MCID: EST006
MIFTS: 27

Eustachian Tube Disease

Categories: Ear diseases

Aliases & Classifications for Eustachian Tube Disease

MalaCards integrated aliases for Eustachian Tube Disease:

Name: Eustachian Tube Disease 12 15 17
Eustachian Tube Disorder 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9739
ICD9CM 34 381.8
SNOMED-CT 67 194277003
ICD10 32 H69 H69.8 H69.9
UMLS 71 C0155435 C0271468

Summaries for Eustachian Tube Disease

Disease Ontology : 12 A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation.

MalaCards based summary : Eustachian Tube Disease, also known as eustachian tube disorder, is related to otitis media and branchiootorenal spectrum disorder. An important gene associated with Eustachian Tube Disease is SLC36A2 (Solute Carrier Family 36 Member 2). Related phenotypes are Decreased caspase 3/7 activity and behavior/neurological

Wikipedia : 74 Eustachian tube dysfunction (ETD) is defined as pressure abnormalities in the middle ear which result in... more...

Related Diseases for Eustachian Tube Disease

Diseases related to Eustachian Tube Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 otitis media 29.8 RNASE3 CCL11 C3
2 branchiootorenal spectrum disorder 10.2 SIX1 EYA1
3 non-suppurative otitis media 10.2 TFF3 SLC36A2 ARSB
4 ear malformation 10.2 EYA1 ATOH1
5 deafness, autosomal dominant 10 10.1 SIX1 EYA1
6 lateral myocardial infarction 10.1 NR3C2 C3
7 branchiootic syndrome 1 10.1 SIX1 EYA1 CDH23
8 labyrinthitis 10.1 NR3C2 ATOH1
9 inner ear disease 10.1 CDH23 CACNA1D ATOH1
10 branchiootorenal syndrome 2 10.1 SIX1 EYA1
11 serous labyrinthitis 10.0 CCL11 ATOH1
12 hereditary hearing loss and deafness 10.0 EYA1 CDH23
13 sensorineural hearing loss 10.0
14 tympanosclerosis 10.0
15 middle ear disease 10.0
16 chronic asthma 10.0 RNASE3 CCL11
17 otosalpingitis 10.0 TFF3 SLC36A2 PDE5A ARSB
18 stickler syndrome 10.0 EYA1 ELN CDH23
19 elephantiasis 10.0 RNASE3 ELN
20 autosomal dominant nonsyndromic deafness 10.0 SIX1 EYA1 CDH23 ATOH1
21 vernal keratoconjunctivitis 9.9 RNASE3 CCL11
22 pemphigoid gestationis 9.9 RNASE3 CCL11
23 giant papillary conjunctivitis 9.9 RNASE3 CCL11
24 chronic conjunctivitis 9.9 RNASE3 CCL11
25 chronic eosinophilic pneumonia 9.8 RNASE3 CCL11
26 metachromatic leukodystrophy 9.8 GDNF CDH23 ARSB
27 adhesive otitis media 9.8 RNASE3 LGALS9 CCL11
28 papillorenal syndrome 9.8 SIX1 GDNF EYA1
29 renal hypoplasia 9.8 SIX1 GDNF EYA1
30 vesicoureteral reflux 1 9.8 SIX1 GDNF EYA1
31 cakut 9.8 SIX1 GDNF EYA1
32 renal hypodysplasia/aplasia 1 9.7 SIX1 GDNF EYA1
33 eosinophilic gastroenteritis 9.6 RNASE3 CCL11
34 pulmonary disease, chronic obstructive 9.5 RNASE3 PDE5A ELN CCL11
35 patulous eustachian tube 7.8 SIX1 RNASE3 NR3C2 LGALS9 GDNF FTL

Graphical network of the top 20 diseases related to Eustachian Tube Disease:



Diseases related to Eustachian Tube Disease

Symptoms & Phenotypes for Eustachian Tube Disease

GenomeRNAi Phenotypes related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 LGALS9 NR3C2 PDE5A

MGI Mouse Phenotypes related to Eustachian Tube Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 ARSB ATOH1 C3 CACNA1D CDH23 EYA1
2 digestive/alimentary MP:0005381 9.7 ATOH1 C3 CDH23 EYA1 GDNF SIX1
3 hearing/vestibular/ear MP:0005377 9.43 ARSB ATOH1 CACNA1D CDH23 EYA1 SIX1
4 nervous system MP:0003631 9.36 ARSB ATOH1 C3 CACNA1D CDH23 EYA1

Drugs & Therapeutics for Eustachian Tube Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Evaluation of Tubal Expansion on Obstructive Dysfunctions of Eustachian Tube Completed NCT02123277
2 Evaluating Changes in Middle Ear Pressure Caused by CPAP Terminated NCT02882022

Search NIH Clinical Center for Eustachian Tube Disease

Genetic Tests for Eustachian Tube Disease

Anatomical Context for Eustachian Tube Disease

Publications for Eustachian Tube Disease

Articles related to Eustachian Tube Disease:

# Title Authors PMID Year
1
Sonotubometry: eustachian tube ventilatory function test: a state-of-the-art review. 61
15891664 2005
2
[Expert assessment within the scope of the sudden deafness disease picture]. 61
7607917 1995
3
Experiences with implantable hearing devices and a presentation of a new device. 61
3947005 1986
4
Factors influencing collagen-induced autoimmune ear disease. 61
3874564 1985
5
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. 61
3835948 1985

Variations for Eustachian Tube Disease

Expression for Eustachian Tube Disease

Search GEO for disease gene expression data for Eustachian Tube Disease.

Pathways for Eustachian Tube Disease

GO Terms for Eustachian Tube Disease

Cellular components related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TFF3 RNASE3 LGALS9 GDNF FTL ELN
2 azurophil granule lumen GO:0035578 8.92 RNASE3 FTL C3 ARSB

Biological processes related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.74 RNASE3 LGALS9 CCL11
2 inner ear morphogenesis GO:0042472 9.61 SIX1 EYA1 ATOH1
3 outflow tract morphogenesis GO:0003151 9.58 SIX1 EYA1 ELN
4 cochlea morphogenesis GO:0090103 9.56 SIX1 EYA1
5 middle ear morphogenesis GO:0042474 9.55 SIX1 EYA1
6 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.54 SIX1 GDNF
7 pharyngeal system development GO:0060037 9.52 SIX1 EYA1
8 neuron fate specification GO:0048665 9.51 SIX1 EYA1
9 branching involved in ureteric bud morphogenesis GO:0001658 9.5 SIX1 GDNF EYA1
10 aorta morphogenesis GO:0035909 9.49 SIX1 EYA1
11 organ induction GO:0001759 9.48 SIX1 GDNF
12 otic vesicle development GO:0071599 9.46 SIX1 EYA1
13 sensory perception of sound GO:0007605 9.46 SIX1 EYA1 CDH23 CACNA1D
14 ureteric bud development GO:0001657 9.43 SIX1 GDNF EYA1
15 positive regulation of ureteric bud formation GO:0072107 9.37 SIX1 GDNF
16 positive regulation of secondary heart field cardioblast proliferation GO:0072513 8.96 SIX1 EYA1
17 regulation of neuron differentiation GO:0045664 8.8 SIX1 EYA1 ATOH1

Sources for Eustachian Tube Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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