MCID: EXP001
MIFTS: 20

Expressive Language Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Expressive Language Disorder

MalaCards integrated aliases for Expressive Language Disorder:

Name: Expressive Language Disorder 12 15
Developmental Expressive Language Disorder 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11385
ICD9CM 36 315.31
NCIt 51 C92562
SNOMED-CT 69 80360005
ICD10 34 F80.1
UMLS 74 C0236826

Summaries for Expressive Language Disorder

Disease Ontology : 12 A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits.

MalaCards based summary : Expressive Language Disorder, also known as developmental expressive language disorder, is related to mixed receptive-expressive language disorder and dysphasia, familial developmental. An important gene associated with Expressive Language Disorder is SLC6A8 (Solute Carrier Family 6 Member 8). Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Expressive language disorder is a communication disorder in which there are difficulties with verbal and... more...

Related Diseases for Expressive Language Disorder

Diseases related to Expressive Language Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mixed receptive-expressive language disorder 12.8
2 dysphasia, familial developmental 10.5
3 autism 9.8
4 specific developmental disorder 9.7 FOXP2 SLC6A8

Comorbidity relations with Expressive Language Disorder via Phenotypic Disease Network (PDN):


Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation

Symptoms & Phenotypes for Expressive Language Disorder

GenomeRNAi Phenotypes related to Expressive Language Disorder according to GeneCards Suite gene sharing:

27 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.89 FOXP2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.89 NF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.89 FUS NF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.89 FOXP2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.89 FOXP2 SLC6A8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.89 NF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.89 FOXP2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.89 SLC6A8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.89 FUS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.89 FOXP2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.89 FUS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.89 FOXP2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.89 FUS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.89 FOXP2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.89 SLC6A8
16 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.44 SLC6A8
17 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.44 SLC6A8
18 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.44 SLC6A8
19 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.44 SLC6A8
20 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.44 SLC6A8
21 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.44 NF1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.44 NF1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.44 SLC6A8
24 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.44 SLC6A8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.44 NF1 SLC6A8
26 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.44 SLC6A8
27 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.44 NF1

Drugs & Therapeutics for Expressive Language Disorder

Search Clinical Trials , NIH Clinical Center for Expressive Language Disorder

Genetic Tests for Expressive Language Disorder

Anatomical Context for Expressive Language Disorder

Publications for Expressive Language Disorder

Articles related to Expressive Language Disorder:

# Title Authors Year
1
Sensorimotor function in preschool-aged children with expressive language disorder. ( 24685939 )
2014
2
Is expressive language disorder an accurate diagnostic category? ( 19029534 )
2009
3
Comparative study of early childhood high-function autism and developmental mixed receptive-expressive language disorder. ( 15481561 )
2004
4
Expressive language disorder after infarction of left lentiform nucleus. ( 10942673 )
2000
5
Behavioral correlates of developmental expressive language disorder. ( 2745899 )
1989

Variations for Expressive Language Disorder

Expression for Expressive Language Disorder

Search GEO for disease gene expression data for Expressive Language Disorder.

Pathways for Expressive Language Disorder

GO Terms for Expressive Language Disorder

Biological processes related to Expressive Language Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 9.16 FOXP2 NF1
2 skeletal muscle tissue development GO:0007519 8.96 FOXP2 NF1
3 smooth muscle tissue development GO:0048745 8.62 FOXP2 NF1

Molecular functions related to Expressive Language Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 DCXR FOXP2 FUS

Sources for Expressive Language Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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