MCID: EST006
MIFTS: 15

Eustachian Tube Disease

Categories: Ear diseases

Aliases & Classifications for Eustachian Tube Disease

MalaCards integrated aliases for Eustachian Tube Disease:

Name: Eustachian Tube Disease 12 15
Eustachian Tube Disorder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9739
ICD9CM 35 381.8 381.89
SNOMED-CT 68 194277003 194278008
ICD10 33 H69 H69.8

Summaries for Eustachian Tube Disease

Disease Ontology : 12 A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation.

MalaCards based summary : Eustachian Tube Disease, also known as eustachian tube disorder, is related to auditory system disease and middle ear disease. An important gene associated with Eustachian Tube Disease is PGRMC1 (Progesterone Receptor Membrane Component 1). Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Eustachian Tube Disease

Diseases related to Eustachian Tube Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 auditory system disease 9.9
2 middle ear disease 9.9
3 otitis media 9.9
4 tympanosclerosis 9.9
5 patulous eustachian tube 8.5 CANX CDK9 PGRMC1
6 non-suppurative otitis media 8.2 CANX CDK9 PGRMC1

Graphical network of the top 20 diseases related to Eustachian Tube Disease:



Diseases related to Eustachian Tube Disease

Symptoms & Phenotypes for Eustachian Tube Disease

GenomeRNAi Phenotypes related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.88 CANX
2 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.88 CDK9
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.88 CANX CDK9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.88 CANX CDK9
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.88 CANX
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.88 CDK9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.88 CDK9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.88 CANX
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.88 CDK9
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.88 CANX
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.88 CDK9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.88 CDK9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.88 CANX
14 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.88 CDK9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.88 CANX
16 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.88 CANX

Drugs & Therapeutics for Eustachian Tube Disease

Search Clinical Trials , NIH Clinical Center for Eustachian Tube Disease

Genetic Tests for Eustachian Tube Disease

Anatomical Context for Eustachian Tube Disease

Publications for Eustachian Tube Disease

Articles related to Eustachian Tube Disease:

# Title Authors Year
1
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. ( 3835948 )
1985

Variations for Eustachian Tube Disease

Expression for Eustachian Tube Disease

Search GEO for disease gene expression data for Eustachian Tube Disease.

Pathways for Eustachian Tube Disease

GO Terms for Eustachian Tube Disease

Cellular components related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.62 CANX PGRMC1

Sources for Eustachian Tube Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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