MCID: EWN004
MIFTS: 31

Ewing Sarcoma of Bone

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Ewing Sarcoma of Bone

MalaCards integrated aliases for Ewing Sarcoma of Bone:

Name: Ewing Sarcoma of Bone 12 15
Ewing's Sarcoma/bone Peripheral Primitive Neuroectodermal Tumor 12
Localized Skeletal Ewing's Sarcoma 12
Bone Localized Ewing's Sarcoma 12
Bone Localized Ewing Sarcoma 12
Ewing's Sarcoma of Bone 12
Bone Ewing's Sarcoma 12
Bone Ewing Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3368
SNOMED-CT 67 307608006
UMLS 71 C0585474 C1333481 C1334406

Summaries for Ewing Sarcoma of Bone

Disease Ontology : 12 A peripheral primitive neuroectodermal tumor that is located in bone.

MalaCards based summary : Ewing Sarcoma of Bone, also known as ewing's sarcoma/bone peripheral primitive neuroectodermal tumor, is related to spindle cell sarcoma and reticulum cell sarcoma. An important gene associated with Ewing Sarcoma of Bone is PTPRC (Protein Tyrosine Phosphatase Receptor Type C), and among its related pathways/superpathways is Aurora B signaling. The drugs Vincristine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone and kidney.

Related Diseases for Ewing Sarcoma of Bone

Diseases related to Ewing Sarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 31.0 VIM DES
2 reticulum cell sarcoma 30.5 VIM PTPRC DES
3 ewing sarcoma 30.0 VIM PTPRC FLI1 EWSR1 ENO2 DES
4 chondrosarcoma 29.5 VIM EWSR1 ENO2
5 small cell osteogenic sarcoma 29.2 EWSR1 ENO2 CD99
6 bone sarcoma 29.1 EWSR1 ENO2 CD99
7 sarcoma 28.8 VIM PTPRC FLI1 EWSR1 ENO2 DES
8 rhabdomyosarcoma 27.6 VIM PTPRC FLI1 EWSR1 ENO2 DES
9 retroperitoneal fibrosis 10.4 VIM PTPRC
10 heart lymphoma 10.4 VIM PTPRC
11 primary hepatic neuroendocrine carcinoma 10.4 VIM CHGA
12 infantile digital fibromatosis 10.3 VIM DES
13 fibromatosis 10.3 VIM DES
14 esophageal adenoid cystic carcinoma 10.3 VIM CHGA
15 lymphangiomatosis 10.3 VIM DES
16 dendritic cell tumor 10.3 VIM PTPRC
17 benign metastasizing leiomyoma 10.3 VIM DES
18 chordoid meningioma 10.3 VIM CHGA
19 cutaneous leiomyosarcoma 10.3 VIM DES
20 glomangioma 10.3 VIM DES
21 angiolipoma 10.3 VIM DES
22 glomangiomatosis 10.3 PTPRC CHGA
23 clear cell meningioma 10.3 VIM CHGA
24 embryonal sarcoma 10.3 VIM DES
25 biphasic synovial sarcoma 10.3 VIM DES
26 mucinous cystadenocarcinoma 10.3 VIM PTPRC
27 plasmablastic lymphoma 10.3 PTPRC DES
28 chondromyxoid fibroma 10.3 VIM DES
29 pigmented villonodular synovitis 10.3 VIM PTPRC
30 sarcomatoid mesothelioma 10.2 VIM DES
31 adenosarcoma 10.2 VIM DES
32 pseudosarcomatous fibromatosis 10.2 VIM DES
33 cutaneous fibrous histiocytoma 10.2 VIM DES
34 infantile myofibromatosis 10.2 VIM DES
35 endodermal sinus tumor 10.2 VIM CHGA
36 rare tumor 10.2 EWSR1 DES
37 myoepithelial carcinoma 10.2 VIM EWSR1
38 myxoid chondrosarcoma 10.2 EWSR1 CHGA
39 spastic paraplegia 3, autosomal dominant 10.2 VIM PTPRC
40 reticulosarcoma 10.1
41 osteomyelitis 10.1
42 smooth muscle tumor 10.1 VIM DES
43 pulmonary blastoma 10.1 DES CHGA
44 budd-chiari syndrome 10.1 VIM PTPRC CHGA
45 monophasic synovial sarcoma 10.1 VIM CD99
46 pulmonary vein stenosis 10.1 DES CD99
47 rhabdoid tumor predisposition syndrome 1 10.1 VIM PTPRC DES
48 benign giant cell tumor 10.1 VIM PTPRC DES
49 angiomyolipoma 10.1 VIM PTPRC DES
50 parachordoma 10.1 VIM DES CHGA

Graphical network of the top 20 diseases related to Ewing Sarcoma of Bone:



Diseases related to Ewing Sarcoma of Bone

Symptoms & Phenotypes for Ewing Sarcoma of Bone

Drugs & Therapeutics for Ewing Sarcoma of Bone

Drugs for Ewing Sarcoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
6
Lenograstim Approved, Investigational Phase 2 135968-09-1
7
Ifosfamide Approved Phase 2 3778-73-2 3690
8
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
9 Immunoglobulins Phase 2
10 Antibodies Phase 2
11 Angiogenesis Inhibitors Phase 2
12 Antibodies, Monoclonal Phase 2
13 Immunosuppressive Agents Phase 2
14 Immunoglobulins, Intravenous Phase 2
15 Immunologic Factors Phase 2
16 Tubulin Modulators Phase 2
17 Antirheumatic Agents Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Alkylating Agents Phase 2
20 topoisomerase I inhibitors Phase 2
21 Antimitotic Agents Phase 2
22 Cardiotonic Agents Phase 2
23 razoxane Phase 2
24
Liposomal doxorubicin Phase 2 31703
25
Isophosphamide mustard Phase 2 0
26 Anti-Bacterial Agents Phase 2
27 Antibiotics, Antitubercular Phase 2
28 Protective Agents Phase 2
29
Etoposide Approved 33419-42-0 36462
30 Etoposide phosphate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Study of Bevacizumab (NSC 704865) Combined With Vincristine, Topotecan and Cyclophosphamide in Patients With First Recurrent Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
2 A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
3 Phase II Trial of Neoadjuvant Dose-Dense Doxorubicin, Ifosfamide, and Irinotecan (CPT-11) for Advanced Soft Tissue and Recurrent Bone Sarcomas Terminated NCT00544778 Phase 2 dexrazoxane hydrochloride;doxorubicin hydrochloride;ifosfamide;irinotecan hydrochloride
4 Chemotherapy-induced Necrosis in Ewing Sarcoma: Which is the Best Scoring Tool Completed NCT03968471
5 A Pilot Study of Chemotherapy Intensification by Adding Vincristine, Topotecan and Cyclophosphamide to Standard Chemotherapy Agents With an Interval Compression Schedule in Newly Diagnosed Patients With Localized Ewing Sarcoma Family of Tumors Completed NCT00618813 etoposide;ifosfamide;doxorubicin hydrochloride;cyclophosphamide;vincristine sulfate;topotecan hydrochloride

Search NIH Clinical Center for Ewing Sarcoma of Bone

Genetic Tests for Ewing Sarcoma of Bone

Anatomical Context for Ewing Sarcoma of Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Ewing Sarcoma of Bone:

19
Bone

MalaCards organs/tissues related to Ewing Sarcoma of Bone:

40
Bone, Kidney

Publications for Ewing Sarcoma of Bone

Articles related to Ewing Sarcoma of Bone:

(show all 31)
# Title Authors PMID Year
1
Image-guided core needle biopsy for Ewing sarcoma of bone: a 10-year single-institution review. 61
32468104 2020
2
Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review. 61
30915559 2019
3
A nomogram to predict prognosis in Ewing sarcoma of bone. 61
30815343 2019
4
Predicting Ewing Sarcoma Treatment Outcome Using Infrared Spectroscopy and Machine Learning. 61
30893786 2019
5
Trends in incidence of Ewing sarcoma of bone in India - Evidence from the National Cancer Registry Programme (1982-2011). 61
30237969 2018
6
Comparison of the effects of local treatment strategies in non-metastatic Ewing sarcoma of bone. 61
29537323 2018
7
Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma. 61
29170560 2018
8
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1. 61
28619077 2017
9
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma. 61
27918348 2017
10
18F-FDG PET/CT as an Indicator of Survival in Ewing Sarcoma of Bone. 61
28928879 2017
11
Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy. 61
27506465 2016
12
Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. 61
25251206 2015
13
Adult intramedullary ewing sarcoma of the proximal hip. 61
25024862 2014
14
Prognostic factors for overall survival in paediatric patients with Ewing sarcoma of bone treated according to multidisciplinary protocol. 61
22484637 2012
15
Metastatic Ewing's sarcoma/PNET of kidney in 40 year old patient. 61
22466114 2012
16
Treatment results of the Ewing sarcoma of bone and prognostic factors. 61
19760772 2010
17
Second malignancy in 597 patients with ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. 61
16217253 2005
18
Ewing sarcoma: radiation dose and target volume. 61
15049023 2004
19
Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone. 61
12883251 2003
20
Extraskeletal Ewing sarcoma in a 77-year-old woman. 61
11570916 2001
21
Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. 61
10430250 1999
22
Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. 61
10064186 1999
23
The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma. 61
9698007 1998
24
Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study. 61
8443760 1993
25
Use of MR imaging to assess results of chemotherapy for Ewing sarcoma. 61
2115265 1990
26
[Ewing sarcoma originated from rib in 3-year-old child--a case report]. 61
2768950 1989
27
Adults with Ewing's sarcoma. An analysis of 16 patients at the Dana-Farber Cancer Institute. 61
3189226 1988
28
Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing sarcoma of bone. 61
6484604 1984
29
Renal displacement caused by a supradiaphragmatic, paraspinal Ewing-like sarcoma and simulating an adrenal mass. 61
7232726 1981
30
Extraskeletal Ewing sarcoma. An ultrastructural study. 61
577677 1977
31
The problem of Ewing sarcoma of bone. 61
20983234 1945

Variations for Ewing Sarcoma of Bone

Expression for Ewing Sarcoma of Bone

Search GEO for disease gene expression data for Ewing Sarcoma of Bone.

Pathways for Ewing Sarcoma of Bone

Pathways related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.28 VIM DES

GO Terms for Ewing Sarcoma of Bone

Cellular components related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.8 VIM MDN1 DES

Biological processes related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.96 VIM DES
2 intermediate filament organization GO:0045109 8.62 VIM DES

Sources for Ewing Sarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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