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MCID: EXT020
MIFTS: 25

External Pathological Resorption

Categories: Oral diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for External Pathological Resorption

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MalaCards integrated aliases for External Pathological Resorption:

Name: External Pathological Resorption 12 15
External Resorption of Tooth 71

Classifications:

MalaCards categories:
Anatomical: Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14529
ICD9CM 34 521.42
SNOMED-CT 67 41918006 43079004
ICD10 32 K03.3
UMLS 71 C0266878
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Summaries for External Pathological Resorption

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MalaCards based summary : External Pathological Resorption, also known as external resorption of tooth, is related to scorpion envenomation and idiopathic anterior uveitis. An important gene associated with External Pathological Resorption is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and IL-17 Family Signaling Pathways. Affiliated tissues include bone, heart and liver.

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Related Diseases for External Pathological Resorption

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Diseases in the Internal Pathological Resorption family:

External Pathological Resorption

Diseases related to External Pathological Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
# Related Disease Score Top Affiliating Genes
1 scorpion envenomation 10.0 TNF IL6
2 idiopathic anterior uveitis 9.9 TNF IL6
3 uveitis 9.9 TNF IL6
4 streptococcal toxic-shock syndrome 9.9 TNF IL6
5 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 TNF IL6
6 null-cell leukemia 9.9 TNF IL6
7 non-alcoholic steatohepatitis 9.9 TNF IL6
8 posterior urethral valves 9.9 TNF IL6
9 stachybotrys chartarum 9.9 TNF IL6
10 post-transplant lymphoproliferative disease 9.9 TNF IL6
11 aortitis 9.9 TNF IL6
12 retinitis pigmentosa 55 9.9 TNF IL6
13 transverse myelitis 9.9 TNF IL6
14 myelitis 9.9 TNF IL6
15 eales disease 9.9 TNF IL6
16 tenosynovitis 9.9 TNF IL6
17 synovitis 9.9 TNF IL6
18 anthracosis 9.9 TNF IL6
19 pneumonic tularemia 9.9 TNF IL6
20 tularemia 9.9 TNF IL6
21 scleral disease 9.9 TNF IL6
22 lung abscess 9.9 TNF IL6
23 autoimmune disease of cardiovascular system 9.9 TNF IL6
24 chlamydia pneumonia 9.9 TNF IL6
25 chlamydia 9.9 TNF IL6
26 irritant dermatitis 9.9 TNF IL6
27 dermatitis 9.9 TNF IL6
28 iritis 9.9 TNF IL6
29 idiopathic neutropenia 9.9 TNF IL6
30 chorioretinitis 9.9 TNF IL6
31 iridocyclitis 9.9 TNF IL6
32 periapical periodontitis 9.9 TNF IL6
33 periodontitis 9.9 TNF IL6
34 dental pulp disease 9.9 TNF IL6
35 laryngitis 9.9 TNF IL6
36 bagassosis 9.9 TNF IL6
37 fungal meningitis 9.9 TNF IL6
38 meningitis 9.9 TNF IL6
39 trichomoniasis 9.9 TNF IL6
40 african tick-bite fever 9.9 TNF IL6
41 central nervous system vasculitis 9.9 TNF IL6
42 vasculitis 9.9 TNF IL6
43 orchitis 9.9 TNF IL6
44 chronic conjunctivitis 9.9 TNF IL6
45 conjunctivitis 9.9 TNF IL6
46 glossitis 9.9 TNF IL6
47 hantavirus hemorrhagic fever with renal syndrome 9.9 TNF IL6
48 tendinitis 9.9 TNF IL6
49 polyradiculopathy 9.9 TNF IL6
50 urethritis 9.9 TNF IL6

Graphical network of the top 20 diseases related to External Pathological Resorption:



Diseases related to External Pathological Resorption
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Symptoms & Phenotypes for External Pathological Resorption

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Drugs & Therapeutics for External Pathological Resorption

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Search Clinical Trials , NIH Clinical Center for External Pathological Resorption

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Genetic Tests for External Pathological Resorption

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Anatomical Context for External Pathological Resorption

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MalaCards organs/tissues related to External Pathological Resorption:

40
Bone, Heart, Liver, Thyroid, Eye, Spinal Cord, Lung
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Publications for External Pathological Resorption

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Articles related to External Pathological Resorption:

# Title Authors PMID Year
1
Trial shows partial caries removal is an effective technique in primary molars. 61
25343394 2014
2
Dental pulp and periodontal ligament cells support osteoclastic differentiation. 61
19641147 2009
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Variations for External Pathological Resorption

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Expression for External Pathological Resorption

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Search GEO for disease gene expression data for External Pathological Resorption.
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Pathways for External Pathological Resorption

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Pathways related to External Pathological Resorption according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Human T-cell leukemia virus 1 infection 36
12.04 TNF IL6
2
IL-17 Family Signaling Pathways 64
Show member pathways
 12.03 TNF IL6
3
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.02 TNF IL6
4
Folate Metabolism 1
Show member pathways
 12.02 TNF IL6
5
Pathogenic Escherichia coli infection 36
11.99 TNF IL6
6
Diseases associated with the TLR signaling cascade 65
Show member pathways
 11.96 TNF IL6
7
Dilated cardiomyopathy (DCM) 36
Show member pathways
 11.95 TNF IL6
8
NOD-like receptor signaling pathway 36
11.93 TNF IL6
9
Tuberculosis 36
11.93 TNF IL6
10
IL-1 Family Signaling Pathways 64
Show member pathways
 11.91 TNF IL6
11
C-type lectin receptor signaling pathway 36
Show member pathways
 11.9 TNF IL6
12
Colorectal Cancer Metastasis 63
11.88 TNF IL6
13
Bacterial infections in CF airways 22
Show member pathways
 11.88 TNF IL6
14
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.86 TNF IL6
15
Adipogenesis 1
11.77 TNF IL6
16
Th1 Differentiation Pathway 64
Show member pathways
 11.76 TNF IL6
17
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.74 TNF IL6
18
Yersinia infection 36
11.72 TNF IL6
19
Spinal Cord Injury 1
11.71 TNF IL6
20
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.69 TNF IL6
21
Interleukin-4 and 13 signaling 65
11.68 TNF IL6
22
TNF signaling pathway 36
11.67 TNF IL6
23
Insulin resistance 36
Show member pathways
 11.65 TNF IL6
24
Amoebiasis 36
11.61 TNF IL6
25
AGE-RAGE signaling pathway in diabetic complications 36
11.6 TNF IL6
26
Hematopoietic cell lineage 36
11.59 TNF IL6
27
Rheumatoid arthritis 36
11.55 TNF IL6
28
Pertussis 36
11.46 TNF IL6
29
Dendritic Cells Developmental Lineage Pathway 64
11.44 TNF IL6
30
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.41 TNF IL6
31
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.35 TNF IL6
32
Lung fibrosis 1
11.34 TNF IL6
33
Legionellosis 36
11.28 TNF IL6
34
Photodynamic therapy-induced AP-1 survival signaling. 1
11.22 TNF IL6
35
Malaria 36
11.19 TNF IL6
36
Interleukin-10 signaling 65
11.17 TNF IL6
37
amb2 Integrin signaling 1
11.14 TNF IL6
38
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.09 TNF IL6
39
African trypanosomiasis 36
10.97 TNF IL6
40
IL-10 Pathway 63
10.91 TNF IL6
41
Development and heterogeneity of the ILC family 1
10.83 TNF IL6
42
Antifolate resistance 36
10.75 TNF IL6
43
Cytokines and Inflammatory Response 1
10.62 TNF IL6
44
Transcription factor regulation in adipogenesis 1
10.3 TNF IL6
45
Overview of nanoparticle effects 1
9.9 TNF IL6
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GO Terms for External Pathological Resorption

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Biological processes related to External Pathological Resorption according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.57 TNF IL6
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 TNF IL6
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.55 TNF IL6
4 defense response to Gram-positive bacterium GO:0050830 9.54 TNF IL6
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.52 TNF IL6
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.51 TNF IL6
7 response to glucocorticoid GO:0051384 9.49 TNF IL6
8 positive regulation of interleukin-6 production GO:0032755 9.48 TNF IL6
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 TNF IL6
10 humoral immune response GO:0006959 9.43 TNF IL6
11 negative regulation of fat cell differentiation GO:0045599 9.4 TNF IL6
12 positive regulation of JAK-STAT cascade GO:0046427 9.37 TNF IL6
13 negative regulation of neurogenesis GO:0050768 9.32 TNF IL6
14 positive regulation of chemokine production GO:0032722 9.26 TNF IL6
15 positive regulation of glial cell proliferation GO:0060252 9.16 TNF IL6
16 positive regulation of neuroinflammatory response GO:0150078 8.96 TNF IL6
17 negative regulation of lipid storage GO:0010888 8.62 TNF IL6

Molecular functions related to External Pathological Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.62 TNF IL6
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Sources for External Pathological Resorption

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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