MCID: EXR008
MIFTS: 22

Exercise-Induced Malignant Hyperthermia

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Exercise-Induced Malignant Hyperthermia

MalaCards integrated aliases for Exercise-Induced Malignant Hyperthermia:

Name: Exercise-Induced Malignant Hyperthermia 60
Exertional Heat Stroke 60

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 T88.3
Orphanet 60 ORPHA466650

Summaries for Exercise-Induced Malignant Hyperthermia

MalaCards based summary : Exercise-Induced Malignant Hyperthermia, also known as exertional heat stroke, is related to infantile liver failure syndrome 1 and acute liver failure. An important gene associated with Exercise-Induced Malignant Hyperthermia is RYR1 (Ryanodine Receptor 1). The drugs Dantrolene and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and testes.

Related Diseases for Exercise-Induced Malignant Hyperthermia

Diseases related to Exercise-Induced Malignant Hyperthermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 infantile liver failure syndrome 1 10.3
2 acute liver failure 10.3
3 stroke, ischemic 10.2
4 burns 10.1
5 hypophosphatemia 10.1
6 malignant hyperthermia 10.0
7 cerebral hemorrhage 9.9
8 muscle disorders 9.9
9 pulmonary edema 9.9
10 hepatic coma 9.9
11 hepatic encephalopathy 9.9
12 hyperuricemia 9.9
13 myopathy 9.9
14 encephalopathy 9.9

Graphical network of the top 20 diseases related to Exercise-Induced Malignant Hyperthermia:



Diseases related to Exercise-Induced Malignant Hyperthermia

Symptoms & Phenotypes for Exercise-Induced Malignant Hyperthermia

Drugs & Therapeutics for Exercise-Induced Malignant Hyperthermia

Drugs for Exercise-Induced Malignant Hyperthermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dantrolene Approved, Investigational Phase 3,Phase 2 7261-97-4 6914273 2952
2 Peripheral Nervous System Agents Phase 3,Phase 2
3 Neuromuscular Agents Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Assess the Efficacy and Safety of Ryanodex as Adjuvant Treatment in Subjects With EHS Completed NCT03600376 Phase 3 Ryanodex and Standard of Care
2 Efficacy and Safety of Ryanodex® (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS) Completed NCT02513095 Phase 2 Dantrolene sodium for injectable suspension
3 Exertional Heat Illness: Biomarkers for Prediction and Return to Duty Unknown status NCT01434979
4 Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat Unknown status NCT02498158
5 Efficacy of an Investigational Thermal Rehab Machine on Body Cooling in Hyperthermic Individuals Completed NCT03643835 Not Applicable

Search NIH Clinical Center for Exercise-Induced Malignant Hyperthermia

Genetic Tests for Exercise-Induced Malignant Hyperthermia

Anatomical Context for Exercise-Induced Malignant Hyperthermia

MalaCards organs/tissues related to Exercise-Induced Malignant Hyperthermia:

42
Liver, Kidney, Testes, Colon, Thyroid, Neutrophil

Publications for Exercise-Induced Malignant Hyperthermia

Articles related to Exercise-Induced Malignant Hyperthermia:

(show top 50) (show all 125)
# Title Authors Year
1
Inconsistency in the Standard of Care-Toward Evidence-Based Management of Exertional Heat Stroke. ( 30833906 )
2019
2
Exertional Heat Stroke - Golden hour is the Key to Success: A Report from Peripheral Military Hospital of Northern India. ( 30935193 )
2019
3
Exertional Heat Stroke within Secondary School Athletics. ( 30969241 )
2019
4
Successful Management of Severe Exertional Heat Stroke with Endovascular Cooling After Failure of Standard Cooling Measures. ( 31005365 )
2019
5
Acute liver failure and hepatic encephalopathy in exertional heat stroke. ( 30061127 )
2018
6
Fatal Exertional Heat Stroke and American Football Players: The Need for Regional Heat-Safety Guidelines. ( 29332471 )
2018
7
Consensus Statement- Prehospital Care of Exertional Heat Stroke. ( 29336710 )
2018
8
A Functional Return-to-Play Progression After Exertional Heat Stroke in a High School Football Player. ( 29373058 )
2018
9
Management of exertional heat stroke: a practical update for primary care physicians. ( 29472229 )
2018
10
Case Series of Exertional Heat Stroke in Runners During Early Spring: 2014 to 2016 Cincinnati Flying Pig Marathon. ( 29738320 )
2018
11
Sex-dependent responses to exertional heat stroke in mice. ( 29901435 )
2018
12
Exertional Heat Stroke, the Return to Play Decision, and the Role of Heat Tolerance Testing: A Clinician's Dilemma. ( 29994825 )
2018
13
Management of exertional heat stroke. ( 30166376 )
2018
14
Liver transplantation for non-exertional heat stroke-related acute liver failure. ( 28978590 )
2017
15
Can Temperate-Water Immersion Effectively Reduce Rectal Temperature in Exertional Heat Stroke? A Critically Appraised Topic. ( 27632869 )
2017
16
Unique cytokine and chemokine responses to exertional heat stroke in mice. ( 27909226 )
2017
17
American football and fatal exertional heat stroke: a case study of Korey Stringer. ( 28314926 )
2017
18
Clinical and Biochemical Characteristics of Exertional Heat Stroke among Paratroopers in Agra, India. ( 28457033 )
2017
19
Exertional heat stroke and the evolution of field care: A physician's perspective. ( 28680920 )
2017
20
Thermoregulatory Response to Exercise After Exertional Heat Stroke. ( 28810981 )
2017
21
Exertional Heat Stroke. ( 28902747 )
2017
22
Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke. ( 29095276 )
2017
23
Dead Heat: Treating exertional heat stroke is a race against time and temperature. ( 29227612 )
2017
24
Exertional heat stroke and acute liver failure: a late dysfunction. ( 26969359 )
2016
25
Exertional Heat Stroke in a Young Athlete Resulting in Acute Liver Failure. ( 25207473 )
2016
26
Identification of variants of the ryanodine receptor type 1 in patients with exertional heat stroke and positive response to the malignant hyperthermia in vitro contracture test. ( 26994242 )
2016
27
Exertional heat stroke in a young military trainee: is it preventable? ( 27042327 )
2016
28
Electrolyte disturbances and risk factors of acute kidney injury patients receiving dialysis in exertional heat stroke. ( 27267762 )
2016
29
Misdiagnosis of Exertional Heat Stroke and Improper Medical Treatment. ( 27612373 )
2016
30
Exertional heat stroke: about 4 cases. ( 27704519 )
2016
31
Exertional Heat Stroke and American Football: What the Team Physician Needs to Know. ( 27737279 )
2016
32
A bibliometric analysis of exertional heat stroke research in Web of Science. ( 27785365 )
2016
33
An Exertional Heat Stroke Survivor's Return to Running: An Integrated Approach on the Treatment, Recovery, and Return to Activity. ( 26458109 )
2016
34
Successful treatment of exertional heat stroke using continuous plasma diafiltration. ( 26575209 )
2016
35
Acute liver failure complicating exertional heat stroke: possible role of hypophosphatemia. ( 25574884 )
2015
36
Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia? ( 26258863 )
2015
37
Exertional Heat Stroke and Susceptibility to Malignant Hyperthermia in an Athlete: Evidence for a Link? ( 26565425 )
2015
38
Protective Effects of Salidroside on Mitochondrial Functions against Exertional Heat Stroke-Induced Organ Damage in the Rat. ( 26664452 )
2015
39
Effectiveness of cold water immersion in the treatment of exertional heat stroke at the Falmouth Road Race. ( 24983342 )
2015
40
Sepsis, septic shock, and fatal exertional heat stroke. ( 25574888 )
2015
41
On-site treatment of exertional heat stroke. ( 25632055 )
2015
42
Exertional heat stroke in navy and marine personnel: a hot topic. ( 25639577 )
2015
43
Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke. ( 25814640 )
2015
44
Cold Hemodiafiltration for Exertional Heat Stroke Resulting in Multiple Organ Failure. ( 26031296 )
2015
45
The Timing of Exertional Heat Stroke Survival Starts prior to Collapse. ( 26166048 )
2015
46
Dangers of Prehospital Cooling: A Case Report of Afterdrop in a Patient with Exertional Heat Stroke. ( 26289615 )
2015
47
High-volume plasma exchange in a patient with acute liver failure due to non-exertional heat stroke in a sauna. ( 24497379 )
2014
48
Hypothesis: exertional heat stroke-induced myopathy and genetically inherited malignant hyperthermia represent the same disorder, the human stress syndrome. ( 24948473 )
2014
49
Exertional heat stroke management strategies in United States high school football. ( 24013346 )
2014
50
National collegiate athletic association strength and conditioning coaches' knowledge and practices regarding prevention and recognition of exertional heat stroke. ( 24402452 )
2014

Variations for Exercise-Induced Malignant Hyperthermia

Expression for Exercise-Induced Malignant Hyperthermia

Search GEO for disease gene expression data for Exercise-Induced Malignant Hyperthermia.

Pathways for Exercise-Induced Malignant Hyperthermia

GO Terms for Exercise-Induced Malignant Hyperthermia

Sources for Exercise-Induced Malignant Hyperthermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....