MCID: EXC002
MIFTS: 43

Exocrine Pancreatic Insufficiency

Categories: Endocrine diseases

Aliases & Classifications for Exocrine Pancreatic Insufficiency

MalaCards integrated aliases for Exocrine Pancreatic Insufficiency:

Name: Exocrine Pancreatic Insufficiency 38 12 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13316
MeSH 44 D010188
NCIt 50 C84316
SNOMED-CT 68 47367009
UMLS 73 C0267963

Summaries for Exocrine Pancreatic Insufficiency

MalaCards based summary : Exocrine Pancreatic Insufficiency is related to johanson-blizzard syndrome and pancreatic agenesis 1. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (Cytochrome C Oxidase Subunit 4I2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Pancreatic secretion. The drugs Pancrelipase and Nitazoxanide have been mentioned in the context of this disorder. Affiliated tissues include Pancreas, testes and pancreas, and related phenotypes are behavior/neurological and digestive/alimentary

Wikipedia : 76 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

Related Diseases for Exocrine Pancreatic Insufficiency

Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 johanson-blizzard syndrome 32.6 CFTR UBR1
2 pancreatic agenesis 1 30.6 CFTR PDX1 PNLIP SCT
3 duodenal atresia 30.1 CFTR SCT
4 diabetes mellitus, permanent neonatal 30.0 PDX1 PTF1A
5 neonatal diabetes mellitus 29.8 PDX1 PTF1A
6 cystic fibrosis 29.4 CFTR PNLIP SCT
7 pancreatitis 29.2 CCK CFTR PNLIP SCT UBR1
8 steatorrhea 28.4 CCK CFTR PNLIP SCT
9 acute pancreatitis 27.7 CCK CCKAR PNLIP SCT
10 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.6
11 shwachman-diamond syndrome 1 11.7
12 pancreatic insufficiency, combined exocrine 11.2
13 pancreatic agenesis 2 11.1
14 diabetes mellitus 10.5
15 pancreatic agenesis 10.4 PDX1 PTF1A
16 biliary dyskinesia 10.3 CCK SCT
17 duodenal disease 10.3 CCK SCT
18 duodenogastric reflux 10.2 CCK SCT
19 pancreatic cholera 10.2 CCK SCT
20 duodenitis 10.2
21 duodenal gastrinoma 10.2 CCK SCT
22 recurrent acute pancreatitis 10.2 CFTR SCT
23 pancreas disease 10.2 CCK SCT
24 celiac disease 1 10.0
25 pyle disease 10.0
26 aging 10.0
27 neutropenia 10.0
28 somatostatinoma 10.0
29 ichthyosis 10.0
30 dysostosis 10.0
31 cutis laxa 10.0
32 dwarfism 10.0
33 opioid abuse 10.0 CCK CCKAR
34 duodenal ulcer 10.0 CCK SCT
35 opioid addiction 9.9 CCK CCKAR
36 dyspepsia 9.9 CCK CCKAR
37 alzheimer disease 9.9
38 pancreas, annular 9.9
39 netherton syndrome 9.9
40 fabry disease 9.9
41 calvarial hyperostosis 9.9
42 anorexia nervosa 9.9
43 autoimmune hepatitis 9.9
44 diabetic neuropathy 9.9
45 ectodermal dysplasia 9.9
46 hepatitis 9.9
47 liver disease 9.9
48 pancreas adenocarcinoma 9.9
49 tropical sprue 9.9
50 respiratory failure 9.9

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to Exocrine Pancreatic Insufficiency

Symptoms & Phenotypes for Exocrine Pancreatic Insufficiency

MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 UBR1 CCK CCKAR CFTR COX4I2 EFL1
2 digestive/alimentary MP:0005381 9.8 CCKAR CFTR PDX1 PNLIP PTF1A UBR1
3 endocrine/exocrine gland MP:0005379 9.73 CCK CCKAR CFTR PDX1 PTF1A UBR1
4 growth/size/body region MP:0005378 9.7 CCKAR CFTR COX4I2 PDX1 PNLIP PTF1A
5 homeostasis/metabolism MP:0005376 9.56 CCK CCKAR CFTR COX4I2 PDX1 PNLIP
6 liver/biliary system MP:0005370 9.02 CCKAR CFTR PDX1 PNLIP PTF1A

Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

Drugs for Exocrine Pancreatic Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53608-75-6
2
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
3 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
4 pancreatin Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 2,Phase 3
6 Antiparasitic Agents Phase 4
7 Bifidobacterium Nutraceutical Phase 4
8
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
9
Busulfan Approved, Investigational Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1 55-98-1 2478
10
Fludarabine Approved Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
11
Vidarabine Approved, Investigational Phase 2, Phase 3,Phase 3 24356-66-9 32326 21704
12
alemtuzumab Approved, Investigational Phase 2, Phase 3,Not Applicable,Early Phase 1 216503-57-0
13
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Not Applicable 50-18-0, 6055-19-2 2907
14
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
15 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2,Not Applicable
16 Antacids Phase 3
17 Anti-Ulcer Agents Phase 3
18 Proton Pump Inhibitors Phase 3
19 Alkylating Agents Phase 2, Phase 3,Phase 3
20 Antilymphocyte Serum Phase 2, Phase 3,Phase 3,Not Applicable
21 Antimetabolites Phase 2, Phase 3,Phase 3
22 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3
23 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 3
24 Antiviral Agents Phase 2, Phase 3,Phase 3
25 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1
26 Antirheumatic Agents Phase 2, Phase 3,Phase 1
27 Adjuvants, Immunologic Phase 2, Phase 3
28
Secretin Approved, Investigational Phase 2,Not Applicable 108153-74-8
29
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
30
Selenium Approved, Investigational, Vet_approved Phase 2 7782-49-2
31
Zinc Approved, Investigational Phase 2 7440-66-6 23994
32
Cefazolin Approved Phase 2 25953-19-9 656510 33255
33
Dalteparin Approved Phase 2 9005-49-6
34
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
35
Metoclopramide Approved, Investigational Phase 2 364-62-5 4168
36
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
37
Melphalan Approved Phase 2,Early Phase 1 148-82-3 4053 460612
38
Mycophenolate mofetil Approved, Investigational Phase 2,Phase 1 128794-94-5 5281078
39
Mycophenolic acid Approved Phase 2,Phase 1 24280-93-1 446541
40
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
41
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
42
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
43
Choline Approved, Nutraceutical Phase 2 62-49-7 305
44 tannic acid Approved, Nutraceutical Phase 2
45
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
47
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
48 Bile Acids and Salts Phase 2
49 Hypolipidemic Agents Phase 2
50 Lipid Regulating Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT01327703 Phase 4 Panzytrat® 25,000;Kreon® 25,000
2 PR-018: An Open-Label, Safety Extension of Study PR-011 Completed NCT01131507 Phase 4 EUR-1008 (APT-1008)
3 A Study to Evaluate the Mode of Administration and Safety of EUR-1008 (APT-1008) in Infants 1 to 12 Months of Age Completed NCT01100606 Phase 4 EUR-1008 (APT-1008);EUR-1008 (APT-1008)
4 EASY: Extended Access to Sollpura Over Years Completed NCT02823964 Phase 4 Liprotamase
5 Creon After Pancreatic Surgery Completed NCT00535756 Phase 4 Creon;Placebo
6 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
7 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
8 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
9 Irritable Bowel Syndrome Evaluation and Treatment in Primary Care Completed NCT01641341 Phase 4 Bifidobacterium infantis;Pancrelipase;Nitazoxanide;Placebo
10 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4 Creon
11 Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control Terminated NCT00744250 Phase 4 Pancrelipase
12 A Study to Assess the Effect of Creon® on Pancreatic Exocrine Insufficiency in Subjects With Diabetes Mellitus Type 2 Withdrawn NCT02009410 Phase 4 Creon;Creon 25000 matching Placebo
13 Pancreatic Enzyme Suppletion in Pancreatic Cancer Withdrawn NCT01401387 Phase 4
14 Clinical Non-Inferiority of Pancreatic Enzymes (Norzyme ® - Bergamo) Compared To Creon ® (Solvay Pharmaceutical) in Patients With Exocrine Pancreatic Insufficiency Unknown status NCT01012908 Phase 2, Phase 3
15 Safety and Efficacy Study of 2 Pancreatic Enzymes for Treatment of Exocrine Pancreatic Insufficiency in Cystic Fibrosis. Completed NCT01641393 Phase 3 EUR-1008 25,000 Units;Kreon 25,000 Units
16 Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT00981214 Phase 3 EUR-1008 (APT-1008)
17 Liprotamase Efficacy Trial in Patients With Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency Completed NCT00449878 Phase 3 Liprotamase;Placebo
18 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency Completed NCT00662675 Phase 3 Pancrease MT 10.5, or MT 21;Placebo for Pancrease MT 10.5 or MT 21
19 Study to Evaluate the Safety and Efficacy of EUR-1008 (APT-1008) Pancreatic Enzyme Product in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT00297167 Phase 3 EUR-1008 (APT-1008);Placebo;Placebo;EUR-1008 (APT-1008)
20 A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI) Completed NCT00788593 Phase 3 Placebo;EUR-1008 (APT-1008) High Dose;EUR-1008 (APT-1008) Low Dose
21 A Study of SA-001 to Treat Pancreatic Exocrine Insufficiency Completed NCT00400842 Phase 3 SA-001;SA-001;Placebo
22 Open-Label Phase III Long-Term Safety Trial of Liprotamase Completed NCT00449904 Phase 3 Liprotamase
23 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Completed NCT00408317 Phase 3 Ultrase® MT20;Placebo
24 SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis Completed NCT02734810 Phase 3 Liprotamase Powder for Oral Solution
25 Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Completed NCT00775528 Phase 3 Pancrelipase Delayed Release
26 Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency (PEI) Due to Cystic Fibrosis (CF) Completed NCT00690820 Phase 3 Pancrelipase Delayed Release;Placebo Comparator
27 Evaluation of Safety and Tolerability of Creon Micro in Children Younger Than Four Years With Pancreatic Exocrine Insufficiency Completed NCT01747330 Phase 3 Pancreatin
28 A Open-label Study to Assess the Safety of Oral Long-term Use of SA-001 in Pancreatic Exocrine Insufficiency Completed NCT00401076 Phase 3 SA-001
29 Creon 40,000 for Treatment of PEI (Pancreatic Exocrine Insufficiency) Due to Chronic Pancreatitis Completed NCT00705978 Phase 3 Pancreatin;Placebo
30 A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomy Completed NCT00414908 Phase 3 Pancrelipase delayed release capsule;Placebo Comparator
31 SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis Completed NCT02279498 Phase 3 Liprotamase;porcine (pig) PERT
32 A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Completed NCT02137382 Phase 3 Creon®;Creon N
33 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Completed NCT00513682 Phase 3 Ultrase® MT20
34 Study Investigating a Delayed-Release Pancrelipase in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Completed NCT00510484 Phase 3 Pancrelipase Delayed Release;Placebo Comparator
35 Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea Completed NCT00559364 Phase 3 Viokase® 16;Placebo;Proton pump inhibitor (PPI);Omeprazole
36 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Completed NCT00432861 Phase 3 PANCRECARB® (pancrelipase);Placebo
37 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Completed NCT00880100 Phase 3 Ultrase® MT12
38 Stem Cell Transplant for Bone Marrow Failure Syndromes Completed NCT00176878 Phase 2, Phase 3 Fludarabine monophosphate;Busulfan
39 Equivalence Study to Compare Two Strengths of Creon in China Recruiting NCT03450772 Phase 3 Creon® 25000;Creon® 10000
40 RESULT: Reliable, Emergent Solution Using Liprotamase Treatment Active, not recruiting NCT03051490 Phase 3 Liprotamase;porcine PERT
41 Stem Cell Transplant for Hemoglobinopathy Active, not recruiting NCT00176852 Phase 2, Phase 3 Busulfan, Fludarabine, ATG, TLI;Busulfan, Cyclophosphamide, ATG, GCSF;Campath, Fludarabine, Cyclophosphamide
42 Phase III ALTU-135 CP Safety Trial Terminated NCT00500084 Phase 3 Liprotamase
43 Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs Withdrawn NCT01228643 Phase 3
44 Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis Completed NCT01710644 Phase 1, Phase 2 Burlulipase;Placebo (Caramel in sterile water)
45 Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Completed NCT02415959 Phase 2 Creon IR;Creon® (DR/GR)
46 Oral TheraCLEC™ - Total in Cystic Fibrosis Subjects With Exocrine Pancreatic Insufficiency Completed NCT00095732 Phase 2 Liprotamase;Placebo
47 An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) Completed NCT00559052 Phase 2 VIOKASE 16
48 A Study to Investigate How Common Pancreatic Exocrine Insufficiency (PEI) is in Patients With Type 2 Diabetes and Also to Investigate the Uptake of a Single Dose of EPANOVA® or OMACOR® in Patients With Different Degrees of PEI Completed NCT02370537 Phase 2 Epanova® (omega-3 carboxylic acids);Omacor® (omega-3-acid ethyl esters)
49 Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency Completed NCT00743483 Phase 2 rhBSSL
50 Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PI Completed NCT00406536 Phase 2

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Cochrane evidence based reviews: exocrine pancreatic insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

Genetic tests related to Exocrine Pancreatic Insufficiency:

# Genetic test Affiliating Genes
1 Exocrine Pancreatic Insufficiency 29

Anatomical Context for Exocrine Pancreatic Insufficiency

MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

41
Testes, Pancreas, Bone, Liver, Bone Marrow, Small Intestine, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
# Tissue Anatomical CompartmentCell Relevance
1 Pancreas Pancreatic Acini Acinar Cells Potential therapeutic candidate, affected by disease

Publications for Exocrine Pancreatic Insufficiency

Articles related to Exocrine Pancreatic Insufficiency:

(show top 50) (show all 282)
# Title Authors Year
1
Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. ( 29396028 )
2018
2
Transient Exocrine Pancreatic Insufficiency: First Report of an Unrecognized Complication of Cytoreductive Surgery and HIPEC. ( 29599360 )
2018
3
Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency - Systematic Review and Meta-analysis. ( 29374614 )
2018
4
Pancreatic-like enzymes of microbial origin restore growth and normalize lipid absorption in a pig model with exocrine pancreatic insufficiency. ( 29593816 )
2018
5
Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician. ( 29405509 )
2018
6
Exocrine pancreatic insufficiency in type 1 and type 2 diabetes mellitus: do we need to treat it? A systematic review. ( 29779830 )
2018
7
Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues. ( 28462863 )
2017
8
Response to "Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues". ( 28566224 )
2017
9
Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase. ( 28291656 )
2017
10
A primer on exocrine pancreatic insufficiency, fat malabsorption, and fatty acid abnormalities. ( 28727474 )
2017
11
PDX1 Gene Mutation with Permanent Neonatal Diabetes Mellitus with Annular Pancreas, Duodenal Atresia, Hypoplastic Gall Bladder and Exocrine Pancreatic Insufficiency. ( 29317564 )
2017
12
Severe infantile isolated exocrine pancreatic insufficiency caused by the complete functional loss of the SPINK1 gene. ( 28945313 )
2017
13
Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome. ( 28331068 )
2017
14
Exocrine pancreatic insufficiency is common in people living with HIV on effective antiretroviral therapy. ( 28838283 )
2017
15
The fecal microbiome of dogs with exocrine pancreatic insufficiency. ( 28223257 )
2017
16
Systematic Review of Exocrine Pancreatic Insufficiency after Gastrectomy for Cancer. ( 28315875 )
2017
17
Practical guide to exocrine pancreatic insufficiency - Breaking the myths. ( 28183317 )
2017
18
Prevalence of exocrine pancreatic insufficiency in patients with chronic pancreatitis without follow-up. PANCR-EVOL Study. ( 28935122 )
2017
19
Alzheimer's disease and other neurodegenerative diseases may be due to nutritional deficiencies secondary to unrecognized exocrine pancreatic insufficiency. ( 28478840 )
2017
20
Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a meta-analysis. ( 29212278 )
2017
21
Options for addressing exocrine pancreatic insufficiency in patients receiving enteral nutrition supplementation. ( 28727476 )
2017
22
Oxalate nephropathy presenting in exocrine pancreatic insufficiency. ( 28685941 )
2017
23
Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study. ( 29078749 )
2017
24
Less common etiologies of exocrine pancreatic insufficiency. ( 29093615 )
2017
25
Common clinical features of CF (respiratory disease and exocrine pancreatic insufficiency). ( 28554722 )
2017
26
Atrophic Exocrine Pancreatic Insufficiency Associated with Anti-PD1 Therapy. ( 27864215 )
2016
27
Challenges and Updates in the Management of Exocrine Pancreatic Insufficiency. ( 26658035 )
2016
28
Applicability of a checklist for the diagnosis and treatment of severe exocrine pancreatic insufficiency. A survey on the management of pancreatic maldigestion in Italy. ( 27309260 )
2016
29
Exocrine Pancreatic Insufficiency. ( 26834230 )
2016
30
Both Exocrine Pancreatic Insufficiency and Signs of Pancreatic Inflammation Are Prevalent in Children with Complicated Severe Acute Malnutrition: An Observational Study. ( 27178623 )
2016
31
Feline Exocrine Pancreatic Insufficiency: A Retrospective Study of 150 Cases. ( 27641602 )
2016
32
Novel ciliate lipases for enzyme replacement during exocrine pancreatic insufficiency. ( 27518039 )
2016
33
Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery. ( 27045859 )
2016
34
Oral Supplementation with a Special Additive of Retinyl Palmitate and Alpha Tocopherol Reduces Growth Retardation in Young Pancreatic Duct Ligated Pigs Used as a Model for Children Suffering from Exocrine Pancreatic Insufficiency. ( 27690005 )
2016
35
Lipomatous pseudohypertrophy of pancreas with coexisting chronic calcific pancreatitis leading to malabsorption due to exocrine pancreatic insufficiency. ( 28050116 )
2016
36
Safety and Efficacy of a Novel Microbial Lipase in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis: A Randomized Controlled Clinical Trial. ( 27297209 )
2016
37
Exocrine pancreatic insufficiency in a child with Netherton syndrome. ( 26986028 )
2016
38
Rapid maxillary expansion in a pediatric patient with exocrine pancreatic insufficiency. ( 26943081 )
2016
39
Efficacy and Safety of Pancrelipase/Pancreatin in Patients With Exocrine Pancreatic Insufficiency and a Medical History of Diabetes Mellitus. ( 26495784 )
2015
40
Exocrine pancreatic insufficiency is not a cause of abdominal complaints in patients with Fabry disease. ( 25835592 )
2015
41
Diagnosis of Exocrine Pancreatic Insufficiency. ( 26077487 )
2015
42
Romanian Guidelines on the diagnosis and treatment of exocrine pancreatic insufficiency. ( 25822444 )
2015
43
Exocrine Pancreatic Insufficiency after Roux-en-Y gastric bypass. ( 26965152 )
2015
44
Exocrine pancreatic insufficiency, MRI of the pancreas and serum nutritional markers in patients with coeliac disease. ( 26253920 )
2015
45
Juvenile Diabetes Mellitus and Concurrent Exocrine Pancreatic Insufficiency in a Labrador Retriever: Long-Term Management. ( 26535463 )
2015
46
Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment. ( 25892991 )
2015
47
Association of DLA-DQB1 alleles with exocrine pancreatic insufficiency in Pembroke Welsh Corgis. ( 26095904 )
2015
48
Prevalence of exocrine pancreatic insufficiency in type 2 diabetes mellitus with poor glycemic control. ( 25278304 )
2014
49
Johanson-Blizzard syndrome: expanding the phenotype of exocrine pancreatic insufficiency. ( 25076350 )
2014
50
Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity? ( 24713840 )
2014

Variations for Exocrine Pancreatic Insufficiency

Expression for Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for Exocrine Pancreatic Insufficiency

Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 CFTR PDX1 PTF1A
2 11.11 CCKAR CFTR PNLIP
3 9.47 CCK SCT

GO Terms for Exocrine Pancreatic Insufficiency

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 generation of precursor metabolites and energy GO:0006091 9.26 COX4I2 PDX1
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.16 CFTR PDX1
3 pancreas development GO:0031016 8.96 PDX1 PTF1A
4 exocrine pancreas development GO:0031017 8.62 PDX1 PTF1A

Sources for Exocrine Pancreatic Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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