MCID: EXC001
MIFTS: 21

Exocervical Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Exocervical Carcinoma

MalaCards integrated aliases for Exocervical Carcinoma:

Name: Exocervical Carcinoma 12 15 70
Carcinoma of the Exocervix 12
Carcinoma of Exocervix 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2892
NCIt 50 C7453
SNOMED-CT 67 372100004
ICD10 32 C53.1
UMLS 70 C1299238

Summaries for Exocervical Carcinoma

Disease Ontology : 12 A cervix carcinoma that is located in the exocervix.

MalaCards based summary : Exocervical Carcinoma, also known as carcinoma of the exocervix, is related to cervix uteri carcinoma in situ and cervical intraepithelial neoplasia. An important gene associated with Exocervical Carcinoma is HSPE1 (Heat Shock Protein Family E (Hsp10) Member 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2. Affiliated tissues include exocervix and cervix, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Exocervical Carcinoma

Diseases related to Exocervical Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cervix uteri carcinoma in situ 10.0
2 cervical intraepithelial neoplasia 10.0

Symptoms & Phenotypes for Exocervical Carcinoma

GenomeRNAi Phenotypes related to Exocervical Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CEBPA DICER1 E2F2 EEF2 HNF4A HSPE1

MGI Mouse Phenotypes related to Exocervical Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 CEBPA DICER1 E2F2 EEF2 FOS HNF4A
2 vision/eye MP:0005391 9.17 CEBPA DICER1 E2F2 FOS HNF4A PLA2G6

Drugs & Therapeutics for Exocervical Carcinoma

Search Clinical Trials , NIH Clinical Center for Exocervical Carcinoma

Genetic Tests for Exocervical Carcinoma

Anatomical Context for Exocervical Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Exocervical Carcinoma:

19
Exocervix

MalaCards organs/tissues related to Exocervical Carcinoma:

40
Cervix

Publications for Exocervical Carcinoma

Articles related to Exocervical Carcinoma:

# Title Authors PMID Year
1
Synchronous invasive squamous cell carcinoma and clear cell adenocarcinoma of the uterine cervix: a different human papillomavirus status. 61
15896829 2005
2
HSP60 and HSP10 as diagnostic and prognostic tools in the management of exocervical carcinoma. 61
14675699 2003
3
[Isolated splenic metastasis in a case of adenocarcinoma of the uterine cervix. A clinical case]. 61
1491776 1992
4
Langerhans cells in squamous exocervical carcinoma: a quantitative and ultrastructural study. 61
6515744 1984
5
Measurement of nuclear DNA in the management of cervical intraepithelial neoplasia. 61
6732289 1984

Variations for Exocervical Carcinoma

Expression for Exocervical Carcinoma

Search GEO for disease gene expression data for Exocervical Carcinoma.

Pathways for Exocervical Carcinoma

Pathways related to Exocervical Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 TXNIP TXN HNF4A CEBPA
2 10.6 TXN FOS
3 10.32 FOS E2F2

GO Terms for Exocervical Carcinoma

Cellular components related to Exocervical Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 9.13 FOS E2F2 CEBPA
2 polysomal ribosome GO:0042788 8.62 RPL8 EEF2

Biological processes related to Exocervical Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to progesterone GO:0032570 8.96 TXNIP FOS
2 female pregnancy GO:0007565 8.8 PSG4 PSG1 FOS

Molecular functions related to Exocervical Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.26 HNF4A FOS E2F2 CEBPA
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 HNF4A FOS E2F2 CEBPA

Sources for Exocervical Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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