MCID: EXT054
MIFTS: 30

Extra-Adrenal Pheochromocytoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Extra-Adrenal Pheochromocytoma

MalaCards integrated aliases for Extra-Adrenal Pheochromocytoma:

Name: Extra-Adrenal Pheochromocytoma 12 15
Pheochromocytoma, Extra-Adrenal 73
Extraadrenal Pheochromocytoma 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0050936
UMLS 73 C1257877

Summaries for Extra-Adrenal Pheochromocytoma

Disease Ontology : 12 An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.

MalaCards based summary : Extra-Adrenal Pheochromocytoma, also known as pheochromocytoma, extra-adrenal, is related to paragangliomas 1 and phaeochromocytoma. An important gene associated with Extra-Adrenal Pheochromocytoma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Affiliated tissues include ovary and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Extra-Adrenal Pheochromocytoma

Diseases related to Extra-Adrenal Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 31.1 SDHB SDHC SDHD
2 phaeochromocytoma 29.7 SDHAF2 SDHB SDHC SDHD
3 pheochromocytoma 29.6 PNMT SDHAF2 SDHB SDHC SDHD
4 paraganglioma 28.2 SDHAF2 SDHB SDHC SDHD
5 paragangliomas 4 11.5
6 retinoblastoma 9.9
7 aging 9.9
8 extrapulmonary tuberculosis 9.9
9 malignant hypertension 9.9
10 arteriovenous malformation 9.9
11 heart disease 9.9
12 renovascular hypertension 9.9
13 ganglioneuroma 9.9
14 glomus tumor 9.7 SDHB SDHD
15 multiple endocrine neoplasia, type iia 9.6 SDHB SDHD
16 chondroma 9.5 SDHB SDHC SDHD
17 paraganglioma and gastric stromal sarcoma 9.5 SDHB SDHC SDHD
18 carney triad 9.5 SDHB SDHC SDHD
19 sporadic pheochromocytoma 9.5 SDHB SDHC SDHD
20 lymphatic system disease 9.4 SDHB SDHC SDHD
21 neurofibromatosis, type iv, of riccardi 9.4 SDHB SDHC SDHD
22 multiple endocrine neoplasia, type i 9.4 SDHB SDHD
23 cowden disease 9.3 SDHB SDHC SDHD
24 endocrine gland cancer 9.3 SDHB SDHC SDHD
25 multiple endocrine neoplasia 9.3 PNMT SDHB SDHC
26 gastrointestinal stromal tumor 9.3 SDHB SDHC SDHD
27 von hippel-lindau syndrome 8.9 PNMT SDHB SDHC SDHD
28 neural crest tumor 8.6 SDHAF2 SDHB SDHC SDHD
29 persistent generalized lymphadenopathy 8.6 SDHAF2 SDHB SDHC SDHD
30 lymph node disease 8.6 SDHAF2 SDHB SDHC SDHD
31 hereditary paraganglioma-pheochromocytoma syndromes 8.6 SDHAF2 SDHB SDHC SDHD
32 mitochondrial complex ii deficiency 8.6 SDHAF2 SDHB SDHC SDHD
33 adrenal medulla cancer 7.4 DGKH PNMT SDHAF2 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Extra-Adrenal Pheochromocytoma:



Diseases related to Extra-Adrenal Pheochromocytoma

Symptoms & Phenotypes for Extra-Adrenal Pheochromocytoma

GenomeRNAi Phenotypes related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD

Drugs & Therapeutics for Extra-Adrenal Pheochromocytoma

Search Clinical Trials , NIH Clinical Center for Extra-Adrenal Pheochromocytoma

Genetic Tests for Extra-Adrenal Pheochromocytoma

Genetic tests related to Extra-Adrenal Pheochromocytoma:

# Genetic test Affiliating Genes
1 Extraadrenal Pheochromocytoma 29

Anatomical Context for Extra-Adrenal Pheochromocytoma

MalaCards organs/tissues related to Extra-Adrenal Pheochromocytoma:

41
Ovary, Heart

Publications for Extra-Adrenal Pheochromocytoma

Articles related to Extra-Adrenal Pheochromocytoma:

(show all 45)
# Title Authors Year
1
Extra-adrenal Pheochromocytoma Associated With Segmental Renal Artery Compression and Pseudostenosis. ( 29800631 )
2018
2
Extra-adrenal pheochromocytoma at the organ of Zuckerkandl: a case report and literature review. ( 28491185 )
2017
3
Life-threatening protamine allergic reaction in a patient with extra-adrenal pheochromocytoma undergoing off-pump coronary artery bypass grafting. ( 27052084 )
2016
4
Traumatic Rupture of Extra-adrenal Pheochromocytoma. ( 27215711 )
2016
5
Anesthetic management of a rare case of extra-adrenal pheochromocytoma. ( 26957701 )
2016
6
A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma. ( 26370861 )
2015
7
A rare case of extra-adrenal pheochromocytoma localized to the ovary and detected via abdominal computed tomography angiography. ( 25621050 )
2015
8
Management of anesthesia in unspecified extra-adrenal pheochromocytoma patient who used beta-blocker. ( 25538499 )
2014
9
Acrocyanosis in a young adult: a rare presentation of extra-adrenal pheochromocytoma. ( 24872481 )
2014
10
Diagnosis and treatment of extra-adrenal pheochromocytoma of urinary bladder: case report and literature review. ( 24179580 )
2013
11
An unusual combination of extra-adrenal pheochromocytoma and arteriovenous malformation of the ureter in a young adult. ( 23616332 )
2013
12
An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. ( 23905134 )
2013
13
Laparoscopic resection of adrenal and extra-adrenal pheochromocytoma. ( 23469777 )
2013
14
Outcomes of resection of extra-adrenal pheochromocytomas/paragangliomas in the laparoscopic era: a comparison with adrenal pheochromocytoma. ( 22936431 )
2013
15
Extra-adrenal pheochromocytoma after operation of congenital heart disease: a case report of 18-year-old boy. ( 22792537 )
2012
16
Paraganglioma: not just an extra-adrenal pheochromocytoma. ( 22086065 )
2012
17
Laparoscopic resection of extra-adrenal pheochromocytoma in paediatric age. ( 22303083 )
2012
18
Coexistent extra adrenal pheochromocytoma and extrapulmonary tuberculosis: a case report and review of literature. ( 23205367 )
2012
19
Unexpected visitor on FDG PET/CT--brown adipose tissue (BAT) in mesentery in a case of retroperitoneal extra-adrenal pheochromocytoma: is the BAT activation secondary to catecholamine-secreting pheochromocytoma? ( 22475922 )
2012
20
Transarterial embolization and doxorubicin eluting beads-transarterial chemoembolization (DEB-TACE) of malignant extra-adrenal pheochromocytoma. ( 21437761 )
2011
21
Extra-adrenal pheochromocytoma in the organ of Zuckerkandl: diagnosis and treatment strategies. ( 21374546 )
2011
22
Extra-adrenal Pheochromocytoma in an Adolescent. ( 21691539 )
2011
23
CT-guided fine needle aspiration cytology diagnosis of extra-adrenal pheochromocytoma. ( 21042531 )
2010
24
Malignant extra-adrenal pheochromocytoma--a diagnostic dilemma. ( 20812189 )
2010
25
The first laparoscopic resection of extra-adrenal pheochromocytoma using the da Vinci robotic system. ( 18999978 )
2009
26
An extra-adrenal pheochromocytoma of the organ of Zuckerkandl: report of a case. ( 19938747 )
2009
27
[Extra-adrenal pheochromocytoma associated to SDHD gene mutation]. ( 19318336 )
2009
28
Malignant extra-adrenal pheochromocytoma caused by an SDHB intronic variation leading to a 54-bp deletion in exon 4. ( 19411806 )
2009
29
Concurrent robotic partial adrenalectomy and extra-adrenal pheochromocytoma resection in a pediatric patient with von Hippel-Lindau disease. ( 18690816 )
2008
30
Small extra-adrenal pheochromocytoma causing severe hypertension in an elderly patient. ( 17139794 )
2006
31
Extra-adrenal pheochromocytoma presenting with life-threatening ventricular tachycardia: a case report. ( 15696793 )
2004
32
[Extra adrenal pheochromocytoma. Report of two cases]. ( 12768996 )
2003
33
A case of metastatic extra-adrenal pheochromocytoma 12 years after surgery. ( 11924720 )
2002
34
Successful treatment with paclitaxel of a patient with metastatic extra-adrenal pheochromocytoma (paraganglioma). A case report and review of the literature. ( 10803928 )
2000
35
Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas. ( 11127918 )
2000
36
Extra-adrenal pheochromocytoma in pregnancy: ultrasonography and magnetic resonance imaging findings. ( 7704675 )
1995
37
Discrepancy between PNMT presence and relative lack of adrenaline production in extra-adrenal pheochromocytoma. ( 7967610 )
1994
38
Flow cytometric DNA analysis for the determination of malignant potential in adrenal and extra-adrenal pheochromocytomas or paragangliomas. ( 8239937 )
1993
39
Extra-adrenal pheochromocytoma-ganglioneuroma. A case report. ( 1300605 )
1992
40
[Extra-adrenal pheochromocytoma. Report of two cases]. ( 2252350 )
1990
41
Immunoreactive corticotropin-releasing hormone, growth hormone-releasing hormone, somatostatin, and peptide histidine methionine are present in adrenal pheochromocytomas, but not in extra-adrenal pheochromocytoma. ( 1969422 )
1990
42
Extra-adrenal pheochromocytoma (paraganglioma) in a cat. ( 2370206 )
1990
43
Experience with extra-adrenal pheochromocytoma. ( 2795745 )
1989
44
Extra-adrenal pheochromocytoma manifesting renovascular hypertension. ( 3668590 )
1987
45
Extra-adrenal pheochromocytoma producing renal artery stenosis. ( 950714 )
1976

Variations for Extra-Adrenal Pheochromocytoma

Expression for Extra-Adrenal Pheochromocytoma

Search GEO for disease gene expression data for Extra-Adrenal Pheochromocytoma.

Pathways for Extra-Adrenal Pheochromocytoma

GO Terms for Extra-Adrenal Pheochromocytoma

Cellular components related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.56 SDHAF2 SDHB SDHC SDHD
2 mitochondrial inner membrane GO:0005743 9.33 SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.5 SDHB SDHC SDHD
2 electron transport chain GO:0022900 9.26 SDHB SDHC
3 aerobic respiration GO:0009060 9.16 SDHB SDHC
4 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHAF2 SDHC SDHD
5 tricarboxylic acid cycle GO:0006099 8.92 SDHAF2 SDHB SDHC SDHD

Molecular functions related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 heme binding GO:0020037 9.32 SDHC SDHD
3 ubiquinone binding GO:0048039 9.26 SDHB SDHD
4 succinate dehydrogenase activity GO:0000104 8.96 SDHC SDHD
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Extra-Adrenal Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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