MCID: EXG001
MIFTS: 18

Exogenous Ochronosis

Categories: Rare diseases

Aliases & Classifications for Exogenous Ochronosis

MalaCards integrated aliases for Exogenous Ochronosis:

Name: Exogenous Ochronosis 54
Alkaptonuric Ochronosis 74
Ochronosis, Acquired 54

Classifications:



External Ids:

UMLS 74 C1444199

Summaries for Exogenous Ochronosis

NIH Rare Diseases : 54 Exogenous ochronosis (EO) refers to the bluish-black discoloration of areas of the skin, especially the face, ear cartilage, the ocular (eye) tissue, and other body locations.  It occurs as the result of exposure to malarial drugs, skin lightening creams and over-exposure the the sun.  Other than the skin discoloration, there are no other health effects. EO does not typically appear until adulthood and may be difficult to diagnose.  There is no specific treatment for this condition. Treatment options exist, and include prescription skin creams, vitamins, laser treatments and other skin treatments.  Exogenous ochronosis is different from hereditary ochronosis, which is an inherited condition that occurs with alkaptonuria.

MalaCards based summary : Exogenous Ochronosis, also known as alkaptonuric ochronosis, is related to ochronosis and dermatitis. The drugs Nitisinone and Tyrosine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and spinal cord.

Related Diseases for Exogenous Ochronosis

Diseases related to Exogenous Ochronosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ochronosis 12.0
2 dermatitis 10.0
3 contact dermatitis 10.0
4 allergic contact dermatitis 10.0

Symptoms & Phenotypes for Exogenous Ochronosis

Drugs & Therapeutics for Exogenous Ochronosis

Drugs for Exogenous Ochronosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitisinone Approved, Investigational Phase 2, Phase 3,Phase 3 104206-65-7 115355
2
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nitisinone (NTBC) In Different Age Groups Of Patients With Alkaptonuria Unknown status NCT01390077 Phase 2, Phase 3 Nitisinone
2 Suitability of Nitisinone in Alkaptonuria 2 Active, not recruiting NCT01916382 Phase 3 Nitisinone
3 Long-Term Study of Nitisinone to Treat Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
4 Dose Response Study of Nitisinone in Alkaptonuria Completed NCT01828463 Phase 2 Nitisinone
5 Study of Alkaptonuria Recruiting NCT00005909

Search NIH Clinical Center for Exogenous Ochronosis

Genetic Tests for Exogenous Ochronosis

Anatomical Context for Exogenous Ochronosis

MalaCards organs/tissues related to Exogenous Ochronosis:

42
Skin, Eye, Spinal Cord

Publications for Exogenous Ochronosis

Articles related to Exogenous Ochronosis:

(show top 50) (show all 90)
# Title Authors Year
1
Exogenous ochronosis: the failure of depigmenting creams. ( 31046915 )
2019
2
Dermpath & Clinic: Exogenous ochronosis. ( 31106765 )
2019
3
Dermoscopic and laser confocal features of an exogenous ochronosis case. ( 29963804 )
2018
4
A case of exogenous ochronosis associated with hydroxychloroquine. ( 30071940 )
2018
5
Alkaptonuric Ochronosis and the Failure of Regional Cerebral Tissue Oxygen Saturation Monitoring by Two Different Near-infrared Spectroscopy Devices. ( 29395825 )
2018
6
Exogenous Ochronosis in Facial Melasma. ( 28126186 )
2017
7
Image Gallery: Dermoscopy as an auxiliary tool in exogenous ochronosis. ( 28833025 )
2017
8
Alkaptonuric Ochronosis. ( 27816602 )
2017
9
Severe Aortic Valve Stenosis Due to Alkaptonuric Ochronosis. ( 28709382 )
2017
10
Alkaptonuric Ochronosis. ( 27734648 )
2016
11
Exogenous ochronosis: a comprehensive review of the diagnosis, epidemiology, causes, and treatments. ( 25837718 )
2015
12
Pigmented colloid milium associated with exogenous ochronosis in a farmer with long-term exposure to fertilizers. ( 26236412 )
2015
13
Exogenous Ochronosis. ( 26677264 )
2015
14
Coexistence of alkaptonuric ochronosis and renal cell carcinoma: an unusual association and report of a case. ( 25885152 )
2015
15
Alkaptonuric ochronosis. ( 26929770 )
2015
16
Aortic valve replacement surgery reveals previously undiagnosed alkaptonuric ochronosis. ( 24648430 )
2015
17
Exogenous ochronosis in a Chinese patient: use of dermoscopy aids early diagnosis and selection of biopsy site. ( 24452981 )
2014
18
Exogenous ochronosis. ( 24718413 )
2014
19
Treatment of exogenous ochronosis with advanced fluorescence technology. ( 25099291 )
2014
20
Reading between the layers: early histopathological findings in exogenous ochronosis. ( 25415140 )
2014
21
Exogenous ochronosis. ( 25526333 )
2014
22
Alkaptonuric ochronosis. ( 25437092 )
2014
23
Alkaptonuric ochronosis: a clinical study from Ardabil, Iran. ( 24447956 )
2014
24
Alkaptonuric ochronosis of the aorta. ( 24599900 )
2014
25
Diagnostic utility of dermatoscopy in hydroquinone-induced exogenous ochronosis. ( 22348652 )
2013
26
Effect of combination of 1064 nm Q-switched Nd:YAG and fractional carbon dioxide lasers for treating exogenous ochronosis. ( 23368689 )
2013
27
Exogenous ochronosis - successful outcome after treatment with Q-switched Nd:YAG laser. ( 23464825 )
2013
28
Exogenous ochronosis. ( 23760323 )
2013
29
Dermoscopic criteria for differentiating exogenous ochronosis from melasma. ( 24177620 )
2013
30
Exogenous ochronosis: case report and literature review. ( 22892783 )
2012
31
Exogenous ochronosis After Prolonged Use of Topical Hydroquinone (2%) in a 50-Year-Old Indian Female. ( 23112363 )
2012
32
Black aorta in a patient with alkaptonuric ochronosis. ( 22626668 )
2012
33
Exogenous ochronosis in ethnic Chinese Asians: a clinicopathological study, diagnosis and treatment. ( 21108660 )
2011
34
Use of dermoscopy for diagnosis of exogenous ochronosis. ( 22068765 )
2011
35
Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis. ( 21874298 )
2011
36
Cutaneous annular sarcoidosis developing on a background of exogenous ochronosis: a report of two cases and review of the literature. ( 19663829 )
2010
37
Exogenous ochronosis in Asians. ( 20465625 )
2010
38
Dermoscopic and reflectance confocal microscopic features of exogenous ochronosis. ( 20855704 )
2010
39
Exogenous ochronosis--a diagnostic challenge. ( 21122051 )
2010
40
Exogenous ochronosis hydroquinone induced: a report of four cases. ( 21152798 )
2010
41
Image of the month. Bluish-black pigmentation of the sclera and the aortic valve in a patient with alkaptonuric ochronosis. ( 20140788 )
2010
42
Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis. ( 20601653 )
2010
43
Hydroquinone-induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy. ( 18173595 )
2008
44
Hydroquinone-induced exogenous ochronosis in Chinese--two case reports and a review. ( 18477169 )
2008
45
Exogenous ochronosis. ( 19061605 )
2008
46
Alkaptonuric ochronosis. ( 17540644 )
2007
47
Alkaptonuric ochronosis: Report of a case and brief review. ( 23105706 )
2007
48
Exogenous ochronosis. ( 16468299 )
2006
49
Pigmented coalescing papules on the dorsa of the hands: pigmented colloid milium associated with exogenous ochronosis. ( 16674796 )
2006
50
Exogenous ochronosis and striae atrophicae following the use of bleaching creams. ( 15689207 )
2005

Variations for Exogenous Ochronosis

Expression for Exogenous Ochronosis

Search GEO for disease gene expression data for Exogenous Ochronosis.

Pathways for Exogenous Ochronosis

GO Terms for Exogenous Ochronosis

Sources for Exogenous Ochronosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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