MCID: EXT022
MIFTS: 42

Exotropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Exotropia

MalaCards integrated aliases for Exotropia:

Name: Exotropia 12 76 29 6 15 73
Divergent Concomitant Strabismus 12
Divergent Strabismus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1143
ICD10 33 H50.1 H50.10
ICD9CM 35 378.1 378.10
MeSH 44 D005099
NCIt 50 C34601
UMLS 73 C0015310

Summaries for Exotropia

MalaCards based summary : Exotropia, also known as divergent concomitant strabismus, is related to esotropia and amblyopia. An important gene associated with Exotropia is TUBB3 (Tubulin Beta 3 Class III). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related phenotypes are cellular and respiratory system

Wikipedia : 76 Exotropia is a form of strabismus where the eyes are deviated outward. It is the opposite of esotropia... more...

Related Diseases for Exotropia

Diseases related to Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 esotropia 31.8 CHN1 ROBO3 TUBB3
2 amblyopia 30.2 CHN1 TUBB3
3 hypertropia 30.0 CHN1 KIF21A TUBB3
4 strabismus 29.8 CHN1 KIF21A PHOX2A TUBB3
5 duane retraction syndrome 29.6 CHN1 KIF21A TUBB3
6 ptosis 29.5 KIF21A PHOX2A TUBB3
7 hypotropia 29.1 CHN1 KIF21A PHOX2A TUBB3
8 alternating exotropia 12.2
9 monocular exotropia 12.0
10 mehes syndrome 11.1
11 focal facial dermal dysplasia 3, setleis type 10.9
12 lowry-maclean syndrome 10.9
13 miles-carpenter syndrome 10.9
14 mental retardation smith fineman myers type 10.9
15 marcus gunn phenomenon 10.4 CHN1 TUBB3
16 chondroid chordoma 10.4 ACAN TUBB3
17 keratopathy 10.3 FBN1 TUBB3
18 fibrosis of extraocular muscles, congenital, 2 10.3 KIF21A PHOX2A
19 enophthalmos 10.2 CHN1 TNNI3K
20 pectus excavatum 10.2 ACAN FBN1
21 aging 10.2
22 facial paralysis 10.2 TNNI3K TUBB3
23 poland syndrome 10.2 CHN1 TUBB3
24 orbital disease 10.2 CHN1 TNNI3K
25 retinitis 10.1
26 idiopathic scoliosis 10.1 ACAN FBN1
27 myopia 10.1
28 internuclear ophthalmoplegia 10.1
29 bone structure disease 10.0 ACAN FBN1 ROBO3
30 deafness, autosomal dominant 28 10.0 CHN1 KIF21A TUBB3
31 autonomic nervous system disease 9.9 PHOX2A PHOX2B
32 facial nerve disease 9.9 KIF21A PHOX2A TUBB3
33 hypertelorism 9.9
34 accommodative esotropia 9.9
35 scoliosis 9.9 ACAN FBN1 ROBO3
36 kearns-sayre syndrome 9.9 KIF21A PHOX2A TUBB3
37 keratoconus 9.8
38 thyroiditis 9.8
39 refractive error 9.8
40 supranuclear ocular palsy 9.8
41 isolated duane retraction syndrome 9.8
42 anisocoria 9.7
43 crouzon syndrome 9.7
44 multiple sclerosis 9.7
45 duane retraction syndrome 1 9.7
46 frontonasal dysplasia 1 9.7
47 attention deficit-hyperactivity disorder 9.7
48 marfan syndrome 9.7
49 medulloblastoma 9.7
50 ocular dominance 9.7

Graphical network of the top 20 diseases related to Exotropia:



Diseases related to Exotropia

Symptoms & Phenotypes for Exotropia

MGI Mouse Phenotypes related to Exotropia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 ROBO3 TNNI3K TUBB3 CHN1 FBN1 PHOX2A
2 respiratory system MP:0005388 9.02 PHOX2B ROBO3 TUBB3 FBN1 PHOX2A

Drugs & Therapeutics for Exotropia

Drugs for Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Not Applicable 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Botulinum Toxins Phase 4,Not Applicable
4 Botulinum Toxins, Type A Phase 4
5 Cholinergic Agents Phase 4,Not Applicable
6 Neuromuscular Agents Phase 4
7 Neurotransmitter Agents Phase 4,Not Applicable
8 onabotulinumtoxinA Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
10 Pharmaceutical Solutions Phase 4
11
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
14 Anesthetics Phase 2, Phase 3,Not Applicable
15 Anesthetics, Local Phase 2, Phase 3
16 Central Nervous System Depressants Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18 Autonomic Agents Not Applicable
19 Mydriatics Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
3 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
4 Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
5 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries Unknown status NCT02450162
6 A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650 Not Applicable
7 Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness Completed NCT02131792 Not Applicable
8 A Novel Diagnostic Method for Exotropia Using Video-oculography Completed NCT03119311 Not Applicable
9 Observation Versus Occlusion Therapy for Intermittent Exotropia Completed NCT01032330 Not Applicable
10 Surgery and Convergence Insufficiency Intermittent Exotropia Completed NCT01435876 Not Applicable
11 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) Completed NCT02383381
12 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580 Not Applicable
13 Assessing the Functional and Psychosocial Impact of Strabismus in Asian Children Using the AS-20 and IXTQ Questionnaires Completed NCT01608828
14 Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02902887 Not Applicable
15 Study of Surgical Treatment Versus Observation in Children With Moderate Intermittent Exotropia Recruiting NCT02736526 Not Applicable
16 Trial of Overminus Spectacle Therapy for Intermittent Exotropia Recruiting NCT02807350 Not Applicable
17 Basic Intermittent Exotropia and Risk Factors for Postoperative Overcorrection and Under Correction Recruiting NCT03153423 Not Applicable
18 Strabismus Surgery and Driving Ability Recruiting NCT02570555
19 Office Based Vergence and Accommodative Therapy and Intermittent Exotropia Active, not recruiting NCT03321838 Not Applicable
20 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603 Not Applicable
21 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836 Not Applicable
22 Botulinum Toxin Augmented Surgery vs Conventional Surgery in the Management of Large Angle Infantile Esotropia Not yet recruiting NCT03266549 Not Applicable
23 Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Terminated NCT02466659 Not Applicable

Search NIH Clinical Center for Exotropia

Genetic Tests for Exotropia

Genetic tests related to Exotropia:

# Genetic test Affiliating Genes
1 Exotropia 29

Anatomical Context for Exotropia

MalaCards organs/tissues related to Exotropia:

41
Eye, Testes, Thyroid, Cortex, Pineal, Brain

Publications for Exotropia

Articles related to Exotropia:

(show top 50) (show all 664)
# Title Authors Year
1
The difference of surgical outcomes between manifest exotropia and esotropia. ( 29922977 )
2018
2
Acute transient large-angle exotropia caused by traumatic orbital contusion. ( 29482420 )
2018
3
Infantile Exotropia and Developmental Delay. ( 29709041 )
2018
4
Effects of Surgical Assistant's Level of Resident Training on Surgical Treatment of Intermittent Exotropia: Operation Time and Surgical Outcomes. ( 29376227 )
2018
5
Comparison of the characteristics of patients with intermittent exotropia according to response to diagnostic monocular occlusion. ( 29383541 )
2018
6
Role of fusional convergence amplitude in postoperative phoria maintenance in children with intermittent exotropia. ( 29556848 )
2018
7
A quantitative analysis method for comitant exotropia using video-oculography with alternate cover. ( 29566654 )
2018
8
Clinical and Histopathologic Features of Consecutive Exotropia. ( 29494263 )
2018
9
Re: Economides etA al.: Capturing the moment of fusion loss in intermittent exotropia (Ophthalmology. 2017;124;496-504). ( 29389411 )
2018
10
Effect of combining inferior oblique muscle weakening procedures with exotropia surgery on the surgical correction of exotropia. ( 29795692 )
2018
11
Surgical Outcome of Intermittent Exotropia With Improvement in Control Grade Subsequent to Part-time Preoperative Occlusion Therapy. ( 28991346 )
2018
12
Bilateral lateral rectus recession versus unilateral recession resection for basic intermittent exotropia: a meta-analysis. ( 29368040 )
2018
13
Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study. ( 29675389 )
2018
14
Long-term Outcomes After Same Amount of Bilateral Rectus Muscle Recession for Intermittent Exotropia With the Same Angle of Deviation. ( 29913026 )
2018
15
Reduction of Consecutive Esotropia Using Modified Contralateral Recession and Resection for Recurrent Intermittent Exotropia. ( 28991342 )
2018
16
Clinical and surgical risk factors for consecutive exotropia. ( 29667435 )
2018
17
Early postoperative changes of motor alignment after surgery for intermittent exotropia. ( 29305730 )
2018
18
Long-term Surgical Outcomes of Initial Postoperative Overcorrection in Adults with Intermittent Exotropia. ( 29770641 )
2018
19
Esotropia and Exotropia Preferred Practice PatternAr. ( 29108746 )
2018
20
Analysis of alterations in white matter integrity of adult patients with comitant exotropia. ( 29569963 )
2018
21
Factors affecting surgical outcome of intermittent exotropia. ( 29675346 )
2018
22
Clinical study of the effect of refractive status on stereopsis in children with intermittent exotropia. ( 29921242 )
2018
23
The fast exodrift after the first surgical treatment of exotropia and its correlation with surgical outcome of second surgery. ( 29499664 )
2018
24
Congenital Bilateral Inferior Rectus Muscle Absence with A-type Exotropia. ( 29611375 )
2018
25
The clinical effect of surgical timing in infantile exotropia. ( 29526714 )
2018
26
Medial and Lateral Rectus Muscle Insertion Distance and Width in Esotropia and Exotropia Patients. ( 28632404 )
2017
27
Variability of preoperative measurements in intermittent exotropia and its effect on surgical outcome. ( 29289689 )
2017
28
Effect of horizontal rectus surgery for the correction of intermittent exotropia on sub-A or sub-V pattern. ( 28628645 )
2017
29
Proposing a new scoring system in intermittent exotropia: towards a better assessment of control. ( 28576201 )
2017
30
Intermittent exotropia surgery: results in different age groups. ( 29267569 )
2017
31
Far distance control scores for assessing intermittent exotropia. ( 28673866 )
2017
32
Expression of schizophrenia biomarkers in extraocular muscles from patients with strabismus: an explanation for the link between exotropia and schizophrenia? ( 29302405 )
2017
33
Capturing the Moment of Fusion Loss in Intermittent Exotropia. ( 28081943 )
2017
34
The Riddle of Intermittent Exotropia. ( 28813579 )
2017
35
Comparison of outcomes of unilateral recession-resection as primary surgery and reoperation for intermittent Exotropia. ( 28679404 )
2017
36
Early versus late surgery for infantile exotropia. ( 29158152 )
2017
37
Long-term outcomes of augmented unilateral recess-resect procedure in children with intermittent exotropia. ( 28985221 )
2017
38
Exotropia in a pediatric patient with rhabdomyolysis caused by an insect sting. ( 28643726 )
2017
39
Comparison of adjustable sutures versus nonadjustable sutures in intermittent exotropia. ( 29077181 )
2017
40
Congenital Double Elevator Palsy with Sensory Exotropia: A Unique Surgical Management. ( 28540016 )
2017
41
Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study. ( 28679330 )
2017
42
The Effect of Preoperative Occlusion Therapy on Long-term Outcome after Surgery for Early-onset Exotropia. ( 28534342 )
2017
43
Clinical Features and Surgical Outcome of Triad Exotropia. ( 28678305 )
2017
44
Surgical results for consecutive exotropia. ( 29018765 )
2017
45
Factors affecting residual exotropia after two muscle surgery for intermittent exotropia. ( 28730116 )
2017
46
Everyday Exotropia: Learning from the Littlest. ( 28904215 )
2017
47
Factors associated with atypical postoperative drift following surgery for consecutive exotropia. ( 28867397 )
2017
48
Predictors of surgical success in patients with intermittent exotropia. ( 28089744 )
2017
49
Long-Term Surgical Outcomes of Early Surgery for Intermittent Exotropia in Children Less than 4 Years of Age. ( 28910161 )
2017
50
Exotropia and hypotropia as the initial presentation sign of thyroid eye disease in an 18-year-old man. ( 29288834 )
2017

Variations for Exotropia

ClinVar genetic disease variations for Exotropia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(6;11)(q23;q21)or(q25;q21)dn Translocation Uncertain significance
2 46;X;inv(X)(p11.4q24)dn inversion Pathogenic
3 46;XY;t(1;14)(q42;q13) Translocation Uncertain significance

Expression for Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for Exotropia

GO Terms for Exotropia

Biological processes related to Exotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.32 ACAN FBN1
2 dopaminergic neuron differentiation GO:0071542 9.26 PHOX2A PHOX2B
3 sympathetic nervous system development GO:0048485 9.16 PHOX2A PHOX2B
4 noradrenergic neuron differentiation GO:0003357 8.96 PHOX2A PHOX2B
5 parasympathetic nervous system development GO:0048486 8.62 PHOX2A PHOX2B

Molecular functions related to Exotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 ACAN FBN1

Sources for Exotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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