MCID: EWN004
MIFTS: 33

Ewing Sarcoma of Bone

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Ewing Sarcoma of Bone

MalaCards integrated aliases for Ewing Sarcoma of Bone:

Name: Ewing Sarcoma of Bone 12
Bone Ewing's Sarcoma 12 15
Ewing's Sarcoma/bone Peripheral Primitive Neuroectodermal Tumor 12
Localized Skeletal Ewing's Sarcoma 12
Bone Localized Ewing's Sarcoma 12
Bone Localized Ewing Sarcoma 12
Ewing's Sarcoma of Bone 12
Bone Ewing Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3368
UMLS 71 C0585474 C1333481 C1334406

Summaries for Ewing Sarcoma of Bone

Disease Ontology : 12 A peripheral primitive neuroectodermal tumor that is located in bone.

MalaCards based summary : Ewing Sarcoma of Bone, also known as bone ewing's sarcoma, is related to spindle cell sarcoma and ewing sarcoma. An important gene associated with Ewing Sarcoma of Bone is PTPRC (Protein Tyrosine Phosphatase Receptor Type C), and among its related pathways/superpathways are Striated Muscle Contraction and Aurora B signaling. The drugs Cyclophosphamide and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and eye, and related phenotype is Reduced mammosphere formation.

Related Diseases for Ewing Sarcoma of Bone

Diseases related to Ewing Sarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.6 VIM DES
2 ewing sarcoma 30.5 VIM PTPRC EWSR1 DES CHGA CD99
3 sarcoma 30.1 VIM PTPRC EWSR1
4 reticulum cell sarcoma 29.8 VIM PTPRC DES
5 small cell osteogenic sarcoma 29.7 EWSR1 CD99
6 giant cell tumor 29.6 VIM PTPRC DES
7 rhabdomyosarcoma 28.3 VIM PTPRC EWSR1 DES CD99
8 retroperitoneal fibrosis 10.2 VIM PTPRC
9 heart lymphoma 10.2 VIM PTPRC
10 dendritic cell tumor 10.2 VIM PTPRC
11 primary hepatic neuroendocrine carcinoma 10.2 VIM CHGA
12 esophageal adenoid cystic carcinoma 10.2 VIM CHGA
13 mucinous cystadenocarcinoma 10.1 VIM PTPRC
14 chordoid meningioma 10.1 VIM CHGA
15 cystadenocarcinoma 10.1 VIM PTPRC
16 neuroendocrine carcinoma 10.1 PTPRC CHGA
17 pancreas lymphoma 10.1 PTPRC CHGA
18 granulosa cell tumor of the ovary 10.1 VIM CHGA
19 osteomyelitis 10.1
20 reticulosarcoma 10.1
21 cerebellopontine angle primitive neuroectodermal 10.1 PTPRC CD99
22 clear cell meningioma 10.1 VIM CHGA
23 chordoma 10.1 VIM DES
24 endometrial small cell carcinoma 10.1 PTPRC CHGA
25 small cell carcinoma 10.1 PTPRC CHGA
26 appendix lymphoma 10.1 PTPRC CHGA
27 infantile digital fibromatosis 10.1 VIM DES
28 fibromatosis 10.1 VIM DES
29 prostate neuroendocrine neoplasm 10.1 PTPRC CHGA
30 glomangiomatosis 10.1 PTPRC CHGA
31 lymphangiomatosis 10.1 VIM DES
32 mediastinal cancer 10.1 PTPRC CHGA
33 mesenchymal chondrosarcoma 10.1 VIM DES
34 congenital epulis 10.1 VIM DES
35 epulis 10.1 VIM DES
36 benign metastasizing leiomyoma 10.1 VIM DES
37 cutaneous leiomyosarcoma 10.1 VIM DES
38 angiolipoma 10.1 VIM DES
39 glomangioma 10.1 VIM DES
40 embryonal sarcoma 10.1 VIM DES
41 endodermal sinus tumor 10.1 VIM CHGA
42 subependymal giant cell astrocytoma 10.1 VIM CHGA
43 ossifying fibromyxoid tumor 10.1 VIM DES
44 chondromyxoid fibroma 10.0 VIM DES
45 plasmablastic lymphoma 10.0 PTPRC DES
46 adenomatoid tumor 10.0 VIM DES
47 adrenal cortical carcinoma 10.0 VIM CHGA
48 syringoma 10.0 VIM DES
49 cystic nephroma 10.0 VIM DES
50 medulloepithelioma 10.0 VIM DES

Graphical network of the top 20 diseases related to Ewing Sarcoma of Bone:



Diseases related to Ewing Sarcoma of Bone

Symptoms & Phenotypes for Ewing Sarcoma of Bone

GenomeRNAi Phenotypes related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 CHGA DES PTPRC VIM

Drugs & Therapeutics for Ewing Sarcoma of Bone

Drugs for Ewing Sarcoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
4
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
5
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
6
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
7
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
8
Ifosfamide Approved Phase 2 3778-73-2 3690
9
Lenograstim Approved, Investigational Phase 2 135968-09-1
10 Antibodies, Monoclonal Phase 2
11 Antineoplastic Agents, Immunological Phase 2
12 Angiogenesis Inhibitors Phase 2
13 Immunologic Factors Phase 2
14 Antirheumatic Agents Phase 2
15 Immunosuppressive Agents Phase 2
16 Antibodies Phase 2
17 Immunoglobulins Phase 2
18 Alkylating Agents Phase 2
19 topoisomerase I inhibitors Phase 2
20 Topoisomerase Inhibitors Phase 2
21 Antimitotic Agents Phase 2
22 Anti-Bacterial Agents Phase 2
23
Isophosphamide mustard Phase 2 0
24 Antibiotics, Antitubercular Phase 2
25 razoxane Phase 2
26
Liposomal doxorubicin Phase 2 31703
27 Protective Agents Phase 2
28
Etoposide Approved 33419-42-0 36462
29 Etoposide phosphate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Study of Bevacizumab (NSC 704865) Combined With Vincristine, Topotecan and Cyclophosphamide in Patients With First Recurrent Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
2 A Randomized Phase II, Placebo-controlled, Multicenter Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
3 Phase II Trial of Neoadjuvant Dose-Dense Doxorubicin, Ifosfamide, and Irinotecan (CPT-11) for Advanced Soft Tissue and Recurrent Bone Sarcomas Terminated NCT00544778 Phase 2 dexrazoxane hydrochloride;doxorubicin hydrochloride;ifosfamide;irinotecan hydrochloride
4 A Pilot Study of Chemotherapy Intensification by Adding Vincristine, Topotecan and Cyclophosphamide to Standard Chemotherapy Agents With an Interval Compression Schedule in Newly Diagnosed Patients With Localized Ewing Sarcoma Family of Tumors Completed NCT00618813 etoposide;ifosfamide;doxorubicin hydrochloride;cyclophosphamide;vincristine sulfate;topotecan hydrochloride
5 Chemotherapy-induced Necrosis in Ewing Sarcoma: Which is the Best Scoring Tool Recruiting NCT03968471

Search NIH Clinical Center for Ewing Sarcoma of Bone

Genetic Tests for Ewing Sarcoma of Bone

Anatomical Context for Ewing Sarcoma of Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Ewing Sarcoma of Bone:

19
Bone

MalaCards organs/tissues related to Ewing Sarcoma of Bone:

40
Bone, Bone Marrow, Eye, Brain, Kidney, Heart, Smooth Muscle

Publications for Ewing Sarcoma of Bone

Articles related to Ewing Sarcoma of Bone:

(show all 41)
# Title Authors PMID Year
1
Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review. 61
30915559 2019
2
A nomogram to predict prognosis in Ewing sarcoma of bone. 61
30815343 2019
3
Predicting Ewing Sarcoma Treatment Outcome Using Infrared Spectroscopy and Machine Learning. 61
30893786 2019
4
Trends in incidence of Ewing sarcoma of bone in India - Evidence from the National Cancer Registry Programme (1982-2011). 61
30237969 2018
5
Comparison of the effects of local treatment strategies in non-metastatic Ewing sarcoma of bone. 61
29537323 2018
6
Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma. 61
29170560 2018
7
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1. 61
28619077 2017
8
18F-FDG PET/CT as an Indicator of Survival in Ewing Sarcoma of Bone. 61
28928879 2017
9
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma. 61
27918348 2017
10
Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy. 61
27506465 2016
11
Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. 61
25251206 2015
12
Adult intramedullary ewing sarcoma of the proximal hip. 61
25024862 2014
13
Bee-sting, a non-resolving wound and a progressive mass over the right eye preceding the ultimate diagnosis of frontal bone Ewing's sarcoma. 61
22761215 2012
14
Risk adapted chemotherapy for localised Ewing's sarcoma of bone: the French EW93 study. 61
22516209 2012
15
Prognostic factors for overall survival in paediatric patients with Ewing sarcoma of bone treated according to multidisciplinary protocol. 61
22484637 2012
16
Metastatic Ewing's sarcoma/PNET of kidney in 40 year old patient. 61
22466114 2012
17
Treatment results of the Ewing sarcoma of bone and prognostic factors. 61
19760772 2010
18
Second malignancy in 597 patients with ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. 61
16217253 2005
19
Ewing sarcoma: radiation dose and target volume. 61
15049023 2004
20
Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone. 61
12883251 2003
21
Extraskeletal Ewing sarcoma in a 77-year-old woman. 61
11570916 2001
22
Primary petrous bone Ewing's sarcoma. 61
10889890 2000
23
Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. 61
10430250 1999
24
Brain metastases in musculoskeletal sarcomas. 61
10379335 1999
25
Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. 61
10064186 1999
26
The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing sarcoma. 61
9698007 1998
27
[Comprehensive therapy of localized bone marrow sarcoma in children]. 61
9381696 1997
28
Primary Ewing's sarcoma of the temporal bone with intracranial, extracranial and intraorbital extension. Case report. 61
9226674 1997
29
Ewing sarcoma of bone in infants and toddlers. A clinicopathologic report from the Intergroup Ewing's Study. 61
8443760 1993
30
Use of MR imaging to assess results of chemotherapy for Ewing sarcoma. 61
2115265 1990
31
[Ewing sarcoma originated from rib in 3-year-old child--a case report]. 61
2768950 1989
32
Roentgenographic-pathologic correlation of diffuse sclerosis in Ewing sarcoma of bone. 61
6484604 1984
33
Renal displacement caused by a supradiaphragmatic, paraspinal Ewing-like sarcoma and simulating an adrenal mass. 61
7232726 1981
34
Extraskeletal Ewing sarcoma. An ultrastructural study. 61
577677 1977
35
Peripheral lymphocyte count and suppopulations of T and B lymphocytes in benign and malignant diseases. 61
300179 1977
36
[Primary reticuloblastomas of the bone. Ewing's sarcoma and reticulosarcoma (Parker and Jackson). Considerations on their histopathological and radiological diagnosis]. 61
5338164 1965
37
[Anatomical and clinical study of 17 cases of reticulosarcoma of bone; Ewing's sarcoma; treatment; results]. 61
13182313 1954
38
Endothelioma of bone; Ewing's sarcoma. 61
18889550 1948
39
Endothelioma of bone; Ewing's sarcoma. 61
18108716 1948
40
The problem of Ewing sarcoma of bone. 61
20983234 1945
41
Diffuse Endothelioma of Bone: Ewing's Sarcoma. 61
17866597 1931

Variations for Ewing Sarcoma of Bone

Expression for Ewing Sarcoma of Bone

Search GEO for disease gene expression data for Ewing Sarcoma of Bone.

Pathways for Ewing Sarcoma of Bone

Pathways related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 VIM DES
2
Show member pathways
10.28 VIM DES

GO Terms for Ewing Sarcoma of Bone

Cellular components related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.13 VIM PTPRC CD99
2 intermediate filament cytoskeleton GO:0045111 8.62 VIM DES

Biological processes related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.96 VIM DES
2 intermediate filament organization GO:0045109 8.62 VIM DES

Molecular functions related to Ewing Sarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 VIM DES

Sources for Ewing Sarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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