MCID: EXP002
MIFTS: 32

Exposure Keratitis

Categories: Eye diseases

Aliases & Classifications for Exposure Keratitis

MalaCards integrated aliases for Exposure Keratitis:

Name: Exposure Keratitis 12 15
Exposure Keratoconjunctivitis 12 74
Lagophthalmic Keratitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9461
ICD9CM 36 370.34
SNOMED-CT 69 14366000
ICD10 34 H16.21
UMLS 74 C0339295

Summaries for Exposure Keratitis

MalaCards based summary : Exposure Keratitis, also known as exposure keratoconjunctivitis, is related to corneal dystrophy, congenital stromal and keratitis, hereditary. An important gene associated with Exposure Keratitis is KERA (Keratocan), and among its related pathways/superpathways are Interleukin-10 signaling and Malaria. The drugs Acetylcholine and Acetylcholine Release Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and nk cells, and related phenotypes are integument and respiratory system

Related Diseases for Exposure Keratitis

Graphical network of the top 20 diseases related to Exposure Keratitis:



Diseases related to Exposure Keratitis

Symptoms & Phenotypes for Exposure Keratitis

MGI Mouse Phenotypes related to Exposure Keratitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.43 BGN HBEGF IL13 SELE SELP TWIST2
2 respiratory system MP:0005388 9.02 HBEGF IL13 SELE SELP TWIST2

Drugs & Therapeutics for Exposure Keratitis

Drugs for Exposure Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
2 Acetylcholine Release Inhibitors Phase 2, Phase 3
3 Peripheral Nervous System Agents Phase 2, Phase 3
4 Neurotransmitter Agents Phase 2, Phase 3
5 Neuromuscular Agents Phase 2, Phase 3
6 abobotulinumtoxinA Phase 2, Phase 3
7 Botulinum Toxins, Type A Phase 2, Phase 3
8 Cholinergic Agents Phase 2, Phase 3
9 Botulinum Toxins Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
2 Comparison Study Between Two Techniques for Correction of Upper Lid Retraction in Patients With Grave's Orbitopathy Unknown status NCT01999790 Not Applicable
3 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734 Not Applicable

Search NIH Clinical Center for Exposure Keratitis

Genetic Tests for Exposure Keratitis

Anatomical Context for Exposure Keratitis

MalaCards organs/tissues related to Exposure Keratitis:

42
Eye, Thyroid, Nk Cells

Publications for Exposure Keratitis

Articles related to Exposure Keratitis:

(show all 13)
# Title Authors Year
1
The role of autophagy in the pathogenesis of exposure keratitis. ( 30973208 )
2019
2
A non-surgical approach to the management of exposure keratitis due to facial palsy by using mini-scleral lenses. ( 28178141 )
2017
3
Treatment of refractory exposure keratitis with modified medial tarsorrhaphy using tarsoconjunctival flap. ( 23254485 )
2013
4
Infantile facial palsy with exposure keratitis. ( 19791733 )
2009
5
Adult-onset exposure keratitis after childhood ptosis repair with frontalis sling procedure. ( 19606162 )
2009
6
Lateral canthoplasty for facial nerve paralysis and exposure keratitis in a mouse. ( 11599815 )
2001
7
Cicatricial, postburn ectropion and exposure keratitis. ( 9601594 )
1998
8
Acinetobacter exposure keratitis. ( 8060938 )
1994
9
Exposure keratitis in comatose children. ( 2527927 )
1989
10
Exposure keratitis following cataract surgery on the fellow eye. ( 3444602 )
1987
11
Premature eyelid opening and exposure keratitis in a puppy. ( 4495039 )
1974
12
A SILICONE RUBBER SHIELD FOR EXPOSURE KERATITIS. ( 14259928 )
1965
13
Thin plastic shield for prevention of exposure keratitis. ( 13948708 )
1963

Variations for Exposure Keratitis

Expression for Exposure Keratitis

Search GEO for disease gene expression data for Exposure Keratitis.

Pathways for Exposure Keratitis

Pathways related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 CCL4 IL13
2 10.65 SELE SELP
3 10.03 CCL4 CCL4L1 IL13

GO Terms for Exposure Keratitis

Cellular components related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CCL4 CCL4L1 HBEGF IL13 SELE SELP
2 mitochondrial respiratory chain complex I GO:0005747 8.96 MT-ND4 NDUFA1

Biological processes related to Exposure Keratitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.5 IL13 SELE SELP
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.49 SELE SELP
3 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.48 MT-ND4 NDUFA1
4 monocyte chemotaxis GO:0002548 9.46 CCL4 CCL4L1
5 response to nicotine GO:0035094 9.43 IL13 MT-ND4
6 lymphocyte chemotaxis GO:0048247 9.4 CCL4 CCL4L1
7 leukocyte cell-cell adhesion GO:0007159 9.37 SELE SELP
8 regulation of signaling receptor activity GO:0010469 9.33 CCL4 HBEGF IL13
9 eosinophil chemotaxis GO:0048245 9.26 CCL4 CCL4L1
10 inflammatory response GO:0006954 9.02 CCL4 CCL4L1 IL13 SELE SELP
11 leukocyte tethering or rolling GO:0050901 8.96 SELE SELP

Molecular functions related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.32 CCL4 CCL4L1
2 NADH dehydrogenase (ubiquinone) activity GO:0008137 9.26 MT-ND4 NDUFA1
3 CCR chemokine receptor binding GO:0048020 9.16 CCL4 CCL4L1
4 oligosaccharide binding GO:0070492 8.96 SELE SELP
5 sialic acid binding GO:0033691 8.62 SELE SELP

Sources for Exposure Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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