MCID: EXT053
MIFTS: 20

Extragonadal Nonseminomatous Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Extragonadal Nonseminomatous Germ Cell Tumor

MalaCards integrated aliases for Extragonadal Nonseminomatous Germ Cell Tumor:

Name: Extragonadal Nonseminomatous Germ Cell Tumor 12 15
Malignant Extragonadal Non-Seminomatous Germ Cell Tumor 73
Primary Malignant Extragonadal Nonseminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5677
NCIt 50 C8885
UMLS 73 C1334582

Summaries for Extragonadal Nonseminomatous Germ Cell Tumor

Disease Ontology : 12 An extragonadal germ cell cancer that are located in the pineal gland in the brain, located in the mediastinum or located in the abdomen.

MalaCards based summary : Extragonadal Nonseminomatous Germ Cell Tumor, also known as malignant extragonadal non-seminomatous germ cell tumor, is related to germ cells tumors and nonseminomatous germ cell tumor. An important gene associated with Extragonadal Nonseminomatous Germ Cell Tumor is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Paclitaxel and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and liver, and related phenotype is neoplasm.

Related Diseases for Extragonadal Nonseminomatous Germ Cell Tumor

Graphical network of the top 20 diseases related to Extragonadal Nonseminomatous Germ Cell Tumor:



Diseases related to Extragonadal Nonseminomatous Germ Cell Tumor

Symptoms & Phenotypes for Extragonadal Nonseminomatous Germ Cell Tumor

MGI Mouse Phenotypes related to Extragonadal Nonseminomatous Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 AFP G6PC SMUG1

Drugs & Therapeutics for Extragonadal Nonseminomatous Germ Cell Tumor

Drugs for Extragonadal Nonseminomatous Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
2
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
3
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 43805 6857599 5310940 9887054
4
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
5
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
6
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
7
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
8
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 1 135968-09-1
9
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11
Vinblastine Approved Phase 3 865-21-4 241903 13342
12
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
13 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
16 Anti-Bacterial Agents Phase 3,Phase 2
17 Alkylating Agents Phase 3,Phase 2,Phase 1
18 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
19 Antibiotics, Antitubercular Phase 3,Phase 2
20 Etoposide phosphate Phase 3,Phase 2
21 Antimitotic Agents Phase 3,Phase 2,Phase 1
22 Gastrointestinal Agents Phase 3,Phase 2
23 Serotonin Agents Phase 3
24 Anti-Allergic Agents Phase 3
25 Serotonin Antagonists Phase 3
26 Histamine H1 Antagonists Phase 3
27
Histamine Phosphate Phase 3 51-74-1 65513
28 Antipruritics Phase 3
29 Neurotransmitter Agents Phase 3
30 Dermatologic Agents Phase 3
31 Histamine Antagonists Phase 3
32
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
33
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
34
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2,Phase 1 1177-87-3
35
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
36
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
37
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
38
Mesna Approved, Investigational Phase 1, Phase 2,Phase 2 3375-50-6 598
39
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
40
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
41
Ranitidine Approved Phase 1, Phase 2 66357-35-5, 66357-59-3 3001055
42
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
43
leucovorin Approved Phase 2 58-05-9 6006 143
44
Fluorouracil Approved Phase 2 51-21-8 3385
45
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
46
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
47
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5330286 5005498
48
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
50
Alvocidib Experimental, Investigational Phase 2 131740-09-5, 146426-40-6 5287969

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
2 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
3 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
4 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
5 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
6 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
7 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
8 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
11 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
12 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
13 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
14 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
15 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
16 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
17 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
18 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
19 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride

Search NIH Clinical Center for Extragonadal Nonseminomatous Germ Cell Tumor

Genetic Tests for Extragonadal Nonseminomatous Germ Cell Tumor

Anatomical Context for Extragonadal Nonseminomatous Germ Cell Tumor

MalaCards organs/tissues related to Extragonadal Nonseminomatous Germ Cell Tumor:

41
Pineal, Brain, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Extragonadal Nonseminomatous Germ Cell Tumor:

19
The Pineal Gl, The Mediastinum Or

Publications for Extragonadal Nonseminomatous Germ Cell Tumor

Articles related to Extragonadal Nonseminomatous Germ Cell Tumor:

# Title Authors Year
1
Retroperitoneal extragonadal nonseminomatous germ cell tumor with synchronous orbital metastasis. ( 19197374 )
2009

Variations for Extragonadal Nonseminomatous Germ Cell Tumor

Expression for Extragonadal Nonseminomatous Germ Cell Tumor

Search GEO for disease gene expression data for Extragonadal Nonseminomatous Germ Cell Tumor.

Pathways for Extragonadal Nonseminomatous Germ Cell Tumor

Pathways related to Extragonadal Nonseminomatous Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 AFP G6PC

GO Terms for Extragonadal Nonseminomatous Germ Cell Tumor

Sources for Extragonadal Nonseminomatous Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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