MCID: EWN002
MIFTS: 53

Ewing's Family of Tumors

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Ewing's Family of Tumors

MalaCards integrated aliases for Ewing's Family of Tumors:

Name: Ewing's Family of Tumors 53
Neuroectodermal Tumor, Primitive 73
Primitive Neuroectodermal Tumor 53
Ewing Family of Tumors 53

Classifications:



External Ids:

UMLS 73 C0206663

Summaries for Ewing's Family of Tumors

MalaCards based summary : Ewing's Family of Tumors, also known as neuroectodermal tumor, primitive, is related to ewing sarcoma and extraskeletal ewing sarcoma. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are GPCR Pathway and PEDF Induced Signaling. The drugs Racepinephrine and Cortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ewing's Family of Tumors

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 30.5 CDK4 CDKN2A CSF3 EWSR1 FAS FLI1
2 extraskeletal ewing sarcoma 30.5 EWSR1 FLI1
3 neurofibroma 30.2 CDKN2A KIT KITLG
4 gastrointestinal stromal tumor 30.2 CDKN2A KIT KITLG
5 glioblastoma 29.8 CDK4 CDKN2A CDKN2B ERBB2 MTOR RB1
6 glioblastoma multiforme 29.8 CDK4 CDKN2A ERBB2 MTOR RB1
7 squamous cell carcinoma 29.7 CDKN2A ERBB2 FAS RB1
8 leukemia, acute myeloid 29.4 CDKN2B CSF3 KIT KITLG MTOR
9 myelodysplastic syndrome 29.1 CDKN2B CSF3 EPO EPOR FAS KIT
10 sarcoma 29.0 CDK4 EWSR1 FLI1 KIT MTOR RB1
11 supratentorial primitive neuroectodermal tumor 12.6
12 cerebral primitive neuroectodermal tumor 12.6
13 primitive neuroectodermal tumor of the cervix uteri 12.5
14 intracranial primitive neuroectodermal tumor 12.4
15 supratentorial primitive neuroectodermal tumors, childhood 12.3
16 primitive neuroectodermal tumor of the corpus uteri 12.3
17 medulloblastoma 12.3
18 bone ewing's sarcoma 11.9
19 pineoblastoma 11.8
20 spinal cord primitive neuroectodermal neoplasm 11.7
21 extraosseous ewing's sarcoma 11.7
22 cerebellopontine angle primitive neuroectodermal 11.7
23 bone peripheral neuroepithelioma 11.6
24 atypical teratoid rhabdoid tumor 11.6
25 askin's tumor 11.6
26 ependymoblastoma 11.6
27 rhabdoid tumor predisposition syndrome 1 11.5
28 adult central nervous system primitive neuroectodermal neoplasm 11.3
29 childhood central nervous system primitive neuroectodermal neoplasm 11.3
30 rhabdoid tumor predisposition syndrome 2 11.3
31 pineoblastoma, childhood 11.3
32 teratoma 10.5
33 rhabdoid cancer 10.5
34 spindle cell sarcoma 10.4
35 germ cells tumors 10.4
36 retinoblastoma 10.4
37 cystic teratoma 10.3
38 breast papillomatosis 10.2 CDKN2A ERBB2
39 cellular myxoid liposarcoma 10.2 CDK4 EWSR1
40 leukemia 10.2
41 lymphoma 10.2
42 childhood medulloblastoma 10.2
43 glioma 10.2
44 heparin-induced thrombocytopenia 10.2
45 infiltrating angiolipoma 10.2 CDK4 CDKN2A
46 fallopian tube endometrioid adenocarcinoma 10.2 CDKN2A ERBB2
47 tenosynovial giant cell tumor 10.2 CDKN2A CDKN2B
48 scrotal carcinoma 10.2 CDKN2A CDKN2B
49 cornea cancer 10.2 CDK4 CDKN2A
50 vulval paget's disease 10.2 CDKN2A ERBB2

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to Ewing's Family of Tumors

Symptoms & Phenotypes for Ewing's Family of Tumors

GenomeRNAi Phenotypes related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.16 KIT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.16 EWSR1 MTOR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.16 MTOR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.16 CDK4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.16 EWSR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.16 EWSR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.16 EWSR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.16 EWSR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.16 EWSR1 KIT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.16 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.16 MTOR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.16 EWSR1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.16 KIT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.16 EWSR1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.16 CDK4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.16 KIT
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.16 CDK4 EWSR1 KIT MTOR
18 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.16 CDK4
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.16 EWSR1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.16 MTOR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.16 EWSR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.16 CDK4 KIT MTOR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.16 KIT
24 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.16 EWSR1 KIT
25 Decreased substrate adherent cell growth GR00193-A-1 9.7 KIT
26 Decreased substrate adherent cell growth GR00193-A-2 9.7 CDK4 KIT MTOR
27 Decreased substrate adherent cell growth GR00193-A-3 9.7 CDK4
28 Decreased substrate adherent cell growth GR00193-A-4 9.7 CDK4 KIT
29 Increased transferrin (TF) endocytosis GR00363-A 9.32 CDK4 CDKN2A CDKN2B EPO EPOR ERBB2

MGI Mouse Phenotypes related to Ewing's Family of Tumors:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.38 CDK4 CDKN2A CDKN2B EPO EPOR ERBB2
2 cardiovascular system MP:0005385 10.35 CDK4 CDKN2A EPO EPOR ERBB2 FAS
3 hematopoietic system MP:0005397 10.35 CDK4 CDKN2A CDKN2B CSF3 EPO EPOR
4 immune system MP:0005387 10.33 CDK4 CDKN2A CDKN2B CSF3 EPO EPOR
5 homeostasis/metabolism MP:0005376 10.3 CDK4 CDKN2A CDKN2B EPO EPOR ERBB2
6 embryo MP:0005380 10.29 CDK4 CDKN2A EPO EPOR ERBB2 FLI1
7 endocrine/exocrine gland MP:0005379 10.28 CDK4 CDKN2A CDKN2B ERBB2 FAS FLI1
8 growth/size/body region MP:0005378 10.27 CDK4 CDKN2A EPOR ERBB2 FAS FLI1
9 mortality/aging MP:0010768 10.27 CDK4 CDKN2A CDKN2B EPO EPOR ERBB2
10 integument MP:0010771 10.24 CDK4 CDKN2A CDKN2B CSF3 EPO ERBB2
11 liver/biliary system MP:0005370 10.16 CDK4 CDKN2A EPO EPOR FAS FLI1
12 digestive/alimentary MP:0005381 10.14 CDK4 CDKN2A ERBB2 FAS KIT KITLG
13 nervous system MP:0003631 10.13 CDK4 CDKN2A EPOR ERBB2 FAS FLI1
14 neoplasm MP:0002006 10.11 CDK4 CDKN2A CDKN2B ERBB2 FAS FLI1
15 muscle MP:0005369 10.08 CDK4 CDKN2A EPO ERBB2 FLI1 KIT
16 limbs/digits/tail MP:0005371 10 EPO ERBB2 FAS KIT KITLG RB1
17 normal MP:0002873 9.97 CDK4 EPO EPOR ERBB2 FAS KIT
18 no phenotypic analysis MP:0003012 9.88 CDKN2A CDKN2B EPOR KIT MTOR RB1
19 pigmentation MP:0001186 9.8 CDK4 CDKN2A FAS KIT KITLG RB1
20 renal/urinary system MP:0005367 9.8 CDK4 CDKN2B CSF3 FAS KIT MTOR
21 reproductive system MP:0005389 9.76 CDK4 CDKN2A CDKN2B ERBB2 FAS KIT
22 respiratory system MP:0005388 9.56 CDKN2A EPO EPOR ERBB2 FAS KIT
23 skeleton MP:0005390 9.23 CDKN2A EPO ERBB2 FAS KIT KITLG

Drugs & Therapeutics for Ewing's Family of Tumors

Drugs for Ewing's Family of Tumors (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 321)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4 329-65-7 838
2
Cortisone acetate Approved, Investigational Phase 4 1950-04-4, 50-04-4 5745
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
5
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
6
Darunavir Approved Phase 4 206361-99-1, 635728-49-3 213039
7
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
8
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
9 Dolutegravir Approved Phase 4 1051375-16-6 54726191
10
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
11
Cortisone Experimental Phase 4 53-06-5 222786
12
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
13 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1,Not Applicable
14 Hormones Phase 4,Phase 2,Phase 1
15 Hormone Antagonists Phase 4,Phase 2,Phase 1
16 glucocorticoids Phase 4,Phase 2,Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
18 Anti-HIV Agents Phase 4,Phase 2,Phase 1
19 Anti-Retroviral Agents Phase 4,Phase 2,Phase 1
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Antiviral Agents Phase 4,Phase 2,Phase 1,Early Phase 1
22 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Hydrocortisone 17-butyrate 21-propionate Phase 4,Not Applicable
24 Hydrocortisone-17-butyrate Phase 4
25 Cortisol succinate Phase 4,Not Applicable
26 Epinephryl borate Phase 4
27
protease inhibitors Phase 4,Phase 2
28 HIV Protease Inhibitors Phase 4,Phase 2
29 HIV Integrase Inhibitors Phase 4
30 Cytochrome P-450 CYP3A Inhibitors Phase 4
31 Integrase Inhibitors Phase 4
32 Cytochrome P-450 Enzyme Inhibitors Phase 4
33 Reverse Transcriptase Inhibitors Phase 4
34
Dactinomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 50-76-0 457193 2019
35
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
36
Etoposide Approved Phase 3,Phase 1,Phase 2,Not Applicable 33419-42-0 36462
37
Cobalt Approved, Experimental Phase 3,Phase 2 7440-48-4 104729
38
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
39
Ifosfamide Approved Phase 3,Phase 2,Phase 1,Not Applicable 3778-73-2 3690
40
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
41
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 57-22-7, 2068-78-2 5978
42
Melphalan Approved Phase 3,Phase 2,Phase 1,Not Applicable 148-82-3 4053 460612
43
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
44
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
45
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
46
Carboplatin Approved Phase 3,Phase 1,Phase 2,Not Applicable 41575-94-4 10339178 38904 498142
47
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
48
Rutin Approved, Experimental, Investigational Phase 3 153-18-4 5280805
49
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
50
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867

Interventional clinical trials:

(show top 50) (show all 303)
# Name Status NCT ID Phase Drugs
1 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
2 Dolutegravir and Darunavir Evaluation in Adults Failing Therapy Recruiting NCT03017872 Phase 4 NRTIs;Dolutegravir;Darunavir;Ritonavir
3 Body Composition Sub-study of the D2EFT Trial Not yet recruiting NCT03675815 Phase 4 Darunavir 800 MG Oral Tablet;Ritonavir 100 MG Oral Tablet;N(t)RTIs;Dolutegravir 50 MG Oral Tablet;TDF 300 MG Oral Tablet;3TC 300 MG Oral Tablet;FTC 200 MG Oral Cap
4 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
5 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
6 Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor Completed NCT00006734 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
7 Phlogenzym® in Patients With Acute Thrombophlebitis - Efficacy and Tolerance Completed NCT03470337 Phase 3 Phlogenzym
8 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
9 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
10 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
11 Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Recruiting NCT02063022 Phase 3 Standard treatment (as per protocol ISG SSG III);Intensified chemotherapy
12 Study in Localized and Disseminated Ewing Sarcoma Recruiting NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
13 Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma Recruiting NCT03495921 Phase 3 Irinotecan;Temozolomide
14 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Recruiting NCT02306161 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Vincristine Sulfate
15 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Topotecan Hydrochloride;Vincristine Sulfate
16 Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer Active, not recruiting NCT02856048 Phase 2, Phase 3 Triptorelin (GnRHa) + Chemotherapy
17 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
18 Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients Withdrawn NCT01734863 Phase 3
19 Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma Withdrawn NCT00334867 Phase 3 cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate
20 Hematopoietic Stem Cell Transplantation From Human Leukocyte Antigen (HLA) Compatible Donor in Ewing Sarcomas and Soft Tissues Sarcomas Unknown status NCT00998361 Phase 2
21 Pilot Study of Expanded , Activated Haploidentical Natural Killer Cell Infusions for Sarcomas Unknown status NCT02409576 Phase 1, Phase 2
22 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2 Vinorelbine, cyclofosfamide
23 Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors Unknown status NCT00179816 Phase 1, Phase 2 High-Dose Chemotherapy with Tandem PBSC Rescue.
24 Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases Unknown status NCT00084695 Phase 2 busulfan;cyclophosphamide;fludarabine phosphate;melphalan;methylprednisolone
25 Study of Zalypsis® (PM00104) in Patients With Unresectable Locally Advanced and/or Metastatic Ewing Family of Tumors (EFT) Progressing After at Least One Prior Line of Chemotherapy Completed NCT01222767 Phase 2 Zalypsis
26 Study of Intensive Chemotherapy, Surgery and Radiotherapy to Treat Ewing's Sarcoma in Children and Young Adults Completed NCT01696669 Phase 2 Chemotherapy
27 Imatinib Mesylate in Treating Patients With Recurrent Ewing's Family of Tumors or Desmoplastic Small Round-Cell Tumor Completed NCT00062205 Phase 2 imatinib mesylate
28 Olaparib in Adults With Recurrent/Metastatic Ewing's Sarcoma Completed NCT01583543 Phase 2 Olaparib
29 Eurosarc Trial of Linsitinib in Advanced Ewing Sarcoma Completed NCT02546544 Phase 2 Linsitinib
30 Study Of CP-751,871 In Patients With Ewing's Sarcoma Family Of Tumors Completed NCT00560235 Phase 1, Phase 2 CP-751,871
31 Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors Completed NCT00061893 Phase 2 celecoxib;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vinblastine sulfate;vincristine sulfate;MESNA;Filgrastim
32 Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors Completed NCT00070109 Phase 2 trabectedin
33 Aerosol L9-NC and Temozolomide in Ewing's Sarcoma Completed NCT00492141 Phase 1, Phase 2 Temozolomide;L9-NC
34 Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
35 Irinotecan in Treating Patients With Newly Diagnosed Ewing's Sarcoma Completed NCT00276692 Phase 2 irinotecan hydrochloride
36 Cytarabine in Treating Young Patients With Recurrent or Refractory Ewing's Sarcoma Completed NCT00470275 Phase 2 cytarabine
37 Busulfan, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk Ewing's Tumors Completed NCT00357396 Phase 2 busulfan;melphalan;thiotepa
38 New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma Completed NCT00001335 Phase 2 ADR-529;Topotecan;G-CSF
39 Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor Completed NCT00002643 Phase 2 amifostine trihydrate;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate
40 Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma Completed NCT00073983 Phase 2 docetaxel;gemcitabine hydrochloride
41 Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma Completed NCT00003667 Phase 2 cyclophosphamide;dexrazoxane hydrochloride;disaccharide tripeptide glycerol dipalmitoyl;doxorubicin hydrochloride;vincristine sulfate
42 Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in Patients With Relapsed/Refractory Ewing's Sarcoma and Neuroblastoma Completed NCT01492673 Phase 2 Cyclophosphamide, Topotecan, and Bevacizumab
43 Exatecan Mesylate in Treating Patients With Ewing's Sarcoma, Primitive Neuroectodermal Tumor, or Desmoplastic Small Round Cell Tumor Completed NCT00055952 Phase 2 exatecan mesylate
44 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
45 Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone Completed NCT00006234 Phase 1, Phase 2
46 Therapy to Treat Ewing's Sarcoma, Rhabdomyosarcoma or Neuroblastoma Completed NCT00923351 Phase 1, Phase 2 Tumor Purged/CD25 Depleted Lymphocytes;rhIL-7
47 A Five-Tier, Open-Label Study of IMC-A12 in Advanced Sarcoma Completed NCT00668148 Phase 2
48 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
49 QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors Completed NCT00563680 Phase 2 AMG 479
50 A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas Completed NCT00001566 Phase 2 indinavir sulfate

Search NIH Clinical Center for Ewing's Family of Tumors

Genetic Tests for Ewing's Family of Tumors

Anatomical Context for Ewing's Family of Tumors

MalaCards organs/tissues related to Ewing's Family of Tumors:

41
Brain, Kidney, Bone, Bone Marrow, Breast, Spinal Cord, Uterus

Publications for Ewing's Family of Tumors

Articles related to Ewing's Family of Tumors:

(show top 50) (show all 689)
# Title Authors Year
1
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor in the Adrenal Gland of a Child. ( 29891750 )
2018
2
Thyroid dysfunction in patients with childhood-onset medulloblastoma or primitive neuroectodermal tumor. ( 29969880 )
2018
3
Integrated bioinformatic analysis unveils significant genes and pathways in the pathogenesis of supratentorial primitive neuroectodermal tumor. ( 29670360 )
2018
4
Extraosseous Primary Intracranial Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor: Series of Seven Cases and Review of Literature. ( 29682023 )
2018
5
Renal Ewing sarcoma/primitive neuroectodermal tumor in a pregnant woman who underwent robot-assisted laparoscopic nephrectomy: a case report and literature review. ( 30349316 )
2018
6
A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing's family of tumors. ( 30093970 )
2018
7
Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival. ( 29992076 )
2018
8
Therapeutic approach in glioblastoma multiforme with primitive neuroectodermal tumor components: Case report and review of the literature. ( 29616127 )
2018
9
Is there an increased risk of spinal relapse in standard-risk medulloblastoma/primitive neuroectodermal tumor patients who receive only a reduced dose of craniospinal radiotherapy? ( 29868932 )
2018
10
Ewing-Like Sarcoma: A Case of a Primary Cutaneous Primitive Neuroectodermal Tumor With Atypical Immunohistochemistry and Lack of Fusion Oncogene Detection. ( 30067549 )
2018
11
Case report of an ewing's sarcoma/primitive neuroectodermal tumor of the kidney. ( 29946819 )
2018
12
A mesenteric primary peripheral Ewing's sarcoma/primitive neuroectodermal tumor with molecular cytogenetic analysis: Report of a rare case and review of literature. ( 29676369 )
2018
13
A rare case of Ewing's sarcoma/primitive neuroectodermal tumor metastasizing to left atrium through left inferior pulmonary vein. ( 29676474 )
2018
14
Atypical presentation of a germline APC mutation in a child with supratentorial primitive neuroectodermal tumor. ( 30511453 )
2018
15
Primitive neuroectodermal tumor transformation of testicular teratoma. ( 30386097 )
2018
16
Qualitative and quantitative CECT features for differentiating renal primitive neuroectodermal tumor from the renal cell carcinoma and its subtypes. ( 30362816 )
2018
17
Rare Ileal Ewing Sarcoma/Primitive Neuroectodermal Tumor on 18F-FDG PET/CT. ( 28806254 )
2017
18
Primary Ewing Sarcoma / Primitive Neuroectodermal Tumor of the Kidney: A Clinicopathologic Study of 23 Cases. ( 28429277 )
2017
19
Malignant glioma-primitive neuroectodermal tumor recurring as PNET-like only subdural collection: Case report. ( 29119041 )
2017
20
Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity. ( 28877739 )
2017
21
Outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS-PNET) - a retrospective analysis spanning 40 years of treatment. ( 28325133 )
2017
22
Primary Ewing's sarcoma/primitive neuroectodermal tumor of the ileum: case report of a 16-year-old Chinese female and literature review. ( 28472972 )
2017
23
Primary intracranial dural-based Ewing sarcoma/peripheral primitive neuroectodermal tumor mimicking a meningioma: A rare tumor with review of literature. ( 28761507 )
2017
24
A peripheral primitive neuroectodermal tumor in the larynx: A case report and literature review. ( 26893703 )
2016
25
Primary Ewing sarcoma/primitive neuroectodermal tumor in the adrenal gland. ( 27197626 )
2016
26
Management of Primitive Neuroectodermal Tumor of the Kidney with Inferior Vena Cava Thrombus. ( 26989372 )
2016
27
Cervicomedullary intramedullary peripheral primitive neuroectodermal tumor with intratumoral bleed: Report of one case and review of literature. ( 27217659 )
2016
28
Malignant glioma with primitive neuroectodermal tumor-like component (MG-PNET): novel microarray findings in a pediatric patient. ( 27781423 )
2016
29
Peripheral Primitive Neuroectodermal Tumor and Neurofibromatosis Type 1 in an Adolescent Male. ( 26828586 )
2016
30
Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: A Rare and Lethal Entity. ( 26927724 )
2016
31
Primary Ewing's Sarcoma/Primitive Neuroectodermal Tumor of Kidney with Caval Involvement in a Pregnant Woman. ( 27035149 )
2016
32
Cerebellopontine angle primitive neuroectodermal tumor mimicking trigeminal schwannoma. ( 26862446 )
2016
33
Development of CNS-type Primitive Neuroectodermal Tumor in Metastatic Testicular Mixed Germ Cell Tumor. ( 27169016 )
2016
34
Primitive Neuroectodermal Tumor of the Stomach: A Case Report. ( 27006299 )
2016
35
Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach. ( 27920700 )
2016
36
Primitive Neuroectodermal Tumor with Glioblastoma Multiforme Components in an Adult: A Collision Tumor. ( 26918224 )
2016
37
Primary Primitive Neuroectodermal Tumor Arising from an Ovarian Mature Cystic Teratoma in a 12-Year-Old Girl: A Case Report. ( 27919713 )
2016
38
Ewing sarcoma/primitive neuroectodermal tumor of the kidney: A report of three cases. ( 27776324 )
2016
39
Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant. ( 26773805 )
2016
40
Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide. ( 27324740 )
2016
41
Peripheral facial palsy, the only presentation of a primitive neuroectodermal tumor of the skull base. ( 26710328 )
2016
42
Treatment outcome and patterns of failure in patients of non-pineal supratentorial primitive neuroectodermal tumor: review of literature and clinical experience form a regional cancer center in north India. ( 25990846 )
2015
43
Endobronchial Primitive Neuroectodermal Tumor With Pneumothorax Ex Vacuo. ( 26434446 )
2015
44
Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature. ( 25780425 )
2015
45
Suprasellar Primitive Neuroectodermal Tumor in an Adult. ( 26517622 )
2015
46
Cyclin D1 is a useful marker for soft tissue Ewing's sarcoma/peripheral Primitive Neuroectodermal Tumor in children and adolescents: A comparative immunohistochemical study with rhabdomyosarcoma. ( 25765111 )
2015
47
Central-type primitive neuroectodermal tumor of the uterus: Case report of remission of stage IV disease using adjuvant cisplatin/etoposide/bevacizumab chemotherapy and review of the literature. ( 26793768 )
2015
48
Primary renal primitive neuroectodermal tumor: A rare presentation. ( 25766349 )
2015
49
Extraskeletal Ewing's sarcoma/primitive neuroectodermal tumor of the mediastinum: Significant response to chemoradiotherapy. ( 25621030 )
2015
50
Primitive neuroectodermal tumor/ewing sarcoma presenting with pulmonary nodular lesions. ( 25705534 )
2015

Variations for Ewing's Family of Tumors

Expression for Ewing's Family of Tumors

Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for Ewing's Family of Tumors

Pathways related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CDK4 CDKN2A CDKN2B EPOR ERBB2 KIT
2
Show member pathways
13.58 CSF3 EPO EPOR ERBB2 FAS KIT
3
Show member pathways
13.58 CDK4 CDKN2A CDKN2B CSF3 EPOR ERBB2
4
Show member pathways
13.29 CSF3 EPOR ERBB2 FAS KIT KITLG
5
Show member pathways
13.04 CDK4 CDKN2A CDKN2B EPO MTOR RB1
6
Show member pathways
12.97 CDK4 CDKN2A FAS MTOR RB1
7
Show member pathways
12.84 EPO EPOR FAS KIT KITLG
8
Show member pathways
12.73 CDK4 CDKN2A ERBB2 KIT MTOR RB1
9 12.67 ERBB2 FAS KIT KITLG
10
Show member pathways
12.64 ERBB2 KIT KITLG MTOR
11
Show member pathways
12.63 CDK4 CDKN2A CDKN2B ERBB2 MTOR RB1
12
Show member pathways
12.5 CDK4 CDKN2A CDKN2B RB1
13
Show member pathways
12.5 CDK4 CSF3 EPO EPOR ERBB2 FAS
14 12.49 FAS FLI1 KIT KITLG
15
Show member pathways
12.47 CDK4 CDKN2A CDKN2B ERBB2 KIT MTOR
16 12.36 CDK4 CDKN2A CDKN2B RB1
17
Show member pathways
12.33 CSF3 EPO EPOR MTOR
18
Show member pathways
12.31 EPOR ERBB2 KIT KITLG MTOR
19
Show member pathways
12.3 CDK4 CDKN2A FAS RB1
20
Show member pathways
12.27 CDK4 CDKN2A CDKN2B RB1
21 12.25 CDK4 CDKN2A CDKN2B KITLG RB1
22 12.21 CDK4 CDKN2A CDKN2B RB1
23
Show member pathways
12.21 CDK4 CDKN2A CDKN2B KIT KITLG RB1
24
Show member pathways
12.14 CDK4 ERBB2 MTOR RB1
25
Show member pathways
12.12 CDK4 CDKN2A CDKN2B RB1
26 12.08 CDK4 CDKN2A CDKN2B EPO EPOR ERBB2
27 12.07 CDK4 MTOR RB1
28
Show member pathways
12.07 EPO EPOR KIT KITLG
29 12.04 ERBB2 KIT KITLG
30 12.03 CDK4 CDKN2A CDKN2B MTOR RB1
31 11.9 CSF3 EPO KIT KITLG
32 11.88 CDKN2A MTOR RB1
33 11.87 CDK4 CDKN2A MTOR RB1
34 11.85 EPO ERBB2 MTOR
35 11.81 EPO EPOR MTOR
36 11.81 CDK4 CDKN2B RB1
37 11.69 CDKN2A ERBB2 FAS
38 11.65 CDK4 MTOR RB1
39 11.62 ERBB2 KIT MTOR
40 11.62 CDK4 CDKN2A ERBB2 RB1
41 11.54 CSF3 EPO EPOR KIT KITLG
42 11.48 CDKN2A FAS RB1
43 11.44 EPO KIT KITLG
44 11.41 CDK4 CDKN2B RB1
45 11.39 CSF3 EPO FLI1 KITLG
46 11.23 CDK4 CDKN2A CDKN2B
47 11.04 CDKN2A RB1
48 10.94 CSF3 EPOR ERBB2 KIT KITLG
49 10.89 KIT KITLG

GO Terms for Ewing's Family of Tumors

Biological processes related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 CDKN2A ERBB2 KIT MTOR
2 negative regulation of apoptotic process GO:0043066 9.88 EPO ERBB2 FAS KIT KITLG
3 positive regulation of cell proliferation GO:0008284 9.85 CDK4 CSF3 EPO KIT KITLG
4 phosphatidylinositol phosphorylation GO:0046854 9.74 ERBB2 KIT KITLG
5 G1/S transition of mitotic cell cycle GO:0000082 9.71 CDK4 CDKN2A RB1
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 CSF3 KITLG MTOR
7 positive regulation of translation GO:0045727 9.61 CDK4 ERBB2 MTOR
8 positive regulation of Ras protein signal transduction GO:0046579 9.6 EPO KITLG
9 negative regulation of phosphorylation GO:0042326 9.59 CDKN2A CDKN2B
10 embryonic hemopoiesis GO:0035162 9.58 KIT KITLG
11 megakaryocyte development GO:0035855 9.58 FLI1 KIT
12 response to hyperoxia GO:0055093 9.56 CDK4 EPO
13 cell cycle arrest GO:0007050 9.56 CDKN2A CDKN2B MTOR RB1
14 positive regulation of protein kinase B signaling GO:0051897 9.55 CSF3 ERBB2 KIT KITLG MTOR
15 positive regulation of MAP kinase activity GO:0043406 9.54 ERBB2 KIT KITLG
16 positive regulation of transcription by RNA polymerase III GO:0045945 9.52 ERBB2 MTOR
17 somatic stem cell division GO:0048103 9.49 CDKN2A KIT
18 ectopic germ cell programmed cell death GO:0035234 9.4 KIT KITLG
19 negative regulation of immature T cell proliferation in thymus GO:0033088 9.32 CDKN2A ERBB2
20 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.13 CDK4 CDKN2A CDKN2B
21 erythropoietin-mediated signaling pathway GO:0038162 8.8 EPO EPOR KIT
22 signal transduction GO:0007165 10.09 CDK4 EPO EPOR ERBB2 FAS KIT

Molecular functions related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.67 CDK4 ERBB2 KIT MTOR
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 ERBB2 KIT KITLG
3 identical protein binding GO:0042802 9.43 EPOR ERBB2 EWSR1 FAS MTOR RB1
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.16 CDKN2A CDKN2B
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 ERBB2 KIT KITLG
6 protein binding GO:0005515 10.07 CDK4 CDKN2A CDKN2B EPO EPOR ERBB2

Sources for Ewing's Family of Tumors

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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