MCID: EXT054
MIFTS: 31

Extra-Adrenal Pheochromocytoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Extra-Adrenal Pheochromocytoma

MalaCards integrated aliases for Extra-Adrenal Pheochromocytoma:

Name: Extra-Adrenal Pheochromocytoma 12 15
Pheochromocytoma, Extra-Adrenal 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050936
UMLS 70 C1257877

Summaries for Extra-Adrenal Pheochromocytoma

Disease Ontology : 12 A malignant pheochromocytoma that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.

MalaCards based summary : Extra-Adrenal Pheochromocytoma, also known as pheochromocytoma, extra-adrenal, is related to nonsyndromic paraganglioma and pheochromocytoma-paraganglioma. An important gene associated with Extra-Adrenal Pheochromocytoma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Prion disease and Carbon metabolism. Affiliated tissues include thyroid, heart and cortex, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Extra-Adrenal Pheochromocytoma

Diseases related to Extra-Adrenal Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 nonsyndromic paraganglioma 29.9 SDHB RET CHGA
2 pheochromocytoma-paraganglioma 29.7 TMEM127 SDHD SDHC SDHB SDHA RET
3 malignant pheochromocytoma 29.7 SYP SDHB PNMT CHGA
4 adenoma 29.6 SYP RET CHGA
5 thyroid gland medullary carcinoma 29.4 SYP RET CHGA
6 ganglioneuroma 29.3 SYP RET PNMT CHGA
7 neuroblastoma 28.7 SYP SDHB RET NF1 CHGA
8 neuroendocrine tumor 28.6 SYP SDHD SDHB SDHA RET CHGA
9 pheochromocytoma 28.6 TMEM127 SYP SDHD SDHC SDHB SDHAF2
10 hereditary paraganglioma-pheochromocytoma syndromes 28.4 TMEM127 SDHD SDHC SDHB SDHAF2 SDHA
11 gastrointestinal stromal tumor 28.3 SYP SDHD SDHC SDHB SDHA NF1
12 paraganglioma 28.0 TMEM127 SYP SDHD SDHC SDHB SDHAF2
13 von hippel-lindau syndrome 28.0 TMEM127 SDHD SDHC SDHB SDHAF2 RET
14 adrenal gland pheochromocytoma 11.1
15 plethora of newborn 10.3 SDHD SDHB
16 atrial standstill 1 10.3
17 dermis tumor 10.3 SDHD SDHA
18 rare tumor 10.2
19 spastic paraplegia 38, autosomal dominant 10.2 SDHB SDHA
20 hereditary renal cell carcinoma 10.2 SDHB SDHA
21 horner's syndrome 10.2 SDHD NF1
22 b-lymphoblastic leukemia/lymphoma with hypodiploidy 10.1 SDHA RET
23 paragangliomas 4 10.1
24 respiratory failure 10.1
25 renovascular hypertension 10.1
26 gangliocytoma 10.1
27 skin lipoma 10.1 RET NF1
28 sporadic pheochromocytoma/secreting paraganglioma 10.1 SDHD SDHB RET
29 neurofibromatosis, type ii 10.1 SDHD SDHB NF1
30 neuronal intestinal dysplasia, type b 10.0 SYP RET
31 optic nerve astrocytoma 10.0 SYP NF1
32 hypoganglionosis 10.0 SYP RET
33 subglottis benign neoplasm 10.0 SDHC SDHB NF1
34 cowden syndrome 1 10.0 SDHD SDHB NF1
35 cranial nerve palsy 10.0 SYP SDHD SDHB
36 subungual glomus tumor 10.0 SYP NF1
37 glomus tumor 10.0 SYP SDHD SDHB
38 spinal cord oligodendroglioma 10.0 SYP NF1
39 ovarian germ cell teratoma 10.0 SYP RET
40 aortic aneurysm, familial abdominal, 1 10.0
41 cardiac arrhythmia 10.0
42 hypertension, essential 10.0
43 thyroid carcinoma, familial medullary 10.0
44 gallbladder disease 1 10.0
45 cervical cancer 10.0
46 meningioma, familial 10.0
47 cyanosis, transient neonatal 10.0
48 tumor predisposition syndrome 10.0
49 cutaneous telangiectasia and cancer syndrome, familial 10.0
50 extrapulmonary tuberculosis 10.0

Graphical network of the top 20 diseases related to Extra-Adrenal Pheochromocytoma:



Diseases related to Extra-Adrenal Pheochromocytoma

Symptoms & Phenotypes for Extra-Adrenal Pheochromocytoma

MGI Mouse Phenotypes related to Extra-Adrenal Pheochromocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 CHGA NF1 PNMT RET SDHA SDHB
2 neoplasm MP:0002006 9.35 NF1 RET SDHB SDHC SDHD
3 normal MP:0002873 9.1 NF1 PNMT RET SDHB SDHD SYP

Drugs & Therapeutics for Extra-Adrenal Pheochromocytoma

Search Clinical Trials , NIH Clinical Center for Extra-Adrenal Pheochromocytoma

Genetic Tests for Extra-Adrenal Pheochromocytoma

Anatomical Context for Extra-Adrenal Pheochromocytoma

MalaCards organs/tissues related to Extra-Adrenal Pheochromocytoma:

40
Thyroid, Heart, Cortex, Lymph Node, Spinal Cord, Breast, Appendix

Publications for Extra-Adrenal Pheochromocytoma

Articles related to Extra-Adrenal Pheochromocytoma:

(show top 50) (show all 266)
# Title Authors PMID Year
1
Consensus on molecular imaging and theranostics in neuroendocrine neoplasms. 61
33588146 2021
2
Pheochromocytoma of the organ of Zuckerkandl. 61
33299507 2021
3
Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature. 61
33407379 2021
4
Open abdominal aortic aneurysm repair with incidental finding of an extra-adrenal pheochromocytoma of the organ of Zuckerkandl. 61
32838691 2020
5
Bladder Paraganglioma Mimicking a Tumor Contained in a Ureterocele. 61
32461167 2020
6
Successful transurethral resection of the prostate in ectopic prostate pheochromocytoma: A case report. 61
32332642 2020
7
Successful Pregnancy Outcomes After Laparoscopic Management of Pheochromocytoma. 61
33102719 2020
8
Laparoscopic Excision of an Extra-Adrenal Pheochromocytoma (Paraganglioma) of the Organ of Zuckerkandl. 61
33102725 2020
9
Invasion of Pheochromocytoma from the Caudal Vena Cava to the Right Ventricular Cavity in a Dog. 61
32095312 2020
10
Functional paraganglioma of the bladder: Both radiographic-negative and laboratory-negative case. 61
32743403 2019
11
Renal Infarction Associated With Extra-Adrenal Pheochromocytoma. 61
30851287 2019
12
Occult extra-adrenal pheochromocytoma in the urinary bladder. 61
30852507 2019
13
Incidence and predictive factors of hypoglycemia after pheochromocytoma resection. 61
30467902 2019
14
Extra-adrenal pheochromocytoma presenting as inverse takotsubo-pattern cardiomyopathy treated with surgical resection. 61
30567218 2018
15
Extra-adrenal Pheochromocytoma Associated With Segmental Renal Artery Compression and Pseudostenosis. 61
29800631 2018
16
Use of desflurane during anesthesia for resection of extra-adrenal pheochromocytoma: a case report. 61
32025984 2018
17
Laparoscopic management of paraganglioma in a pregnant woman: a case report. 61
29570256 2018
18
A Rare Case Report of Extra-adrenal Pheochromocytoma with Normal Blood Pressure: Is that Possible? 61
30357026 2018
19
Pheochromocytoma and paraganglioma in Fontan patients: Common more than expected. 61
30033572 2018
20
Partial Cystectomy of Paraganglioma of the Urinary Bladder Before Living Kidney Transplantation: Case Report. 61
29661460 2018
21
Proceedings of the 2017 National Toxicology Program Satellite Symposium. 61
29113559 2017
22
Pheochromocytoma of the bladder. 61
28953019 2017
23
Extra-adrenal pheochromocytoma at the organ of Zuckerkandl: a case report and literature review. 61
28491185 2017
24
Expanding the horizon of robotic surgery to large pelvic paraganglioma. 61
27812903 2017
25
An unusual cause of back pain: a case of large nonfunctioning retroperitoneal paraganglioma presented as a large cystic lesion. A case report and review of literature. 61
28458869 2017
26
Paraganglioma of the bladder in a kidney transplant recipient: A case report. 61
28413667 2017
27
Paraganglioma, pituitary adenoma, and osteosarcoma in a dog. 61
27428777 2016
28
Pheochromocytoma of the pancreas: A report of three cases and a literature review. 61
27446377 2016
29
Laparoscopic Resection of a Renal Hilar Pheochromocytoma in an Adolescent With a Circumaortic Left Renal Vein. 61
26876463 2016
30
Traumatic Rupture of Extra-adrenal Pheochromocytoma. 61
27215711 2016
31
A Peculiar Primary Paraganglioma of the Distal Thumb. 61
26971069 2016
32
Life-threatening protamine allergic reaction in a patient with extra-adrenal pheochromocytoma undergoing off-pump coronary artery bypass grafting. 61
27052084 2016
33
ANESTHETIC MANAGEMENT IN UNEXPECTED EXTRA- ADRENAL PHEOCROMOCYTOMA PRESENTING WITH THORACIC SPINAL CORD COMPRESSION. 61
27382822 2016
34
Transformation of a Nonfunctional Paraganglioma With I-123 MIBG Scintigraphy Correlation: A Case Report. 61
26765464 2016
35
Anesthetic management of a rare case of extra-adrenal pheochromocytoma. 61
26957701 2016
36
[A Case of Undiagnosed Extra-adrenal Pheochromocytoma in an Adult Patient with Single Ventricle Circulation after the Bidirectional Glenn Operation]. 61
26466501 2015
37
A Rare Case of Adrenal Pheochromocytoma with Unusual Clinical and Biochemical Presentation: 
A Case Report and Literature Review. 61
26421121 2015
38
Primary malignant hepatic paraganglioma mimicking liver tumor: A case report. 61
26622647 2015
39
Non-functioning paraganglioma occurring in the urinary bladder: A case report and review of the literature. 61
26171023 2015
40
A rare case of extra-adrenal pheochromocytoma localized to the ovary and detected via abdominal computed tomography angiography. 61
25621050 2015
41
A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma. 61
26370861 2015
42
Pheochromocytoma associated with von Hippel-lindau disease in a Pakistani family. 61
25657563 2015
43
Management of anesthesia in unspecified extra-adrenal pheochromocytoma patient who used beta-blocker. 61
25538499 2014
44
Acrocyanosis in a young adult: a rare presentation of extra-adrenal pheochromocytoma. 61
24872481 2014
45
Retroperitoneal pheochromocytoma with thorax and bilateral neck chemodectoma in patients with multiorgan sarcoidosis. 61
24458174 2014
46
Robot assisted laparoscopic excision of a paraganglioma: new therapeutic approach. 61
24856498 2014
47
Laparoscopic resection of adrenal and extra-adrenal pheochromocytoma. 61
23469777 2013
48
An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. 61
23905134 2013
49
An unusual combination of extra-adrenal pheochromocytoma and arteriovenous malformation of the ureter in a young adult. 61
23616332 2013
50
Diagnosis and treatment of extra-adrenal pheochromocytoma of urinary bladder: case report and literature review. 61
24179580 2013

Variations for Extra-Adrenal Pheochromocytoma

Expression for Extra-Adrenal Pheochromocytoma

Search GEO for disease gene expression data for Extra-Adrenal Pheochromocytoma.

Pathways for Extra-Adrenal Pheochromocytoma

GO Terms for Extra-Adrenal Pheochromocytoma

Cellular components related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.46 SDHD SDHC SDHB SDHA
2 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 9.43 SDHC SDHB SDHA
2 aerobic respiration GO:0009060 9.37 SDHC SDHB
3 tricarboxylic acid cycle GO:0006099 9.35 SDHD SDHC SDHB SDHAF2 SDHA
4 respiratory electron transport chain GO:0022904 9.32 SDHB SDHA
5 succinate metabolic process GO:0006105 9.16 SDHB SDHA
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHD SDHC SDHAF2 SDHA

Molecular functions related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHC SDHA
2 ubiquinone binding GO:0048039 9.26 SDHD SDHB
3 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
5 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Extra-Adrenal Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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