MCID: ETH012
MIFTS: 29

Ethylene Glycol Poisoning

Categories: Rare diseases

Aliases & Classifications for Ethylene Glycol Poisoning

Summaries for Ethylene Glycol Poisoning

MalaCards based summary : Ethylene Glycol Poisoning is related to metabolic acidosis and acute kidney failure. An important gene associated with Ethylene Glycol Poisoning is AKR1A1 (Aldo-Keto Reductase Family 1 Member A1). The drugs Fomepizole and Antidotes have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related phenotypes are lactic acidosis and metabolic acidosis

Wikipedia : 73 Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include... more...

Related Diseases for Ethylene Glycol Poisoning

Diseases related to Ethylene Glycol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 metabolic acidosis 11.0
2 acute kidney failure 10.7
3 ocular motor apraxia 10.6
4 lactic acidosis 10.5
5 meningoencephalitis 10.3
6 acute kidney tubular necrosis 10.3
7 alcohol use disorder 10.3
8 kidney disease 10.3
9 nephrolithiasis 10.3
10 ataxia and polyneuropathy, adult-onset 10.2
11 adult respiratory distress syndrome 10.2
12 nephrocalcinosis 10.2
13 inherited metabolic disorder 10.2
14 subacute delirium 10.2
15 seizure disorder 10.2
16 alcohol dependence 10.1
17 migraine with or without aura 1 10.1
18 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
19 methylmalonic aciduria due to methylmalonyl-coa mutase deficiency 10.1
20 kearns-sayre syndrome 10.1
21 propionic acidemia 10.1
22 dravet syndrome 10.1
23 myocardial infarction 10.1
24 hypophosphatemia 10.1
25 non-alcoholic fatty liver disease 10.1
26 combined immunodeficiency 10.1
27 interstitial nephritis 10.1
28 renal hypertension 10.1
29 dissociative disorder 10.1
30 respiratory failure 10.1
31 pyelonephritis 10.1
32 guillain-barre syndrome 10.1
33 facial paralysis 10.1
34 renal tubular acidosis 10.1
35 kidney cortex necrosis 10.1
36 primary hyperoxaluria 10.1
37 anuria 10.1
38 plague 10.1
39 gastritis 10.1
40 uremia 10.1
41 end stage renal disease 10.1
42 myocarditis 10.1
43 hypoglycemia 10.1
44 dysphagia 10.1
45 encephalopathy 10.1
46 hypotonia 10.1
47 posttransplant acute limbic encephalitis 10.1
48 methanol poisoning 10.1
49 cardiogenic shock 10.1

Graphical network of the top 20 diseases related to Ethylene Glycol Poisoning:



Diseases related to Ethylene Glycol Poisoning

Symptoms & Phenotypes for Ethylene Glycol Poisoning

Human phenotypes related to Ethylene Glycol Poisoning:

58 31 (show all 45)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lactic acidosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0003128
2 metabolic acidosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001942
3 ataxia 58 31 frequent (33%) Frequent (79-30%) HP:0001251
4 vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002013
5 slurred speech 58 31 frequent (33%) Frequent (79-30%) HP:0001350
6 hypocalcemia 58 31 frequent (33%) Frequent (79-30%) HP:0002901
7 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
8 tachypnea 58 31 frequent (33%) Frequent (79-30%) HP:0002789
9 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
10 drowsiness 58 31 frequent (33%) Frequent (79-30%) HP:0002329
11 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
12 euphoria 58 31 frequent (33%) Frequent (79-30%) HP:0031844
13 elevated serum anion gap 58 31 frequent (33%) Frequent (79-30%) HP:0031962
14 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
15 hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0000822
16 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
17 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
18 prolonged qt interval 58 31 occasional (7.5%) Occasional (29-5%) HP:0001657
19 headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0002315
20 hyperkalemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002153
21 atrial fibrillation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005110
22 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
23 cyanosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000961
24 gastritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0005263
25 pulmonary edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100598
26 abnormal pupillary light reflex 58 31 occasional (7.5%) Occasional (29-5%) HP:0007695
27 episodic respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0004885
28 shock 58 31 occasional (7.5%) Occasional (29-5%) HP:0031273
29 alcoholism 58 31 occasional (7.5%) Occasional (29-5%) HP:0030955
30 nystagmus 58 31 very rare (1%) Very rare (<4-1%) HP:0000639
31 hypothermia 58 31 very rare (1%) Very rare (<4-1%) HP:0002045
32 facial palsy 58 31 very rare (1%) Very rare (<4-1%) HP:0010628
33 renal tubular dysfunction 58 31 very rare (1%) Very rare (<4-1%) HP:0000124
34 myoclonus 58 31 very rare (1%) Very rare (<4-1%) HP:0001336
35 ophthalmoplegia 58 31 very rare (1%) Very rare (<4-1%) HP:0000602
36 hematuria 58 31 very rare (1%) Very rare (<4-1%) HP:0000790
37 encephalopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0001298
38 cerebral edema 58 31 very rare (1%) Very rare (<4-1%) HP:0002181
39 flank pain 58 31 very rare (1%) Very rare (<4-1%) HP:0030157
40 renal tubular epithelial necrosis 58 31 very rare (1%) Very rare (<4-1%) HP:0008682
41 decreased urine output 58 31 very rare (1%) Very rare (<4-1%) HP:0011037
42 seizure 31 very rare (1%) HP:0001250
43 seizures 58 Very rare (<4-1%)
44 abnormal pattern of respiration 58 Occasional (29-5%)
45 abnormal cranial nerve physiology 58 Very rare (<4-1%)

Drugs & Therapeutics for Ethylene Glycol Poisoning

Drugs for Ethylene Glycol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fomepizole Approved, Vet_approved 7554-65-6 3406
2 Antidotes
3 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Specified Drug-use Survey of Fomepizole Intravenous Infusion "Takeda" (All-case Surveillance) Recruiting NCT02415712 Fomepizole

Search NIH Clinical Center for Ethylene Glycol Poisoning

Genetic Tests for Ethylene Glycol Poisoning

Anatomical Context for Ethylene Glycol Poisoning

MalaCards organs/tissues related to Ethylene Glycol Poisoning:

40
Kidney, Heart, Endothelial, Whole Blood, Cortex, Liver

Publications for Ethylene Glycol Poisoning

Articles related to Ethylene Glycol Poisoning:

(show top 50) (show all 429)
# Title Authors PMID Year
1
Ethylene glycol poisoning: A diagnostic challenge in a patient with persistent seizures and a severe metabolic acidosis. 61
33425670 2021
2
[Diethylene glycol poisoning - the first known Swedish case]. 61
33616194 2021
3
Spurious point-of-care lactate elevation in ethylene glycol intoxication: rediscovering a clinical pearl. 61
33568412 2021
4
Challenges in Diagnosing Comatose Patients with Ethylene Glycol Poisoning. 61
32738197 2021
5
The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation. 61
33415501 2021
6
Loss of consciousness in a little traveler. 61
33680406 2021
7
Ethylene Glycol Poisoning with a Near-Normal Osmolal Gap: A Diagnostic Challenge. 61
33425517 2020
8
Calcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation. 61
32588315 2020
9
Unintentional Ethylene Glycol Poisoning in an Adolescent. 61
33354465 2020
10
A neonate with metabolic acidosis: A case report of intentional ethylene glycol poisoning. 61
33176951 2020
11
Zieve syndrome in acute alcoholic hepatitis. 61
32675955 2020
12
Stiripentol identifies a therapeutic target to reduce oxaluria. 61
32452916 2020
13
Educational Case: Ethylene Glycol Poisoning. 61
31984224 2020
14
Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico. 61
32186622 2019
15
Re: Stiripentol Protects against Calcium Oxalate Nephrolithiasis and Ethylene Glycol Poisoning. 61
31364941 2019
16
Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI. 61
31296606 2019
17
Ethylene glycol: Evidence of glucuronidation in vivo shown by analysis of clinical toxicology samples. 61
30845374 2019
18
Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. 61
30903181 2019
19
Erroneously High Lactate: A Guide to Diagnosing Ethylene Glycol Poisoning. 61
31993420 2019
20
Lactate dehydrogenase 5: identification of a druggable target to reduce oxaluria. 61
31107247 2019
21
Ethylene glycol poisoning: mind the gap. 61
31095547 2019
22
Stiripentol protects against calcium oxalate nephrolithiasis and ethylene glycol poisoning. 61
30946030 2019
23
[Antifreeze poisoning : The case of a patient with repeated ethylene glycol poisoning]. 61
29651677 2019
24
Treatment of Ethylene Glycol Poisoning with Oral Ethyl Alcohol. 61
30838047 2019
25
Therapeutic Applications of Ethanol: A Review. 61
31604058 2019
26
Time-dependent changes in kidney histopathology in ethylene glycol poisoning. 61
30124101 2018
27
Value of glycolic acid analysis in ethylene glycol poisoning: A clinical case report and systematic review of the literature. 61
30055870 2018
28
Rapid Diagnosis of Ethylene Glycol Poisoning by Urine Microscopy. 61
29899323 2018
29
Recurrent Ethylene Glycol Poisoning with Elevated Lactate Levels to Obtain Opioid Medications. 61
29627349 2018
30
A Rare Case of Severe Metabolic Alkalosis with Unusual Hyperproteinemia Treated with Continuous Renal Replacement Therapy and Regional Citrate Anticoagulation. 61
30197902 2018
31
Lactate gap as a tool in identifying ethylene glycol poisoning. 61
29525762 2018
32
Direct thermal desorption gas chromatographic determination of toxicologically relevant concentrations of ethylene glycol in whole blood. 61
29369312 2018
33
The Several Activities of 4 - Methyl Pyrazole in Animals and Humans. 61
29807511 2018
34
Lactate Gap: A Diagnostic Support in Severe Metabolic Acidosis of Unknown Origin. 61
30140287 2018
35
The importance of the histopathological examination in lethal acute intoxication with ethylene glycol. Case report. 61
30534841 2018
36
Effect of repeated administration of 4-methylpyrazole on renal function and lipid peroxidation products in rat kidney after ethylene glycol poisoning. 61
29091817 2017
37
A Case of Ethylene Glycol intoxication with Acute Renal Injury: Successful Recovery by Fomepizole and Renal Replacement Therapy. 61
29399024 2017
38
Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning? 61
29038192 2017
39
Ethylene Glycol Poisoning Should Not Contraindicate Liver Donation. 61
29026875 2017
40
Calcium oxalate monohydrate crystals in ethylene glycol poisoning. 61
27590893 2017
41
Simplifying the hemodialysis prescription in patients with ethylene glycol poisoning. 61
28709598 2017
42
Prediction and validation of the duration of hemodialysis sessions for the treatment of acute ethylene glycol poisoning. 61
28412021 2017
43
Assessment of a semi-quantitative screening method for diagnosis of ethylene glycol poisoning. 61
27687084 2017
44
Validation of a rapid, automated method for the measurement of ethylene glycol in human plasma. 61
27538769 2017
45
Serum Calcium Concentration in Ethylene Glycol Poisoning. 61
28083813 2017
46
Sequential episodes of ethylene glycol poisoning in the same person. 61
28551601 2017
47
Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis. 61
28150506 2017
48
Lactic acidosis: an update. 61
27522622 2017
49
Adolescent Presents With Altered Mental Status and Elevated Anion Gap After Suicide Attempt by Ethylene Glycol Ingestion. 61
26785093 2016
50
Ethylene glycol poisoning in three dogs: Importance of early diagnosis and role of hemodialysis as a treatment option. 61
27145686 2016

Variations for Ethylene Glycol Poisoning

Expression for Ethylene Glycol Poisoning

Search GEO for disease gene expression data for Ethylene Glycol Poisoning.

Pathways for Ethylene Glycol Poisoning

GO Terms for Ethylene Glycol Poisoning

Sources for Ethylene Glycol Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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