MCID: EXT007
MIFTS: 39

Extracutaneous Mastocytoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Extracutaneous Mastocytoma

MalaCards integrated aliases for Extracutaneous Mastocytoma:

Name: Extracutaneous Mastocytoma 12 59 15 73
Mastocytoma 44 73
Mast Cell Neoplasm 73
Benign Mastocytoma 73

Characteristics:

Orphanet epidemiological data:

59
extracutaneous mastocytoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:4659
ICD10 33 D47.09
MeSH 44 D034801
NCIt 50 C7136
SNOMED-CT 68 63175003
Orphanet 59 ORPHA66662
UMLS via Orphanet 74 C0272202
ICD10 via Orphanet 34 C96.2

Summaries for Extracutaneous Mastocytoma

MalaCards based summary : Extracutaneous Mastocytoma, also known as mastocytoma, is related to cutaneous solitary mastocytoma and mast cell neoplasm. An important gene associated with Extracutaneous Mastocytoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. Affiliated tissues include bone, skin and bone marrow.

Wikipedia : 76 Extracutaneous mastocytoma presents with benign appearing mast cells occurring in sites other than the... more...

Related Diseases for Extracutaneous Mastocytoma

Diseases related to Extracutaneous Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 cutaneous solitary mastocytoma 33.7 CD2 KIT
2 mast cell neoplasm 33.0 CD2 KIT
3 mastocytosis, cutaneous 32.9 CD2 KIT
4 mastocytosis 30.6 CD2 KIT
5 systemic mastocytosis 30.0 CD2 KIT
6 histiocytoma 29.8 KIT PTPRC
7 cutaneous mastocytoma 12.7
8 benign mastocytoma 12.1
9 mast-cell sarcoma 11.3
10 urticaria 10.2
11 gallbladder leiomyoma 10.1 CD34 KIT
12 leiomyoma 10.1 CD34 KIT
13 lung leiomyosarcoma 10.1 CD34 KIT
14 liver leiomyoma 10.1 CD34 KIT
15 deep leiomyoma 10.1 CD34 KIT
16 mediastinal cancer 10.1 CD33 KIT
17 small intestine leiomyosarcoma 10.1 CD34 KIT
18 small intestinal sarcoma 10.1 CD34 KIT
19 gallbladder sarcoma 10.1 CD34 KIT
20 prostate leiomyosarcoma 10.1 CD34 KIT
21 sm-ahnmd 10.1 CD2 KIT
22 indolent systemic mastocytosis 10.1 CD2 KIT
23 helsmoortel-van der aa syndrome 10.1 CD33 KIT
24 plexiform schwannoma 10.1 CD34 KIT
25 sclerosing cholangitis, neonatal 10.1
26 peritoneal benign neoplasm 10.1 CD34 KIT
27 diffuse peritoneal leiomyomatosis 10.1 CD34 KIT
28 breast angiosarcoma 10.1 CD34 KIT
29 senile angioma 10.1 CD34 KIT
30 angiomyoma 10.1 CD34 KIT
31 spindle cell liposarcoma 10.1 CD34 KIT
32 mesenchymal cell neoplasm 10.1 CD34 KIT
33 cardiovascular organ benign neoplasm 10.1 CD34 KIT
34 benign perivascular tumor 10.1 CD34 KIT
35 endometrial small cell carcinoma 10.1 KIT PTPRC
36 small cell carcinoma 10.1 KIT PTPRC
37 testicular infarct 10.1 KIT PTPRC
38 nervous system benign neoplasm 10.1 CD34 KIT
39 muscle cancer 10.0 CD34 KIT
40 liver inflammatory pseudotumor 10.0 CD34 PTPRC
41 vulvar sarcoma 10.0 CD34 PTPRC
42 vascular cancer 10.0 CD34 KIT
43 chronic monocytic leukemia 10.0 CD34 PTPRC
44 myeloid sarcoma 10.0 KIT PTPRC
45 neurofibroma 10.0 CD34 KIT
46 langerhans cell histiocytosis 10.0
47 melanoma 10.0
48 histiocytosis 10.0
49 influenza 10.0
50 axillary lipoma 10.0 CD68 KIT

Graphical network of the top 20 diseases related to Extracutaneous Mastocytoma:



Diseases related to Extracutaneous Mastocytoma

Symptoms & Phenotypes for Extracutaneous Mastocytoma

Drugs & Therapeutics for Extracutaneous Mastocytoma

Search Clinical Trials , NIH Clinical Center for Extracutaneous Mastocytoma

Cochrane evidence based reviews: mastocytoma

Genetic Tests for Extracutaneous Mastocytoma

Anatomical Context for Extracutaneous Mastocytoma

MalaCards organs/tissues related to Extracutaneous Mastocytoma:

41
Bone, Skin, Bone Marrow, T Cells, Liver, Spleen, Small Intestine

Publications for Extracutaneous Mastocytoma

Articles related to Extracutaneous Mastocytoma:

(show top 50) (show all 485)
# Title Authors Year
1
Childhood solitary cutaneous mastocytoma: clinical manifestations, diagnosis, evaluation, and management. ( 30465511 )
2018
2
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. ( 28397975 )
2018
3
Pleomorphic mastocytoma in an adult. ( 29148588 )
2018
4
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279. ( 29463690 )
2018
5
Solitary mastocytoma in the eyelid of an adult. ( 29468227 )
2018
6
Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. ( 29710479 )
2018
7
Solitary mastocytoma presenting at birth. ( 29716178 )
2018
8
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma. ( 30356111 )
2018
9
The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma. ( 28580034 )
2017
10
Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma. ( 28918040 )
2017
11
Solitary mastocytoma with positive Darier's sign. ( 27057508 )
2016
12
Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations. ( 27802814 )
2016
13
Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway. ( 28127293 )
2016
14
Topical corticosteroids versus "wait and see" in the management of solitary mastocytoma in pediatric patients: a long-term follow-up. ( 25471152 )
2015
15
Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells. ( 24249003 )
2014
16
Bioengineering murine mastocytoma cells to produce anticoagulant heparin. ( 24326668 )
2014
17
Intramuscular electroporation of a P1A-encoding plasmid vaccine delays P815 mastocytoma growth. ( 24342164 )
2014
18
Cutaneous mast cell tumor (Mastocytoma): cyto- histopathological and haematological investigations. ( 24444100 )
2014
19
Role of lipid raft components and actin cytoskeleton in fibronectin-binding, surface expression, and de novo synthesis of integrin subunits in PGE2- or 8-Br-cAMP-stimulated mastocytoma P-815 cells. ( 24518258 )
2014
20
Solitary mastocytoma of the vulva. ( 24800094 )
2014
21
Case Report: Solitary mastocytoma treated successfully with topical tacrolimus. ( 25210620 )
2014
22
Solitary mastocytoma mimicking granuloma faciale. ( 25257118 )
2014
23
Solitary mastocytoma with associated pseudocarcinomatous hyperplasia. ( 23252514 )
2013
24
Intratumoural interleukin-2 therapy can induce regression of non-resectable mastocytoma in dogs. ( 23267141 )
2013
25
Behavior of the P1.HTR mastocytoma cell line implanted in the chorioallantoic membrane of chick embryos. ( 23314344 )
2013
26
Solitary mastocytoma of the eyelid. ( 23871296 )
2013
27
Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. ( 24072749 )
2013
28
Dermacase: Can you identify this condition? Solitary mastocytoma. ( 22977914 )
2012
29
NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation. ( 22583069 )
2012
30
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. ( 22677519 )
2012
31
Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. ( 22936666 )
2012
32
Induction of integrin β3 in PGE₂-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin. ( 21276770 )
2011
33
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. ( 21501463 )
2011
34
Solitary mastocytoma with histologic features of eosinophilic cellulites. ( 21540136 )
2011
35
Pathology quiz case 1. Pediatric solitary mastocytoma. ( 21768423 )
2011
36
Solitary mastocytoma in an adult with an unusual clinical presentation. ( 21839341 )
2011
37
A rare presentation of solitary mastocytoma in the palm of an infant. ( 19502121 )
2010
38
Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells. ( 19960020 )
2010
39
Mastocytoma in the common carpal sheath of the digital flexor tendons of a horse. ( 20148821 )
2010
40
Images for diagnosis. A vulva mastocytoma having grown for eighteen years. ( 20193267 )
2010
41
VEGF expression in dog mastocytoma. ( 20509299 )
2010
42
Growth of vascular smooth muscle cells on collagen I exposed to RBL-2H3 mastocytoma cells. ( 20511706 )
2010
43
PUFA-dependent alteration of oxidative parameters of a canine mastocytoma cell line. ( 21087915 )
2010
44
Characterization of an early signaling defect following Fc epsilonRI activation in the canine mastocytoma cell line, C2. ( 19135724 )
2009
45
Anti-cancer effect of two alkaloids: 2R and 2S-bgugaine on mastocytoma P815 and carcinoma Hep. ( 19401921 )
2009
46
Effect of radiation on vascular endothelial growth factor expression in the C2 canine mastocytoma cell line. ( 19719431 )
2009
47
Co-expression of P1A35-43/beta2m fusion protein and co-stimulatory molecule CD80 elicits effective anti-tumor immunity in the P815 mouse mastocytoma tumor model. ( 19787242 )
2009
48
Combined Mastocytoma-hemangioma in a Patient with Urticaria Pigmentosa. ( 27303182 )
2008
49
Adult onset, hypopigmented solitary mastocytoma: report of two cases. ( 18187823 )
2008
50
Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis. ( 18723263 )
2008

Variations for Extracutaneous Mastocytoma

Expression for Extracutaneous Mastocytoma

Search GEO for disease gene expression data for Extracutaneous Mastocytoma.

Pathways for Extracutaneous Mastocytoma

GO Terms for Extracutaneous Mastocytoma

Cellular components related to Extracutaneous Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.88 CD2 CD33 CD34 CD68 KIT PTPRC
2 plasma membrane GO:0005886 9.73 CD2 CD33 CD34 CD68 KIT PTPRC
3 cell surface GO:0009986 9.46 CD2 CD34 KIT PTPRC
4 cell periphery GO:0071944 9.37 CD34 PTPRC
5 integral component of plasma membrane GO:0005887 9.35 CD2 CD33 CD34 KIT PTPRC
6 cytoplasmic side of plasma membrane GO:0009898 9.32 KIT PTPRC
7 external side of plasma membrane GO:0009897 9.02 CD2 CD33 CD34 KIT PTPRC

Biological processes related to Extracutaneous Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.58 CD2 CD33 CD34
2 neutrophil degranulation GO:0043312 9.54 CD33 CD68 PTPRC
3 hemopoiesis GO:0030097 9.32 CD34 KIT
4 positive regulation of tumor necrosis factor production GO:0032760 9.26 CD2 PTPRC
5 T cell activation GO:0042110 9.16 CD2 PTPRC
6 T cell differentiation GO:0030217 8.96 KIT PTPRC
7 heterotypic cell-cell adhesion GO:0034113 8.62 CD2 PTPRC

Sources for Extracutaneous Mastocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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