MCID: EXT056
MIFTS: 32

External Ear Disease

Categories: Ear diseases

Aliases & Classifications for External Ear Disease

MalaCards integrated aliases for External Ear Disease:

Name: External Ear Disease 12 15
Preauricular Cyst 12 73
Preauricular Sinus and Fistula 12
Preauricular Sinus or Fistula 12
Diseases of External Ear 73

Classifications:



External Ids:

Disease Ontology 12 DOID:379
ICD9CM 35 380 380.9
NCIt 50 C26972
SNOMED-CT 68 49130001

Summaries for External Ear Disease

MalaCards based summary : External Ear Disease, also known as preauricular cyst, is related to otitis externa and long qt syndrome 15. An important gene associated with External Ear Disease is CALM3 (Calmodulin 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Circadian entrainment.

Related Diseases for External Ear Disease

Diseases related to External Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 otitis externa 30.3 CALM1 CALM2 CALM3 DOCK8 EARS2 MTFMT
2 long qt syndrome 15 10.0 CALM1 CALM2 CALM3
3 long qt syndrome 1 10.0 CALM1 CALM2 CALM3
4 long qt syndrome 10.0 CALM1 CALM2 CALM3
5 otomycosis 10.0 CALM1 CALM2 CALM3
6 emery-dreifuss muscular dystrophy 5, autosomal dominant 10.0 CALM1 CALM2 CALM3
7 sporotrichosis 10.0 CALM1 CALM2 CALM3
8 spontaneous ocular nystagmus 10.0 CALM1 CALM2 CALM3
9 deafness, autosomal recessive 44 9.9 CALM1 CALM2 CALM3
10 acute dacryocystitis 9.9 CALM1 CALM2 CALM3
11 dystonia 24 9.9 CALM1 CALM2 CALM3
12 gestational choriocarcinoma 9.9 CALM1 CALM2 CALM3
13 triosephosphate isomerase deficiency 9.9 CALM1 CALM2 CALM3
14 leber congenital amaurosis 2 9.9 CALM1 CALM2 CALM3
15 tinea unguium 9.9 CALM1 CALM2 CALM3
16 coccidioidomycosis 9.9
17 primary systemic mycosis 9.9 CALM1 CALM2 CALM3
18 clear cell acanthoma 9.9 CALM1 CALM2 CALM3
19 cardiomyopathy, dilated, 1a 9.9 CALM1 CALM2 CALM3
20 cardiomyopathy, dilated, 1p 9.9 CALM1 CALM2 CALM3
21 phaeohyphomycosis 9.9 CALM1 CALM2 CALM3
22 deafness, autosomal dominant 2a 9.9 CALM1 CALM2 CALM3
23 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 9.9 CALM1 CALM2 CALM3
24 ceroid lipofuscinosis, neuronal, 11 9.8 CALM1 CALM2 CALM3
25 auditory system disease 9.8
26 catecholaminergic polymorphic ventricular tachycardia 9.8 CALM1 CALM2 CALM3
27 primary cutaneous amyloidosis 9.8 CALM1 CALM2 CALM3 KRT16
28 cardiac arrest 9.7 CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to External Ear Disease:



Diseases related to External Ear Disease

Symptoms & Phenotypes for External Ear Disease

Drugs & Therapeutics for External Ear Disease

Search Clinical Trials , NIH Clinical Center for External Ear Disease

Genetic Tests for External Ear Disease

Anatomical Context for External Ear Disease

Publications for External Ear Disease

Articles related to External Ear Disease:

# Title Authors Year
1
Primary Cutaneous Coccidioidomycosis Presenting as a Recurrent Preauricular Cyst. ( 27319963 )
2016
2
Preauricular cyst associated with congenital cholesteatoma: an unusual cause of facial palsy. ( 8172317 )
1994

Variations for External Ear Disease

Expression for External Ear Disease

Search GEO for disease gene expression data for External Ear Disease.

Pathways for External Ear Disease

Pathways related to External Ear Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CALM1 CALM2 CALM3 DOCK8
2
Show member pathways
12.9 CALM1 CALM2 CALM3 KRT16
3
Show member pathways
12.67 CALM1 CALM2 CALM3
4
Show member pathways
12.59 CALM1 CALM2 CALM3
5
Show member pathways
12.59 CALM1 CALM2 CALM3
6
Show member pathways
12.59 CALM1 CALM2 CALM3
7
Show member pathways
12.58 CALM1 CALM2 CALM3
8
Show member pathways
12.56 CALM1 CALM2 CALM3
9
Show member pathways
12.54 CALM1 CALM2 CALM3
10
Show member pathways
12.53 CALM1 CALM2 CALM3
11
Show member pathways
12.53 CALM1 CALM2 CALM3
12
Show member pathways
12.52 CALM1 CALM2 CALM3
13
Show member pathways
12.5 CALM1 CALM2 CALM3
14
Show member pathways
12.48 CALM1 CALM2 CALM3
15
Show member pathways
12.47 CALM1 CALM2 CALM3
16
Show member pathways
12.45 CALM1 CALM2 CALM3
17
Show member pathways
12.43 CALM1 CALM2 CALM3
18
Show member pathways
12.43 CALM1 CALM2 CALM3
19
Show member pathways
12.42 CALM1 CALM2 CALM3
20
Show member pathways
12.4 CALM1 CALM2 CALM3
21
Show member pathways
12.39 CALM1 CALM2 CALM3
22
Show member pathways
12.34 CALM1 CALM2 CALM3
23
Show member pathways
12.33 CALM1 CALM2 CALM3
24
Show member pathways
12.32 CALM1 CALM2 CALM3
25
Show member pathways
12.31 CALM1 CALM2 CALM3
26
Show member pathways
12.31 CALM1 CALM2 CALM3
27
Show member pathways
12.3 CALM1 CALM2 CALM3
28
Show member pathways
12.29 CALM1 CALM2 CALM3
29
Show member pathways
12.28 CALM1 CALM2 CALM3
30 12.26 CALM1 CALM2 CALM3
31
Show member pathways
12.25 CALM1 CALM2 CALM3
32
Show member pathways
12.24 CALM1 CALM2 CALM3
33
Show member pathways
12.23 CALM1 CALM2 CALM3
34
Show member pathways
12.22 CALM1 CALM2 CALM3
35
Show member pathways
12.22 CALM1 CALM2 CALM3
36
Show member pathways
12.21 CALM1 CALM2 CALM3
37
Show member pathways
12.2 CALM1 CALM2 CALM3
38
Show member pathways
12.16 CALM1 CALM2 CALM3
39
Show member pathways
12.16 CALM1 CALM2 CALM3
40
Show member pathways
12.14 CALM1 CALM2 CALM3
41 12.13 CALM1 CALM2 CALM3
42
Show member pathways
12.11 CALM1 CALM2 CALM3
43
Show member pathways
12.11 CALM1 CALM2 CALM3
44
Show member pathways
12.09 CALM1 CALM2 CALM3
45
Show member pathways
12.08 CALM1 CALM2 CALM3
46
Show member pathways
12.06 CALM1 CALM2 CALM3
47 12.06 CALM1 CALM2 CALM3
48
Show member pathways
12.05 CALM1 CALM2 CALM3
49
Show member pathways
12.03 CALM1 CALM2 CALM3
50 11.99 CALM1 CALM2 CALM3

GO Terms for External Ear Disease

Cellular components related to External Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.61 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
3 myelin sheath GO:0043209 9.54 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
5 synaptic vesicle membrane GO:0030672 9.46 CALM1 CALM3
6 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
7 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
8 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
9 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to External Ear Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.77 CALM1 CALM2 CALM3
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
5 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
6 regulation of heart rate GO:0002027 9.72 CALM1 CALM2 CALM3
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 positive regulation of protein autophosphorylation GO:0031954 9.69 CALM1 CALM2 CALM3
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
11 regulation of synaptic vesicle exocytosis GO:2000300 9.65 CALM1 CALM3
12 response to amphetamine GO:0001975 9.65 CALM1 CALM3
13 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
14 activation of adenylate cyclase activity GO:0007190 9.64 CALM1 CALM3
15 positive regulation of DNA binding GO:0043388 9.64 CALM2 CALM3
16 positive regulation of nitric-oxide synthase activity GO:0051000 9.63 CALM1 CALM3
17 response to corticosterone GO:0051412 9.63 CALM1 CALM3
18 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
19 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.62 CALM1 CALM3
20 regulation of synaptic vesicle endocytosis GO:1900242 9.62 CALM1 CALM3
21 establishment of protein localization to membrane GO:0090150 9.61 CALM1 CALM3
22 regulation of high voltage-gated calcium channel activity GO:1901841 9.61 CALM1 CALM3
23 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
24 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
25 establishment of protein localization to mitochondrial membrane GO:0090151 9.56 CALM1 CALM3
26 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
27 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
28 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
29 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
30 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
31 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to External Ear Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.72 CALM1 CALM2 CALM3
2 ion channel binding GO:0044325 9.65 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.58 CALM1 CALM2 CALM3
4 calcium-dependent protein binding GO:0048306 9.56 CALM1 CALM3
5 enzyme regulator activity GO:0030234 9.54 CALM1 CALM3
6 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
7 phosphatidylinositol 3-kinase binding GO:0043548 9.52 CALM1 CALM3
8 nitric-oxide synthase binding GO:0050998 9.51 CALM1 CALM3
9 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
10 calcium channel inhibitor activity GO:0019855 9.49 CALM1 CALM2
11 nitric-oxide synthase regulator activity GO:0030235 9.46 CALM1 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.43 CALM1 CALM3
13 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
14 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
15 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
16 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for External Ear Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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