MCID: EXP002
MIFTS: 26

Exposure Keratitis

Categories: Neuronal diseases

Aliases & Classifications for Exposure Keratitis

MalaCards integrated aliases for Exposure Keratitis:

Name: Exposure Keratitis 12 15
Exposure Keratoconjunctivitis 12 70
Lagophthalmic Keratitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9461
ICD9CM 34 370.34
SNOMED-CT 67 14366000
ICD10 32 H16.21
UMLS 70 C0339295

Summaries for Exposure Keratitis

MalaCards based summary : Exposure Keratitis, also known as exposure keratoconjunctivitis, is related to keratitis, hereditary and hemifacial hyperplasia. An important gene associated with Exposure Keratitis is KERA (Keratocan). Affiliated tissues include eye, pituitary and skin, and related phenotypes are growth/size/body region and nervous system

Related Diseases for Exposure Keratitis

Diseases related to Exposure Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.4
2 hemifacial hyperplasia 10.1 FGFR2 EFNB1
3 beare-stevenson cutis gyrata syndrome 10.1 FGFR2 EFNB1
4 facial paralysis 10.1
5 exophthalmos 10.1 TSHR FGFR2
6 lagophthalmos 10.0
7 ectropion 10.0
8 keratopathy 10.0
9 craniosynostosis 1 9.9 TCF12 FGFR2
10 muenke syndrome 9.9 TCF12 FGFR2 EFNB1
11 apert syndrome 9.9 TCF12 FGFR2 EFNB1
12 jackson-weiss syndrome 9.9 FGFR2 EFNB1
13 saethre-chotzen syndrome 9.8 TCF12 FGFR2 EFNB1
14 synostosis 9.8 TCF12 FGFR2 EFNB1
15 strabismus 9.8
16 yemenite deaf-blind hypopigmentation syndrome 9.8
17 ptosis 9.8
18 congenital ptosis 9.8
19 entropion 9.8
20 acoustic neuroma 9.8
21 cicatricial ectropion 9.8
22 neuroma 9.8
23 cataract 9.8
24 mechanical strabismus 9.8
25 mitochondrial metabolism disease 9.8 NDUFA1 MT-ND4
26 craniosynostosis 9.8 TCF12 FGFR2 EFNB1
27 skin disease 9.4 HBEGF GJB4 FGFR2 ABCA12

Comorbidity relations with Exposure Keratitis via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Exposure Keratitis:



Diseases related to Exposure Keratitis

Symptoms & Phenotypes for Exposure Keratitis

MGI Mouse Phenotypes related to Exposure Keratitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 ABCA12 EFNB1 FGFR2 GJB4 HBEGF KERA
2 nervous system MP:0003631 9.23 EFNB1 FGFR2 HBEGF LGR4 NDUFA1 TCF12

Drugs & Therapeutics for Exposure Keratitis

Search Clinical Trials , NIH Clinical Center for Exposure Keratitis

Genetic Tests for Exposure Keratitis

Anatomical Context for Exposure Keratitis

MalaCards organs/tissues related to Exposure Keratitis:

40
Eye, Pituitary, Skin

Publications for Exposure Keratitis

Articles related to Exposure Keratitis:

(show top 50) (show all 200)
# Title Authors PMID Year
1
Corneal Neurotization in the Setting of Facial Paralysis: A Comprehensive Review of Surgical Techniques. 61
33654040 2021
2
Retrospective analysis of ocular disease in a population of captive pteropodid bats, 2003-2020. 61
33682341 2021
3
Surgical correction of severe congenital ptosis using a modified frontalis muscle advancement technique: A single-arm trial. 61
33624537 2021
4
Vision and Ocular Surface Salvage in Extreme Post-Burn Cicatricial Ectropion with Infectious Exposure Keratitis. 61
33528555 2021
5
Comparative evaluation of conventional and modified frontalis muscle flap advancement techniques in the treatment of severe congenital ptosis: A retrospective cohort study. 61
33529243 2021
6
Use of a chronic soft tissue expansion device to facilitate blepharoplasty in a horse with lower-lid cicatricial ectropion with a 14-year follow-up. 61
32687627 2020
7
Improved Function of Orbicularis Oculi by Dynamic Transfer of Contralateral Orbicularis Oculi Muscle in Patients with Facial Palsy. 61
33488012 2020
8
Autologous dermis graft versus conchal cartilage graft for managing lower eyelid retraction: A comparative study. 61
32530712 2020
9
Frontalis Linkage Without Intraoperative Eyelid Elevation for the Management of Myopathic Ptosis. 61
31809486 2020
10
Surgical Treatment of Severe Ptosis by Modified Brow Suspension Technique. 61
32110644 2020
11
[Clinical application of modified kite flap in treatment of divided nevus of lateral canthus]. 61
31823558 2019
12
Management of ocular manifestations of autosomal recessive congenital ichthyosis 4B, harlequin type, in the perinatal period. 61
31586585 2019
13
Bilateral orbital involvement of IgG4-related disease detected on 18F-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography: A Clinical Case Report. 61
31764855 2019
14
45 GyRBE for group III orbital embryonal rhabdomyosarcoma. 61
31530120 2019
15
Clinical findings of traumatic proptosis in small-breed dogs and complications associated with globe replacement surgery. 61
31998615 2019
16
Long-Term Ophthalmic Outcomes in Pediatric Orbital Cellulitis: A Prospective, Multidisciplinary Study From a Tertiary-Care Referral Institute. 61
31545868 2019
17
The role of autophagy in the pathogenesis of exposure keratitis. 61
30973208 2019
18
Topical insulin in neurotrophic keratopathy after resection of acoustic neuroma. 61
30025986 2019
19
Ophthalmologic Complications Associated With Oculofacial Plastic and Esthetic Surgeries. 61
29554075 2018
20
Surgical Outcome After Less "Rigid" Fixation in Open Cranial Vault Remodeling for Craniosynostosis. 61
29438206 2018
21
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. 61
29346172 2018
22
Clinical Description, Molecular Analysis of TWIST2 Gene, and Surgical Treatment in a Patient With Barber-Say Syndrome. 61
29329175 2018
23
EyePrintPRO therapeutic scleral contact lens: indications and outcomes. 61
29426444 2018
24
Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study. 61
29670328 2018
25
Elevated Aqueous Cytokine Levels in Eyes With Ocular Surface Diseases. 61
28988898 2017
26
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. 61
28815772 2017
27
A Modified Levator Resection Technique Involving Retention of the Levator Palpebrae Superioris Muscle Suspension System for Treatment of Congenital Ptosis. 61
28378186 2017
28
Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy. 61
27171131 2017
29
Erratum: A non-surgical approach to the management of exposure keratitis due to facial palsy by using mini-scleral lenses: Erratum. 61
31305667 2017
30
Evaluation of moderate and severe blepharoptosis correction using the interdigitated part of the frontalis muscle and orbicularis oculi muscle suspension technique: A cohort study of 235 cases. 61
28254497 2017
31
A non-surgical approach to the management of exposure keratitis due to facial palsy by using mini-scleral lenses. 61
28178141 2017
32
Outcomes of Two Surgical Techniques Using Silicone Rod for Frontalis Sling Suspension to Treat Severe Ptosis. 61
27783094 2017
33
The ophthalmic sequelae of Pfeiffer syndrome and the long-term visual outcomes after craniofacial surgery. 61
27418250 2016
34
[Pituitary syndrome caused by neoplasia in a 17-month-old Holstein Friesian heifer]. 61
27172846 2016
35
Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results. 61
26606867 2016
36
Temporalis Muscle Transfer for the Treatment of Lagophthalmos in Patients With Leprosy: Refinement in Surgical Techniques to Prevent Postoperative Ptosis. 61
26674897 2016
37
Upper and Lower Eyelid Full Thickness Reconstruction Using a Retrograde Postauricular Island Flap. 61
26352361 2015
38
Oncologic surgery of the eyelid and orbital region. 61
25701895 2015
39
Retrobulbar abscess in a child. 61
26007271 2015
40
Treatment of the periocular complex in paralytic lagophthalmos. 61
25480756 2015
41
MEDICAL AND NEUROLOGICAL COMPLICATIONS AMONG STROKE PATIENTS ADMITTED FOR INPATIENT CARE IN ADDIS ABABA, ETHIOPIA. 61
26591287 2015
42
Endophthalmitis due to an intra-ocular linear foreign body in a cat. 61
28491351 2015
43
The use of Whitnall's ligament for sling redirection in frontalis suspension ptosis surgery. 61
24896775 2015
44
[Keratopathy versus allergic eye disease: misdiagnosis leading to keratitis]. 61
25497650 2014
45
Transnasal endoscopic orbital decompression: 15-year clinical experience in Southern Taiwan. 61
24704350 2014
46
Ocular manifestations of head injury and incidence of post-traumatic ocular motor nerve involvement in cases of head injury: a clinical review. 61
24469117 2014
47
Paralytic ectropion treatment with lateral periosteal flap canthoplasty and introduction of the ectropion severity score. 61
25289344 2014
48
Long-term visual outcomes in patients with orbitotemporal neurofibromatosis. 61
23926960 2014
49
In the eyes of the law: malpractice litigation in oculoplastic surgery. 61
24618906 2014
50
Effect of orbital decompression on diplopia in thyroid-related orbitopathy. 61
24481502 2014

Variations for Exposure Keratitis

Expression for Exposure Keratitis

Search GEO for disease gene expression data for Exposure Keratitis.

Pathways for Exposure Keratitis

GO Terms for Exposure Keratitis

Cellular components related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.61 TSHR NDUFA1 MT-ND4 LGR4 HBEGF GJB4
2 mitochondrial respiratory chain complex I GO:0005747 9.16 NDUFA1 MT-ND4
3 integral component of plasma membrane GO:0005887 9.1 TSHR LGR4 HBEGF GJB4 FGFR2 EFNB1

Biological processes related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.43 TSHR LGR4
2 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.4 NDUFA1 MT-ND4
3 bone mineralization GO:0030282 9.37 LGR4 FGFR2
4 activation of adenylate cyclase activity GO:0007190 9.32 TSHR LGR4
5 lung alveolus development GO:0048286 9.26 FGFR2 ABCA12
6 digestive tract development GO:0048565 9.16 LGR4 FGFR2
7 embryonic pattern specification GO:0009880 8.96 FGFR2 EFNB1
8 cell-cell signaling GO:0007267 8.92 TSHR GJB4 FGFR2 EFNB1

Molecular functions related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.16 NDUFA1 MT-ND4
2 G protein-coupled peptide receptor activity GO:0008528 8.96 TSHR LGR4
3 protein-hormone receptor activity GO:0016500 8.62 TSHR LGR4

Sources for Exposure Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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