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MCID: EXT020
MIFTS: 23

External Pathological Resorption

Categories: Oral diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for External Pathological Resorption

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MalaCards integrated aliases for External Pathological Resorption:

Name: External Pathological Resorption 12 15
External Resorption of Tooth 71

Classifications:

MalaCards categories:
Anatomical: Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14529
ICD9CM 34 521.42
SNOMED-CT 67 41918006
ICD10 32 K03.3
UMLS 71 C0266878
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Summaries for External Pathological Resorption

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MalaCards based summary : External Pathological Resorption, also known as external resorption of tooth, is related to scorpion envenomation and idiopathic anterior uveitis. An important gene associated with External Pathological Resorption is IL6 (Interleukin 6), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and IL-17 Family Signaling Pathways. Affiliated tissues include salivary gland.

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Related Diseases for External Pathological Resorption

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Diseases in the Internal Pathological Resorption family:

External Pathological Resorption

Diseases related to External Pathological Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 436)
# Related Disease Score Top Affiliating Genes
1 scorpion envenomation 9.9 TNF IL6
2 idiopathic anterior uveitis 9.9 TNF IL6
3 uveitis 9.9 TNF IL6
4 streptococcal toxic-shock syndrome 9.9 TNF IL6
5 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 TNF IL6
6 null-cell leukemia 9.9 TNF IL6
7 anaerobic pneumonia 9.9 TNF IL6
8 posterior urethral valves 9.9 TNF IL6
9 stachybotrys chartarum 9.9 TNF IL6
10 post-transplant lymphoproliferative disease 9.9 TNF IL6
11 post-cardiac arrest syndrome 9.9 TNF IL6
12 transverse myelitis 9.9 TNF IL6
13 myelitis 9.9 TNF IL6
14 eales disease 9.9 TNF IL6
15 tracheitis 9.9 TNF IL6
16 carbuncle 9.9 TNF IL6
17 chemical colitis 9.9 TNF IL6
18 colitis 9.9 TNF IL6
19 heart aneurysm 9.9 TNF IL6
20 aortitis 9.9 TNF IL6
21 coronary aneurysm 9.9 TNF IL6
22 hypopyon 9.9 TNF IL6
23 tenosynovitis 9.9 TNF IL6
24 synovitis 9.9 TNF IL6
25 chondromalacia 9.9 TNF IL6
26 pneumonic tularemia 9.9 TNF IL6
27 blastomycosis 9.9 TNF IL6
28 retinitis pigmentosa 55 9.9 TNF IL6
29 scleral disease 9.9 TNF IL6
30 progressive myoclonus epilepsy 8 9.9 TNF IL6
31 lung abscess 9.9 TNF IL6
32 chlamydia pneumonia 9.9 TNF IL6
33 chlamydia 9.9 TNF IL6
34 peptic esophagitis 9.9 TNF IL6
35 esophagitis 9.9 TNF IL6
36 idiopathic neutropenia 9.9 TNF IL6
37 irritant dermatitis 9.9 TNF IL6
38 dermatitis 9.9 TNF IL6
39 iritis 9.9 TNF IL6
40 background diabetic retinopathy 9.9 TNF IL6
41 iridocyclitis 9.9 TNF IL6
42 chorioretinitis 9.9 TNF IL6
43 periapical periodontitis 9.9 TNF IL6
44 periodontitis 9.9 TNF IL6
45 laryngitis 9.9 TNF IL6
46 african tick-bite fever 9.9 TNF IL6
47 dental pulp disease 9.9 TNF IL6
48 neurotic disorder 9.9 TNF IL6
49 epididymis disease 9.9 TNF IL6
50 cardiomyopathy, familial hypertrophic, 20 9.9 TNF IL6

Graphical network of the top 20 diseases related to External Pathological Resorption:



Diseases related to External Pathological Resorption
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Symptoms & Phenotypes for External Pathological Resorption

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Drugs & Therapeutics for External Pathological Resorption

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Search Clinical Trials , NIH Clinical Center for External Pathological Resorption

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Genetic Tests for External Pathological Resorption

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Anatomical Context for External Pathological Resorption

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MalaCards organs/tissues related to External Pathological Resorption:

40
Salivary Gland
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Publications for External Pathological Resorption

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Articles related to External Pathological Resorption:

# Title Authors PMID Year
1
Trial shows partial caries removal is an effective technique in primary molars. 61
25343394 2014
2
Dental pulp and periodontal ligament cells support osteoclastic differentiation. 61
19641147 2009
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Variations for External Pathological Resorption

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Expression for External Pathological Resorption

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Search GEO for disease gene expression data for External Pathological Resorption.
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Pathways for External Pathological Resorption

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Pathways related to External Pathological Resorption according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Human T-cell leukemia virus 1 infection 36
12.03 TNF IL6
2
IL-17 Family Signaling Pathways 64
Show member pathways
 12.02 TNF IL6
3
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.02 TNF IL6
4
Folate Metabolism 1
Show member pathways
 12.01 TNF IL6
5
Salmonella infection (KEGG) 36
11.99 TNF IL6
6
Pathogenic Escherichia coli infection 36
11.96 TNF IL6
7
Diseases associated with the TLR signaling cascade 65
Show member pathways
 11.95 TNF IL6
8
Dilated cardiomyopathy (DCM) 36
Show member pathways
 11.94 TNF IL6
9
NOD-like receptor signaling pathway 36
11.92 TNF IL6
10
Tuberculosis 36
11.92 TNF IL6
11
C-type lectin receptor signaling pathway 36
Show member pathways
 11.9 TNF IL6
12
Colorectal Cancer Metastasis 63
11.87 TNF IL6
13
Bacterial infections in CF airways 22
Show member pathways
 11.87 TNF IL6
14
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.86 TNF IL6
15
Adipogenesis 1
11.76 TNF IL6
16
Yersinia infection 36
11.72 TNF IL6
17
Spinal Cord Injury 1
11.71 TNF IL6
18
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.69 TNF IL6
19
Interleukin-4 and 13 signaling 65
11.68 TNF IL6
20
TNF signaling pathway 36
11.67 TNF IL6
21
Insulin resistance 36
Show member pathways
 11.65 TNF IL6
22
IL27-mediated signaling events 1
Show member pathways
 11.63 TNF IL6
23
Amoebiasis 36
11.61 TNF IL6
24
AGE-RAGE signaling pathway in diabetic complications 36
11.59 TNF IL6
25
Hematopoietic cell lineage 36
11.58 TNF IL6
26
Rheumatoid arthritis 36
11.54 TNF IL6
27
Pertussis 36
11.45 TNF IL6
28
Dendritic Cells Developmental Lineage Pathway 64
11.43 TNF IL6
29
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.35 TNF IL6
30
Lung fibrosis 1
11.34 TNF IL6
31
Legionellosis 36
11.28 TNF IL6
32
Photodynamic therapy-induced AP-1 survival signaling. 1
11.22 TNF IL6
33
Malaria 36
11.19 TNF IL6
34
Interleukin-10 signaling 65
11.17 TNF IL6
35
amb2 Integrin signaling 1
11.14 TNF IL6
36
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.09 TNF IL6
37
African trypanosomiasis 36
10.97 TNF IL6
38
IL-10 Pathway 63
10.91 TNF IL6
39
Development and heterogeneity of the ILC family 1
10.83 TNF IL6
40
Antifolate resistance 36
10.75 TNF IL6
41
Cytokines and Inflammatory Response 1
10.62 TNF IL6
42
Transcription factor regulation in adipogenesis 1
10.3 TNF IL6
43
Overview of nanoparticle effects 1
9.9 TNF IL6
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GO Terms for External Pathological Resorption

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Biological processes related to External Pathological Resorption according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.58 TNF IL6
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 TNF IL6
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.57 TNF IL6
4 defense response to Gram-positive bacterium GO:0050830 9.56 TNF IL6
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.55 TNF IL6
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 TNF IL6
7 response to glucocorticoid GO:0051384 9.52 TNF IL6
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.51 TNF IL6
9 humoral immune response GO:0006959 9.49 TNF IL6
10 positive regulation of interleukin-6 production GO:0032755 9.48 TNF IL6
11 negative regulation of fat cell differentiation GO:0045599 9.46 TNF IL6
12 positive regulation of JAK-STAT cascade GO:0046427 9.43 TNF IL6
13 negative regulation of neurogenesis GO:0050768 9.4 TNF IL6
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.37 TNF IL6
15 positive regulation of chemokine production GO:0032722 9.32 TNF IL6
16 positive regulation of glial cell proliferation GO:0060252 9.26 TNF IL6
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.16 TNF IL6
18 positive regulation of neuroinflammatory response GO:0150078 8.96 TNF IL6
19 negative regulation of lipid storage GO:0010888 8.62 TNF IL6
Sources

Sources for External Pathological Resorption

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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