MCID: ETH004
MIFTS: 42

Euthyroid Sick Syndrome

Categories: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

MalaCards integrated aliases for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 12 15 17
Euthyroid Sick Syndromes 56 45 74
Sick-Euthyroid Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2856
ICD9CM 36 790.94
MeSH 45 D005067
NCIt 51 C113170
ICD10 34 E07.81
UMLS 74 C0015190

Summaries for Euthyroid Sick Syndrome

MalaCards based summary : Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to hypothyroidism and hyperthyroxinemia. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Lung fibrosis and Photodynamic therapy-induced NF-kB survival signaling. The drugs Magnesium oxide and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and bone, and related phenotypes are endocrine/exocrine gland and neoplasm

Wikipedia : 77 Euthyroid sick syndrome (ESS) is a state of adaptation or dysregulation of thyrotropic feedback control... more...

Related Diseases for Euthyroid Sick Syndrome

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism 29.6 DIO2 POMC SERPINA7
2 hyperthyroxinemia 10.3 ALB SERPINA7
3 graves disease 1 10.2 DIO2 SERPINA7
4 toxic diffuse goiter 10.2 DIO2 SERPINA7
5 rere-related disorders 10.2
6 subacute thyroiditis 10.2 IL6 SERPINA7
7 capillary leak syndrome 10.2 ALB IL6
8 hypersensitivity reaction type iii disease 10.2 ALB IL6
9 transient arthritis 10.2 ALB IL6
10 prediabetes syndrome 10.2 ALB IL6
11 acute cystitis 10.2 ALB IL6
12 acute pyelonephritis 10.2 ALB IL6
13 protein-energy malnutrition 10.2 ALB IL6
14 meningoencephalitis 10.1 ALB IL6
15 hemorrhagic fever with renal syndrome 10.1 ALB IL6
16 burns 10.1 ALB IL1B
17 intermittent claudication 10.1 ALB IL6
18 dengue hemorrhagic fever 10.1 ALB IL6
19 jejunoileitis 10.1 ALB IL1B
20 fascioliasis 10.1 ALB IL1B
21 coronary stenosis 10.1 ALB IL6
22 mastitis 10.1 ALB IL6
23 filariasis 10.1 ALB IL6
24 obstructive jaundice 10.1 ALB IL6
25 recurrent corneal erosion 10.1 IL1B IL6
26 bagassosis 10.1 IL1B IL6
27 periodontitis, chronic 10.1 IL1B IL6
28 uremic pruritus 10.1 IL1B IL6
29 glossitis 10.1 IL1B IL6
30 laryngitis 10.1 IL1B IL6
31 funisitis 10.1 IL1B IL6
32 acute vascular insufficiency of intestine 10.1 IL1B IL6
33 ascaris lumbricoides infection 10.1 IL1B IL6
34 osteosclerotic myeloma 10.1 IL1B IL6
35 poems syndrome 10.1 IL1B IL6
36 periapical periodontitis 10.1 IL1B IL6
37 autoimmune gastritis 10.1 IL1B IL6
38 central nervous system vasculitis 10.1 IL1B IL6
39 pleural disease 10.1 ALB IL1B
40 stachybotrys chartarum 10.1 IL1B IL6
41 hepatic encephalopathy 10.1 ALB IL6
42 endometrial disease 10.1 IL1B IL6
43 vaginal disease 10.1 IL1B IL6
44 vaginitis 10.1 IL1B IL6
45 cysticercosis 10.1 IL1B IL6
46 eales disease 10.1 IL1B IL6
47 conn's syndrome 10.1
48 goiter 10.1
49 endometritis 10.1 IL1B IL6
50 gingival disease 10.1 IL1B IL6

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to Euthyroid Sick Syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 ALB DIO1 DIO2 IL6 POMC
2 neoplasm MP:0002006 9.26 ALB IL1B IL6 POMC
3 renal/urinary system MP:0005367 9.02 ALB DIO1 DIO2 IL6 POMC

Drugs & Therapeutics for Euthyroid Sick Syndrome

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Hormones Phase 4,Phase 2
5 Gastrointestinal Agents Phase 4
6 Antacids Phase 4
7 Anti-Ulcer Agents Phase 4
8 Calcium, Dietary Phase 4
9 Free Radical Scavengers Phase 4
10 Antidotes Phase 4
11 Expectorants Phase 4
12 Respiratory System Agents Phase 4
13 Antiviral Agents Phase 4
14 Anti-Infective Agents Phase 4
15 Protective Agents Phase 4
16 Antioxidants Phase 4
17 N-monoacetylcystine Phase 4
18 Anesthetics Phase 3,Phase 2,Not Applicable
19 Central Nervous System Depressants Phase 3
20
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
21
Methylcobalamin Approved, Experimental, Investigational Not Applicable 13422-55-4
22
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
23
Cobalamin Experimental Not Applicable 13408-78-1 6857388
24 Hormone Antagonists
25 Hormones, Hormone Substitutes, and Hormone Antagonists
26 Vitamin B12 Not Applicable
27 Vitamin B Complex Not Applicable
28 Vitamins Not Applicable
29 Vitamin B 12 Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Levothyroxine for Children With Euthyroid Sick Syndrome Completed NCT01631305 Phase 4 Levothyroxine
2 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
3 Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02521168 Phase 3 Oral triiodothyronine;Placebo
4 Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02222532 Phase 3 Tetronine;Placebo
5 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
6 Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome Completed NCT03157466
7 Investigating the Role of EN in NTIS Among Fistula Patients Completed NCT02038504
8 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 Not Applicable liothyronine sodium;placebo
9 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
10 Feeding the Critically Ill During Phases of Altered Redox Status Completed NCT03085615 Not Applicable
11 The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications Completed NCT01466023
12 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) Completed NCT01481402 Not Applicable Liothyronine;Liothyronine
13 Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome Active, not recruiting NCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome

Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

MalaCards organs/tissues related to Euthyroid Sick Syndrome:

42
Thyroid, Heart, Bone, Placenta, Pituitary, Bone Marrow, Lymph Node

Publications for Euthyroid Sick Syndrome

Articles related to Euthyroid Sick Syndrome:

(show top 50) (show all 75)
# Title Authors Year
1
Thyroid Hormone Profile in Children with Sepsis: Does Euthyroid Sick Syndrome Exist? ( 31049090 )
2019
2
Predictors for euthyroid sick syndrome and its impact on in-hospital clinical outcomes in high-risk patients undergoing coronary artery bypass grafting. ( 31074318 )
2019
3
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria ( 29553046 )
2018
4
Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome. ( 29894998 )
2018
5
Relationship between disease severity and thyroid function in Chinese patients with euthyroid sick syndrome. ( 30075595 )
2018
6
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome. ( 30152254 )
2018
7
Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial. ( 30200092 )
2018
8
Euthyroid Sick Syndrome. ( 27065175 )
2016
9
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. ( 27737323 )
2016
10
Euthyroid sick syndrome in children with diabetic ketoacidosis. ( 25719594 )
2015
11
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. ( 25154407 )
2014
12
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. ( 23401683 )
2013
13
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. ( 21786251 )
2011
14
[Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. ( 19778808 )
2009
15
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? ( 18524495 )
2008
16
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. ( 19007679 )
2008
17
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. ( 17356583 )
2007
18
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. ( 16533439 )
2006
19
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. ( 16734083 )
2006
20
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. ( 16076941 )
2005
21
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? ( 15055468 )
2003
22
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. ( 25696169 )
2003
23
Euthyroid sick syndrome. ( 12005007 )
2002
24
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. ( 12030601 )
2002
25
Euthyroid sick syndrome in acute ischemic syndromes. ( 12463624 )
2002
26
Circulating IL-8 and IL-10 in euthyroid sick syndromes following bone marrow transplantation. ( 12482997 )
2002
27
Euthyroid sick syndrome in children with Hodgkin disease. ( 11293290 )
2001
28
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. ( 10913935 )
2000
29
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. ( 10930442 )
2000
30
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. ( 11138334 )
2000
31
Euthyroid Sick Syndrome and the role of cytokines. ( 11704991 )
2000
32
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. ( 14564609 )
2000
33
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. ( 14600974 )
2000
34
Euthyroid sick syndrome. ( 17016284 )
2000
35
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. ( 10094108 )
1999
36
Trading one "dangerous dogma" for another? Thyroid hormone treatment of the "euthyroid sick syndrome". ( 10323414 )
1999
37
Changes in metabolism of TRH in euthyroid sick syndrome. ( 10526245 )
1999
38
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. ( 10660848 )
1999
39
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. ( 9591009 )
1998
40
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. ( 9678522 )
1998
41
[Euthyroid sick syndrome: recent physiopathologic findings]. ( 9793151 )
1998
42
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? ( 9024211 )
1997
43
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. ( 9086572 )
1997
44
Euthyroid sick syndrome: an overview. ( 9086580 )
1997
45
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. ( 9349590 )
1997
46
Leptin levels are elevated despite low thyroid hormone levels in the "euthyroid sick" syndrome. ( 9398759 )
1997
47
Euthyroid sick syndrome in psychiatric inpatients. ( 8959294 )
1996
48
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. ( 11862240 )
1996
49
Nonthyroidal illness syndrome or euthyroid sick syndrome? ( 15251561 )
1996
50
Euthyroid sick syndrome in pulmonary tuberculosis before and after treatment. ( 7486798 )
1995

Variations for Euthyroid Sick Syndrome

Expression for Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for Euthyroid Sick Syndrome

GO Terms for Euthyroid Sick Syndrome

Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 ALB IL1B IL6 POMC SERPINA7
2 extracellular space GO:0005615 9.02 ALB IL1B IL6 POMC SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 IL1B IL6 POMC
2 positive regulation of T cell proliferation GO:0042102 9.46 IL1B IL6
3 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B IL6
4 negative regulation of neurogenesis GO:0050768 9.37 IL1B IL6
5 positive regulation of glial cell proliferation GO:0060252 9.32 IL1B IL6
6 hormone biosynthetic process GO:0042446 9.26 DIO1 DIO2
7 response to glucocorticoid GO:0051384 9.18 IL6
8 thyroid hormone generation GO:0006590 9.16 DIO1 DIO2
9 thyroid hormone metabolic process GO:0042403 8.96 DIO1 DIO2
10 positive regulation of neuroinflammatory response GO:0150078 8.62 IL1B IL6

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 selenium binding GO:0008430 8.96 DIO1 DIO2
2 thyroxine 5'-deiodinase activity GO:0004800 8.62 DIO1 DIO2

Sources for Euthyroid Sick Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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