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MCID: EXC002
MIFTS: 40

Exocrine Pancreatic Insufficiency

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Exocrine Pancreatic Insufficiency

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MalaCards integrated aliases for Exocrine Pancreatic Insufficiency:

Name: Exocrine Pancreatic Insufficiency 38 12 29 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13316
ICD10 33 K86.81
MeSH 44 D010188
NCIt 50 C84316
SNOMED-CT 68 47367009
UMLS 73 C0267963
Sources

Summaries for Exocrine Pancreatic Insufficiency

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MalaCards based summary : Exocrine Pancreatic Insufficiency is related to johanson-blizzard syndrome and pancreatic agenesis 1. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (Cytochrome C Oxidase Subunit 4I2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Gastric acid production. The drugs Pancrelipase and Nitazoxanide have been mentioned in the context of this disorder. Affiliated tissues include Pancreas, testes and pancreas, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 76 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

Sources

Related Diseases for Exocrine Pancreatic Insufficiency

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Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 johanson-blizzard syndrome 32.5 CFTR UBR1
2 pancreatic agenesis 1 31.1 CFTR PDX1 PNLIP SCT SPINK1
3 cystic fibrosis 30.7 CFTR SCT SPINK1
4 duodenal atresia 30.0 CFTR SCT
5 pancreatitis 30.0 CCK CFTR PNLIP SCT SPINK1
6 diabetes mellitus, permanent neonatal 30.0 PDX1 PTF1A
7 neonatal diabetes mellitus 29.9 PDX1 PTF1A
8 steatorrhea 29.8 CCK CFTR PNLIP SCT
9 acute pancreatitis 29.0 CCK CFTR PNLIP SCT SPINK1
10 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.8
11 shwachman-diamond syndrome 1 11.8
12 pancreatic insufficiency, combined exocrine 11.4
13 poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis 11.3
14 pancreatic agenesis 2 11.3
15 diabetes mellitus 10.6
16 celiac disease 1 10.2
17 pancreatic agenesis 10.2 PDX1 PTF1A
18 diabetes mellitus, noninsulin-dependent 10.1
19 pyle disease 10.1
20 neutropenia 10.1
21 somatostatinoma 10.1
22 ichthyosis 10.1
23 dysostosis 10.1
24 cutis laxa 10.1
25 dwarfism 10.1
26 biliary dyskinesia 10.1 CCK SCT
27 duodenogastric reflux 10.1 CCK SCT
28 pancreatic cholera 10.1 CCK SCT
29 duodenal disease 10.1 CCK SCT
30 duodenal gastrinoma 10.0 CCK SCT
31 space motion sickness 10.0 CCK SCT
32 duodenal ulcer 10.0 CCK SCT
33 alzheimer disease 10.0
34 pancreas, annular 10.0
35 netherton syndrome 10.0
36 fabry disease 10.0
37 calvarial hyperostosis 10.0
38 anorexia nervosa 10.0
39 autoimmune hepatitis 10.0
40 diabetic neuropathy 10.0
41 ectodermal dysplasia 10.0
42 hepatitis 10.0
43 liver disease 10.0
44 pancreas adenocarcinoma 10.0
45 tropical sprue 10.0
46 respiratory failure 10.0
47 pancytopenia 10.0
48 hyperostosis 10.0
49 adenocarcinoma 10.0
50 lactic acidosis 10.0

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to Exocrine Pancreatic Insufficiency
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Symptoms & Phenotypes for Exocrine Pancreatic Insufficiency

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MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 CFTR PDX1 PNLIP PTF1A SPINK1 UBR1
2 endocrine/exocrine gland MP:0005379 9.73 CCK CFTR PDX1 PTF1A SPINK1 UBR1
3 growth/size/body region MP:0005378 9.7 CFTR COX4I2 PDX1 PNLIP PTF1A SPINK1
4 homeostasis/metabolism MP:0005376 9.56 CCK CFTR COX4I2 PDX1 PNLIP PTF1A
5 no phenotypic analysis MP:0003012 9.02 CCK CFTR PDX1 PTF1A SPINK1
Sources

Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

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Drugs for Exocrine Pancreatic Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53608-75-6
2
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
3 pancreatin Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
4 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
5 Antiparasitic Agents Phase 4
6 Bifidobacterium Phase 4
7 Anti-Infective Agents Phase 4,Phase 2,Phase 3
8
Omeprazole Approved, Investigational, Vet_approved Phase 3,Phase 2 73590-58-6 4594
9
Busulfan Approved, Investigational Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1 55-98-1 2478
10
Vidarabine Approved, Investigational Phase 2, Phase 3,Phase 3 24356-66-9 32326 21704
11
Fludarabine Approved Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
12
alemtuzumab Approved, Investigational Phase 2, Phase 3,Not Applicable,Early Phase 1 216503-57-0
13
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Not Applicable 6055-19-2, 50-18-0 2907
14
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
15
Ivacaftor Approved Phase 3 873054-44-5 16220172
16 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Not Applicable
17 Proton Pump Inhibitors Phase 3,Phase 2
18 Antacids Phase 3,Phase 2
19 Anti-Ulcer Agents Phase 3,Phase 2
20 Antilymphocyte Serum Phase 2, Phase 3,Phase 3,Not Applicable
21 Alkylating Agents Phase 2, Phase 3,Phase 3
22 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3
23 Immunologic Factors Phase 2, Phase 3,Phase 3,Phase 1
24 Antimetabolites Phase 2, Phase 3,Phase 3
25 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1
26 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 3
27 Antiviral Agents Phase 2, Phase 3,Phase 3
28 Antirheumatic Agents Phase 2, Phase 3,Phase 1
29 Adjuvants, Immunologic Phase 2, Phase 3
30
Secretin Approved Phase 2,Not Applicable 108153-74-8
31 tannic acid Approved Phase 2
32
Zinc Approved, Investigational Phase 2 7440-66-6
33
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
34
Selenium Approved, Investigational, Vet_approved Phase 2 7782-49-2
35
Dalteparin Approved Phase 2 9005-49-6
36
Metoclopramide Approved, Investigational Phase 2 364-62-5 4168
37
Cefazolin Approved Phase 2 25953-19-9 656510 33255
38
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
39
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
40
Melphalan Approved Phase 2,Early Phase 1 148-82-3 4053 460612
41
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
42
leucovorin Approved Phase 2 58-05-9 6006 143
43
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
44
Mycophenolic acid Approved Phase 2,Phase 1 24280-93-1 446541
45
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
46
Choline Approved, Nutraceutical Phase 2 62-49-7 305
47
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
49 Omega 3 Fatty Acid Phase 2,Not Applicable
50 Bile Acids and Salts Phase 2

Interventional clinical trials:

(show top 50) (show all 114)
# Name Status NCT ID Phase Drugs
1 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT01327703 Phase 4 Panzytrat® 25,000;Kreon® 25,000
2 PR-018: An Open-Label, Safety Extension of Study PR-011 Completed NCT01131507 Phase 4 EUR-1008 (APT-1008)
3 A Study to Evaluate the Mode of Administration and Safety of EUR-1008 (APT-1008) in Infants 1 to 12 Months of Age Completed NCT01100606 Phase 4 EUR-1008 (APT-1008);EUR-1008 (APT-1008)
4 EASY: Extended Access to Sollpura Over Years Completed NCT02823964 Phase 4 Liprotamase
5 Creon After Pancreatic Surgery Completed NCT00535756 Phase 4 Creon;Placebo
6 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
7 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
8 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
9 Irritable Bowel Syndrome Evaluation and Treatment in Primary Care Completed NCT01641341 Phase 4 Bifidobacterium infantis;Pancrelipase;Nitazoxanide;Placebo
10 HOPE - A Study to Evaluate the Effect of a Prehabilitation Program on GI Cancer Patients Planning to Undergo Surgery Enrolling by invitation NCT03642093 Phase 4
11 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4 Creon
12 Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control Terminated NCT00744250 Phase 4 Pancrelipase
13 A Study to Assess the Effect of Creon® on Pancreatic Exocrine Insufficiency in Subjects With Diabetes Mellitus Type 2 Withdrawn NCT02009410 Phase 4 Creon;Creon 25000 matching Placebo
14 Pancreatic Enzyme Suppletion in Pancreatic Cancer Withdrawn NCT01401387 Phase 4
15 Clinical Non-Inferiority of Pancreatic Enzymes (Norzyme ® - Bergamo) Compared To Creon ® (Solvay Pharmaceutical) in Patients With Exocrine Pancreatic Insufficiency Unknown status NCT01012908 Phase 2, Phase 3
16 Safety and Efficacy Study of 2 Pancreatic Enzymes for Treatment of Exocrine Pancreatic Insufficiency in Cystic Fibrosis. Completed NCT01641393 Phase 3 EUR-1008 25,000 Units;Kreon 25,000 Units
17 Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT00981214 Phase 3 EUR-1008 (APT-1008)
18 Liprotamase Efficacy Trial in Patients With Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency Completed NCT00449878 Phase 3 Liprotamase;Placebo
19 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency Completed NCT00662675 Phase 3 Pancrease MT 10.5, or MT 21;Placebo for Pancrease MT 10.5 or MT 21
20 Study to Evaluate the Safety and Efficacy of EUR-1008 (APT-1008) Pancreatic Enzyme Product in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT00297167 Phase 3 EUR-1008 (APT-1008);Placebo;Placebo;EUR-1008 (APT-1008)
21 A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI) Completed NCT00788593 Phase 3 Placebo;EUR-1008 (APT-1008) High Dose;EUR-1008 (APT-1008) Low Dose
22 A Study of SA-001 to Treat Pancreatic Exocrine Insufficiency Completed NCT00400842 Phase 3 SA-001;SA-001;Placebo
23 Open-Label Phase III Long-Term Safety Trial of Liprotamase Completed NCT00449904 Phase 3 Liprotamase
24 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Completed NCT00408317 Phase 3 Ultrase® MT20;Placebo
25 SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis Completed NCT02734810 Phase 3 Liprotamase Powder for Oral Solution
26 Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Completed NCT00775528 Phase 3 Pancrelipase Delayed Release
27 Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency (PEI) Due to Cystic Fibrosis (CF) Completed NCT00690820 Phase 3 Pancrelipase Delayed Release;Placebo Comparator
28 Evaluation of Safety and Tolerability of Creon Micro in Children Younger Than Four Years With Pancreatic Exocrine Insufficiency Completed NCT01747330 Phase 3 Pancreatin
29 A Open-label Study to Assess the Safety of Oral Long-term Use of SA-001 in Pancreatic Exocrine Insufficiency Completed NCT00401076 Phase 3 SA-001
30 Creon 40,000 for Treatment of PEI (Pancreatic Exocrine Insufficiency) Due to Chronic Pancreatitis Completed NCT00705978 Phase 3 Pancreatin;Placebo
31 A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomy Completed NCT00414908 Phase 3 Pancrelipase delayed release capsule;Placebo Comparator
32 SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis Completed NCT02279498 Phase 3 Liprotamase;porcine (pig) PERT
33 A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Completed NCT02137382 Phase 3 Creon®;Creon N
34 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Completed NCT00513682 Phase 3 Ultrase® MT20
35 Study Investigating a Delayed-Release Pancrelipase in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Completed NCT00510484 Phase 3 Pancrelipase Delayed Release;Placebo Comparator
36 Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea Completed NCT00559364 Phase 3 Viokase® 16;Placebo;Proton pump inhibitor (PPI);Omeprazole
37 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Completed NCT00432861 Phase 3 PANCRECARB® (pancrelipase);Placebo
38 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Completed NCT00880100 Phase 3 Ultrase® MT12
39 Stem Cell Transplant for Bone Marrow Failure Syndromes Completed NCT00176878 Phase 2, Phase 3 Fludarabine monophosphate;Busulfan
40 Equivalence Study to Compare Two Strengths of Creon in China Recruiting NCT03450772 Phase 3 Creon® 25000;Creon® 10000
41 RESULT: Reliable, Emergent Solution Using Liprotamase Treatment Active, not recruiting NCT03051490 Phase 3 Liprotamase;porcine PERT
42 Stem Cell Transplant for Hemoglobinopathy Active, not recruiting NCT00176852 Phase 2, Phase 3 Busulfan, Fludarabine, ATG, TLI;Busulfan, Cyclophosphamide, ATG, GCSF;Campath, Fludarabine, Cyclophosphamide
43 Phase III ALTU-135 CP Safety Trial Terminated NCT00500084 Phase 3 Liprotamase
44 A Study to Evaluate Efficacy and Safety of Ivacaftor in Subjects With Cystic Fibrosis Aged 3 Through 5 Years Who Have a Specified CFTR Gating Mutation Terminated NCT02742519 Phase 3 ivacaftor;Placebo
45 Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs Withdrawn NCT01228643 Phase 3
46 Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Completed NCT01710644 Phase 1, Phase 2 Burlulipase;Placebo (Caramel in sterile water)
47 Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Completed NCT02415959 Phase 2 Creon IR;Creon® (DR/GR)
48 Oral TheraCLECâ„¢ - Total in Cystic Fibrosis Subjects With Exocrine Pancreatic Insufficiency Completed NCT00095732 Phase 2 Liprotamase;Placebo
49 An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) Completed NCT00559052 Phase 2 VIOKASE 16
50 A Study to Investigate How Common Pancreatic Exocrine Insufficiency (PEI) is in Patients With Type 2 Diabetes and Also to Investigate the Uptake of a Single Dose of EPANOVA® or OMACOR® in Patients With Different Degrees of PEI Completed NCT02370537 Phase 2 Epanova® (omega-3 carboxylic acids);Omacor® (omega-3-acid ethyl esters)

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Cochrane evidence based reviews: exocrine pancreatic insufficiency

Sources

Genetic Tests for Exocrine Pancreatic Insufficiency

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Genetic tests related to Exocrine Pancreatic Insufficiency:

# Genetic test Affiliating Genes
1 Exocrine Pancreatic Insufficiency 29
Sources

Anatomical Context for Exocrine Pancreatic Insufficiency

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MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

41
Testes, Pancreas, Liver, Small Intestine, Neutrophil, Bone, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
# Tissue Anatomical CompartmentCell Relevance
1 Pancreas Pancreatic Acini Acinar Cells Affected by disease, potential therapeutic candidate
Sources

Publications for Exocrine Pancreatic Insufficiency

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Articles related to Exocrine Pancreatic Insufficiency:

(show top 50) (show all 294)
# Title Authors Year
1
Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. ( 29396028 )
2018
2
Transient Exocrine Pancreatic Insufficiency: First Report of an Unrecognized Complication of Cytoreductive Surgery and HIPEC. ( 29599360 )
2018
3
Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency - Systematic Review and Meta-analysis. ( 29374614 )
2018
4
Pancreatic-like enzymes of microbial origin restore growth and normalize lipid absorption in a pig model with exocrine pancreatic insufficiency. ( 29593816 )
2018
5
Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician. ( 29405509 )
2018
6
Exocrine pancreatic insufficiency in type 1 and type 2 diabetes mellitus: do we need to treat it? A systematic review. ( 29779830 )
2018
7
Diagnosis and Management of Exocrine Pancreatic Insufficiency. ( 30027527 )
2018
8
Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences. ( 30074926 )
2018
9
Serum concentrations of lipid-soluble vitamins in dogs with exocrine pancreatic insufficiency treated with pancreatic enzymes. ( 30133868 )
2018
10
Evaluation of density gradient ultracentrifugation serum lipoprotein profiles in healthy dogs and dogs with exocrine pancreatic insufficiency. ( 30175670 )
2018
11
Randomized placebo controlled clinical trial of an enteric coated micro-pelleted formulation of a pancreatic enzyme supplement in dogs with exocrine pancreatic insufficiency. ( 30221800 )
2018
12
Clinical Characteristics and Genetic Causes of Infantile Exocrine Pancreatic Insufficiency in Chinese Patients: Study From a Tertiary Care Center. ( 30308536 )
2018
13
Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues. ( 28462863 )
2017
14
Response to "Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues". ( 28566224 )
2017
15
Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase. ( 28291656 )
2017
16
A primer on exocrine pancreatic insufficiency, fat malabsorption, and fatty acid abnormalities. ( 28727474 )
2017
17
PDX1 Gene Mutation with Permanent Neonatal Diabetes Mellitus with Annular Pancreas, Duodenal Atresia, Hypoplastic Gall Bladder and Exocrine Pancreatic Insufficiency. ( 29317564 )
2017
18
Severe infantile isolated exocrine pancreatic insufficiency caused by the complete functional loss of the SPINK1 gene. ( 28945313 )
2017
19
Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome. ( 28331068 )
2017
20
Exocrine pancreatic insufficiency is common in people living with HIV on effective antiretroviral therapy. ( 28838283 )
2017
21
The fecal microbiome of dogs with exocrine pancreatic insufficiency. ( 28223257 )
2017
22
Systematic Review of Exocrine Pancreatic Insufficiency after Gastrectomy for Cancer. ( 28315875 )
2017
23
Practical guide to exocrine pancreatic insufficiency - Breaking the myths. ( 28183317 )
2017
24
Prevalence of exocrine pancreatic insufficiency in patients with chronic pancreatitis without follow-up. PANCR-EVOL Study. ( 28935122 )
2017
25
Alzheimer's disease and other neurodegenerative diseases may be due to nutritional deficiencies secondary to unrecognized exocrine pancreatic insufficiency. ( 28478840 )
2017
26
Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a meta-analysis. ( 29212278 )
2017
27
Options for addressing exocrine pancreatic insufficiency in patients receiving enteral nutrition supplementation. ( 28727476 )
2017
28
Oxalate nephropathy presenting in exocrine pancreatic insufficiency. ( 28685941 )
2017
29
Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study. ( 29078749 )
2017
30
Common clinical features of CF (respiratory disease and exocrine pancreatic insufficiency). ( 28554722 )
2017
31
Less common etiologies of exocrine pancreatic insufficiency. ( 29093615 )
2017
32
Atrophic Exocrine Pancreatic Insufficiency Associated with Anti-PD1 Therapy. ( 27864215 )
2016
33
Challenges and Updates in the Management of Exocrine Pancreatic Insufficiency. ( 26658035 )
2016
34
Applicability of a checklist for the diagnosis and treatment of severe exocrine pancreatic insufficiency. A survey on the management of pancreatic maldigestion in Italy. ( 27309260 )
2016
35
Exocrine Pancreatic Insufficiency. ( 26834230 )
2016
36
Both Exocrine Pancreatic Insufficiency and Signs of Pancreatic Inflammation Are Prevalent in Children with Complicated Severe Acute Malnutrition: An Observational Study. ( 27178623 )
2016
37
Feline Exocrine Pancreatic Insufficiency: A Retrospective Study of 150 Cases. ( 27641602 )
2016
38
Novel ciliate lipases for enzyme replacement during exocrine pancreatic insufficiency. ( 27518039 )
2016
39
Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery. ( 27045859 )
2016
40
Oral Supplementation with a Special Additive of Retinyl Palmitate and Alpha Tocopherol Reduces Growth Retardation in Young Pancreatic Duct Ligated Pigs Used as a Model for Children Suffering from Exocrine Pancreatic Insufficiency. ( 27690005 )
2016
41
Lipomatous pseudohypertrophy of pancreas with coexisting chronic calcific pancreatitis leading to malabsorption due to exocrine pancreatic insufficiency. ( 28050116 )
2016
42
Safety and Efficacy of a Novel Microbial Lipase in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis: A Randomized Controlled Clinical Trial. ( 27297209 )
2016
43
Exocrine pancreatic insufficiency in a child with Netherton syndrome. ( 26986028 )
2016
44
Rapid maxillary expansion in a pediatric patient with exocrine pancreatic insufficiency. ( 26943081 )
2016
45
Efficacy and Safety of Pancrelipase/Pancreatin in Patients With Exocrine Pancreatic Insufficiency and a Medical History of Diabetes Mellitus. ( 26495784 )
2015
46
Exocrine pancreatic insufficiency is not a cause of abdominal complaints in patients with Fabry disease. ( 25835592 )
2015
47
Diagnosis of Exocrine Pancreatic Insufficiency. ( 26077487 )
2015
48
Romanian Guidelines on the diagnosis and treatment of exocrine pancreatic insufficiency. ( 25822444 )
2015
49
Exocrine Pancreatic Insufficiency after Roux-en-Y gastric bypass. ( 26965152 )
2015
50
Exocrine pancreatic insufficiency, MRI of the pancreas and serum nutritional markers in patients with coeliac disease. ( 26253920 )
2015
Sources

Variations for Exocrine Pancreatic Insufficiency

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Expression for Exocrine Pancreatic Insufficiency

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Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.
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Pathways for Exocrine Pancreatic Insufficiency

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Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.26 CFTR PDX1 PTF1A
2
Gastric acid production 1
9.47 CCK SCT
Sources

GO Terms for Exocrine Pancreatic Insufficiency

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Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 generation of precursor metabolites and energy GO:0006091 9.32 COX4I2 PDX1
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.26 CFTR PDX1
3 pancreas development GO:0031016 9.16 PDX1 PTF1A
4 sperm capacitation GO:0048240 8.96 CFTR SPINK1
5 exocrine pancreas development GO:0031017 8.62 PDX1 PTF1A
Sources

Sources for Exocrine Pancreatic Insufficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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