MCID: EXT023
MIFTS: 24

External Ear Carcinoma

Categories: Cancer diseases, Ear diseases, Neuronal diseases

Aliases & Classifications for External Ear Carcinoma

MalaCards integrated aliases for External Ear Carcinoma:

Name: External Ear Carcinoma 12 15 70
Carcinoma of the External Ear 12
Carcinoma of External Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4288
NCIt 50 C6081
UMLS 70 C1333492

Summaries for External Ear Carcinoma

Disease Ontology : 12 An external ear cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

MalaCards based summary : External Ear Carcinoma, also known as carcinoma of the external ear, is related to adenoid cystic carcinoma and basal cell carcinoma. An important gene associated with External Ear Carcinoma is HPD (4-Hydroxyphenylpyruvate Dioxygenase). Affiliated tissues include breast, thyroid and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for External Ear Carcinoma

Diseases related to External Ear Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.1 PGR KRT7 KRT5
2 basal cell carcinoma 29.9 KRT7 KRT5 CEACAM5
3 malignant syringoma 29.6 KRT7 KRT5 CEACAM5
4 neuroendocrine carcinoma 29.4 KRT7 CEACAM5 CALCA
5 mucoepidermoid carcinoma 29.1 KRT7 KRT5 CEACAM5 CALCA
6 external ear basal cell carcinoma 11.3
7 external ear squamous cell carcinoma 11.3
8 renal pelvis squamous cell carcinoma 10.2 KRT5 CRP
9 ureter squamous cell carcinoma 10.2 KRT7 KRT5
10 inverted transitional papilloma 10.2 KRT7 KRT5
11 ceruminoma 10.2 KRT7 KRT5
12 subareolar duct papillomatosis 10.2 KRT7 KRT5
13 lipid-rich breast carcinoma 10.2 PGR KRT5
14 basaloid lung carcinoma 10.2 PGR KRT5
15 nipple benign neoplasm 10.2 KRT7 KRT5
16 auditory system benign neoplasm 10.2 KRT7 KRT5
17 microinvasive cervical squamous cell carcinoma 10.2 KRT7 KRT5
18 ceruminous adenocarcinoma 10.2 KRT7 KRT5
19 pregnancy adenoma 10.2 PGR KRT5
20 benign breast adenomyoepithelioma 10.2 KRT7 KRT5
21 lung clear cell carcinoma 10.2 KRT7 KRT5
22 heart cancer 10.2 KRT5 CRP
23 breast papillary carcinoma 10.2 PGR KRT5
24 necrotizing sialometaplasia 10.2 KRT7 KRT5
25 sensory organ benign neoplasm 10.2 KRT7 KRT5
26 gastric squamous cell carcinoma 10.2 KRT7 KRT5
27 breast myoepithelial carcinoma 10.2 PGR KRT5
28 middle ear adenocarcinoma 10.2 KRT7 KRT5
29 large cell acanthoma 10.2 KRT7 KRT5
30 balloon cell malignant melanoma 10.2 KRT7 KRT5
31 nephrogenic adenoma of the urethra 10.2 KRT7 KRT5
32 cystadenofibroma 10.2 KRT7 KRT5
33 trachea carcinoma 10.2 KRT7 KRT5
34 lipid-rich carcinoma 10.2 PGR KRT5
35 mucinous stomach adenocarcinoma 10.2 KRT7 KRT5
36 breast sarcoma 10.1 PGR KRT5
37 breast malignant phyllodes tumor 10.1 PGR KRT5
38 endobronchial lipoma 10.1 KRT7 KRT5
39 solid adenocarcinoma with mucin production 10.1 KRT7 KRT5
40 thymus clear cell carcinoma 10.1 KRT7 KRT5
41 liver leiomyosarcoma 10.1 KRT7 KRT5
42 middle ear carcinoma 10.1 KRT7 KRT5
43 gallbladder small cell carcinoma 10.1 KRT7 CRP
44 adenoid squamous cell carcinoma 10.1 KRT7 KRT5
45 epididymis adenocarcinoma 10.1 KRT7 KRT5
46 epididymis cancer 10.1 KRT7 KRT5
47 central epithelioid sarcoma 10.1 KRT7 KRT5
48 vulvar proximal-type epithelioid sarcoma 10.1 KRT7 KRT5
49 urethra clear cell adenocarcinoma 10.1 KRT7 KRT5
50 synchronous bilateral breast carcinoma 10.1 PGR KRT5

Graphical network of the top 20 diseases related to External Ear Carcinoma:



Diseases related to External Ear Carcinoma

Symptoms & Phenotypes for External Ear Carcinoma

GenomeRNAi Phenotypes related to External Ear Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.17 HPD
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.17 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.17 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT5 KRT7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.17 HPD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.17 HPD

Drugs & Therapeutics for External Ear Carcinoma

Search Clinical Trials , NIH Clinical Center for External Ear Carcinoma

Genetic Tests for External Ear Carcinoma

Anatomical Context for External Ear Carcinoma

MalaCards organs/tissues related to External Ear Carcinoma:

40
Breast, Thyroid, Liver, Lung, Thymus, Colon, Appendix

Publications for External Ear Carcinoma

Articles related to External Ear Carcinoma:

(show all 45)
# Title Authors PMID Year
1
Assessment of Masses of the External Ear With Diffusion-Weighted MR Imaging. 61
29227439 2018
2
Adenoid cystic carcinoma of the external ear: a population based study. 61
27040415 2016
3
Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear. 61
25182221 2015
4
[Bilateral bisphosphonate-associated osteonecrosis of the external ear canal : a rare case]. 61
23202871 2012
5
Metastatic cutaneous squamous cell carcinoma of the external ear: a high-risk cutaneous subsite. 61
19775493 2010
6
Benign necrotizing otitis externa. 61
19517392 2009
7
[Bilateral auditory canal squamous cell carcinoma]. 61
15711807 2006
8
A case of highly aggressive adenoid cystic carcinoma of the external auditory canal. 61
15952686 2004
9
Extended vertical trapezius myocutaneous flap in head and neck reconstruction as a salvage procedure. 61
15277797 2004
10
[Squamous cell carcinoma of the external ear. A carcinoma of old age which requires individualized therapy planning]. 61
15257397 2004
11
Microcystic adnexal carcinoma of the external ear canal. 61
14726925 2004
12
Squamous carcinoma of the external auditory canal: a different approach. 61
12071994 2002
13
Malignancies of the external auditory canal and temporal bone: a review. 61
12074062 2002
14
[Advanced squamous carcinoma of external ear canal]. 61
12596352 2002
15
[Carcinoma of the external ear canal and middle ear as interdisciplinary challenge for ear surgery and radiotherapy]. 61
11383121 2001
16
Squamous cell carcinoma of the temporal bone: diagnosis, treatment and prognosis. 61
11193117 2000
17
[Carcinoma of the temporal bone--current diagnostic and therapeutic aspects]. 61
8561818 1995
18
Anthelix-conchal reconstruction with postauricular "revolving door" island flap. 61
8627097 1995
19
[Cystic adenoidal carcinoma of the external ear]. 61
8086202 1994
20
Surgical management of benign necrotizing otitis externa. 61
8163907 1994
21
[Cutaneous neuroendocrine carcinoma of the external ear canal]. 61
7825937 1994
22
Pectoralis major myocutaneous flap for reconstruction of defects following resections in head and neck area. 61
8230657 1993
23
Localized carcinoma of the external ear is an unrecognized aggressive disease with a high propensity for local regional recurrence. 61
1463102 1992
24
Temporal bone resections for carcinoma of the middle ear and the external ear canal. 61
1463116 1992
25
[Primary neuroendocrine carcinoma of the pavilion of the ear]. 61
1790063 1991
26
[Photodynamic laser tumor therapy with a hematoporphyrin derivative in spinocellular carcinoma of the external ear]. 61
2818783 1989
27
Micrographic surgery for the microscopically controlled excision of carcinoma of the external ear. 61
3053805 1988
28
Squamous cell carcinoma of the external ear: a review of 75 cases. 61
3118313 1987
29
[Lower trapezius musculocutaneous flap for the repair of neoplastic loss of substance of the ear]. 61
6391337 1984
30
Squamous carcinoma of the external ear. 61
6625089 1983
31
Guidelines for prophylactic radical lymph node dissection in cases of carcinoma of the external ear. 61
7364589 1980
32
[2 cases of adenoid cystic carcinoma of the external ear]. 61
227330 1977
33
Carcinoma of the external ear. 61
1019587 1976
34
[Carcinoma of the external ear]. 61
1118177 1975
35
Carcinoma of the external ear. 61
4797684 1973
36
Basal cell carcinoma of the external ear in an 18-year-old male. 61
4933227 1971
37
[On the surgical technic of external ear carcinoma]. 61
5672035 1968
38
Carcinoma of the external ear. A guide to surgical management. 61
6075051 1967
39
CHEMOSURGICAL MANAGEMENT OF CARCINOMA OF THE EXTERNAL EAR. 61
14048021 1963
40
Transitional cell type squamous cell carcinoma of the external ear canal. 61
13612253 1958
41
[Resuls of contact irradiation of carcinoma of the external ear]. 61
13562697 1958
42
Carcinoma of the external ear; analysis of 100 consecutive cases. 61
13484496 1957
43
[Complete healing of external ear carcinoma with combined therapy of placental extract and Bogomoletz serum]. 61
13360776 1956
44
Carcinoma of the External Ear. 61
19989082 1933
45
Carcinoma of the External Ear. 61
19977167 1913

Variations for External Ear Carcinoma

Expression for External Ear Carcinoma

Search GEO for disease gene expression data for External Ear Carcinoma.

Pathways for External Ear Carcinoma

GO Terms for External Ear Carcinoma

Sources for External Ear Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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