MCID: EXC003
MIFTS: 33

Excessive Tearing

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Excessive Tearing

MalaCards integrated aliases for Excessive Tearing:

Name: Excessive Tearing 12 15 70
Lacrimal Apparatus Diseases 44 70
Epiphora 12 32
Excessive Tear Production 12
Watering Eye 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13757
ICD9CM 34 375.2
MeSH 44 D007766
NCIt 50 C50552
SNOMED-CT 67 49393005
ICD10 32 H04.2
UMLS 70 C0022904 C0152227

Summaries for Excessive Tearing

MalaCards based summary : Excessive Tearing, also known as lacrimal apparatus diseases, is related to early-onset glaucoma and keratitis, hereditary, and has symptoms including visual disturbance, eye manifestations and discharge from eye. An important gene associated with Excessive Tearing is CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1), and among its related pathways/superpathways is Arf6 signaling events. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and breast.

Related Diseases for Excessive Tearing

Diseases related to Excessive Tearing via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 early-onset glaucoma 31.9 MYOC CYP1B1
2 keratitis, hereditary 29.9 MYOC FOXC1 CYP1B1
3 eye disease 29.3 TSHR MYOC FOXC1 CYP1B1
4 open-angle glaucoma 29.1 WDR36 MYOC LTBP2 FOXC1 CYP1B1
5 lacrimal apparatus disease 11.3
6 bell's palsy 11.3
7 aplasia of lacrimal and salivary glands 11.1
8 rapp-hodgkin syndrome 11.0
9 corneal dystrophy, epithelial basement membrane 11.0
10 tyrosinemia, type ii 11.0
11 tyrosinemia 11.0
12 cluster headache 11.0
13 dacryocystitis 11.0
14 epiphora due to insufficient drainage 11.0
15 epiphora due to excess lacrimation 11.0
16 dacryocystocele 10.9
17 epithelial recurrent erosion dystrophy 10.9
18 dyskeratosis congenita, autosomal dominant 1 10.9
19 lacrimoauriculodentodigital syndrome 10.9
20 dyskeratosis congenita, autosomal dominant 3 10.9
21 acute canaliculitis 10.9
22 dacryoadenitis 10.4
23 glaucoma 3, primary infantile, b 10.3 LTBP2 CYP1B1
24 glaucoma 1, open angle, a 10.2 MYOC CYP1B1
25 ptosis 10.2
26 conjunctivitis 10.2
27 acute closed-angle glaucoma 10.2 MYOC CYP1B1
28 facial paralysis 10.2
29 chronic dacryocystitis 10.2
30 peripheral retinal degeneration 10.1 WDR36 MYOC
31 ectropion 10.1
32 traumatic glaucoma 10.1 MYOC LTBP2 CYP1B1
33 geleophysic dysplasia 3 10.1 LTBP3 LTBP2
34 axenfeld-rieger syndrome, type 2 10.1 WDR36 FOXC1
35 corneal edema 10.1 MYOC LTBP2 CYP1B1
36 geleophysic dysplasia 10.1 LTBP3 LTBP2
37 glaucoma 1, open angle, d 10.1 MYOC LTBP2 CYP1B1
38 lacrimal duct defect 10.1
39 keratoconjunctivitis sicca 10.1
40 squamous cell papilloma 10.1
41 papilloma 10.1
42 conjunctivochalasis 10.1
43 geleophysic dysplasia 1 10.1 LTBP3 LTBP2
44 witkop syndrome 10.1 LTBP3 LTBP2
45 primary angle-closure glaucoma 10.1 MYOC CYP1B1
46 geleophysic dysplasia 2 10.1 LTBP3 LTBP2
47 anterior segment dysgenesis 1 10.1 FOXC1 CYP1B1
48 autosomal recessive cutis laxa type i 10.1 LTBP3 LTBP2
49 microphthalmia, isolated 2 10.1 WDR36 MYOC CYP1B1
50 steroid-induced glaucoma 10.1 WDR36 MYOC CYP1B1

Graphical network of the top 20 diseases related to Excessive Tearing:



Diseases related to Excessive Tearing

Symptoms & Phenotypes for Excessive Tearing

UMLS symptoms related to Excessive Tearing:


visual disturbance; eye manifestations; discharge from eye; dacryops; watery eyes

Drugs & Therapeutics for Excessive Tearing

Drugs for Excessive Tearing (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Hormones Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Gastrointestinal Agents Phase 4
12 Antiemetics Phase 4
13 Methylprednisolone Acetate Phase 4
14 Neuroprotective Agents Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Protective Agents Phase 4
17 Ophthalmic Solutions Phase 4
18 Pharmaceutical Solutions Phase 4
19 Anesthetics Phase 4
20 Anesthetics, Local Phase 4
21 Proxymetacaine Phase 4
22 Lubricant Eye Drops Phase 2, Phase 3
23 Cyclosporins Phase 2, Phase 3
24
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
25
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
26
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 2 53-43-0 5881
27 Neurotransmitter Agents Phase 2
28 abobotulinumtoxinA Phase 2
29 Cholinergic Agents Phase 2
30 Botulinum Toxins, Type A Phase 2
31 Botulinum Toxins Phase 2
32 Adjuvants, Immunologic Phase 2
33 DHEA (Dehydroepiandrosterone) Phase 2
34 Androgens Phase 2
35
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
36
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
37 BB 1101 Phase 1
38
Iodine Approved, Investigational 7553-56-2 807
39
Lidocaine Approved, Vet_approved 137-58-6 3676
40
Cadexomer iodine Experimental 94820-09-4
41 Emollients
42 Benoxinate
43 Hemostatics

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation Completed NCT01010659 Phase 4
2 The Role of Anterior Segment Optical Coherence Tomography in Management of Acquired Punctal Stenosis Completed NCT04318652 Phase 4 Methylprednisolone eyedrops
3 Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort Recruiting NCT04229771 Phase 4 Proparacaine Hydrochloride ophthalmic solution, USP 0.5%;Balanced salt solution
4 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Unknown status NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
5 Topical Cyclosporine-A for Management of Epiphora in Eyes With Acquired Punctal Stenosis Completed NCT04637633 Phase 2, Phase 3 topical 0.05% CsA (Restasis®, Allergan Inc, Irvine, California)twice daily dose,
6 Determination of the Optimum Delivery Route for the Intraglandular Administration of Botulinum Toxin A in Patients With Refractory Epiphora Completed NCT01282541 Phase 2 Botulinum Toxin Type A;Botulinum Toxin Type A
7 Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome Completed NCT00001598 Phase 2 Dehydroepiandrosterone
8 Improving Epiphora & Ptosis With Bupivacaine Suspended NCT03266081 Phase 2 0.75% bupivacaine
9 A Double-Blind Study Evaluating the Safety and Efficacy of Cyclosporine Ophthalmic Emulsion 0.05% [Restasis] in Subjects With Epiphora Secondary to Docetaxel [Taxotere] Treatment for Various Cancers Withdrawn NCT00824811 Phase 2 Cyclosporine Eye Drops (Restasis);Lubricant Eye Drops (Refresh Endura™);Fluorometholone Eye Drops (FML Forte®)
10 A Double Blind Interventional Study of the Efficacy of Topical Eye Treatment in the Prevention of Docetaxel Induced Dacryostenosis Completed NCT00266838 Phase 1 Maxidex; Lacrystat
11 Evaluation of Acquired Punctal Stenosis by Using Anterior Segment Optical Coherence Tomography (AS-OCT) Unknown status NCT03498144
12 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome (OCT) Unknown status NCT02849093
13 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
14 Long Term Follow up of Nasolacrimal Intubation in Adults With Mild Epiphora Completed NCT00706251
15 The Sinopsys Lacrimal Stent Used During the Repair of the Lacrimal System in Patients With Epiphora Completed NCT02240615 Early Phase 1
16 Adult Encysted Dacryocystocele: Prevalence Among Patients With Epiphora and Its Management Completed NCT04240938
17 A Simple Surgical Approach for the Management of Acquired Severe Lower Punctual Stenosis Completed NCT03731143
18 The Efficacy of Punctal Dilatation With Insertion of Perforated Punctal Plugs for the Management of Acquired Punctal Stenosis Due to Allergic Conjunctivitis Completed NCT02503956
19 Lacrimal Drainage Resistance Study Completed NCT01766232
20 Symptomatic Acquired Lacrimal Passage Obstruction: Clinical Evaluation of the Level of Obstruction in Adult Patients of Upper Egypt Completed NCT04240431
21 Lacrimal Sac Dacryoliths (86 Samples): Chemical and Mineralogic Analyses Completed NCT01826734
22 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Completed NCT03706443
23 Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction Recruiting NCT03705000
24 Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa : Study of a Handheld in Vivo Confocal Microscope and of a Fluorescent in Vivo Confocal Microscope Recruiting NCT02386774
25 A Comparison Between Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty vs Conventional Triangular Three-snip Punctoplasty for Treatment of Lower Punctal Stenosis Active, not recruiting NCT04680078

Search NIH Clinical Center for Excessive Tearing

Cochrane evidence based reviews: lacrimal apparatus diseases

Genetic Tests for Excessive Tearing

Anatomical Context for Excessive Tearing

MalaCards organs/tissues related to Excessive Tearing:

40
Eye, Thyroid, Breast, Bone, Lung

Publications for Excessive Tearing

Articles related to Excessive Tearing:

(show top 50) (show all 90)
# Title Authors PMID Year
1
Effect of Bandage Contact Lens Exchange on Pain and Healing After Photorefractive Keratectomy-A Randomized Control Trial. 61
33492010 2021
2
A New Screening Questionnaire to Identify Patients With Dry Eye With a High Likelihood of Having Sjögren Syndrome. 61
33055548 2021
3
The Epidemiological and Clinical Findings from the Latvian Registry of Primary Congenital Glaucoma and Evaluation of Prognostic Factors. 61
33430228 2021
4
Initial Manifestation of Orbital Lymphomas: The Role of Early Diagnosis. 61
33645951 2021
5
Central retinal artery and vein occlusion as a complication of persistent hyaloid artery - a case report. 61
33143669 2020
6
Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production. 61
33233559 2020
7
[Disorders of the Lacrimal Apparatus, Part 2: Basics of Therapy]. 61
32314340 2020
8
Computer Vision Syndrome Among Health Sciences Students in Saudi Arabia: Prevalence and Risk Factors. 61
32226662 2020
9
High-grade spheno-orbital meningioma in patients with systemic lupus erythematosus: Two case reports and literature review. 61
33194300 2020
10
Intrapalpebral Extending Dysesthetic Bleb Revision with Fibrin Glue. 61
32581467 2020
11
Lacrimal drainage system stenosis associated with Trastuzumab emtansine (Kadcyla®, T-DM1) administration: a case report. 61
31387552 2019
12
Management of Congenital Nasolacrimal Duct Obstruction with Probing, Experience in a Mexican Eye Center. 61
32792696 2019
13
Clinical indicators of dry eye severity nursing outcome in intensive care unit. 61
31664409 2019
14
Linear Polyethylenimine-DNA Nanoconstruct for Corneal Gene Delivery. 61
30699061 2019
15
Congenital Nasolacrimal Duct Obstruction (CNLDO): A Review. 61
30360371 2018
16
A Novel Treatment for Nasolacrimal Air Regurgitation Into the Eye With CPAP: The Total Face Mask. 61
30092899 2018
17
Intraoperative Patient Experience and Postoperative Visual Quality After SMILE and LASIK in a Randomized, Paired-Eye, Controlled Study. 61
29425387 2018
18
Improved cookstoves and their effect on carbon monoxide levels in San Lucas Tolimán, Guatemala. 61
29380623 2018
19
Intra-arterial chemotherapy as second-line treatment for advanced retinoblastoma: A 2-year single-center study in China. 61
29516970 2018
20
Seeking Optimal Management for Radioactive Iodine Therapy-induced Adverse Effects. 61
28966960 2017
21
Outcome of intra-arterial chemotherapy for retinoblastoma and its influencing factors: a retrospective study. 61
27874261 2017
22
Probing for congenital nasolacrimal duct obstruction. 61
28700811 2017
23
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. 61
28924439 2017
24
Atopic keratoconjunctivitis with corneal ulcer. Case report. 61
29450349 2016
25
[Oculorrhea after facial fracture and anterior skull base fracture]. 61
26928686 2016
26
Radioactive Iodine Administration Is Associated with Persistent Related Symptoms in Patients with Differentiated Thyroid Cancer. 61
27867395 2016
27
Supernumerary punctum: an unusual case of seeing double. 61
25943682 2015
28
[Laryngeoscopic approach for Lacrimal Apparatus Diseases]. 61
26591016 2015
29
Correlations between eyelid tumors and tear lipocalin, lysozyme and lactoferrin concentrations in postmenopausal women. 61
25914748 2015
30
Bilateral simultaneous pyogenic granuloma after perforated punctal plug insertion. 61
24195991 2014
31
Ectropion, entropion, trichiasis. 61
24172761 2013
32
Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4-year-old girl. 61
23606421 2013
33
The association of carotid cavernous fistula with Graves' ophthalmopathy. 61
23571267 2013
34
Prevalence of excessive tearing in women with early breast cancer receiving adjuvant docetaxel-based chemotherapy. 61
23650421 2013
35
Epiphora and canalicular stenosis associated with adjuvant docetaxel in early breast cancer: is excessive tearing clinically important? 61
23650413 2013
36
Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle. 61
23530766 2013
37
Epiphora after radioactive iodine ablation for thyroid cancer. 61
22946448 2013
38
Clinical and ultrasonographic findings of some ocular conditions in sheep and goats. 61
26623306 2013
39
Molecular Diagnostics and Genetic Counseling in Primary Congenital Glaucoma. 61
26997777 2013
40
Rare pediatric rhino-orbital infection caused by Saksenaea vasiformis. 61
23001544 2012
41
Crocodile tears syndrome after vestibular schwannoma surgery. 61
22304448 2012
42
Index of Suspicion. Case 1: Irritability and signs of peritonitis in a neonate. Case 2: Red eye, excessive tearing, photophobia, irritability, and splenomegaly in an infant. Case 3: 2-year-old girl who has cough, right pulmonary abnormalities. 61
22383516 2012
43
The importance of autonomic symptoms in trigeminal neuralgia. Clinical article. 61
21568653 2011
44
Clinical and antiviral efficacy of an ophthalmic formulation of dexamethasone povidone-iodine in a rabbit model of adenoviral keratoconjunctivitis. 61
20702820 2011
45
Use of adjunctive mitomycin C in external dacryocystorhinostomy surgery compared with surgery alone in patients with nasolacrimal duct obstruction: A prospective, double-masked, randomized, controlled trial. 61
24683236 2009
46
Acute laryngeal and bronchial obstruction after CS (o-chlorobenzylidenemalononitrile) gas inhalation. 61
18365225 2009
47
A new modification in the porous polyethylene-coated lester jones tube. 61
19229741 2009
48
Exercise-induced asthma may be associated with diminished sweat secretion rates in humans. 61
18641089 2008
49
Graves ophthalmopathy after radiation treatment of thyroid cancer. 61
18558592 2008
50
[Basic diagnostics of tear duct diseases]. 61
18373096 2008

Variations for Excessive Tearing

Expression for Excessive Tearing

Search GEO for disease gene expression data for Excessive Tearing.

Pathways for Excessive Tearing

Pathways related to Excessive Tearing according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.15 TSHR IPCEF1

GO Terms for Excessive Tearing

Biological processes related to Excessive Tearing according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 8.62 FOXC1 CYP1B1

Molecular functions related to Excessive Tearing according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 LTBP3 LTBP2

Sources for Excessive Tearing

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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