MCID: EMY001
MIFTS: 44

Eumycotic Mycetoma

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Eumycotic Mycetoma

MalaCards integrated aliases for Eumycotic Mycetoma:

Name: Eumycotic Mycetoma 12 15 17
Eumycetoma 12 77 74
Maduromycosis 12 74
Mycetoma 45 74
Maduromycosis, Mycotic 12
Mycotic Mycetoma 12
Mycetoma of Foot 74
Madura Foot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13078
MeSH 45 D008271
NCIt 51 C85505
ICD10 34 B47 B47.0 B47.9

Summaries for Eumycotic Mycetoma

Disease Ontology : 12 A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules.

MalaCards based summary : Eumycotic Mycetoma, also known as eumycetoma, is related to mycetoma and rhinosporidiosis. An important gene associated with Eumycotic Mycetoma is RPS3 (Ribosomal Protein S3), and among its related pathways/superpathways are NF-kappaB Signaling and Immune response IFN alpha/beta signaling pathway. The drugs Miconazole and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast, and related phenotypes are Decreased cell number and Decreased cell number

Wikipedia : 77 Eumycetoma is a chronic granulomatous fungal disease of humans, affecting mainly the limbs, and... more...

Related Diseases for Eumycotic Mycetoma

Diseases related to Eumycotic Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 mycetoma 31.2 CCL5 CHIT1 TPT1
2 rhinosporidiosis 29.8 CD68 UBC
3 dermatomycosis 10.4 CHIA RPS3
4 fusariosis 10.4 IFNG TEF
5 anal fistula 10.4 DEFB4A KIDINS220
6 cardiovascular syphilis 10.3 DDX41 SMUG1
7 shrimp allergy 10.3 ACTB IFNG
8 staphylococcal toxic shock syndrome 10.3 IFNG IL1B
9 trachea leiomyoma 10.3 SMUG1 TEF
10 african tick-bite fever 10.3 CCL5 IFNG
11 systemic lupus erythematosus 10.3
12 lupus erythematosus 10.3
13 anus disease 10.2 KIDINS220 SMUG1 TEF
14 von economo's disease 10.2 ACTB DDX41
15 folliculitis 10.2 CCL5 DEFB4A IFNG
16 chromoblastomycosis 10.2
17 posttransplant acute limbic encephalitis 10.2
18 filariasis 10.2 CCL5 CHIT1 IFNG
19 tonsillitis 10.2 DEFB4A IFNG IL1B
20 salmonellosis 10.2 DEFB4A IFNG IL1B
21 pulmonary artery leiomyosarcoma 10.2 CD68 SMUG1
22 bacterial infectious disease 10.2 DEFB4A IFNG IL1B
23 sternum cancer 10.2 CD68 SMUG1
24 brain sarcoma 10.2 CD68 SMUG1
25 aspergillosis 10.2
26 nocardiosis 10.2
27 temporal arteritis 10.2 CCL5 IFNG SMUG1
28 central nervous system vasculitis 10.2 IFNG IL1B SMUG1
29 primary bacterial infectious disease 10.1 DDX41 IFNG IL1B
30 intestinal disease 10.1 DEFB4A IL1B SMUG1
31 neuritis 10.1 CCL5 IFNG IL1B
32 actinomycosis 10.1
33 crustacean allergy 10.1 ACTB IFNG
34 autoimmune disease of central nervous system 10.1 CCL5 IFNG IL1B
35 upper respiratory tract disease 10.1 CCL5 IFNG IL1B
36 t-cell/histiocyte rich large b cell lymphoma 10.1 CD68 IFNG
37 trypanosomiasis 10.1 CCL5 IFNG IL1B
38 proteasome-associated autoinflammatory syndrome 1 10.1 CCL5 IFNG IL1B
39 relapsing-remitting multiple sclerosis 10.1 CCL5 IFNG TIMP1
40 hemangioma 10.1
41 fibroma 10.1
42 fibromatosis 10.1
43 ledderhose disease 10.1
44 septic arthritis 10.1
45 demyelinating disease 10.1 CCL5 IFNG IL1B
46 bone inflammation disease 10.1 IFNG IL1B TIMP1
47 pericoronitis 10.1 CD68 IL1B
48 periodontal disease 10.1 DEFB4A IL1B TIMP1
49 lactocele 10.1 CD68 SMUG1
50 sporotrichosis 10.1

Graphical network of the top 20 diseases related to Eumycotic Mycetoma:



Diseases related to Eumycotic Mycetoma

Symptoms & Phenotypes for Eumycotic Mycetoma

GenomeRNAi Phenotypes related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell number GR00098-A-1 9.17 CHIT1 RPS3 UBC
2 Decreased cell number GR00303-A 9.17 CHIT1 POLR2B RPS3 UBC

Drugs & Therapeutics for Eumycotic Mycetoma

Drugs for Eumycotic Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
3 Cytochrome P-450 Enzyme Inhibitors Phase 2
4
Hydroxyitraconazole Phase 2
5 Cytochrome P-450 CYP3A Inhibitors Phase 2
6 Hormones Phase 2
7 Anti-Infective Agents Phase 2
8 Steroid Synthesis Inhibitors Phase 2
9 Hormone Antagonists Phase 2
10 Antifungal Agents Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Eumycotic Mycetoma

Cochrane evidence based reviews: mycetoma

Genetic Tests for Eumycotic Mycetoma

Anatomical Context for Eumycotic Mycetoma

MalaCards organs/tissues related to Eumycotic Mycetoma:

42
Skin, Testes, Breast, Liver, Bone, Heart

Publications for Eumycotic Mycetoma

Articles related to Eumycotic Mycetoma:

(show top 50) (show all 102)
# Title Authors Year
1
Surgical management of eumycetoma: experience from Gezira Mycetoma Center, Sudan. ( 30675125 )
2019
2
Plantar Eumycetoma by Madurella mycetomatis in a heart-transplanted patient living in Portugal. ( 29150882 )
2018
3
Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America. ( 29263207 )
2018
4
Ultrasound Assessment of a Subcutaneous Eumycetoma of the Eyebrow in an Immunocompromised Patient. ( 29338839 )
2018
5
Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. ( 29698504 )
2018
6
Isolated Primary Corneal Acremonium Eumycetoma: Case Report and Literature Review. ( 30234681 )
2018
7
Eumycetoma pedis in an Albanian farmer. ( 30566558 )
2018
8
Broncho-pleuro-cutaneous fistula and pneumothorax: Rare challenging complications of chest wall eumycetoma. ( 28957324 )
2017
9
Aspergillus: An uncommon pathogen of eumycetoma. ( 27612290 )
2017
10
PET/CT and MRI Imaging of a Eumycetoma of the Right Thigh. ( 27775941 )
2017
11
Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature. ( 27928841 )
2017
12
Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country. ( 28406907 )
2017
13
Eumycetoma caused by Trichophyton species successfully treated with terbinafine and surgery. ( 28447356 )
2017
14
Detection of (1→3)-β-d-Glucan in Eumycetoma Patients. ( 27440815 )
2016
15
Black grain eumycetoma of the breast-misdiagnosed, incidental or iatrogenic? ( 26924406 )
2016
16
Phaeoacremonium sphinctrophorum as a Novel Agent of Eumycetoma. ( 27224667 )
2016
17
A non-steroidal anti-inflammatory drug to treat eumycetoma. ( 27352758 )
2016
18
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. ( 27434108 )
2016
19
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2015
20
Eumycetoma Osteomyelitis of the Calcaneus in a Child: A Radiologic-Pathologic Correlation following Total Calcanectomy. ( 26483983 )
2015
21
Eumycetoma on the foot caused by Madurella mycetomatis: amputation after significant worsening during pregnancy. ( 25178425 )
2015
22
First reported case of Aspergillus nidulans eumycetoma in a sporotrichoid distribution. ( 25267555 )
2015
23
In vitro activity of antiseptic solutions against Madurella mycetomatis: implications for eumycetoma management. ( 25429729 )
2015
24
Treatment for a eumycetoma infection caused by Aspergillus in an immunocompromised host: a case report. ( 25537527 )
2015
25
In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals. ( 25631481 )
2015
26
Eumycetoma and actinomycetoma--an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. ( 25726758 )
2015
27
Atypical craniocerebral eumycetoma: A case report and review of literature. ( 25767591 )
2015
28
The in vitro antifungal activity of sudanese medicinal plants against Madurella mycetomatis, the eumycetoma major causative agent. ( 25768115 )
2015
29
Efficient staining of actinomycetoma and eumycetoma grains using henna extract. ( 26052737 )
2015
30
Black grain eumycetoma of the breast misdiagnosed as fibroadenoma. ( 26261141 )
2015
31
Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry. ( 26497138 )
2015
32
Case report: Eumycetoma and mycotic arthritis of the knee caused by Arthrographis kalrae. ( 26719609 )
2015
33
Oral eumycetoma of infancy: a rare presentation and a brief review. ( 23522832 )
2014
34
Curvularia lunata: a rare cause of black-grain eumycetoma. ( 24139180 )
2014
35
The combination of amoxicillin-clavulanic acid and ketoconazole in the treatment of Madurella mycetomatis eumycetoma and Staphylococcus aureus co-infection. ( 24945499 )
2014
36
Last generation triazoles for imported eumycetoma in eleven consecutive adults. ( 25299610 )
2014
37
Rapid identification of black grain eumycetoma causative agents using rolling circle amplification. ( 25474355 )
2014
38
Revision of agents of black-grain eumycetoma in the order Pleosporales. ( 25737597 )
2014
39
Canine eumycetoma caused by Cladophialophora bantiana in a Maltese: case report and literature review. ( 23294374 )
2013
40
An unusual case of eumycetoma caused by Exophiala jeanselmei after a sea urchin injury. ( 23406480 )
2013
41
Oral cavity eumycetoma: a rare and unusual condition. ( 23522651 )
2013
42
Erratum to "A Rare Presentation of Concurrent Scedosporium apiospermum and Madurella grisea Eumycetoma in an Immunocompetent Host". ( 23533896 )
2013
43
Eumycetoma of the foot caused by Exophiala jeanselmei in a Guinean woman. ( 23871385 )
2013
44
Eumycetoma by Madurella mycetomatis with 30 years of evolution: therapeutic challenge. ( 24346887 )
2013
45
Fusarium subglutinans: A new eumycetoma agent. ( 24432236 )
2013
46
Eumycetoma due to Acremonium falciforme acquired in China. ( 21749480 )
2012
47
Eumycetoma. ( 22682186 )
2012
48
Pleurostomophora ochracea, a novel agent of human eumycetoma with yellow grains. ( 22760037 )
2012
49
Pustules and sinus tracts involving the right arm of an elderly patient--quiz case. Diagnosis: eumycetoma. ( 23069959 )
2012
50
A Rare Presentation of Concurrent Scedosporium apiospermum and Madurella grisea Eumycetoma in an Immunocompetent Host. ( 23133772 )
2012

Variations for Eumycotic Mycetoma

Expression for Eumycotic Mycetoma

Search GEO for disease gene expression data for Eumycotic Mycetoma.

Pathways for Eumycotic Mycetoma

GO Terms for Eumycotic Mycetoma

Cellular components related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 ACTB CCL5 CHIA CHIT1 DEFB4A IFNG

Biological processes related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.73 CCL5 IL1B TIMP1 UBC
2 response to virus GO:0009615 9.65 CCL5 IFNG TPT1
3 regulation of insulin secretion GO:0050796 9.58 CCL5 IFNG IL1B
4 immune response GO:0006955 9.55 CCL5 CHIT1 DEFB4A IFNG IL1B
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG IL1B
6 polysaccharide digestion GO:0044245 9.37 CHIA CHIT1
7 chitin catabolic process GO:0006032 9.32 CHIA CHIT1
8 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IFNG IL1B
9 chitin metabolic process GO:0006030 8.96 CHIA CHIT1
10 polysaccharide catabolic process GO:0000272 8.62 CHIA CHIT1

Molecular functions related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA N-glycosylase activity GO:0019104 9.26 RPS3 SMUG1
2 cytokine activity GO:0005125 9.26 CCL5 IFNG IL1B TIMP1
3 chitin binding GO:0008061 9.16 CHIA CHIT1
4 chitinase activity GO:0004568 8.62 CHIA CHIT1

Sources for Eumycotic Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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