MCID: EXP001
MIFTS: 24

Expressive Language Disorder

Categories: Mental diseases

Aliases & Classifications for Expressive Language Disorder

MalaCards integrated aliases for Expressive Language Disorder:

Name: Expressive Language Disorder 12 15
Developmental Expressive Language Disorder 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11385
ICD10 33 F80.1
ICD9CM 35 315.31
NCIt 50 C92562
UMLS 73 C0236826

Summaries for Expressive Language Disorder

Disease Ontology : 12 A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits.

MalaCards based summary : Expressive Language Disorder, also known as developmental expressive language disorder, is related to mixed receptive-expressive language disorder and dysphasia, familial developmental. An important gene associated with Expressive Language Disorder is FOXP2 (Forkhead Box P2), and among its related pathways/superpathways is Neuroscience.

Wikipedia : 76 Expressive language disorder is a communication disorder in which there are difficulties with verbal and... more...

Related Diseases for Expressive Language Disorder

Diseases related to Expressive Language Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 mixed receptive-expressive language disorder 12.6
2 dysphasia, familial developmental 10.3
3 amyotrophic lateral sclerosis type 6 10.0 FUS TARDBP
4 amyotrophic lateral sclerosis 18 10.0 FUS TARDBP
5 amyotrophic lateral sclerosis type 14 10.0 FUS TARDBP
6 lethal congenital contracture syndrome 1 10.0 FUS TARDBP
7 amyotrophic lateral sclerosis 21 10.0 FUS TARDBP
8 amyotrophic lateral sclerosis 11 10.0 FUS TARDBP
9 amyotrophic lateral sclerosis 7 9.9 FUS TARDBP
10 anterior horn cell disease 9.9 FUS TARDBP
11 amyotrophic lateral sclerosis 9 9.9 FUS TARDBP
12 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 9.8 FUS TARDBP
13 reading disorder 9.8 FOXP2 PSEN1
14 spinocerebellar ataxia 31 9.8 FUS TARDBP
15 internuclear ophthalmoplegia 9.7 NF1 PSEN1
16 phonagnosia 9.7 PSEN1 TARDBP
17 aphasia 9.7 FOXP2 PSEN1
18 associative agnosia 9.7 PSEN1 TARDBP
19 writing disorder 9.7 PSEN1 TARDBP
20 alexia 9.7 PSEN1 TARDBP
21 autism 9.7
22 aging 9.7
23 semantic dementia 9.6 PSEN1 TARDBP
24 apraxia 9.6 FOXP2 PSEN1
25 agraphia 9.5 PSEN1 TARDBP
26 specific developmental disorder 9.5 FOXP2 PSEN1
27 supranuclear palsy, progressive, 1 9.4 PSEN1 TARDBP
28 dementia, lewy body 9.1 PSEN1 TARDBP
29 ideomotor apraxia 9.1 FUS PSEN1 TARDBP
30 nominal aphasia 9.1 FUS PSEN1 TARDBP
31 basal ganglia disease 9.1 FUS PSEN1 TARDBP
32 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.1 FUS PSEN1 TARDBP
33 pick disease of brain 9.1 FUS PSEN1 TARDBP
34 central nervous system disease 9.1 FUS PSEN1 TARDBP
35 nervous system disease 9.1 FUS PSEN1 TARDBP
36 frontotemporal dementia 9.0 FUS PSEN1 TARDBP
37 dementia 9.0 FUS PSEN1 TARDBP
38 trehalase deficiency 8.9 FOXP2 FUS NF1
39 amyotrophic lateral sclerosis 1 8.8 FUS PSEN1 TARDBP
40 speech and communication disorders 8.6 FOXP2 FUS PSEN1 TARDBP

Comorbidity relations with Expressive Language Disorder via Phenotypic Disease Network (PDN):


Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation

Graphical network of the top 20 diseases related to Expressive Language Disorder:



Diseases related to Expressive Language Disorder

Symptoms & Phenotypes for Expressive Language Disorder

Drugs & Therapeutics for Expressive Language Disorder

Search Clinical Trials , NIH Clinical Center for Expressive Language Disorder

Genetic Tests for Expressive Language Disorder

Anatomical Context for Expressive Language Disorder

Publications for Expressive Language Disorder

Articles related to Expressive Language Disorder:

# Title Authors Year
1
Sensorimotor function in preschool-aged children with expressive language disorder. ( 24685939 )
2014
2
Is expressive language disorder an accurate diagnostic category? ( 19029534 )
2009
3
Comparative study of early childhood high-function autism and developmental mixed receptive-expressive language disorder. ( 15481561 )
2004
4
Expressive language disorder after infarction of left lentiform nucleus. ( 10942673 )
2000
5
Behavioral correlates of developmental expressive language disorder. ( 2745899 )
1989

Variations for Expressive Language Disorder

Expression for Expressive Language Disorder

Search GEO for disease gene expression data for Expressive Language Disorder.

Pathways for Expressive Language Disorder

Pathways related to Expressive Language Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 NF1 PSEN1 TARDBP

GO Terms for Expressive Language Disorder

Cellular components related to Expressive Language Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.63 DCXR FOXP2 FUS NF1 PSEN1 TARDBP
2 presynapse GO:0098793 8.96 NF1 PSEN1
3 dendrite GO:0030425 8.8 FUS NF1 PSEN1

Biological processes related to Expressive Language Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.4 NF1 PSEN1
2 post-embryonic development GO:0009791 9.37 FOXP2 PSEN1
3 negative regulation of protein phosphorylation GO:0001933 9.32 PSEN1 TARDBP
4 forebrain development GO:0030900 9.26 FOXP2 PSEN1
5 skeletal muscle tissue development GO:0007519 9.16 FOXP2 NF1
6 smooth muscle tissue development GO:0048745 8.96 FOXP2 NF1
7 cerebral cortex development GO:0021987 8.8 FOXP2 NF1 PSEN1

Molecular functions related to Expressive Language Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 DCXR FOXP2 FUS TARDBP

Sources for Expressive Language Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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