MCID: ETH009
MIFTS: 37

Ethmoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Ethmoid Sinusitis

MalaCards integrated aliases for Ethmoid Sinusitis:

Name: Ethmoid Sinusitis 12 44 15 73
Ethmoidal Sinusitis 12
Ethmoiditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9507
ICD10 33 J32.2
MeSH 44 D015521
NCIt 50 C34597
SNOMED-CT 68 18643000
UMLS 73 C0015029

Summaries for Ethmoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead.

MalaCards based summary : Ethmoid Sinusitis, also known as ethmoidal sinusitis, is related to chronic ethmoiditis and paranasal sinus disease. An important gene associated with Ethmoid Sinusitis is MUC7 (Mucin 7, Secreted), and among its related pathways/superpathways are Innate Immune System and Metabolism of proteins. The drugs Hyaluronic acid and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and bone.

Related Diseases for Ethmoid Sinusitis

Diseases related to Ethmoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 chronic ethmoiditis 32.4 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
2 paranasal sinus disease 32.0 MUC5B RHNO1
3 orbital cellulitis 30.5 CRP RHNO1
4 frontal sinusitis 30.3 DCXR RHNO1
5 maxillary sinusitis 30.3 MUC5B RHNO1
6 subdural empyema 30.1 CRP MUC5B
7 signet ring cell adenocarcinoma 30.0 MUC1 MUC2 MUC6
8 rhinoscleroma 29.9 DCXR RHNO1
9 mastoiditis 29.8 CRP RHNO1
10 sphenoid sinusitis 29.8 CRP RHNO1
11 microcystic adenoma 29.7 MUC1 MUC6
12 papillary adenocarcinoma 29.6 MUC1 MUC2
13 otitis media 29.4 MUC2 MUC5AC MUC5B
14 ethmoid sinus adenocarcinoma 12.5
15 ethmoid sinus cancer 12.4
16 ethmoid sinus squamous cell carcinoma 12.4
17 acute ethmoiditis 12.2
18 ethmoid sinus inverted papilloma 12.2
19 ethmoid sinus adenoid cystic carcinoma 12.1
20 ethmoid sinus schneiderian papilloma 12.1
21 ethmoid sinus ectopic meningioma 12.0
22 meningoencephalocele 11.4
23 olfactory neuroblastoma 11.2
24 sinusitis 10.7
25 ossifying fibroma 10.3
26 parasitic ichthyosporea infectious disease 10.3 DCXR RHNO1
27 rhinosporidiosis 10.3 DCXR RHNO1
28 small intestine adenocarcinoma 10.2 MUC2 MUC6
29 duodenum adenocarcinoma 10.2 MUC2 MUC6
30 appendix disease 10.2 MUC2 MUC6
31 tubular adenocarcinoma 10.2 MUC1 MUC2
32 orbital disease 10.2 CRP RHNO1
33 sinus cancer 10.2
34 cystic teratoma 10.2 MUC2 MUC6
35 cryptogenic organizing pneumonia 10.2 MUC1 MUC5B
36 mucormycosis 10.2 CSF2 RHNO1
37 diverticulitis 10.2 CRP DCXR
38 intracranial abscess 10.1 CRP TWIST1
39 ampulla of vater adenocarcinoma 10.1 MUC1 MUC2
40 osteoblastoma 10.1
41 fibrous dysplasia 10.1
42 encephalocele 10.1
43 mucinous cystadenocarcinoma 10.1 MUC1 MUC2
44 acute orbital inflammation 10.1 CRP RHNO1
45 bronchiolo-alveolar adenocarcinoma 10.1 MUC2 MUC4 MUC6
46 burns 10.1 CRP CSF2
47 orbital granuloma 10.1 MUC1 PRTN3
48 neutrophilia, hereditary 10.1 CRP CSF2
49 mixed ductal-endocrine carcinoma 10.1 MUC1 MUC6
50 aneurysmal bone cysts 10.1

Graphical network of the top 20 diseases related to Ethmoid Sinusitis:



Diseases related to Ethmoid Sinusitis

Symptoms & Phenotypes for Ethmoid Sinusitis

Drugs & Therapeutics for Ethmoid Sinusitis

Drugs for Ethmoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
mometasone furoate Approved, Vet_approved Phase 4 83919-23-7
3 Dermatologic Agents Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Allergic Agents Phase 4
6
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
7
Ofloxacin Approved Phase 3 82419-36-1 4583
8 Antibiotics, Antitubercular Phase 3,Not Applicable
9 Anti-Bacterial Agents Phase 3,Not Applicable
10 Antitubercular Agents Phase 3
11 Topoisomerase Inhibitors Phase 3
12 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
13 Renal Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Cytochrome P-450 Enzyme Inhibitors Phase 3
16 Anti-Infective Agents, Urinary Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
2 The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant Completed NCT02668302 Phase 4
3 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
4 Sinopsys® Lacrimal Stent Indicated for Sinus Irrigation Completed NCT03304951 Not Applicable
5 Sinopsys Lacrimal Stent Indicated for Sinus Irrigation Completed NCT02297243 Early Phase 1

Search NIH Clinical Center for Ethmoid Sinusitis

Cochrane evidence based reviews: ethmoid sinusitis

Genetic Tests for Ethmoid Sinusitis

Anatomical Context for Ethmoid Sinusitis

MalaCards organs/tissues related to Ethmoid Sinusitis:

41
Eye, Lung, Bone, Breast, Pancreas, Small Intestine, Appendix

Publications for Ethmoid Sinusitis

Articles related to Ethmoid Sinusitis:

(show all 32)
# Title Authors Year
1
Superior divisional oculomotor nerve palsy caused by fronto-ethmoidal sinusitis. ( 30119806 )
2018
2
Distinguishing the dominant species of pathogen in ethmoidal sinusitis by sequencing DNA dataset analysis. ( 30402160 )
2018
3
Safe treatment of ethmoid sinusitis utilizing minimally invasive ethmoid punch sinusotomy in chronic rhinosinusitis without polyposis patients. ( 28194802 )
2017
4
Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old. ( 24269390 )
2012
5
Ethmoidal sinusitis caused by Exserohilum rostratum in a patient with malignant lymphoma after non-myeloablative allogeneic peripheral blood stem cell transplantation. ( 17462000 )
2007
6
Malignant ethmoid sinus tumor masquerading as chronic ethmoid sinusitis. ( 17240703 )
2006
7
Bacteriology of acute and chronic ethmoid sinusitis. ( 16000483 )
2005
8
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. ( 15472353 )
2004
9
Painful postganglionic Horners syndrome caused by ethmoid sinusitis. ( 15330830 )
2004
10
Microbiology of chronic ethmoid sinusitis: is this a bacterial disease? ( 15547805 )
2004
11
Cerebral venous thrombosis associated with maxillary and ethmoid sinusitis--a case report. ( 8750066 )
1995
12
Bilateral ethmoid sinusitis with unilateral proptosis as an initial manifestation of metastatic prostate carcinoma. ( 7861473 )
1994
13
Chronic ethmoidal sinusitis. ( 8483379 )
1993
14
Radiological case of the month. Subperiosteal orbital abscess and ethmoid sinusitis. ( 1456261 )
1992
15
Relationship of chronic ethmoidal sinusitis, maxillary sinusitis, and ostial permeability controlled by sinusomanometry: statistical study. ( 1405991 )
1992
16
Clinical radiology quiz. Ethmoid sinusitis that lead to orbital and preseptal cellulitis. ( 1928603 )
1991
17
Evaluation of the microbiology of chronic ethmoid sinusitis. ( 1774242 )
1991
18
Bilateral consecutive superior oblique palsy following fronto-ethmoidal sinusitis. ( 2246734 )
1990
19
Subdural empyema complicating frontal and ethmoid sinusitis. ( 2564381 )
1989
20
CT diagnosis of occult anterior ethmoid sinusitis in a case of lacrimal sac abscess. ( 3262299 )
1988
21
Fallibility of sinus radiographs in demonstrating ethmoid sinusitis. ( 3616799 )
1987
22
Brain abscess and ethmoid sinusitis presenting as periorbital cellulitis in a two-month-old infant. ( 3562144 )
1987
23
Radical surgical treatment for extensive chronic fronto-ethmoidal sinusitis. ( 3794540 )
1986
24
Orbital abscess secondary to ethmoidal sinusitis. ( 6605846 )
1983
25
Chronic ethmoid sinusitis due to foreign body. ( 7343837 )
1981
26
Complications of frontal and ethmoid sinusitis. ( 7359985 )
1980
27
Acute Frontal and Ethmoid Sinusitis with Subperiosteal Abscess. ( 29265274 )
1972
28
Acute frontal and ethmoid sinusitis with subperiosteal abscess. ( 5255101 )
1969
29
Ethmoid sinusitis in children. ( 13615441 )
1958
30
[Ethmoid sinusitis in infant]. ( 13217824 )
1954
31
Sphenoidal and Ethmoidal Sinusitis with Hemianopsia. ( 19989381 )
1933
32
Case of Labyrinthine Vertigo due to Sphenoidal and Ethmoidal Sinusitis. ( 19983931 )
1924

Variations for Ethmoid Sinusitis

Expression for Ethmoid Sinusitis

Search GEO for disease gene expression data for Ethmoid Sinusitis.

Pathways for Ethmoid Sinusitis

Pathways related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CRP CSF2 MUC1 MUC2 MUC4 MUC5AC
2
Show member pathways
13.43 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
3
Show member pathways
13.28 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
4
Show member pathways
12.21 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
5
Show member pathways
11.96 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
6
Show member pathways
11.94 CSF2 MUC5AC MUC5B
7
Show member pathways
11.83 MUC2 MUC5AC MUC5B
8
Show member pathways
11.66 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
9
Show member pathways
11.2 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6

GO Terms for Ethmoid Sinusitis

Cellular components related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 DCXR MUC1 MUC4 MUC5AC MUC5B MUC7
2 extracellular space GO:0005615 9.7 CRP CSF2 MUC1 MUC4 MUC5AC MUC5B
3 extracellular region GO:0005576 9.61 CRP CSF2 MUC1 MUC4 MUC5AC MUC5B
4 Golgi lumen GO:0005796 9.17 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6

Biological processes related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 CSF2 MUC1 PRTN3 TWIST1
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.5 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
3 maintenance of gastrointestinal epithelium GO:0030277 9.33 MUC2 MUC4 MUC6
4 O-glycan processing GO:0016266 9.17 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6

Sources for Ethmoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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