MCID: EXR008
MIFTS: 20

Exercise-Induced Malignant Hyperthermia

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Exercise-Induced Malignant Hyperthermia

MalaCards integrated aliases for Exercise-Induced Malignant Hyperthermia:

Name: Exercise-Induced Malignant Hyperthermia 58
Exertional Heat Stroke 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 T88.3
Orphanet 58 ORPHA466650

Summaries for Exercise-Induced Malignant Hyperthermia

MalaCards based summary : Exercise-Induced Malignant Hyperthermia, also known as exertional heat stroke, is related to stroke, ischemic and metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration. An important gene associated with Exercise-Induced Malignant Hyperthermia is RYR1 (Ryanodine Receptor 1). The drug Dantrolene has been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and skeletal muscle.

Related Diseases for Exercise-Induced Malignant Hyperthermia

Diseases related to Exercise-Induced Malignant Hyperthermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 10.9
2 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.8
3 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.8
4 acute kidney failure 10.6
5 acute liver failure 10.6
6 ocular motor apraxia 10.5
7 disseminated intravascular coagulation 10.5
8 liver disease 10.5
9 kidney disease 10.4
10 malignant hyperthermia 10.3
11 toxic shock syndrome 10.3
12 ataxia and polyneuropathy, adult-onset 10.2
13 metabolic acidosis 10.2
14 myopathy 10.2
15 hypokalemia 10.2
16 ichthyosis vulgaris 10.0
17 hypophosphatemia 10.0
18 ichthyosis 10.0
19 malignant hyperthermia susceptibility 10.0
20 cardiac arrhythmia 10.0
21 cardiac conduction defect 10.0
22 malignant hyperthermia 1 10.0
23 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
24 hypocalcemia, autosomal dominant 1 10.0
25 anhidrosis 10.0
26 adult respiratory distress syndrome 10.0
27 pulmonary edema 10.0
28 hepatic coma 10.0
29 diarrhea 10.0
30 hepatic encephalopathy 10.0
31 eclampsia 10.0
32 prostatitis 10.0
33 impotence 10.0
34 hyperuricemia 10.0
35 hepatitis 10.0
36 bilirubin metabolic disorder 10.0
37 ischemia 10.0
38 lactic acidosis 10.0
39 hyperglycemia 10.0
40 multiple chemical sensitivity 10.0
41 compartment syndrome 10.0
42 myocarditis 10.0
43 subacute delirium 10.0
44 47,xyy 10.0
45 cytokine deficiency 10.0
46 encephalopathy 10.0
47 syncope 10.0

Graphical network of the top 20 diseases related to Exercise-Induced Malignant Hyperthermia:



Diseases related to Exercise-Induced Malignant Hyperthermia

Symptoms & Phenotypes for Exercise-Induced Malignant Hyperthermia

Drugs & Therapeutics for Exercise-Induced Malignant Hyperthermia

Drugs for Exercise-Induced Malignant Hyperthermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dantrolene Approved, Investigational Phase 3 7261-97-4 2952 6914273

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 3, Multi-Center, Double-Blind, Randomized, 2-Arm, Parallel Study to Assess the Efficacy and Safety of Ryanodex (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS) Completed NCT03600376 Phase 3 Ryanodex and Standard of Care
2 Phase 2, Single-Site, Open-Label, Randomized, 2-Arm Parallel Study to Assess the Efficacy and Safety of Ryanodex® (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS) Completed NCT02513095 Phase 2 Dantrolene sodium for injectable suspension
3 Functional Neural Connectivity at Rest, as a Diagnostic Tool for Intolerance to Heat and Return to Duty After Exertional Heat Stroke Unknown status NCT02498158

Search NIH Clinical Center for Exercise-Induced Malignant Hyperthermia

Genetic Tests for Exercise-Induced Malignant Hyperthermia

Anatomical Context for Exercise-Induced Malignant Hyperthermia

MalaCards organs/tissues related to Exercise-Induced Malignant Hyperthermia:

40
Liver, Kidney, Skeletal Muscle, Colon, Neutrophil

Publications for Exercise-Induced Malignant Hyperthermia

Articles related to Exercise-Induced Malignant Hyperthermia:

(show top 50) (show all 306)
# Title Authors PMID Year
1
Exertional Heat Stroke at the Boston Marathon: Demographics and the Environment. 61
33756522 2021
2
The Role of Skeletal Muscles in Exertional Heat Stroke Pathophysiology. 61
33772503 2021
3
Immunosuppression is associated with epigenetic remodelling in a murine model of exertional heat stroke. 61
33210295 2021
4
High Schools Struggle to Adopt Evidence Based Practices for the Management of Exertional Heat Stroke. 61
33626130 2021
5
The Potential Role of Exercise-Induced Muscle Damage in Exertional Heat Stroke. 61
33528800 2021
6
Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats. 61
33574487 2021
7
Cooling Capacity of Transpulmonary Cooling and Cold-Water Immersion After Exercise-Induced Hyperthermia. 61
33543267 2021
8
Assessing the Validity of Aural Thermometry for Measuring Internal Temperature in Patients With Exertional Heat Stroke. 61
33449102 2021
9
Safety and efficacy of cold-water immersion in the treatment of older patients with heat stroke: a case series. 61
33659066 2021
10
Acute phase response to exertional heat stroke in mice. 61
32281170 2021
11
Do exertional heat stroke and environmental heat involve epigenetic memory? 61
33098309 2021
12
Research progress of heat stroke during 1989-2019: a bibliometric analysis. 61
33472705 2021
13
The relationship between 24-hour indicators and mortality in patients with exertional heat stroke. 61
33480352 2021
14
Exertional heat stroke leads to concurrent long-term epigenetic memory, immunosuppression and altered heat shock response in female mice. 61
33037634 2021
15
Incidence of Recurrent Exertional Heat Stroke in a Warm-Weather Road Race. 61
33371206 2020
16
[Experience of treating batches of exertional heat stroke patients in military training]. 61
33541509 2020
17
Roundtable on Preseason Heat Safety in Secondary School Athletics: Prehospital Care of Patients With Exertional Heat Stroke. 61
33290540 2020
18
Age- and Sex-Based Differences in Exertional Heat Stroke Incidence in a 7-Mile Road Race. 61
33176353 2020
19
Exertional heat stroke in an amateur runner - Challenges in diagnostics and the role of unhealthy competition. 61
32684111 2020
20
Exertional Heat Stroke, Modality Cooling Rate, and Survival Outcomes: A Systematic Review. 61
33167534 2020
21
Variations in the TRPV1 gene are associated to exertional heat stroke. 61
32471784 2020
22
Exertional Heat-Stroke Management Practices and Intentions Among Secondary School Football Athletic Trainers. 61
32966554 2020
23
Perceptions of Secondary School Athletic Trainers in the Diagnosis of Exertional Heat Stroke. 61
32947610 2020
24
The Contractile Phenotype of Skeletal Muscle in TRPV1 Knockout Mice is Gender-Specific and Exercise-Dependent. 61
33036239 2020
25
Chemically Activated Cooling Vest's Effect on Cooling Rate Following Exercise-Induced Hyperthermia: A Randomized Counter-Balanced Crossover Study. 61
33066469 2020
26
Heat Acclimation Improves Heat Tolerance Test Specificity in a Criteria-dependent Manner. 61
33065595 2020
27
Regional Requirements Influence Adoption of Exertional Heat Illness Preparedness Strategies in United States High Schools. 61
32977447 2020
28
Exertional Heat Illness Preparedness Strategies: Environmental Monitoring Policies in United States High Schools. 61
32977387 2020
29
Epidemiology of Exertional Heat Illness in the Military: A Systematic Review of Observational Studies. 61
32993024 2020
30
Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture. 61
32632746 2020
31
Effects of Ibuprofen during Exertional Heat Stroke in Mice. 61
32175974 2020
32
Sex differences in long-term effects of exertional heat stroke on myocardial metabolism. 61
32598028 2020
33
Emergency Medical Service Directors' Protocols for Exertional Heat Stroke. 61
32987646 2020
34
[Heat stroke on the hottest day of the year]. 61
32779922 2020
35
Nontraumatic Exertional Fatalities in Football Players, Part 2: Excess in Conditioning Kills. 61
32913873 2020
36
Nontraumatic Exertional Fatalities in Football Players, Part 1: Epidemiology and Effectiveness of National Collegiate Athletic Association Bylaws. 61
32884961 2020
37
[Exertional heat stroke in athletes and soldiers]. 61
33030323 2020
38
Establishment and effectiveness evaluation of a scoring system for exertional heat stroke by retrospective analysis. 61
32854781 2020
39
Translating evidence-based practice to clinical practice in Tokyo 2020: how to diagnose and manage exertional heat stroke. 61
32220857 2020
40
Heroic, Lifesaving Measures Are Unnecessary When Optimal Cooling Is Provided for Exertional Heat Stroke Victims. 61
32900461 2020
41
Life-threatening and major cardiac events during long-distance races: updates from the prospective RACE PARIS registry with a systematic review and meta-analysis. 61
32718236 2020
42
Comparison of wet bulb globe temperature measured on-site vs estimated and the impact on activity modification in high school football. 61
31863179 2020
43
Wilderness Medical Society Clinical Practice Guidelines for the Management of Exercise-Associated Hyponatremia: 2019 Update. 61
32044213 2020
44
Do Alternative Cooling Methods Have Effective Cooling Rates for Hyperthermia Compared With Previously Established CWI Cooling Rates? 61
31628268 2020
45
When Should a Heat-Tolerance Test Be Scheduled After Clinical Recovery From an Exertional Heat Illness? 61
31986100 2020
46
Risk perception of heat related disorders on the workplaces: a survey among health and safety representatives from the autonomous province of Trento, Northeastern Italy. 61
32490269 2020
47
First aid cooling techniques for heat stroke and exertional hyperthermia: A systematic review and meta-analysis. 61
31981710 2020
48
Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice. 61
32026469 2020
49
The Gastrointestinal Exertional Heat Stroke Paradigm: Pathophysiology, Assessment, Severity, Aetiology and Nutritional Countermeasures. 61
32093001 2020
50
A body bag can save your life: a novel method of cold water immersion for heat stroke treatment. 61
33000014 2020

Variations for Exercise-Induced Malignant Hyperthermia

Expression for Exercise-Induced Malignant Hyperthermia

Search GEO for disease gene expression data for Exercise-Induced Malignant Hyperthermia.

Pathways for Exercise-Induced Malignant Hyperthermia

GO Terms for Exercise-Induced Malignant Hyperthermia

Sources for Exercise-Induced Malignant Hyperthermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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