MCID: EXR007
MIFTS: 24

Exercise-Induced Anaphylaxis

Categories: Rare diseases

Aliases & Classifications for Exercise-Induced Anaphylaxis

MalaCards integrated aliases for Exercise-Induced Anaphylaxis:

Name: Exercise-Induced Anaphylaxis 20
Exercise Anaphylaxis 70

Classifications:



External Ids:

UMLS 70 C0344183

Summaries for Exercise-Induced Anaphylaxis

GARD : 20 Exercise-induced anaphylaxis (EIAn) is a rare disorder in which anaphylaxis occurs in association with physical activity. Food-dependent exercise-induced anaphylaxis is a subset of this disorder in which symptoms develop if exertion takes place within a few hours of eating a specific food. In the case of food-dependent exercise-induced anaphylaxis, neither the food nor the exercise alone is enough to cause anaphylaxis. Vigorous forms of physical activity, such as jogging, are more commonly associated with exercise-induced anaphylaxis, although lower levels of exertion (eg, walking and yard work) are also capable of triggering attacks. However, the condition can be unpredictable; a given level of exercise may cause an episode on one occasion but not another. Symptoms of exercise-induced anaphylaxis may include itching, hives (urticaria), flushing, extreme fatigue, and wheezing. Affected individuals may also experience nausea, abdominal cramping, and diarrhea. Continuing the physical activity causes the symptoms to become worse. However, if the individual stops the activity when the symptoms first appear, there is usually improvement within minutes. In most cases, these conditions are sporadic, though familial cases have been reported.

MalaCards based summary : Exercise-Induced Anaphylaxis, also known as exercise anaphylaxis, is related to urticaria and wheat allergy. An important gene associated with Exercise-Induced Anaphylaxis is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Immune response NFAT in immune response and Interleukin-4 and 13 signaling. Affiliated tissues include heart and skin.

Wikipedia : 73 Exercise-induced anaphylaxis (EIA, EIAn, EIAs) is a rare condition in which anaphylaxis, a serious or... more...

Related Diseases for Exercise-Induced Anaphylaxis

Diseases related to Exercise-Induced Anaphylaxis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 urticaria 30.9 IL18 IGHE ENPP3
2 wheat allergy 30.9 IGHE ENPP3
3 food allergy 30.5 IGHE FLG ENPP3
4 allergic disease 30.3 IL18 IGHE
5 chronic urticaria 30.2 IGHE ENPP3
6 allergic rhinitis 30.1 IL18 IGHE
7 dermatitis, atopic 30.0 IL18 IGHE FLG
8 latex allergy 29.4 IL18 IGHE FLG
9 angioedema 10.7
10 cholinergic urticaria 10.6
11 syncope 10.5
12 exanthem 10.3
13 rhinitis 10.2
14 cold urticaria 10.2
15 ige responsiveness, atopic 10.1
16 physical urticaria 10.1
17 intermittent asthma 10.1
18 exercise-induced bronchoconstriction 10.1
19 common cold 10.1
20 immunoglobulin g deficiency 10.1 IGHE CD79A
21 ocular toxoplasmosis 10.1 IGHE CD79A
22 anisakiasis 10.1 IGHE CD79A
23 clonorchiasis 10.1 IGHE CD79A
24 strongyloidiasis 10.1 IGHE CD79A
25 penicillin allergy 10.0 IL18 IGHE
26 cysticercosis 10.0 IL18 IGHE
27 amoxicillin allergy 10.0 IGHE ENPP3
28 immunodeficiency with hyper-igm, type 1 10.0 IGHE CD79A
29 peach allergy 10.0 IGHE ENPP3
30 milk allergy 10.0 IGHE CD79A
31 dermatographia 10.0 IGHE ENPP3
32 congenital toxoplasmosis 10.0 IL18 CD79A
33 beta-lactam allergy 10.0 IGHE ENPP3
34 drug allergy 10.0 IGHE ENPP3
35 extrinsic allergic alveolitis 10.0 IL18 IGHE
36 bacteriuria 10.0 IL18 CD79A
37 pollen allergy 10.0 IGHE ENPP3
38 proteasome-associated autoinflammatory syndrome 1 10.0 IL18 IGHE
39 respiratory allergy 10.0 IGHE ENPP3
40 atrial standstill 1 10.0
41 ichthyosis vulgaris 10.0
42 immunoglobulin e concentration, serum 10.0
43 familial mediterranean fever 10.0
44 helicobacter pylori infection 10.0
45 ventricular fibrillation, paroxysmal familial, 1 10.0
46 leptin deficiency or dysfunction 10.0
47 apple allergy 10.0
48 chronic spontaneous urticaria 10.0
49 brucellosis 10.0
50 ichthyosis 10.0

Graphical network of the top 20 diseases related to Exercise-Induced Anaphylaxis:



Diseases related to Exercise-Induced Anaphylaxis

Symptoms & Phenotypes for Exercise-Induced Anaphylaxis

Drugs & Therapeutics for Exercise-Induced Anaphylaxis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Detection of Clonal Mast Cell Disorders Among Patients With Exercise-induced Anaphylaxis Unknown status NCT01326741
2 The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women Unknown status NCT01314573

Search NIH Clinical Center for Exercise-Induced Anaphylaxis

Genetic Tests for Exercise-Induced Anaphylaxis

Anatomical Context for Exercise-Induced Anaphylaxis

MalaCards organs/tissues related to Exercise-Induced Anaphylaxis:

40
Heart, Skin

Publications for Exercise-Induced Anaphylaxis

Articles related to Exercise-Induced Anaphylaxis:

(show top 50) (show all 489)
# Title Authors PMID Year
1
Exercise-induced anaphylaxis. 61 20
25841550 2015
2
Identification of peroxidase-1 and beta-glucosidase as cross-reactive wheat allergens in grass pollen-related wheat allergy. 61
33616048 2021
3
Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp. 61
33686124 2021
4
IgE-mediated food allergy throughout life 61
32892543 2021
5
Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis. 61
33386792 2021
6
A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. 61
33604274 2021
7
Food Dependent Exercise-Induced Anaphylaxis in pediatric age. Can we trust the oral food challenge with exercise and acetylsalicylic acid? 61
33682838 2020
8
Novel insights regarding anaphylaxis in children - With a focus on prevalence, diagnosis, and treatment. 61
32519391 2020
9
Summation anaphylaxis: A challenging diagnosis. 61
33236417 2020
10
Design, Assessment, and Validation of a Questionnaire to Estimate Food-Dependent Exercise-Induced Anaphylaxis Prevalence in Latin American Population. 61
33260469 2020
11
Food allergies and food-induced anaphylaxis: Role of cofactors. 61
33181008 2020
12
Profilins and Food Dependent Exercise-Induced Anaphylaxis. 61
33074151 2020
13
A Case of Pork-cat Syndrome That Developed as Food-dependent Exercise-induced Anaphylaxis. 61
32618350 2020
14
Food-dependent exercise-induced anaphylaxis to soybean: Gly m 5 and Gly m 6 as causative allergen components. 61
32670463 2020
15
Gut microbiome alterations in patients with wheat-dependent exercise-induced anaphylaxis. 61
32388491 2020
16
Japanese guidelines for food allergy 2020. 61
33289637 2020
17
Reverse Takotsubo Cardiomyopathy (rTTC) after a Severe Almond-dependent, Exercise-induced Anaphylaxis. 61
32732187 2020
18
Clinical Management of Exercise-Induced Anaphylaxis and Cholinergic Urticaria. 61
32620433 2020
19
Oral mite anaphylaxis: who, when, and how? 61
31977450 2020
20
Food Allergy from Infancy Through Adulthood. 61
32499034 2020
21
Kidney-bean (Phaseolus Vulgaris) Dependent, Exercise-induced Anaphylaxis in Patients Comorbid with Mugwort (Artemisia Vulgaris) Pollinosis. 61
32506984 2020
22
Genetic variation at the interleukin-18 locus is associated with wheat-dependent exercise-induced anaphylaxis in the Han Chinese population. 61
32045661 2020
23
Exercise-Induced Anaphylaxis in Third Trimester Pregnancy. 61
32146164 2020
24
Clinical Characteristics and Proposed Wheat-Cofactor Challenge Protocol with a High Diagnostic Yield in Adult-Onset IgE-Mediated Wheat Allergy. 61
33061463 2020
25
[CHARACTERISTICS OF THE SYMPTOMS DURING FOOD AND EXERCISE PROVOCATION TESTS IN PATIENTS AFTER ORAL IMMUNOTHERAPY: COMPARISON WITH FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS]. 61
32051367 2020
26
Wheat-dependent exercise-induced anaphylaxis in Chinese people: a clinical research on 33 cases with antigenic analysis of wheat proteins. 61
31267575 2020
27
Detection of wheat allergens using 2D Western blot and mass spectrometry. 61
31634755 2020
28
Modified acid-PAGE method for rapid screening and phenotyping of wheat gliadin mutant lines. 61
32322542 2020
29
Adult-onset IgE-mediated food allergy at a Winnipeg allergy clinic: a case series. 61
33014083 2020
30
Differences in omega-5-gliadin allergy: East versus West. 61
32099827 2020
31
Dust mite ingestion-associated, exercise-induced anaphylaxis: a case report and literature review. 61
31911805 2020
32
Evaluation of the allergenicity of ω5-gliadin-deficient Hokushin wheat (1BS-18) in a wheat allergy rat model. 61
31720438 2019
33
A challenging diagnosis of exercise-related transient abdominal pain. 61
31311236 2019
34
Anti-gluten IgE titer is associated with severity of provocation test-evoked symptoms in wheat-dependent exercise-induced anaphylaxis. 61
31176598 2019
35
Food-dependent exercise-induced anaphylaxis due to pickled Japanese apricot. 61
30928184 2019
36
Friend or foe: food-dependent exercise-induced anaphylaxis associated with acute coronary syndrome aggravated by adrenaline and aspirin: a case report. 61
31660504 2019
37
Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study. 61
31332982 2019
38
Food-dependent exercise-induced anaphylaxis with sensitization to tomato: Diagnostic approach involving food-exercise challenge. 61
31228627 2019
39
A Case of Possible Monosodium Glutamate-Dependent, Exercise-Induced Anaphylaxis. 61
31602350 2019
40
Diagnosis and prevention of food-dependent exercise-induced anaphylaxis. 61
31305164 2019
41
Food-dependent exercise-induced reactions: lessons from a 15-year retrospective study. 61
30661174 2019
42
Wheat Allergy in Children: A Comprehensive Update. 61
31340608 2019
43
Analysis of allergens in corn-dependent exercise-induced anaphylaxis. 61
30978405 2019
44
Idiopathic anaphylaxis. 61
31002196 2019
45
[A case of freshwater fish-dependent exercise-induced anaphylaxis]. 61
31262115 2019
46
Food-dependent exercise-induced anaphylaxis. 61
30893086 2019
47
Series of 12 cases of wheat-dependent exercise-induced allergy in Aragon, Spain. 61
30651196 2019
48
Food dependent exercise induced anaphylaxis triggered by inhaled antigen. 61
30803849 2019
49
Favorable Prognosis of Wheat Allergy in Adults. 61
31017108 2019
50
Exercise-induced anaphylaxis: causes, consequences, and management recommendations. 61
30601082 2019

Variations for Exercise-Induced Anaphylaxis

Expression for Exercise-Induced Anaphylaxis

Search GEO for disease gene expression data for Exercise-Induced Anaphylaxis.

Pathways for Exercise-Induced Anaphylaxis

Pathways related to Exercise-Induced Anaphylaxis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 IL18 IGHE CD79A
2 11.21 IL18 IGHE
3
Show member pathways
10.98 IGHE CD79A

GO Terms for Exercise-Induced Anaphylaxis

Cellular components related to Exercise-Induced Anaphylaxis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 IGHE ENPP3 CD79A

Biological processes related to Exercise-Induced Anaphylaxis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell receptor signaling pathway GO:0050853 8.62 IGHE CD79A

Sources for Exercise-Induced Anaphylaxis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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