MCID: EXT056
MIFTS: 32

External Ear Disease

Categories: Ear diseases

Aliases & Classifications for External Ear Disease

MalaCards integrated aliases for External Ear Disease:

Name: External Ear Disease 12 15
Preauricular Cyst 12 73
Preauricular Sinus and Fistula 12
Preauricular Sinus or Fistula 12
Diseases of External Ear 73

Classifications:



Summaries for External Ear Disease

MalaCards based summary : External Ear Disease, also known as preauricular cyst, is related to otitis externa and acute dacryocystitis. An important gene associated with External Ear Disease is CALM3 (Calmodulin 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and TCR Signaling (Qiagen). Related phenotype is Reduced mammosphere formation.

Related Diseases for External Ear Disease

Graphical network of the top 20 diseases related to External Ear Disease:



Diseases related to External Ear Disease

Symptoms & Phenotypes for External Ear Disease

GenomeRNAi Phenotypes related to External Ear Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 CALM1 CALM2 CALM3 POLB

Drugs & Therapeutics for External Ear Disease

Search Clinical Trials , NIH Clinical Center for External Ear Disease

Genetic Tests for External Ear Disease

Anatomical Context for External Ear Disease

Publications for External Ear Disease

Articles related to External Ear Disease:

# Title Authors Year
1
Primary Cutaneous Coccidioidomycosis Presenting as a Recurrent Preauricular Cyst. ( 27319963 )
2016
2
Preauricular cyst associated with congenital cholesteatoma: an unusual cause of facial palsy. ( 8172317 )
1994

Variations for External Ear Disease

Expression for External Ear Disease

Search GEO for disease gene expression data for External Ear Disease.

Pathways for External Ear Disease

Pathways related to External Ear Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CALM1 CALM2 CALM3 DOCK8
2
Show member pathways
12.78 CALM1 CALM2 CALM3 POLB
3
Show member pathways
12.59 CALM1 CALM2 CALM3
4
Show member pathways
12.58 CALM1 CALM2 CALM3
5
Show member pathways
12.58 CALM1 CALM2 CALM3
6
Show member pathways
12.57 CALM1 CALM2 CALM3
7
Show member pathways
12.56 CALM1 CALM2 CALM3
8
Show member pathways
12.53 CALM1 CALM2 CALM3
9
Show member pathways
12.52 CALM1 CALM2 CALM3
10
Show member pathways
12.52 CALM1 CALM2 CALM3
11
Show member pathways
12.51 CALM1 CALM2 CALM3
12
Show member pathways
12.47 CALM1 CALM2 CALM3
13
Show member pathways
12.46 CALM1 CALM2 CALM3
14
Show member pathways
12.45 CALM1 CALM2 CALM3
15
Show member pathways
12.45 CALM1 CALM2 CALM3
16
Show member pathways
12.43 CALM1 CALM2 CALM3
17
Show member pathways
12.42 CALM1 CALM2 CALM3
18
Show member pathways
12.41 CALM1 CALM2 CALM3
19
Show member pathways
12.4 CALM1 CALM2 CALM3
20
Show member pathways
12.38 CALM1 CALM2 CALM3
21
Show member pathways
12.33 CALM1 CALM2 CALM3
22
Show member pathways
12.32 CALM1 CALM2 CALM3
23
Show member pathways
12.31 CALM1 CALM2 CALM3
24
Show member pathways
12.31 CALM1 CALM2 CALM3
25
Show member pathways
12.29 CALM1 CALM2 CALM3
26
Show member pathways
12.28 CALM1 CALM2 CALM3
27
Show member pathways
12.27 CALM1 CALM2 CALM3
28 12.26 CALM1 CALM2 CALM3
29
Show member pathways
12.25 CALM1 CALM2 CALM3
30
Show member pathways
12.24 CALM1 CALM2 CALM3
31
Show member pathways
12.22 CALM1 CALM2 CALM3
32
Show member pathways
12.22 CALM1 CALM2 CALM3
33
Show member pathways
12.21 CALM1 CALM2 CALM3
34
Show member pathways
12.19 CALM1 CALM2 CALM3
35
Show member pathways
12.16 CALM1 CALM2 CALM3
36
Show member pathways
12.16 CALM1 CALM2 CALM3
37
Show member pathways
12.15 CALM1 CALM2 CALM3
38
Show member pathways
12.14 CALM1 CALM2 CALM3
39 12.12 CALM1 CALM2 CALM3
40
Show member pathways
12.1 CALM1 CALM2 CALM3
41
Show member pathways
12.1 CALM1 CALM2 CALM3
42
Show member pathways
12.08 CALM1 CALM2 CALM3
43
Show member pathways
12.07 CALM1 CALM2 CALM3
44
Show member pathways
12.06 CALM1 CALM2 CALM3
45 12.05 CALM1 CALM2 CALM3
46
Show member pathways
12.04 CALM1 CALM2 CALM3
47
Show member pathways
12.02 CALM1 CALM2 CALM3
48 11.98 CALM1 CALM2 CALM3
49 11.98 CALM1 CALM2 CALM3
50
Show member pathways
11.94 CALM1 CALM2 CALM3

GO Terms for External Ear Disease

Cellular components related to External Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.67 CALM1 CALM2 CALM3 POLB
2 spindle GO:0005819 9.61 CALM1 CALM2 CALM3
3 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
5 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.33 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 9.13 CALM1 CALM2 CALM3
8 spindle microtubule GO:0005876 8.92 CALM1 CALM2 CALM3 POLB

Biological processes related to External Ear Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
2 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
3 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
4 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
7 positive regulation of protein autophosphorylation GO:0031954 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
12 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.63 CALM1 CALM2 CALM3
13 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
14 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.58 CALM1 CALM2 CALM3
15 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
16 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
17 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
18 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
19 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
20 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to External Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.65 CALM1 CALM2 CALM3
2 protein domain specific binding GO:0019904 9.63 CALM1 CALM2 CALM3
3 ion channel binding GO:0044325 9.58 CALM1 CALM2 CALM3
4 disordered domain specific binding GO:0097718 9.54 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.5 CALM1 CALM2 CALM3
6 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
7 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
8 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
9 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for External Ear Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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