MCID: ETH004
MIFTS: 37

Euthyroid Sick Syndrome

Categories: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

MalaCards integrated aliases for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 12 15 17
Euthyroid Sick Syndromes 54 43 71
Sick-Euthyroid Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2856
ICD9CM 34 790.94
MeSH 43 D005067
NCIt 49 C113170
ICD10 32 E07.81
UMLS 71 C0015190

Summaries for Euthyroid Sick Syndrome

MalaCards based summary : Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to cardiogenic shock and congestive heart failure. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Folate Metabolism. The drugs Magnesium oxide and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and heart, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 74 Euthyroid sick syndrome (ESS) is a state of adaptation or dysregulation of thyrotropic feedback control... more...

Related Diseases for Euthyroid Sick Syndrome

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 30.5 NPPB IL6
2 congestive heart failure 30.2 NPPB IL6 ALB
3 pituitary-dependent cushing's disease 30.0 TRH POMC
4 hypothalamic disease 29.9 TRH POMC
5 lung disease 29.6 NPPB IL6 IL1B ALB
6 goiter 29.5 TRH TG SERPINA7
7 respiratory failure 29.5 SERPINA7 NPPB IL6 IL1B ALB
8 hyperthyroidism 29.1 TRH TG SERPINA7 POMC ALB
9 hypothyroidism 28.0 TRH THRSP TG SERPINA7 POMC DIO2
10 graves disease 1 27.5 TRH THRSP TG SERPINA7 POMC DIO2
11 generalized atherosclerosis 10.4 IL6 ALB
12 acute cholangitis 10.4 IL6 ALB
13 prosthetic joint infection 10.4 IL6 IL1B
14 osteosclerotic myeloma 10.4 IL6 IL1B
15 periodontitis, chronic 10.4 IL6 IL1B
16 uremic pruritus 10.3 IL6 IL1B
17 pyuria 10.3 IL6 ALB
18 lung abscess 10.3 IL6 ALB
19 corticosteroid-binding globulin deficiency 10.3 SERPINA7 POMC
20 acute adrenal insufficiency 10.3 POMC IL6
21 subacute glomerulonephritis 10.3 POMC ALB
22 indolent myeloma 10.3 IL6 IL1B
23 stachybotrys chartarum 10.3 IL6 IL1B
24 eales disease 10.3 IL6 IL1B
25 background diabetic retinopathy 10.3 IL6 ALB
26 recurrent corneal erosion 10.3 IL6 IL1B
27 cardiomyopathy, familial hypertrophic, 20 10.3 IL6 ALB
28 irritant dermatitis 10.3 IL6 IL1B
29 idiopathic neutropenia 10.3 IL6 IL1B
30 hantavirus hemorrhagic fever with renal syndrome 10.3 IL6 ALB
31 benign essential hypertension 10.3 POMC ALB
32 periapical periodontitis 10.3 IL6 IL1B
33 dental pulp disease 10.3 IL6 IL1B
34 laryngitis 10.3 IL6 IL1B
35 cranial nerve palsy 10.3 POMC ALB
36 thyroid crisis 10.3 TG SERPINA7
37 intestinal perforation 10.3 IL6 ALB
38 bagassosis 10.3 IL6 IL1B
39 iodine hypothyroidism 10.3 TG ALB
40 hypersensitivity reaction type iii disease 10.3 IL6 ALB
41 blood group, globoside system 10.3 IL6 ALB
42 glossitis 10.3 IL6 IL1B
43 polycystic kidney disease 4 10.3 NPPB ALB
44 endemic goiter 10.2 TG SERPINA7
45 clostridium difficile colitis 10.2 IL1B ALB
46 hypothyroidism, congenital, nongoitrous, 2 10.2 TG SERPINA7
47 decubitus ulcer 10.2 IL6 ALB
48 polyradiculopathy 10.2 IL6 IL1B
49 thyrotoxic exophthalmos 10.2 TG IL6
50 nontoxic goiter 10.2 TG SERPINA7

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to Euthyroid Sick Syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 ALB DIO1 DIO2 IL6 POMC TG
2 digestive/alimentary MP:0005381 9.73 ALB DIO1 DIO2 IL6 TG TRH
3 homeostasis/metabolism MP:0005376 9.61 ALB DIO1 DIO2 IL1B IL6 POMC
4 renal/urinary system MP:0005367 9.1 ALB DIO1 DIO2 IL6 POMC TRH

Drugs & Therapeutics for Euthyroid Sick Syndrome

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Gastrointestinal Agents Phase 4
5 Anti-Ulcer Agents Phase 4
6 Hormones Phase 4
7 Calcium, Dietary Phase 4
8 Antacids Phase 4
9 Anti-Infective Agents Phase 4
10 Respiratory System Agents Phase 4
11 N-monoacetylcystine Phase 4
12 Free Radical Scavengers Phase 4
13 Antioxidants Phase 4
14 Antiviral Agents Phase 4
15 Protective Agents Phase 4
16 Antidotes Phase 4
17 Expectorants Phase 4
18 Anesthetics Phase 3
19 Central Nervous System Depressants Phase 3
20 Hormone Antagonists Phase 2
21
Methylcobalamin Approved, Investigational 13422-55-4
22
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
23
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
24
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
25
Cobalamin Experimental 13408-78-1 6857388
26 Vitamins
27 Micronutrients
28 Vitamin B 12
29 Trace Elements
30 Vitamin B Complex
31 Vitamin B9
32 Nutrients
33 Vitamin B12
34 Folate

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Levothyroxine in Critical Children With Euthyroid Sick Syndrome in a Pediatric Intensive Care Unit. Completed NCT01631305 Phase 4 Levothyroxine
2 Evaluation of the Effects of N-acetylcysteine on Thyroid Hormone Levels in the Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
3 Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02521168 Phase 3 Oral triiodothyronine;Placebo
4 Tetronine (Sodium Liothyronine) for Infants & Children Undergoing Cardiopulmonary Bypass in a Middle Income Nation (OTICC Study) Completed NCT02222532 Phase 3 Tetronine;Placebo
5 Oral Triiodothyronine Normalizes T3 Levels After Surgery For Pediatric Congenital Heart Disease Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
6 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 liothyronine sodium;placebo
7 Diaphragmatic Efficiency After Thyroid Hormone Replacement Therapy in Ventilated Patients With the Nonthyroidal Illness Syndrome: a Physiological Study Completed NCT03157466
8 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Heart Function, Body Composition and Metabolic Status Completed NCT01481402 Liothyronine;Liothyronine
9 Feeding the Critically Ill During Phases of Altered Redox Status (FEDOX): a Prospective Randomized Trial Completed NCT03085615
10 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
11 Interrelations Between FT3, FT4 and Pituitary TSH and Implications For Thyroid Hormone Treatment (IIFHT-Study) Completed NCT01969552
12 Development of Rational and Standardized Diagnostics and Staging for a Differentiated Risk Stratification of Non-thyroidal Illness Syndrome Active, not recruiting NCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome

Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

MalaCards organs/tissues related to Euthyroid Sick Syndrome:

40
Thyroid, Pituitary, Heart, Kidney, Lung, Testes, Bone

Publications for Euthyroid Sick Syndrome

Articles related to Euthyroid Sick Syndrome:

(show top 50) (show all 261)
# Title Authors PMID Year
1
Relating circulating thyroid hormone concentrations to serum interleukins-6 and -10 in association with non-thyroidal illnesses including chronic renal insufficiency. 54 61
18211669 2008
2
Relationship between circulating cytokine levels and thyroid function following bone marrow transplantation. 54 61
14704661 2004
3
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues. 54 61
14635503 2003
4
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. 54 61
10913935 2000
5
[Studies on circulating interleukin-6 and thyroid functions in acute myocardial infarction]. 54 61
10804837 2000
6
Administration of interferon-gamma in healthy subjects does not modulate thyroid hormone metabolism. 54 61
10691318 2000
7
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. 54 61
10094108 1999
8
Modulation of chronic excessive interleukin-6 production in multiple myeloma does not affect thyroid hormone concentrations. 54 61
9361697 1997
9
Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans. 54 61
7962327 1994
10
The relationship between serum levels of interleukin-6 and thyroid hormone in children with acute respiratory infection. 54 61
8106613 1994
11
Euthyroid sick syndrome in hip fractures: Valuation of vitamin D and parathyroid hormone axis. 61
31983423 2020
12
Predictors for euthyroid sick syndrome and its impact on in-hospital clinical outcomes in high-risk patients undergoing coronary artery bypass grafting. 61
31074318 2019
13
Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease. 61
31651357 2019
14
Evaluation of Thyroid Function Tests in Children with Chronic Liver Diseases 61
31486329 2019
15
Thyroid Hormone Profile in Children with Sepsis: Does Euthyroid Sick Syndrome Exist? 61
31049090 2019
16
Prevalence and Pattern of Thyroid Disorders among Patients Attending University of Nigeria Teaching Hospital, Enugu, Southeastern Nigeria. 61
31462844 2019
17
Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria. 61
31015954 2019
18
Relationships of Chronic Kidney Disease and Thyroid Dysfunction in Non-Dialysis Patients: A Pilot Study. 61
31013508 2019
19
Thyroid dysfunction in children with leukemia over the first year after hematopoietic stem cell transplantation. 61
30325734 2018
20
Adequate restitution in primary hypothyroidism depending on levothyroxine formulations 61
30376277 2018
21
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome. 61
30152254 2018
22
Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial. 61
30200092 2018
23
Relationship between disease severity and thyroid function in Chinese patients with euthyroid sick syndrome. 61
30075595 2018
24
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria 61
29553046 2018
25
Prognostic Value of Thyroid Profile in Critical Care Condition. 61
30090732 2018
26
Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome. 61
29894998 2018
27
Impact of diabetic ketoacidosis on thyroid function tests in type 1 diabetes mellitus patients. 61
28034690 2017
28
Pattern of Thyroid Disorders in Children and Adolescents Seen at the Lagos University Teaching Hospital, Nigeria, Over a 10-year Period. 61
29962651 2017
29
Thyroid function and cardiovascular events in chronic kidney disease patients. 61
27039198 2017
30
[Euthyroid sick syndrome: an important clinical problem]. 61
29059662 2017
31
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. 61
27737323 2016
32
Thyroid Dysfunctions in a Sample of Egyptian Children and Adolescents with Systemic Lupus Erythematosus: Relation to Disease Activity and Duration. 61
28502134 2016
33
[Euthyroid sick syndrome as a risk factor for mortality in critically ill patients]. 61
26520613 2016
34
Euthyroid Sick Syndrome. 61
27065175 2016
35
Thyroid Hormone Profile in Patients With Acute Coronary Syndrome. 61
26421178 2015
36
Thyroid function status and its impact on clinical outcome in patients admitted to critical care. 61
26430429 2015
37
Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia. 61
25976636 2015
38
Euthyroid sick syndrome in children with diabetic ketoacidosis. 61
25719594 2015
39
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. 61
25154407 2014
40
Thyroid hormone and the stunned myocardium. 61
25128568 2014
41
Cardiac death risk in diabetic haemodialysis patients increased due to thyroid problems. 61
25337609 2014
42
Thyroid function, cardiovascular events, and mortality in diabetic hemodialysis patients. 61
24315768 2014
43
[Thyroid dysfunction in adults infected by human immunodeficiency virus]. 61
25188661 2014
44
[Comparison of the changes of thyroid hormones after video-assisted thoracoscopic surgery and conventional thoracotomy in patients with non-small cell lung cancer]. 61
24345490 2013
45
Prognostic impact of subclinical thyroid dysfunction in heart failure. 61
23041000 2013
46
Risk factors for short term thyroid dysfunction after hematopoietic stem cell transplantation in children. 61
23908670 2013
47
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. 61
23401683 2013
48
Thyroid function tests in acute kidney injury. 61
22419237 2013
49
Prevalence of thyroid dysfunction in untreated cancer patients: a cross-sectional study. 61
22729367 2012
50
Effects of hypothyroidism on the respiratory system and control of breathing: Human studies and animal models. 61
22394514 2012

Variations for Euthyroid Sick Syndrome

Expression for Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for Euthyroid Sick Syndrome

Pathways related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 POMC IL6 IL1B
2
Show member pathways
11.35 IL6 IL1B DIO2 DIO1 ALB
3 10.72 IL6 IL1B
4 9.73 TRH TG

GO Terms for Euthyroid Sick Syndrome

Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 SERPINA7 POMC NPPB IL6 IL1B ALB
2 extracellular region GO:0005576 9.23 TRH TG SERPINA7 POMC NPPB IL6
3 secretory granule GO:0030141 9.13 TRH POMC IL1B

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of vascular endothelial growth factor production GO:0010575 9.4 IL6 IL1B
2 negative regulation of neurogenesis GO:0050768 9.37 IL6 IL1B
3 positive regulation of glial cell proliferation GO:0060252 9.32 IL6 IL1B
4 thyroid hormone generation GO:0006590 9.26 DIO2 DIO1
5 positive regulation of neuroinflammatory response GO:0150078 9.16 IL6 IL1B
6 hormone biosynthetic process GO:0042446 9.13 TG DIO2 DIO1
7 thyroid hormone metabolic process GO:0042403 8.8 TG DIO2 DIO1

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 selenium binding GO:0008430 9.16 DIO2 DIO1
2 thyroxine 5'-deiodinase activity GO:0004800 8.96 DIO2 DIO1
3 hormone activity GO:0005179 8.92 TRH TG POMC NPPB

Sources for Euthyroid Sick Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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