MCID: EXT054
MIFTS: 36

Extra-Adrenal Pheochromocytoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Extra-Adrenal Pheochromocytoma

MalaCards integrated aliases for Extra-Adrenal Pheochromocytoma:

Name: Extra-Adrenal Pheochromocytoma 12 15
Pheochromocytoma, Extra-Adrenal 73
Extraadrenal Pheochromocytoma 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0050936
UMLS 73 C1257877

Summaries for Extra-Adrenal Pheochromocytoma

Disease Ontology : 12 An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.

MalaCards based summary : Extra-Adrenal Pheochromocytoma, also known as pheochromocytoma, extra-adrenal, is related to pheochromocytoma and paragangliomas 1. An important gene associated with Extra-Adrenal Pheochromocytoma is SDHD (Succinate Dehydrogenase Complex Subunit D), and among its related pathways/superpathways are Metabolism and Carbon metabolism. Affiliated tissues include heart, lymph node and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Extra-Adrenal Pheochromocytoma

Diseases related to Extra-Adrenal Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 pheochromocytoma 32.2 PNMT SDHAF2 SDHB SDHC SDHD
2 paragangliomas 1 31.8 SDHB SDHC SDHD
3 paraganglioma 30.1 SDHAF2 SDHB SDHC SDHD
4 paragangliomas 4 11.7
5 adrenal gland pheochromocytoma 10.2
6 glomus vagale tumor 10.1
7 thyroid carcinoma, familial medullary 10.0
8 retinoblastoma 10.0
9 neuroblastoma 10.0
10 cervical cancer 10.0
11 diabetes mellitus 10.0
12 extrapulmonary tuberculosis 10.0
13 thrombosis 10.0
14 malignant hypertension 10.0
15 arteriovenous malformation 10.0
16 heart disease 10.0
17 allergic hypersensitivity disease 10.0
18 renovascular hypertension 10.0
19 ganglioneuroma 10.0
20 ureteral obstruction 10.0
21 glomus tumor 9.9 SDHB SDHD
22 multiple endocrine neoplasia, type i 9.9 SDHB SDHD
23 malignant pheochromocytoma 9.9 PNMT SDHB
24 multiple endocrine neoplasia, type iia 9.9 SDHB SDHD
25 chondroma 9.8 SDHB SDHC SDHD
26 paraganglioma and gastric stromal sarcoma 9.8 SDHB SDHC SDHD
27 carney triad 9.8 SDHB SDHC SDHD
28 plethora of newborn 9.8 SDHB SDHC SDHD
29 sporadic pheochromocytoma 9.8 SDHB SDHC SDHD
30 lymphatic system disease 9.8 SDHB SDHC SDHD
31 neurofibromatosis, type iv, of riccardi 9.8 SDHB SDHC SDHD
32 cowden disease 9.8 SDHB SDHC SDHD
33 autosomal genetic disease 9.8 SDHB SDHD
34 gastrointestinal stromal tumor 9.8 SDHB SDHC SDHD
35 multiple endocrine neoplasia 9.8 PNMT SDHB SDHC
36 neural crest tumor 9.7 SDHAF2 SDHB SDHC SDHD
37 persistent generalized lymphadenopathy 9.7 SDHAF2 SDHB SDHC SDHD
38 hereditary paraganglioma-pheochromocytoma syndromes 9.7 SDHAF2 SDHB SDHC SDHD
39 lymph node disease 9.7 SDHAF2 SDHB SDHC SDHD
40 mitochondrial complex ii deficiency 9.7 SDHAF2 SDHB SDHC SDHD
41 endocrine organ benign neoplasm 9.7 SDHAF2 SDHB SDHC SDHD
42 von hippel-lindau syndrome 9.7 PNMT SDHB SDHC SDHD
43 adrenal medulla cancer 9.5 PNMT SDHAF2 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Extra-Adrenal Pheochromocytoma:



Diseases related to Extra-Adrenal Pheochromocytoma

Symptoms & Phenotypes for Extra-Adrenal Pheochromocytoma

GenomeRNAi Phenotypes related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD

Drugs & Therapeutics for Extra-Adrenal Pheochromocytoma

Search Clinical Trials , NIH Clinical Center for Extra-Adrenal Pheochromocytoma

Genetic Tests for Extra-Adrenal Pheochromocytoma

Genetic tests related to Extra-Adrenal Pheochromocytoma:

# Genetic test Affiliating Genes
1 Extraadrenal Pheochromocytoma 29

Anatomical Context for Extra-Adrenal Pheochromocytoma

MalaCards organs/tissues related to Extra-Adrenal Pheochromocytoma:

41
Heart, Lymph Node, Ovary, Thyroid

Publications for Extra-Adrenal Pheochromocytoma

Articles related to Extra-Adrenal Pheochromocytoma:

(show top 50) (show all 105)
# Title Authors Year
1
Extra-adrenal Pheochromocytoma Associated With Segmental Renal Artery Compression and Pseudostenosis. ( 29800631 )
2018
2
A Rare Case Report of Extra-adrenal Pheochromocytoma with Normal Blood Pressure: Is that Possible? ( 30357026 )
2018
3
Extra-adrenal pheochromocytoma at the organ of Zuckerkandl: a case report and literature review. ( 28491185 )
2017
4
Life-threatening protamine allergic reaction in a patient with extra-adrenal pheochromocytoma undergoing off-pump coronary artery bypass grafting. ( 27052084 )
2016
5
Traumatic Rupture of Extra-adrenal Pheochromocytoma. ( 27215711 )
2016
6
Anesthetic management of a rare case of extra-adrenal pheochromocytoma. ( 26957701 )
2016
7
Traumatic Rupture of Extra-adrenal Pheochromocytoma. ( 30454134 )
2016
8
A Patient with an Extra-adrenal Pheochromocytoma and Germ-line SDHB Mutation Accompanied by an Atypical Meningioma. ( 26370861 )
2015
9
A rare case of extra-adrenal pheochromocytoma localized to the ovary and detected via abdominal computed tomography angiography. ( 25621050 )
2015
10
Management of anesthesia in unspecified extra-adrenal pheochromocytoma patient who used beta-blocker. ( 25538499 )
2014
11
Acrocyanosis in a young adult: a rare presentation of extra-adrenal pheochromocytoma. ( 24872481 )
2014
12
Diagnosis and treatment of extra-adrenal pheochromocytoma of urinary bladder: case report and literature review. ( 24179580 )
2013
13
An unusual combination of extra-adrenal pheochromocytoma and arteriovenous malformation of the ureter in a young adult. ( 23616332 )
2013
14
An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. ( 23905134 )
2013
15
Laparoscopic resection of adrenal and extra-adrenal pheochromocytoma. ( 23469777 )
2013
16
Extra-adrenal pheochromocytoma after operation of congenital heart disease: a case report of 18-year-old boy. ( 22792537 )
2012
17
Paraganglioma: not just an extra-adrenal pheochromocytoma. ( 22086065 )
2012
18
Laparoscopic resection of extra-adrenal pheochromocytoma in paediatric age. ( 22303083 )
2012
19
Coexistent extra adrenal pheochromocytoma and extrapulmonary tuberculosis: a case report and review of literature. ( 23205367 )
2012
20
Unexpected visitor on FDG PET/CT--brown adipose tissue (BAT) in mesentery in a case of retroperitoneal extra-adrenal pheochromocytoma: is the BAT activation secondary to catecholamine-secreting pheochromocytoma? ( 22475922 )
2012
21
Response to "CT-guided fine needle aspiration cytology diagnosis of extra-adrenal pheochromocytoma". ( 22438635 )
2012
22
Transarterial embolization and doxorubicin eluting beads-transarterial chemoembolization (DEB-TACE) of malignant extra-adrenal pheochromocytoma. ( 21437761 )
2011
23
Extra-adrenal pheochromocytoma in the organ of Zuckerkandl: diagnosis and treatment strategies. ( 21374546 )
2011
24
Extra-adrenal Pheochromocytoma in an Adolescent. ( 21691539 )
2011
25
CT-guided fine needle aspiration cytology diagnosis of extra-adrenal pheochromocytoma. ( 21042531 )
2010
26
Malignant extra-adrenal pheochromocytoma--a diagnostic dilemma. ( 20812189 )
2010
27
The first laparoscopic resection of extra-adrenal pheochromocytoma using the da Vinci robotic system. ( 18999978 )
2009
28
An extra-adrenal pheochromocytoma of the organ of Zuckerkandl: report of a case. ( 19938747 )
2009
29
[Extra-adrenal pheochromocytoma associated to SDHD gene mutation]. ( 19318336 )
2009
30
Malignant extra-adrenal pheochromocytoma caused by an SDHB intronic variation leading to a 54-bp deletion in exon 4. ( 19411806 )
2009
31
Robotic-assisted partial cystectomy for recurrent extra-adrenal pheochromocytoma. ( 27628452 )
2009
32
Concurrent robotic partial adrenalectomy and extra-adrenal pheochromocytoma resection in a pediatric patient with von Hippel-Lindau disease. ( 18690816 )
2008
33
Extra-adrenal pheochromocytoma 12 years in the making. ( 18190420 )
2008
34
Tako-tsubo-like cardiomyopathy and extra-adrenal pheochromocytoma: case report and literature review. ( 18193368 )
2008
35
Sustained hypotension complicating an extra-adrenal pheochromocytoma. ( 18464747 )
2008
36
Extra-adrenal pheochromocytoma involving the organ of Zuckerkandl. ( 18549902 )
2008
37
Advanced gastric carcinoma combined with extra-adrenal pheochromocytoma resected after three courses of S-1 and cisplatin as neoadjuvant chemotherapy: report of a case. ( 18560969 )
2008
38
Extra adrenal pheochromocytoma of urinary bladder. ( 23133055 )
2008
39
Extra-adrenal pheochromocytoma: diagnosis and management. ( 17239321 )
2007
40
Laparoscopic resection of an extra-adrenal pheochromocytoma. ( 17710068 )
2007
41
Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients. ( 17923216 )
2007
42
A rare case of extra-adrenal pheochromocytoma masquerading as an ovarian mass treated by laparoscopic surgery. ( 18179144 )
2007
43
Extra-adrenal pheochromocytoma. ( 18251381 )
2007
44
Torsades de Pointes: a rare complication of an extra-adrenal pheochromocytoma. ( 18344633 )
2007
45
Small extra-adrenal pheochromocytoma causing severe hypertension in an elderly patient. ( 17139794 )
2006
46
Transperitoneal, transmesocolic approach for laparoscopic excision of an extra-adrenal pheochromocytoma. ( 16796436 )
2006
47
Extra-adrenal pheochromocytoma in an adolescent. ( 16912895 )
2006
48
Extra-adrenal pheochromocytoma involving the left atrium: an infrequent pathologic occurrence. ( 17140976 )
2006
49
Conservative management of extra-adrenal pheochromocytoma during pregnancy. ( 15863575 )
2005
50
Ventricular tachycardia and spontaneous rupture of an extra-adrenal pheochromocytoma case. ( 15960073 )
2005

Variations for Extra-Adrenal Pheochromocytoma

Expression for Extra-Adrenal Pheochromocytoma

Search GEO for disease gene expression data for Extra-Adrenal Pheochromocytoma.

Pathways for Extra-Adrenal Pheochromocytoma

GO Terms for Extra-Adrenal Pheochromocytoma

Cellular components related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.56 SDHAF2 SDHB SDHC SDHD
2 mitochondrial inner membrane GO:0005743 9.33 SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.5 SDHB SDHC SDHD
2 electron transport chain GO:0022900 9.26 SDHB SDHC
3 aerobic respiration GO:0009060 9.16 SDHB SDHC
4 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHAF2 SDHC SDHD
5 tricarboxylic acid cycle GO:0006099 8.92 SDHAF2 SDHB SDHC SDHD

Molecular functions related to Extra-Adrenal Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
2 heme binding GO:0020037 9.26 SDHC SDHD
3 ubiquinone binding GO:0048039 9.13 SDHB SDHC SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Extra-Adrenal Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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