 CSF2 MUC1 PRTN3 TWIST1
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 MUC1 MUC4 MUC5AC MUC5B MUC6 MUC7
3 maintenance of gastrointestinal epithelium GO:0030277 9.26 MUC4 MUC6
4 O-glycan processing GO:0016266 9.1 MUC1 MUC4 MUC5AC MUC5B MUC6 MUC7

Sources for Ethmoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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