MCID: ENC002
MIFTS: 19

Eunuchism

Categories: Endocrine diseases

Aliases & Classifications for Eunuchism

MalaCards integrated aliases for Eunuchism:

Name: Eunuchism 12 45 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5003
MeSH 45 D005058
UMLS 74 C0238117

Summaries for Eunuchism

Disease Ontology : 12 A hypogonadism that is characterized by the lack of mature male germ cells and testicular hormones.

MalaCards based summary : Eunuchism is related to hypogonadotropic hypogonadism 23 without anosmia and hypogonadism. The drugs Testosterone and Methyltestosterone have been mentioned in the context of this disorder. Affiliated tissues include testes and bone.

Related Diseases for Eunuchism

Graphical network of the top 20 diseases related to Eunuchism:



Diseases related to Eunuchism

Symptoms & Phenotypes for Eunuchism

Drugs & Therapeutics for Eunuchism

Drugs for Eunuchism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-22-0, 481-30-1 10204 6013
2
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-18-4 6010
3
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 5949-44-0
4
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 315-37-7 9416
5
Polyestradiol phosphate Approved Phase 4 28014-46-2
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Anabolic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Testosterone 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Insulin, Globin Zinc Phase 4
15 insulin Phase 4
16 Follicle Stimulating Hormone Phase 4
17 Estradiol 3-benzoate Phase 4
18 Estradiol 17 beta-cypionate Phase 4
19 Pharmaceutical Solutions Phase 4
20
Coal tar Approved Phase 3 8007-45-2
21
Sodium Citrate Approved, Investigational Phase 2 68-04-2
22
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
23
Dutasteride Approved, Investigational Phase 2,Phase 1 164656-23-9 6918296 152945
24
Dihydrotachysterol Approved Phase 2,Phase 1 67-96-9 5311071 5281010
25
Finasteride Approved Phase 2 98319-26-7 57363
26
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
27
tannic acid Approved Phase 1, Phase 2 1401-55-4
28
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
29
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
30
Enclomiphene Investigational Phase 2 15690-57-0
31 Estrogen Receptor Antagonists Phase 2
32 Selective Estrogen Receptor Modulators Phase 2
33 Anticoagulants Phase 2
34 Zuclomiphene Phase 2
35 Chelating Agents Phase 2
36 Calcium, Dietary Phase 2
37 Estrogens Phase 2
38 Citrate Phase 2
39 Fertility Agents Phase 2
40 Clomiphene Phase 2
41 Estrogen Antagonists Phase 2
42 Estrogen Receptor Modulators Phase 2
43 Aromatase Inhibitors Phase 2
44 Steroid Synthesis Inhibitors Phase 2,Phase 1
45 5-alpha Reductase Inhibitors Phase 2,Phase 1
46 Deslorelin Investigational, Vet_approved Not Applicable 57773-65-6
47 Chorionic Gonadotropin

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Subcutaneous vs. Intramuscular Testosterone Completed NCT03091348 Phase 4 Testosterone
2 Study on Effects of Testosterone Replacement Therapy in Hypogonadal Type 2 Diabetic Patients" (SETH2) Completed NCT03792321 Phase 4 Testosterone Undecanoate;Placebo
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 Periodontal Profile of Hypogonadic Men Recruiting NCT03176537 Phase 4 Testosterone gel;Placebos
5 Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Obese Men With T2DM and Hypogonadism Not yet recruiting NCT03851627 Phase 4 Testosterone Undecanoate;Placebo
6 Safety and Efficacy of Oral LPCN 1021 in Men With Low Testosterone or Hypogonadism Completed NCT02081300 Phase 3 Oral testosterone undecanoate, LPCN 1021;Topical testosterone gel 1.62 %
7 Ambulatory Blood Pressure Monitoring in Oral Testosterone Undecanoate (TU, LPCN 1021) Treated Hypogonadal Men Completed NCT03868059 Phase 3 LPCN 1021
8 Dosing Validation Study of Oral Testosterone Undecanoate (TU, LPCN 1021). Completed NCT03242590 Phase 3 LPCN 1021
9 Dosing Flexibility Study of Oral Testosterone Undecanoate (TU, LPCN 1021) Completed NCT03242408 Phase 3 LPCN 1021
10 Safety and Efficacy Trial of Testosterone Undecanoate Completed NCT01765179 Phase 3 Oral testosterone undecanoate
11 Safety and Efficacy of Intranasal TBS-1 Treatment of Male Hypogonadism Completed NCT01446042 Phase 3 Testosterone;Testosterone
12 Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal Men Completed NCT01403116 Phase 3 Oral testosterone undecanoate;topical testosterone gel
13 Efficacy and Safety of Oral Testosterone Undecanoate in Hypogonadal Men Recruiting NCT03198728 Phase 3 SOV2012-F1;AndroGel
14 Clomid in Men With Low Testosterone With and Without Prior Treatment Unknown status NCT01904734 Phase 2 Clomiphene
15 Anastrazole and Clomiphene to Evaluate Hypogonadal Symptoms and Erectile Function Completed NCT03933618 Phase 2 Anastrozole 1mg;Clomiphene Citrate 25mg;Placebo - Cap
16 28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men Completed NCT00398580 Phase 2 Nanomilled testosterone;Nanomilled dutasteride;commercially available dutasteride
17 5-Alpha Reductase and Anabolic Effects of Testosterone Completed NCT00475501 Phase 2 Testosterone Enanthate;Finasteride
18 A Phase 1/2a Study to Determine the Dose Response Pharmacokinetics of TSX-011 (Testosterone Undecanoate) in Hypogonadal Males Terminated NCT03335254 Phase 1, Phase 2 TSX-011
19 Study On Bioavailability And Pharmacokinetics Of Various Doses Of Testosterone Administered With And Without Dutasteride Completed NCT00400335 Phase 1 Nanomilled testosterone;commercially available dutasteride;Nanomilled dutasteride
20 Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males Completed NCT03541395 Not Applicable GnRH antagonist
21 Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male Recruiting NCT03282682 Not Applicable
22 Calciotropic Effects After hCG Stimulation Test Active, not recruiting NCT03254641 human chorionic gonadotropin
23 Gonadal Function in Young to Middle Aged HIV-infected Men Active, not recruiting NCT03747003

Search NIH Clinical Center for Eunuchism

Cochrane evidence based reviews: eunuchism

Genetic Tests for Eunuchism

Anatomical Context for Eunuchism

MalaCards organs/tissues related to Eunuchism:

42
Testes, Bone

Publications for Eunuchism

Articles related to Eunuchism:

# Title Authors Year
1
Congenital eunuchism and Favorinus. ( 12564336 )
2003
2
Eunuchs and eunuchism - an historical discourse. Part II - Civil law. ( 11611120 )
1982
3
Eunuchs and eunuchism--an historical discourse. ( 11610953 )
1981
4
Serum inorganic phosphorus levels in eunuchism and in feeble-minded states. ( 13502447 )
1958
5
Anorchism without eunuchism. ( 13346829 )
1956
6
Clinical and endocrinological investigations in a case of eunuchism (gigantism with hypogonadism). ( 14877571 )
1951
7
Male Eunuchism Considered in the Light of the Historical Method. ( 19993336 )
1946
8
The cultural aspects of eunuchism. ( 20276292 )
1946

Variations for Eunuchism

Expression for Eunuchism

Search GEO for disease gene expression data for Eunuchism.

Pathways for Eunuchism

GO Terms for Eunuchism

Sources for Eunuchism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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