MCID: ETH004
MIFTS: 41

Euthyroid Sick Syndrome

Categories: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

MalaCards integrated aliases for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 12 15
Euthyroid Sick Syndromes 55 44 73
Sick-Euthyroid Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2856
ICD10 33 E07.81
ICD9CM 35 790.94
MeSH 44 D005067
NCIt 50 C113170
UMLS 73 C0015190

Summaries for Euthyroid Sick Syndrome

MalaCards based summary : Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to hypothyroidism and hyperthyroxinemia. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Lung fibrosis and Photodynamic therapy-induced NF-kB survival signaling. The drugs Magnesium oxide and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and heart, and related phenotypes are endocrine/exocrine gland and neoplasm

Wikipedia : 76 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), thyroid allostasis in critical illness,... more...

Related Diseases for Euthyroid Sick Syndrome

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism 29.7 DIO2 POMC SERPINA7
2 hyperthyroxinemia 10.2 ALB SERPINA7
3 graves disease 1 10.2 DIO2 SERPINA7
4 toxic diffuse goiter 10.1 DIO2 SERPINA7
5 subacute thyroiditis 10.1 IL6 SERPINA7
6 capillary leak syndrome 10.1 ALB IL6
7 hypersensitivity reaction type iii disease 10.1 ALB IL6
8 transient arthritis 10.1 ALB IL6
9 hemorrhagic fever 10.1 ALB IL6
10 prediabetes syndrome 10.1 ALB IL6
11 acute cystitis 10.1 ALB IL6
12 acute pyelonephritis 10.1 ALB IL6
13 protein-energy malnutrition 10.1 ALB IL6
14 meningoencephalitis 10.1 ALB IL6
15 hemorrhagic fever with renal syndrome 10.1 ALB IL6
16 intermittent claudication 10.1 ALB IL6
17 jejunoileitis 10.1 ALB IL1B
18 dengue hemorrhagic fever 10.1 ALB IL6
19 fascioliasis 10.1 ALB IL1B
20 conn's syndrome 10.1
21 coronary stenosis 10.1 ALB IL6
22 mastitis 10.1 ALB IL6
23 filariasis 10.1 ALB IL6
24 obstructive jaundice 10.1 ALB IL6
25 recurrent corneal erosion 10.1 IL1B IL6
26 bagassosis 10.1 IL1B IL6
27 paraneoplastic syndromes 10.1 IL1B IL6
28 periodontitis, chronic 10.1 IL1B IL6
29 uremic pruritus 10.1 IL1B IL6
30 glossitis 10.1 IL1B IL6
31 laryngitis 10.1 IL1B IL6
32 funisitis 10.1 IL1B IL6
33 acute vascular insufficiency of intestine 10.1 IL1B IL6
34 osteosclerotic myeloma 10.1 IL1B IL6
35 poems syndrome 10.1 IL1B IL6
36 periapical periodontitis 10.1 IL1B IL6
37 central nervous system vasculitis 10.1 IL1B IL6
38 stachybotrys chartarum 10.1 IL1B IL6
39 pleural disease 10.1 ALB IL1B
40 endometrial disease 10.1 IL1B IL6
41 vaginal disease 10.1 IL1B IL6
42 vaginitis 10.1 IL1B IL6
43 cysticercosis 10.1 IL1B IL6
44 hepatic encephalopathy 10.0 ALB IL6
45 eales disease 10.0 IL1B IL6
46 endometritis 10.0 IL1B IL6
47 gingival disease 10.0 IL1B IL6
48 pulpitis 10.0 IL1B IL6
49 joint disorders 10.0 IL1B IL6
50 middle ear disease 10.0 IL1B IL6

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to Euthyroid Sick Syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 ALB DIO1 DIO2 IL6 POMC
2 neoplasm MP:0002006 9.26 ALB IL1B IL6 POMC
3 renal/urinary system MP:0005367 9.02 ALB DIO1 DIO2 IL6 POMC

Drugs & Therapeutics for Euthyroid Sick Syndrome

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3 Anti-Ulcer Agents Phase 4
4 Gastrointestinal Agents Phase 4
5 Antacids Phase 4
6 Calcium, Dietary Phase 4
7 Antiviral Agents Phase 4
8 Expectorants Phase 4
9 Antioxidants Phase 4
10 Hormones Phase 4,Phase 2
11 N-monoacetylcystine Phase 4
12 Antidotes Phase 4
13 Anti-Infective Agents Phase 4
14 Free Radical Scavengers Phase 4
15 Respiratory System Agents Phase 4
16 Protective Agents Phase 4
17 Anesthetics Phase 3,Phase 2,Not Applicable
18 Central Nervous System Depressants Phase 3
19
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
20
Methylcobalamin Approved, Experimental, Investigational Not Applicable 13422-55-4
21
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
22
Cobalamin Experimental Not Applicable 13408-78-1 6438156
23 Hormones, Hormone Substitutes, and Hormone Antagonists
24 Hormone Antagonists
25 Vitamin B Complex Not Applicable
26 Vitamins Not Applicable
27 Vitamin B 12 Not Applicable
28 Vitamin B12 Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Levothyroxine for Children With Euthyroid Sick Syndrome Completed NCT01631305 Phase 4 Levothyroxine
2 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
3 Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02521168 Phase 3 Oral triiodothyronine;Placebo
4 Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02222532 Phase 3 Tetronine;Placebo
5 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
6 Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome Completed NCT03157466
7 Investigating the Role of EN in NTIS Among Fistula Patients Completed NCT02038504
8 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 Not Applicable liothyronine sodium;placebo
9 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
10 The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications Completed NCT01466023
11 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) Completed NCT01481402 Not Applicable Liothyronine;Liothyronine
12 Feeding the Critically Ill During Phases of Altered Redox Status Recruiting NCT03085615 Not Applicable
13 Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome Active, not recruiting NCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome

Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

MalaCards organs/tissues related to Euthyroid Sick Syndrome:

41
Thyroid, Pituitary, Heart, Bone, Brain, Liver, Lymph Node

Publications for Euthyroid Sick Syndrome

Articles related to Euthyroid Sick Syndrome:

(show top 50) (show all 73)
# Title Authors Year
1
Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome. ( 29894998 )
2018
2
Thyroid, Euthyroid Sick Syndrome ( 29489255 )
2018
3
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria. ( 29553046 )
2018
4
Relationship between disease severity and thyroid function in Chinese patients with euthyroid sick syndrome. ( 30075595 )
2018
5
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome. ( 30152254 )
2018
6
Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial. ( 30200092 )
2018
7
Euthyroid Sick Syndrome. ( 27065175 )
2016
8
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. ( 27737323 )
2016
9
Euthyroid sick syndrome in children with diabetic ketoacidosis. ( 25719594 )
2015
10
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. ( 25154407 )
2014
11
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. ( 23401683 )
2013
12
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. ( 21786251 )
2011
13
[Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. ( 19778808 )
2009
14
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? ( 18524495 )
2008
15
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. ( 19007679 )
2008
16
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. ( 17356583 )
2007
17
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. ( 16533439 )
2006
18
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. ( 16734083 )
2006
19
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. ( 16076941 )
2005
20
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? ( 15055468 )
2003
21
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. ( 25696169 )
2003
22
Euthyroid sick syndrome. ( 12005007 )
2002
23
Euthyroid sick syndrome in acute ischemic syndromes. ( 12463624 )
2002
24
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. ( 12030601 )
2002
25
Circulating IL-8 and IL-10 in euthyroid sick syndromes following bone marrow transplantation. ( 12482997 )
2002
26
Euthyroid sick syndrome in children with Hodgkin disease. ( 11293290 )
2001
27
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. ( 10930442 )
2000
28
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. ( 11138334 )
2000
29
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. ( 14564609 )
2000
30
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. ( 10913935 )
2000
31
Euthyroid sick syndrome. ( 17016284 )
2000
32
Euthyroid Sick Syndrome and the role of cytokines. ( 11704991 )
2000
33
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. ( 14600974 )
2000
34
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. ( 10660848 )
1999
35
Changes in metabolism of TRH in euthyroid sick syndrome. ( 10526245 )
1999
36
Trading one "dangerous dogma" for another? Thyroid hormone treatment of the "euthyroid sick syndrome". ( 10323414 )
1999
37
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. ( 10094108 )
1999
38
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. ( 9678522 )
1998
39
[Euthyroid sick syndrome: recent physiopathologic findings]. ( 9793151 )
1998
40
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. ( 9591009 )
1998
41
Euthyroid sick syndrome: an overview. ( 9086580 )
1997
42
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? ( 9024211 )
1997
43
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. ( 9086572 )
1997
44
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. ( 9349590 )
1997
45
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. ( 11862240 )
1996
46
Euthyroid sick syndrome in psychiatric inpatients. ( 8959294 )
1996
47
Nonthyroidal illness syndrome or euthyroid sick syndrome? ( 15251561 )
1996
48
Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. ( 8808092 )
1995
49
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? ( 7497757 )
1995
50
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. ( 7834406 )
1995

Variations for Euthyroid Sick Syndrome

Expression for Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for Euthyroid Sick Syndrome

GO Terms for Euthyroid Sick Syndrome

Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 ALB IL1B IL6 POMC SERPINA7
2 extracellular space GO:0005615 9.02 ALB IL1B IL6 POMC SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 IL1B IL6 POMC
2 response to glucocorticoid GO:0051384 9.48 IL1B IL6
3 positive regulation of T cell proliferation GO:0042102 9.46 IL1B IL6
4 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B IL6
5 negative regulation of neurogenesis GO:0050768 9.37 IL1B IL6
6 positive regulation of glial cell proliferation GO:0060252 9.32 IL1B IL6
7 hormone biosynthetic process GO:0042446 9.26 DIO1 DIO2
8 thyroid hormone generation GO:0006590 9.16 DIO1 DIO2
9 thyroid hormone metabolic process GO:0042403 8.96 DIO1 DIO2
10 positive regulation of neuroinflammatory response GO:0150078 8.62 IL1B IL6

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 selenium binding GO:0008430 8.96 DIO1 DIO2
2 thyroxine 5'-deiodinase activity GO:0004800 8.62 DIO1 DIO2

Sources for Euthyroid Sick Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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