MCID: EWN004
MIFTS: 40

Ewing Sarcoma of Bone

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Ewing Sarcoma of Bone

MalaCards integrated aliases for Ewing Sarcoma of Bone:

Name: Ewing Sarcoma of Bone 12
Bone Ewing's Sarcoma 12 15
Ewing's Sarcoma/bone Peripheral Primitive Neuroectodermal Tumor 12
Localized Skeletal Ewing's Sarcoma 12
Bone Localized Ewing's Sarcoma 12
Bone Localized Ewing Sarcoma 12
Ewing's Sarcoma of Bone 12
Bone Ewing Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3368
UMLS 72 C0585474 C1333481 C1334406

Summaries for Ewing Sarcoma of Bone

Disease Ontology : 12 A peripheral primitive neuroectodermal tumor that is located in bone.

MalaCards based summary : Ewing Sarcoma of Bone, also known as bone ewing's sarcoma, is related to reticulum cell sarcoma and small cell osteogenic sarcoma. An important gene associated with Ewing Sarcoma of Bone is PTPRC (Protein Tyrosine Phosphatase Receptor Type C), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Human T-cell leukemia virus 1 infection. The drugs Cyclophosphamide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and kidney, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Ewing Sarcoma of Bone

Diseases related to Ewing Sarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 31.1 VIM PTPRC DES
2 small cell osteogenic sarcoma 31.0 EWSR1 ENO2
3 giant cell tumor 30.8 VIM PTPRC DES
4 sarcoma 30.0 VIM PDGFB FES EWSR1
5 rhabdomyosarcoma 29.9 VIM PTPRC MYCN EWSR1 ENO2 DES
6 ewing sarcoma 29.6 VIM PTPRC PDGFB MYCN MYC EWSR1
7 infantile digital fibromatosis 10.8 VIM DES
8 lymphangiomatosis 10.8 VIM DES
9 primary hepatic neuroendocrine carcinoma 10.8 VIM CHGA
10 retroperitoneal fibrosis 10.8 VIM PTPRC
11 angiolipoma 10.7 VIM DES
12 multicentric reticulohistiocytosis 10.7 VIM PTPRC
13 syringocystadenoma papilliferum 10.7 VIM DES
14 urinary bladder small cell neuroendocrine carcinoma 10.7 ENO2 CHGA
15 parachordoma 10.7 VIM DES
16 chordoid meningioma 10.7 VIM CHGA
17 spindle cell lipoma 10.7 VIM DES
18 papillary tumor of the pineal region 10.7 VIM ENO2
19 auditory system cancer 10.7 ENO2 CHGA
20 small cell carcinoma of the bladder 10.7 ENO2 CHGA
21 benign metastasizing leiomyoma 10.7 VIM DES
22 malignant ectomesenchymoma 10.7 ENO2 DES
23 ectomesenchymoma 10.7 ENO2 DES
24 epithelioid malignant peripheral nerve sheath tumor 10.7 ENO2 CHGA
25 goblet cell carcinoid 10.6 ENO2 CHGA
26 hodgkin's lymphoma, mixed cellularity 10.6 PTPRC B3GAT1
27 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.6 PTPRC B3GAT1
28 atypical follicular adenoma 10.6 ENO2 CHGA
29 gallbladder small cell carcinoma 10.6 ENO2 CHGA
30 clear cell ependymoma 10.6 VIM ENO2
31 pulmonary large cell neuroendocrine carcinoma 10.6 ENO2 CHGA
32 lung oat cell carcinoma 10.6 ENO2 CHGA
33 endometrial small cell carcinoma 10.6 PTPRC ENO2
34 clear cell meningioma 10.6 VIM CHGA
35 vulvar sarcoma 10.6 PTPRC EWSR1
36 conventional fibrosarcoma 10.6 PTPRC ENO2
37 astroblastoma 10.6 VIM ENO2
38 malignant fibroxanthoma 10.6 VIM PTPRC DES
39 rhabdoid tumor predisposition syndrome 1 10.6 VIM PTPRC DES
40 adrenal neuroblastoma 10.6 MYCN ENO2
41 small cell carcinoma 10.6 PTPRC ENO2 CHGA
42 biphasic synovial sarcoma 10.6 VIM EWSR1 DES
43 fibrous histiocytoma 10.6 VIM EWSR1 DES
44 epulis 10.6 VIM ENO2 DES
45 epithelioid leiomyosarcoma 10.6 VIM ENO2 DES
46 leiomyosarcoma 10.6 VIM ENO2 DES
47 myoepithelioma 10.6 VIM PTPRC EWSR1
48 ossifying fibromyxoid tumor 10.6 VIM ENO2 DES
49 granulosa cell tumor of the ovary 10.5 VIM ENO2 CHGA
50 glomus tumor 10.5 VIM ENO2 DES

Graphical network of the top 20 diseases related to Ewing Sarcoma of Bone:



Diseases related to Ewing Sarcoma of Bone

Symptoms & Phenotypes for Ewing Sarcoma of Bone

MGI Mouse Phenotypes related to Ewing Sarcoma of Bone:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 CHAT CHGA ENO2 ETS1 FES LONP1
2 cardiovascular system MP:0005385 10.1 CHAT CHGA DES ETS1 FES MYB
3 mortality/aging MP:0010768 10.07 B3GAT1 CHAT CHGA DES ETS1 FES
4 homeostasis/metabolism MP:0005376 10.06 CHAT CHGA DES ETS1 FES LONP1
5 muscle MP:0005369 9.76 CHAT CHGA DES FES MYC MYCN
6 nervous system MP:0003631 9.7 B3GAT1 CHAT CHGA ENO2 FES LONP1
7 reproductive system MP:0005389 9.23 B3GAT1 CHAT CHGA FES MYC MYCN

Drugs & Therapeutics for Ewing Sarcoma of Bone

Drugs for Ewing Sarcoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
5
Ifosfamide Approved Phase 2 3778-73-2 3690
6
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
7
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
8
Lenograstim Approved, Investigational Phase 2 135968-09-1
9
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
10 Angiogenesis Inhibitors Phase 2
11 Antineoplastic Agents, Phytogenic Phase 2
12 Antibodies Phase 2
13 Angiogenesis Modulating Agents Phase 2
14 Tubulin Modulators Phase 2
15 Immunologic Factors Phase 2
16 Antineoplastic Agents, Immunological Phase 2
17 Immunosuppressive Agents Phase 2
18 Immunoglobulins Phase 2
19 Antibodies, Monoclonal Phase 2
20 Antirheumatic Agents Phase 2
21 razoxane Phase 2
22 Alkylating Agents Phase 2
23 Cardiotonic Agents Phase 2
24
Liposomal doxorubicin Phase 2 31703
25 Anti-Bacterial Agents Phase 2
26 Antibiotics, Antitubercular Phase 2
27 Protective Agents Phase 2
28 Topoisomerase Inhibitors Phase 2
29 topoisomerase I inhibitors Phase 2
30
Isophosphamide mustard Phase 2 0
31 Antineoplastic Agents, Alkylating Phase 2
32 Antimitotic Agents Phase 2
33
Etoposide Approved 33419-42-0 36462
34 Etoposide phosphate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Study of Bevacizumab (NSC 704865) Combined With Vincristine, Topotecan and Cyclophosphamide in Patients With First Recurrent Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
2 A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
3 Phase II Trial of Neoadjuvant Dose-Dense Doxorubicin, Ifosfamide, and Irinotecan (CPT-11) for Advanced Soft Tissue and Recurrent Bone Sarcomas Terminated NCT00544778 Phase 2 dexrazoxane hydrochloride;doxorubicin hydrochloride;ifosfamide;irinotecan hydrochloride
4 A Pilot Study of Chemotherapy Intensification by Adding Vincristine, Topotecan and Cyclophosphamide to Standard Chemotherapy Agents With an Interval Compression Schedule in Newly Diagnosed Patients With Localized Ewing Sarcoma Family of Tumors Completed NCT00618813 etoposide;ifosfamide;doxorubicin hydrochloride;cyclophosphamide;vincristine sulfate;topotecan hydrochloride
5 Chemotherapy-induced Necrosis in Ewing Sarcoma: Which is the Best Scoring Tool Recruiting NCT03968471

Search NIH Clinical Center for Ewing Sarcoma of Bone

Genetic Tests for Ewing Sarcoma of Bone

Anatomical Context for Ewing Sarcoma of Bone

MalaCards organs/tissues related to Ewing Sarcoma of Bone:

41
Bone, Brain, Kidney, Bone Marrow, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Ewing Sarcoma of Bone:

19
Bone

Publications for Ewing Sarcoma of Bone

Articles related to Ewing Sarcoma of Bone:

(show all 41)
# Title Authors PMID Year
1
A nomogram to predict prognosis in Ewing sarcoma of bone. 38
30815343 2019
2
Predicting Ewing Sarcoma Treatment Outcome Using Infrared Spectroscopy and Machine Learning. 38
30893786 2019
3
Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review. 38
30915559 2019
4
Trends in incidence of Ewing sarcoma of bone in India - Evidence from the National Cancer Registry Programme (1982-2011). 38
30237969 2018
5
Comparison of the effects of local treatment strategies in non-metastatic Ewing sarcoma of bone. 38
29537323 2018
6
Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma. 38
29170560 2018
7
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1. 38
28619077 2017
8
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma. 38
27918348 2017
9
18F-FDG PET/CT as an Indicator of Survival in Ewing Sarcoma of Bone. 38
28928879 2017
10
Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy. 38
27506465 2016
11
Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. 38
25251206 2015
12
Adult intramedullary ewing sarcoma of the proximal hip. 38
25024862 2014
13
Bee-sting, a non-resolving wound and a progressive mass over the right eye preceding the ultimate diagnosis of frontal bone Ewing's sarcoma. 38
22761215 2012
14
Risk adapted chemotherapy for localised Ewing's sarcoma of bone: the French EW93 study. 38
22516209 2012
15
Prognostic factors for overall survival in paediatric patients with Ewing sarcoma of bone treated according to multidisciplinary protocol. 38
22484637 2012
16
Metastatic Ewing's sarcoma/PNET of kidney in 40 year old patient. 38
22466114 2012
17
Treatment results of the Ewing sarcoma of bone and prognostic factors. 38
19760772 2010
18
Second malignancy in 597 patients with ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. 38
16217253 2005
19
Ewing sarcoma: radiation dose and target volume. 38
15049023 2004
20
Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone. 38
12883251 2003
21
Extraskeletal Ewing sarcoma in a 77-year-old woman. 38
11570916 2001
22
Primary petrous bone Ewing's sarcoma. 38
10889890 2000
23
Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. 38
10430250 1999
24
Brain metastases in musculoskeletal sarcomas. 38
10379335 1999
25
Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. 38
10064186 1999
26
The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma. 38
9698007 1998
27
Primary Ewing's sarcoma of the temporal bone with intracranial, extracranial and intraorbital extension. Case report. 38
9226674 1997
28
[Comprehensive therapy of localized bone marrow sarcoma in children]. 38
9381696 1997
29
Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study. 38
8443760 1993
30
Use of MR imaging to assess results of chemotherapy for Ewing sarcoma. 38
2115265 1990
31
[Ewing sarcoma originated from rib in 3-year-old child--a case report]. 38
2768950 1989
32
Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing sarcoma of bone. 38
6484604 1984
33
Renal displacement caused by a supradiaphragmatic, paraspinal Ewing-like sarcoma and simulating an adrenal mass. 38
7232726 1981
34
Extraskeletal Ewing sarcoma. An ultrastructural study. 38
577677 1977
35
Peripheral lymphocyte count and suppopulations of T and B lymphocytes in benign and malignant diseases. 38
300179 1977
36
[Primary reticuloblastomas of the bone. Ewing's sarcoma and reticulosarcoma (Parker and Jackson). Considerations on their histopathological and radiological diagnosis]. 38
5338164 1965
37
[Anatomical and clinical study of 17 cases of reticulosarcoma of bone; Ewing's sarcoma; treatment; results]. 38
13182313 1954
38
Endothelioma of bone; Ewing's sarcoma. 38
18889550 1948
39
Endothelioma of bone; Ewing's sarcoma. 38
18108716 1948
40
The problem of Ewing sarcoma of bone. 38
20983234 1945
41
Diffuse Endothelioma of Bone: Ewing's Sarcoma. 38
17866597 1931

Variations for Ewing Sarcoma of Bone

Expression for Ewing Sarcoma of Bone

Search GEO for disease gene expression data for Ewing Sarcoma of Bone.

Pathways for Ewing Sarcoma of Bone

GO Terms for Ewing Sarcoma of Bone

Biological processes related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 PDGFB MYCN MYC MYB ETS1
2 positive regulation of smooth muscle cell migration GO:0014911 9.46 PDGFB MYC
3 intermediate filament organization GO:0045109 9.43 VIM DES
4 positive regulation of glial cell proliferation GO:0060252 9.4 MYC MYB
5 positive regulation of gene expression GO:0010628 9.35 VIM PDGFB MYCN MYC ETS1
6 response to wounding GO:0009611 9.33 PDGFB MYC ETS1
7 positive regulation of DNA biosynthetic process GO:2000573 9.32 PDGFB MYC
8 hypothalamus development GO:0021854 9.26 MYC ETS1
9 positive regulation of smooth muscle cell proliferation GO:0048661 8.8 PDGFB MYC MYB

Sources for Ewing Sarcoma of Bone

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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
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69 SNOMED-CT via HPO
70 TGDB
71 Tocris
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73 UMLS via Orphanet
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