MCID: EST006
MIFTS: 18

Eustachian Tube Disease

Categories: Ear diseases

Aliases & Classifications for Eustachian Tube Disease

MalaCards integrated aliases for Eustachian Tube Disease:

Name: Eustachian Tube Disease 12 15 17
Eustachian Tube Disorder 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9739
ICD9CM 36 381.8 381.89
ICD10 34 H69 H69.8

Summaries for Eustachian Tube Disease

Disease Ontology : 12 A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation.

MalaCards based summary : Eustachian Tube Disease, also known as eustachian tube disorder, is related to otitis media and tympanosclerosis. An important gene associated with Eustachian Tube Disease is PGRMC1 (Progesterone Receptor Membrane Component 1). The drugs Triamcinolone and Triamcinolone hexacetonide have been mentioned in the context of this disorder. Affiliated tissues include testes.

Related Diseases for Eustachian Tube Disease

Diseases related to Eustachian Tube Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 otitis media 10.0
2 tympanosclerosis 10.0
3 middle ear disease 10.0

Symptoms & Phenotypes for Eustachian Tube Disease

Drugs & Therapeutics for Eustachian Tube Disease

Drugs for Eustachian Tube Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 3,Not Applicable 124-94-7 31307
2 Triamcinolone hexacetonide Phase 3,Not Applicable
3 triamcinolone acetonide Phase 3,Not Applicable
4 Triamcinolone diacetate Phase 3,Not Applicable
5 Pharmaceutical Solutions Phase 3
6 glucocorticoids Phase 3
7 Immunosuppressive Agents Phase 3
8 Hormone Antagonists Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Immunologic Factors Phase 3
12 Hormones Phase 3
13
Calcium Carbonate Approved, Investigational Phase 2 471-34-1
14
Simethicone Approved Phase 2 8050-81-5
15
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
16 Dermatologic Agents Phase 2
17 Calcium, Dietary Phase 2
18 Emollients Phase 2
19
Cocaine Approved, Illicit Not Applicable 50-36-2 446220 5760
20
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
21
Phenylephrine Approved Not Applicable 59-42-7 6041
22
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
23
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
24
tannic acid Approved Not Applicable 1401-55-4
25 Trichostatin A Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux Withdrawn NCT02123498 Phase 4 Omeprazole;Ranitidine;Pantoprazole
2 Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays Completed NCT00279916 Phase 3 Triamcinolone acetonide nasal spray;Placebo nasal spray
3 Effect of Simethicone on Eustachian Tube Dysfunction Completed NCT01312038 Phase 2 Simethicone;Placebo
4 A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube Unknown status NCT00933478
5 Long Term Evaluation of Tubal Expansion on Obstructive Dysfunctions of Eustachian Tube Completed NCT02123277 Not Applicable
6 Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction Completed NCT02114762 Not Applicable
7 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults Completed NCT01251432
8 The Accuracy of Tests of Eustachian Tube Function Completed NCT02385175
9 Eustachian Tube Dysfunction Assessment Completed NCT02667301 Not Applicable
10 Study of Safety and Efficacy for the Eustachian Tube Balloon Catheter Completed NCT02087150 Not Applicable
11 XprESS Eustachian Tube Dilation Study Completed NCT02391584 Not Applicable
12 Novel Imaging of the Eustachian Tube; Patient Study Completed NCT02282540 Not Applicable
13 Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings Completed NCT01965457
14 A Novel Objective Diagnostic Test for Otitis Media With Effusion Completed NCT02179541
15 Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction Recruiting NCT01974726 Not Applicable
16 Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing Recruiting NCT03850197 Not Applicable
17 Correlation Analysis Between ETF and Prognosis of Tympanoplasty Recruiting NCT03424369
18 Balloon Dilation of the Eustachian Tube in Children Recruiting NCT03499015 Not Applicable
19 Safety of Intranasal Irrigation Probiotics in Healthy Volunteers Recruiting NCT02933918 Not Applicable
20 Balloon Eustachian Tuboplasty in Treatment of Chronic Eustachian Tube Dysfunction Active, not recruiting NCT03556215 Not Applicable
21 The Therapeutic Effect of BET in COM With ETD Not yet recruiting NCT03440710 Not Applicable
22 Tympanostomy Tubes Versus Eustachian Tube Dilation Not yet recruiting NCT03886740 Not Applicable
23 Balloon Dilation of the Eustachian Tube, a Lower Pressure Challenge Not yet recruiting NCT03322579 Not Applicable
24 Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate Not yet recruiting NCT03868891 Not Applicable
25 Obstructive Sleep Apnea Syndrome (OSAS) and Dizziness Not yet recruiting NCT03850353
26 Evaluating Changes in Middle Ear Pressure Caused by CPAP Terminated NCT02882022 Not Applicable
27 Refractory Eustachian Tube Dysfunction: Are the Symptoms Related to Endolymphatic Hydrops Withdrawn NCT01661777 Not Applicable Nasal steroid;Diuretic;Antihistamine
28 Feasibility Study of Balloon Eustachian Tuboplasty (BET) Withdrawn NCT02631187 Not Applicable

Search NIH Clinical Center for Eustachian Tube Disease

Genetic Tests for Eustachian Tube Disease

Anatomical Context for Eustachian Tube Disease

MalaCards organs/tissues related to Eustachian Tube Disease:

42
Testes

Publications for Eustachian Tube Disease

Articles related to Eustachian Tube Disease:

# Title Authors Year
1
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. ( 3835948 )
1985

Variations for Eustachian Tube Disease

Expression for Eustachian Tube Disease

Search GEO for disease gene expression data for Eustachian Tube Disease.

Pathways for Eustachian Tube Disease

GO Terms for Eustachian Tube Disease

Sources for Eustachian Tube Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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