MCID: EXT025
MIFTS: 31

Extragonadal Germ Cell Cancer

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Extragonadal Germ Cell Cancer

MalaCards integrated aliases for Extragonadal Germ Cell Cancer:

Name: Extragonadal Germ Cell Cancer 12 15
Extragonadal Germ Cell Tumor 20 58 54 70
Extragonadal Germ Cell Malignant Tumor 12
Neoplasm of Extragonadal Germ Cell 12
Tumor of Extragonadal Germ Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4717
NCIt 50 C3918 C8881
Orphanet 58 ORPHA363579
UMLS 70 C0262963 C1334581

Summaries for Extragonadal Germ Cell Cancer

Disease Ontology : 12 A germ cell cancer that derives from germ cells that are found in areas of the body other than the ovary or testicle. The tumors originate in the sperm forming cells in the testicles or egg producing cells in the ovary.

MalaCards based summary : Extragonadal Germ Cell Cancer, also known as extragonadal germ cell tumor, is related to seminoma and endodermal sinus tumor. An important gene associated with Extragonadal Germ Cell Cancer is AFP (Alpha Fetoprotein). The drugs Lenograstim and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone.

Related Diseases for Extragonadal Germ Cell Cancer

Diseases related to Extragonadal Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 seminoma 31.0 CGB5 AFP
2 endodermal sinus tumor 30.6 CGB5 AFP
3 germ cell cancer 30.6 RLN1 ATF7IP AFP
4 nonseminomatous germ cell tumor 30.5 CGB5 AFP
5 teratoma 30.0 CGB5 AFP
6 germinoma 30.0 CGB5 AFP
7 cryptorchidism, unilateral or bilateral 29.9 CGB5 ATF7IP AFP
8 testicular cancer 29.6 CGB5 ATF7IP AFP
9 embryonal carcinoma 29.6 CGB5 AFP
10 mixed extragonadal germ cell cancer 11.4
11 extragonadal nonseminomatous germ cell tumor 11.3
12 choriocarcinoma 10.6
13 testicular yolk sac tumor 10.5
14 hypogonadotropic hypogonadism 10.3
15 adult respiratory distress syndrome 10.2
16 hemopericardium 10.2
17 pericardial effusion 10.2
18 retroperitoneal germ cell neoplasm 10.2
19 hydrocele 10.2
20 mixed germ cell tumor 10.2
21 thrombocytopenia 10.1
22 testicular disease 10.1
23 germ cells tumors 10.1
24 renal cell carcinoma, nonpapillary 10.1
25 systemic lupus erythematosus 10.1
26 thymoma, familial 10.1
27 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.1
28 gallbladder disease 1 10.1
29 testicular microlithiasis 10.1
30 aspergillosis 10.1
31 dermatomyositis 10.1
32 infant gynecomastia 10.1
33 ureteral benign neoplasm 10.1
34 gynecomastia 10.1
35 cholestasis 10.1
36 obstructive jaundice 10.1
37 toxic shock syndrome 10.1
38 vascular disease 10.1
39 pericarditis 10.1
40 leiomyosarcoma 10.1
41 glucosephosphate dehydrogenase deficiency 10.1
42 thymoma 10.1
43 myopathy 10.1
44 uremia 10.1
45 infertility 10.1
46 retroperitoneal leiomyosarcoma 10.1
47 extragonadal seminoma 10.1
48 in situ carcinoma 10.1
49 lupus erythematosus 10.1
50 soft tissue sarcoma 10.1

Graphical network of the top 20 diseases related to Extragonadal Germ Cell Cancer:



Diseases related to Extragonadal Germ Cell Cancer

Symptoms & Phenotypes for Extragonadal Germ Cell Cancer

Drugs & Therapeutics for Extragonadal Germ Cell Cancer

Drugs for Extragonadal Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Ofloxacin Approved Phase 3 82419-36-1 4583
6
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
7
Etoposide Approved Phase 3 33419-42-0 36462
8
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
9
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599 43805
10
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
11
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
12
Ifosfamide Approved Phase 3 3778-73-2 3690
13
Vinblastine Approved Phase 3 865-21-4 13342 241903
14 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
15 Cola Phase 3
16 Narcotics Phase 3
17 Anesthetics Phase 3
18 Anesthetics, Intravenous Phase 3
19 Anesthetics, General Phase 3
20 Analgesics, Opioid Phase 3
21 Analgesics Phase 3
22 Antirheumatic Agents Phase 3
23 Immunosuppressive Agents Phase 3
24 Immunologic Factors Phase 3
25 Anti-Infective Agents Phase 3
26 Cytochrome P-450 Enzyme Inhibitors Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Etoposide phosphate Phase 3
29 Anti-Bacterial Agents Phase 3
30 Tubulin Modulators Phase 3
31 Antimitotic Agents Phase 3
32 Alkylating Agents Phase 3
33 Albumin-Bound Paclitaxel Phase 3
34
Isophosphamide mustard Phase 3 100427
35
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
36
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
37
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
38
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
39
leucovorin Approved Phase 2 58-05-9 6006
40
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
41
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
42
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
43
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
44
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
45
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
46
Epirubicin Approved Phase 2 56420-45-2 41867
47
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
48
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
49 Liver Extracts Phase 2
50 Protective Agents Phase 2

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
4 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
5 INTERNATIONAL RANDOMIZED STUDY FOR THE SALVAGE TREATMENT OF GERM CELL TUMOURS Completed NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
6 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
7 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
8 Phase II Study Of Arsenic Trioxide In Patients With Refractory Germ Cell Malignancies Completed NCT00036842 Phase 2 arsenic trioxide
9 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
10 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
11 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
12 INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
13 Phase II Pre-Irradiation Chemotherapy for Central Nervous System Germ Cell Malignancies Completed NCT00002472 Phase 2 cisplatin;etoposide
14 High Dose Ifosfamide, Carboplatin and Etoposide With Amifostine Chemoprotection Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
15 PROTOCOL FOR THE TREATMENT OF MALIGNANT NON-TESTICULAR GERM CELL TUMORS Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
16 PHASE I/II TRIAL OF SEQUENTIAL TAXOL/IFOSFAMIDE AND DOSEINTENSIVE CARBOPLATIN/ETOPOSIDE WITH STEM CELL SUPPORT IN CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH UNFAVORABLE PROGNOSTIC FEATURES Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
17 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
18 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
19 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
20 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
21 Phase II Study of Intensive Chemotherapy With Autologous Peripheral Blood Stem Cell Support in Patients With Cisplatin Resistant Germ Cell Tumors Terminated NCT00003852 Phase 2 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;paclitaxel;thiotepa
22 Phase I of Intrathecal Melphalan in Patients With Recurrent Neoplastic Meningitis Completed NCT00002750 Phase 1 melphalan
23 TREATMENT OF CHILDREN AND YOUNG ADULTS WITH RECURRENT/REFRACTORY SOLID TUMORS WITH HIGH DOSE ETOPOSIDE AND CARBOPLATIN PLUS ESCALATING DOSE CYCLOPHOSPHAMIDE, FOLLOWED BY HEMATOPOIETIC RESCUE USING AUTOLOGOUS CD34+ SELECTED BLOOD STEM CELLS: A PILOT STUDY Completed NCT00007813 Phase 1 carboplatin;cyclophosphamide;etoposide
24 A Phase I Study of Intraperitoneal Oxaliplatin Alone and in Combination With Intraperitoneal Floxuridine and Leucovorin in Patients With Advanced Metastatic Cancer Confined to the Peritoneal Cavity Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
25 A Phase I Study of Thrombopoietin (rhTPO) Plus G-CSF in Children Receiving Ifosfamide, Carboplatin, and Etoposide (I.C.E.) Chemotherapy for Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
26 A Phase I Study of the Chemoprotectant Amifostine With Autologous Stem Cell Transplantation for High Risk or Relapsed Pediatric Solid Tumors and Brain Tumors Terminated NCT00003926 Phase 1 amifostine trihydrate;busulfan;filgrastim;melphalan;thiotepa
27 Barriers to Patient Enrollment Onto Frontline Therapeutic Clinical Trials and Development of Intervention Strategies to Increase the Proportion of Enrollment Completed NCT00002485

Search NIH Clinical Center for Extragonadal Germ Cell Cancer

Genetic Tests for Extragonadal Germ Cell Cancer

Anatomical Context for Extragonadal Germ Cell Cancer

MalaCards organs/tissues related to Extragonadal Germ Cell Cancer:

40
Ovary, Bone Marrow, Bone, Testis, Prostate, Spinal Cord, Liver

Publications for Extragonadal Germ Cell Cancer

Articles related to Extragonadal Germ Cell Cancer:

(show top 50) (show all 171)
# Title Authors PMID Year
1
A case of extragonadal germ cell tumor with elevated postchemotherapy HCG successfully treated by resection of a solitary metastasis and chronic oral etoposide. 61 54
8609693 1996
2
Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report. 61
33541424 2021
3
[Pathological features of primary extragonadal germ cell tumor of the prostate with small round blue cell morphology]. 61
33535304 2021
4
Mediastinal Germ Cell Tumor with Testicular Microlithiasis. 61
33614354 2021
5
[A Case of Extragonadal Germ Cell Tumor Treated by Induction Therapy with A Reduced Bep Regimen]. 61
33435656 2020
6
An extragonadal germ cell tumor with dermatomyositis: A case report and literature review. 61
32953114 2020
7
[A Case of Metachronous Testicular Tumor Developing Twenty Years after Treatment of Retroperitoneal Extragonadal Germ Cell Tumor]. 61
32605355 2020
8
Incidentally discovered primary mediastinal germ cell tumor. 61
32217905 2020
9
Nonseminomatous Extragonadal Germ Cell Tumor Presenting As Early Pericardial Tamponade. 61
32257676 2020
10
Retroperitoneal extragonadal germ cell tumor without distant metastasis: a case report. 61
31950009 2020
11
Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017. 61
30903638 2019
12
Case of acute respiratory distress syndrome in a patient with an extragonadal germ cell tumor without lung metastasis in which choriocarcinoma syndrome was suspected. 61
32743415 2019
13
Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report. 61
30885154 2019
14
A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. 61
31916730 2019
15
Playing the long surveillance ball game: Metachronous testicular tumor developing after treatment and remission of extragonadal germ cell tumor. 61
31523412 2019
16
Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients. 61
29752743 2018
17
Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report. 61
29506496 2018
18
[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR]. 61
30662051 2018
19
Hypertestosteronemia and Infertility from a Mediastinal Extragonadal Germ Cell Tumor. 61
28161346 2017
20
Primary Choriocarcinoma of the Bladder: A Case Report and Review of Literature. 61
27793609 2017
21
Testicular Microlithiasis in the Setting of Primary Extragonadal Germ Cell Tumor: A Case Series. 61
27599309 2017
22
Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor. 61
27800296 2017
23
Dislodgement and gastrointestinal tract penetration of bone cement used for spinal reconstruction after lumbosacral vertebral tumor excision: A case report. 61
27759653 2016
24
Desperation surgery for a chemorefractory lung lesion in a patient with an extragonadal germ cell tumor. 61
31149445 2016
25
Modified Facial Translocation Approach in a One-Month Old With a Skullbase Tumor. 61
27092923 2016
26
Recovery from Choriocarcinoma Syndrome Associated with a Metastatic Extragonadal Germ Cell Tumor Hemorrhage. 61
27403124 2016
27
A clinicopathological study of mediastinal masses operated in a tertiary care hospital in Eastern India in 3 years with special reference to thymoma. 61
26960629 2016
28
Primary extragonadal germ cell tumor: A case report on prostate seminoma. 61
26622843 2015
29
[PRIMARY MEDIASTINAL GERM CELL TUMOR ARISING IN A PATIENT WITH NEUROFIBROMATOSIS TYPE 1]. 61
26419075 2015
30
[A case of metachronal testicular tumor eight years after medical treatment of extragonadal germ cell tumor]. 61
26037678 2015
31
Extragonadal germ cell tumor with the "burned-out" phenomenon presented a multiple retroperitoneal masses: a case report. 61
25219912 2015
32
Mixed extragonadal germ cell tumor arising from the prostate: a rare combination. 61
24589456 2014
33
[A case of primary unknown cancer difficult to distinguish from lung cancer]. 61
24917010 2014
34
Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor. 61
24831771 2014
35
Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. 61
24057924 2013
36
[A suspected case of extra-gonadal germ cell tumor complicated with choriocarcinoma syndrome]. 61
23719141 2013
37
[Endocrine abnormalities in a young patient with metastatic cancer - case 3/2013]. 61
23625630 2013
38
Should extragonadal germ cell tumors be included in studies of families with testicular germ cell tumors? 61
23510634 2013
39
[Testicular tumor arising in intra-abdominal testis which was not detected at prior orchidopexy : a case report]. 61
23633636 2013
40
Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. 61
23374840 2013
41
Primitive neuroectodermal tumor (PNET) as somatic-type malignancy arising from an extragonadal germ-cell tumor: clinical, pathological and molecular features of a case. 61
23549017 2013
42
Probability of metachronous testicular cancer in patients with biopsy-proven intratubular germ cell neoplasia depends on first-time treatment of germ cell cancer. 61
23071246 2012
43
The incidence and management of metachronous testicular germ cell tumors in patients with extragonadal germ cell tumors. 61
20471872 2012
44
Burden of testicular, paratesticular and extragonadal germ cell tumours in Europe. 61
22142457 2012
45
Treatment options for carcinoma in situ testis. 61
21651575 2011
46
Cancer of unknown primary patients with midline nodal distribution: midway between poor and favourable prognosis? 61
20673701 2011
47
Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy. 61
25648048 2011
48
Video-assisted thoracoscopic surgery for a cystic seminoma of the mediastinum. 61
21095363 2010
49
Retroperitoneal germ cell tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration. 61
21191538 2010
50
[Posthepatic obstructive jaundice caused by primary extragonadal germ-cell tumor in a patient with glucose-6-phosphatase dehydrogenase deficiency]. 61
20979002 2010

Variations for Extragonadal Germ Cell Cancer

Expression for Extragonadal Germ Cell Cancer

Search GEO for disease gene expression data for Extragonadal Germ Cell Cancer.

Pathways for Extragonadal Germ Cell Cancer

GO Terms for Extragonadal Germ Cell Cancer

Molecular functions related to Extragonadal Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 RLN1 CGB5

Sources for Extragonadal Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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