MCID: EWN004
MIFTS: 29

Ewing Sarcoma of Bone

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Ewing Sarcoma of Bone

MalaCards integrated aliases for Ewing Sarcoma of Bone:

Name: Ewing Sarcoma of Bone 12 15
Ewing's Sarcoma/bone Peripheral Primitive Neuroectodermal Tumor 12
Localized Skeletal Ewing's Sarcoma 12
Bone Localized Ewing's Sarcoma 12
Bone Localized Ewing Sarcoma 12
Ewing's Sarcoma of Bone 12
Bone Ewing's Sarcoma 12
Bone Ewing Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3368
SNOMED-CT 67 307608006
UMLS 71 C0585474 C1333481 C1334406

Summaries for Ewing Sarcoma of Bone

Disease Ontology : 12 A peripheral primitive neuroectodermal tumor that is located in bone.

MalaCards based summary : Ewing Sarcoma of Bone, also known as ewing's sarcoma/bone peripheral primitive neuroectodermal tumor, is related to spindle cell sarcoma and ewing sarcoma. An important gene associated with Ewing Sarcoma of Bone is EWSR1 (EWS RNA Binding Protein 1). The drugs Vincristine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is nervous system.

Related Diseases for Ewing Sarcoma of Bone

Diseases related to Ewing Sarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 31.1 VIM EWSR1
2 ewing sarcoma 30.8 VIM FLII FLI1 EWSR1 ENO2 CHGA
3 sarcoma 30.3 VIM FLI1 FES EWSR1
4 chondrosarcoma 30.1 VIM EWSR1 ENO2
5 small cell osteogenic sarcoma 29.9 EWSR1 ENO2 CD99
6 rhabdomyosarcoma 29.5 VIM FLI1 EWSR1 ENO2 CD99
7 primary hepatic neuroendocrine carcinoma 10.3 VIM CHGA
8 esophageal adenoid cystic carcinoma 10.3 VIM CHGA
9 parachordoma 10.3 VIM CHGA
10 chordoid meningioma 10.3 VIM CHGA
11 rhabdoid cancer 10.2 VIM EWSR1
12 clear cell meningioma 10.2 VIM CHGA
13 vaginal glandular tumor 10.2 ENO2 CHGA
14 ureter transitional cell carcinoma 10.2 ENO2 CHGA
15 bladder leiomyoma 10.2 VIM EWSR1
16 auditory system benign neoplasm 10.2 ENO2 CHGA
17 anaplastic ependymoma 10.2 VIM EWSR1
18 small cell carcinoma of the bladder 10.2 ENO2 CHGA
19 auditory system cancer 10.2 ENO2 CHGA
20 extraskeletal ewing sarcoma 10.2 FLI1 EWSR1
21 gastric gastrinoma 10.2 ENO2 CHGA
22 ampulla of vater neoplasm 10.2 ENO2 CHGA
23 appendix carcinoid tumor 10.2 ENO2 CHGA
24 carotid body cancer 10.2 ENO2 CHGA
25 gallbladder small cell carcinoma 10.2 ENO2 CHGA
26 ureter small cell carcinoma 10.2 ENO2 CHGA
27 middle ear adenoma 10.2 ENO2 CHGA
28 nodular ganglioneuroblastoma 10.2 ENO2 CHGA
29 biphasic synovial sarcoma 10.2 VIM EWSR1
30 goblet cell carcinoid 10.2 ENO2 CHGA
31 primitive neuroectodermal tumor of the cervix uteri 10.2 VIM ENO2
32 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 CHGA
33 bednar tumor 10.2 VIM ENO2
34 gastric small cell carcinoma 10.2 ENO2 CHGA
35 sensory organ benign neoplasm 10.2 ENO2 CHGA
36 ovarian large-cell neuroendocrine carcinoma 10.2 ENO2 CHGA
37 gastric hemangioma 10.2 ENO2 CHGA
38 papillary tumor of the pineal region 10.2 VIM ENO2
39 appendix lymphoma 10.2 ENO2 CHGA
40 mesenchymal chondrosarcoma 10.2 VIM ENO2
41 subependymoma 10.2 ENO2 CHGA
42 pineocytoma 10.2 ENO2 CHGA
43 cutaneous ganglioneuroma 10.2 ENO2 CHGA
44 congenital epulis 10.2 VIM ENO2
45 epulis 10.2 VIM ENO2
46 cervix small cell carcinoma 10.2 ENO2 CHGA
47 adrenal neuroblastoma 10.2 ENO2 CHGA
48 gastrointestinal neuroendocrine tumor 10.2 ENO2 CHGA
49 carcinoid tumors, intestinal 10.2 ENO2 CHGA
50 endometrial small cell carcinoma 10.2 ENO2 CHGA

Graphical network of the top 20 diseases related to Ewing Sarcoma of Bone:



Diseases related to Ewing Sarcoma of Bone

Symptoms & Phenotypes for Ewing Sarcoma of Bone

MGI Mouse Phenotypes related to Ewing Sarcoma of Bone:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CHGA ENO2 FES FLI1 FLII LONP1

Drugs & Therapeutics for Ewing Sarcoma of Bone

Drugs for Ewing Sarcoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5 Immunosuppressive Agents Phase 2
6 Antimitotic Agents Phase 2
7 Immunologic Factors Phase 2
8 Antirheumatic Agents Phase 2
9 Tubulin Modulators Phase 2
10 topoisomerase I inhibitors Phase 2
11 Alkylating Agents Phase 2
12 Antineoplastic Agents, Immunological Phase 2
13 Angiogenesis Inhibitors Phase 2
14 Immunoglobulins Phase 2
15 Immunoglobulins, Intravenous Phase 2
16 Antibodies Phase 2
17 Antibodies, Monoclonal Phase 2
18
Etoposide Approved 33419-42-0 36462
19
Doxorubicin Approved, Investigational 23214-92-8 31703
20
Lenograstim Approved, Investigational 135968-09-1
21
Ifosfamide Approved 3778-73-2 3690
22 Antibiotics, Antitubercular
23 Etoposide phosphate
24 Anti-Bacterial Agents
25
Liposomal doxorubicin 31703
26
Isophosphamide mustard 100427

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Study of Bevacizumab (NSC 704865) Combined With Vincristine, Topotecan and Cyclophosphamide in Patients With First Recurrent Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
2 Chemotherapy-induced Necrosis in Ewing Sarcoma: Which is the Best Scoring Tool Completed NCT03968471
3 A Pilot Study of Chemotherapy Intensification by Adding Vincristine, Topotecan and Cyclophosphamide to Standard Chemotherapy Agents With an Interval Compression Schedule in Newly Diagnosed Patients With Localized Ewing Sarcoma Family of Tumors Completed NCT00618813 etoposide;ifosfamide;doxorubicin hydrochloride;cyclophosphamide;vincristine sulfate;topotecan hydrochloride

Search NIH Clinical Center for Ewing Sarcoma of Bone

Genetic Tests for Ewing Sarcoma of Bone

Anatomical Context for Ewing Sarcoma of Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Ewing Sarcoma of Bone:

19
Bone

MalaCards organs/tissues related to Ewing Sarcoma of Bone:

40
Bone

Publications for Ewing Sarcoma of Bone

Articles related to Ewing Sarcoma of Bone:

(show all 32)
# Title Authors PMID Year
1
Seeking international consensus on approaches to primary tumour treatment in Ewing sarcoma. 61
33292535 2020
2
Image-guided core needle biopsy for Ewing sarcoma of bone: a 10-year single-institution review. 61
32468104 2020
3
Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review. 61
30915559 2019
4
A nomogram to predict prognosis in Ewing sarcoma of bone. 61
30815343 2019
5
Predicting Ewing Sarcoma Treatment Outcome Using Infrared Spectroscopy and Machine Learning. 61
30893786 2019
6
Trends in incidence of Ewing sarcoma of bone in India - Evidence from the National Cancer Registry Programme (1982-2011). 61
30237969 2018
7
Comparison of the effects of local treatment strategies in non-metastatic Ewing sarcoma of bone. 61
29537323 2018
8
Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma. 61
29170560 2018
9
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1. 61
28619077 2017
10
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma. 61
27918348 2017
11
18F-FDG PET/CT as an Indicator of Survival in Ewing Sarcoma of Bone. 61
28928879 2017
12
Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy. 61
27506465 2016
13
Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. 61
25251206 2015
14
Adult intramedullary ewing sarcoma of the proximal hip. 61
25024862 2014
15
Prognostic factors for overall survival in paediatric patients with Ewing sarcoma of bone treated according to multidisciplinary protocol. 61
22484637 2012
16
Metastatic Ewing's sarcoma/PNET of kidney in 40 year old patient. 61
22466114 2012
17
Treatment results of the Ewing sarcoma of bone and prognostic factors. 61
19760772 2010
18
Second malignancy in 597 patients with ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. 61
16217253 2005
19
Ewing sarcoma: radiation dose and target volume. 61
15049023 2004
20
Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone. 61
12883251 2003
21
Extraskeletal Ewing sarcoma in a 77-year-old woman. 61
11570916 2001
22
Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. 61
10430250 1999
23
Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. 61
10064186 1999
24
The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma. 61
9698007 1998
25
Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study. 61
8443760 1993
26
Use of MR imaging to assess results of chemotherapy for Ewing sarcoma. 61
2115265 1990
27
[Ewing sarcoma originated from rib in 3-year-old child--a case report]. 61
2768950 1989
28
Adults with Ewing's sarcoma. An analysis of 16 patients at the Dana-Farber Cancer Institute. 61
3189226 1988
29
Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing sarcoma of bone. 61
6484604 1984
30
Renal displacement caused by a supradiaphragmatic, paraspinal Ewing-like sarcoma and simulating an adrenal mass. 61
7232726 1981
31
Extraskeletal Ewing sarcoma. An ultrastructural study. 61
577677 1977
32
The problem of Ewing sarcoma of bone. 61
20983234 1945

Variations for Ewing Sarcoma of Bone

Expression for Ewing Sarcoma of Bone

Search GEO for disease gene expression data for Ewing Sarcoma of Bone.

Pathways for Ewing Sarcoma of Bone

GO Terms for Ewing Sarcoma of Bone

Cellular components related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.92 VIM FLII FES CD99

Sources for Ewing Sarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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