Aliases & Classifications for Exanthema Subitum

Summaries for Exanthema Subitum

Disease Ontology : 12 A viral infectious disease that results in infection in infants and children, located in skin, has material basis in Human herpesvirus 6 or has material basis in Human herpesvirus 7 and has symptom sudden high fever, and has symptom red rash that occurs first on the trunk then spreading to legs and neck.

MalaCards based summary : Exanthema Subitum, also known as roseola infantum, is related to purpura and measles, and has symptoms including sudden high fever, red rash and exanthema. An important gene associated with Exanthema Subitum is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, skin and bone, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 76 Roseola is an infectious disease caused by certain types of virus. Most infections occur before the age... more...

Related Diseases for Exanthema Subitum

Diseases related to Exanthema Subitum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 purpura 30.4 IL6 ITGA2B THPO
2 measles 30.3 CD46 IL2 IL6
3 exanthem 30.3 IL2 IL6 TNFRSF1B
4 hemiplegia 10.4
5 febrile infection-related epilepsy syndrome 10.3 POLG SCN1A
6 light fixation seizure syndrome 10.2 CD40 CD40LG
7 acute cystitis 10.2
8 pyuria 10.2
9 rubella 10.2
10 immunodeficiency with hyper-igm, type 4 10.2 CD40 CD40LG
11 skin sarcoidosis 10.2 CD83 TNFRSF1B
12 histiocytoma 10.2
13 granulocytopenia 10.2
14 encephalopathy 10.2
15 generalized eruptive histiocytosis 10.2
16 primary thrombocytopenia 10.2 CD40LG ITGA2B THPO
17 megakaryocytic leukemia 10.1 ITGA2B KITLG THPO
18 cd40 ligand deficiency 10.1 CD40 CD40LG
19 agammaglobulinemia, x-linked 10.1 CD40 CD40LG IL2
20 streptococcal toxic-shock syndrome 10.1 IL2 IL6
21 hyperimmunoglobulin syndrome 10.1 CD40 CD40LG
22 immune deficiency disease 10.1 CD40 CD40LG IL2
23 necrotizing fasciitis 10.1 CD46 IL2 IL6
24 idiopathic neutropenia 10.1 CD40LG IL6 THPO
25 brucellosis 10.1 CD40LG IL2 IL6
26 autoimmune disease of musculoskeletal system 10.1 CD40LG IL2 IL6
27 common wart 10.1 CD40 CD80
28 paracoccidioidomycosis 10.1 CD86 IL2 IL6
29 uremic pruritus 10.0 IL2 IL6
30 toxoplasmosis 10.0 CD40 CD40LG IL6
31 primary bacterial infectious disease 10.0 IL2 IL6 TNFRSF1B
32 tetanus 10.0 CD40LG CD80 IL2
33 autoimmune disease of central nervous system 10.0 CD80 IL2 IL6
34 gingival overgrowth 10.0 FGF2 IL6 TIMP1
35 autoimmune disease of the nervous system 10.0 CD80 IL2 IL6
36 juvenile ankylosing spondylitis 9.9 CD80 IL6 TNFRSF1B
37 bone marrow cancer 9.9 FGF2 IL6 KITLG THPO
38 myocarditis 9.9 CD40 CD40LG CD86 IL6
39 bone inflammation disease 9.9 IL2 IL6 TIMP1 TNFRSF1B
40 aplastic anemia 9.9 IL2 IL6 ITGA2B KITLG THPO
41 myeloma, multiple 9.9 CD40 FGF2 IL2 IL6
42 viral infectious disease 9.9 CD40LG IL2 IL6
43 sezary's disease 9.9 CD7 IL2 TNFRSF1B
44 large intestine cancer 9.9 CD86 IL2 IL6 TIMP1
45 laryngitis 9.9 FGF2 IL6
46 common variable immunodeficiency 9.8 CD40 CD40LG CD86 IL2 IL6
47 sulfamethoxazole allergy 9.8 CD40 CD40LG CD80 CD83 CD86
48 mycosis fungoides 9.8 CD7 IL2 TNFRSF1B
49 leukemia, chronic lymphocytic 9.8 CD40 CD40LG CD80 IL2
50 hematologic cancer 9.8 CD7 IL2 KITLG THPO

Graphical network of the top 20 diseases related to Exanthema Subitum:



Diseases related to Exanthema Subitum

Symptoms & Phenotypes for Exanthema Subitum

Symptoms:

12
  • sudden high fever
  • red rash

UMLS symptoms related to Exanthema Subitum:


exanthema

MGI Mouse Phenotypes related to Exanthema Subitum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CD40 CD40LG CD7 CD80 CD83 CD86
2 cardiovascular system MP:0005385 10.26 CD40LG CD46 CD83 FGF2 IL2 IL6
3 endocrine/exocrine gland MP:0005379 10.21 CD40 CD40LG CD7 CD80 CD83 CD86
4 immune system MP:0005387 10.17 CD40 CD40LG CD7 CD80 CD83 CD86
5 cellular MP:0005384 10.16 CD40LG CD80 CD86 FGF2 IL2 IL6
6 homeostasis/metabolism MP:0005376 10.15 CD40 CD40LG CD86 FGF2 IL2 IL6
7 nervous system MP:0003631 9.9 CD40 CD40LG CD46 CD80 CD86 FGF2
8 neoplasm MP:0002006 9.8 FGF2 IL2 IL6 KITLG POLG TIMP1
9 reproductive system MP:0005389 9.7 CD40LG CD46 CD83 FGF2 IL2 IL6
10 skeleton MP:0005390 9.23 CD40 CD40LG FGF2 IL6 KITLG POLG

Drugs & Therapeutics for Exanthema Subitum

Search Clinical Trials , NIH Clinical Center for Exanthema Subitum

Cochrane evidence based reviews: exanthema subitum

Genetic Tests for Exanthema Subitum

Anatomical Context for Exanthema Subitum

The Foundational Model of Anatomy Ontology organs/tissues related to Exanthema Subitum:

19
Skin

MalaCards organs/tissues related to Exanthema Subitum:

41
Skin, Bone, Brain, T Cells, Myeloid, Bone Marrow, Small Intestine

Publications for Exanthema Subitum

Articles related to Exanthema Subitum:

(show top 50) (show all 55)
# Title Authors Year
1
Roseola Infantum (Exanthema Subitum, Sixth Disease) ( 28846307 )
2017
2
Roseola infantum and its causal human herpesviruses. ( 24673253 )
2014
3
Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum. ( 21655829 )
2011
4
Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum. ( 16628576 )
2006
5
Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum. ( 15807699 )
2005
6
Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum. ( 12615174 )
2003
7
Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum. ( 12374589 )
2002
8
The spectrum of human herpesvirus 6 infection: from roseola infantum to adult disease. ( 10774474 )
2000
9
Acute necrotising encephalopathy of childhood after exanthema subitum outside Japan or Taiwan. ( 10552022 )
1999
10
Neuroradiologic findings of brain lesions related to exanthema subitum. ( 9880137 )
1998
11
Primary human herpesvirus 7 infection and exanthema subitum. ( 8190552 )
1994
12
Roseola infantum and its correlation with HHV6. ( 8181511 )
1994
13
Exanthema subitum and human herpesvirus 6 infection: clinical observations in fifty-seven cases. ( 8383833 )
1993
14
Human herpesvirus-6 and roseola infantum. ( 8382727 )
1993
15
Serology versus clinical signs or symptoms and main laboratory findings in the diagnosis of exanthema subitum (roseola infantum). ( 1309393 )
1992
16
Liver dysfunction, anaemia, and granulocytopenia after exanthema subitum. ( 1359341 )
1992
17
Roseola infantum in pregnancy. A case report. ( 1460615 )
1992
18
Do second attacks of exanthema subitum result from human herpesvirus 6 reactivation or reinfection? ( 1649431 )
1991
19
Roseola infantum caused by human herpesvirus-6: report of 7 cases with emphasis on complications. ( 1681005 )
1991
20
Role of human herpesvirus 6 infection in infants with exanthema subitum. ( 2156215 )
1990
21
Seroreactivity to HHV-6 polypeptides in infants with exanthema subitum and their mothers. ( 2158895 )
1990
22
Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesviruses and HIV. ( 2155875 )
1990
23
Roseola infantum and human herpesvirus 6: old disease, new virus. Infectious Diseases and Immunization Committee, Canadian Paediatric Society. ( 2159836 )
1990
24
Roseola infantum and other syndromes associated with acute HHV6 infection. ( 2176778 )
1990
25
Immune response of patients with exanthema subitum to human herpesvirus type 6 (HHV-6) polypeptides. ( 2553827 )
1989
26
Thrombocytopenic purpura associated with exanthema subitum. ( 887348 )
1977
27
Exanthema subitum a review of 243 cases. ( 13958107 )
1963
28
Observation of nucleogeminy in urinary-sediment cells in the roseola-infantum syndrome. ( 14010320 )
1963
29
ROSEOLA INFANTUM. ( 14048883 )
1963
30
Roseola infantum. Description of atypical mononuclear cells as a characteristic feature of its blood picture. ( 13908628 )
1962
31
An exanthema subitum-like rash in patients with adenovirus infection. ( 14451249 )
1961
32
Roseola infantum. Another cause of bulging fontanel. ( 13731433 )
1961
33
A physical sign useful in diagnosis of roseola infantum before the rash. ( 13799552 )
1960
34
Residual encephalopathy following roseola infantum. ( 13669865 )
1959
35
Roseola infantum: a common cause of infantile convulsions. ( 13461064 )
1957
36
Isolation of adenovirus from an exanthematous infection resembling roseola infantum. ( 13474844 )
1957
37
Exanthema subitum and febrile convulsions. ( 13354383 )
1956
38
Roseola infantum; an isolated outbreak. ( 13320898 )
1956
39
Electron microscopic studies of the Roseola infantum (exanthem subitum) virus. ( 13281795 )
1955
40
An observation on the communicability of roseola infantum. ( 13234020 )
1955
41
Roseola infantum; a review of fifty cases. ( 13272349 )
1955
42
Roseola infantum; 13 cases seen in general practice. ( 14363773 )
1955
43
Roseola infantum. ( 13159496 )
1954
44
Isolation of a cytopathogenic agent from an infant with a disease in certain respects resembling roseola infantum. ( 13163404 )
1954
45
Experimental inoculation of roseola infantum. ( 14837736 )
1951
46
Infectious nature of exanthema subitum (roseola infantum). ( 14777168 )
1950
47
Studies on the etiology of exanthema subitum (roseola infantum). ( 14779257 )
1950
48
Roseola infantum. ( 14787616 )
1950
49
Roseola infantum. ( 14787617 )
1950
50
Hemiplegia associated with roseola infantum (exanthum subitum). ( 15439607 )
1950

Variations for Exanthema Subitum

Expression for Exanthema Subitum

Search GEO for disease gene expression data for Exanthema Subitum.

Pathways for Exanthema Subitum

Pathways related to Exanthema Subitum according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CD40 CD40LG CD46 CD80 CD86 FGF2
2
Show member pathways
13.82 CD40 CD40LG CD80 FGF2 IL2 IL6
3
Show member pathways
13.7 CD80 CD86 FGF2 IL2 IL6 ITGA2B
4
Show member pathways
13.63 CD40 CD40LG CD80 IL2 IL6 THPO
5
Show member pathways
13.51 CD80 FGF2 IL2 IL6 ITGA2B KITLG
6
Show member pathways
13.34 CD40 CD40LG CD80 FGF2 IL2 IL6
7
Show member pathways
13.27 CD40 CD40LG CD80 FGF2 IL2 IL6
8
Show member pathways
13.22 CD40 CD40LG CD80 CD86 FGF2 IL2
9
Show member pathways
13.04 FGF2 IL2 IL6 ITGA2B KITLG THPO
10
Show member pathways
13.02 FGF2 IL2 IL6 KITLG THPO TIMP1
11
Show member pathways
12.86 CD40 CD40LG CD80 CD86 IL2 IL6
12 12.8 FGF2 IL2 IL6 ITGA2B KITLG
13
Show member pathways
12.63 CD40 CD40LG CD80 CD86 IL2 TNFRSF1B
14 12.55 CD40LG CD46 CD83 IL2 KITLG TNFRSF1B
15
Show member pathways
12.53 FGF2 IL2 IL6 TIMP1
16
Show member pathways
12.43 CD40 CD40LG FGF2 IL2 IL6 KITLG
17
Show member pathways
12.39 CD40LG CD83 IL2 IL6
18
Show member pathways
12.38 CD40 CD40LG CD80 CD86 IL2
19
Show member pathways
12.38 FGF2 IL2 IL6 ITGA2B KITLG THPO
20
Show member pathways
12.25 FGF2 IL2 IL6 KITLG THPO TIMP1
21 12.1 CD40 CD40LG CD80 CD86
22 12.06 FGF2 IL6 KITLG THPO
23
Show member pathways
12.04 CD80 CD86 IL2 IL6
24 11.98 FGF2 IL6 TIMP1 TNFRSF1B
25
Show member pathways
11.94 CD80 FGF2 IL2 IL6 KITLG THPO
26 11.91 CD7 IL6 ITGA2B KITLG THPO
27 11.82 CD80 CD86 IL6
28 11.74 CD40 CD80 CD86 IL2 IL6
29 11.72 CD83 IL2 IL6
30
Show member pathways
11.72 CD40 CD40LG TNFRSF1B
31 11.71 FGF2 IL2 IL6 ITGA2B KITLG THPO
32 11.64 FGF2 IL6 TIMP1
33
Show member pathways
11.64 CD40LG IL2 IL6
34 11.61 CD40 CD40LG CD80 CD86
35 11.56 CD40 CD40LG CD80 CD83 CD86
36 11.52 CD40 CD40LG IL6
37 11.51 FGF2 IL6 KITLG
38 11.5 IL6 ITGA2B KITLG
39 11.49 CD80 CD86 IL6 TIMP1 TNFRSF1B
40 11.48 CD80 CD86 IL2
41 11.29 CD80 CD83 CD86 IL2 IL6 ITGA2B
42 11.19 CD40LG CD80 IL2 IL6
43 10.95 CD40 CD40LG CD80 CD86 IL2 TNFRSF1B
44 10.81 CD40LG CD80 FGF2 IL2 IL6 ITGA2B

GO Terms for Exanthema Subitum

Cellular components related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 CD40 CD40LG FGF2 IL2 IL6 KITLG
2 extracellular region GO:0005576 9.91 CD40 CD40LG FGF2 IL2 IL6 KITLG
3 cell surface GO:0009986 9.43 CD40 CD40LG CD46 CD80 CD86 ITGA2B
4 varicosity GO:0043196 9.16 CD40 TNFRSF1B
5 external side of plasma membrane GO:0009897 9.1 CD40 CD40LG CD80 CD83 CD86 ITGA2B
6 plasma membrane GO:0005886 10.15 CD40 CD40LG CD46 CD7 CD80 CD83

Biological processes related to Exanthema Subitum according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 CD40 CD46 CD7 CD86 IL2 TARM1
2 adaptive immune response GO:0002250 9.88 CD46 CD7 CD86 IL2 TARM1
3 positive regulation of cell proliferation GO:0008284 9.87 CD86 FGF2 IL2 IL6 KITLG THPO
4 positive regulation of protein phosphorylation GO:0001934 9.85 CD40 IL2 THPO WDFY2
5 platelet activation GO:0030168 9.81 CD40 CD40LG IL6
6 positive regulation of protein kinase B signaling GO:0051897 9.8 CD80 CD86 FGF2 KITLG THPO
7 immune response GO:0006955 9.8 CD40LG CD7 CD80 CD86 IL2 IL6
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.79 CD80 IL6 KITLG
9 viral entry into host cell GO:0046718 9.78 CD46 CD80 CD86
10 cellular response to lipopolysaccharide GO:0071222 9.77 CD40 CD80 CD86 IL6 TNFRSF1B
11 phosphatidylinositol phosphorylation GO:0046854 9.76 CD80 CD86 FGF2 KITLG
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 CD40 IL2 IL6
13 tumor necrosis factor-mediated signaling pathway GO:0033209 9.74 CD40 CD40LG TNFRSF1B
14 positive regulation of MAP kinase activity GO:0043406 9.73 CD40 FGF2 KITLG
15 T cell costimulation GO:0031295 9.71 CD40LG CD80 CD86
16 regulation of signaling receptor activity GO:0010469 9.7 CD40LG FGF2 IL2 IL6 KITLG THPO
17 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.62 CD80 CD86
18 positive regulation of leukocyte migration GO:0002687 9.62 ITGA2B KITLG
19 positive regulation of interleukin-10 production GO:0032733 9.61 CD40LG CD46 CD83
20 positive regulation of immunoglobulin secretion GO:0051024 9.6 IL2 IL6
21 positive regulation of regulatory T cell differentiation GO:0045591 9.59 CD46 IL2
22 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 CD40 IL2
23 positive regulation of hematopoietic stem cell proliferation GO:1902035 9.52 KITLG THPO
24 regulation of immunoglobulin secretion GO:0051023 9.51 CD40 CD40LG
25 cytokine-mediated signaling pathway GO:0019221 9.5 CD80 CD86 FGF2 IL2 IL6 TIMP1
26 positive regulation of T cell proliferation GO:0042102 9.1 CD40LG CD46 CD80 CD86 IL2 IL6
27 negative regulation of apoptotic process GO:0043066 10.03 CD40LG IL2 IL6 KITLG TIMP1

Molecular functions related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.62 CD40 CD46 CD7 CD86
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGF2 IL2 KITLG
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.46 CD80 CD86 FGF2 KITLG
4 virus receptor activity GO:0001618 9.43 CD46 CD80 CD86
5 growth factor activity GO:0008083 9.43 FGF2 IL2 IL6 KITLG THPO TIMP1
6 cytokine activity GO:0005125 9.17 CD40LG FGF2 IL2 IL6 KITLG THPO

Sources for Exanthema Subitum

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19 FMA
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