MCID: EMY001
MIFTS: 34

Eumycotic Mycetoma

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Eumycotic Mycetoma

MalaCards integrated aliases for Eumycotic Mycetoma:

Name: Eumycotic Mycetoma 12 15 17
Eumycetoma 12 74 71 32
Maduromycosis 12 71
Mycetoma 43 71
Maduromycosis, Mycotic 12
Mycotic Mycetoma 12
Mycetoma of Foot 71
Madura Foot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13078
MeSH 43 D008271
NCIt 49 C85505
ICD10 32 B47 B47.0 B47.9
UMLS 71 C0024449 C2350619 C2350621 more

Summaries for Eumycotic Mycetoma

Disease Ontology : 12 A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules.

MalaCards based summary : Eumycotic Mycetoma, also known as eumycetoma, is related to mycetoma and subcutaneous mycosis. An important gene associated with Eumycotic Mycetoma is POLR2B (RNA Polymerase II Subunit B). The drugs Guaifenesin and Antitussive Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotype is Decreased cell number.

Wikipedia : 74 Eumycetoma is a chronic granulomatous fungal disease of humans, affecting mainly the limbs, and... more...

Related Diseases for Eumycotic Mycetoma

Diseases related to Eumycotic Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 mycetoma 31.5 TPT1 CHIT1
2 subcutaneous mycosis 30.4 POLR2B CBSL
3 dermatophytosis 30.0 POLR2B CBSL
4 phaeohyphomycosis 29.8 TUB POLR2B CBSL
5 aspergillosis 10.5
6 osteomyelitis 10.4
7 nocardiosis 10.3
8 systemic lupus erythematosus 10.3
9 disseminated intravascular coagulation 10.3
10 diarrhea 10.3
11 peritonitis 10.3
12 actinomycosis 10.3
13 lupus erythematosus 10.3
14 hypoglycemia 10.3
15 lung disease 10.3
16 bacterial infectious disease 10.3
17 chromoblastomycosis 10.3
18 posttransplant acute limbic encephalitis 10.3
19 candidiasis 10.3
20 pulmonary tuberculosis 10.3
21 endocarditis 10.2
22 sporotrichosis 10.2
23 sarcoidosis 1 10.2
24 otomycosis 10.2 POLR2B CBSL
25 leprosy 3 10.1
26 coccidioidomycosis 10.1
27 hansen's disease 10.1
28 filariasis 10.1
29 strongyloidiasis 10.1
30 allergic hypersensitivity disease 10.1
31 enterobiasis 10.1
32 septic arthritis 10.1
33 parasitic helminthiasis infectious disease 10.1
34 amyloidosis 10.1
35 amebiasis 10.1
36 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
37 buruli ulcer 10.1
38 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
39 fibroma 10.1
40 gout 10.1
41 hemangioma 10.1
42 bone inflammation disease 10.1
43 fibromatosis 10.1
44 ledderhose disease 10.1
45 spondyloarthropathy 1 10.1
46 mycobacterium tuberculosis 1 10.1
47 invasive aspergillosis 10.1
48 inflammatory spondylopathy 10.1
49 pulmonary sarcoidosis 10.1
50 tinea capitis 10.1

Graphical network of the top 20 diseases related to Eumycotic Mycetoma:



Diseases related to Eumycotic Mycetoma

Symptoms & Phenotypes for Eumycotic Mycetoma

GenomeRNAi Phenotypes related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell number GR00303-A 8.8 CHIT1 POLR2B RPS3

Drugs & Therapeutics for Eumycotic Mycetoma

Drugs for Eumycotic Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2 Antitussive Agents Phase 4
3 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
4
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6 Anti-Infective Agents Phase 3
7 Cytochrome P-450 CYP3A Inhibitors Phase 3
8 Cytochrome P-450 Enzyme Inhibitors Phase 3
9
Hydroxyitraconazole Phase 3
10 Hormone Antagonists Phase 3
11 Antifungal Agents Phase 3
12 Steroid Synthesis Inhibitors Phase 3
13 Hormones Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A RANDOMIZED CONTROLLED STUDY OF ITRACONAZOLE IN CHRONIC CAVITARY PULMONARY ASPERGILLOSIS Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
2 A Randomized Controlled Trial to Compare the Clinical Outcomes of Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis Recruiting NCT03920527 Phase 3 Itraconazole 400 mg
3 A Randomized, Double Blind Phase II Proof-of-Concept Superiority Trial of Fosravuconazole 200 mg or 300 mg Weekly Dose Versus Itraconazole 400 mg Daily, All Three Arms in Combination With Surgery, in Patients With Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole
4 The Utility of External Beam Radiotherapy for Haemoptysis Secondary to Aspergillomata and Structural Lung Diseases in Patients Who Are Refractory to Medical Management and Not Surgical Candidates: A Pilot Study Unknown status NCT02878447
5 Prevalence Survey for Innovative and Intensified Disease Management (IDM) Neglected Tropical Diseases (NTDs): A Cluster Randomised Two-stage Active Case Search for IDM-NTDs in Liberia Recruiting NCT03683745

Search NIH Clinical Center for Eumycotic Mycetoma

Cochrane evidence based reviews: mycetoma

Genetic Tests for Eumycotic Mycetoma

Anatomical Context for Eumycotic Mycetoma

MalaCards organs/tissues related to Eumycotic Mycetoma:

40
Skin, Testes, Lung, Kidney, Breast, Bone, Heart

Publications for Eumycotic Mycetoma

Articles related to Eumycotic Mycetoma:

(show top 50) (show all 295)
# Title Authors PMID Year
1
Actinomycetoma Caused by Actinomadura mexicana, A Neglected Entity in the Caribbean. 61
31961313 2020
2
Madurella mycetomatis infection of the foot: a case report of a neglected tropical disease in a non-endemic region. 61
31918687 2020
3
The potential role of interleukin-37 in infectious diseases. 61
31633447 2020
4
Madurella real-time PCR, a novel approach for eumycetoma diagnosis. 61
31940343 2020
5
Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim. 61
31904836 2020
6
Recurrent eumycetoma caused by novel species Madurella pseudomycetomatis: A case report. 61
31667052 2019
7
Eumycetoma diagnosed in urban Australia. 61
31872879 2019
8
Epidemiological profile of eumycetomas in Rabat, Morocco, over 40 years. 61
31587988 2019
9
Epidemiological profile and spectrum of neglected tropical disease eumycetoma from Delhi, North India. 61
31637988 2019
10
Dermoscopy of Eumycotic Mycetoma: A Case Report. 61
31723465 2019
11
[Eumycetoma due to Fusarium chlamydosporum : Case report und review of the literature]. 61
31289888 2019
12
The Accuracy of Histopathological and Cytopathological Techniques in the Identification of the Mycetoma Causative Agents. 61
31465459 2019
13
VNTR confirms the heterogeneity of Madurella mycetomatis and is a promising typing tool for this mycetoma causing agent. 61
30085253 2019
14
Diagnosis and Management of Fungal Neglected Tropical Diseases In Community Settings-Mycetoma and Sporotrichosis. 61
31100844 2019
15
Surgical Management of Mycetoma in Chad: Experience from the French Forward Surgical Team Deployed in N'Djamena. 61
31379342 2019
16
Mycetoma: A Common Yet Unrecognized Health Burden in Central India. 61
31149567 2019
17
Chaetomium atrobrunneum causing human eumycetoma: The first report. 61
31145740 2019
18
The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis. 61
30946748 2019
19
Mycetoma in China: A Case Report and Review of the Literature. 61
30887177 2019
20
Mycetoma: reviewing a neglected disease. 61
29808607 2019
21
Madurella mycetomatis infection of the buttock in an Eritrean refugee in Switzerland: a case report. 61
30755254 2019
22
Surgical management of eumycetoma: experience from Gezira Mycetoma Center, Sudan. 61
30675125 2019
23
Isolated Primary Corneal Acremonium Eumycetoma: Case Report and Literature Review. 61
30234681 2018
24
Mycetoma in the Togolese: An Update from a Single-Center Experience. 61
29557534 2018
25
Opportunistic Fungal Infections in Small Animals. 61
30272479 2018
26
Eumycetoma pedis in an Albanian farmer. 61
30566558 2018
27
Ultrasound Assessment of a Subcutaneous Eumycetoma of the Eyebrow in an Immunocompromised Patient. 61
29338839 2018
28
Therapy of Non-Dermatophytic Mycoses in Animals. 61
30380772 2018
29
Mycetoma: a clinical dilemma in resource limited settings. 61
30097030 2018
30
Pedal Fungal Mass in the Midwest. 61
30156886 2018
31
Treatment of Madura foot: a systematic review. 61
29995713 2018
32
Giant cell tumour of tendon sheath: A 10-year study from a tertiary care centre. 61
29575183 2018
33
Plantar Eumycetoma by Madurella mycetomatis in a heart-transplanted patient living in Portugal. 61
29150882 2018
34
Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. 61
29698504 2018
35
Closing the mycetoma knowledge gap. 61
28992217 2018
36
Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America. 61
29263207 2018
37
Mycetomas: an epidemiological, etiological, clinical, laboratory and therapeutic review. 61
29641691 2018
38
Epitope-Based Peptide Vaccine Against Fructose-Bisphosphate Aldolase of Madurella mycetomatis Using Immunoinformatics Approaches. 61
30542244 2018
39
Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16-year-old Fjord pony gelding with pituitary pars intermedia dysfunction. 61
28736852 2017
40
Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease. 61
28670680 2017
41
Broncho-pleuro-cutaneous fistula and pneumothorax: Rare challenging complications of chest wall eumycetoma. 61
28957324 2017
42
Rapid and Robust Identification of the Agents of Black-Grain Mycetoma by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. 61
28592546 2017
43
Mycetoma: An Update. 61
28794542 2017
44
Combining two antifungal agents does not enhance survival of Galleria mellonella larvae infected with Madurella mycetomatis. 61
28342219 2017
45
Eumycetoma caused by Trichophyton species successfully treated with terbinafine and surgery. 61
28447356 2017
46
Eyelid Mycetoma Masquerading as Sebaceous Carcinoma. 61
26882058 2017
47
Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country. 61
28406907 2017
48
Dot-in-Circle Sign - A Diagnostic MRI Sign for "Madura Foot". 61
28302229 2017
49
Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature. 61
27928841 2017
50
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. 61
28192433 2017

Variations for Eumycotic Mycetoma

Expression for Eumycotic Mycetoma

Search GEO for disease gene expression data for Eumycotic Mycetoma.

Pathways for Eumycotic Mycetoma

GO Terms for Eumycotic Mycetoma

Cellular components related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.28 UBASH3A TUB TPT1 RPS3 LIX1 IL37

Sources for Eumycotic Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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