MCID: EXN001
MIFTS: 32

Exanthema Subitum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Exanthema Subitum

MalaCards integrated aliases for Exanthema Subitum:

Name: Exanthema Subitum 12 43 15 17 71
Roseola Infantum 12 74
Sixth Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050495
ICD9CM 34 058.1 058.10
MeSH 43 D005077
SNOMED-CT 67 54385001
ICD10 32 B08.2 B08.20
UMLS 71 C0015231

Summaries for Exanthema Subitum

Disease Ontology : 12 A viral infectious disease that results in infection in infants and children, located in skin, has material basis in Human herpesvirus 6 or has material basis in Human herpesvirus 7 and has symptom sudden high fever, and has symptom red rash that occurs first on the trunk then spreading to legs and neck.

MalaCards based summary : Exanthema Subitum, also known as roseola infantum, is related to iridocyclitis and drug allergy, and has symptoms including sudden high fever, red rash and exanthema. An important gene associated with Exanthema Subitum is SNORD94 (Small Nucleolar RNA, C/D Box 94). Affiliated tissues include skin, brain and bone.

Wikipedia : 74 Roseola is an infectious disease caused by certain types of virus. Most infections occur before the age... more...

Related Diseases for Exanthema Subitum

Diseases related to Exanthema Subitum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 30.1 CD40LG CD4
2 drug allergy 30.0 CD40LG CD4
3 exanthem 10.7
4 febrile seizures 10.6
5 rubella 10.5
6 measles 10.4
7 encephalitis 10.4
8 granulocytopenia 10.4
9 encephalopathy 10.4
10 hemiplegia 10.4
11 visual epilepsy 10.3
12 seizure disorder 10.3
13 aseptic meningitis 10.2
14 neutropenia 10.2
15 acute cystitis 10.2
16 pyuria 10.2
17 otitis media 10.2
18 hydrops, lactic acidosis, and sideroblastic anemia 10.2
19 penicillin allergy 10.2
20 mumps 10.2
21 dengue disease 10.2
22 thrombocytopenia 10.2
23 gastroenteritis 10.2
24 purpura 10.2
25 histiocytoma 10.2
26 brain edema 10.2
27 carotid artery occlusion 10.2
28 chickenpox 10.2
29 cytomegalovirus infection 10.2
30 generalized eruptive histiocytosis 10.2
31 riedel's fibrosing thyroiditis 9.9 CD40LG CD4
32 cork-handlers' disease 9.9 CD40LG CD4
33 syphilitic meningitis 9.9 CD40LG CD4
34 early yaws 9.9 CD40LG CD4
35 latent syphilis 9.9 CD40LG CD4
36 gastroduodenitis 9.9 CD40LG CD4
37 duodenitis 9.9 CD40LG CD4
38 primary syphilis 9.9 CD40LG CD4
39 asymptomatic neurosyphilis 9.9 CD40LG CD4
40 tertiary neurosyphilis 9.9 CD40LG CD4
41 transient arthritis 9.9 CD40LG CD4
42 norwegian scabies 9.9 CD40LG CD4
43 neuroretinitis 9.9 CD40LG CD4
44 meningovascular neurosyphilis 9.9 CD40LG CD4
45 optic papillitis 9.9 CD40LG CD4
46 viral exanthem 9.9 CD40LG CD4
47 tertiary syphilis 9.9 CD40LG CD4
48 acute retinal necrosis syndrome 9.9 CD40LG CD4
49 granulomatous hepatitis 9.9 CD40LG CD4
50 cerebral lymphoma 9.9 CD40LG CD4

Graphical network of the top 20 diseases related to Exanthema Subitum:



Diseases related to Exanthema Subitum

Symptoms & Phenotypes for Exanthema Subitum

Symptoms:

12
  • sudden high fever
  • red rash

UMLS symptoms related to Exanthema Subitum:


exanthema

Drugs & Therapeutics for Exanthema Subitum

Search Clinical Trials , NIH Clinical Center for Exanthema Subitum

Cochrane evidence based reviews: exanthema subitum

Genetic Tests for Exanthema Subitum

Anatomical Context for Exanthema Subitum

The Foundational Model of Anatomy Ontology organs/tissues related to Exanthema Subitum:

19
Skin

MalaCards organs/tissues related to Exanthema Subitum:

40
Skin, Brain, Bone, Liver, Bone Marrow, Heart, Testes

Publications for Exanthema Subitum

Articles related to Exanthema Subitum:

(show top 50) (show all 281)
# Title Authors PMID Year
1
Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A. 61
31972018 2020
2
HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells. 61
31521763 2019
3
Clinical Characteristics of Primary HHV-6B Infection in Children Visiting the Emergency Room. 61
31261358 2019
4
HHV-6 Infection in an Immunocompetent Patient with Multi-organ Failure. 61
31646134 2019
5
Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress. 61
30427305 2019
6
Entry of betaherpesviruses. 61
31439151 2019
7
An evaluation of HHV-6 as an etiologic agent in Hodgkin lymphoma and brain cancer using IARC criteria for oncogenicity. 61
31709003 2019
8
Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case-control study in a referral hospital in Zambia. 61
30011348 2018
9
Chromosomally integrated human herpesvirus 6 in the Japanese population. 61
29905966 2018
10
Oral propranolol for infantile hemangiomas beyond the proliferative phase. 61
30051930 2018
11
[Encephalopathy due to human herpesvirus 6 infection as exanthema subitum complication]. 61
29557623 2018
12
Unique cell tropism of HHV-6B in an infantile autopsy case of primary HHV-6B encephalitis. 61
29582466 2018
13
The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola. 61
29489601 2018
14
Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab. 61
29785130 2018
15
Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis. 61
28342868 2017
16
Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult. 61
28545483 2017
17
Update on infections with human herpesviruses 6A, 6B, and 7. 61
27773488 2017
18
[Serological and molecular methods in diagnostics of primary acute hepatitis caused with human herpesvirus type 6 - a case report]. 61
30351623 2017
19
Human Herpesviruses 6A, 6B, and 7. 61
27337451 2016
20
Focal Coxsackie virus B5 encephalitis with synchronous seizure cluster and eruption: Infantile case. 61
26711006 2016
21
Predicting the characteristics of the aetiological agent for Kawasaki disease from other paediatric infectious diseases in Japan. 61
26201398 2016
22
Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia. 61
27980872 2016
23
Human herpesvirus-6 infection-associated acute encephalopathy without skin rash. 61
25582898 2015
24
Laboratory and clinical aspects of human herpesvirus 6 infections. 61
25762531 2015
25
Clinical impact of primary infection with roseoloviruses. 61
25462439 2014
26
Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures. 61
25156011 2014
27
Detection of human herpesvirus 6 in cerebrospinal fluid of children with possible encephalitis. 61
25485059 2014
28
Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders. 61
25160553 2014
29
Roseola infantum and its causal human herpesviruses. 61
24673253 2014
30
Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion. 61
25705358 2014
31
Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection. 61
24380721 2014
32
[Case classification in measles surveillance system under the Two-level Logistic Model]. 61
24685039 2014
33
Mapping the telomere integrated genome of human herpesvirus 6A and 6B. 61
23648233 2013
34
The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection. 61
23769070 2013
35
Differentiating roseola infantum with pyuria from urinary tract infection. 61
23190314 2013
36
Animal models for human herpesvirus 6 infection. 61
23847599 2013
37
Human herpes virus type 6 can cause skin lesions at the BCG inoculation site similar to Kawasaki Disease. 61
23138414 2012
38
Catastrophic Kawasaki disease unresponsive to IVIG in a 3-month-old infant: a diagnostic and therapeutic challenge. 61
22929725 2012
39
Mutations of the SCN1A gene in acute encephalopathy. 61
22309220 2012
40
Age-specific sex-related differences in infections: a statistical analysis of national surveillance data in Japan. 61
22848753 2012
41
An epidemiological study of children with status epilepticus in Okayama, Japan: incidence, etiologies, and outcomes. 61
21741214 2011
42
Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. 61
21571030 2011
43
Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum. 61
21655829 2011
44
[Exanthema subitum - 3 day fever - HHV 6 infection - roseola infantum - 6th disease]. 61
21744571 2011
45
Improvement of intractable childhood epilepsy following acute viral infection. 61
20144516 2011
46
[HHV-6 infection and its clinical significance]. 61
21805894 2011
47
[Human herpesvirus-6 and human herpesvirus-7 (HHV-6, HHV-7)]. 61
21488335 2010
48
Impact of human herpes virus 6 in liver transplantation. 61
21161019 2010
49
Human herpesvirus 6B induces phenotypic maturation without IL-10 and IL-12p70 production in dendritic cells. 61
20500695 2010
50
Human herpesvirus-6 in patients with Crohn's disease. 61
20477816 2010

Variations for Exanthema Subitum

Expression for Exanthema Subitum

Search GEO for disease gene expression data for Exanthema Subitum.

Pathways for Exanthema Subitum

GO Terms for Exanthema Subitum

Biological processes related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-10 production GO:0032733 8.96 CD46 CD40LG
2 positive regulation of T cell proliferation GO:0042102 8.8 CD46 CD40LG CD4

Sources for Exanthema Subitum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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