MCID: EMY001
MIFTS: 44

Eumycotic Mycetoma

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Eumycotic Mycetoma

MalaCards integrated aliases for Eumycotic Mycetoma:

Name: Eumycotic Mycetoma 12 15 17
Eumycetoma 12 77 74
Maduromycosis 12 74
Mycetoma 45 74
Maduromycosis, Mycotic 12
Mycotic Mycetoma 12
Mycetoma of Foot 74
Madura Foot 12

Classifications:



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Disease Ontology 12 DOID:13078
MeSH 45 D008271
NCIt 51 C85505
ICD10 34 B47 B47.0 B47.9

Summaries for Eumycotic Mycetoma

Disease Ontology : 12 A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules.

MalaCards based summary : Eumycotic Mycetoma, also known as eumycetoma, is related to mycetoma and multiple sclerosis. An important gene associated with Eumycotic Mycetoma is RPS3 (Ribosomal Protein S3), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Miconazole and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung.

Wikipedia : 77 Eumycetoma is a chronic granulomatous fungal disease of humans, affecting mainly the limbs, and... more...

Related Diseases for Eumycotic Mycetoma

Diseases related to Eumycotic Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 mycetoma 31.2 CCL5 CHIT1 TPT1
2 multiple sclerosis 29.7 CCL5 CHIT1 IFNG IL1B
3 dermatomycosis 10.4 CHIA RPS3
4 anal fistula 10.4 DEFB4A KIDINS220
5 fusariosis 10.4 IFNG TEF
6 staphylococcal toxic shock syndrome 10.3 IFNG IL1B
7 systemic lupus erythematosus 10.3
8 lupus erythematosus 10.3
9 shrimp allergy 10.3 ACTB IFNG
10 tonsillitis 10.2 DEFB4A IFNG IL1B
11 chromoblastomycosis 10.2
12 posttransplant acute limbic encephalitis 10.2
13 salmonellosis 10.2 DEFB4A IFNG IL1B
14 african tick-bite fever 10.2 CCL5 IFNG
15 bacterial infectious disease 10.2 DEFB4A IFNG IL1B
16 von economo's disease 10.2 ACTB DDX41
17 folliculitis 10.2 CCL5 DEFB4A IFNG
18 filariasis 10.2 CCL5 CHIT1 IFNG
19 aspergillosis 10.2
20 nocardiosis 10.2
21 crustacean allergy 10.2 ACTB IFNG
22 campylobacteriosis 10.2 IFNG IL1B
23 primary bacterial infectious disease 10.1 DDX41 IFNG IL1B
24 neuritis 10.1 CCL5 IFNG IL1B
25 actinomycosis 10.1
26 autoimmune disease of central nervous system 10.1 CCL5 IFNG IL1B
27 upper respiratory tract disease 10.1 CCL5 IFNG IL1B
28 pericoronitis 10.1 CD68 IL1B
29 sporotrichosis 10.1
30 trypanosomiasis 10.1 CCL5 IFNG IL1B
31 proteasome-associated autoinflammatory syndrome 1 10.1 CCL5 IFNG IL1B
32 septic arthritis 10.1
33 bone inflammation disease 10.1 IFNG IL1B TIMP1
34 hemangioma 10.1
35 fibroma 10.1
36 fibromatosis 10.1
37 ledderhose disease 10.1
38 periodontal disease 10.1 DEFB4A IL1B TIMP1
39 respiratory system disease 10.1 CCL5 IFNG IL1B
40 periodontitis 10.1 IFNG IL1B TIMP1
41 demyelinating disease 10.1 CCL5 IFNG IL1B
42 asymptomatic neurosyphilis 10.1 DDX41 IFNG
43 t-cell/histiocyte rich large b cell lymphoma 10.1 CD68 IFNG
44 candidiasis 10.1
45 relapsing-remitting multiple sclerosis 10.1 CCL5 IFNG TIMP1
46 cercarial dermatitis 10.0 DDX41 IL1B
47 viral infectious disease 10.0 CCL5 IFNG IL1B
48 dermatitis, atopic 10.0 CCL5 DEFB4A IFNG
49 hyperlucent lung 10.0 IFNG NELFCD
50 arthritis 10.0

Graphical network of the top 20 diseases related to Eumycotic Mycetoma:



Diseases related to Eumycotic Mycetoma

Symptoms & Phenotypes for Eumycotic Mycetoma

Drugs & Therapeutics for Eumycotic Mycetoma

Drugs for Eumycotic Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
3 Hormone Antagonists Phase 2
4 Cytochrome P-450 CYP3A Inhibitors Phase 2
5 Hormones Phase 2
6 Steroid Synthesis Inhibitors Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 2
8 Anti-Infective Agents Phase 2
9
Hydroxyitraconazole Phase 2
10 Antifungal Agents Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Eumycotic Mycetoma

Cochrane evidence based reviews: mycetoma

Genetic Tests for Eumycotic Mycetoma

Anatomical Context for Eumycotic Mycetoma

MalaCards organs/tissues related to Eumycotic Mycetoma:

42
Skin, Testes, Lung, Prostate, Breast, Bone, Heart

Publications for Eumycotic Mycetoma

Articles related to Eumycotic Mycetoma:

(show top 50) (show all 113)
# Title Authors Year
1
Surgical management of eumycetoma: experience from Gezira Mycetoma Center, Sudan. ( 30675125 )
2019
2
The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis. ( 30946748 )
2019
3
Plantar Eumycetoma by Madurella mycetomatis in a heart-transplanted patient living in Portugal. ( 29150882 )
2018
4
Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America. ( 29263207 )
2018
5
Ultrasound Assessment of a Subcutaneous Eumycetoma of the Eyebrow in an Immunocompromised Patient. ( 29338839 )
2018
6
Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. ( 29698504 )
2018
7
Isolated Primary Corneal Acremonium Eumycetoma: Case Report and Literature Review. ( 30234681 )
2018
8
Eumycetoma pedis in an Albanian farmer. ( 30566558 )
2018
9
Broncho-pleuro-cutaneous fistula and pneumothorax: Rare challenging complications of chest wall eumycetoma. ( 28957324 )
2017
10
Aspergillus: An uncommon pathogen of eumycetoma. ( 27612290 )
2017
11
PET/CT and MRI Imaging of a Eumycetoma of the Right Thigh. ( 27775941 )
2017
12
Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature. ( 27928841 )
2017
13
Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country. ( 28406907 )
2017
14
Eumycetoma caused by Trichophyton species successfully treated with terbinafine and surgery. ( 28447356 )
2017
15
Immune response in human chromoblastomycosis and eumycetoma - focusing on human interleukin-17A, interferon-gamma, tumour necrosis factor-alpha, interleukin-1 beta and human beta-defensin-2. ( 27402133 )
2016
16
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2016
17
Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication. ( 27442512 )
2016
18
Mycetoma Pulmonary Secondaries from a Gluteal Eumycetoma: An Unusual Presentation. ( 27711109 )
2016
19
Black grain eumycetoma of the breast-misdiagnosed, incidental or iatrogenic? ( 26924406 )
2016
20
Phaeoacremonium sphinctrophorum as a Novel Agent of Eumycetoma. ( 27224667 )
2016
21
A non-steroidal anti-inflammatory drug to treat eumycetoma. ( 27352758 )
2016
22
Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. ( 27434108 )
2016
23
Detection of (1→3)-β-d-Glucan in Eumycetoma Patients. ( 27440815 )
2016
24
Eumycetoma Osteomyelitis of the Calcaneus in a Child: A Radiologic-Pathologic Correlation following Total Calcanectomy. ( 26483983 )
2015
25
Eumycetoma on the foot caused by Madurella mycetomatis: amputation after significant worsening during pregnancy. ( 25178425 )
2015
26
First reported case of Aspergillus nidulans eumycetoma in a sporotrichoid distribution. ( 25267555 )
2015
27
In vitro activity of antiseptic solutions against Madurella mycetomatis: implications for eumycetoma management. ( 25429729 )
2015
28
Treatment for a eumycetoma infection caused by Aspergillus in an immunocompromised host: a case report. ( 25537527 )
2015
29
In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals. ( 25631481 )
2015
30
Eumycetoma and actinomycetoma--an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy. ( 25726758 )
2015
31
Atypical craniocerebral eumycetoma: A case report and review of literature. ( 25767591 )
2015
32
The in vitro antifungal activity of sudanese medicinal plants against Madurella mycetomatis, the eumycetoma major causative agent. ( 25768115 )
2015
33
Efficient staining of actinomycetoma and eumycetoma grains using henna extract. ( 26052737 )
2015
34
Black grain eumycetoma of the breast misdiagnosed as fibroadenoma. ( 26261141 )
2015
35
Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry. ( 26497138 )
2015
36
Case report: Eumycetoma and mycotic arthritis of the knee caused by Arthrographis kalrae. ( 26719609 )
2015
37
Coexistent actinomycosis and eumycetoma in an immunocompetent patient. ( 25071271 )
2014
38
Oral eumycetoma of infancy: a rare presentation and a brief review. ( 23522832 )
2014
39
Curvularia lunata: a rare cause of black-grain eumycetoma. ( 24139180 )
2014
40
The combination of amoxicillin-clavulanic acid and ketoconazole in the treatment of Madurella mycetomatis eumycetoma and Staphylococcus aureus co-infection. ( 24945499 )
2014
41
Last generation triazoles for imported eumycetoma in eleven consecutive adults. ( 25299610 )
2014
42
Rapid identification of black grain eumycetoma causative agents using rolling circle amplification. ( 25474355 )
2014
43
Revision of agents of black-grain eumycetoma in the order Pleosporales. ( 25737597 )
2014
44
Scedosporium apiospermum eumycetoma successfully treated with oral voriconazole: report of a case and review of the Brazilian reports on scedosporiosis. ( 23563766 )
2013
45
Association of eumycetoma and schistosomiasis. ( 23717704 )
2013
46
Canine eumycetoma caused by Cladophialophora bantiana in a Maltese: case report and literature review. ( 23294374 )
2013
47
An unusual case of eumycetoma caused by Exophiala jeanselmei after a sea urchin injury. ( 23406480 )
2013
48
Oral cavity eumycetoma: a rare and unusual condition. ( 23522651 )
2013
49
Erratum to "A Rare Presentation of Concurrent Scedosporium apiospermum and Madurella grisea Eumycetoma in an Immunocompetent Host". ( 23533896 )
2013
50
Eumycetoma of the foot caused by Exophiala jeanselmei in a Guinean woman. ( 23871385 )
2013

Variations for Eumycotic Mycetoma

Expression for Eumycotic Mycetoma

Search GEO for disease gene expression data for Eumycotic Mycetoma.

Pathways for Eumycotic Mycetoma

GO Terms for Eumycotic Mycetoma

Cellular components related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL5 CHIA CHIT1 DEFB4A IFNG IL1B
2 extracellular space GO:0005615 9.32 ACTB CCL5 CHIA CHIT1 DEFB4A IFNG

Biological processes related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.92 CHIA DDX41 IFNG IL1B RPS3
2 inflammatory response GO:0006954 9.84 CCL5 CHIA IL1B IL37
3 regulation of signaling receptor activity GO:0010469 9.8 CCL5 IFNG IL1B IL37 TIMP1
4 cytokine-mediated signaling pathway GO:0019221 9.78 CCL5 IL1B IL37 TIMP1
5 response to virus GO:0009615 9.69 CCL5 IFNG TPT1
6 neutrophil chemotaxis GO:0030593 9.63 CCL5 IL1B IL37
7 regulation of insulin secretion GO:0050796 9.61 CCL5 IFNG IL1B
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.49 IFNG IL1B
9 polysaccharide digestion GO:0044245 9.37 CHIA CHIT1
10 chitin catabolic process GO:0006032 9.32 CHIA CHIT1
11 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IFNG IL1B
12 chitin metabolic process GO:0006030 9.16 CHIA CHIT1
13 immune response GO:0006955 9.1 CCL5 CHIT1 DEFB4A IFNG IL1B IL37
14 polysaccharide catabolic process GO:0000272 8.96 CHIA CHIT1

Molecular functions related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.32 CHIA CHIT1
2 interleukin-1 receptor binding GO:0005149 9.26 IL1B IL37
3 chitin binding GO:0008061 9.16 CHIA CHIT1
4 cytokine activity GO:0005125 9.02 CCL5 IFNG IL1B IL37 TIMP1
5 chitinase activity GO:0004568 8.96 CHIA CHIT1

Sources for Eumycotic Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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