Aliases & Classifications for Exanthema Subitum

Summaries for Exanthema Subitum

Disease Ontology : 12 A viral infectious disease that results in infection in infants and children, located in skin, has material basis in Human herpesvirus 6 or has material basis in Human herpesvirus 7 and has symptom sudden high fever, and has symptom red rash that occurs first on the trunk then spreading to legs and neck.

MalaCards based summary : Exanthema Subitum, also known as roseola infantum, is related to purpura and measles, and has symptoms including sudden high fever, red rash and exanthema. An important gene associated with Exanthema Subitum is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include skin, skin and liver, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 76 Roseola is an infectious disease caused by certain types of virus. Most infections occur before the age... more...

Related Diseases for Exanthema Subitum

Diseases related to Exanthema Subitum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 purpura 30.8 CD40LG ITGA2B THPO
2 measles 30.7 CD40LG CD46 IL2
3 febrile infection-related epilepsy syndrome 10.9 POLG SCN1A
4 exanthem 10.7
5 light fixation seizure syndrome 10.7 CD40 CD40LG
6 transient neonatal neutropenia 10.6 FCGR3A FCGR3B
7 rift valley fever 10.6 CD40LG CD83
8 immunodeficiency with hyper-igm, type 4 10.6 CD40 CD40LG
9 thrombocytopenia due to platelet alloimmunization 10.5 CD40LG ITGA2B THPO
10 primary thrombocytopenia 10.5 CD40LG ITGA2B THPO
11 autoimmune disease of blood 10.5 CD40LG ITGA2B THPO
12 murray valley encephalitis 10.5 CD40LG IL2
13 blood coagulation disease 10.5 CD40LG ITGA2B THPO
14 mumps 10.5 CD40LG CD46 IL2
15 hyperimmunoglobulin syndrome 10.5 CD40 CD40LG
16 spastic paraplegia 32, autosomal recessive 10.5 FCGR3A FCGR3B
17 hemorrhagic disease 10.5 CD40LG ITGA2B THPO
18 blood platelet disease 10.5 CD40LG ITGA2B THPO
19 cd40 ligand deficiency 10.5 CD40 CD40LG
20 pulmonary embolism and infarction 10.4 CD40LG WDFY2
21 immunodeficiency with hyper-igm, type 3 10.4 CD40 CD40LG
22 leukocyte disease 10.4 CD40LG IL2 KITLG
23 pleuropneumonia 10.4 CD40LG FCGR3A FCGR3B
24 megakaryocytic leukemia 10.4 ITGA2B KITLG THPO
25 ophthalmia neonatorum 10.3 CD40LG WDFY2
26 immune defect due to absence of thymus 10.3 CD40LG IL2
27 rheumatic myocarditis 10.3 FCGR3A FCGR3B
28 acquired immunodeficiency syndrome 10.3 CD40LG FCGR3A IL2
29 splenic disease 10.2 CD40LG THPO
30 combined immunodeficiency, x-linked 10.2 CD40 CD40LG IL2
31 common wart 10.1 CD40 CD80
32 hemiplegia 10.1
33 pyuria 10.1
34 rubella 10.1
35 immune deficiency disease 10.1 CD40 CD40LG IL2
36 myocarditis 10.1 CD40 CD40LG CD86
37 immune system disease 10.1 CD40LG IL2 ITGA2B THPO
38 aging 10.1
39 histiocytoma 10.1
40 granulocytopenia 10.1
41 encephalopathy 10.1
42 generalized eruptive histiocytosis 10.1
43 tetanus 10.0 CD40LG CD80 IL2
44 type 1 diabetes mellitus 13 10.0 CD80 CD86
45 neutropenia 10.0 FCGR3A FCGR3B KITLG THPO
46 aplastic anemia 9.9 IL2 ITGA2B KITLG THPO
47 type 1 diabetes mellitus 6 9.8 CD80 CD86
48 orbital plasma cell granuloma 9.8 FCGR3A FCGR3B
49 lymphoma, non-hodgkin, familial 9.8 CD40 CD40LG FCGR3A IL2
50 common variable immunodeficiency 9.7 CD40 CD40LG CD86 IL2

Graphical network of the top 20 diseases related to Exanthema Subitum:



Diseases related to Exanthema Subitum

Symptoms & Phenotypes for Exanthema Subitum

Symptoms:

12
  • sudden high fever
  • red rash

UMLS symptoms related to Exanthema Subitum:


exanthema

MGI Mouse Phenotypes related to Exanthema Subitum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 APEX1 CD40LG CD46 CD83 IL2 ITGA2B
2 endocrine/exocrine gland MP:0005379 9.96 APEX1 CD40 CD40LG CD7 CD80 CD83
3 hematopoietic system MP:0005397 9.93 CD40 CD40LG CD7 CD80 CD83 CD86
4 immune system MP:0005387 9.77 IL2 ITGA2B KITLG POLG THPO APEX1
5 reproductive system MP:0005389 9.28 CD46 CD83 IL2 ITGA2B KITLG POLG

Drugs & Therapeutics for Exanthema Subitum

Search Clinical Trials , NIH Clinical Center for Exanthema Subitum

Cochrane evidence based reviews: exanthema subitum

Genetic Tests for Exanthema Subitum

Anatomical Context for Exanthema Subitum

The Foundational Model of Anatomy Ontology organs/tissues related to Exanthema Subitum:

19
Skin

MalaCards organs/tissues related to Exanthema Subitum:

41
Skin, Liver, Brain

Publications for Exanthema Subitum

Articles related to Exanthema Subitum:

(show all 23)
# Title Authors Year
1
Roseola Infantum (Exanthema Subitum, Sixth Disease) ( 28846307 )
2017
2
Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum. ( 21655829 )
2011
3
Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum. ( 16628576 )
2006
4
Generalized eruptive histiocytoma with rapid progression and resolution following exanthema subitum. ( 15807699 )
2005
5
Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum. ( 12615174 )
2003
6
Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum. ( 12374589 )
2002
7
Acute necrotising encephalopathy of childhood after exanthema subitum outside Japan or Taiwan. ( 10552022 )
1999
8
Neuroradiologic findings of brain lesions related to exanthema subitum. ( 9880137 )
1998
9
Primary human herpesvirus 7 infection and exanthema subitum. ( 8190552 )
1994
10
Exanthema subitum and human herpesvirus 6 infection: clinical observations in fifty-seven cases. ( 8383833 )
1993
11
Serology versus clinical signs or symptoms and main laboratory findings in the diagnosis of exanthema subitum (roseola infantum). ( 1309393 )
1992
12
Liver dysfunction, anaemia, and granulocytopenia after exanthema subitum. ( 1359341 )
1992
13
Do second attacks of exanthema subitum result from human herpesvirus 6 reactivation or reinfection? ( 1649431 )
1991
14
Role of human herpesvirus 6 infection in infants with exanthema subitum. ( 2156215 )
1990
15
Seroreactivity to HHV-6 polypeptides in infants with exanthema subitum and their mothers. ( 2158895 )
1990
16
Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesviruses and HIV. ( 2155875 )
1990
17
Immune response of patients with exanthema subitum to human herpesvirus type 6 (HHV-6) polypeptides. ( 2553827 )
1989
18
Thrombocytopenic purpura associated with exanthema subitum. ( 887348 )
1977
19
Exanthema subitum a review of 243 cases. ( 13958107 )
1963
20
An exanthema subitum-like rash in patients with adenovirus infection. ( 14451249 )
1961
21
Exanthema subitum and febrile convulsions. ( 13354383 )
1956
22
Infectious nature of exanthema subitum (roseola infantum). ( 14777168 )
1950
23
Roseola infantum (exanthema subitum). ( 18135038 )
1949

Variations for Exanthema Subitum

Expression for Exanthema Subitum

Search GEO for disease gene expression data for Exanthema Subitum.

Pathways for Exanthema Subitum

Pathways related to Exanthema Subitum according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CD40 CD40LG CD46 CD80 CD86 FCGR3A
2
Show member pathways
13.23 CD40 CD40LG CD80 IL2 ITGA2B KITLG
3
Show member pathways
13.18 CD40 CD40LG CD80 CD86 IL2 ITGA2B
4
Show member pathways
13.1 CD40 CD40LG CD80 IL2 KITLG THPO
5
Show member pathways
12.69 CD40 CD40LG CD80 CD86 IL2
6
Show member pathways
12.51 CD40 CD40LG IL2 KITLG THPO
7 12.25 APEX1 CD40LG CD46 CD83 IL2 KITLG
8
Show member pathways
12.15 CD40 CD40LG CD80 CD86 IL2
9
Show member pathways
12.05 CD40 CD40LG FCGR3A FCGR3B
10 11.89 CD40 CD40LG CD80 CD86
11 11.87 CD40 CD40LG FCGR3A
12 11.69 CD7 ITGA2B KITLG THPO
13 11.39 CD40 CD40LG CD80 CD86
14 11.3 CD80 CD86 IL2
15 11.28 CD40 CD40LG CD80 CD83 CD86
16 11.23 CD80 CD83 CD86 IL2 ITGA2B KITLG
17 10.87 CD40 CD40LG CD80 CD86 IL2

GO Terms for Exanthema Subitum

Cellular components related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 CD40 CD40LG CD46 CD7 CD80 CD83
2 cell surface GO:0009986 9.63 CD40 CD40LG CD46 CD80 CD86 ITGA2B
3 external side of plasma membrane GO:0009897 9.17 CD40 CD40LG CD80 CD83 CD86 FCGR3A
4 integral component of membrane GO:0016021 10.07 CD40 CD40LG CD46 CD7 CD80 CD83

Biological processes related to Exanthema Subitum according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 CD40 CD46 CD7 CD86 IL2 TARM1
2 cellular response to lipopolysaccharide GO:0071222 9.75 CD40 CD80 CD86
3 phosphatidylinositol phosphorylation GO:0046854 9.73 CD80 CD86 KITLG
4 positive regulation of protein phosphorylation GO:0001934 9.71 CD40 IL2 THPO WDFY2
5 viral entry into host cell GO:0046718 9.7 CD46 CD80 CD86
6 T cell costimulation GO:0031295 9.67 CD40LG CD80 CD86
7 positive regulation of protein kinase B signaling GO:0051897 9.67 CD80 CD86 KITLG THPO
8 adaptive immune response GO:0002250 9.65 CD46 CD7 CD86 IL2 TARM1
9 positive regulation of endothelial cell apoptotic process GO:2000353 9.57 CD40 CD40LG
10 immune response GO:0006955 9.56 CD40 CD40LG CD7 CD80 CD86 FCGR3A
11 positive regulation of leukocyte migration GO:0002687 9.55 ITGA2B KITLG
12 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.54 CD80 CD86
13 positive regulation of regulatory T cell differentiation GO:0045591 9.51 CD46 IL2
14 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 CD40 IL2
15 positive regulation of hematopoietic stem cell proliferation GO:1902035 9.46 KITLG THPO
16 regulation of immunoglobulin secretion GO:0051023 9.43 CD40 CD40LG
17 positive regulation of interleukin-10 production GO:0032733 9.33 CD40LG CD46 CD83
18 positive regulation of T cell proliferation GO:0042102 9.02 CD40LG CD46 CD80 CD86 IL2

Molecular functions related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.43 CD46 CD80 CD86
2 3-5 exonuclease activity GO:0008408 9.37 APEX1 POLG
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 CD80 CD86 KITLG
4 IgG binding GO:0019864 9.32 FCGR3A FCGR3B
5 cytokine activity GO:0005125 9.26 CD40LG IL2 KITLG THPO
6 signaling receptor activity GO:0038023 8.92 CD40 CD46 CD7 CD86

Sources for Exanthema Subitum

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74 UMLS via Orphanet
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