Exocrine Pancreatic Insufficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: EXC002 MIFTS: 43	Exocrine Pancreatic Insufficiency Categories: Endocrine diseases
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Aliases & Classifications for Exocrine Pancreatic Insufficiency

MalaCards integrated aliases for Exocrine Pancreatic Insufficiency:

Name: Exocrine Pancreatic Insufficiency ³⁸ ¹² ²⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13316

MeSH ⁴⁴ D010188

NCIt ⁵⁰ C84316

SNOMED-CT ⁶⁸ 47367009

UMLS ⁷³ C0267963

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Summaries for Exocrine Pancreatic Insufficiency

MalaCards based summary : Exocrine Pancreatic Insufficiency is related to johanson-blizzard syndrome and pancreatic agenesis 1. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (Cytochrome C Oxidase Subunit 4I2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Pancreatic secretion. The drugs Pancrelipase and Nitazoxanide have been mentioned in the context of this disorder. Affiliated tissues include Pancreas, testes and pancreas, and related phenotypes are behavior/neurological and digestive/alimentary

Wikipedia : ⁷⁶ Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

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Related Diseases for Exocrine Pancreatic Insufficiency

Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Related Disease	Score	Top Affiliating Genes
1	johanson-blizzard syndrome	32.6	CFTR UBR1
2	pancreatic agenesis 1	30.6	CFTR PDX1 PNLIP SCT
3	duodenal atresia	30.1	CFTR SCT
4	diabetes mellitus, permanent neonatal	30.0	PDX1 PTF1A
5	neonatal diabetes mellitus	29.8	PDX1 PTF1A
6	cystic fibrosis	29.4	CFTR PNLIP SCT
7	pancreatitis	29.2	CCK CFTR PNLIP SCT UBR1
8	steatorrhea	28.4	CCK CFTR PNLIP SCT
9	acute pancreatitis	27.7	CCK CCKAR PNLIP SCT
10	exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis	12.6
11	shwachman-diamond syndrome 1	11.7
12	pancreatic insufficiency, combined exocrine	11.2
13	pancreatic agenesis 2	11.1
14	diabetes mellitus	10.5
15	pancreatic agenesis	10.4	PDX1 PTF1A
16	biliary dyskinesia	10.3	CCK SCT
17	duodenal disease	10.3	CCK SCT
18	duodenogastric reflux	10.2	CCK SCT
19	pancreatic cholera	10.2	CCK SCT
20	duodenitis	10.2
21	duodenal gastrinoma	10.2	CCK SCT
22	recurrent acute pancreatitis	10.2	CFTR SCT
23	pancreas disease	10.2	CCK SCT
24	celiac disease 1	10.0
25	pyle disease	10.0
26	aging	10.0
27	neutropenia	10.0
28	somatostatinoma	10.0
29	ichthyosis	10.0
30	dysostosis	10.0
31	cutis laxa	10.0
32	dwarfism	10.0
33	opioid abuse	10.0	CCK CCKAR
34	duodenal ulcer	10.0	CCK SCT
35	opioid addiction	9.9	CCK CCKAR
36	dyspepsia	9.9	CCK CCKAR
37	alzheimer disease	9.9
38	pancreas, annular	9.9
39	netherton syndrome	9.9
40	fabry disease	9.9
41	calvarial hyperostosis	9.9
42	anorexia nervosa	9.9
43	autoimmune hepatitis	9.9
44	diabetic neuropathy	9.9
45	ectodermal dysplasia	9.9
46	hepatitis	9.9
47	liver disease	9.9
48	pancreas adenocarcinoma	9.9
49	tropical sprue	9.9
50	respiratory failure	9.9

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:

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Symptoms & Phenotypes for Exocrine Pancreatic Insufficiency

MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.91	UBR1 CCK CCKAR CFTR COX4I2 EFL1
2	digestive/alimentary	MP:0005381	9.8	CCKAR CFTR PDX1 PNLIP PTF1A UBR1
3	endocrine/exocrine gland	MP:0005379	9.73	CCK CCKAR CFTR PDX1 PTF1A UBR1
4	growth/size/body region	MP:0005378	9.7	CCKAR CFTR COX4I2 PDX1 PNLIP PTF1A
5	homeostasis/metabolism	MP:0005376	9.56	CCK CCKAR CFTR COX4I2 PDX1 PNLIP
6	liver/biliary system	MP:0005370	9.02	CCKAR CFTR PDX1 PNLIP PTF1A

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Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

Drugs for Exocrine Pancreatic Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pancrelipase

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

53608-75-6

Nitazoxanide

Approved, Investigational, Vet_approved

Phase 4

55981-09-4

41684

Gastrointestinal Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

pancreatin

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 2,Phase 3

Antiparasitic Agents

Phase 4

Bifidobacterium

Nutraceutical

Phase 4

Omeprazole

Approved, Investigational, Vet_approved

Phase 3

73590-58-6

4594

Busulfan

Approved, Investigational

Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1

55-98-1

2478

Fludarabine

Approved

Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1

21679-14-1, 75607-67-9

30751

Vidarabine

Approved, Investigational

Phase 2, Phase 3,Phase 3

24356-66-9

32326 21704

alemtuzumab

Approved, Investigational

Phase 2, Phase 3,Not Applicable,Early Phase 1

216503-57-0

Cyclophosphamide

Approved, Investigational

Phase 2, Phase 3,Not Applicable

50-18-0, 6055-19-2

2907

Lenograstim

Approved, Investigational

Phase 2, Phase 3

135968-09-1

Pharmaceutical Solutions

Phase 3,Phase 1,Phase 2,Not Applicable

Antacids

Phase 3

Anti-Ulcer Agents

Phase 3

Proton Pump Inhibitors

Phase 3

Alkylating Agents

Phase 2, Phase 3,Phase 3

Antilymphocyte Serum

Phase 2, Phase 3,Phase 3,Not Applicable

Antimetabolites

Phase 2, Phase 3,Phase 3

Antimetabolites, Antineoplastic

Phase 2, Phase 3,Phase 3

Antineoplastic Agents, Alkylating

Phase 2, Phase 3,Phase 3

Antiviral Agents

Phase 2, Phase 3,Phase 3

Immunosuppressive Agents

Phase 2, Phase 3,Phase 3,Phase 1

Antirheumatic Agents

Phase 2, Phase 3,Phase 1

Adjuvants, Immunologic

Phase 2, Phase 3

Secretin

Approved, Investigational

Phase 2,Not Applicable

108153-74-8

Benzocaine

Approved, Investigational

Phase 2

1994-09-7, 94-09-7

2337

Selenium

Approved, Investigational, Vet_approved

Phase 2

7782-49-2

Zinc

Approved, Investigational

Phase 2

7440-66-6

23994

Cefazolin

Approved

Phase 2

25953-19-9

656510 33255

Dalteparin

Approved

Phase 2

9005-49-6

Heparin

Approved, Investigational

Phase 2

9005-49-6

772 46507594

Metoclopramide

Approved, Investigational

Phase 2

364-62-5

4168

Octreotide

Approved, Investigational

Phase 2

83150-76-9

383414 6400441

Melphalan

Approved

Phase 2,Early Phase 1

148-82-3

4053 460612

Mycophenolate mofetil

Approved, Investigational

Phase 2,Phase 1

128794-94-5

5281078

Mycophenolic acid

Approved

Phase 2,Phase 1

24280-93-1

446541

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Methotrexate

Approved

Phase 2

1959-05-2, 59-05-2

126941

Tacrolimus

Approved, Investigational

Phase 2

104987-11-3

445643 439492

Choline

Approved, Nutraceutical

Phase 2

62-49-7

305

tannic acid

Approved, Nutraceutical

Phase 2

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 2

11103-57-4, 68-26-8

445354

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

leucovorin

Approved, Nutraceutical

Phase 2

58-05-9

143 6006

Bile Acids and Salts

Phase 2

Hypolipidemic Agents

Phase 2

Lipid Regulating Agents

Phase 2

Interventional clinical trials:

(show top 50) (show all 108)

#	Name	Status	NCT ID	Phase	Drugs
1	Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency	Completed	NCT01327703	Phase 4	Panzytrat® 25,000;Kreon® 25,000
2	PR-018: An Open-Label, Safety Extension of Study PR-011	Completed	NCT01131507	Phase 4	EUR-1008 (APT-1008)
3	A Study to Evaluate the Mode of Administration and Safety of EUR-1008 (APT-1008) in Infants 1 to 12 Months of Age	Completed	NCT01100606	Phase 4	EUR-1008 (APT-1008);EUR-1008 (APT-1008)
4	EASY: Extended Access to Sollpura Over Years	Completed	NCT02823964	Phase 4	Liprotamase
5	Creon After Pancreatic Surgery	Completed	NCT00535756	Phase 4	Creon;Placebo
6	Enzyme Suppletion in Exocrine Pancreatic Dysfunction	Completed	NCT01430234	Phase 4	Panzytrat 25.000 FIP-E units of Lipase
7	Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea	Completed	NCT00572975	Phase 4
8	Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis	Completed	NCT00957151	Phase 4	Creon
9	Irritable Bowel Syndrome Evaluation and Treatment in Primary Care	Completed	NCT01641341	Phase 4	Bifidobacterium infantis;Pancrelipase;Nitazoxanide;Placebo
10	Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase	Terminated	NCT01865695	Phase 4	Creon
11	Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control	Terminated	NCT00744250	Phase 4	Pancrelipase
12	A Study to Assess the Effect of Creon® on Pancreatic Exocrine Insufficiency in Subjects With Diabetes Mellitus Type 2	Withdrawn	NCT02009410	Phase 4	Creon;Creon 25000 matching Placebo
13	Pancreatic Enzyme Suppletion in Pancreatic Cancer	Withdrawn	NCT01401387	Phase 4
14	Clinical Non-Inferiority of Pancreatic Enzymes (Norzyme ® - Bergamo) Compared To Creon ® (Solvay Pharmaceutical) in Patients With Exocrine Pancreatic Insufficiency	Unknown status	NCT01012908	Phase 2, Phase 3
15	Safety and Efficacy Study of 2 Pancreatic Enzymes for Treatment of Exocrine Pancreatic Insufficiency in Cystic Fibrosis.	Completed	NCT01641393	Phase 3	EUR-1008 25,000 Units;Kreon 25,000 Units
16	Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency	Completed	NCT00981214	Phase 3	EUR-1008 (APT-1008)
17	Liprotamase Efficacy Trial in Patients With Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency	Completed	NCT00449878	Phase 3	Liprotamase;Placebo
18	A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency	Completed	NCT00662675	Phase 3	Pancrease MT 10.5, or MT 21;Placebo for Pancrease MT 10.5 or MT 21
19	Study to Evaluate the Safety and Efficacy of EUR-1008 (APT-1008) Pancreatic Enzyme Product in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency	Completed	NCT00297167	Phase 3	EUR-1008 (APT-1008);Placebo;Placebo;EUR-1008 (APT-1008)
20	A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI)	Completed	NCT00788593	Phase 3	Placebo;EUR-1008 (APT-1008) High Dose;EUR-1008 (APT-1008) Low Dose
21	A Study of SA-001 to Treat Pancreatic Exocrine Insufficiency	Completed	NCT00400842	Phase 3	SA-001;SA-001;Placebo
22	Open-Label Phase III Long-Term Safety Trial of Liprotamase	Completed	NCT00449904	Phase 3	Liprotamase
23	Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI)	Completed	NCT00408317	Phase 3	Ultrase® MT20;Placebo
24	SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis	Completed	NCT02734810	Phase 3	Liprotamase Powder for Oral Solution
25	Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis	Completed	NCT00775528	Phase 3	Pancrelipase Delayed Release
26	Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency (PEI) Due to Cystic Fibrosis (CF)	Completed	NCT00690820	Phase 3	Pancrelipase Delayed Release;Placebo Comparator
27	Evaluation of Safety and Tolerability of Creon Micro in Children Younger Than Four Years With Pancreatic Exocrine Insufficiency	Completed	NCT01747330	Phase 3	Pancreatin
28	A Open-label Study to Assess the Safety of Oral Long-term Use of SA-001 in Pancreatic Exocrine Insufficiency	Completed	NCT00401076	Phase 3	SA-001
29	Creon 40,000 for Treatment of PEI (Pancreatic Exocrine Insufficiency) Due to Chronic Pancreatitis	Completed	NCT00705978	Phase 3	Pancreatin;Placebo
30	A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomy	Completed	NCT00414908	Phase 3	Pancrelipase delayed release capsule;Placebo Comparator
31	SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis	Completed	NCT02279498	Phase 3	Liprotamase;porcine (pig) PERT
32	A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis	Completed	NCT02137382	Phase 3	Creon®;Creon N
33	Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI)	Completed	NCT00513682	Phase 3	Ultrase® MT20
34	Study Investigating a Delayed-Release Pancrelipase in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis	Completed	NCT00510484	Phase 3	Pancrelipase Delayed Release;Placebo Comparator
35	Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea	Completed	NCT00559364	Phase 3	Viokase® 16;Placebo;Proton pump inhibitor (PPI);Omeprazole
36	Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis	Completed	NCT00432861	Phase 3	PANCRECARB® (pancrelipase);Placebo
37	Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF)	Completed	NCT00880100	Phase 3	Ultrase® MT12
38	Stem Cell Transplant for Bone Marrow Failure Syndromes	Completed	NCT00176878	Phase 2, Phase 3	Fludarabine monophosphate;Busulfan
39	Equivalence Study to Compare Two Strengths of Creon in China	Recruiting	NCT03450772	Phase 3	Creon® 25000;Creon® 10000
40	RESULT: Reliable, Emergent Solution Using Liprotamase Treatment	Active, not recruiting	NCT03051490	Phase 3	Liprotamase;porcine PERT
41	Stem Cell Transplant for Hemoglobinopathy	Active, not recruiting	NCT00176852	Phase 2, Phase 3	Busulfan, Fludarabine, ATG, TLI;Busulfan, Cyclophosphamide, ATG, GCSF;Campath, Fludarabine, Cyclophosphamide
42	Phase III ALTU-135 CP Safety Trial	Terminated	NCT00500084	Phase 3	Liprotamase
43	Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs	Withdrawn	NCT01228643	Phase 3
44	Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis	Completed	NCT01710644	Phase 1, Phase 2	Burlulipase;Placebo (Caramel in sterile water)
45	Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis	Completed	NCT02415959	Phase 2	Creon IR;Creon® (DR/GR)
46	Oral TheraCLEC™ - Total in Cystic Fibrosis Subjects With Exocrine Pancreatic Insufficiency	Completed	NCT00095732	Phase 2	Liprotamase;Placebo
47	An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)	Completed	NCT00559052	Phase 2	VIOKASE 16
48	A Study to Investigate How Common Pancreatic Exocrine Insufficiency (PEI) is in Patients With Type 2 Diabetes and Also to Investigate the Uptake of a Single Dose of EPANOVA® or OMACOR® in Patients With Different Degrees of PEI	Completed	NCT02370537	Phase 2	Epanova® (omega-3 carboxylic acids);Omacor® (omega-3-acid ethyl esters)
49	Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency	Completed	NCT00743483	Phase 2	rhBSSL
50	Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PI	Completed	NCT00406536	Phase 2

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Cochrane evidence based reviews: exocrine pancreatic insufficiency

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Genetic Tests for Exocrine Pancreatic Insufficiency

Genetic tests related to Exocrine Pancreatic Insufficiency:

#	Genetic test	Affiliating Genes
1	Exocrine Pancreatic Insufficiency ²⁹

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Anatomical Context for Exocrine Pancreatic Insufficiency

MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

⁴¹

Testes, Pancreas, Bone, Liver, Bone Marrow, Small Intestine, Neutrophil

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:

#	Tissue Anatomical CompartmentCell	Relevance
1	Pancreas Pancreatic Acini Acinar Cells	Potential therapeutic candidate, affected by disease

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Publications for Exocrine Pancreatic Insufficiency

Articles related to Exocrine Pancreatic Insufficiency:

(show top 50) (show all 282)

#	Title	Authors	Year
1	Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. ( 29396028 )	Dimitrov B....Thiel C.	2018
2	Transient Exocrine Pancreatic Insufficiency: First Report of an Unrecognized Complication of Cytoreductive Surgery and HIPEC. ( 29599360 )	Naffouje S.A....Salti G.I.	2018
3	Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency - Systematic Review and Meta-analysis. ( 29374614 )	Vanga R.R....Othman M.	2018
4	Pancreatic-like enzymes of microbial origin restore growth and normalize lipid absorption in a pig model with exocrine pancreatic insufficiency. ( 29593816 )	Pierzynowska K....Pierzynowski S.	2018
5	Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician. ( 29405509 )	Othman M.O....Barkin J.A.	2018
6	Exocrine pancreatic insufficiency in type 1 and type 2 diabetes mellitus: do we need to treat it? A systematic review. ( 29779830 )	ZsA^ri G....CzakA^ L.	2018
7	Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues. ( 28462863 )	Safiri S....Ayubi E.	2017
8	Response to &quot;Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues&quot;. ( 28566224 )	de-Madaria E....Zapater P.	2017
9	Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase. ( 28291656 )	GonzA!lez-SA!nchez V....de-Madaria E.	2017
10	A primer on exocrine pancreatic insufficiency, fat malabsorption, and fatty acid abnormalities. ( 28727474 )	Alkaade S....Vareedayah A.A.	2017
11	PDX1 Gene Mutation with Permanent Neonatal Diabetes Mellitus with Annular Pancreas, Duodenal Atresia, Hypoplastic Gall Bladder and Exocrine Pancreatic Insufficiency. ( 29317564 )	Kulkarni A....Nabi F.	2017
12	Severe infantile isolated exocrine pancreatic insufficiency caused by the complete functional loss of the SPINK1 gene. ( 28945313 )	Venet T....FAcrec C.	2017
13	Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome. ( 28331068 )	Stepensky P....Elpeleg O.	2017
14	Exocrine pancreatic insufficiency is common in people living with HIV on effective antiretroviral therapy. ( 28838283 )	Yilmaz A....Hagberg L.	2017
15	The fecal microbiome of dogs with exocrine pancreatic insufficiency. ( 28223257 )	Isaiah A....Suchodolski J.S.	2017
16	Systematic Review of Exocrine Pancreatic Insufficiency after Gastrectomy for Cancer. ( 28315875 )	Straatman J....van der Peet D.L.	2017
17	Practical guide to exocrine pancreatic insufficiency - Breaking the myths. ( 28183317 )	Struyvenberg M.R....Freedman S.D.	2017
18	Prevalence of exocrine pancreatic insufficiency in patients with chronic pancreatitis without follow-up. PANCR-EVOL Study. ( 28935122 )	Marra-Lopez Valenciano C....de-Madaria E.	2017
19	Alzheimer's disease and other neurodegenerative diseases may be due to nutritional deficiencies secondary to unrecognized exocrine pancreatic insufficiency. ( 28478840 )	Brenner S.R.	2017
20	Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a meta-analysis. ( 29212278 )	Gan C....Liu R.	2017
21	Options for addressing exocrine pancreatic insufficiency in patients receiving enteral nutrition supplementation. ( 28727476 )	Freedman S.D.	2017
22	Oxalate nephropathy presenting in exocrine pancreatic insufficiency. ( 28685941 )	Ye J....Walker R.	2017
23	Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study. ( 29078749 )	Tu J....Li J.	2017
24	Less common etiologies of exocrine pancreatic insufficiency. ( 29093615 )	Singh V.K....Quintana Diez P.M.	2017
25	Common clinical features of CF (respiratory disease and exocrine pancreatic insufficiency). ( 28554722 )	Somayaji R....Goss C.H.	2017
26	Atrophic Exocrine Pancreatic Insufficiency Associated with Anti-PD1 Therapy. ( 27864215 )	Long G....Sandanayake N.	2016
27	Challenges and Updates in the Management of Exocrine Pancreatic Insufficiency. ( 26658035 )	Hart P.A....Conwell D.L.	2016
28	Applicability of a checklist for the diagnosis and treatment of severe exocrine pancreatic insufficiency. A survey on the management of pancreatic maldigestion in Italy. ( 27309260 )	Pezzilli R.	2016
29	Exocrine Pancreatic Insufficiency. ( 26834230 )	Bitton S....Pettei M.J.	2016
30	Both Exocrine Pancreatic Insufficiency and Signs of Pancreatic Inflammation Are Prevalent in Children with Complicated Severe Acute Malnutrition: An Observational Study. ( 27178623 )	Bartels R.H....Voskuijl W.P.	2016
31	Feline Exocrine Pancreatic Insufficiency: A Retrospective Study of 150 Cases. ( 27641602 )	Xenoulis P.G....Steiner J.M.	2016
32	Novel ciliate lipases for enzyme replacement during exocrine pancreatic insufficiency. ( 27518039 )	Brock A....Schnekenburger J.	2016
33	Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery. ( 27045859 )	Sabater L....de-Madaria E.	2016
34	Oral Supplementation with a Special Additive of Retinyl Palmitate and Alpha Tocopherol Reduces Growth Retardation in Young Pancreatic Duct Ligated Pigs Used as a Model for Children Suffering from Exocrine Pancreatic Insufficiency. ( 27690005 )	MAPA9eler A....Kamphues J.	2016
35	Lipomatous pseudohypertrophy of pancreas with coexisting chronic calcific pancreatitis leading to malabsorption due to exocrine pancreatic insufficiency. ( 28050116 )	Nema D....Mishra A.	2016
36	Safety and Efficacy of a Novel Microbial Lipase in Patients with Exocrine Pancreatic Insufficiency due to Cystic Fibrosis: A Randomized Controlled Clinical Trial. ( 27297209 )	Heubi J.E....Forssmann K.	2016
37	Exocrine pancreatic insufficiency in a child with Netherton syndrome. ( 26986028 )	Machet P....Maruani A.	2016
38	Rapid maxillary expansion in a pediatric patient with exocrine pancreatic insufficiency. ( 26943081 )	Martins-JA_nior P.A....Marques L.S.	2016
39	Efficacy and Safety of Pancrelipase/Pancreatin in Patients With Exocrine Pancreatic Insufficiency and a Medical History of Diabetes Mellitus. ( 26495784 )	Whitcomb D.C....Khurmi R.P.	2015
40	Exocrine pancreatic insufficiency is not a cause of abdominal complaints in patients with Fabry disease. ( 25835592 )	Vujasinovic M....Korat V.	2015
41	Diagnosis of Exocrine Pancreatic Insufficiency. ( 26077487 )	Hart P.A....Conwell D.L.	2015
42	Romanian Guidelines on the diagnosis and treatment of exocrine pancreatic insufficiency. ( 25822444 )	Gheorghe C....Diculescu M.	2015
43	Exocrine Pancreatic Insufficiency after Roux-en-Y gastric bypass. ( 26965152 )	BorbAcly Y....Nett P.C.	2015
44	Exocrine pancreatic insufficiency, MRI of the pancreas and serum nutritional markers in patients with coeliac disease. ( 26253920 )	Vujasinovic M....Rudolf S.	2015
45	Juvenile Diabetes Mellitus and Concurrent Exocrine Pancreatic Insufficiency in a Labrador Retriever: Long-Term Management. ( 26535463 )	Alvarez M.S....MartA-nez J.	2015
46	Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment. ( 25892991 )	Piciucchi M....Delle Fave G.	2015
47	Association of DLA-DQB1 alleles with exocrine pancreatic insufficiency in Pembroke Welsh Corgis. ( 26095904 )	Evans J.M....Clark L.A.	2015
48	Prevalence of exocrine pancreatic insufficiency in type 2 diabetes mellitus with poor glycemic control. ( 25278304 )	Terzin V....CzakA^ L.	2014
49	Johanson-Blizzard syndrome: expanding the phenotype of exocrine pancreatic insufficiency. ( 25076350 )	Ellery K.M....Erdman S.H.	2014
50	Exocrine pancreatic insufficiency and chronic pancreatitis in chronic alcoholic liver disease: coincidence or shared toxicity? ( 24713840 )	Aoufi Rabih S....TenA-as Burillo J.M.	2014

Sources

Genes for Exocrine Pancreatic Insufficiency

Genes related to Exocrine Pancreatic Insufficiency (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	COX4I2	Cytochrome C Oxidase Subunit 4I2	Protein Coding	42.96	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
2	SCT	Secretin	Protein Coding	33.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1636270 1704633 17016144
3	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	31	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
4	CCK	Cholecystokinin	Protein Coding	30.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1636270 7871858 10192202 (more) 8981511 15017660 8607504 17302791 12604981
5	PNLIP	Pancreatic Lipase	Protein Coding	26.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	11458612 8194711 18817766
6	UBR1	Ubiquitin Protein Ligase E3 Component N-Recognin 1	Protein Coding	25.97	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
7	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	Protein Coding	23.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	18493878 12677168 15645646 (more) 19126627
8	PTF1A	Pancreas Associated Transcription Factor 1a	Protein Coding	23.15	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
9	EFL1	Elongation Factor Like GTPase 1	Protein Coding	21.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	CCKAR	Cholecystokinin A Receptor	Protein Coding	21.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Exocrine Pancreatic Insufficiency

Sources

Expression for Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Sources

Pathways for Exocrine Pancreatic Insufficiency

Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.46	CFTR PDX1 PTF1A
2	Pancreatic secretion ³⁷	11.11	CCKAR CFTR PNLIP
3	Gastric acid production ¹	9.47	CCK SCT

Sources

GO Terms for Exocrine Pancreatic Insufficiency

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	generation of precursor metabolites and energy	GO:0006091	9.26	COX4I2 PDX1
2	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0035774	9.16	CFTR PDX1
3	pancreas development	GO:0031016	8.96	PDX1 PTF1A
4	exocrine pancreas development	GO:0031017	8.62	PDX1 PTF1A

Sources

Sources for Exocrine Pancreatic Insufficiency

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia