MCID: ETH009
MIFTS: 34

Ethmoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Ethmoid Sinusitis

MalaCards integrated aliases for Ethmoid Sinusitis:

Name: Ethmoid Sinusitis 12 44 15 73
Ethmoidal Sinusitis 12
Ethmoiditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9507
ICD10 33 J32.2
MeSH 44 D015521
NCIt 50 C34597
SNOMED-CT 68 18643000
UMLS 73 C0015029

Summaries for Ethmoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead.

MalaCards based summary : Ethmoid Sinusitis, also known as ethmoidal sinusitis, is related to paranasal sinus disease and subdural empyema. An important gene associated with Ethmoid Sinusitis is MUC7 (Mucin 7, Secreted), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. The drugs Hyaluronic acid and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, prostate and brain.

Related Diseases for Ethmoid Sinusitis

Diseases related to Ethmoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 paranasal sinus disease 32.1 MUC5B RHNO1
2 subdural empyema 30.5 CRP MUC5B
3 signet ring cell adenocarcinoma 30.0 MUC1 MUC2 MUC6
4 chronic ethmoiditis 29.7 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
5 acute ethmoiditis 12.1
6 olfactory neuroblastoma 11.1
7 acute inflammation of lacrimal passage 10.9 DCXR MUC7
8 dacryocystitis 10.9 DCXR MUC7
9 parasitic ichthyosporea infectious disease 10.8 DCXR RHNO1
10 frontal sinusitis 10.8 DCXR RHNO1
11 rhinosporidiosis 10.8 DCXR RHNO1
12 rhinoscleroma 10.8 DCXR RHNO1
13 acute orbital inflammation 10.7 CRP RHNO1
14 orbital cellulitis 10.7 CRP RHNO1
15 mastoiditis 10.7 CRP RHNO1
16 lung abscess 10.6 CRP MUC5B
17 cystic teratoma 10.6 MUC2 MUC6
18 diverticulitis 10.6 CRP DCXR
19 cryptogenic organizing pneumonia 10.5 MUC1 MUC5B
20 sinusitis 10.5
21 microcystic adenoma 10.5 MUC1 MUC6
22 sarcomatoid mesothelioma 10.5 MUC1 MUC4
23 appendix cancer 10.5 MUC1 MUC2
24 ampulla of vater adenocarcinoma 10.5 MUC1 MUC2
25 intracranial abscess 10.5 CRP TWIST1
26 mucinous cystadenocarcinoma 10.5 MUC1 MUC2
27 breast secretory carcinoma 10.4 MUC1 MUC4
28 neutrophilia, hereditary 10.3 CRP CSF2
29 gastrointestinal carcinoma 10.3 MUC1 MUC2
30 mixed ductal-endocrine carcinoma 10.3 MUC1 MUC6
31 tubular adenocarcinoma 10.3 MUC1 MUC2
32 orbital granuloma 10.3 MUC1 PRTN3
33 rapidly progressive glomerulonephritis 10.3 CRP PRTN3
34 mucinous adenocarcinoma 10.3 MUC1 MUC2
35 biliary tract neoplasm 10.2 MUC1 MUC2 MUC4
36 pancreatic intraductal papillary-mucinous neoplasm 10.2 MUC1 MUC2 MUC6
37 tumor of exocrine pancreas 10.2 MUC1 MUC2 MUC6
38 ampulla of vater neoplasm 10.2 MUC1 MUC2 MUC6
39 papillary adenocarcinoma 10.2 MUC1 MUC2
40 pharyngitis 10.2 CRP CSF2
41 bile duct carcinoma 10.2 MUC1 MUC2 MUC4
42 duodenum cancer 10.2 MUC1 MUC2 MUC6
43 adenomyoma 10.2 MUC1 MUC4 MUC6
44 chronic orbital inflammation 10.2 MUC1 PRTN3
45 endocardium disease 10.2 CRP PRTN3
46 pancreatic ductal carcinoma 10.2 MUC1 MUC2 MUC6
47 cholecystitis 10.2 MUC1 MUC2 MUC6
48 secretory meningioma 10.2 MUC1 MUC2
49 polyarteritis nodosa 10.2 CRP PRTN3
50 lipid pneumonia 10.2 CRP MUC1 MUC5B

Graphical network of the top 20 diseases related to Ethmoid Sinusitis:



Diseases related to Ethmoid Sinusitis

Symptoms & Phenotypes for Ethmoid Sinusitis

Drugs & Therapeutics for Ethmoid Sinusitis

Drugs for Ethmoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2 Anti-Bacterial Agents Not Applicable
3 Antibiotics, Antitubercular Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
2 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
3 Sinopsys® Lacrimal Stent Indicated for Sinus Irrigation Completed NCT03304951 Not Applicable
4 Sinopsys Lacrimal Stent Indicated for Sinus Irrigation Completed NCT02297243 Early Phase 1

Search NIH Clinical Center for Ethmoid Sinusitis

Cochrane evidence based reviews: ethmoid sinusitis

Genetic Tests for Ethmoid Sinusitis

Anatomical Context for Ethmoid Sinusitis

MalaCards organs/tissues related to Ethmoid Sinusitis:

41
Eye, Prostate, Brain

Publications for Ethmoid Sinusitis

Articles related to Ethmoid Sinusitis:

(show all 30)
# Title Authors Year
1
Safe treatment of ethmoid sinusitis utilizing minimally invasive ethmoid punch sinusotomy in chronic rhinosinusitis without polyposis patients. ( 28194802 )
2017
2
Neuroendocrine carcinoma of the ethmoid sinuses treated with radiotherapy alone. ( 22823986 )
2012
3
Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old. ( 24269390 )
2012
4
Cholesteatoma of the nose and maxillary and ethmoid sinuses: a rare complication of palatal surgery. ( 21938702 )
2011
5
Malakoplakia of the frontal and ethmoid sinuses mimicking a mucocele. ( 19358167 )
2009
6
Small cell neuroendocrine carcinoma of the ethmoid sinuses presenting with generalized seizure and syndrome of inappropriate antidiuretic hormone secretion: a case report and review of literature. ( 19027514 )
2009
7
Malignant ethmoid sinus tumor masquerading as chronic ethmoid sinusitis. ( 17240703 )
2006
8
Bacteriology of acute and chronic ethmoid sinusitis. ( 16000483 )
2005
9
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. ( 15472353 )
2004
10
Painful postganglionic Horners syndrome caused by ethmoid sinusitis. ( 15330830 )
2004
11
Microbiology of chronic ethmoid sinusitis: is this a bacterial disease? ( 15547805 )
2004
12
Peripheral scotoma associated with chronic ethmoidal sinusitis. A case report and review of the literature. ( 9695165 )
1998
13
Cerebral venous thrombosis associated with maxillary and ethmoid sinusitis--a case report. ( 8750066 )
1995
14
Bilateral ethmoid sinusitis with unilateral proptosis as an initial manifestation of metastatic prostate carcinoma. ( 7861473 )
1994
15
Radiological case of the month. Subperiosteal orbital abscess and ethmoid sinusitis. ( 1456261 )
1992
16
Clinical radiology quiz. Ethmoid sinusitis that lead to orbital and preseptal cellulitis. ( 1928603 )
1991
17
Evaluation of the microbiology of chronic ethmoid sinusitis. ( 1774242 )
1991
18
Subdural empyema complicating frontal and ethmoid sinusitis. ( 2564381 )
1989
19
Pathologic quiz case 2. Signet-ring cell adenocarcinoma of the ethmoid sinuses. ( 2551345 )
1989
20
CT diagnosis of occult anterior ethmoid sinusitis in a case of lacrimal sac abscess. ( 3262299 )
1988
21
Fallibility of sinus radiographs in demonstrating ethmoid sinusitis. ( 3616799 )
1987
22
Brain abscess and ethmoid sinusitis presenting as periorbital cellulitis in a two-month-old infant. ( 3562144 )
1987
23
Neurilemmoma of ethmoidal sinuses: a case report. ( 6520561 )
1984
24
Ossifying capillary hemangioma of the maxillary and ethmoid sinuses - a case report. ( 6801269 )
1981
25
Chronic ethmoid sinusitis due to foreign body. ( 7343837 )
1981
26
Complications of frontal and ethmoid sinusitis. ( 7359985 )
1980
27
Acute Frontal and Ethmoid Sinusitis with Subperiosteal Abscess. ( 29265274 )
1972
28
Acute frontal and ethmoid sinusitis with subperiosteal abscess. ( 5255101 )
1969
29
Ethmoid sinusitis in children. ( 13615441 )
1958
30
[Ethmoid sinusitis in infant]. ( 13217824 )
1954

Variations for Ethmoid Sinusitis

Expression for Ethmoid Sinusitis

Search GEO for disease gene expression data for Ethmoid Sinusitis.

Pathways for Ethmoid Sinusitis

Pathways related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CRP CSF2 MUC1 MUC2 MUC4 MUC5AC
2
Show member pathways
13.28 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
3
Show member pathways
12.21 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
4
Show member pathways
11.96 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
5
Show member pathways
11.94 CSF2 MUC5AC MUC5B
6
Show member pathways
11.83 MUC2 MUC5AC MUC5B
7
Show member pathways
11.66 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
8
Show member pathways
11.2 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6

GO Terms for Ethmoid Sinusitis

Cellular components related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 CRP DCXR MUC1 MUC4 MUC5AC MUC5B
2 extracellular space GO:0005615 9.7 CRP CSF2 MUC1 MUC4 MUC5AC MUC5B
3 extracellular region GO:0005576 9.61 CRP CSF2 MUC1 MUC4 MUC5AC MUC5B
4 Golgi lumen GO:0005796 9.17 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6

Biological processes related to Ethmoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 CSF2 MUC1 PRTN3 TWIST1
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.5 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6
3 maintenance of gastrointestinal epithelium GO:0030277 9.33 MUC2 MUC4 MUC6
4 O-glycan processing GO:0016266 9.17 MUC1 MUC2 MUC4 MUC5AC MUC5B MUC6

Sources for Ethmoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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