Eustachian Tube Disease

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Disease Ontology 12 DOID:9739 ICD9CM 35 381.8 381.89

ICD10 33 H69 H69.8 UMLS 73 C0155435 C0271468

Disease Ontology : ¹² A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation.

MalaCards based summary : Eustachian Tube Disease, also known as eustachian tube disorder, is related to otitis media and tympanosclerosis. An important gene associated with Eustachian Tube Disease is PGRMC1 (Progesterone Receptor Membrane Component 1). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.53	CANX
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-108	9.53	CDK9
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.53	CANX CDK9
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.53	CANX
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.53	CDK9
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-159	9.53	CDK9
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.53	CANX
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.53	CDK9
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	9.53	CANX
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	9.53	CDK9
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.53	CDK9
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	9.53	CANX
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-4	9.53	CDK9
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.53	CANX
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.53	CANX
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-116	9.43	CANX CDK9
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-139	9.43	CANX
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-27	9.43	CDK9
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-34	9.43	CDK9
20	Decreased shRNA abundance (Z-score < -2)	GR00366-A-86	9.43	CDK9

Search Clinical Trials , NIH Clinical Center for Eustachian Tube Disease

Search GEO for disease gene expression data for Eustachian Tube Disease.