MCID: EXT022
MIFTS: 40

Exotropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Exotropia

MalaCards integrated aliases for Exotropia:

Name: Exotropia 12 76 29 6 15 73
Divergent Concomitant Strabismus 12
Divergent Strabismus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1143
ICD10 33 H50.1 H50.10
ICD9CM 35 378.1 378.10
MeSH 44 D005099
NCIt 50 C34601
SNOMED-CT 68 75400001
UMLS 73 C0015310

Summaries for Exotropia

MalaCards based summary : Exotropia, also known as divergent concomitant strabismus, is related to esotropia and strabismus. An important gene associated with Exotropia is TUBB3 (Tubulin Beta 3 Class III). The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid.

Wikipedia : 76 Exotropia is a form of strabismus where the eyes are deviated outward. It is the opposite of esotropia... more...

Related Diseases for Exotropia

Diseases related to Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 esotropia 32.3 CHN1 TUBB3
2 strabismus 30.6 CHN1 KIF21A PHOX2A TUBB3
3 hypertropia 30.3 CHN1 KIF21A TUBB3
4 ptosis 30.2 KIF21A PHOX2A TUBB3
5 amblyopia 30.1 CHN1 PHOX2A TUBB3
6 hypotropia 29.8 CHN1 KIF21A PHOX2A TUBB3
7 duane retraction syndrome 29.6 CHN1 KIF21A TNNI3K TUBB3
8 alternating exotropia 12.4
9 monocular exotropia 12.1
10 mehes syndrome 11.2
11 elsahy-waters syndrome 11.0
12 focal facial dermal dysplasia 3, setleis type 11.0
13 lowry-maclean syndrome 11.0
14 miles-carpenter syndrome 11.0
15 mental retardation smith fineman myers type 11.0
16 monocular esotropia 10.2
17 myopia 10.2
18 internuclear ophthalmoplegia 10.2
19 marcus gunn phenomenon 10.1 CHN1 TUBB3
20 chondroid chordoma 10.1 ACAN TUBB3
21 pectus excavatum 10.1 ACAN FBN1
22 moebius syndrome 10.1 PHOX2A TUBB3
23 keratopathy 10.1 FBN1 TUBB3
24 fibrosis of extraocular muscles, congenital, 2 10.1 KIF21A PHOX2A
25 aortic valve disease 1 10.1 ACAN CDH11 FBN1
26 enophthalmos 10.1 CHN1 TNNI3K
27 hypertelorism 10.1
28 mechanical strabismus 10.1
29 accommodative esotropia 10.1
30 facial paralysis 10.0 TNNI3K TUBB3
31 orbital disease 10.0 CHN1 TNNI3K
32 idiopathic scoliosis 10.0 ACAN FBN1
33 deafness, autosomal dominant 28 10.0 CHN1 KIF21A TUBB3
34 anisocoria 10.0
35 keratoconus 10.0
36 refractive error 10.0
37 supranuclear ocular palsy 10.0
38 isolated duane retraction syndrome 10.0
39 facial nerve disease 10.0 KIF21A PHOX2A TUBB3
40 autonomic nervous system disease 10.0 PHOX2A PHOX2B
41 kearns-sayre syndrome 10.0 KIF21A PHOX2A TUBB3
42 situs inversus 9.9
43 dextrocardia 9.9
44 paralytic squint 9.8 CHN1 KIF21A PHOX2A TUBB3
45 cranial nerve disease 9.8 CHN1 KIF21A PHOX2A TUBB3
46 crouzon syndrome 9.8
47 multiple sclerosis 9.8
48 duane retraction syndrome 1 9.8
49 frontonasal dysplasia 1 9.8
50 attention deficit-hyperactivity disorder 9.8

Graphical network of the top 20 diseases related to Exotropia:



Diseases related to Exotropia

Symptoms & Phenotypes for Exotropia

Drugs & Therapeutics for Exotropia

Drugs for Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Not Applicable 51-84-3 187
2 Botulinum Toxins Phase 4,Not Applicable
3 Acetylcholine Release Inhibitors Phase 4,Not Applicable
4 abobotulinumtoxinA Phase 4
5 onabotulinumtoxinA Phase 4
6 Botulinum Toxins, Type A Phase 4
7 Cholinergic Agents Phase 4,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
9 Neurotransmitter Agents Phase 4,Not Applicable
10 Neuromuscular Agents Phase 4
11 Pharmaceutical Solutions Phase 4
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
14
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
15 Central Nervous System Depressants Phase 2, Phase 3
16 Anesthetics, Local Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18 Anesthetics Phase 2, Phase 3,Not Applicable
19 Mydriatics Not Applicable
20 Autonomic Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
3 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
4 Comparison of Medial Rectus Resection and Plication in Exotropic Patients Not yet recruiting NCT03768362 Phase 2, Phase 3
5 Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
6 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries Unknown status NCT02450162
7 A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650 Not Applicable
8 Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness Completed NCT02131792 Not Applicable
9 A Novel Diagnostic Method for Exotropia Using Video-oculography Completed NCT03119311 Not Applicable
10 Observation Versus Occlusion Therapy for Intermittent Exotropia Completed NCT01032330 Not Applicable
11 Surgery and Convergence Insufficiency Intermittent Exotropia Completed NCT01435876 Not Applicable
12 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) Completed NCT02383381
13 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580 Not Applicable
14 Strabismus Surgery and Driving Ability Completed NCT02570555
15 Assessing the Functional and Psychosocial Impact of Strabismus in Asian Children Using the AS-20 and IXTQ Questionnaires Completed NCT01608828
16 Study of Surgical Treatment Versus Observation in Children With Moderate Intermittent Exotropia Recruiting NCT02736526 Not Applicable
17 Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02902887 Not Applicable
18 Trial of Overminus Spectacle Therapy for Intermittent Exotropia Recruiting NCT02807350 Not Applicable
19 The Effect of Oculo-Motor Exercises in Intermittent Exotropia Recruiting NCT03661476 Not Applicable
20 Basic Intermittent Exotropia and Risk Factors for Postoperative Overcorrection and Under Correction Recruiting NCT03153423 Not Applicable
21 Office Based Vergence and Accommodative Therapy and Intermittent Exotropia Active, not recruiting NCT03321838 Not Applicable
22 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603 Not Applicable
23 The Analysis of Ocular Deviations Between Dominant and Non-dominant Eye Using Video-oculography (VOG) in Intermittent Exotropia Enrolling by invitation NCT03641040 Not Applicable
24 Part-time Patch Therapy for Treatment of Intermittent Exotropia Not yet recruiting NCT03700632 Not Applicable
25 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836 Not Applicable
26 Botulinum Toxin Augmented Surgery vs Conventional Surgery in the Management of Large Angle Infantile Esotropia Not yet recruiting NCT03266549 Not Applicable
27 Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Terminated NCT02466659 Not Applicable

Search NIH Clinical Center for Exotropia

Genetic Tests for Exotropia

Genetic tests related to Exotropia:

# Genetic test Affiliating Genes
1 Exotropia 29

Anatomical Context for Exotropia

MalaCards organs/tissues related to Exotropia:

41
Eye, Testes, Thyroid, Brain, Pineal, Cortex

Publications for Exotropia

Articles related to Exotropia:

(show top 50) (show all 765)
# Title Authors Year
1
The difference of surgical outcomes between manifest exotropia and esotropia. ( 29922977 )
2018
2
Acute transient large-angle exotropia caused by traumatic orbital contusion. ( 29482420 )
2018
3
Infantile Exotropia and Developmental Delay. ( 29709041 )
2018
4
Effects of Surgical Assistant's Level of Resident Training on Surgical Treatment of Intermittent Exotropia: Operation Time and Surgical Outcomes. ( 29376227 )
2018
5
Comparison of the characteristics of patients with intermittent exotropia according to response to diagnostic monocular occlusion. ( 29383541 )
2018
6
Role of fusional convergence amplitude in postoperative phoria maintenance in children with intermittent exotropia. ( 29556848 )
2018
7
A quantitative analysis method for comitant exotropia using video-oculography with alternate cover. ( 29566654 )
2018
8
Clinical and Histopathologic Features of Consecutive Exotropia. ( 29494263 )
2018
9
Re: Economides etA al.: Capturing the moment of fusion loss in intermittent exotropia (Ophthalmology. 2017;124;496-504). ( 29389411 )
2018
10
Effect of combining inferior oblique muscle weakening procedures with exotropia surgery on the surgical correction of exotropia. ( 29795692 )
2018
11
Surgical Outcome of Intermittent Exotropia With Improvement in Control Grade Subsequent to Part-time Preoperative Occlusion Therapy. ( 28991346 )
2018
12
Bilateral lateral rectus recession versus unilateral recession resection for basic intermittent exotropia: a meta-analysis. ( 29368040 )
2018
13
Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study. ( 29675389 )
2018
14
Long-term Outcomes After Same Amount of Bilateral Rectus Muscle Recession for Intermittent Exotropia With the Same Angle of Deviation. ( 29913026 )
2018
15
Reduction of Consecutive Esotropia Using Modified Contralateral Recession and Resection for Recurrent Intermittent Exotropia. ( 28991342 )
2018
16
Clinical and surgical risk factors for consecutive exotropia. ( 29667435 )
2018
17
Early postoperative changes of motor alignment after surgery for intermittent exotropia. ( 29305730 )
2018
18
Long-term Surgical Outcomes of Initial Postoperative Overcorrection in Adults with Intermittent Exotropia. ( 29770641 )
2018
19
Esotropia and Exotropia Preferred Practice PatternAr. ( 29108746 )
2018
20
Analysis of alterations in white matter integrity of adult patients with comitant exotropia. ( 29569963 )
2018
21
Factors affecting surgical outcome of intermittent exotropia. ( 29675346 )
2018
22
Clinical study of the effect of refractive status on stereopsis in children with intermittent exotropia. ( 29921242 )
2018
23
The fast exodrift after the first surgical treatment of exotropia and its correlation with surgical outcome of second surgery. ( 29499664 )
2018
24
Congenital Bilateral Inferior Rectus Muscle Absence with A-type Exotropia. ( 29611375 )
2018
25
The clinical effect of surgical timing in infantile exotropia. ( 29526714 )
2018
26
Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia. ( 30025141 )
2018
27
Comparison of recurrent esotropia and consecutive exotropia with horizontal muscle reoperation in infantile esotropia. ( 30328559 )
2018
28
Divergence Excess Intermittent Exotropia: Long-Term Effect of Augmented Bilateral Lateral Rectus Recession. ( 28521562 )
2018
29
Optimal Surgical Results in Infantile Exotropia. ( 30024018 )
2018
30
Surgical outcomes of unilateral recession and resection in intermittent exotropia according to forced duction test results. ( 30048470 )
2018
31
Lateral rectus muscle recession for intermittent exotropia with anomalous head position in type 1 Duane's retraction syndrome. ( 30062561 )
2018
32
Postoperative changes of intermittent exotropia type as classified by 1-hour monocular occlusion. ( 30067770 )
2018
33
Subnormal Binocular Contrast Sensitivity Summation in Patients with Intermittent Exotropia. ( 30079006 )
2018
34
Characteristics of Patients Who Are Not Responsive to Alternate Patching for Overcorrected Intermittent Exotropia. ( 30091311 )
2018
35
Relation between early postoperative deviation and long-term outcome after unilateral lateral rectus recession and medial rectus resection for adult exotropia. ( 30140641 )
2018
36
Changes of corneal topographic measurements and higher-order aberrations after surgery for exotropia. ( 30142210 )
2018
37
Convergence, Accommodation, Fusion, and Stereopsis: What Keeps the Eyes Aligned in Intermittent Exotropia? ( 30147984 )
2018
38
Surgical results and factors affecting outcome in adult patients with sensory exotropia. ( 30154575 )
2018
39
Pathological Examination of Plicated Medial Rectus Muscle for Treatment of Re-recurrent Exotropia. ( 30180239 )
2018
40
A Randomized Trial Comparing Bilateral Lateral Rectus Recession versus Unilateral Recess and Resect for Basic-Type Intermittent Exotropia. ( 30189281 )
2018
41
Comparison of plication and resection in large-angle exotropia. ( 30240790 )
2018
42
Outcomes of undercorrection in surgical management and binocular vision gained of adult intermittent exotropia. ( 30254414 )
2018
43
Differences in the Stability and Amount of Postoperative Exodrift with Age after Unilateral Lateral Rectus Muscle Recession and Medial Rectus Muscle Resection of Intermittent Exotropia. ( 30369605 )
2018
44
Bilateral lateral rectus recession versus unilateral recession/resection for basic intermittent exotropia. ( 30395563 )
2018
45
Binocular coordination and reading performance during smartphone reading in intermittent exotropia. ( 30425446 )
2018
46
Intermittent Exotropia Treatment with Dichoptic Visual Training Using a Unique Virtual Reality Platform. ( 30457355 )
2018
47
Outcomes of bilateral lateral rectus recession in treatment of recurrent exotropia after bilateral medial rectus resection. ( 30460864 )
2018
48
Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection. ( 30522110 )
2018
49
A comparison of surgical outcomes between pre-and full-term patients with exotropia. ( 30532279 )
2018
50
Magnetic Resonance Imaging of a Medially Displaced Optic Nerve in a Rare Case of Extreme Exotropia. ( 30543355 )
2018

Variations for Exotropia

Expression for Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for Exotropia

GO Terms for Exotropia

Cellular components related to Exotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.13 ACAN AMTN FBN1
2 basement membrane GO:0005604 8.8 ACAN AMTN FBN1

Biological processes related to Exotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.43 ACAN CDH11 FBN1
2 dopaminergic neuron differentiation GO:0071542 9.32 PHOX2A PHOX2B
3 sympathetic nervous system development GO:0048485 9.16 PHOX2A PHOX2B
4 noradrenergic neuron differentiation GO:0003357 8.96 PHOX2A PHOX2B
5 parasympathetic nervous system development GO:0048486 8.62 PHOX2A PHOX2B

Sources for Exotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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