MCID: EXN001
MIFTS: 32

Exanthema Subitum

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Exanthema Subitum

MalaCards integrated aliases for Exanthema Subitum:

Name: Exanthema Subitum 12 43 15 17 71
Roseola Infantum 12 74
Sixth Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050495
ICD9CM 34 058.1
MeSH 43 D005077
SNOMED-CT 67 54385001
ICD10 32 B08.2
UMLS 71 C0015231

Summaries for Exanthema Subitum

Disease Ontology : 12 A viral infectious disease that results in infection in infants and children, located in skin, has material basis in Human herpesvirus 6 or has material basis in Human herpesvirus 7 and has symptom sudden high fever, and has symptom red rash that occurs first on the trunk then spreading to legs and neck.

MalaCards based summary : Exanthema Subitum, also known as roseola infantum, is related to iridocyclitis and drug allergy, and has symptoms including sudden high fever, red rash and exanthema. An important gene associated with Exanthema Subitum is SNORD94 (Small Nucleolar RNA, C/D Box 94). Affiliated tissues include skin, liver and brain.

Wikipedia : 74 Roseola, also known as sixth disease, is an infectious disease caused by certain types of virus. Most... more...

Related Diseases for Exanthema Subitum

Diseases related to Exanthema Subitum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 30.6 CD40LG CD4
2 drug allergy 30.5 CD40LG CD4
3 exanthem 10.7
4 febrile seizures 10.6
5 rubella 10.5
6 measles 10.4
7 granulocytopenia 10.4
8 encephalopathy 10.4
9 hemiplegia 10.4
10 visual epilepsy 10.3
11 encephalitis 10.3
12 seizure disorder 10.3
13 salpingitis 10.3 CD40LG CD4
14 cork-handlers' disease 10.3 CD40LG CD4
15 american histoplasmosis 10.3 CD40LG CD4
16 histoplasmosis 10.3 CD40LG CD4
17 syphilitic meningitis 10.3 CD40LG CD4
18 early yaws 10.3 CD40LG CD4
19 asymptomatic neurosyphilis 10.3 CD40LG CD4
20 latent syphilis 10.3 CD40LG CD4
21 gastroduodenitis 10.3 CD40LG CD4
22 duodenitis 10.3 CD40LG CD4
23 primary syphilis 10.3 CD40LG CD4
24 transient arthritis 10.3 CD40LG CD4
25 norwegian scabies 10.3 CD40LG CD4
26 necrotizing ulcerative gingivitis 10.3 CD40LG CD4
27 neuroretinitis 10.3 CD40LG CD4
28 tertiary neurosyphilis 10.3 CD40LG CD4
29 bacillary angiomatosis 10.3 CD40LG CD4
30 meningovascular neurosyphilis 10.3 CD40LG CD4
31 viral exanthem 10.3 CD40LG CD4
32 tertiary syphilis 10.3 CD40LG CD4
33 acute retinal necrosis syndrome 10.3 CD40LG CD4
34 optic papillitis 10.3 CD40LG CD4
35 opportunistic bacterial infectious disease 10.3 CD40LG CD4
36 cerebral lymphoma 10.3 CD40LG CD4
37 gastrointestinal tuberculosis 10.3 CD40LG CD4
38 cerebritis 10.3 CD40LG CD4
39 granulomatous hepatitis 10.3 CD40LG CD4
40 west nile encephalitis 10.3 CD40LG CD4
41 mikulicz disease 10.3 CD40LG CD4
42 autoimmune peripheral neuropathy 10.3 CD40LG CD4
43 congenital syphilis 10.3 CD40LG CD4
44 trichinosis 10.3 CD40LG CD4
45 mononeuritis of upper limb and mononeuritis multiplex 10.3 CD40LG CD4
46 mononeuritis multiplex 10.3 CD40LG CD4
47 granulomatous dermatitis 10.3 CD40LG CD4
48 secondary syphilis 10.3 CD40LG CD4
49 chancroid 10.3 CD40LG CD4
50 cat-scratch disease 10.3 CD40LG CD4

Graphical network of the top 20 diseases related to Exanthema Subitum:



Diseases related to Exanthema Subitum

Symptoms & Phenotypes for Exanthema Subitum

Symptoms:

12
  • sudden high fever
  • red rash

UMLS symptoms related to Exanthema Subitum:


exanthema

Drugs & Therapeutics for Exanthema Subitum

Search Clinical Trials , NIH Clinical Center for Exanthema Subitum

Cochrane evidence based reviews: exanthema subitum

Genetic Tests for Exanthema Subitum

Anatomical Context for Exanthema Subitum

The Foundational Model of Anatomy Ontology organs/tissues related to Exanthema Subitum:

19
Skin

MalaCards organs/tissues related to Exanthema Subitum:

40
Skin, Liver, Brain, Bone Marrow, Bone, Heart, Testes

Publications for Exanthema Subitum

Articles related to Exanthema Subitum:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Inherited chromosomally integrated human herpesvirus-6 in a patient with XIAP deficiency. 61
32424944 2020
2
Current understanding of human herpesvirus 6 (HHV-6) chromosomal integration. 61
32044155 2020
3
HHV-6: an unusual cause of cerebellar ataxia. 61
32188617 2020
4
The rash with mucosal ulceration. 61
32197747 2020
5
Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A. 61
31972018 2020
6
HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells. 61
31521763 2019
7
Clinical Characteristics of Primary HHV-6B Infection in Children Visiting the Emergency Room. 61
31261358 2019
8
HHV-6 Infection in an Immunocompetent Patient with Multi-organ Failure. 61
31646134 2019
9
Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress. 61
30427305 2019
10
Entry of betaherpesviruses. 61
31439151 2019
11
An evaluation of HHV-6 as an etiologic agent in Hodgkin lymphoma and brain cancer using IARC criteria for oncogenicity. 61
31709003 2019
12
Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case-control study in a referral hospital in Zambia. 61
30011348 2018
13
Oral propranolol for infantile hemangiomas beyond the proliferative phase. 61
30051930 2018
14
Chromosomally integrated human herpesvirus 6 in the Japanese population. 61
29905966 2018
15
[Encephalopathy due to human herpesvirus 6 infection as exanthema subitum complication]. 61
29557623 2018
16
Unique cell tropism of HHV-6B in an infantile autopsy case of primary HHV-6B encephalitis. 61
29582466 2018
17
The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola. 61
29489601 2018
18
Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab. 61
29785130 2018
19
Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis. 61
28342868 2017
20
Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult. 61
28545483 2017
21
Update on infections with human herpesviruses 6A, 6B, and 7. 61
27773488 2017
22
[Serological and molecular methods in diagnostics of primary acute hepatitis caused with human herpesvirus type 6 - a case report]. 61
30351623 2017
23
Human Herpesviruses 6A, 6B, and 7. 61
27337451 2016
24
Focal Coxsackie virus B5 encephalitis with synchronous seizure cluster and eruption: Infantile case. 61
26711006 2016
25
Predicting the characteristics of the aetiological agent for Kawasaki disease from other paediatric infectious diseases in Japan. 61
26201398 2016
26
Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia. 61
27980872 2016
27
Human herpesvirus-6 infection-associated acute encephalopathy without skin rash. 61
25582898 2015
28
Laboratory and clinical aspects of human herpesvirus 6 infections. 61
25762531 2015
29
Clinical impact of primary infection with roseoloviruses. 61
25462439 2014
30
Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures. 61
25156011 2014
31
Detection of human herpesvirus 6 in cerebrospinal fluid of children with possible encephalitis. 61
25485059 2014
32
Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders. 61
25160553 2014
33
Roseola infantum and its causal human herpesviruses. 61
24673253 2014
34
Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion. 61
25705358 2014
35
Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection. 61
24380721 2014
36
[Case classification in measles surveillance system under the Two-level Logistic Model]. 61
24685039 2014
37
Mapping the telomere integrated genome of human herpesvirus 6A and 6B. 61
23648233 2013
38
The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection. 61
23769070 2013
39
Differentiating roseola infantum with pyuria from urinary tract infection. 61
23190314 2013
40
Animal models for human herpesvirus 6 infection. 61
23847599 2013
41
Human herpes virus type 6 can cause skin lesions at the BCG inoculation site similar to Kawasaki Disease. 61
23138414 2012
42
Catastrophic Kawasaki disease unresponsive to IVIG in a 3-month-old infant: a diagnostic and therapeutic challenge. 61
22929725 2012
43
Mutations of the SCN1A gene in acute encephalopathy. 61
22309220 2012
44
Age-specific sex-related differences in infections: a statistical analysis of national surveillance data in Japan. 61
22848753 2012
45
An epidemiological study of children with status epilepticus in Okayama, Japan: incidence, etiologies, and outcomes. 61
21741214 2011
46
Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. 61
21571030 2011
47
Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum. 61
21655829 2011
48
[Exanthema subitum - 3 day fever - HHV 6 infection - roseola infantum - 6th disease]. 61
21744571 2011
49
[HHV-6 infection and its clinical significance]. 61
21805894 2011
50
Improvement of intractable childhood epilepsy following acute viral infection. 61
20144516 2011

Variations for Exanthema Subitum

Expression for Exanthema Subitum

Search GEO for disease gene expression data for Exanthema Subitum.

Pathways for Exanthema Subitum

GO Terms for Exanthema Subitum

Cellular components related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.32 SNORD94 SNORD83A SNORD79 SNORD51 SNORD42A SNORD41

Biological processes related to Exanthema Subitum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA processing GO:0006396 9.32 SNORD94 SNORD83A SNORD79 SNORD51 SNORD42A SNORD41
2 positive regulation of interleukin-10 production GO:0032733 9.16 CD46 CD40LG
3 positive regulation of T cell proliferation GO:0042102 9.13 CD46 CD40LG CD4

Sources for Exanthema Subitum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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