MCID: ETH004
MIFTS: 41

Euthyroid Sick Syndrome

Categories: Endocrine diseases
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Aliases & Classifications for Euthyroid Sick Syndrome

MalaCards integrated aliases for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 11 14 16 75
Euthyroid Sick Syndromes 53 43 71
Sick-Euthyroid Syndrome 11 33
Tscitus - [thyroid Allostasis in Critical Illness, Tumours, Uraemia and Starvation] 33
Ntis - [non-Thyroidal Illness Syndrome] 33
Ess - [euthyroid Sick Syndrome] 33
Low-T3 Syndrome 33

Classifications:



External Ids:

Disease Ontology 11 DOID:2856
ICD9CM 34 790.94
MeSH 43 D005067
NCIt 49 C113170
SNOMED-CT 68 237542005
ICD11 33 998433478
UMLS 71 C0015190

Summaries for Euthyroid Sick Syndrome

MalaCards based summary: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to chronic kidney disease and acute myocarditis. An important gene associated with Euthyroid Sick Syndrome is SERPINA7 (Serpin Family A Member 7), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Thyroid hormones production and peripheral downstream signaling effects. The drugs Magnesium oxide and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, hypothalamus and pituitary, and related phenotypes are renal/urinary system and homeostasis/metabolism

Wikipedia: 75 Euthyroid sick syndrome (ESS) is a state of adaptation or dysregulation of thyrotropic feedback control... more...

Related Diseases for Euthyroid Sick Syndrome

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 399)
# Related Disease Score Top Affiliating Genes
1 chronic kidney disease 30.3 NPPB IL6 IL1B ALB
2 acute myocarditis 30.3 NPPB IL6 IL1B
3 intermediate coronary syndrome 30.3 NPPB IL6 ALB
4 pulmonary tuberculosis 30.3 IL6 IL1B ALB
5 exanthem 30.2 IL6 IL1B ALB
6 myocarditis 30.2 NPPB IL6 IL1B ALB
7 respiratory failure 30.2 NPPB IL6 IL1B ALB
8 pituitary-dependent cushing's disease 30.2 TRH POMC
9 peripheral vascular disease 30.2 IL6 IL1B ALB
10 hypothalamic disease 30.2 TRH POMC
11 rheumatic fever 30.1 NPPB IL6 ALB
12 viral hepatitis 30.1 TG IL6 ALB
13 severe covid-19 30.1 IL6 IL1B ALB
14 hypopituitarism 30.0 TRH POMC IL6
15 congestive heart failure 30.0 NPPB IL6 IL1B ALB
16 goiter 30.0 TRH TG SERPINA7 IL6
17 chronic fatigue syndrome 29.9 POMC IL6 IL1B
18 substance abuse 29.9 POMC IL6 IL1B ALB
19 leptin deficiency or dysfunction 29.8 TRH POMC IL6 IL1B
20 conn's syndrome 29.8 TRH POMC IL6 ALB
21 stroke, ischemic 29.8 NPPB IL6 IL1B ALB
22 lipid metabolism disorder 29.7 POMC IL6 IL1B ALB
23 hypothyroidism 29.4 TRH TG SERPINA7 POMC NPPB DIO3
24 hyperthyroidism 29.1 TRH TG SLC16A2 SERPINA7 POMC IL6
25 diabetes mellitus 29.0 TG POMC NPPB IL6 IL1B DIO2
26 type 2 diabetes mellitus 29.0 POMC NPPB IL6 IL1B DIO2 ALB
27 graves disease 1 28.7 TRH TG SLC16A2 SERPINA7 POMC DIO3
28 hypothyroidism, congenital, nongoitrous, 1 10.6
29 hypothyroidism, congenital, nongoitrous, 2 10.6
30 hypothyroidism, congenital, nongoitrous, 3 10.6
31 critical illness polyneuropathy 10.3 IL6 ALB
32 wild-type amyloidosis 10.3 SERPINA7 NPPB
33 acute thyroiditis 10.3 TG SERPINA7
34 non-syndromic x-linked intellectual disability 96 10.3 IL1B ALB
35 hydrops of gallbladder 10.3 NPPB ALB
36 mediastinitis 10.3 IL6 ALB
37 aspiration pneumonitis 10.3 IL6 ALB
38 generalized atherosclerosis 10.3 IL6 ALB
39 acute cholangitis 10.3 IL6 ALB
40 periodontitis, chronic 10.3 IL6 IL1B
41 osteosclerotic myeloma 10.3 IL6 IL1B
42 acute pericementitis 10.3 IL6 IL1B
43 paralytic ileus 10.3 IL6 ALB
44 indolent plasma cell myeloma 10.3 IL6 IL1B
45 angular cheilitis 10.3 IL6 ALB
46 pericoronitis 10.3 IL6 IL1B
47 transient arthritis 10.3 IL6 IL1B
48 necrotizing ulcerative gingivitis 10.3 IL6 IL1B
49 chronic apical periodontitis 10.3 IL6 IL1B
50 intracranial embolism 10.3 IL6 ALB

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to Euthyroid Sick Syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.5 ALB DIO1 DIO2 IL6 POMC SLC16A10
2 homeostasis/metabolism MP:0005376 9.36 ALB DIO1 DIO2 DIO3 IL1B IL6

Drugs & Therapeutics for Euthyroid Sick Syndrome

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
3 Anti-Ulcer Agents Phase 4
4 Antacids Phase 4
5 Calcium, Dietary Phase 4
6 Gastrointestinal Agents Phase 4
7 Antiviral Agents Phase 4
8 Anti-Infective Agents Phase 4
9 Expectorants Phase 4
10 Antidotes Phase 4
11 N-monoacetylcystine Phase 4
12 Respiratory System Agents Phase 4
13 Antioxidants Phase 4
14 Protective Agents Phase 4
15
Calcium Nutraceutical Phase 4 7440-70-2 271
16 Anesthetics Phase 2
17 Hormones Phase 2
18
Mecobalamin Approved, Investigational 13422-55-4
19
Hydroxocobalamin Approved 13422-51-0 15589840 44475014
20
Cyanocobalamin Approved, Nutraceutical 68-19-9 24892734 16212801 44176380
21
Cobalamin Experimental 13408-78-1 6857388
22 Vitamins
23 Vitamin B12
24 Vitamin B Complex
25 Vitamin B 12

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Levothyroxine in Critical Children With Euthyroid Sick Syndrome in a Pediatric Intensive Care Unit. Completed NCT01631305 Phase 4 Levothyroxine
2 Evaluation of the Effects of N-acetylcysteine on Thyroid Hormone Levels in the Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
3 Oral Triiodothyronine Normalizes T3 Levels After Surgery For Pediatric Congenital Heart Disease Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
4 Triiodothyronine Hormone Replacement Therapy in Patients With Septic Shock With Euthyroid Sick Syndrome Recruiting NCT05270798 Phase 2 triiodothyronine
5 Development of Rational and Standardized Diagnostics and Staging for a Differentiated Risk Stratification of Non-thyroidal Illness Syndrome Unknown status NCT00591032
6 Feeding the Critically Ill During Phases of Altered Redox Status (FEDOX): a Prospective Randomized Trial Completed NCT03085615
7 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
8 Diaphragmatic Efficiency After Thyroid Hormone Replacement Therapy in Ventilated Patients With the Nonthyroidal Illness Syndrome: a Physiological Study Completed NCT03157466
9 Nonthyroidal Illness Syndrome in Patients With Short Bowel Syndrome Completed NCT04450472
10 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Heart Function, Body Composition and Metabolic Status Completed NCT01481402 Liothyronine
11 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 liothyronine sodium;placebo
12 Euthyroid Sick Syndrome (ESS)….. Can it Influence Morbidity and Mortality in Moderate to Severe Traumatic Brain Injury Patients or Correlate With Glial Fibrillary Acidic Protein (GFAP) Level. Not yet recruiting NCT04806672

Search NIH Clinical Center for Euthyroid Sick Syndrome

Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

Organs/tissues related to Euthyroid Sick Syndrome:

MalaCards : Thyroid, Hypothalamus, Pituitary, Heart, Brain, Bone Marrow, Liver

Publications for Euthyroid Sick Syndrome

Articles related to Euthyroid Sick Syndrome:

(show top 50) (show all 738)
# Title Authors PMID Year
1
Relating circulating thyroid hormone concentrations to serum interleukins-6 and -10 in association with non-thyroidal illnesses including chronic renal insufficiency. 53 62
18211669 2008
2
Relationship between circulating cytokine levels and thyroid function following bone marrow transplantation. 53 62
14704661 2004
3
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues. 53 62
14635503 2003
4
[Involvement of thyroid hormones in mental recovery following severe craniocerebral trauma]. 53 62
11544736 2001
5
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. 53 62
10913935 2000
6
[Studies on circulating interleukin-6 and thyroid functions in acute myocardial infarction]. 53 62
10804837 2000
7
Administration of interferon-gamma in healthy subjects does not modulate thyroid hormone metabolism. 53 62
10691318 2000
8
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. 53 62
10094108 1999
9
Modulation of chronic excessive interleukin-6 production in multiple myeloma does not affect thyroid hormone concentrations. 53 62
9361697 1997
10
Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome. 53 62
8940342 1996
11
Interleukin-6 (IL-6) inhibits thyroid function in the presence of soluble IL-6 receptor in cultured human thyroid follicles. 53 62
8895357 1996
12
Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans. 53 62
7962327 1994
13
The relationship between serum levels of interleukin-6 and thyroid hormone in children with acute respiratory infection. 53 62
8106613 1994
14
Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus. 62
36089765 2022
15
Correlation between Neutrophil-to-lymphocyte ratio and Euthyroid Sick Syndrome in elderly patients with proximal femur fractures. 62
36448864 2022
16
Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis. 62
36447149 2022
17
Low triiodothyronine syndrome is associated with stroke-associated pneumonia. 62
35842892 2022
18
Biochemical indicators of euthyroid sick syndrome in critically ill children. 62
36106490 2022
19
Thyroid hormones and platelet activation in COVID-19 patients. 62
36064879 2022
20
Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure-Preliminary In Vivo Study. 62
36136476 2022
21
Thyroid Hormones and Health-Related Quality of Life in Normal Pressure Hydrocephalus Patients before and after the Ventriculoperitoneal Shunt Surgery: A Longitudinal Study. 62
35956055 2022
22
Low T3 syndrome is associated with poor prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure. 62
35723536 2022
23
Effect of perioperative use of oral triidothyronine for infants undergoing complex congenital cardiac surgeries under cardiopulmonary bypass: A double-blinded randomised controlled study. 62
35799553 2022
24
Euthyroid Sick Syndrome as a Prognostic Indicator of COVID-19 Pulmonary Involvement, Associated With Poorer Disease Prognosis and Increased Mortality. 62
35202790 2022
25
Letter to the Editor: 'Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS‑CoV‑2 disease'-prognostic significance of non-thyroidal illness syndrome across the whole spectrum of COVID-19 severity. 62
35023079 2022
26
Low testosterone predicts hypoxemic respiratory insufficiency and mortality in patients with COVID-19 disease: another piece in the COVID puzzle. 62
34792796 2022
27
Covid-19, the thyroid and the pituitary - The real state of play. 62
35065920 2022
28
Response to Letter to the Editor from Lui et al.: 'Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease': prognostic significance of non-thyroidal illness syndrome in the whole spectrum of COVID-19 severity. 62
35088382 2022
29
Study of Sick Euthyroid Syndrome in Organophosphate Poisoning. 62
35443547 2022
30
Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease. 62
34850365 2022
31
Endocrine Follow-up During Post-Acute COVID-19: Practical Recommendations Based on Available Clinical Evidence. 62
35158058 2022
32
To Study the Association between Sick Euthyroid State and the Incidence of ACS. 62
35443333 2022
33
The Role of Thyroid Hormones on Skeletal Muscle Thermogenesis. 62
35448523 2022
34
Low T3 syndrome as a prognostic factor in patients in the intensive care unit: an observational cohort study. 62
35946657 2022
35
Potential relationships between COVID-19 and the thyroid gland: an update. 62
35226548 2022
36
Thyroid Function and Low Free Triiodothyronine in Chinese Patients With Autoimmune Encephalitis. 62
35222399 2022
37
The Association Between FT3 With the Outcome and Inflammation/Coagulopathy/Fibrinolysis of COVID-19. 62
35721727 2022
38
The Association Between Low T3 Syndrome and Survival in Patients With Newly Diagnosed Multiple Myeloma: A Retrospective Study. 62
35443837 2022
39
Prevalence of Thyroid Dysfunction Among Patients with Heart Failure at a Tertiary Hospital in Mogadishu, Somalia. 62
35924177 2022
40
Low Triiodothyronine Syndrome Increased the Incidence of Acute Kidney Injury After Cardiac Surgery. 62
35115813 2022
41
PECULIARITIES OF THYROID STATUS OF PRESCHOOL CHILDREN WITH ACUTE BRONCHITIS. 62
35633358 2022
42
Correlation and Prognostic Assessment of Low T3 Syndrome and Norepinephrine Dosage for Patients with Sepsis: A Retrospective Single-Center (Cohort) Study. 62
35585999 2022
43
Thyroid diseases are associated with coronavirus disease 2019 infection. 62
36120425 2022
44
Effect of hypothyroidism on contractile performance of isolated end-stage failing human myocardium. 62
35404981 2022
45
Frequency of Euthyroid Sick Syndrome before and after renal transplantation in patients with end stage renal disease and its association with oxidative stress. 62
34649484 2022
46
Evaluation of the Thyroid Characteristics and Correlated Factors in Hospitalized Patients with Newly Diagnosed Type 2 Diabetes. 62
35340987 2022
47
Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study. 62
35600708 2022
48
Thyroid dysfunction in COVID-19 patients. 62
34101132 2021
49
An analysis of perinatal factors of low T3 syndrome in preterm neonates with a gestational age of 28-35 weeks. 62
34596490 2021
50
The Prevalence and Pattern of Thyroid Dysfunction in HAART-Naïve HIV Patients in Enugu, Nigeria: A Cross-Sectional Comparative Study. 62
35037450 2021

Variations for Euthyroid Sick Syndrome

Expression for Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for Euthyroid Sick Syndrome

GO Terms for Euthyroid Sick Syndrome

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone biosynthetic process GO:0042446 9.76 DIO1 DIO2 DIO3 TG
2 positive regulation of neuroinflammatory response GO:0150078 9.73 IL6 IL1B
3 thyroid hormone transport GO:0070327 9.73 SLC16A2 SLC16A10 SERPINA7
4 vascular endothelial growth factor production GO:0010573 9.71 IL6 IL1B
5 thyroid-stimulating hormone secretion GO:0070460 9.67 SLC16A2 SLC16A10
6 thyroid hormone generation GO:0006590 9.65 TG SLC16A2 SLC16A10 DIO2 DIO1
7 thyroid hormone catabolic process GO:0042404 9.62 DIO3 DIO2
8 thyroid hormone metabolic process GO:0042403 9.28 TG SLC16A2 DIO3 DIO2 DIO1

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.7 TRH TG POMC NPPB
2 selenium binding GO:0008430 9.62 DIO2 DIO1
3 thyroid hormone transmembrane transporter activity GO:0015349 9.56 SLC16A2 SLC16A10
4 thyroxine 5-deiodinase activity GO:0033798 9.26 DIO3 DIO2
5 thyroxine 5'-deiodinase activity GO:0004800 9.1 DIO3 DIO2 DIO1

Sources for Euthyroid Sick Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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