Expressive Language Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Expressive Language Disorder

MalaCards integrated aliases for Expressive Language Disorder:

Name: Expressive Language Disorder ¹² ¹⁵

Developmental Expressive Language Disorder ¹² ⁷³

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Mental and behavioural disorders

Disorders of psychological development

Specific developmental disorders of speech and language

Expressive language disorder

External Ids:

Disease Ontology ¹² DOID:11385

ICD10 ³³ F80.1

ICD9CM ³⁵ 315.31

NCIt ⁵⁰ C92562

SNOMED-CT ⁶⁸ 192565006 229733002 268734000 more

UMLS ⁷³ C0236826

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Summaries for Expressive Language Disorder

Disease Ontology : ¹² A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits.

MalaCards based summary : Expressive Language Disorder, also known as developmental expressive language disorder, is related to mixed receptive-expressive language disorder and dysphasia, familial developmental. An important gene associated with Expressive Language Disorder is FOXP2 (Forkhead Box P2), and among its related pathways/superpathways is Neuroscience.

Wikipedia : ⁷⁶ Expressive language disorder is a communication disorder in which there are difficulties with verbal and... more...

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Related Diseases for Expressive Language Disorder

Diseases related to Expressive Language Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)

#	Related Disease	Score	Top Affiliating Genes
1	mixed receptive-expressive language disorder	12.6
2	dysphasia, familial developmental	10.3
3	amyotrophic lateral sclerosis type 6	10.0	FUS TARDBP
4	amyotrophic lateral sclerosis 18	10.0	FUS TARDBP
5	amyotrophic lateral sclerosis type 14	10.0	FUS TARDBP
6	lethal congenital contracture syndrome 1	10.0	FUS TARDBP
7	amyotrophic lateral sclerosis 21	10.0	FUS TARDBP
8	amyotrophic lateral sclerosis 11	10.0	FUS TARDBP
9	amyotrophic lateral sclerosis 7	9.9	FUS TARDBP
10	anterior horn cell disease	9.9	FUS TARDBP
11	amyotrophic lateral sclerosis 9	9.9	FUS TARDBP
12	amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	9.8	FUS TARDBP
13	reading disorder	9.8	FOXP2 PSEN1
14	spinocerebellar ataxia 31	9.8	FUS TARDBP
15	internuclear ophthalmoplegia	9.7	NF1 PSEN1
16	phonagnosia	9.7	PSEN1 TARDBP
17	aphasia	9.7	FOXP2 PSEN1
18	associative agnosia	9.7	PSEN1 TARDBP
19	writing disorder	9.7	PSEN1 TARDBP
20	alexia	9.7	PSEN1 TARDBP
21	autism	9.7
22	aging	9.7
23	semantic dementia	9.6	PSEN1 TARDBP
24	apraxia	9.6	FOXP2 PSEN1
25	agraphia	9.5	PSEN1 TARDBP
26	specific developmental disorder	9.5	FOXP2 PSEN1
27	supranuclear palsy, progressive, 1	9.4	PSEN1 TARDBP
28	dementia, lewy body	9.1	PSEN1 TARDBP
29	ideomotor apraxia	9.1	FUS PSEN1 TARDBP
30	nominal aphasia	9.1	FUS PSEN1 TARDBP
31	basal ganglia disease	9.1	FUS PSEN1 TARDBP
32	frontotemporal dementia and/or amyotrophic lateral sclerosis 1	9.1	FUS PSEN1 TARDBP
33	pick disease of brain	9.1	FUS PSEN1 TARDBP
34	central nervous system disease	9.1	FUS PSEN1 TARDBP
35	nervous system disease	9.1	FUS PSEN1 TARDBP
36	frontotemporal dementia	9.0	FUS PSEN1 TARDBP
37	dementia	9.0	FUS PSEN1 TARDBP
38	trehalase deficiency	8.9	FOXP2 FUS NF1
39	amyotrophic lateral sclerosis 1	8.8	FUS PSEN1 TARDBP
40	speech and communication disorders	8.6	FOXP2 FUS PSEN1 TARDBP

Comorbidity relations with Expressive Language Disorder via Phenotypic Disease Network (PDN):

Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation

Graphical network of the top 20 diseases related to Expressive Language Disorder:

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Symptoms & Phenotypes for Expressive Language Disorder

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Drugs & Therapeutics for Expressive Language Disorder

Search Clinical Trials , NIH Clinical Center for Expressive Language Disorder

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Genetic Tests for Expressive Language Disorder

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Anatomical Context for Expressive Language Disorder

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Publications for Expressive Language Disorder

Articles related to Expressive Language Disorder:

#	Title	Authors	Year
1	Sensorimotor function in preschool-aged children with expressive language disorder. ( 24685939 )	MA1A1rsepp I....PAoAosuke M.	2014
2	Is expressive language disorder an accurate diagnostic category? ( 19029534 )	Leonard L.B.	2009
3	Comparative study of early childhood high-function autism and developmental mixed receptive-expressive language disorder. ( 15481561 )	Yang P....Chen C.S.	2004
4	Expressive language disorder after infarction of left lentiform nucleus. ( 10942673 )	Warren J.D....Waddy H.M.	2000
5	Behavioral correlates of developmental expressive language disorder. ( 2745899 )	Caulfield M.B....Whitehurst G.J.	1989

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Genes for Expressive Language Disorder

Genes related to Expressive Language Disorder (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FOXP2	Forkhead Box P2	Protein Coding	15.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	DCXR	Dicarbonyl And L-Xylulose Reductase	Protein Coding	15.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	FUS	FUS RNA Binding Protein	Protein Coding	14.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	TARDBP	TAR DNA Binding Protein	Protein Coding	14.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PSEN1	Presenilin 1	Protein Coding	14.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	NF1	Neurofibromin 1	Protein Coding	14.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Expressive Language Disorder

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Expression for Expressive Language Disorder

Search GEO for disease gene expression data for Expressive Language Disorder.

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Pathways for Expressive Language Disorder

Pathways related to Expressive Language Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	11.33	NF1 PSEN1 TARDBP

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GO Terms for Expressive Language Disorder

Cellular components related to Expressive Language Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.63	DCXR FOXP2 FUS NF1 PSEN1 TARDBP
2	presynapse	GO:0098793	8.96	NF1 PSEN1
3	dendrite	GO:0030425	8.8	FUS NF1 PSEN1

Biological processes related to Expressive Language Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of protein kinase activity	GO:0006469	9.4	NF1 PSEN1
2	post-embryonic development	GO:0009791	9.37	FOXP2 PSEN1
3	negative regulation of protein phosphorylation	GO:0001933	9.32	PSEN1 TARDBP
4	forebrain development	GO:0030900	9.26	FOXP2 PSEN1
5	skeletal muscle tissue development	GO:0007519	9.16	FOXP2 NF1
6	smooth muscle tissue development	GO:0048745	8.96	FOXP2 NF1
7	cerebral cortex development	GO:0021987	8.8	FOXP2 NF1 PSEN1

Molecular functions related to Expressive Language Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	8.92	DCXR FOXP2 FUS TARDBP

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Sources for Expressive Language Disorder

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⁷⁶ Wikipedia