Aliases & Classifications for Exostosis

MalaCards integrated aliases for Exostosis:

Name: Exostosis 12 15
Osteophyte 12 70 32
Exostoses 44 70
Cartilaginous Exostosis 70
Swimmer's Exostosis 12
Exostosis of Orbit 70
Orbital Exostosis 12
External Exotoses 70
Bony Outgrowth 12
Osteophytes 15
Bone Spur 12

Classifications:



External Ids:

Disease Ontology 12 DOID:203
ICD9CM 34 726.91
MeSH 44 D005096
NCIt 50 C3029
SNOMED-CT 67 80400009
ICD10 32 M25.7 M27.8
UMLS 70 C0015302 C0029423 C0155275 more

Summaries for Exostosis

Disease Ontology : 12 A hyperostosis that involves formation of new bone on the surface of preexisting bone.

MalaCards based summary : Exostosis, also known as osteophyte, is related to hereditary multiple osteochondromas and hereditary multiple exostoses. An important gene associated with Exostosis is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Clonidine and Adrenergic alpha-Agonists have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are cellular and growth/size/body region

Wikipedia : 73 An exostosis, also known as bone spur, is the formation of new bone on the surface of a bone. Exostoses... more...

Related Diseases for Exostosis

Diseases related to Exostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)
# Related Disease Score Top Affiliating Genes
1 hereditary multiple osteochondromas 32.3 POMGNT2 EXT2 EXT1
2 hereditary multiple exostoses 31.4 POMGNT2 NDST1 IHH HSPG2 EXTL3 EXTL2
3 enchondromatosis, multiple, ollier type 30.9 MMP13 IHH EXT2 EXT1 COL2A1 ACAN
4 synovitis 30.1 MMP13 COL2A1 ACAN
5 synovial chondromatosis 30.1 FN1 COL2A1
6 degenerative disc disease 30.0 MMP13 GDF5 CALCA ACAN
7 multiple enchondromatosis, maffucci type 30.0 IHH EXT2 EXT1
8 bone resorption disease 30.0 SOST CALCA BGLAP
9 chondroblastic osteosarcoma 30.0 BGLAP ACAN
10 spinal stenosis 29.8 MMP13 COL2A1 CALCA ACAN
11 achondroplasia 29.8 COL2A1 BGLAP ACAN
12 metachondromatosis 29.7 IHH EXT2 EXT1 COL2A1
13 hypochondroplasia 29.7 IHH COL2A1 ACAN
14 brachydactyly 29.7 IHH GDF5 COL2A1 ACAN
15 ankylosis 29.7 SOST GDF5 BGLAP
16 spondylolisthesis 29.6 GDF5 ACAN
17 arthropathy 29.5 MMP13 COL2A1 ACAN
18 scoliosis 29.4 MMP13 HSPG2 EXT2 COL2A1 BGLAP ACAN
19 osteoarthritis 29.4 MMP13 GDF5 COL2A1 BGLAP ACAN
20 cartilage disease 29.1 MMP13 IHH GDF5 COL2A1 ACAN
21 bone disease 28.3 SOST MMP13 GDF5 EXT2 EXT1 COL2A1
22 osteochondrodysplasia 27.8 SOST MMP13 IHH HSPG2 GDF5 FN1
23 potocki-shaffer syndrome 11.2
24 exostosis, dupuytren subungual 11.2
25 trichorhinophalangeal syndrome, type ii 11.2
26 multiple exostoses with spastic tetraparesis 11.2
27 osteochondroma 11.1
28 exostoses, multiple, type i 11.1
29 heel spur 11.1
30 exostoses with anetodermia and brachydactyly, type e 11.1
31 hyperostosis 11.0
32 bicipital tenosynovitis 10.9
33 craniosynostosis exostoses nevus epibulbar dermoid 10.9
34 ear exostoses 10.9
35 polyposis, intestinal, with multiple exostoses 10.9
36 seizures, scoliosis, and macrocephaly/microcephaly syndrome 10.9
37 torus palatinus and torus mandibularis 10.9
38 exostoses of heel 10.9
39 occipital horn syndrome 10.9
40 dysplasia epiphysealis hemimelica 10.4 EXT2 EXT1
41 chondrosarcoma 10.4
42 ankylosing spondylitis 3 10.4 EXT2 EXT1
43 juxtacortical chondroma 10.4 EXT2 EXT1
44 breast pericanalicular fibroadenoma 10.4 EXTL2 EXT2
45 spondylosis 10.4
46 spondylosis, cervical 10.3
47 exostoses, multiple, type ii 10.3
48 trichorhinophalangeal syndrome, type iii 10.3 GDF5 EXT1
49 discitis 10.3 CALCA ACAN
50 brachydactyly, type a4 10.3 IHH GDF5

Comorbidity relations with Exostosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Exostosis:



Diseases related to Exostosis

Symptoms & Phenotypes for Exostosis

MGI Mouse Phenotypes related to Exostosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 BGLAP COL12A1 COL2A1 EXT1 EXTL2 EXTL3
2 growth/size/body region MP:0005378 9.97 COL12A1 COL2A1 COL4A5 EXT1 EXTL3 FN1
3 embryo MP:0005380 9.91 COL2A1 EXT1 EXT2 EXTL3 FN1 GDF5
4 limbs/digits/tail MP:0005371 9.61 COL12A1 COL2A1 EXT1 FN1 GDF5 HSPG2
5 skeleton MP:0005390 9.4 BGLAP COL12A1 COL2A1 EXT1 EXT2 FN1

Drugs & Therapeutics for Exostosis

Drugs for Exostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-90-7 2803
2 Adrenergic alpha-Agonists Phase 4
3 Adrenergic Agonists Phase 4
4 Pharmaceutical Solutions Phase 4
5 Adrenergic Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 Antihypertensive Agents Phase 4
8 Analgesics Phase 4
9 Sympatholytics Phase 4
10
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
11 Anesthetics, General
12 Anesthetics

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer: A Prospective, Randomized, Controlled Trial Completed NCT00950053 Phase 4
2 Clonidine for Tourniquet-related Pain in Children: A Pilot Study Not yet recruiting NCT04564430 Phase 4 Catapresan
3 Autologous Stem Cells in Achilles Tendinopathy Unknown status NCT02064062 Phase 2
4 A Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Palovarotene in Subjects With Multiple Osteochondromas Terminated NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
5 Distal Phalangeal Bone Involvement Observed by High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) in Patients With Nail Psoriasis Unknown status NCT02813720
6 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
7 Effect of Chosen Treatment Methods on Pain, ROM, Associated Symptoms and Functioning in Patients With Cervical Spine Osteoarthritis: Randomised Control Trial Completed NCT03683602
8 Virtual Reality Distraction From Procedural Pain in Children Completed NCT03998995
9 Comparisons of TESSYS and "U" Route Procedures of Transforaminal Percutaneous Endoscopic Lumbar Discectomy on Lumbar Spinal Stenosis Treatment Completed NCT04314453
10 Patellar Resurfacing in Total Knee Arthroplasty. A Prospective, Randomised and Double Blind Study. Completed NCT00553982
11 What is the Clinical and Cost Effectiveness of Arthroscopic Sub-acromial Decompression Surgery? Completed NCT01623011
12 Functional Follow-up After Endoscopic Calcaneoplasty for Haglund's Deformity Completed NCT04471259
13 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
14 Distraction Versus Interposition Arthroplasty for Thumb Carpometacarpal Joint Osteoarthritis: A Randomized Controlled Trial Recruiting NCT04155853
15 Results of the Treatment of Patients With Elbow Osteoarthritis Recruiting NCT02951403
16 A Randomized, Controlled Trial of Lateral Lumbar Interbody Fusion Plus Posterior Decompression or Not for Severe Lumbar Spinal Stenosis Recruiting NCT04094220
17 Örebro Multicenter Study on Operative Treatment of Cervical Radiculopathy: Anterior Cervical Decompression and Fusion Versus Posterior Foraminotomy Recruiting NCT04177849
18 Comparison of Arthroscopic Debridement and Arthroscopic Hemi-Trapeziectomy With Mini TightRope on Patients With Thumb Carpometacarpal Joint Osteoarthritis - A Prospective Randomized Single-Blinded Controlled Trial Recruiting NCT04217928
19 The Effect of Arthroscopic Subacromial Decompression in Patients With Subacromial Impingement Syndrome Who Are Non-responders to Non-operative Treatment. A Double-blinded, Randomized, Controlled Trial. Recruiting NCT04644042
20 Cervical Spondylotic Myelopathy Surgical Trial Active, not recruiting NCT02076113
21 Registry of Multiple Osteochondromas That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Quality of Life Data. Data Are Linked to Patients Biological Sample Enrolling by invitation NCT04133285
22 Treatment of Hallux Rigidus With Synthetic Hemiarthroplasty Versus Cheilectomy: A Randomized Controlled Trial Suspended NCT03935880
23 Genotype-Phenotype Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
24 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Exostosis

Cochrane evidence based reviews: exostoses

Genetic Tests for Exostosis

Anatomical Context for Exostosis

MalaCards organs/tissues related to Exostosis:

40
Bone, Spinal Cord, Bone Marrow, Breast, Thyroid, Myeloid, Endothelial

Publications for Exostosis

Articles related to Exostosis:

(show top 50) (show all 3624)
# Title Authors PMID Year
1
The molecular and cellular basis of exostosis formation in hereditary multiple exostoses. 61 54
18452536 2008
2
Cytoskeletal abnormalities in chondrocytes with EXT1 and EXT2 mutations. 54 61
10750558 2000
3
Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses. 61 54
9463333 1998
4
Spontaneous extensor tendon rupture due to scaphoid osteophyte: A case report and literature review. 61
33786359 2021
5
Adrenergic signalling in osteoarthritis. 61
33571663 2021
6
Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice. 61
33210027 2021
7
Glenoid bony morphology of osteoarthritis prior to shoulder arthroplasty: what the surgeon wants to know and why. 61
33095290 2021
8
Bow Hunter's Syndrome. 61
33476780 2021
9
Reproducible Presyncope Due to Osteophyte Compression Into Transverse Foramen of the C5 Vertebra. 61
33476963 2021
10
The Clinical Radiographic Incidence of Posttraumatic Osteoarthritis 10 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON Nested Cohort. 61
33793363 2021
11
Coccygectomy for coccygodynia: a cohort study with a long-term follow-up of up to 29 years. 61
33141347 2021
12
Nail Tumors. 61
33745640 2021
13
Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes. 61
33680110 2021
14
Development of MRI-defined Structural Tissue Damage after Anterior Cruciate Ligament Injury over 5 Years: The KANON Study. 61
33687286 2021
15
Increased 68Ga-FAPI Uptake in Chronic Cholecystitis and Degenerative Osteophyte. 61
33782317 2021
16
Dysphagia in a patient with ankylosing spondylitis: A case report. 61
33728307 2021
17
Morphological changes in the vertebral artery subsequent to cervical spine degeneration and aging: analyses by computed tomography angiography using multiplanar and three-dimensional reconstructions. 61
33771746 2021
18
Correlations between dental wear and oral cavity characteristics: Mandibular torus, palatine torus, and oral exostoses. 61
32537788 2021
19
The Incidence of Vertebral Exostoses in Multiple Hereditary Exostoses and Recommendations for Spinal Screening. 61
33417389 2021
20
Rare association of anatomical variations of the atlas and the occipital in a case with cranial deformation. 61
33044627 2021
21
Rib osteochondroma causing cardiac compression in a pediatric patient. 61
33743258 2021
22
A Surprising Cause of Contained Aortic Rupture: Perforation from a Lumbar Osteophyte. 61
33761564 2021
23
Thoracic osteophyte as a cause of symptomatic greater splanchnic nerve compression. Case report. 61
33771615 2021
24
Impact of smoking on femorotibial and hip osteoarthritis progression: 3-year follow-up data from the KHOALA cohort. 61
32950705 2021
25
MRI-defined Osteophyte Presence and Concomitant Cartilage Damage in Knees with Incident Tibiofemoral Osteoarthritis: Data From The Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses (POMA) Study. 61
33770420 2021
26
Radiographic changes in the temporomandibular joint related to medication in rheumatic diseases. 61
33684330 2021
27
FOXM1 activates JAK1/STAT3 pathway in human osteoarthritis cartilage cell inflammatory reaction. 61
33297736 2021
28
An Unrecognized Ligament and its Ossification in the Craniocervical Junction: Prevalence, Patient Characteristics, and Anatomic Evidence. 61
33739308 2021
29
Long-term Natural Course of the Osteochondral Lesion of the Talus in a Child: A Case Report. 61
33168445 2021
30
[Enhance the study on surgical indication for cervical artificial disc replacement and reduce the occurrence of heterotopic ossification]. 61
33685040 2021
31
The Rationale for the Intra-Articular Administration of Clodronate in Osteoarthritis. 61
33799992 2021
32
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration. 61
32885253 2021
33
Imaging features of synovial chondromatosis of the temporomandibular joint: a report of 34 cases. 61
33762137 2021
34
Cervical spine MRI phenotypes and prediction of pain, disability and adjacent segment degeneration/disease after ACDF. 61
32159238 2021
35
Radiographic cervical spine degenerative findings: a study on a large population from age 18 to 97 years. 61
33025192 2021
36
Impact of ear protection on occurrence of exostosis in surfers: an observational prospective study of 242 ears. 61
33555441 2021
37
Dorsal Medial Cuneiform Bony Outgrowth-Apophysis or Exostosis: A Case Report. 61
33577190 2021
38
Dupuytren Subungual Exostosis. 61
33632969 2021
39
Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients. 61
33673583 2021
40
Posterior nutcracker syndrome: a case report. 61
33522968 2021
41
Subtalar joint pigmented villonodular synovitis misdiagnosed at the first visit: A case report. 61
33644205 2021
42
Obturator nerve impingement caused by an osteophyte in the sacroiliac joint: A case report. 61
33644181 2021
43
Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. 61
33022338 2021
44
Optimization of histologic grading schemes in spontaneous and surgically-induced murine models of osteoarthritis. 61
33561541 2021
45
[Osteophyte-induced impingement reduces range of motion in humpback deformity of incorrectly healed scaphoid reconstruction]. 61
32474616 2021
46
Diagnosis, Management, and Treatment Options: A Cervical Spine Osteochondroma Meta-Analysis. 61
33561553 2021
47
The cholinergic system in joint health and osteoarthritis: a narrative-review. 61
33609692 2021
48
Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model. 61
33567513 2021
49
Feasibility of arthroscopic decompression of the axillary nerve in the quadrilateral space: Cadaver study. 61
33333278 2021
50
Bipedicle Advancement Flap for Skin Coverage after Digital Mucous Cyst Excision: A Retrospective Study of 18 Cases. 61
33283444 2021

Variations for Exostosis

ClinVar genetic disease variations for Exostosis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GLI2 NM_001374353.1(GLI2):c.2593A>T (p.Thr865Ser) SNV Uncertain significance 523482 rs1332140763 GRCh37: 2:121746134-121746134
GRCh38: 2:120988558-120988558

Expression for Exostosis

Search GEO for disease gene expression data for Exostosis.

Pathways for Exostosis

Pathways related to Exostosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 IRS4 IHH HSPG2 GDF5 FN1 COL4A5
2
Show member pathways
13.22 MMP13 HSPG2 FN1 COL4A5 COL2A1 COL12A1
3
Show member pathways
12.84 HSPG2 GDF5 FN1 COL4A5 COL2A1 COL12A1
4
Show member pathways
12.67 NDST1 HSPG2 EXT2 EXT1 ACAN
5
Show member pathways
12.41 MMP13 HSPG2 GDF5 FN1 COL4A5 COL2A1
6
Show member pathways
11.97 HSPG2 FN1 COL4A5 COL2A1
7 11.75 SOST MMP13 BGLAP
8 11.48 MMP13 IHH COL2A1 ACAN
9 11.41 MMP13 FN1 COL4A5 COL2A1
10 11.41 HSPG2 GDF5 FN1 COL2A1 BGLAP ACAN
11 11.36 MMP13 FN1 COL4A5
12 11.22 MMP13 IHH BGLAP
13 11.17 FN1 COL2A1 ACAN
14
Show member pathways
10.93 NDST1 EXTL3 EXTL2 EXTL1 EXT2 EXT1
15 10.88 FN1 COL2A1
16 10.7 HSPG2 GDF5 FN1 COL4A5 COL2A1 COL12A1

GO Terms for Exostosis

Cellular components related to Exostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 SOST MMP13 IHH HSPG2 GDF5 FN1
2 Golgi apparatus GO:0005794 9.98 SOST NDST1 EXTL3 EXTL1 EXT2 EXT1
3 endoplasmic reticulum membrane GO:0005789 9.95 POMGNT2 EXTL3 EXTL2 EXTL1 EXT2 EXT1
4 endoplasmic reticulum lumen GO:0005788 9.8 FN1 COL4A5 COL2A1 COL12A1 BGLAP
5 extracellular matrix GO:0031012 9.8 MMP13 IHH FN1 COL4A5 COL2A1 ACAN
6 collagen trimer GO:0005581 9.67 MMP13 COL4A5 COL2A1 COL12A1
7 Golgi lumen GO:0005796 9.63 HSPG2 BGLAP ACAN
8 basement membrane GO:0005604 9.55 HSPG2 FN1 COL4A5 COL2A1 ACAN
9 collagen-containing extracellular matrix GO:0062023 9.5 SOST HSPG2 FN1 COL4A5 COL2A1 COL12A1
10 extracellular region GO:0005576 9.44 SOST MMP13 IHH HSPG2 GDF5 FN1

Biological processes related to Exostosis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.04 FN1 EXT1 COL12A1 BGLAP ACAN
2 cellular protein metabolic process GO:0044267 9.91 MMP13 HSPG2 FN1 CALCA
3 extracellular matrix organization GO:0030198 9.85 MMP13 HSPG2 FN1 COL4A5 COL2A1 ACAN
4 cartilage development GO:0051216 9.8 MMP13 IHH GDF5 COL2A1
5 response to mechanical stimulus GO:0009612 9.78 SOST IHH GDF5 BGLAP
6 regulation of blood pressure GO:0008217 9.77 EXT2 EXT1 CALCA
7 IRE1-mediated unfolded protein response GO:0036498 9.75 EXTL3 EXTL2 EXTL1
8 collagen fibril organization GO:0030199 9.73 EXT1 COL2A1 COL12A1 ACAN
9 protein glycosylation GO:0006486 9.73 POMGNT2 EXTL3 EXTL2 EXTL1 EXT2 EXT1
10 endochondral ossification GO:0001958 9.7 MMP13 EXT1 COL2A1
11 vasodilation GO:0042311 9.69 EXT2 EXT1 CALCA
12 cartilage condensation GO:0001502 9.64 COL2A1 ACAN
13 sulfation GO:0051923 9.63 EXT2 EXT1
14 sodium ion homeostasis GO:0055078 9.63 EXT2 EXT1
15 heparin biosynthetic process GO:0030210 9.63 NDST1 EXT2 EXT1
16 skeletal system development GO:0001501 9.63 IHH EXTL1 EXT1 COL2A1 BGLAP ACAN
17 heart contraction GO:0060047 9.62 EXT2 EXT1
18 chondrocyte proliferation GO:0035988 9.62 IHH EXT1
19 glycosaminoglycan biosynthetic process GO:0006024 9.62 NDST1 HSPG2 EXT2 EXT1
20 multicellular organismal water homeostasis GO:0050891 9.61 EXT2 EXT1
21 proteoglycan metabolic process GO:0006029 9.59 IHH COL2A1
22 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.58 EXT1 COL2A1
23 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.58 NDST1 EXT2 EXT1
24 embryonic skeletal joint development GO:0072498 9.57 IHH EXT1
25 endochondral bone morphogenesis GO:0060350 9.56 EXT2 EXT1
26 fluid transport GO:0042044 9.55 EXT2 EXT1
27 cellular polysaccharide biosynthetic process GO:0033692 9.54 EXT2 EXT1
28 ossification GO:0001503 9.43 SOST IHH EXT2 EXT1 COL2A1 BGLAP
29 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.02 NDST1 EXTL3 EXTL2 EXT2 EXT1

Molecular functions related to Exostosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.73 FN1 COL4A5 COL2A1 ACAN
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.63 COL4A5 COL2A1 COL12A1
3 glucuronosyltransferase activity GO:0015020 9.58 EXTL1 EXT2 EXT1
4 extracellular matrix structural constituent conferring compression resistance GO:0030021 9.51 HSPG2 ACAN
5 proteoglycan binding GO:0043394 9.49 FN1 COL2A1
6 BMP binding GO:0036122 9.48 SOST GDF5
7 acetylglucosaminyltransferase activity GO:0008375 9.46 POMGNT2 EXTL1 EXT2 EXT1
8 transferase activity, transferring glycosyl groups GO:0016757 9.43 POMGNT2 EXTL3 EXTL2 EXTL1 EXT2 EXT1
9 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.37 EXT2 EXT1
10 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.32 EXT2 EXT1
11 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0001888 9.26 EXTL3 EXTL2
12 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.8 EXTL1 EXT2 EXT1

Sources for Exostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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