MCID: EST006
MIFTS: 23

Eustachian Tube Disease

Categories: Ear diseases

Aliases & Classifications for Eustachian Tube Disease

MalaCards integrated aliases for Eustachian Tube Disease:

Name: Eustachian Tube Disease 12 15 17
Eustachian Tube Disorder 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9739
ICD9CM 34 381.8
ICD10 32 H69 H69.8 H69.9
UMLS 71 C0155435 C0271468

Summaries for Eustachian Tube Disease

Disease Ontology : 12 A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation.

MalaCards based summary : Eustachian Tube Disease, also known as eustachian tube disorder, is related to otitis media and sensorineural hearing loss. An important gene associated with Eustachian Tube Disease is SLC36A2 (Solute Carrier Family 36 Member 2), and among its related pathways/superpathways is Amino acid transport across the plasma membrane. Affiliated tissues include testes.

Wikipedia : 74 Eustachian tube dysfunction (ETD) is defined as pressure abnormalities in the middle ear which result in... more...

Related Diseases for Eustachian Tube Disease

Diseases related to Eustachian Tube Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 otitis media 10.0
2 sensorineural hearing loss 10.0
3 tympanosclerosis 10.0
4 middle ear disease 10.0
5 salpingitis 10.0
6 vasculitis 10.0
7 otosalpingitis 9.8 SLC36A2 INTU
8 hyperglycinuria 9.6 SLC6A20 SLC36A2
9 epidemic typhus 9.6 TXNDC15 SLC36A2
10 iminoglycinuria 9.5 SLC6A20 SLC36A2
11 patulous eustachian tube 8.8 TXNDC15 SNORD79 SLC6A20 NR2F6

Graphical network of the top 20 diseases related to Eustachian Tube Disease:



Diseases related to Eustachian Tube Disease

Symptoms & Phenotypes for Eustachian Tube Disease

Drugs & Therapeutics for Eustachian Tube Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Evaluation of Tubal Expansion on Obstructive Dysfunctions of Eustachian Tube Completed NCT02123277
2 Evaluating Changes in Middle Ear Pressure Caused by CPAP Terminated NCT02882022

Search NIH Clinical Center for Eustachian Tube Disease

Genetic Tests for Eustachian Tube Disease

Anatomical Context for Eustachian Tube Disease

MalaCards organs/tissues related to Eustachian Tube Disease:

40
Testes

Publications for Eustachian Tube Disease

Articles related to Eustachian Tube Disease:

# Title Authors PMID Year
1
Sonotubometry: eustachian tube ventilatory function test: a state-of-the-art review. 61
15891664 2005
2
[Expert assessment within the scope of the sudden deafness disease picture]. 61
7607917 1995
3
Experiences with implantable hearing devices and a presentation of a new device. 61
3947005 1986
4
Factors influencing collagen-induced autoimmune ear disease. 61
3874564 1985
5
Type II collagen mediated autoimmune middle ear disease: eustachian tube disease, otitis media with effusion and tympanosclerosis. 61
3835948 1985

Variations for Eustachian Tube Disease

Expression for Eustachian Tube Disease

Search GEO for disease gene expression data for Eustachian Tube Disease.

Pathways for Eustachian Tube Disease

Pathways related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.14 SLC6A20 SLC36A2

GO Terms for Eustachian Tube Disease

Biological processes related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium assembly GO:0060271 9.43 TXNDC15 INTU
2 cell projection organization GO:0030030 9.4 TXNDC15 INTU
3 amino acid transport GO:0006865 9.37 SLC6A20 SLC36A2
4 amino acid transmembrane transport GO:0003333 9.32 SLC6A20 SLC36A2
5 positive regulation of smoothened signaling pathway GO:0045880 9.26 TXNDC15 INTU
6 glycine transport GO:0015816 9.16 SLC6A20 SLC36A2
7 proline transport GO:0015824 8.96 SLC6A20 SLC36A2
8 proline transmembrane transport GO:0035524 8.62 SLC6A20 SLC36A2

Molecular functions related to Eustachian Tube Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 8.96 SLC6A20 SLC36A2
2 L-proline transmembrane transporter activity GO:0015193 8.62 SLC6A20 SLC36A2

Sources for Eustachian Tube Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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