MCID: EMY001
MIFTS: 44

Eumycotic Mycetoma

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Eumycotic Mycetoma

MalaCards integrated aliases for Eumycotic Mycetoma:

Name: Eumycotic Mycetoma 12 15
Eumycetoma 12 76 73
Maduromycosis 12 73
Mycetoma 44 73
Maduromycosis, Mycotic 12
Mycotic Mycetoma 12
Mycetoma of Foot 73
Madura Foot 12

Classifications:



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Disease Ontology 12 DOID:13078
ICD10 33 B47 B47.9 B47.0
MeSH 44 D008271
NCIt 50 C85505

Summaries for Eumycotic Mycetoma

Disease Ontology : 12 A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules.

MalaCards based summary : Eumycotic Mycetoma, also known as eumycetoma, is related to mycetoma and rhinosporidiosis. An important gene associated with Eumycotic Mycetoma is RPS3 (Ribosomal Protein S3), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Itraconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone.

Wikipedia : 76 Eumycetoma is a chronic granulomatous fungal disease of humans, affecting mainly the limbs, and... more...

Related Diseases for Eumycotic Mycetoma

Diseases related to Eumycotic Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 mycetoma 31.2 CCL5 CR1 TPT1
2 rhinosporidiosis 29.7 CD68 UBC
3 dermatomycosis 10.3 CHIA RPS3
4 fusariosis 10.3 IFNG TEF
5 parapharyngeal meningioma 10.2 CR1 SMUG1
6 systemic lupus erythematosus 10.2
7 lupus erythematosus 10.2
8 cardiovascular syphilis 10.2 DDX41 SMUG1
9 shrimp allergy 10.2 ACTB IFNG
10 chromoblastomycosis 10.2
11 posttransplant acute limbic encephalitis 10.2
12 staphylococcal toxic shock syndrome 10.2 IFNG IL1B
13 african tick-bite fever 10.2 CCL5 IFNG
14 trachea leiomyoma 10.2 SMUG1 TEF
15 von economo's disease 10.1 ACTB DDX41
16 aspergillosis 10.1
17 folliculitis 10.1 CCL5 DEFB4A IFNG
18 rheumatoid lung disease 10.1 IL1B SMUG1
19 tonsillitis 10.1 DEFB4A IFNG IL1B
20 salmonellosis 10.1 DEFB4A IFNG IL1B
21 pulmonary artery leiomyosarcoma 10.1 CD68 SMUG1
22 bacterial infectious disease 10.1 DEFB4A IFNG IL1B
23 sternum cancer 10.1 CD68 SMUG1
24 temporal arteritis 10.1 CCL5 IFNG SMUG1
25 brain sarcoma 10.1 CD68 SMUG1
26 actinomycosis 10.1
27 central nervous system vasculitis 10.1 IFNG IL1B SMUG1
28 nocardiosis 10.1
29 primary bacterial infectious disease 10.1 DDX41 IFNG IL1B
30 immune system disease 10.1 DDX41 IFNG IL1B
31 intestinal disease 10.1 DEFB4A IL1B SMUG1
32 neuritis 10.1 CCL5 IFNG IL1B
33 crustacean allergy 10.1 ACTB IFNG
34 hemangioma 10.1
35 fibromatosis 10.1
36 ledderhose disease 10.1
37 autoimmune disease of central nervous system 10.1 CCL5 IFNG IL1B
38 upper respiratory tract disease 10.1 CCL5 IFNG IL1B
39 t-cell/histiocyte rich large b cell lymphoma 10.1 CD68 CR1 IFNG
40 trypanosomiasis 10.1 CCL5 IFNG IL1B
41 dendritic cell tumor 10.1 CD68 CR1 IFNG
42 proteasome-associated autoinflammatory syndrome 1 10.1 CCL5 IFNG IL1B
43 relapsing-remitting multiple sclerosis 10.1 CCL5 IFNG TIMP1
44 demyelinating disease 10.1 CCL5 IFNG IL1B
45 bone inflammation disease 10.1 IFNG IL1B TIMP1
46 periodontitis 10.0 IFNG IL1B TIMP1
47 pericoronitis 10.0 CD68 IL1B
48 sporotrichosis 10.0
49 periodontal disease 10.0 DEFB4A IL1B TIMP1
50 cardiac sarcoidosis 10.0 IFNG SMUG1

Graphical network of the top 20 diseases related to Eumycotic Mycetoma:



Diseases related to Eumycotic Mycetoma

Symptoms & Phenotypes for Eumycotic Mycetoma

Drugs & Therapeutics for Eumycotic Mycetoma

Drugs for Eumycotic Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3 Cytochrome P-450 CYP3A Inhibitors Phase 2
4 Hormones Phase 2
5 Cytochrome P-450 Enzyme Inhibitors Phase 2
6 Steroid Synthesis Inhibitors Phase 2
7
Hydroxyitraconazole Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
9 Hormone Antagonists Phase 2
10 Antifungal Agents Phase 2
11 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Eumycotic Mycetoma

Cochrane evidence based reviews: mycetoma

Genetic Tests for Eumycotic Mycetoma

Anatomical Context for Eumycotic Mycetoma

MalaCards organs/tissues related to Eumycotic Mycetoma:

41
Skin, Testes, Bone, Lung, Brain, Kidney, Prostate

Publications for Eumycotic Mycetoma

Articles related to Eumycotic Mycetoma:

(show top 50) (show all 100)
# Title Authors Year
1
Plantar Eumycetoma by Madurella mycetomatis in a heart-transplanted patient living in Portugal. ( 29150882 )
2018
2
Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America. ( 29263207 )
2018
3
Ultrasound Assessment of a Subcutaneous Eumycetoma of the Eyebrow in an Immunocompromised Patient. ( 29338839 )
2018
4
Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. ( 29698504 )
2018
5
Isolated Primary Corneal Acremonium Eumycetoma: Case Report and Literature Review. ( 30234681 )
2018
6
Broncho-pleuro-cutaneous fistula and pneumothorax: Rare challenging complications of chest wall eumycetoma. ( 28957324 )
2017
7
Aspergillus: An uncommon pathogen of eumycetoma. ( 27612290 )
2017
8
PET/CT and MRI Imaging of a Eumycetoma of the Right Thigh. ( 27775941 )
2017
9
Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature. ( 27928841 )
2017
10
Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country. ( 28406907 )
2017
11
Eumycetoma caused by Trichophyton species successfully treated with terbinafine and surgery. ( 28447356 )
2017
12
Black grain eumycetoma of the breast-misdiagnosed, incidental or iatrogenic? ( 26924406 )
2016
13
Phaeoacremonium sphinctrophorum as a Novel Agent of Eumycetoma. ( 27224667 )
2016
14
A non-steroidal anti-inflammatory drug to treat eumycetoma. ( 27352758 )
2016
15
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. ( 27434108 )
2016
16
Detection of (1→3)-β-d-Glucan in Eumycetoma Patients. ( 27440815 )
2016
17
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2015
18
Eumycetoma on the foot caused by Madurella mycetomatis: amputation after significant worsening during pregnancy. ( 25178425 )
2015
19
First reported case of Aspergillus nidulans eumycetoma in a sporotrichoid distribution. ( 25267555 )
2015
20
In vitro activity of antiseptic solutions against Madurella mycetomatis: implications for eumycetoma management. ( 25429729 )
2015
21
Treatment for a eumycetoma infection caused by Aspergillus in an immunocompromised host: a case report. ( 25537527 )
2015
22
In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals. ( 25631481 )
2015
23
Eumycetoma and actinomycetoma--an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. ( 25726758 )
2015
24
Atypical craniocerebral eumycetoma: A case report and review of literature. ( 25767591 )
2015
25
The in vitro antifungal activity of sudanese medicinal plants against Madurella mycetomatis, the eumycetoma major causative agent. ( 25768115 )
2015
26
Efficient staining of actinomycetoma and eumycetoma grains using henna extract. ( 26052737 )
2015
27
Black grain eumycetoma of the breast misdiagnosed as fibroadenoma. ( 26261141 )
2015
28
Eumycetoma Osteomyelitis of the Calcaneus in a Child: A Radiologic-Pathologic Correlation following Total Calcanectomy. ( 26483983 )
2015
29
Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry. ( 26497138 )
2015
30
Case report: Eumycetoma and mycotic arthritis of the knee caused by Arthrographis kalrae. ( 26719609 )
2015
31
Oral eumycetoma of infancy: a rare presentation and a brief review. ( 23522832 )
2014
32
Curvularia lunata: a rare cause of black-grain eumycetoma. ( 24139180 )
2014
33
The combination of amoxicillin-clavulanic acid and ketoconazole in the treatment of Madurella mycetomatis eumycetoma and Staphylococcus aureus co-infection. ( 24945499 )
2014
34
Last generation triazoles for imported eumycetoma in eleven consecutive adults. ( 25299610 )
2014
35
Rapid identification of black grain eumycetoma causative agents using rolling circle amplification. ( 25474355 )
2014
36
Revision of agents of black-grain eumycetoma in the order Pleosporales. ( 25737597 )
2014
37
Canine eumycetoma caused by Cladophialophora bantiana in a Maltese: case report and literature review. ( 23294374 )
2013
38
An unusual case of eumycetoma caused by Exophiala jeanselmei after a sea urchin injury. ( 23406480 )
2013
39
Oral cavity eumycetoma: a rare and unusual condition. ( 23522651 )
2013
40
Erratum to "A Rare Presentation of Concurrent Scedosporium apiospermum and Madurella grisea Eumycetoma in an Immunocompetent Host". ( 23533896 )
2013
41
Eumycetoma of the foot caused by Exophiala jeanselmei in a Guinean woman. ( 23871385 )
2013
42
Eumycetoma by Madurella mycetomatis with 30 years of evolution: therapeutic challenge. ( 24346887 )
2013
43
Fusarium subglutinans: A new eumycetoma agent. ( 24432236 )
2013
44
Eumycetoma due to Acremonium falciforme acquired in China. ( 21749480 )
2012
45
Eumycetoma. ( 22682186 )
2012
46
Pleurostomophora ochracea, a novel agent of human eumycetoma with yellow grains. ( 22760037 )
2012
47
Pustules and sinus tracts involving the right arm of an elderly patient--quiz case. Diagnosis: eumycetoma. ( 23069959 )
2012
48
A Rare Presentation of Concurrent Scedosporium apiospermum and Madurella grisea Eumycetoma in an Immunocompetent Host. ( 23133772 )
2012
49
The safety and efficacy of itraconazole for the treatment of patients with eumycetoma due to Madurella mycetomatis. ( 21247608 )
2011
50
Eumycetoma of the hand caused by Leptosphaeria tompkinsii and refractory to medical therapy with voriconazole. ( 21567225 )
2011

Variations for Eumycotic Mycetoma

Expression for Eumycotic Mycetoma

Search GEO for disease gene expression data for Eumycotic Mycetoma.

Pathways for Eumycotic Mycetoma

GO Terms for Eumycotic Mycetoma

Cellular components related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 ACTB CCL5 CHIA DEFB4A IFNG IL1B

Biological processes related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.83 CHIA DDX41 IFNG IL1B RPS3
2 response to virus GO:0009615 9.58 CCL5 IFNG TPT1
3 cytokine-mediated signaling pathway GO:0019221 9.56 CCL5 IL1B TIMP1 UBC
4 immune response GO:0006955 9.55 CCL5 CHIA DEFB4A IFNG IL1B
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.37 IFNG IL1B
6 regulation of regulatory T cell differentiation GO:0045589 9.32 CR1 IFNG
7 regulation of insulin secretion GO:0050796 9.13 CCL5 IFNG IL1B
8 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Molecular functions related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA N-glycosylase activity GO:0019104 8.96 RPS3 SMUG1
2 cytokine activity GO:0005125 8.92 CCL5 IFNG IL1B TIMP1
3 protein binding GO:0005515 10.03 ACTB CCL5 CHIA DDX41 DEFB4A IFNG

Sources for Eumycotic Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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