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MCID: ENC002
MIFTS: 25

Eunuchism

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Eunuchism

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MalaCards integrated aliases for Eunuchism:

Name: Eunuchism 12 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5003
MeSH 43 D005058
SNOMED-CT 67 267403002
UMLS 71 C0238117
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Summaries for Eunuchism

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Disease Ontology : 12 A hypogonadism that is characterized by the lack of mature male germ cells and testicular hormones.

MalaCards based summary : Eunuchism is related to kallmann syndrome and hypogonadotropic hypogonadism 23 without anosmia. An important gene associated with Eunuchism is SHOX (Short Stature Homeobox). The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include testes and testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Eunuchism

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Diseases related to Eunuchism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 kallmann syndrome 29.0 STS SHOX GNRH1
2 hypogonadotropic hypogonadism 23 without anosmia 12.3
3 hypogonadism 10.5
4 hypogonadotropic hypogonadism 10.3
5 gout 10.3
6 aortic valve disease 1 10.1
7 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 10.1
8 hypogonadotropic hypogonadism 7 with or without anosmia 10.1
9 osteoporosis 10.1
10 prostate cancer 10.1
11 hypogonadotropic hypogonadism 1 with or without anosmia 10.1
12 myocardial infarction 10.1
13 bone mineral density quantitative trait locus 8 10.1
14 bone mineral density quantitative trait locus 15 10.1
15 paraphilia disorder 10.1
16 mumps 10.1
17 transsexualism 10.1
18 clubfoot 10.1
19 impotence 10.1
20 orchitis 10.1
21 oral submucous fibrosis 10.1
22 isolated gonadotropin-releasing hormone deficiency 10.1
23 gigantism 10.1
24 leukoplakia 10.1
25 congenital hypogonadotropic hypogonadism 10.1
26 normosmic congenital hypogonadotropic hypogonadism 10.1
27 chondrodysplasia punctata syndrome 9.8 STS SHOX
28 acute endometritis 9.6 IFI30 GNRH1
29 vaginal discharge 9.6 IFI30 GNRH1
30 endometrial disease 9.4 IFI30 GNRH1
31 disorders of sexual development 9.4 SHOX GNRH1

Graphical network of the top 20 diseases related to Eunuchism:



Diseases related to Eunuchism
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Symptoms & Phenotypes for Eunuchism

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GenomeRNAi Phenotypes related to Eunuchism according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.75 AGO2 SHOX
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.75 AGO2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.75 AGO2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.75 KIR2DL4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.75 SHOX
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.75 KIR2DL4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.75 AGO2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.75 IFI30
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.75 SHOX
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.75 AGO2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-151 9.75 IFI30
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.75 KIR2DL4 SHOX
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 9.75 AGO2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-158 9.75 AGO2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 9.75 KIR2DL4
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.75 SHOX
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.75 SHOX
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-24 9.75 SHOX
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.75 KIR2DL4
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.75 SHOX
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.75 KIR2DL4
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.75 AGO2
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.75 KIR2DL4
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.75 KIR2DL4
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.75 KIR2DL4
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Drugs & Therapeutics for Eunuchism

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Drugs for Eunuchism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 4 28014-46-2
3 Insulin, Globin Zinc Phase 4
4 insulin Phase 4
5 Estradiol 17 beta-cypionate Phase 4
6 Estradiol 3-benzoate Phase 4
7 Follicle Stimulating Hormone Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Anabolic Agents Phase 4
10 Pharmaceutical Solutions Phase 4
11
Dutasteride Approved, Investigational Phase 2 164656-23-9 152945 6918296
12
Dihydrotachysterol Approved Phase 2 67-96-9 5311071 5281010
13
Sodium citrate Approved, Investigational Phase 2 68-04-2
14
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
15
tannic acid Approved Phase 1, Phase 2 1401-55-4
16
Benzocaine Approved, Investigational Phase 1, Phase 2 94-09-7, 1994-09-7 2337
17
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
18
Enclomiphene Investigational Phase 2 15690-57-0
19 5-alpha Reductase Inhibitors Phase 2
20 Citrate Phase 2
21 Estrogen Antagonists Phase 2
22 Estrogen Receptor Antagonists Phase 2
23 Estrogen Receptor Modulators Phase 2
24 Clomiphene Phase 2
25 Estrogens Phase 2
26 Aromatase Inhibitors Phase 2
27 Zuclomiphene Phase 2
28 Chorionic Gonadotropin

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Study on Effects of Testosterone Replacement Therapy in Hypogonadal Type 2 Completed NCT03792321 Phase 4 Testosterone Undecanoate;Placebo
2 Subcutaneous Testosterone Therapy in Men Compared to Intramuscular Testosterone Therapy in Men Completed NCT03091348 Phase 4 Testosterone
3 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Completed NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
4 A Comparison of Side Effects in Hypogonadal Men Treated With Natesto Versus Testosterone Injections: A Phase IV, Prospective, Randomized, Non-Blinded, Multi-Institutional Study Not yet recruiting NCT04439799 Phase 4 Testosterone Cypionate 200 MG/ML;Intranasal Testosterone
5 52 Week RCT to Investigate the Effect of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Obese Men With T2DM and Hypogonadism and Subsequent 108 Week Open Label Phase to Investigate Effects on Cardiometabolic Parameters Not yet recruiting NCT03851627 Phase 4 Testosterone Undecanoate;Placebo
6 Clinical, Microbiologic and Immunologic Profile of the Periodontal Condition in Hypogonadic Men Withdrawn NCT03176537 Phase 4 Testosterone gel;Placebos
7 Validation of Dosing Regimen of Oral Testosterone Undecanoate (TU, LPCN 1021) in Hypogonadal Men. Completed NCT03242590 Phase 3 LPCN 1021
8 Dosing Flexibility Study of Oral Testosterone Undecanoate (TU, LPCN 1021) in Hypogonadal Men. Completed NCT03242408 Phase 3 LPCN 1021
9 A 90-Day, Randomized, Dose-Ranging Study, Including Potential Dose Titration, Evaluating the Efficacy and Safety of Intranasal TBS-1 in the Treatment of Male Hypogonadism With Sequential Safety Extension Periods of 90 and 180 Days Completed NCT01446042 Phase 3 Testosterone;Testosterone
10 Phase 3, Active-Controlled, Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU, LPCN 1021) in Hypogonadal Men Completed NCT02081300 Phase 3 Oral testosterone undecanoate, LPCN 1021;Topical testosterone gel 1.62 %
11 Ambulatory Blood Pressure Monitoring in Oral Testosterone Undecanoate (TU, LPCN 1021) Treated Hypogonadal Men Completed NCT03868059 Phase 3 LPCN 1021
12 A 12-Month, Randomized, Active-controlled, Open-label Study of the Efficacy and Safety of Oral Testosterone Undecanoate in Hypogonadal Men (RE-TUne) Recruiting NCT03198728 Phase 3 SOV2012-F1;AndroGel
13 A Comparison of Clomiphene Citrate Responses in Men With Hypothalamic Hypogonadism naïve to, and Previously Treated With, Testosterone Unknown status NCT01904734 Phase 2 Clomiphene
14 A Phase II, 28-Day, Randomized, Parallel-Group, Open-Label Study Evaluating the Efficacy and Safety of Twice Daily Oral Doses of Testosterone (150-400mg) Co-administered With 0.25mg Dutasteride Compared With 400mg Testosterone Alone and 0.25mg Dutasteride Alone in the Treatment of Hypogonadism Completed NCT00398580 Phase 2 Nanomilled testosterone;Nanomilled dutasteride;commercially available dutasteride
15 A Randomized Double Blinded Placebo Controlled Trial Between Anastrozole and Clomiphene to Evaluate Improvement in Hypogonadal Symptoms and Erectile Function Using ADAM, IIEF and EHS Validated Scales Completed NCT03933618 Phase 2 Anastrozole 1mg;Clomiphene Citrate 25mg;Placebo - Cap
16 Improving Patient-Important Outcomes With Testosterone Replacement in Hypogonadal Men With a Prior History of Cancer Recruiting NCT04049331 Phase 2 Testosterone cypionate 125 mg/week
17 Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency Not yet recruiting NCT04301765 Phase 2 testosterone 1.62% gel
18 A Phase 1/2a Study to Determine the Dose Response Pharmacokinetics of TSX-011 (Testosterone Undecanoate) in Hypogonadal Males Terminated NCT03335254 Phase 1, Phase 2 TSX-011
19 An Open Label Study to Evaluate the Impact of Novel Fixed-dose Testosterone/Dutasteride Combinations on the Relative Bioavailability of the Individual Dutasteride and Testosterone Components Completed NCT00400335 Phase 1 Nanomilled testosterone;commercially available dutasteride;Nanomilled dutasteride
20 A Study to Assess Post-collection Conversion of Testosterone Undecanoate (TU) to Testosterone in Blood From Men Receiving Oral TU Collected Into Different Types of Sample Tubes Completed NCT03973840 Phase 1 Testosterone Undecanoate
21 Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males Before and After Pharmacological Castration Completed NCT03541395 GnRH antagonist
22 Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male (ADAM) Completed NCT03282682
23 Gonadal Function in Young to Middle Aged HIV-infected Men Assessed by Isotopic Dilution-liquid Chromatography-mass Spectrometry (ID-LC-MS/MS) and Chemiluminescent Immunoassay Active, not recruiting NCT03747003
24 Calciotropic Effects After hCG Stimulation Test Active, not recruiting NCT03254641 human chorionic gonadotropin
25 Salivary Testosterone in Men: Diurnal Variation and Post-prandial Responses Not yet recruiting NCT04326673

Search NIH Clinical Center for Eunuchism

Cochrane evidence based reviews: eunuchism

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Genetic Tests for Eunuchism

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Anatomical Context for Eunuchism

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MalaCards organs/tissues related to Eunuchism:

40
Testes, Testis
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Publications for Eunuchism

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Articles related to Eunuchism:

(show all 29)
# Title Authors PMID Year
1
[Henry IV of Castilla (1454-1474). An exceptional urologic patient. An endocrinopathy causing the uro-andrological problems of the Monarch. Artificial insemination attempts (IV)]. 61
12768985 2003
2
Congenital eunuchism and Favorinus. 61
12564336 2003
3
[Eunuchism in Byzantium]. 61
11761705 2001
4
Hemicorporectomy. 61
7712321 1995
5
Eunuchs and eunuchism - an historical discourse. Part II - Civil law. 61
11611120 1982
6
[Hypogonadism with spermatogenesis (fertile eunuch syndrome) (author's transl)]. 61
6283650 1982
7
Eunuchs and eunuchism--an historical discourse. 61
11610953 1981
8
[Myocardial infarct with failure of mitral valve papillary muscle in a case of eunuchism]. 61
463000 1979
9
[Is eunuchism a question of testostererone deficiency?]. 61
5561796 1971
10
[Feminine hypogonadotrophic eunuchism]. 61
5495948 1970
11
[An XY eunuchism syndrome with preserved spermatogenesis and normal secretion of FSH, ICSH and testosterone. Preliminary report]. 61
5408621 1969
12
[Different histological patterns of the testis in cases of hypogonadotrophic eunuchism]. 61
5407617 1969
13
[Eunuchism with spermatogenesis; a rare cause of male subfertility]. 61
5679596 1968
14
[Histopathologic pictures of testes in hypogonadotropic eunuchism]. 61
6050709 1967
15
[Hypogonadotropic eunuchism in women]. 61
6050708 1967
16
[Idiopathic hypogonadotrophic eunuchism and anosmia]. 61
5302876 1967
17
[IDIOPATHIC HYPOGONADOTROPIC EUNUCHISM. STUDY OF 24 CASES]. 61
14202711 1964
18
[APROPOS OF A CASE OF LOBSTEIN'S DISEASE ASSOCIATED WITH A EUNUCHISM SECONDARY TO A CRYPTORCHISM]. 61
14144046 1964
19
[Therapy of eunuchism]. 61
13985337 1962
20
Serum inorganic phosphorus levels in eunuchism and in feeble-minded states. 61
13502447 1958
21
Anorchism without eunuchism. 61
13346829 1956
22
[Hypergonadotropic eunuchism (Klinefelter syndrome)]. 61
13349173 1956
23
[A case of hypogonadotrophic female eunuchism; ovarian biopsy]. 61
13181045 1954
24
Clinical and endocrinological investigations in a case of eunuchism (gigantism with hypogonadism). 61
14877571 1951
25
[Osteoporosis in eunuchism]. 61
14793841 1950
26
[Diffuse decalcifying osteosis and eunuchism]. 61
15441783 1950
27
The clinical significance of urinary 17-ketosteroid assays. 61
15405026 1950
28
The cultural aspects of eunuchism. 61
20276292 1946
29
Male Eunuchism Considered in the Light of the Historical Method. 61
19993336 1946
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Variations for Eunuchism

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Expression for Eunuchism

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Search GEO for disease gene expression data for Eunuchism.
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Pathways for Eunuchism

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GO Terms for Eunuchism

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Biological processes related to Eunuchism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 8.62 STS GNRH1

Molecular functions related to Eunuchism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TTR GNRH1
Sources

Sources for Eunuchism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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