MCID: EMY001
MIFTS: 38

Eumycotic Mycetoma

Categories: Infectious diseases

Aliases & Classifications for Eumycotic Mycetoma

MalaCards integrated aliases for Eumycotic Mycetoma:

Name: Eumycotic Mycetoma 12 15
Eumycetoma 12 76 73
Maduromycosis 12 73
Mycetoma 44 73
Maduromycosis, Mycotic 12
Mycotic Mycetoma 12
Mycetoma of Foot 73
Madura Foot 12

Classifications:



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Disease Ontology 12 DOID:13078
ICD10 33 B47 B47.9 B47.0
MeSH 44 D008271
NCIt 50 C85505
SNOMED-CT 68 187497002 410039003

Summaries for Eumycotic Mycetoma

Disease Ontology : 12 A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules.

MalaCards based summary : Eumycotic Mycetoma, also known as eumycetoma, is related to mycetoma and dermatomycosis. An important gene associated with Eumycotic Mycetoma is RPS3 (Ribosomal Protein S3), and among its related pathways/superpathways are NF-kappaB Signaling and Rheumatoid arthritis. The drugs Itraconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone.

Wikipedia : 76 Eumycetoma is a chronic granulomatous fungal disease of humans, affecting mainly the limbs, and... more...

Related Diseases for Eumycotic Mycetoma

Diseases related to Eumycotic Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 mycetoma 31.1 CCL5 CR1 TPT1
2 dermatomycosis 10.9 CHIA RPS3
3 fusariosis 10.8 IFNG TEF
4 parapharyngeal meningioma 10.8 CR1 SMUG1
5 cardiovascular syphilis 10.7 DDX41 SMUG1
6 gastrointestinal tuberculosis 10.6 IFNG SMUG1
7 staphylococcal toxic shock syndrome 10.6 IFNG IL1B
8 autoimmune myocarditis 10.6 IFNG IL1B
9 african tick-bite fever 10.6 CCL5 IFNG
10 von economo's disease 10.6 ACTB DDX41
11 folliculitis 10.5 CCL5 DEFB4A IFNG
12 salmonellosis 10.5 DEFB4A IFNG IL1B
13 intestinal disease 10.4 DEFB4A IFNG IL1B
14 pulmonary artery leiomyosarcoma 10.4 CD68 SMUG1
15 sternum cancer 10.4 CD68 SMUG1
16 temporal arteritis 10.4 CCL5 IFNG SMUG1
17 primary bacterial infectious disease 10.3 DDX41 IFNG IL1B
18 gastrointestinal system disease 10.3 IFNG IL1B TEF
19 hypersensitivity reaction disease 10.3 DDX41 IFNG IL1B
20 neuritis 10.3 CCL5 IFNG IL1B
21 immune system disease 10.3 DDX41 IFNG IL1B
22 autoinflammation, lipodystrophy, and dermatosis syndrome 10.3 CCL5 IFNG IL1B
23 helicobacter pylori infection 10.3 CCL5 IFNG IL1B
24 brain sarcoma 10.3 CD68 SMUG1
25 respiratory system disease 10.3 CCL5 IFNG IL1B
26 trypanosomiasis 10.3 CCL5 IFNG IL1B
27 t-cell/histiocyte rich large b cell lymphoma 10.2 CD68 CR1 IFNG
28 dendritic cell tumor 10.2 CD68 CR1 IFNG
29 relapsing-remitting multiple sclerosis 10.2 CCL5 IFNG TIMP1
30 bone inflammation disease 10.2 IFNG IL1B TIMP1
31 sarcoidosis 1 10.2 CCL5 IFNG IL1B
32 campylobacteriosis 10.2 IFNG IL1B
33 demyelinating disease 10.2 CCL5 IFNG IL1B
34 central nervous system disease 10.2 IFNG IL1B SMUG1
35 lactocele 10.2 CD68 SMUG1
36 periodontitis 10.1 IFNG IL1B TIMP1
37 nervous system disease 10.1 IFNG IL1B SMUG1
38 granulomatous myositis 10.1 CD68 SMUG1
39 hyperlucent lung 10.1 IFNG NELFCD
40 periodontal disease 10.1 DEFB4A IL1B TIMP1
41 systemic lupus erythematosus 10.1
42 lupus erythematosus 10.1
43 viral infectious disease 10.1 CCL5 IFNG IL1B
44 pericoronitis 10.0 CD68 IL1B
45 endometrial small cell carcinoma 9.9 SMUG1 UBC
46 parasitic ichthyosporea infectious disease 9.8 CD68 UBC
47 interstitial lung disease 9.8 CCL5 IFNG IL1B TIMP1
48 pericardial tuberculosis 9.8 IFNG NELFCD SMUG1
49 scrotal carcinoma 9.8 CD68 SMUG1
50 pulmonary fibrosis, idiopathic 9.8 CCL5 IFNG IL1B TIMP1

Graphical network of the top 20 diseases related to Eumycotic Mycetoma:



Diseases related to Eumycotic Mycetoma

Symptoms & Phenotypes for Eumycotic Mycetoma

Drugs & Therapeutics for Eumycotic Mycetoma

Drugs for Eumycotic Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3 Antifungal Agents Phase 2
4 Anti-Infective Agents Phase 2
5 Cytochrome P-450 CYP3A Inhibitors Phase 2
6 Cytochrome P-450 Enzyme Inhibitors Phase 2
7 Hormone Antagonists Phase 2
8 Hormones Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10
Hydroxyitraconazole Phase 2
11 Steroid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Eumycotic Mycetoma

Cochrane evidence based reviews: mycetoma

Genetic Tests for Eumycotic Mycetoma

Anatomical Context for Eumycotic Mycetoma

MalaCards organs/tissues related to Eumycotic Mycetoma:

41
Testes, Skin, Bone

Publications for Eumycotic Mycetoma

Articles related to Eumycotic Mycetoma:

(show all 11)
# Title Authors Year
1
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2015
2
Eumycotic mycetoma caused by Madurella mycetomatis successfully treated with antifungals, surgery, and topical negative pressure therapy. ( 19335427 )
2009
3
Cytodiagnosis of eumycotic mycetoma: a case report. ( 18540305 )
2008
4
Eumycotic mycetoma caused by Cladophialophora bantiana in a patient with systemic lupus erythematosus. ( 15858506 )
2005
5
Eumycotic mycetoma in the leg with a bone cyst in fibula. ( 17656929 )
2002
6
Eumycotic mycetoma caused by Pseudallescheria boydii in a dog. ( 2466820 )
1989
7
Eumycotic mycetoma caused by Pseudallescheria boydii in the abdominal cavity of a dog. ( 3343183 )
1988
8
Eumycotic mycetoma: review and report of a cutaneous lesion caused by Pseudallescheria boydii in a horse. ( 3319985 )
1987
9
Eumycotic mycetoma due to Madurella grisea. ( 3753354 )
1986
10
Eumycotic mycetoma due to Drechslera rostrata infection in a cow. ( 561594 )
1977
11
Eumycotic mycetoma in a dog caused by Allescheria boydii. ( 4920066 )
1970

Variations for Eumycotic Mycetoma

Expression for Eumycotic Mycetoma

Search GEO for disease gene expression data for Eumycotic Mycetoma.

Pathways for Eumycotic Mycetoma

Pathways related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.27 CCL5 IFNG IL1B TPT1
2 11.53 CCL5 IFNG IL1B
3 11.48 ACTB IFNG IL1B
4 11.3 CCL5 IL1B TIMP1
5 11.12 CCL5 IL1B TIMP1
6 11.02 CR1 IFNG IL1B
7 10.81 ACTB IFNG IL1B
8 10.64 CD68 IL1B
9 10.2 IFNG IL1B TIMP1

GO Terms for Eumycotic Mycetoma

Cellular components related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 ACTB CCL5 CHIA DEFB4A IFNG IL1B

Biological processes related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.85 CHIA DDX41 IFNG IL1B RPS3
2 cytokine-mediated signaling pathway GO:0019221 9.73 CCL5 IL1B TIMP1 UBC
3 immune response GO:0006955 9.55 CCL5 CHIA DEFB4A IFNG IL1B
4 response to virus GO:0009615 9.54 CCL5 IFNG TPT1
5 regulation of type I interferon production GO:0032479 9.4 DDX41 UBC
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 IFNG IL1B
7 regulation of regulatory T cell differentiation GO:0045589 9.26 CR1 IFNG
8 regulation of insulin secretion GO:0050796 9.13 CCL5 IFNG IL1B
9 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Molecular functions related to Eumycotic Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA N-glycosylase activity GO:0019104 8.96 RPS3 SMUG1
2 cytokine activity GO:0005125 8.92 CCL5 IFNG IL1B TIMP1

Sources for Eumycotic Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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