MCID: EXT007
MIFTS: 41

Extracutaneous Mastocytoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Extracutaneous Mastocytoma

MalaCards integrated aliases for Extracutaneous Mastocytoma:

Name: Extracutaneous Mastocytoma 12 60 15 17 74
Mastocytoma 45 74
Mast Cell Neoplasm 74
Benign Mastocytoma 74

Characteristics:

Orphanet epidemiological data:

60
extracutaneous mastocytoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:4659
MeSH 45 D034801
NCIt 51 C7136
SNOMED-CT 69 63175003
ICD10 34 D47.09
ICD10 via Orphanet 35 C96.2
UMLS via Orphanet 75 C0272202
Orphanet 60 ORPHA66662

Summaries for Extracutaneous Mastocytoma

MalaCards based summary : Extracutaneous Mastocytoma, also known as mastocytoma, is related to cutaneous solitary mastocytoma and mastocytosis, cutaneous. An important gene associated with Extracutaneous Mastocytoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. Affiliated tissues include skin, bone and t cells.

Wikipedia : 77 Extracutaneous mastocytoma presents with benign appearing mast cells occurring in sites other than the... more...

Related Diseases for Extracutaneous Mastocytoma

Diseases related to Extracutaneous Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 cutaneous solitary mastocytoma 33.8 CD2 KIT
2 mastocytosis, cutaneous 33.0 CD2 KIT
3 mastocytosis 30.8 CD2 KIT
4 mast cell neoplasm 30.4 CD2 KIT
5 systemic mastocytosis 30.1 CD2 KIT
6 histiocytoma 29.8 KIT PTPRC
7 leukemia, acute myeloid 28.8 CD2 CD33 CD34 KIT PTPRC
8 cutaneous mastocytoma 12.7
9 benign mastocytoma 12.1
10 mast-cell sarcoma 11.4
11 urticaria 10.3
12 gallbladder leiomyoma 10.2 CD34 KIT
13 leiomyoma 10.2 CD34 KIT
14 lung leiomyosarcoma 10.2 CD34 KIT
15 liver leiomyoma 10.2 CD34 KIT
16 deep leiomyoma 10.2 CD34 KIT
17 mediastinal cancer 10.2 CD33 KIT
18 small intestine leiomyosarcoma 10.2 CD34 KIT
19 small intestinal sarcoma 10.2 CD34 KIT
20 gallbladder sarcoma 10.2 CD34 KIT
21 prostate leiomyosarcoma 10.2 CD34 KIT
22 sm-ahnmd 10.2 CD2 KIT
23 indolent systemic mastocytosis 10.2 CD2 KIT
24 helsmoortel-van der aa syndrome 10.2 CD33 KIT
25 plexiform schwannoma 10.2 CD34 KIT
26 peritoneal benign neoplasm 10.2 CD34 KIT
27 diffuse peritoneal leiomyomatosis 10.2 CD34 KIT
28 breast angiosarcoma 10.2 CD34 KIT
29 senile angioma 10.2 CD34 KIT
30 angiomyoma 10.2 CD34 KIT
31 spindle cell liposarcoma 10.1 CD34 KIT
32 sclerosing cholangitis, neonatal 10.1
33 mesenchymal cell neoplasm 10.1 CD34 KIT
34 cardiovascular organ benign neoplasm 10.1 CD34 KIT
35 benign perivascular tumor 10.1 CD34 KIT
36 endometrial small cell carcinoma 10.1 KIT PTPRC
37 small cell carcinoma 10.1 KIT PTPRC
38 testicular infarct 10.1 KIT PTPRC
39 muscle cancer 10.1 CD34 KIT
40 liver inflammatory pseudotumor 10.1 CD34 PTPRC
41 vascular cancer 10.1 CD34 KIT
42 vulvar sarcoma 10.1 CD34 PTPRC
43 langerhans cell histiocytosis 10.1
44 leukemia 10.1
45 melanoma 10.1
46 histiocytosis 10.1
47 influenza 10.1
48 chronic monocytic leukemia 10.1 CD34 PTPRC
49 neurofibroma 10.1 CD34 KIT
50 myeloid sarcoma 10.0 KIT PTPRC

Graphical network of the top 20 diseases related to Extracutaneous Mastocytoma:



Diseases related to Extracutaneous Mastocytoma

Symptoms & Phenotypes for Extracutaneous Mastocytoma

Drugs & Therapeutics for Extracutaneous Mastocytoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of TF002 in Cutaneous Mastocytosis Completed NCT00457288 Phase 2 TF 002
2 Natural History of Urticaria Pigmentosa in Children Completed NCT00467792
3 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Active, not recruiting NCT02761473
4 Adaptation of the Questionnaire "Regarding Patient's Quality of Life With Mastocytosis" in the French Language Not yet recruiting NCT03632811
5 Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous Catheter Terminated NCT01616537 Not Applicable

Search NIH Clinical Center for Extracutaneous Mastocytoma

Cochrane evidence based reviews: mastocytoma

Genetic Tests for Extracutaneous Mastocytoma

Anatomical Context for Extracutaneous Mastocytoma

MalaCards organs/tissues related to Extracutaneous Mastocytoma:

42
Skin, Bone, T Cells, Bone Marrow, Liver, Spleen, Myeloid

Publications for Extracutaneous Mastocytoma

Articles related to Extracutaneous Mastocytoma:

(show top 50) (show all 539)
# Title Authors Year
1
Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management. ( 30465511 )
2019
2
Cutaneous mastocytoma associated with abundant eosinophil infiltration and flame figures. ( 31034654 )
2019
3
Perioperative anaphylaxis in a patient with a solitary mastocytoma. ( 30854701 )
2019
4
Dermoscopy of Cutaneous Mastocytoma. ( 29854655 )
2018
5
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. ( 28397975 )
2018
6
Pleomorphic mastocytoma in an adult. ( 29148588 )
2018
7
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279. ( 29463690 )
2018
8
Solitary mastocytoma in the eyelid of an adult. ( 29468227 )
2018
9
Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. ( 29710479 )
2018
10
Solitary mastocytoma presenting at birth. ( 29716178 )
2018
11
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma. ( 30356111 )
2018
12
Solitary Mastocytoma of the Eyelid in an Adult Patient With Prolidase Deficiency. ( 25603535 )
2017
13
Rare cause of recurrent urticaria in childhood and its unusual presentation: Solitary mastocytoma on vulva. ( 27206703 )
2017
14
The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma. ( 28580034 )
2017
15
Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma. ( 28918040 )
2017
16
Congenital cutaneous Langerhans cell histiocytosis and cutaneous mastocytoma in a child. ( 27617456 )
2016
17
Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment. ( 27648381 )
2016
18
Solitary mastocytoma with positive Darier's sign. ( 27057508 )
2016
19
Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations. ( 27802814 )
2016
20
Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway. ( 28127293 )
2016
21
Topical corticosteroids versus "wait and see" in the management of solitary mastocytoma in pediatric patients: a long-term follow-up. ( 25471152 )
2015
22
Asymptomatic solitary cutaneous mastocytoma: a rare presentation. ( 25484432 )
2014
23
Identification of KIT activating mutations in paediatric solitary mastocytoma. ( 24128084 )
2014
24
Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells. ( 24249003 )
2014
25
Bioengineering murine mastocytoma cells to produce anticoagulant heparin. ( 24326668 )
2014
26
Intramuscular electroporation of a P1A-encoding plasmid vaccine delays P815 mastocytoma growth. ( 24342164 )
2014
27
Cutaneous mast cell tumor (Mastocytoma): cyto- histopathological and haematological investigations. ( 24444100 )
2014
28
Role of lipid raft components and actin cytoskeleton in fibronectin-binding, surface expression, and de novo synthesis of integrin subunits in PGE2- or 8-Br-cAMP-stimulated mastocytoma P-815 cells. ( 24518258 )
2014
29
Solitary mastocytoma of the vulva. ( 24800094 )
2014
30
Case Report: Solitary mastocytoma treated successfully with topical tacrolimus. ( 25210620 )
2014
31
Solitary mastocytoma mimicking granuloma faciale. ( 25257118 )
2014
32
Solitary mastocytoma with associated pseudocarcinomatous hyperplasia. ( 23252514 )
2013
33
Intratumoural interleukin-2 therapy can induce regression of non-resectable mastocytoma in dogs. ( 23267141 )
2013
34
Behavior of the P1.HTR mastocytoma cell line implanted in the chorioallantoic membrane of chick embryos. ( 23314344 )
2013
35
Solitary mastocytoma of the eyelid. ( 23871296 )
2013
36
Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. ( 24072749 )
2013
37
Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma. ( 22498828 )
2012
38
NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation. ( 22583069 )
2012
39
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. ( 22677519 )
2012
40
Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. ( 22936666 )
2012
41
Dermacase: Can you identify this condition? Solitary mastocytoma. ( 22977914 )
2012
42
Induction of integrin β3 in PGE₂-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin. ( 21276770 )
2011
43
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. ( 21501463 )
2011
44
Solitary mastocytoma with histologic features of eosinophilic cellulites. ( 21540136 )
2011
45
Pathology quiz case 1. Pediatric solitary mastocytoma. ( 21768423 )
2011
46
Solitary mastocytoma in an adult with an unusual clinical presentation. ( 21839341 )
2011
47
A solitary mastocytoma presenting with urticaria and angioedema in a 14-year-old boy. ( 21708063 )
2010
48
A rare presentation of solitary mastocytoma in the palm of an infant. ( 19502121 )
2010
49
Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells. ( 19960020 )
2010
50
Mastocytoma in the common carpal sheath of the digital flexor tendons of a horse. ( 20148821 )
2010

Variations for Extracutaneous Mastocytoma

Expression for Extracutaneous Mastocytoma

Search GEO for disease gene expression data for Extracutaneous Mastocytoma.

Pathways for Extracutaneous Mastocytoma

GO Terms for Extracutaneous Mastocytoma

Cellular components related to Extracutaneous Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.88 CD2 CD33 CD34 CD68 KIT PTPRC
2 plasma membrane GO:0005886 9.73 CD2 CD33 CD34 CD68 KIT PTPRC
3 cell surface GO:0009986 9.46 CD2 CD34 KIT PTPRC
4 cell periphery GO:0071944 9.37 CD34 PTPRC
5 integral component of plasma membrane GO:0005887 9.35 CD2 CD33 CD34 KIT PTPRC
6 cytoplasmic side of plasma membrane GO:0009898 9.32 KIT PTPRC
7 external side of plasma membrane GO:0009897 9.02 CD2 CD33 CD34 KIT PTPRC

Biological processes related to Extracutaneous Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.58 CD2 CD33 CD34
2 neutrophil degranulation GO:0043312 9.54 CD33 CD68 PTPRC
3 hemopoiesis GO:0030097 9.32 CD34 KIT
4 positive regulation of tumor necrosis factor production GO:0032760 9.26 CD2 PTPRC
5 T cell activation GO:0042110 9.16 CD2 PTPRC
6 T cell differentiation GO:0030217 8.96 KIT PTPRC
7 heterotypic cell-cell adhesion GO:0034113 8.62 CD2 PTPRC

Sources for Extracutaneous Mastocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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