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MCID: EXP001
MIFTS: 23

Expressive Language Disorder

Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications
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Aliases & Classifications for Expressive Language Disorder

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MalaCards integrated aliases for Expressive Language Disorder:

Name: Expressive Language Disorder 12 15 32
Developmental Expressive Language Disorder 12 71

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11385
ICD9CM 34 315.31
NCIt 49 C92562
SNOMED-CT 67 80360005
ICD10 32 F80.1
UMLS 71 C0236826
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Summaries for Expressive Language Disorder

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Disease Ontology : 12 A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits.

MalaCards based summary : Expressive Language Disorder, also known as developmental expressive language disorder, is related to mixed receptive-expressive language disorder and articulation disorder. An important gene associated with Expressive Language Disorder is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor). Affiliated tissues include brain, heart and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Expressive language disorder is a communication disorder in which there are difficulties with verbal and... more...

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Related Diseases for Expressive Language Disorder

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Diseases related to Expressive Language Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 mixed receptive-expressive language disorder 33.3 TOR3A SLC6A8 CMIP ATP2C2
2 articulation disorder 29.7 FOXP2 CEBPD
3 speech and communication disorders 29.2 TOR3A FOXP2 CMIP CEBPD ATP2C2
4 dysphasia, familial developmental 10.6
5 developmental coordination disorder 10.1 CEBPD ATP2C2
6 myotonic disease 10.1 ERCC6 CEBPD
7 echolalia 10.0 TOR3A FOXP2 CEBPD
8 speech disorder 10.0 TOR3A FOXP2 CEBPD
9 deafness, autosomal recessive 14 10.0 IMMP2L DOCK4
10 deafness, autosomal recessive 17 9.9 IMMP2L DOCK4
11 specific developmental disorder 9.9 TOR3A FOXP2 ERCC6
12 deafness, autosomal dominant 2a 9.9 IMMP2L DOCK4
13 myotonic dystrophy 1 9.9 ERCC6 CEBPD
14 autism 9.8
15 apraxia 9.8
16 benign epilepsy with centrotemporal spikes 9.6 FOXP2 CMIP CEBPD ATP2C2
17 pervasive developmental disorder 9.5 TOR3A IMMP2L FOXP2 ERCC6 CEBPD
18 specific language impairment 9.4 TOR3A FOXP2 CMIP CEBPD ATP2C2
19 reading disorder 8.9 IMMP2L FOXP2 DOCK4 CMIP CEBPD ATP2C2
20 dyslexia 8.9 IMMP2L FOXP2 DOCK4 CMIP CEBPD ATP2C2
21 autism spectrum disorder 8.8 SLC6A8 IMMP2L FOXP2 CMIP

Comorbidity relations with Expressive Language Disorder via Phenotypic Disease Network (PDN):


Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation

Graphical network of the top 20 diseases related to Expressive Language Disorder:



Diseases related to Expressive Language Disorder
Sources

Symptoms & Phenotypes for Expressive Language Disorder

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GenomeRNAi Phenotypes related to Expressive Language Disorder according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 SLC6A8
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.83 ERCC6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.83 ERCC6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.83 ERCC6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.83 SLC6A8
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 ATF7IP2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.83 ATF7IP2 ERCC6 SLC6A8
8 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.83 ERCC6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.83 ERCC6 SLC6A8
10 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.83 ERCC6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.83 ERCC6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.83 ERCC6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.83 ATF7IP2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.83 ATF7IP2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.83 ERCC6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.83 ERCC6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.83 ERCC6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.83 ERCC6
19 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.83 ERCC6
20 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.83 ERCC6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.83 ATF7IP2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-44 9.83 ERCC6
23 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.83 ATF7IP2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.83 SLC6A8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.83 ATF7IP2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.83 SLC6A8
27 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.83 SLC6A8
28 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.83 ERCC6
29 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.83 SLC6A8
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Drugs & Therapeutics for Expressive Language Disorder

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Search Clinical Trials , NIH Clinical Center for Expressive Language Disorder

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Genetic Tests for Expressive Language Disorder

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Anatomical Context for Expressive Language Disorder

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MalaCards organs/tissues related to Expressive Language Disorder:

40
Brain, Heart, Testes
Sources

Publications for Expressive Language Disorder

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Articles related to Expressive Language Disorder:

(show all 48)
# Title Authors PMID Year
1
[Floating-Harbor syndrome: a case report and literature review]. 61
31874661 2019
2
Cognitive profile and disorders affecting higher brain functions in paediatric patients with neurofibromatosis type 1. 61
28431841 2019
3
Children screening positive for language delay at 2.5 years: language disorder and developmental profiles. 61
30568449 2018
4
Adaptation, validity, and reliability of the Preschool Language Scale-Fifth Edition (PLS-5) in the Turkish context: The Turkish Preschool Language Scale-5 (TPLS-5). 61
28583491 2017
5
FOXP2-Related Speech and Language Disorders 61
27336128 2016
6
Expanding the phenotypic profile of Kleefstra syndrome: A female with low-average intelligence and childhood apraxia of speech. 61
26833960 2016
7
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. 61
26777270 2016
8
Sensorimotor function in preschool-aged children with expressive language disorder. 61
24685939 2014
9
Health related quality of life in parents of children with speech and hearing impairment. 61
24388315 2014
10
Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria. 61
23918746 2013
11
[Abnormal electroencephalography results and specific language impairment: towards a theoretical neurodevelopmental model?]. 61
22980473 2012
12
The validity of psychiatric diagnoses: the case of 'specific' developmental disorders. 61
21705192 2011
13
Children with 7q11.23 Duplication Syndrome: Speech, Language, Cognitive, and Behavioral Characteristics and their Implications for Intervention. 61
22754604 2011
14
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene. 61
21424531 2011
15
Speech and language delay in children. 61
21568252 2011
16
Role of assessment tests in the stability of intelligence scoring of pre-school children with uneven/delayed cognitive profile. 61
21375639 2011
17
[Expressive language disorder and focal paroxysmal activity]. 61
21365595 2011
18
Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature. 61
21074868 2011
19
How to distinguish normal from disordered children with poor language or motor skills. 61
20144011 2010
20
Ian: a 7-year old with prenatal drug exposure and early exposure to family violence. 61
20414070 2010
21
Is expressive language disorder an accurate diagnostic category? 61
19029534 2009
22
A longitudinal study of personality disorders in individuals with and without a history of developmental language disorder. 61
19626542 2009
23
Children with mixed language disorder do not discriminate accurately facial identity when expressions change. 61
18427859 2008
24
Ian: a 7-year old with prenatal drug exposure and early exposure to family violence. 61
19077846 2008
25
A longitudinal study of schizophrenia- and affective spectrum disorders in individuals diagnosed with a developmental language disorder as children. 61
18818864 2008
26
Using a speech-generating device to enhance communicative abilities for an adult with moderate intellectual disability. 61
19090639 2008
27
Correlates of language impairment in children with galactosaemia. 61
18649009 2008
28
Can autism, language and coordination disorders be differentiated based on ability profiles? 61
17136301 2007
29
Epidemiological study of child & adolescent psychiatric disorders in urban & rural areas of Bangalore, India. 61
16106093 2005
30
[Specific language disorders: their diagnosis, classification and study using magnetoencephalography]. 61
15736073 2005
31
Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study. 61
15532707 2004
32
[Concerning specific language impairment: intelligibility in expressive language]. 61
15284946 2004
33
Comparative study of early childhood high-function autism and developmental mixed receptive-expressive language disorder. 61
15481561 2004
34
Co-morbidity and treatment of attention deficit hyperactivity disorder in Saudi Arabia. 61
16450529 2003
35
[Expressive language disorder]. 61
14503321 2003
36
Evaluation of neuromotor deficits in children with autism and children with a specific speech and language disorder. 61
12469239 2002
37
Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder. 61
12025433 2002
38
[Behavioral problems in children with specific and pervasive developmental disorders, evaluated with the psychopathology assessment scale (AMDP)]. 61
11721613 2001
39
Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder. 61
11642481 2001
40
Diagnostic assessment of communicative and interactive behaviours in children with autism and receptive language disorder. 61
11202105 2000
41
Expressive language disorder after infarction of left lentiform nucleus. 61
10942673 2000
42
The influence of premorbid language skills and behavior on language recovery in children with verbal auditory agnosia. 61
10641609 2000
43
Genetic studies of autistic disorder and chromosome 7. 61
10552924 1999
44
Evaluation and management of the child with speech delay. 61
10392594 1999
45
Subtyping stereotypic behavior in children: the association between stereotypic behavior, mood, and heart rate. 61
9932241 1998
46
The effect of a diagnostic label of language delay on adults' perceptions of preschool children. 61
8942302 1996
47
Behavioral correlates of developmental expressive language disorder. 61
2745899 1989
48
Language growth in children with expressive language delay. 61
2913552 1989
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Variations for Expressive Language Disorder

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Expression for Expressive Language Disorder

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Search GEO for disease gene expression data for Expressive Language Disorder.
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Pathways for Expressive Language Disorder

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GO Terms for Expressive Language Disorder

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Sources for Expressive Language Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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