ES
MCID: EWN003
MIFTS: 69

Ewing Sarcoma (ES)

Categories: Bone diseases, Cancer diseases, Genetic diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Ewing Sarcoma

MalaCards integrated aliases for Ewing Sarcoma:

Name: Ewing Sarcoma 56 12 52 25 73 36 13 15 17
Neuroepithelioma 56 74 52 54 71
Ewing's Sarcoma 74 52 25 29 6
Ewing's Tumor 12 52 25 73
Primitive Neuroectodermal Tumor 73 6 17
Peripheral Neuroepithelioma 58 73 54
Ewings Sarcoma 12 54 71
Askin Tumor 73 43 17
Localized Peripheral Primitive Neuroectodermal Tumor 12 71
Ewings Sarcoma-Primitive Neuroectodermal Tumor 12 71
Peripheral Primitive Neuroectodermal Tumor 12 58
Sarcoma, Ewing's 52 39
Ewing Tumor 52 25
Es 56 73
Localized Ewing's Sarcoma/peripheral Primitive Neuroectodermal Tumor 12
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor 71
Ewing's Sarcoma/peripheral Primitive Neuroectodermal Tumor 12
Neuroectodermal Tumors, Primitive, Peripheral 43
Neuroectodermal Tumor, Primitive 71
Pnet of Thoracopulmonary Region 12
Ewing's Family Localized Tumor 12
Ewing Sarcoma Family of Tumors 73
Neuroepithelioma, Peripheral 71
Localized Ewing's Sarcoma 12
Tumor of the Ewing Family 25
Extraosseous Ewing Tumor 73
Localized Ewing Sarcoma 12
Localized Ewing's Tumor 12
Ewing Family of Tumors 25
Skeletal Ewing Sarcoma 58
Pnet of the Chest Wall 73
Osseous Ewing Sarcoma 58
Peripheral Pnet 58
Disorder of Eye 71
Sarcoma, Ewing 43
Askin's Tumor 71
Ppnet 58
Pnet 73
Esft 73
Pne 73

Characteristics:

Orphanet epidemiological data:

58
skeletal ewing sarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Childhood;

HPO:

31
ewing sarcoma:
Inheritance somatic mutation


Classifications:

Orphanet: 58  
Rare bone diseases


Summaries for Ewing Sarcoma

Genetics Home Reference : 25 Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), and Askin tumor. These tumors are considered to be related because they have similar genetic causes. These types of Ewing sarcoma can be distinguished from one another by the tissue in which the tumor develops. Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. Extraosseous (or extraskeletal) Ewing sarcoma describes tumors in the soft tissues around bones, such as cartilage. pPNETs occur in nerve tissue and can be found in many parts of the body. A type of pPNET found in the chest is called Askin tumor. Ewing sarcomas most often occur in children and young adults. Affected individuals usually feel stiffness, pain, swelling, or tenderness of the bone or surrounding tissue. Sometimes, there is a lump near the surface of the skin that feels warm and soft to the touch. Often, children have a fever that does not go away. Ewing sarcoma of bone can cause weakening of the involved bone, and affected individuals may have a broken bone with no obvious cause. It is common for Ewing sarcoma to spread to other parts of the body (metastasize), usually to the lungs, to other bones, or to the bone marrow.

MalaCards based summary : Ewing Sarcoma, also known as neuroepithelioma, is related to extraosseous ewing sarcoma and ewing sarcoma of bone, and has symptoms including fever, visual disturbance and eye manifestations. An important gene associated with Ewing Sarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and lung, and related phenotypes are peripheral primitive neuroectodermal neoplasm and weight loss

Disease Ontology : 12 A bone sarcoma that has material basis in neural crest cells derives from undeveloped, undifferentiated neuroectoderm.

NIH Rare Diseases : 52 Ewing sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis ) to the lungs and other bones. The cause of Ewing sarcoma is unknown. Most cases are thought to occur randomly and many involved a reciprocal translocation between chromosomes 11 and 22. Treatment depends upon a number of factors, but may include chemotherapy , radiation and/or surgical interventions.

OMIM : 56 The Ewing sarcoma family of tumors (primitive neuroectodermal tumors; PNET) comprise morphologically heterogeneous tumors that are characterized by nonrandom chromosomal translocations involving the EWS gene on chromosome 22q12 and one of several members of the ETS family of transcription factors. The tumors include Ewing sarcoma, peripheral neuroepithelioma, and Askin tumor. In approximately 90% of cases of ESFT, the FLI1 gene (193067) on chromosome 11 is the fusion partner of EWS; in approximately 10%, the EWS fusion partner is the ERG gene (165080) on chromosome 22. Many other ETS family members have been identified as fusion partners of EWS, but these cases are rare (Khoury, 2005). (612219)

KEGG : 36 Ewing sarcoma is the second most common malignant bone tumor occurring in children and young adults, and accounts for 10-15% of all primary bone tumors. The annual incidence is approximately 0.6/million total population, and it usually occurs between the ages of 10 and 20 years. Ewing's sarcoma is in 85% of cases associated with the translocation t(11;22)(q24;q12), which leads to the formation of the EWSR1-FLI1 fusion gene. In another 10-15% of cases the translocation t(21;12)(22;12) generates the EWSR1-ERG fusion, whereas the remaining 1-5% of cases may harbor one of several possible translocations, each resulting in a fusion gene containing a portion of the EWSR1 gene and a member of the ETS family of transcription factors.

UniProtKB/Swiss-Prot : 73 Ewing sarcoma: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.

Wikipedia : 74 Ewing's sarcoma is a type of cancer that forms in bone or soft tissue. Symptoms may include swelling and... more...

Related Diseases for Ewing Sarcoma

Diseases related to Ewing Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 1132, show less)
# Related Disease Score Top Affiliating Genes
1 extraosseous ewing sarcoma 35.5 EWSR1 ETV4 ETV1 ENO2 CD99
2 ewing sarcoma of bone 35.2 FLI1 EWSR1 ENO2 CD99
3 extraskeletal ewing sarcoma 35.2 FUS FLI1 EWSR1 ERG ENO2 CD99
4 extraosseous ewings sarcoma-primitive neuroepithelial tumor 35.0 EWSR1 ENO2 CD99
5 askin's tumor 33.7 FLII FLI1 EWSR1 ETV4 ETV1 ENO2
6 intracranial primitive neuroectodermal tumor 33.4 EWSR1 ENO2 CD99
7 sarcoma 33.3 XAGE1B XAGE1A TAF15 POU5F1 IGF1R FUS
8 cerebellopontine angle primitive neuroectodermal tumor 32.8 NCAM1 ENO2 CD99
9 rhabdomyosarcoma 32.2 XAGE1B XAGE1A IGF1R FLI1 EWSR1 ENO2
10 neuroblastoma 32.1 POU5F1 NF1 NCAM1 IGF1R FGFR1 EWSR1
11 sarcoma, synovial 31.8 NF1 IGF1R FUS FLI1 EWSR1 CD99
12 small cell osteogenic sarcoma 31.8 EWSR1 ENO2 CD99
13 teratoma 31.7 POU5F1 ENO2 CD99
14 leukemia, acute myeloid 31.7 POU5F1 NF1 NCAM1 IGF1R FGFR1 EWSR1
15 bone sarcoma 31.6 IGF1R FUS FLII EWSR1 ETV1 ENO2
16 liposarcoma 31.5 TAF15 IGF1R FUS EWSR1
17 kidney rhabdoid cancer 31.5 EWSR1 ENO2
18 medulloblastoma 31.5 POU5F1 NF1 NCAM1 IGF1R FGFR1 ENO2
19 olfactory neuroblastoma 31.4 EWSR1 ENO2 CD99
20 fibrous histiocytoma 31.4 FUS EWSR1 ENO2
21 lymphoblastic lymphoma 31.4 FLI1 FGFR1 CD99
22 merkel cell carcinoma 31.3 NCAM1 ENO2 CD99
23 clear cell sarcoma 31.3 FUS EWSR1 ENO2
24 rhabdomyosarcoma 2 31.3 IGF1R FLII EWSR1 ENO2
25 malignant teratoma 31.3 POU5F1 ENO2 CD99
26 connective tissue benign neoplasm 31.3 NF1 EWSR1 ENO2
27 cauda equina neoplasm 31.3 EWSR1 ENO2
28 subependymoma 31.3 NCAM1 ENO2
29 neuroendocrine tumor 31.3 NF1 NCAM1 IGF1R ENO2
30 myxoid liposarcoma 31.2 IGF1R FUS EWSR1 ERG
31 ganglioneuroma 31.2 NCAM1 ENO2 CD99
32 central nervous system primitive neuroectodermal neoplasm 31.2 ENO2 CD99
33 ectomesenchymoma 31.2 ENO2 CD99
34 extraosseous chondrosarcoma 31.2 TAF15 FUS EWSR1 ETV1 ENO2
35 wilms tumor 1 31.2 NCAM1 IGF1R EWSR1 ENO2 CD99
36 nasal cavity benign neoplasm 31.2 NCAM1 EWSR1
37 chondrosarcoma, extraskeletal myxoid 31.1 TAF15 FUS EWSR1 ETV4 ETV1 ENO2
38 peripheral nervous system neoplasm 31.1 NF1 NCAM1 EWSR1 ENO2
39 localized osteosarcoma 31.1 IGF1R EWSR1
40 paraganglioma 31.1 NF1 NCAM1 ENO2
41 muscle cancer 31.0 NF1 IGF1R EWSR1 ENO2 CD99
42 ring chromosome 31.0 IGF1R EWSR1
43 large cell carcinoma 30.9 NCAM1 FGFR1 ENO2
44 lung sarcoma 30.9 TAF15 EWSR1
45 gastrointestinal stromal tumor 30.8 NF1 NCAM1 ETV1 ENO2
46 malignant peripheral nerve sheath tumor 30.8 NF1 IGF1R EYA3
47 cellular myxoid liposarcoma 30.7 FUS EWSR1
48 lipomatosis, multiple 30.7 NF1 FUS FGFR1 EWSR1
49 gliosarcoma 30.6 NF1 FGFR1 ENO2
50 primitive neuroectodermal tumor of the cervix uteri 12.6
51 primitive neuroectodermal tumor of the corpus uteri 12.5
52 soft tissue peripheral neuroepithelioma 12.4
53 bone peripheral neuroepithelioma 12.3
54 dissociative seizures 12.2
55 islet cell tumor 12.1
56 pineoblastoma 12.0
57 supratentorial primitive neuroectodermal tumor 11.7
58 epithelioid sarcoma 11.7
59 emanuel syndrome 11.5
60 eisenmenger syndrome 11.5
61 rhabdoid tumor predisposition syndrome 2 11.5
62 functioning neuroendocrine tumor of pancreas 11.5
63 non-functioning neuroendocrine tumor of pancreas 11.5
64 continuous spike-wave during slow sleep syndrome 11.5
65 cerebral primitive neuroectodermal tumor 11.4
66 spindle cell sarcoma 11.4
67 spiradenoma 11.3
68 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 11.2
69 pudendal neuralgia 11.2
70 glucagonoma 11.2
71 diabetic mastopathy 11.2
72 adult central nervous system primitive neuroectodermal neoplasm 11.1
73 childhood central nervous system primitive neuroectodermal neoplasm 11.1
74 spinal cord primitive neuroectodermal neoplasm 11.1
75 childhood supratentorial embryonal tumor, not otherwise specified 11.1
76 serotonin-producing neuroendocrine tumor of pancreas 11.1
77 osteogenic sarcoma 10.9
78 central nervous system mesenchymal non-meningothelial tumor 10.8 EWSR1 ENO2 CD99
79 spinal cord oligodendroglioma 10.8 NF1 FGFR1 ENO2
80 extraskeletal mesenchymal chondrosarcoma 10.8 TAF15 EWSR1 CD99
81 neuroma 10.8 NF1 FGFR1 ENO2
82 synovium cancer 10.8 FUS EWSR1 CD99
83 olfactory nerve neoplasm 10.8 NCAM1 EWSR1 ENO2 CD99
84 cranial nerve malignant neoplasm 10.8 NCAM1 EWSR1 ENO2 CD99
85 cranial nerve neoplasm 10.8 NF1 NCAM1 EWSR1 ENO2 CD99
86 pacinian tumor 10.8 NF1 ENO2
87 retroperitoneal neuroblastoma 10.8 ENO2 CD99
88 cervical neuroblastoma 10.8 NCAM1 EWSR1 ENO2
89 extracranial neuroblastoma 10.8 NCAM1 EWSR1 ENO2
90 plexiform schwannoma 10.8 NF1 ENO2
91 skeletal muscle cancer 10.8 NF1 NCAM1 IGF1R EWSR1 ENO2 CD99
92 orbital cancer 10.8 NF1 NCAM1 ENO2
93 suppression of tumorigenicity 12 10.8 POU5F1 NCAM1 IGF1R FGFR1 ETV4 ETV1
94 dedifferentiated liposarcoma 10.8 IGF1R FUS EWSR1
95 anal neuroendocrine tumor 10.8 NCAM1 ENO2
96 optic nerve astrocytoma 10.8 NF1 ENO2
97 ureter transitional cell carcinoma 10.7 NCAM1 ENO2
98 auditory system benign neoplasm 10.7 NCAM1 ENO2
99 malignant triton tumor 10.7 NF1 ENO2
100 urinary bladder small cell neuroendocrine carcinoma 10.7 NCAM1 ENO2
101 ureter small cell carcinoma 10.7 NCAM1 ENO2
102 skin granular cell tumor 10.7 NF1 ENO2
103 gallbladder small cell carcinoma 10.7 NCAM1 ENO2
104 gastric small cell carcinoma 10.7 NCAM1 ENO2
105 sensory organ benign neoplasm 10.7 NCAM1 ENO2
106 ovarian large-cell neuroendocrine carcinoma 10.7 NCAM1 ENO2
107 gastric hemangioma 10.7 NCAM1 ENO2
108 cutaneous ganglioneuroma 10.7 NCAM1 ENO2
109 cerebral falx meningioma 10.7 NF1 ENO2
110 endobronchial lipoma 10.7 EWSR1 ENO2
111 endometrial small cell carcinoma 10.7 NCAM1 ENO2
112 cerebellum cancer 10.7 NF1 ENO2
113 colon neuroendocrine neoplasm 10.7 NCAM1 ENO2
114 nasal cavity olfactory neuroblastoma 10.7 NCAM1 ENO2
115 pulmonary neuroendocrine tumor 10.6 NCAM1 ENO2
116 prostate neuroendocrine neoplasm 10.6 NCAM1 ENO2
117 bone cancer 10.6
118 rare tumor 10.6
119 uterus leiomyosarcoma 10.6 FUS ENO2
120 mediastinal cancer 10.6 NCAM1 ENO2
121 neutropenia 10.5
122 middle cerebral artery infarction 10.5 NCAM1 ENO2
123 corpus callosum lipoma 10.5 NF1 FGFR1
124 soft tissue sarcoma 10.5
125 osteomyelitis 10.4
126 chondrosarcoma 10.4
127 desmoplastic small round cell tumor 10.4
128 cerebral hemisphere lipoma 10.4 NF1 FGFR1
129 leukemia, acute lymphoblastic 10.4
130 status epilepticus 10.4
131 low compliance bladder 10.4
132 leukemia 10.4
133 back pain 10.4
134 cystic teratoma 10.3
135 acoustic neuroma 10.3
136 myeloid leukemia 10.3
137 exophthalmos 10.3
138 alexithymia 10.3
139 conversion disorder 10.3
140 syphilis 10.3
141 wilms tumor 5 10.3
142 primary bone cancer 10.3
143 microcephaly, epilepsy, and diabetes syndrome 10.2
144 childhood acute lymphocytic leukemia 10.2
145 hypothyroidism 10.2
146 cerebrum cancer 10.2
147 ganglioglioma 10.2
148 mature teratoma 10.2
149 optic nerve glioma 10.2 NF1 ENO2
150 encephalopathy 10.2
151 neurogenic bladder 10.2
152 retinoblastoma 10.2
153 lymphoma 10.2
154 thrombocytopenia 10.2
155 familial retinoblastoma 10.2
156 chromosomal triplication 10.2
157 hemangioma 10.2
158 pulmonary tuberculosis 10.2
159 burkitt lymphoma 10.2
160 renal cell carcinoma, nonpapillary 10.2
161 polykaryocytosis inducer 10.2
162 insulin-like growth factor i 10.2
163 myelodysplastic syndrome 10.2
164 graft-versus-host disease 10.2
165 mesenchymal cell neoplasm 10.2
166 radiculopathy 10.2
167 mesenchymal chondrosarcoma 10.2
168 paraplegia 10.2
169 47,xyy 10.2
170 paresthesia 10.2
171 ependymoblastoma 10.2
172 strabismus 10.1
173 disseminated intravascular coagulation 10.1
174 nephrotic syndrome 10.1
175 grade iii astrocytoma 10.1
176 neurilemmoma of the fifth cranial nerve 10.1
177 cerebral neuroblastoma 10.1
178 malignant ependymoma 10.1
179 mechanical strabismus 10.1
180 uterine inversion 10.1
181 mixed germ cell tumor 10.1
182 malaria 10.1
183 dental abscess 10.1
184 malignant fibrous histiocytoma 10.1
185 intracranial hypertension 10.1
186 lymphoma, hodgkin, classic 10.1
187 fibrous dysplasia 10.1
188 adenoid cystic carcinoma 10.1
189 cauda equina syndrome 10.1
190 leiomyosarcoma 10.1
191 adenocarcinoma 10.1
192 pediatric osteosarcoma 10.1
193 severe combined immunodeficiency 10.1
194 myeloid sarcoma 10.1
195 posttransplant acute limbic encephalitis 10.1
196 thyroid carcinoma 10.1
197 thyroid tumor 10.1
198 multiple endocrine neoplasia, type i 10.1
199 childhood medulloblastoma 10.1
200 candidiasis 10.1
201 human immunodeficiency virus infectious disease 10.1
202 pleuropulmonary blastoma 10.1
203 plasmacytoma 10.1
204 embryoma 10.1
205 diabetes insipidus 10.1
206 epilepsy, focal, with speech disorder and with or without mental retardation 10.1
207 filariasis 10.1
208 tetanus 10.1
209 landau-kleffner syndrome 10.1
210 teratocarcinoma 10.1
211 major depressive disorder 10.1
212 mental depression 10.1
213 fibromyalgia 10.1
214 chronic fatigue syndrome 10.1
215 depression 10.1
216 psychogenic movement 10.1
217 popliteal cyst 10.1
218 tetralogy of fallot 10.1
219 plica syndrome 10.1
220 toxic shock syndrome 10.1
221 gangliocytoma 10.1
222 synovitis 10.1
223 breast adenocarcinoma 10.1
224 ovarian small cell carcinoma 10.1
225 cervix small cell carcinoma 10.1
226 villonodular synovitis 10.1
227 syncope 10.1
228 epithelioid hemangioendothelioma 10.1
229 bladder cancer 10.0
230 chordoma 10.0
231 myeloma, multiple 10.0
232 fibroma 10.0
233 exostosis 10.0
234 chondroma 10.0
235 chondroblastoma 10.0
236 epidural spinal canal neoplasm 10.0
237 unilateral retinoblastoma 10.0
238 t-cell lymphoblastic leukemia/lymphoma 10.0
239 in situ carcinoma 10.0
240 irritable bowel syndrome 10.0
241 leukemia, t-cell, chronic 10.0
242 virus-associated trichodysplasia spinulosa 10.0
243 primary bone lymphoma 10.0
244 cholera 10.0
245 dental caries 10.0
246 toxocariasis 10.0
247 intussusception 10.0
248 thyroid carcinoma, familial medullary 10.0
249 myositis 10.0
250 prostate cancer 10.0
251 torticollis 10.0
252 triiodothyronine receptor auxiliary protein 10.0
253 pancreatic cancer 10.0
254 reticulum cell sarcoma 10.0
255 cd4/cd8 t-cell ratio 10.0
256 lymphoma, non-hodgkin, familial 10.0
257 aneurysmal bone cysts 10.0
258 meningioma, radiation-induced 10.0
259 meningioma, familial 10.0
260 rhabdoid tumor predisposition syndrome 1 10.0
261 helix syndrome 10.0
262 angiosarcoma 10.0
263 small cell carcinoma 10.0
264 scoliosis 10.0
265 bone disease 10.0
266 bone resorption disease 10.0
267 hydronephrosis 10.0
268 respiratory failure 10.0
269 spinal meningioma 10.0
270 quadriplegia 10.0
271 diarrhea 10.0
272 neuroendocrine carcinoma 10.0
273 vulvar sarcoma 10.0
274 atypical teratoid rhabdoid tumor 10.0
275 small cell sarcoma 10.0
276 neurilemmoma 10.0
277 fibrosarcoma 10.0
278 mammary paget's disease 10.0
279 skin carcinoma 10.0
280 rhabdoid cancer 10.0
281 thyroid gland medullary carcinoma 10.0
282 ganglioneuroblastoma 10.0
283 secretory meningioma 10.0
284 lymphoplasmacyte-rich meningioma 10.0
285 myoepithelial carcinoma 10.0
286 benign ependymoma 10.0
287 cellular ependymoma 10.0
288 myxoid chondrosarcoma 10.0
289 bilateral breast cancer 10.0
290 b-cell lymphoma 10.0
291 neuropathy 10.0
292 neurofibromatosis 10.0
293 pulmonary embolism 10.0
294 48,xyyy 10.0
295 embryonal sarcoma 10.0
296 dysphagia 10.0
297 hypoxia 10.0
298 rare soft tissue tumor 10.0
299 pancreatic adenocarcinoma 10.0
300 medulloepithelioma 10.0
301 brain tumor, childhood 10.0
302 glioma 10.0
303 glial tumor 10.0
304 schistosoma mansoni infection, susceptibility/ 10.0
305 cervical cancer 10.0
306 human immunodeficiency virus type 1 10.0
307 mastitis 10.0
308 schistosomiasis 10.0
309 oral candidiasis 10.0
310 embryonal carcinoma 10.0
311 skin disease 10.0
312 trichinosis 10.0
313 muscular dystrophy 10.0
314 beckwith-wiedemann syndrome 10.0
315 epidermoid cysts 10.0
316 gray platelet syndrome 10.0
317 gilbert syndrome 10.0
318 systemic lupus erythematosus 10.0
319 ovarian cancer 10.0
320 renal hypodysplasia/aplasia 1 10.0
321 l-2-hydroxyglutaric aciduria 10.0
322 intracranial hypertension, idiopathic 10.0
323 moyamoya disease 1 10.0
324 papilloma of choroid plexus 10.0
325 budd-chiari syndrome 10.0
326 aspergillosis 10.0
327 2-hydroxyglutaric aciduria 10.0
328 adrenal cortical adenoma 10.0
329 marantic endocarditis 10.0
330 pain agnosia 10.0
331 benign teratoma 10.0
332 parotitis 10.0
333 sialadenitis 10.0
334 endocarditis 10.0
335 chronic meningitis 10.0
336 malignant hypertension 10.0
337 patau syndrome 10.0
338 intracranial vasospasm 10.0
339 tuberous sclerosis 10.0
340 squamous cell papilloma 10.0
341 gonadal dysgenesis 10.0
342 benign breast phyllodes tumor 10.0
343 hyperuricemia 10.0
344 adenosarcoma 10.0
345 rectum adenocarcinoma 10.0
346 hyperostosis 10.0
347 sensory peripheral neuropathy 10.0
348 papilloma 10.0
349 epidermolysis bullosa 10.0
350 endometrial adenocarcinoma 10.0
351 glomerulonephritis 10.0
352 papillary carcinoma 10.0
353 botryoid rhabdomyosarcoma 10.0
354 malignant fibrous histiocytoma of bone 10.0
355 turner syndrome 10.0
356 choroid plexus cancer 10.0
357 medullomyoblastoma 10.0
358 adult medulloblastoma 10.0
359 lynch syndrome 10.0
360 bladder urothelial carcinoma 10.0
361 endometrial stromal sarcoma 10.0
362 epidermolysis bullosa simplex 10.0
363 infratentorial cancer 10.0
364 epidermolysis bullosa dystrophica 10.0
365 pineal gland cancer 10.0
366 ovarian cystic teratoma 10.0
367 urinary tract obstruction 10.0
368 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
369 demyelinating polyneuropathy 10.0
370 hemangioblastoma 10.0
371 gingival hypertrophy 10.0
372 spinal cancer 10.0
373 nerve compression syndrome 10.0
374 uterine carcinosarcoma 10.0
375 fibrillary astrocytoma 10.0
376 pancreatoblastoma 10.0
377 pineal region germinoma 10.0
378 lupus erythematosus 10.0
379 pathologic nystagmus 10.0
380 anaplastic ependymoma 10.0
381 bronchogenic cyst 10.0
382 dendritic cell tumor 10.0
383 neural crest tumor 10.0
384 pineocytoma 10.0
385 precocious puberty 10.0
386 teratoma with malignant transformation 10.0
387 cerebral atrophy 10.0
388 thrombotic microangiopathy 10.0
389 rare renal tumor 10.0
390 bone mineral density quantitative trait locus 3 10.0
391 coloboma of macula 10.0
392 hepatitis c virus 10.0
393 microphthalmia 10.0
394 hepatitis 10.0
395 transitional cell carcinoma 10.0
396 bilateral retinoblastoma 10.0
397 brain edema 10.0
398 cerebellar degeneration 10.0
399 paraneoplastic cerebellar degeneration 10.0
400 down syndrome 10.0
401 exanthem 10.0
402 cysticercosis 10.0
403 trypanosomiasis 10.0
404 asphyxia neonatorum 10.0
405 diphtheria 10.0
406 urinary schistosomiasis 10.0
407 acquired immunodeficiency syndrome 10.0
408 measles 10.0
409 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.9
410 otitis media 9.9
411 small cell cancer of the lung 9.9
412 neural tube defects 9.9
413 immune deficiency disease 9.9
414 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 9.9
415 yemenite deaf-blind hypopigmentation syndrome 9.9
416 dengue virus 9.9
417 deficiency anemia 9.9
418 primary hyperparathyroidism 9.9
419 keratomalacia 9.9
420 filarial elephantiasis 9.9
421 typhoid fever 9.9
422 hyperparathyroidism 9.9
423 eclampsia 9.9
424 impotence 9.9
425 trichomoniasis 9.9
426 cerebral palsy 9.9
427 focal epilepsy 9.9
428 iron metabolism disease 9.9
429 substance abuse 9.9
430 peripheral nervous system disease 9.9
431 sickle cell disease 9.9
432 overgrowth syndrome 9.9
433 atrial standstill 1 9.9
434 lymphoma, mucosa-associated lymphoid type 9.9
435 leiomyoma, uterine 9.9
436 leukemia, acute monocytic 9.9
437 li-fraumeni syndrome 9.9
438 multicentric carpotarsal osteolysis syndrome 9.9
439 osteoporosis 9.9
440 wilms tumor 3 9.9
441 endocardial fibroelastosis 9.9
442 neuroblastoma 1 9.9
443 pulmonary alveolar microlithiasis 9.9
444 thymoma, familial 9.9
445 premature ovarian failure 1 9.9
446 chromosome 18q deletion syndrome 9.9
447 reflex sympathetic dystrophy 9.9
448 mycobacterium tuberculosis 1 9.9
449 li-fraumeni syndrome 2 9.9
450 bone mineral density quantitative trait locus 8 9.9
451 acute promyelocytic leukemia 9.9
452 bone mineral density quantitative trait locus 15 9.9
453 retinitis pigmentosa 55 9.9
454 beta-thalassemia 9.9
455 retinitis pigmentosa 75 9.9
456 juvenile arthritis 9.9
457 hypophosphatemia 9.9
458 mantle cell lymphoma 9.9
459 pulmonary adenocarcinoma in situ 9.9
460 ameloblastoma 9.9
461 ductal carcinoma in situ 9.9
462 umbilical hernia 9.9
463 salmonellosis 9.9
464 interstitial nephritis 9.9
465 cardiac tamponade 9.9
466 acute apical periodontitis 9.9
467 portal vein thrombosis 9.9
468 bladder sarcoma 9.9
469 penis sarcoma 9.9
470 trachea sarcoma 9.9
471 allergic hypersensitivity disease 9.9
472 spinal muscular atrophy 9.9
473 carotid stenosis 9.9
474 acute cystitis 9.9
475 coccidioidomycosis 9.9
476 pharyngoconjunctival fever 9.9
477 algoneurodystrophy 9.9
478 anus cancer 9.9
479 communicating hydrocephalus 9.9
480 melanotic neuroectodermal tumor 9.9
481 facial hemiatrophy 9.9
482 benign giant cell tumor 9.9
483 colon adenocarcinoma 9.9
484 dermis tumor 9.9
485 basal cell carcinoma 9.9
486 skin sarcoma 9.9
487 leydig cell tumor 9.9
488 laryngeal squamous cell carcinoma 9.9
489 testicular cancer 9.9
490 gallbladder cancer 9.9
491 myelitis 9.9
492 pleomorphic rhabdomyosarcoma 9.9
493 thymoma 9.9
494 bone inflammation disease 9.9
495 inappropriate adh syndrome 9.9
496 cellulitis 9.9
497 gallbladder adenocarcinoma 9.9
498 pulmonary fibrosis 9.9
499 pituitary-dependent cushing's disease 9.9
500 adrenal carcinoma 9.9
501 prostate sarcoma 9.9
502 hepatic tuberculosis 9.9
503 differentiating neuroblastoma 9.9
504 hypertrichosis 9.9
505 pustulosis of palm and sole 9.9
506 cutaneous fibrous histiocytoma 9.9
507 seminoma 9.9
508 clear cell adenocarcinoma 9.9
509 hypokalemia 9.9
510 blastema predominant kidney wilms' tumor 9.9
511 malignant mesenchymoma 9.9
512 bone lymphoma 9.9
513 juvenile rheumatoid arthritis 9.9
514 hepatoblastoma 9.9
515 cloacogenic carcinoma 9.9
516 fibrosarcomatous osteosarcoma 9.9
517 end stage renal disease 9.9
518 actinomycosis 9.9
519 monocytic leukemia 9.9
520 psoriasis 9.9
521 herpes zoster oticus 9.9
522 neurofibroma 9.9
523 acute monoblastic leukemia 9.9
524 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9
525 aminoaciduria 9.9
526 enchondroma 9.9
527 guttate psoriasis 9.9
528 hypertrichosis lanuginosa, acquired 9.9
529 lymphosarcoma 9.9
530 nephrogenic systemic fibrosis 9.9
531 transverse myelitis 9.9
532 fainting 9.9
533 partial deletion of the long arm of chromosome 18 9.9
534 genetic hemoglobinopathy 9.9
535 pik3ca-related overgrowth syndrome 9.9
536 neurofibromatosis, type ii 9.9
537 anisocoria 9.9
538 gastroesophageal reflux 9.9
539 colorectal cancer 9.9
540 hepatocellular carcinoma 9.9
541 kaposi sarcoma 9.9
542 leukemia, chronic lymphocytic 9.9
543 migraine with or without aura 1 9.9
544 nail-patella syndrome 9.9
545 nephrolithiasis, calcium oxalate 9.9
546 pachyonychia congenita 1 9.9
547 protrusio acetabuli 9.9
548 spondylolisthesis 9.9
549 thrombophilia due to thrombin defect 9.9
550 uterus bicornis bicollis with partial vaginal septum and unilateral hematocolpos with ipsilateral renal agenesis 9.9
551 williams-beuren syndrome 9.9
552 zinc finger protein 1 9.9
553 anemia, hypochromic microcytic, with iron overload 1 9.9
554 ataxia-telangiectasia 9.9
555 hemangiopericytoma, malignant 9.9
556 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
557 3-methylglutaconic aciduria, type iii 9.9
558 osteoid osteoma 9.9
559 werner syndrome 9.9
560 ataxia and polyneuropathy, adult-onset 9.9
561 kearns-sayre syndrome 9.9
562 retinitis pigmentosa 11 9.9
563 fragile site 11b 9.9
564 branchiootic syndrome 1 9.9
565 langerhans cell histiocytosis 9.9
566 alveolar soft part sarcoma 9.9
567 body mass index quantitative trait locus 1 9.9
568 leukemia, chronic myeloid 9.9
569 lung cancer susceptibility 3 9.9
570 neuroblastoma 2 9.9
571 neuroblastoma 4 9.9
572 gastric cancer 9.9
573 pachyonychia congenita 3 9.9
574 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
575 tendinitis 9.9
576 hypochromic microcytic anemia 9.9
577 anaplastic large cell lymphoma 9.9
578 diffuse large b-cell lymphoma 9.9
579 hemorrhagic cystitis 9.9
580 large cell neuroendocrine carcinoma 9.9
581 osteoblastoma 9.9
582 cartilage cancer 9.9
583 ptosis 9.9
584 inguinal hernia 9.9
585 mastoiditis 9.9
586 thrombosis 9.9
587 hereditary lymphedema i 9.9
588 hepatic veno-occlusive disease 9.9
589 mucositis 9.9
590 chronic myelomonocytic leukemia 9.9
591 acquired von willebrand syndrome 9.9
592 sensorineural hearing loss 9.9
593 pleurisy 9.9
594 charcot-marie-tooth disease 9.9
595 premature menopause 9.9
596 hydrocephalus 9.9
597 tooth disease 9.9
598 ovarian disease 9.9
599 pertussis 9.9
600 epidural abscess 9.9
601 esophagitis 9.9
602 synostosis 9.9
603 cryptococcosis 9.9
604 von willebrand's disease 9.9
605 acute leukemia 9.9
606 leiomyoma 9.9
607 telangiectasis 9.9
608 excessive tearing 9.9
609 sick sinus syndrome 9.9
610 facial paralysis 9.9
611 amenorrhea 9.9
612 spinal cord sarcoma 9.9
613 obstructive hydrocephalus 9.9
614 pleuropneumonia 9.9
615 papilledema 9.9
616 lymphangioma 9.9
617 dermatomycosis 9.9
618 keratosis 9.9
619 pneumothorax 9.9
620 cystitis 9.9
621 optic nerve disease 9.9
622 hereditary multiple exostoses 9.9
623 intestinal perforation 9.9
624 brain sarcoma 9.9
625 cystadenoma 9.9
626 benign mesothelioma 9.9
627 myoepithelioma 9.9
628 larynx sarcoma 9.9
629 acute kidney failure 9.9
630 astrocytoma 9.9
631 malignant glioma 9.9
632 skin benign neoplasm 9.9
633 embryonal rhabdomyosarcoma 9.9
634 chondroblastic osteosarcoma 9.9
635 bone osteosarcoma 9.9
636 histiocytosis 9.9
637 pericoronitis 9.9
638 plexopathy 9.9
639 pituitary adenoma 9.9
640 craniopharyngioma 9.9
641 intracranial thrombosis 9.9
642 carcinosarcoma 9.9
643 kidney sarcoma 9.9
644 myofibroma 9.9
645 childhood kidney cell carcinoma 9.9
646 sarcomatoid mesothelioma 9.9
647 infertility 9.9
648 heart sarcoma 9.9
649 small intestinal sarcoma 9.9
650 biphasic synovial sarcoma 9.9
651 pneumonia 9.9
652 kidney disease 9.9
653 nephrolithiasis 9.9
654 congestive heart failure 9.9
655 lymphopenia 9.9
656 cowden syndrome 9.9
657 adenoma 9.9
658 pseudosarcomatous fibromatosis 9.9
659 muscular atrophy 9.9
660 septic arthritis 9.9
661 periodontitis 9.9
662 peritonitis 9.9
663 intestinal obstruction 9.9
664 ileus 9.9
665 arthritis 9.9
666 lung disease 9.9
667 herpes zoster 9.9
668 reticulosarcoma 9.9
669 vasculitis 9.9
670 gas gangrene 9.9
671 encephalitis 9.9
672 fasciitis 9.9
673 stomatitis 9.9
674 periostitis 9.9
675 triple x syndrome 9.9
676 hereditary multiple osteochondromas 9.9
677 acute graft versus host disease 9.9
678 double uterus-hemivagina-renal agenesis 9.9
679 germ cells tumors 9.9
680 granulocytopenia 9.9
681 limbic encephalitis 9.9
682 osteochondroma 9.9
683 sacral plexopathy 9.9
684 splenomegaly 9.9
685 sudden sensorineural hearing loss 9.9
686 uterine sarcoma 9.9
687 foot drop 9.9
688 rare tumor of pancreas 9.9
689 b-cell non-hodgkin lymphoma 9.9
690 rapidly involuting congenital hemangioma 9.9
691 rare hemorrhagic disorder 9.9
692 central nervous system embryonal tumor 9.9
693 trisomy 1q 9.9
694 specific language disorder 9.9
695 rare lymphatic malformation 9.9
696 acute sensory ataxic neuropathy 9.9
697 alk-positive anaplastic large cell lymphoma 9.9
698 avascular necrosis 9.9
699 primary lymphedema 9.9
700 solitary bone cyst 9.9
701 polyploidy 9.9
702 monosomy 22 9.9
703 smith-magenis syndrome 9.9
704 von hippel-lindau syndrome 9.9
705 cerebellar medulloblastoma 9.9
706 portal hypertension 9.9
707 central neurocytoma 9.9
708 endocrine gland cancer 9.9
709 endodermal sinus tumor 9.9
710 acromegaly 9.9
711 splenic infarction 9.9
712 kidney cancer 9.9
713 oligodendroglioma 9.9
714 germinoma 9.9
715 extragonadal germ cell cancer 9.9
716 testicular yolk sac tumor 9.9
717 juvenile pilocytic astrocytoma 9.9
718 mediastinal malignant lymphoma 9.9
719 astroblastoma 9.9
720 cataract 9.9
721 nonseminomatous germ cell tumor 9.9
722 low-grade astrocytoma 9.9
723 breast cancer 9.9
724 parkinson disease, late-onset 9.9
725 meester-loeys syndrome 9.9
726 megalencephalic leukoencephalopathy with subcortical cysts 2a 9.9
727 alacrima, achalasia, and mental retardation syndrome 9.9
728 aphasia 9.9
729 pre-eclampsia 9.9
730 rickets 9.9
731 chlamydia 9.9
732 heart disease 9.9
733 hypertensive heart disease 9.9
734 hepatitis a 9.9
735 tetanus neonatorum 9.9
736 alcohol use disorder 9.9
737 lymphadenitis 9.9
738 vascular disease 9.9
739 epilepsy 9.9
740 hemoglobinopathy 9.9
741 gingivitis 9.9
742 insulinoma 9.9
743 liver disease 9.9
744 hyperglycemia 9.9
745 dystonia 9.9
746 bronchitis 9.9
747 herpes simplex 9.9
748 alopecia 9.9
749 developmental coordination disorder 9.9
750 developmental dyspraxia 9.9
751 spasticity 9.9
752 spinal cord injury 9.9
753 pneumothorax, primary spontaneous 9.8
754 papillary adenocarcinoma 9.8
755 mismatch repair cancer syndrome 9.8
756 neu-laxova syndrome 2 9.8
757 xerophthalmia 9.8
758 keratoconjunctivitis sicca 9.8
759 spindle cell carcinoma 9.8
760 erythroleukemia, familial 9.8
761 huntington disease 9.8
762 hypercholesterolemia, familial, 1 9.8
763 thyroid cancer, nonmedullary, 1 9.8
764 fanconi anemia, complementation group a 9.8
765 muscular dystrophy, duchenne type 9.8
766 anxiety 9.8
767 aplastic anemia 9.8
768 hearing loss, noise-induced 9.8
769 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.8
770 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.8
771 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.8
772 peripheral vascular disease 9.8
773 pulmonary hypertension 9.8
774 acute diarrhea 9.8
775 extrapulmonary tuberculosis 9.8
776 cervical dystonia 9.8
777 apraxia 9.8
778 oral hairy leukoplakia 9.8
779 christianson syndrome 9.8
780 cryptococcal meningitis 9.8
781 pleural tuberculosis 9.8
782 microcephaly 9.8
783 amnestic disorder 9.8
784 anogenital venereal wart 9.8
785 hypoparathyroidism 9.8
786 hemopericardium 9.8
787 choledocholithiasis 9.8
788 iron deficiency anemia 9.8
789 pericardial effusion 9.8
790 visual epilepsy 9.8
791 dysentery 9.8
792 dilated cardiomyopathy 9.8
793 polyneuropathy 9.8
794 plasmodium falciparum malaria 9.8
795 dumping syndrome 9.8
796 echinococcosis 9.8
797 viral hepatitis 9.8
798 rectum cancer 9.8
799 hepatitis b 9.8
800 cervicitis 9.8
801 dermatitis 9.8
802 endometriosis 9.8
803 multiple endocrine neoplasia 9.8
804 benign epilepsy with centrotemporal spikes 9.8
805 vaginal discharge 9.8
806 pleural empyema 9.8
807 tinea capitis 9.8
808 pancreatitis 9.8
809 gastrointestinal system disease 9.8
810 retinal degeneration 9.8
811 dermatophytosis 9.8
812 cervix uteri carcinoma in situ 9.8
813 diabetes mellitus 9.8
814 cholangitis 9.8
815 bacterial meningitis 9.8
816 meningitis 9.8
817 yellow fever 9.8
818 toxoplasmosis 9.8
819 hypereosinophilic syndrome 9.8
820 hypoglycemia 9.8
821 pink1 type of young-onset parkinson disease 9.8
822 cervical intraepithelial neoplasia 9.8
823 leukoplakia 9.8
824 tuberculous meningitis 9.8
825 brain injury 9.8
826 head injury 9.8
827 headache 9.8
828 seizure disorder 9.8
829 traumatic brain injury 9.8
830 familial nonmedullary thyroid carcinoma 9.8
831 amyotrophic lateral sclerosis 1 9.6
832 angelman syndrome 9.6
833 atherosclerosis susceptibility 9.6
834 autoimmune disease 9.6
835 cleft palate, isolated 9.6
836 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.6
837 hyperparathyroidism 1 9.6
838 hypertension, essential 9.6
839 hypertriglyceridemia, familial 9.6
840 multiple system atrophy 1 9.6
841 ige responsiveness, atopic 9.6
842 kabuki syndrome 1 9.6
843 marfan syndrome 9.6
844 macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 9.6
845 nondisjunction 9.6
846 neurofibromatosis, type i 9.6
847 papillomatosis, confluent and reticulated 9.6
848 parkinson disease 1, autosomal dominant 9.6
849 pheochromocytoma 9.6
850 prader-willi syndrome 9.6
851 pyloric stenosis, infantile hypertrophic, 1 9.6
852 dowling-degos disease 1 9.6
853 rheumatoid arthritis 9.6
854 scoliosis, isolated 1 9.6
855 chromosome 2q35 duplication syndrome 9.6
856 testicular torsion 9.6
857 thyroid cancer, nonmedullary, 2 9.6
858 suppressor of tumorigenicity 3 9.6
859 varicose veins 9.6
860 vitiligo-associated multiple autoimmune disease susceptibility 6 9.6
861 acrocephalopolydactylous dysplasia 9.6
862 adrenocortical carcinoma, hereditary 9.6
863 fetal akinesia deformation sequence 1 9.6
864 autism 9.6
865 lung cancer 9.6
866 charge syndrome 9.6
867 corneal endothelial dystrophy 9.6
868 hydrops fetalis, nonimmune 9.6
869 hyperparathyroidism, neonatal severe 9.6
870 leprosy 3 9.6
871 metachromatic leukodystrophy 9.6
872 methane production 9.6
873 myasthenia gravis 9.6
874 epilepsy, myoclonic juvenile 9.6
875 ocular motor apraxia 9.6
876 parkinson disease 15, autosomal recessive early-onset 9.6
877 retinitis pigmentosa 9.6
878 schizencephaly 9.6
879 short stature-obesity syndrome 9.6
880 testicular germ cell tumor 9.6
881 muscular dystrophy, becker type 9.6
882 parkinson disease 12 9.6
883 arts syndrome 9.6
884 hemophilia a 9.6
885 parkinson disease 2, autosomal recessive juvenile 9.6
886 dysphasia, familial developmental 9.6
887 gallbladder disease 1 9.6
888 timothy syndrome 9.6
889 supranuclear palsy, progressive, 1 9.6
890 autoimmune lymphoproliferative syndrome 9.6
891 parkinson disease 3, autosomal dominant 9.6
892 polydactyly 9.6
893 deafness, autosomal dominant 17 9.6
894 amegakaryocytic thrombocytopenia, congenital 9.6
895 parkinson disease 4, autosomal dominant 9.6
896 parkinson disease 6, autosomal recessive early-onset 9.6
897 parkinson disease 7, autosomal recessive early-onset 9.6
898 vitiligo-associated multiple autoimmune disease susceptibility 1 9.6
899 kufor-rakeb syndrome 9.6
900 parkinson disease 10 9.6
901 parkinson disease 8, autosomal dominant 9.6
902 nasopharyngeal carcinoma 9.6
903 parkinson disease 11, autosomal dominant 9.6
904 endometrial cancer 9.6
905 kala-azar 1 9.6
906 restless legs syndrome 2 9.6
907 parkinson disease 13, autosomal dominant 9.6
908 kawasaki disease 9.6
909 diabetes mellitus, ketosis-prone 9.6
910 microvascular complications of diabetes 3 9.6
911 microvascular complications of diabetes 4 9.6
912 microvascular complications of diabetes 6 9.6
913 microvascular complications of diabetes 7 9.6
914 parkinson disease 14, autosomal recessive 9.6
915 parkinson disease 16 9.6
916 ectodermal dysplasia-syndactyly syndrome 2 9.6
917 parkinson disease 5, autosomal dominant 9.6
918 muscle hypertrophy 9.6
919 parkinson disease 17 9.6
920 parkinson disease 18, autosomal dominant 9.6
921 barrett esophagus 9.6
922 parkinson disease 19a, juvenile-onset 9.6
923 parkinson disease 20, early-onset 9.6
924 leukemia, acute lymphoblastic 3 9.6
925 melanoma, cutaneous malignant 10 9.6
926 parkinson disease 21 9.6
927 parkinson disease 22, autosomal dominant 9.6
928 parkinson disease 23, autosomal recessive early-onset 9.6
929 joint laxity, short stature, and myopia 9.6
930 polymicrogyria with or without vascular-type ehlers-danlos syndrome 9.6
931 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.6
932 adrenal cortical carcinoma 9.6
933 tick-borne encephalitis 9.6
934 restless legs syndrome 9.6
935 taeniasis 9.6
936 autosomal recessive disease 9.6
937 rheumatic heart disease 9.6
938 adrenal gland pheochromocytoma 9.6
939 autism spectrum disorder 9.6
940 sexual disorder 9.6
941 colitis 9.6
942 basal ganglia calcification 9.6
943 stuttering 9.6
944 specific language impairment 9.6
945 idiopathic scoliosis 9.6
946 porencephaly 9.6
947 paroxysmal nocturnal hemoglobinuria 9.6
948 angular cheilitis 9.6
949 cardiac arrest 9.6
950 lymphoproliferative syndrome 9.6
951 progressive familial intrahepatic cholestasis 9.6
952 childhood t-cell acute lymphoblastic leukemia 9.6
953 childhood b-cell acute lymphoblastic leukemia 9.6
954 covid-19 9.6
955 middle east respiratory syndrome 9.6
956 sparganosis 9.6
957 sleeping sickness 9.6
958 neuroretinitis 9.6
959 esophageal lipoma 9.6
960 pleomorphic lipoma 9.6
961 cholelithiasis 9.6
962 thalassemia 9.6
963 mumps 9.6
964 bacterial infectious disease 9.6
965 common cold 9.6
966 meningoencephalitis 9.6
967 leukodystrophy 9.6
968 giardiasis 9.6
969 mesenteric lymphadenitis 9.6
970 meningocele 9.6
971 spastic diplegia 9.6
972 hemiplegia 9.6
973 bullous keratopathy 9.6
974 depersonalization disorder 9.6
975 brucellosis 9.6
976 parathyroid gland disease 9.6
977 suppurative otitis media 9.6
978 fungal meningitis 9.6
979 polycystic ovary syndrome 9.6
980 hyperandrogenism 9.6
981 lyme disease 9.6
982 protein-energy malnutrition 9.6
983 myopia 9.6
984 hypertrophic cardiomyopathy 9.6
985 hemosiderosis 9.6
986 pica disease 9.6
987 dengue disease 9.6
988 dengue hemorrhagic fever 9.6
989 marasmus 9.6
990 tinea pedis 9.6
991 pancytopenia 9.6
992 hypertrophic pyloric stenosis 9.6
993 pyloric stenosis 9.6
994 diabetic polyneuropathy 9.6
995 conduct disorder 9.6
996 relapsing fever 9.6
997 brain cancer 9.6
998 congenital toxoplasmosis 9.6
999 osteopetrosis 9.6
1000 kwashiorkor 9.6
1001 cholestasis 9.6
1002 obstructive jaundice 9.6
1003 biliary atresia 9.6
1004 familial hypercholesterolemia 9.6
1005 bacteriuria 9.6
1006 chronic purulent otitis media 9.6
1007 acute cholangitis 9.6
1008 disease of mental health 9.6
1009 thrombocytopenia due to platelet alloimmunization 9.6
1010 endogenous depression 9.6
1011 duodenal ulcer 9.6
1012 cheilitis 9.6
1013 pericarditis 9.6
1014 hepatitis c 9.6
1015 melanoma 9.6
1016 cholecystitis 9.6
1017 encephalomalacia 9.6
1018 post-traumatic stress disorder 9.6
1019 constipation 9.6
1020 vaginitis 9.6
1021 granulomatous hepatitis 9.6
1022 pharyngitis 9.6
1023 keratopathy 9.6
1024 lateral sclerosis 9.6
1025 gastroenteritis 9.6
1026 psychotic disorder 9.6
1027 opiate dependence 9.6
1028 cervix carcinoma 9.6
1029 acute pancreatitis 9.6
1030 newcastle disease 9.6
1031 iga glomerulonephritis 9.6
1032 germ cell cancer 9.6
1033 glioblastoma multiforme 9.6
1034 early myoclonic encephalopathy 9.6
1035 lipid metabolism disorder 9.6
1036 ischemia 9.6
1037 bacterial vaginosis 9.6
1038 retinitis 9.6
1039 hermaphroditism 9.6
1040 adrenal cortical adenocarcinoma 9.6
1041 gastritis 9.6
1042 duodenogastric reflux 9.6
1043 dyslexia 9.6
1044 avian influenza 9.6
1045 retrograde amnesia 9.6
1046 ludwig's angina 9.6
1047 movement disease 9.6
1048 poliomyelitis 9.6
1049 neurotic disorder 9.6
1050 elephantiasis 9.6
1051 essential tremor 9.6
1052 myxopapillary ependymoma 9.6
1053 sleep disorder 9.6
1054 lice infestation 9.6
1055 testicular germ cell cancer 9.6
1056 t-cell acute lymphoblastic leukemia 9.6
1057 adult acute lymphocytic leukemia 9.6
1058 eye disease 9.6
1059 retinal disease 9.6
1060 salpingitis 9.6
1061 endometrial serous adenocarcinoma 9.6
1062 hemoglobinuria 9.6
1063 panic disorder 9.6
1064 acute stress disorder 9.6
1065 conjunctivitis 9.6
1066 viral encephalitis 9.6
1067 mitochondrial metabolism disease 9.6
1068 thyroiditis 9.6
1069 placenta disease 9.6
1070 appendicitis 9.6
1071 polyhydramnios 9.6
1072 eating disorder 9.6
1073 bacterial pneumonia 9.6
1074 seborrheic dermatitis 9.6
1075 pyomyositis 9.6
1076 parasitic helminthiasis infectious disease 9.6
1077 fascioliasis 9.6
1078 learning disability 9.6
1079 evans' syndrome 9.6
1080 zellweger syndrome 9.6
1081 pityriasis versicolor 9.6
1082 leishmaniasis 9.6
1083 rem sleep behavior disorder 9.6
1084 visceral leishmaniasis 9.6
1085 achalasia 9.6
1086 amebiasis 9.6
1087 speech disorder 9.6
1088 homocystinuria 9.6
1089 cleft lip 9.6
1090 allergic asthma 9.6
1091 otitis externa 9.6
1092 necrotizing fasciitis 9.6
1093 alopecia areata 9.6
1094 heroin dependence 9.6
1095 hemophilia 9.6
1096 muscular dystrophy, duchenne and becker type 9.6
1097 myotonic dystrophy 9.6
1098 dyt1 early-onset isolated dystonia 9.6
1099 mitochondrial disorders 9.6
1100 polymicrogyria 9.6
1101 auditory neuropathy spectrum disorder 9.6
1102 coronary artery aneurysm 9.6
1103 dentinogenesis imperfecta type 2 9.6
1104 epilepsy with myoclonic-atonic seizures 9.6
1105 fournier gangrene 9.6
1106 haemophilus influenzae 9.6
1107 hansen's disease 9.6
1108 hemangioendothelioma 9.6
1109 human t-cell leukemia virus type 1 9.6
1110 mosaic trisomy 8 9.6
1111 tetraploidy 9.6
1112 triploidy 9.6
1113 trisomy 22 9.6
1114 chronic pain 9.6
1115 febrile seizures 9.6
1116 hypotonia 9.6
1117 myoclonus 9.6
1118 tremor 9.6
1119 isolated cleft lip 9.6
1120 cleft lip/palate 9.6
1121 unilateral polymicrogyria 9.6
1122 rare vascular tumor 9.6
1123 rare hereditary hemochromatosis 9.6
1124 familial papillary or follicular thyroid carcinoma 9.6
1125 pre-descemet corneal dystrophy 9.6
1126 familial intrahepatic cholestasis 9.6
1127 hereditary late-onset parkinson disease 9.6
1128 postpartum psychosis 9.6
1129 pneumococcal meningitis 9.6
1130 acute liver failure 9.6
1131 benign childhood occipital epilepsy, panayiotopoulos type 9.6
1132 precursor t-cell acute lymphoblastic leukemia 9.6

Graphical network of the top 20 diseases related to Ewing Sarcoma:



Diseases related to Ewing Sarcoma

Symptoms & Phenotypes for Ewing Sarcoma

Human phenotypes related to Ewing Sarcoma:

58 31 (showing 40, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 peripheral primitive neuroectodermal neoplasm 58 31 obligate (100%) Obligate (100%) HP:0030067
2 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
3 anemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001903
4 pruritus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000989
5 ascites 58 31 occasional (7.5%) Occasional (29-5%) HP:0001541
6 nausea and vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002017
7 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
8 back pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0003418
9 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
10 vertigo 58 31 occasional (7.5%) Occasional (29-5%) HP:0002321
11 hyporeflexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001265
12 headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0002315
13 abnormal bleeding 58 31 occasional (7.5%) Occasional (29-5%) HP:0001892
14 spinal cord tumor 58 31 occasional (7.5%) Occasional (29-5%) HP:0010302
15 ovarian neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0100615
16 torticollis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000473
17 neoplasm of the pancreas 58 31 occasional (7.5%) Occasional (29-5%) HP:0002894
18 sensory impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0003474
19 abdominal distention 58 31 occasional (7.5%) Occasional (29-5%) HP:0003270
20 pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001733
21 uterine neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0010784
22 abnormality of the scalp 58 31 occasional (7.5%) Occasional (29-5%) HP:0001965
23 abnormality of the thoracic spine 58 31 occasional (7.5%) Occasional (29-5%) HP:0100711
24 lower limb muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0007340
25 metrorrhagia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100608
26 episodic abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002574
27 brain neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0030692
28 upper limb pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0012513
29 elevated carcinoma antigen 125 level 58 31 occasional (7.5%) Occasional (29-5%) HP:0031030
30 pelvic mass 58 31 occasional (7.5%) Occasional (29-5%) HP:0031501
31 seizure 31 occasional (7.5%) HP:0001250
32 proptosis 58 31 very rare (1%) Very rare (<4-1%) HP:0000520
33 precocious puberty 58 31 very rare (1%) Very rare (<4-1%) HP:0000826
34 elevated alpha-fetoprotein 58 31 very rare (1%) Very rare (<4-1%) HP:0006254
35 abnormality of the superior cerebellar peduncle 58 31 very rare (1%) Very rare (<4-1%) HP:0011932
36 neoplasm of the scrotum 58 31 very rare (1%) Very rare (<4-1%) HP:0100849
37 increased lactate dehydrogenase level 31 very rare (1%) HP:0025435
38 seizures 58 Occasional (29-5%)
39 ewing sarcoma 31 HP:0012254
40 increased lactate dehydrogenase activity 58 Very rare (<4-1%)

Clinical features from OMIM:

612219

UMLS symptoms related to Ewing Sarcoma:


fever, visual disturbance, eye manifestations, pathological conditions, signs and symptoms, redness or discharge of eye, pain in or around eye, lid retraction

GenomeRNAi Phenotypes related to Ewing Sarcoma according to GeneCards Suite gene sharing:

26 (showing 31, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 9.95 CD99
2 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.95 XAGE1A XAGE1B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.95 NF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.95 NF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.95 ERG
6 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.95 XAGE1A XAGE1B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.95 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.95 CD99
9 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.95 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.95 CD99
11 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.95 XAGE1A XAGE1B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.95 NF1 POU5F1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.95 IGF1R
14 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.95 POU5F1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.95 CD99
16 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.95 ERG
17 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.95 CD99
18 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.95 POU5F1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.95 XAGE1A XAGE1B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-204 9.95 NF1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.95 CD99 ERG
22 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.95 POU5F1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.95 POU5F1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.95 CD99
25 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.95 NF1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.95 XAGE1A XAGE1B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.95 IGF1R
28 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.95 NF1 POU5F1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.95 CD99
30 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.95 IGF1R
31 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.95 CD99

MGI Mouse Phenotypes related to Ewing Sarcoma:

45 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 ERG ETV4 FGFR1 FLI1 FLII IGF1R
2 nervous system MP:0003631 9.36 ENO2 ERG ETV1 ETV4 FEV FGFR1

Drugs & Therapeutics for Ewing Sarcoma

Drugs for Ewing Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 307, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4
Epirubicin Approved Phase 3 56420-45-2 41867
5
Donepezil Approved Phase 3 120014-06-4 3152
6
Ondansetron Approved Phase 3 99614-02-5 4595
7
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
8
Lenograstim Approved, Investigational Phase 3 135968-09-1
9
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
10
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
11
leucovorin Approved Phase 3 58-05-9 6006 143
12 Grape Approved Phase 3
13 Cranberry Approved, Investigational Phase 3
14
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
15
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
16
Daunorubicin Approved Phase 3 20830-81-3 30323
17
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
18
Isotretinoin Approved Phase 3 4759-48-2 5282379 5538
19
Fluorouracil Approved Phase 3 51-21-8 3385
20
Streptozocin Approved, Investigational Phase 3 18883-66-4 29327
21
Histamine Approved, Investigational Phase 3 51-45-6 774
22
Cyproheptadine Approved Phase 3 129-03-3 2913
23
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
24
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 444795 5538
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26
Treosulfan Investigational Phase 3 299-75-2 9296
27
Camptothecin Experimental Phase 3 7689-03-4
28 Narcotics Phase 3
29 Analgesics, Opioid Phase 3
30 Anesthetics, General Phase 3
31 Anesthetics, Intravenous Phase 3
32 Antiemetics Phase 3
33 Diphosphonates Phase 3
34 Cholinesterase Inhibitors Phase 3
35 Cholinergic Agents Phase 3
36 Emetics Phase 3
37 Trace Elements Phase 3
38 Nutrients Phase 3
39 Micronutrients Phase 3
40 Vitamin B Complex Phase 3
41 Folic Acid Antagonists Phase 3
42 Folate Phase 3
43 Vitamin B9 Phase 3
44 Antineoplastic Agents, Hormonal Phase 2, Phase 3
45 Calcium, Dietary Phase 3
46 Dermatologic Agents Phase 3
47 Keratolytic Agents Phase 3
48 Podophyllotoxin Phase 3 518-28-5
49 Vitamins Phase 3
50 Antidotes Phase 3
51 Contraceptive Agents Phase 2, Phase 3
52 Triptorelin Pamoate Phase 2, Phase 3
53 Gastrointestinal Agents Phase 3
54 Histamine Antagonists Phase 3
55 Anti-Allergic Agents Phase 3
56
Histamine Phosphate Phase 3 51-74-1 65513
57 Histamine H1 Antagonists Phase 3
58
Calcium Nutraceutical Phase 3 7440-70-2 271
59
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
60
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
61
Metformin Approved Phase 2 657-24-9 14219 4091
62
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
63
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
64
Glycerol Approved, Investigational Phase 2 56-81-5 753
65
Cobalt Approved, Experimental Phase 2 7440-48-4 104729
66
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
67
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
68
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
69
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
70
Vinorelbine Approved, Investigational Phase 2 71486-22-1 60780 44424639
71
Talazoparib Approved, Investigational Phase 1, Phase 2 1207456-01-6 135565082
72
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865