MCID: EXT007
MIFTS: 41

Extracutaneous Mastocytoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Extracutaneous Mastocytoma

MalaCards integrated aliases for Extracutaneous Mastocytoma:

Name: Extracutaneous Mastocytoma 12 60 15 17 74
Mastocytoma 45 74
Mast Cell Neoplasm 74
Benign Mastocytoma 74

Characteristics:

Orphanet epidemiological data:

60
extracutaneous mastocytoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:4659
MeSH 45 D034801
NCIt 51 C7136
SNOMED-CT 69 63175003
ICD10 34 D47.09
ICD10 via Orphanet 35 C96.2
UMLS via Orphanet 75 C0272202
Orphanet 60 ORPHA66662

Summaries for Extracutaneous Mastocytoma

MalaCards based summary : Extracutaneous Mastocytoma, also known as mastocytoma, is related to cutaneous solitary mastocytoma and mast cell neoplasm. An important gene associated with Extracutaneous Mastocytoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. Affiliated tissues include skin, bone and bone marrow.

Wikipedia : 77 Extracutaneous mastocytoma presents with benign appearing mast cells occurring in sites other than the... more...

Related Diseases for Extracutaneous Mastocytoma

Diseases related to Extracutaneous Mastocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 cutaneous solitary mastocytoma 33.8 CD2 KIT
2 mast cell neoplasm 33.1 CD2 KIT
3 mastocytosis, cutaneous 32.9 CD2 KIT
4 mastocytosis 30.8 CD2 KIT
5 systemic mastocytosis 30.1 CD2 KIT
6 histiocytoma 29.8 KIT PTPRC
7 cutaneous mastocytoma 12.7
8 benign mastocytoma 12.1
9 mast-cell sarcoma 11.4
10 urticaria 10.2
11 gallbladder leiomyoma 10.2 CD34 KIT
12 leiomyoma 10.2 CD34 KIT
13 lung leiomyosarcoma 10.2 CD34 KIT
14 liver leiomyoma 10.2 CD34 KIT
15 deep leiomyoma 10.2 CD34 KIT
16 mediastinal cancer 10.2 CD33 KIT
17 small intestine leiomyosarcoma 10.2 CD34 KIT
18 small intestinal sarcoma 10.2 CD34 KIT
19 gallbladder sarcoma 10.2 CD34 KIT
20 prostate leiomyosarcoma 10.2 CD34 KIT
21 sm-ahnmd 10.2 CD2 KIT
22 indolent systemic mastocytosis 10.2 CD2 KIT
23 helsmoortel-van der aa syndrome 10.2 CD33 KIT
24 plexiform schwannoma 10.2 CD34 KIT
25 peritoneal benign neoplasm 10.2 CD34 KIT
26 diffuse peritoneal leiomyomatosis 10.2 CD34 KIT
27 breast angiosarcoma 10.2 CD34 KIT
28 senile angioma 10.2 CD34 KIT
29 angiomyoma 10.2 CD34 KIT
30 spindle cell liposarcoma 10.1 CD34 KIT
31 mesenchymal cell neoplasm 10.1 CD34 KIT
32 sclerosing cholangitis, neonatal 10.1
33 cardiovascular organ benign neoplasm 10.1 CD34 KIT
34 benign perivascular tumor 10.1 CD34 KIT
35 endometrial small cell carcinoma 10.1 KIT PTPRC
36 small cell carcinoma 10.1 KIT PTPRC
37 testicular infarct 10.1 KIT PTPRC
38 muscle cancer 10.1 CD34 KIT
39 liver inflammatory pseudotumor 10.1 CD34 PTPRC
40 vascular cancer 10.1 CD34 KIT
41 vulvar sarcoma 10.1 CD34 PTPRC
42 chronic monocytic leukemia 10.0 CD34 PTPRC
43 neurofibroma 10.0 CD34 KIT
44 myeloid sarcoma 10.0 KIT PTPRC
45 langerhans cell histiocytosis 10.0
46 leukemia 10.0
47 melanoma 10.0
48 histiocytosis 10.0
49 influenza 10.0
50 axillary lipoma 10.0 CD68 KIT

Graphical network of the top 20 diseases related to Extracutaneous Mastocytoma:



Diseases related to Extracutaneous Mastocytoma

Symptoms & Phenotypes for Extracutaneous Mastocytoma

Drugs & Therapeutics for Extracutaneous Mastocytoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of TF002 in Cutaneous Mastocytosis Completed NCT00457288 Phase 2 TF 002
2 Natural History of Urticaria Pigmentosa in Children Completed NCT00467792
3 Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations Recruiting NCT02761473
4 Adaptation of the Questionnaire "Regarding Patient's Quality of Life With Mastocytosis" in the French Language Not yet recruiting NCT03632811
5 Evaluation of Patient Satisfaction With and Acceptance of Their Totally-implanted Central Venous Catheter Terminated NCT01616537 Not Applicable

Search NIH Clinical Center for Extracutaneous Mastocytoma

Cochrane evidence based reviews: mastocytoma

Genetic Tests for Extracutaneous Mastocytoma

Anatomical Context for Extracutaneous Mastocytoma

MalaCards organs/tissues related to Extracutaneous Mastocytoma:

42
Skin, Bone, Bone Marrow, T Cells, Spleen, Liver, Lymph Node

Publications for Extracutaneous Mastocytoma

Articles related to Extracutaneous Mastocytoma:

(show top 50) (show all 486)
# Title Authors Year
1
Perioperative anaphylaxis in a patient with a solitary mastocytoma. ( 30854701 )
2019
2
Childhood solitary cutaneous mastocytoma: clinical manifestations, diagnosis, evaluation, and management. ( 30465511 )
2018
3
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. ( 28397975 )
2018
4
Pleomorphic mastocytoma in an adult. ( 29148588 )
2018
5
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279. ( 29463690 )
2018
6
Solitary mastocytoma in the eyelid of an adult. ( 29468227 )
2018
7
Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. ( 29710479 )
2018
8
Solitary mastocytoma presenting at birth. ( 29716178 )
2018
9
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma. ( 30356111 )
2018
10
The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma. ( 28580034 )
2017
11
Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma. ( 28918040 )
2017
12
Solitary mastocytoma with positive Darier's sign. ( 27057508 )
2016
13
Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations. ( 27802814 )
2016
14
Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway. ( 28127293 )
2016
15
Topical corticosteroids versus "wait and see" in the management of solitary mastocytoma in pediatric patients: a long-term follow-up. ( 25471152 )
2015
16
Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells. ( 24249003 )
2014
17
Bioengineering murine mastocytoma cells to produce anticoagulant heparin. ( 24326668 )
2014
18
Intramuscular electroporation of a P1A-encoding plasmid vaccine delays P815 mastocytoma growth. ( 24342164 )
2014
19
Cutaneous mast cell tumor (Mastocytoma): cyto- histopathological and haematological investigations. ( 24444100 )
2014
20
Role of lipid raft components and actin cytoskeleton in fibronectin-binding, surface expression, and de novo synthesis of integrin subunits in PGE2- or 8-Br-cAMP-stimulated mastocytoma P-815 cells. ( 24518258 )
2014
21
Solitary mastocytoma of the vulva. ( 24800094 )
2014
22
Case Report: Solitary mastocytoma treated successfully with topical tacrolimus. ( 25210620 )
2014
23
Solitary mastocytoma mimicking granuloma faciale. ( 25257118 )
2014
24
Solitary mastocytoma with associated pseudocarcinomatous hyperplasia. ( 23252514 )
2013
25
Intratumoural interleukin-2 therapy can induce regression of non-resectable mastocytoma in dogs. ( 23267141 )
2013
26
Behavior of the P1.HTR mastocytoma cell line implanted in the chorioallantoic membrane of chick embryos. ( 23314344 )
2013
27
Solitary mastocytoma of the eyelid. ( 23871296 )
2013
28
Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. ( 24072749 )
2013
29
NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation. ( 22583069 )
2012
30
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. ( 22677519 )
2012
31
Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. ( 22936666 )
2012
32
Dermacase: Can you identify this condition? Solitary mastocytoma. ( 22977914 )
2012
33
Induction of integrin β3 in PGE₂-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin. ( 21276770 )
2011
34
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. ( 21501463 )
2011
35
Solitary mastocytoma with histologic features of eosinophilic cellulites. ( 21540136 )
2011
36
Pathology quiz case 1. Pediatric solitary mastocytoma. ( 21768423 )
2011
37
Solitary mastocytoma in an adult with an unusual clinical presentation. ( 21839341 )
2011
38
A rare presentation of solitary mastocytoma in the palm of an infant. ( 19502121 )
2010
39
Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells. ( 19960020 )
2010
40
Mastocytoma in the common carpal sheath of the digital flexor tendons of a horse. ( 20148821 )
2010
41
Images for diagnosis. A vulva mastocytoma having grown for eighteen years. ( 20193267 )
2010
42
VEGF expression in dog mastocytoma. ( 20509299 )
2010
43
Growth of vascular smooth muscle cells on collagen I exposed to RBL-2H3 mastocytoma cells. ( 20511706 )
2010
44
PUFA-dependent alteration of oxidative parameters of a canine mastocytoma cell line. ( 21087915 )
2010
45
Characterization of an early signaling defect following Fc epsilonRI activation in the canine mastocytoma cell line, C2. ( 19135724 )
2009
46
Anti-cancer effect of two alkaloids: 2R and 2S-bgugaine on mastocytoma P815 and carcinoma Hep. ( 19401921 )
2009
47
Effect of radiation on vascular endothelial growth factor expression in the C2 canine mastocytoma cell line. ( 19719431 )
2009
48
Co-expression of P1A35-43/beta2m fusion protein and co-stimulatory molecule CD80 elicits effective anti-tumor immunity in the P815 mouse mastocytoma tumor model. ( 19787242 )
2009
49
Combined Mastocytoma-hemangioma in a Patient with Urticaria Pigmentosa. ( 27303182 )
2008
50
Adult onset, hypopigmented solitary mastocytoma: report of two cases. ( 18187823 )
2008

Variations for Extracutaneous Mastocytoma

Expression for Extracutaneous Mastocytoma

Search GEO for disease gene expression data for Extracutaneous Mastocytoma.

Pathways for Extracutaneous Mastocytoma

GO Terms for Extracutaneous Mastocytoma

Cellular components related to Extracutaneous Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.88 CD2 CD33 CD34 CD68 KIT PTPRC
2 plasma membrane GO:0005886 9.73 CD2 CD33 CD34 CD68 KIT PTPRC
3 cell surface GO:0009986 9.46 CD2 CD34 KIT PTPRC
4 cell periphery GO:0071944 9.37 CD34 PTPRC
5 integral component of plasma membrane GO:0005887 9.35 CD2 CD33 CD34 KIT PTPRC
6 cytoplasmic side of plasma membrane GO:0009898 9.32 KIT PTPRC
7 external side of plasma membrane GO:0009897 9.02 CD2 CD33 CD34 KIT PTPRC

Biological processes related to Extracutaneous Mastocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.58 CD2 CD33 CD34
2 neutrophil degranulation GO:0043312 9.54 CD33 CD68 PTPRC
3 hemopoiesis GO:0030097 9.32 CD34 KIT
4 positive regulation of tumor necrosis factor production GO:0032760 9.26 CD2 PTPRC
5 T cell activation GO:0042110 9.16 CD2 PTPRC
6 T cell differentiation GO:0030217 8.96 KIT PTPRC
7 heterotypic cell-cell adhesion GO:0034113 8.62 CD2 PTPRC

Sources for Extracutaneous Mastocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....