MCID: EXN001
MIFTS: 42

Exanthema Subitum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Exanthema Subitum

MalaCards integrated aliases for Exanthema Subitum:

Name: Exanthema Subitum 12 44 15 17 72
Roseola Infantum 12 75
Sixth Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050495
ICD9CM 35 058.1 058.10
MeSH 44 D005077
SNOMED-CT 68 54385001
ICD10 33 B08.2 B08.20
UMLS 72 C0015231

Summaries for Exanthema Subitum

Disease Ontology : 12 A viral infectious disease that results in infection in infants and children, located in skin, has material basis in Human herpesvirus 6 or has material basis in Human herpesvirus 7 and has symptom sudden high fever, and has symptom red rash that occurs first on the trunk then spreading to legs and neck.

MalaCards based summary : Exanthema Subitum, also known as roseola infantum, is related to exanthem and febrile infection-related epilepsy syndrome, and has symptoms including sudden high fever, red rash and exanthema. An important gene associated with Exanthema Subitum is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. Affiliated tissues include skin, liver and brain, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 75 Roseola is an infectious disease caused by certain types of virus. Most infections occur before the age... more...

Related Diseases for Exanthema Subitum

Diseases related to Exanthema Subitum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 exanthem 10.7
2 febrile infection-related epilepsy syndrome 10.6 SCN1A POLG
3 febrile seizures 10.6
4 rubella 10.5
5 light fixation seizure syndrome 10.5 CD40LG CD40
6 measles 10.4
7 encephalitis 10.4
8 granulocytopenia 10.4
9 encephalopathy 10.4
10 immunodeficiency with hyper-igm, type 4 10.4 CD40LG CD40
11 transient neonatal neutropenia 10.4 FCGR3B FCGR3A
12 hemiplegia 10.4
13 cd40 ligand deficiency 10.3 CD40LG CD40
14 visual epilepsy 10.3
15 seizure disorder 10.3
16 immunodeficiency with hyper-igm, type 3 10.3 CD40LG CD40
17 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.3 IL2 CD40LG CD4
18 aseptic meningitis 10.2
19 neutropenia 10.2
20 acute cystitis 10.2
21 pyuria 10.2
22 megakaryocytic leukemia 10.2 THPO KITLG ITGA2B
23 otitis media 10.2
24 hydrops, lactic acidosis, and sideroblastic anemia 10.2
25 drug allergy 10.2
26 penicillin allergy 10.2
27 mumps 10.2
28 dengue disease 10.2
29 thrombocytopenia 10.2
30 gastroenteritis 10.2
31 purpura 10.2
32 histiocytoma 10.2
33 brain edema 10.2
34 carotid artery occlusion 10.2
35 chickenpox 10.2
36 iridocyclitis 10.2
37 anterior uveitis 10.2
38 cytomegalovirus infection 10.2
39 generalized eruptive histiocytosis 10.2
40 viral infectious disease 10.2 IL2 CD40LG CD4
41 immune deficiency disease 10.1 IL2 CD40LG CD40
42 common wart 10.1 CD80 CD40
43 primary thrombocytopenia 10.0 THPO ITGA2B FCGR3A CD40LG
44 tetanus 10.0 IL2 CD80 CD40LG
45 myocarditis 9.9 CD86 CD40LG CD40
46 type 1 diabetes mellitus 13 9.9 CD86 CD80
47 immunodeficiency with hyper-igm, type 1 9.8 CD40LG CD40
48 type 1 diabetes mellitus 6 9.8 CD86 CD80
49 aplastic anemia 9.8 THPO KITLG ITGA2B IL2
50 myositis fibrosa 9.8 CD86 CD80

Graphical network of the top 20 diseases related to Exanthema Subitum:



Diseases related to Exanthema Subitum

Symptoms & Phenotypes for Exanthema Subitum

Symptoms:

12
  • sudden high fever
  • red rash

UMLS symptoms related to Exanthema Subitum:


exanthema

MGI Mouse Phenotypes related to Exanthema Subitum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CD4 CD40 CD40LG CD7 CD80 CD83
2 endocrine/exocrine gland MP:0005379 10.06 APEX1 CD4 CD40 CD40LG CD7 CD80
3 cardiovascular system MP:0005385 10.02 APEX1 CD40LG CD46 CD83 IL2 ITGA2B
4 homeostasis/metabolism MP:0005376 9.9 APEX1 CD4 CD40 CD40LG CD86 FCGR3B
5 immune system MP:0005387 9.8 APEX1 CD4 CD40 CD40LG CD7 CD80
6 reproductive system MP:0005389 9.28 APEX1 CD40LG CD46 CD83 IL2 ITGA2B

Drugs & Therapeutics for Exanthema Subitum

Search Clinical Trials , NIH Clinical Center for Exanthema Subitum

Cochrane evidence based reviews: exanthema subitum

Genetic Tests for Exanthema Subitum

Anatomical Context for Exanthema Subitum

MalaCards organs/tissues related to Exanthema Subitum:

41
Skin, Liver, Brain, Bone, Bone Marrow, Heart, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Exanthema Subitum:

19
Skin

Publications for Exanthema Subitum

Articles related to Exanthema Subitum:

(show top 50) (show all 277)
# Title Authors PMID Year
1
Erratum. 38
31284733 2019
2
Clinical Characteristics of Primary HHV-6B Infection in Children Visiting the Emergency Room. 38
31261358 2019
3
Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress. 38
30427305 2019
4
Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case-control study in a referral hospital in Zambia. 38
30011348 2018
5
Chromosomally integrated human herpesvirus 6 in the Japanese population. 38
29905966 2018
6
Oral propranolol for infantile hemangiomas beyond the proliferative phase. 38
30051930 2018
7
[Encephalopathy due to human herpesvirus 6 infection as exanthema subitum complication]. 38
29557623 2018
8
Unique cell tropism of HHV-6B in an infantile autopsy case of primary HHV-6B encephalitis. 38
29582466 2018
9
The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola. 38
29489601 2018
10
Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab. 38
29785130 2018
11
Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis. 38
28342868 2017
12
Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult. 38
28545483 2017
13
Update on infections with human herpesviruses 6A, 6B, and 7. 38
27773488 2017
14
[Serological and molecular methods in diagnostics of primary acute hepatitis caused with human herpesvirus type 6 - a case report]. 38
30351623 2017
15
Human Herpesviruses 6A, 6B, and 7. 38
27337451 2016
16
Focal Coxsackie virus B5 encephalitis with synchronous seizure cluster and eruption: Infantile case. 38
26711006 2016
17
Predicting the characteristics of the aetiological agent for Kawasaki disease from other paediatric infectious diseases in Japan. 38
26201398 2016
18
Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia. 38
27980872 2016
19
Human herpesvirus-6 infection-associated acute encephalopathy without skin rash. 38
25582898 2015
20
Laboratory and clinical aspects of human herpesvirus 6 infections. 38
25762531 2015
21
Clinical impact of primary infection with roseoloviruses. 38
25462439 2014
22
Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures. 38
25156011 2014
23
Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders. 38
25160553 2014
24
Detection of human herpesvirus 6 in cerebrospinal fluid of children with possible encephalitis. 38
25485059 2014
25
Roseola infantum and its causal human herpesviruses. 38
24673253 2014
26
Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion. 38
25705358 2014
27
Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection. 38
24380721 2014
28
[Case classification in measles surveillance system under the Two-level Logistic Model]. 38
24685039 2014
29
Mapping the telomere integrated genome of human herpesvirus 6A and 6B. 38
23648233 2013
30
The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection. 38
23769070 2013
31
Differentiating roseola infantum with pyuria from urinary tract infection. 38
23190314 2013
32
Animal models for human herpesvirus 6 infection. 38
23847599 2013
33
Human herpes virus type 6 can cause skin lesions at the BCG inoculation site similar to Kawasaki Disease. 38
23138414 2012
34
Catastrophic Kawasaki disease unresponsive to IVIG in a 3-month-old infant: a diagnostic and therapeutic challenge. 38
22929725 2012
35
Mutations of the SCN1A gene in acute encephalopathy. 38
22309220 2012
36
Age-specific sex-related differences in infections: a statistical analysis of national surveillance data in Japan. 38
22848753 2012
37
An epidemiological study of children with status epilepticus in Okayama, Japan: incidence, etiologies, and outcomes. 38
21741214 2011
38
Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. 38
21571030 2011
39
Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum. 38
21655829 2011
40
[Exanthema subitum - 3 day fever - HHV 6 infection - roseola infantum - 6th disease]. 38
21744571 2011
41
[HHV-6 infection and its clinical significance]. 38
21805894 2011
42
Improvement of intractable childhood epilepsy following acute viral infection. 38
20144516 2011
43
[Human herpesvirus-6 and human herpesvirus-7 (HHV-6, HHV-7)]. 38
21488335 2010
44
Impact of human herpes virus 6 in liver transplantation. 38
21161019 2010
45
Human herpesvirus 6B induces phenotypic maturation without IL-10 and IL-12p70 production in dendritic cells. 38
20500695 2010
46
Human herpesvirus-6 in patients with Crohn's disease. 38
20477816 2010
47
[Human herpesvirus 7]. 38
20353917 2010
48
A case of drug-induced hypersensitivity syndrome-like symptoms following HHV-6 encephalopathy. 38
19946201 2010
49
[Human herpesvirus 6]. 38
20304745 2010
50
Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. 38
19114298 2009

Variations for Exanthema Subitum

Expression for Exanthema Subitum

Search GEO for disease gene expression data for Exanthema Subitum.

Pathways for Exanthema Subitum

Pathways related to Exanthema Subitum according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 TARM1 KITLG ITGA2B IL2 FCGR3B FCGR3A
2
Show member pathways
13.62 THPO KITLG ITGA2B IL2 FCGR3B CD86
3
Show member pathways
13.36 KITLG FCGR3A CD86 CD80 CD40LG CD40
4
Show member pathways
13.31 THPO KITLG ITGA2B IL2 CD80 CD40LG
5
Show member pathways
13.22 KITLG ITGA2B IL2 CD86 CD80 CD40LG
6
Show member pathways
13.2 THPO KITLG IL2 CD80 CD40LG CD40
7
Show member pathways
12.79 IL2 CD86 CD80 CD40LG CD40 CD4
8
Show member pathways
12.62 THPO KITLG IL2 CD40LG CD40
9
Show member pathways
12.53 IL2 CD86 CD80 CD40LG CD40 CD4
10
Show member pathways
12.47 IL2 CD83 CD40LG CD4
11 12.45 KITLG IL2 CD83 CD46 CD40LG APEX1
12
Show member pathways
12.23 IL2 CD86 CD80 CD40LG CD40 CD4
13
Show member pathways
12.17 FCGR3B FCGR3A CD40LG CD40
14 12 CD86 CD80 CD40LG CD40 CD4
15
Show member pathways
11.99 THPO KITLG IL2 CD80 CD4
16 11.96 FCGR3A CD40LG CD40
17
Show member pathways
11.96 IL2 CD86 CD80 CD4
18
Show member pathways
11.92 FCGR3B FCGR3A CD40
19
Show member pathways
11.85 CD86 CD80 CD4
20 11.71 THPO KITLG ITGA2B CD7 CD4
21 11.7 IL2 CD7 CD4
22 11.66 IL2 CD83 CD4
23 11.64 CD86 CD80 CD4
24 11.63 THPO KITLG ITGA2B IL2
25 11.54 CD86 CD80 CD40LG CD40
26 11.48 IL2 FCGR3B FCGR3A CD86 CD80 CD40
27 11.37 IL2 CD86 CD80 CD4
28 11.31 CD40LG CD40 CD4
29 11.29 THPO KITLG ITGA2B IL2 CD86 CD83
30 11.17 IL2 CD86 CD80 CD40LG CD40
31 11.16 CD86 CD83 CD80 CD40LG CD40 CD4
32 10.92 THPO KITLG ITGA2B IL2 CD80 CD40LG

GO Terms for Exanthema Subitum

Cellular components related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.5 ITGA2B CD86 CD80 CD46 CD40LG CD40
2 external side of plasma membrane GO:0009897 9.23 ITGA2B FCGR3A CD86 CD83 CD80 CD40LG
3 membrane GO:0016020 10.17 TARM1 SCN1A KITLG ITGA2B FCGR3B FCGR3A
4 integral component of membrane GO:0016021 10.1 TARM1 SCN1A KITLG ITGA2B FCGR3B FCGR3A
5 plasma membrane GO:0005886 10 TARM1 SCN1A KITLG ITGA2B FCGR3B FCGR3A

Biological processes related to Exanthema Subitum according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.87 IL2 CD86 CD80 CD4
2 positive regulation of protein phosphorylation GO:0001934 9.8 THPO IL2 CD40 CD4
3 immune system process GO:0002376 9.8 TARM1 IL2 CD86 CD7 CD46 CD40
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 KITLG CD80 CD4
5 positive regulation of protein kinase B signaling GO:0051897 9.71 THPO KITLG CD86 CD80
6 viral entry into host cell GO:0046718 9.7 CD86 CD80 CD46
7 T cell costimulation GO:0031295 9.65 CD86 CD80 CD40LG
8 adaptive immune response GO:0002250 9.63 TARM1 IL2 CD86 CD7 CD46 CD4
9 positive regulation of endothelial cell apoptotic process GO:2000353 9.58 CD40LG CD40
10 positive regulation of kinase activity GO:0033674 9.58 IL2 CD4
11 positive regulation of leukocyte migration GO:0002687 9.56 KITLG ITGA2B
12 immune response GO:0006955 9.56 IL2 FCGR3B FCGR3A CD86 CD80 CD7
13 positive regulation of regulatory T cell differentiation GO:0045591 9.54 IL2 CD46
14 positive regulation of interleukin-10 production GO:0032733 9.54 CD83 CD46 CD40LG
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 IL2 CD40
16 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.5 CD86 CD80 CD4
17 regulation of immunoglobulin secretion GO:0051023 9.46 CD40LG CD40
18 positive regulation of hematopoietic stem cell proliferation GO:1902035 9.43 THPO KITLG
19 positive regulation of T cell proliferation GO:0042102 9.1 IL2 CD86 CD80 CD46 CD40LG CD4

Molecular functions related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 THPO KITLG IL2 CD40LG
2 3'-5' exonuclease activity GO:0008408 9.37 POLG APEX1
3 signaling receptor activity GO:0038023 9.35 CD86 CD7 CD46 CD40 CD4
4 coreceptor activity GO:0015026 9.33 CD86 CD80 CD4
5 IgG binding GO:0019864 9.32 FCGR3B FCGR3A
6 virus receptor activity GO:0001618 8.92 CD86 CD80 CD46 CD4

Sources for Exanthema Subitum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....