MCID: EXP002
MIFTS: 26

Exposure Keratitis

Categories: Eye diseases

Aliases & Classifications for Exposure Keratitis

MalaCards integrated aliases for Exposure Keratitis:

Name: Exposure Keratitis 12 15
Exposure Keratoconjunctivitis 12 73
Lagophthalmic Keratitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9461
ICD10 33 H16.21
ICD9CM 35 370.34
SNOMED-CT 68 14366000
UMLS 73 C0339295

Summaries for Exposure Keratitis

MalaCards based summary : Exposure Keratitis, also known as exposure keratoconjunctivitis, is related to corneal dystrophy, congenital stromal and grange syndrome. An important gene associated with Exposure Keratitis is KERA (Keratocan), and among its related pathways/superpathways is G-protein signaling_RhoB regulation pathway. The drugs Acetylcholine and onabotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye and nk cells, and related phenotype is respiratory system.

Related Diseases for Exposure Keratitis

Graphical network of the top 20 diseases related to Exposure Keratitis:



Diseases related to Exposure Keratitis

Symptoms & Phenotypes for Exposure Keratitis

MGI Mouse Phenotypes related to Exposure Keratitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 HBEGF IL13 SELE SELP TUBB3 TWIST2

Drugs & Therapeutics for Exposure Keratitis

Drugs for Exposure Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
2 onabotulinumtoxinA Phase 2, Phase 3
3 abobotulinumtoxinA Phase 2, Phase 3
4 Peripheral Nervous System Agents Phase 2, Phase 3
5 Neurotransmitter Agents Phase 2, Phase 3
6 Cholinergic Agents Phase 2, Phase 3
7 Acetylcholine Release Inhibitors Phase 2, Phase 3
8 Botulinum Toxins, Type A Phase 2, Phase 3
9 Neuromuscular Agents Phase 2, Phase 3
10 Botulinum Toxins Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
2 Comparison Study Between Two Techniques for Correction of Upper Lid Retraction in Patients With Grave's Orbitopathy Unknown status NCT01999790 Not Applicable
3 A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill Completed NCT00513734 Not Applicable

Search NIH Clinical Center for Exposure Keratitis

Genetic Tests for Exposure Keratitis

Anatomical Context for Exposure Keratitis

MalaCards organs/tissues related to Exposure Keratitis:

41
Eye, Nk Cells

Publications for Exposure Keratitis

Articles related to Exposure Keratitis:

(show all 12)
# Title Authors Year
1
A non-surgical approach to the management of exposure keratitis due to facial palsy by using mini-scleral lenses. ( 28178141 )
2017
2
Treatment of refractory exposure keratitis with modified medial tarsorrhaphy using tarsoconjunctival flap. ( 23254485 )
2013
3
Infantile facial palsy with exposure keratitis. ( 19791733 )
2009
4
Adult-onset exposure keratitis after childhood ptosis repair with frontalis sling procedure. ( 19606162 )
2009
5
Lateral canthoplasty for facial nerve paralysis and exposure keratitis in a mouse. ( 11599815 )
2001
6
Cicatricial, postburn ectropion and exposure keratitis. ( 9601594 )
1998
7
Acinetobacter exposure keratitis. ( 8060938 )
1994
8
Exposure keratitis in comatose children. ( 2527927 )
1989
9
Exposure keratitis following cataract surgery on the fellow eye. ( 3444602 )
1987
10
Premature eyelid opening and exposure keratitis in a puppy. ( 4495039 )
1974
11
A SILICONE RUBBER SHIELD FOR EXPOSURE KERATITIS. ( 14259928 )
1965
12
Thin plastic shield for prevention of exposure keratitis. ( 13948708 )
1963

Variations for Exposure Keratitis

Expression for Exposure Keratitis

Search GEO for disease gene expression data for Exposure Keratitis.

Pathways for Exposure Keratitis

Pathways related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.03 CCL4 CCL4L1 IL13

GO Terms for Exposure Keratitis

Cellular components related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CCL4 CCL4L1 HBEGF IL13 SELE SELP

Biological processes related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.62 CCL4 CCL4L1 HBEGF IL13
2 response to lipopolysaccharide GO:0032496 9.54 IL13 SELE SELP
3 response to nicotine GO:0035094 9.46 IL13 MT-ND4
4 lymphocyte chemotaxis GO:0048247 9.43 CCL4 CCL4L1
5 leukocyte cell-cell adhesion GO:0007159 9.4 SELE SELP
6 inflammatory response GO:0006954 9.35 CCL4 CCL4L1 IL13 SELE SELP
7 eosinophil chemotaxis GO:0048245 9.26 CCL4 CCL4L1
8 leukocyte tethering or rolling GO:0050901 9.16 SELE SELP
9 negative regulation of NAD(P)H oxidase activity GO:0033861 8.62 DRD5 IL13

Molecular functions related to Exposure Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR chemokine receptor binding GO:0048020 9.16 CCL4 CCL4L1
2 oligosaccharide binding GO:0070492 8.96 SELE SELP
3 sialic acid binding GO:0033691 8.62 SELE SELP

Sources for Exposure Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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