MCID: EXT025
MIFTS: 37

Extragonadal Germ Cell Cancer

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Extragonadal Germ Cell Cancer

MalaCards integrated aliases for Extragonadal Germ Cell Cancer:

Name: Extragonadal Germ Cell Cancer 12 15
Extragonadal Germ Cell Tumor 53 55 73
Extragonadal Germ Cell Malignant Tumor 12
Neoplasm of Extragonadal Germ Cell 12
Tumor of Extragonadal Germ Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4717
NCIt 50 C3918 C8881

Summaries for Extragonadal Germ Cell Cancer

Disease Ontology : 12 A germ cell cancer that derives from germ cells that are found in areas of the body other than the ovary or testicle. The tumors originate in the sperm forming cells in the testicles or egg producing cells in the ovary.

MalaCards based summary : Extragonadal Germ Cell Cancer, also known as extragonadal germ cell tumor, is related to extragonadal nonseminomatous germ cell tumor and germ cell cancer. An important gene associated with Extragonadal Germ Cell Cancer is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Extragonadal Germ Cell Cancer

Diseases related to Extragonadal Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 extragonadal nonseminomatous germ cell tumor 31.7 AFP G6PC NUTM1 SMUG1
2 germ cell cancer 31.1 AFP POU5F1
3 seminoma 30.2 AFP CGB5 POU5F1
4 testicular cancer 29.9 AFP CGB5
5 mixed extragonadal germ cell cancer 12.4
6 germ cells tumors 10.9
7 hypogonadotropic hypogonadism 10.4
8 testicular microlithiasis 10.2
9 teratoma 10.1 AFP POU5F1
10 brain germinoma 10.1 AFP POU5F1
11 central nervous system germ cell tumor 10.1 AFP POU5F1
12 embryonal testis carcinoma 10.1 AFP POU5F1
13 hepatic adenomas, familial 10.1 AFP G6PC
14 ovarian embryonal carcinoma 10.1 AFP POU5F1
15 embryonal carcinoma 10.1 AFP POU5F1
16 intratubular embryonal carcinoma 10.1 AFP POU5F1
17 malignant teratoma 10.1 AFP POU5F1
18 liver lymphoma 10.1 AFP SMUG1
19 sternum cancer 10.1 AFP SMUG1
20 testicular infarct 10.1 AFP POU5F1
21 embryoma 10.1 AFP POU5F1
22 pineoblastoma 10.1 AFP POU5F1
23 oculomotor nerve paralysis 10.1 AFP SMUG1
24 third cranial nerve disease 10.1 AFP SMUG1
25 mixed germ cell cancer 10.1 AFP POU5F1
26 thrombocytopenia 10.1
27 mixed cell type cancer 10.1 AFP POU5F1
28 mediastinal cancer 10.1 AFP SMUG1
29 renal cell carcinoma, nonpapillary 10.1
30 systemic lupus erythematosus 10.1
31 aspergillosis 10.1
32 leiomyosarcoma 10.1
33 choriocarcinoma 10.1
34 lymphocele 10.1
35 infertility 10.1
36 retroperitoneal leiomyosarcoma 10.1
37 lupus erythematosus 10.1
38 ewing's family of tumors 10.1
39 testicular seminoma 10.1
40 germ cell and embryonal cancer 10.1 AFP POU5F1
41 testicular yolk sac tumor 10.0 AFP POU5F1
42 peliosis hepatis 10.0 AFP SMUG1
43 tracheal cancer 10.0 AFP SMUG1
44 uterine anomalies 10.0 AFP SMUG1
45 nonseminomatous germ cell tumor 10.0 AFP CGB5
46 malignant sertoli cell tumor 10.0 AFP CGB5
47 gastrointestinal system cancer 10.0 AFP SMUG1
48 mature teratoma 9.9 AFP POU5F1 SMUG1
49 endocrine gland cancer 9.9 AFP SMUG1
50 placenta disease 9.9 AFP CGB5

Graphical network of the top 20 diseases related to Extragonadal Germ Cell Cancer:



Diseases related to Extragonadal Germ Cell Cancer

Symptoms & Phenotypes for Extragonadal Germ Cell Cancer

GenomeRNAi Phenotypes related to Extragonadal Germ Cell Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.36 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.36 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.36 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 POU5F1

Drugs & Therapeutics for Extragonadal Germ Cell Cancer

Search Clinical Trials , NIH Clinical Center for Extragonadal Germ Cell Cancer

Genetic Tests for Extragonadal Germ Cell Cancer

Anatomical Context for Extragonadal Germ Cell Cancer

MalaCards organs/tissues related to Extragonadal Germ Cell Cancer:

41
Ovary, Bone, Bone Marrow, Prostate, Brain, Liver, Placenta

Publications for Extragonadal Germ Cell Cancer

Articles related to Extragonadal Germ Cell Cancer:

(show top 50) (show all 58)
# Title Authors Year
1
Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report. ( 29506496 )
2018
2
Hypertestosteronemia and Infertility from a Mediastinal Extragonadal Germ Cell Tumor. ( 28161346 )
2017
3
Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor. ( 27800296 )
2017
4
Testicular Microlithiasis in the Setting of Primary Extragonadal Germ Cell Tumor: A Case Series. ( 27599309 )
2016
5
Recovery from Choriocarcinoma Syndrome Associated with a Metastatic Extragonadal Germ Cell Tumor Hemorrhage. ( 27403124 )
2016
6
Primary extragonadal germ cell tumor: A case report on prostate seminoma. ( 26622843 )
2015
7
Extragonadal germ cell tumor with the "burned-out" phenomenon presented a multiple retroperitoneal masses: a case report. ( 25219912 )
2014
8
Mixed extragonadal germ cell tumor arising from the prostate: a rare combination. ( 24589456 )
2014
9
Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case. ( 23549017 )
2013
10
Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy. ( 25648048 )
2011
11
Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report. ( 20338049 )
2010
12
A rare case of malignant extragonadal germ cell tumor in the pineal region with an aggressive behaviour. ( 19507665 )
2009
13
Metachronous testicular tumor developing eight years after retroperitoneal extragonadal germ cell tumor. ( 18304228 )
2008
14
Leptomeningeal metastases in a patient with an extragonadal germ cell tumor. ( 21892301 )
2008
15
Comparative proteome, transcriptome, and genome analysis of a gonadal and an extragonadal germ cell tumor cell line. ( 18642941 )
2008
16
Temporary effect of arsenic trioxide treatment of refractory extragonadal germ cell cancer. ( 17653913 )
2007
17
Testicular seminoma occurring 8 years after treatment of a metastatic extragonadal germ cell tumor. ( 17199868 )
2007
18
Successful treatment of disseminated extragonadal germ cell cancer with intensive conventional chemotherapy after first-line high-dose chemotherapy. ( 16508731 )
2006
19
Retroperitoneal extragonadal germ cell tumor presenting as a bulky pelvic mass of the obturator fossa. ( 16563147 )
2006
20
Retroperitoneal extragonadal germ cell tumor in a patient with Klinefelter's syndrome. ( 16174054 )
2005
21
Primary extragonadal germ cell tumor of the prostate in a young man. ( 15285762 )
2004
22
Extragonadal germ-cell tumor: a rare differential diagnosis of a cervical lump in a young man. ( 12199179 )
2002
23
Extragonadal germ cell tumor with high serum levels of DU-PAN-2. ( 11743319 )
2002
24
Metastatic urinary bladder tumor from extragonadal germ cell tumor: a case report. ( 12375021 )
2002
25
Pediatric extragonadal germ cell tumor of the scalp. ( 11584421 )
2001
26
Extragonadal germ cell tumor of the prostate. ( 11458083 )
2001
27
Unusual presentations of germ cell tumors. Case 3. Nonseminomatous extragonadal germ cell tumor presenting with pulmonary emboli. ( 11157046 )
2001
28
Retroperitoneal Leiomyosarcoma Associated with an Elevated beta-HCG Serum Level Mimicking Extragonadal Germ Cell Tumor. ( 18521299 )
2000
29
Extragonadal germ cell tumor of mediastinum with high serum level of carcinoembryonic antigen and carbohydrate antigen 19-9. ( 10688012 )
2000
30
[Extragonadal germ cell tumor coexisted with renal cell carcinoma--a case report]. ( 11068428 )
2000
31
[A case of extragonadal germ cell tumor with inferior vena caval tumor thrombus]. ( 10540706 )
1999
32
Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome. ( 10226829 )
1999
33
Successful treatment of metastatic poor risk extragonadal germ cell tumor in a 15-year-old boy. ( 9149757 )
1997
34
A case of extragonadal germ cell tumor with elevated postchemotherapy HCG successfully treated by resection of a solitary metastasis and chronic oral etoposide. ( 8609693 )
1996
35
Extragonadal germ cell tumor followed by metachronous testicular tumor. A case report. ( 8912452 )
1996
36
Suspected extragonadal germ-cell cancer syndrome presenting with an orbital mass and elevation of serum CEA, CA 19-9 and CA50 levels. ( 8804457 )
1995
37
Cryptorchidism and extragonadal germ cell tumor. ( 7571185 )
1995
38
Extragonadal germ cell tumor: a clinical study. ( 8669858 )
1995
39
Retroperitoneal extragonadal germ cell tumor diagnosed by needle aspiration cytology and electron microscopy. ( 7484008 )
1995
40
Extragonadal germ cell tumor of retroperitoneal origin: report of two cases. ( 8126921 )
1994
41
Extragonadal germ cell tumor originating in iliac fossa. ( 8390744 )
1993
42
Maxillary extragonadal germ cell tumor: a case report. ( 7515845 )
1993
43
Metastatic extragonadal germ cell tumor. ( 7521324 )
1993
44
Disseminated aspergillosis after fungemia in a patient with extragonadal germ cell tumor undergoing autologous bone marrow transplantation. ( 1655226 )
1991
45
Karyotyping of a hematologic neoplasia developing shortly after treatment for cerebral extragonadal germ cell tumor. ( 1756483 )
1991
46
[Tumor markers--personal experience. A case of advanced extragonadal germ-cell tumor showing complete remission by high-dose combination chemotherapy with autologous bone marrow transplantation]. ( 1716095 )
1991
47
Extragonadal germ cell tumor invading the prostate. ( 2169421 )
1990
48
Metastatic testicular cancer and extragonadal germ cell tumor presenting with neurological symptoms. ( 2162914 )
1990
49
Extragonadal germ cell tumor in the retrovesical region associated with Klinefelter's syndrome: a case report and review of the literature. ( 2535759 )
1989
50
Poorly differentiated carcinoma or extragonadal germ cell cancer. ( 3032035 )
1987

Variations for Extragonadal Germ Cell Cancer

Expression for Extragonadal Germ Cell Cancer

Search GEO for disease gene expression data for Extragonadal Germ Cell Cancer.

Pathways for Extragonadal Germ Cell Cancer

Pathways related to Extragonadal Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 AFP POU5F1
2 10.27 AFP G6PC

GO Terms for Extragonadal Germ Cell Cancer

Cellular components related to Extragonadal Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of endoplasmic reticulum membrane GO:0030176 8.62 FICD G6PC

Sources for Extragonadal Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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