MCID: EXT053
MIFTS: 26

Extragonadal Nonseminomatous Germ Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Extragonadal Nonseminomatous Germ Cell Tumor

MalaCards integrated aliases for Extragonadal Nonseminomatous Germ Cell Tumor:

Name: Extragonadal Nonseminomatous Germ Cell Tumor 12 15
Malignant Extragonadal Non-Seminomatous Germ Cell Tumor 73
Primary Malignant Extragonadal Nonseminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5677
NCIt 50 C8885
UMLS 73 C1334582

Summaries for Extragonadal Nonseminomatous Germ Cell Tumor

Disease Ontology : 12 An extragonadal germ cell cancer that are located in the pineal gland in the brain, located in the mediastinum or located in the abdomen.

MalaCards based summary : Extragonadal Nonseminomatous Germ Cell Tumor, also known as malignant extragonadal non-seminomatous germ cell tumor, is related to germ cells tumors and nonseminomatous germ cell tumor. An important gene associated with Extragonadal Nonseminomatous Germ Cell Tumor is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include the pineal gl, the mediastinum or and pineal, and related phenotype is neoplasm.

Related Diseases for Extragonadal Nonseminomatous Germ Cell Tumor

Diseases related to Extragonadal Nonseminomatous Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 germ cells tumors 10.3
2 nonseminomatous germ cell tumor 10.3
3 hepatic adenomas, familial 9.8 AFP G6PC
4 extragonadal seminoma 9.7 AFP NUTM1
5 liver lymphoma 9.6 AFP SMUG1
6 sternum cancer 9.6 AFP SMUG1
7 corpus luteum cyst 9.5 AFP SMUG1
8 oculomotor nerve paralysis 9.5 AFP SMUG1
9 third cranial nerve disease 9.5 AFP SMUG1
10 endometrial small cell carcinoma 9.5 AFP SMUG1
11 scrotal carcinoma 9.4 AFP SMUG1
12 mediastinal cancer 9.4 AFP SMUG1
13 mature teratoma 9.4 AFP SMUG1
14 peliosis hepatis 9.2 AFP SMUG1
15 cell type cancer 9.1 AFP SMUG1
16 gastrointestinal system cancer 8.9 AFP SMUG1
17 extragonadal germ cell cancer 8.3 AFP G6PC NUTM1 SMUG1

Graphical network of the top 20 diseases related to Extragonadal Nonseminomatous Germ Cell Tumor:



Diseases related to Extragonadal Nonseminomatous Germ Cell Tumor

Symptoms & Phenotypes for Extragonadal Nonseminomatous Germ Cell Tumor

MGI Mouse Phenotypes related to Extragonadal Nonseminomatous Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 AFP G6PC SMUG1

Drugs & Therapeutics for Extragonadal Nonseminomatous Germ Cell Tumor

Drugs for Extragonadal Nonseminomatous Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 1 135968-09-1
2
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
8
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
9
Vinblastine Approved Phase 3 865-21-4 13342 241903
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
13 Alkylating Agents Phase 3,Phase 2,Phase 1
14 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
15 Gastrointestinal Agents Phase 3,Phase 2
16 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
17 Anti-Bacterial Agents Phase 3,Phase 2
18 Antibiotics, Antitubercular Phase 3,Phase 2
19 Etoposide phosphate Phase 3,Phase 2
20 Antimitotic Agents Phase 3,Phase 2,Phase 1
21 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
22 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
23
Histamine Phosphate Phase 3 51-74-1 65513
24 Serotonin Agents Phase 3
25 Serotonin Antagonists Phase 3
26 Neurotransmitter Agents Phase 3
27 Histamine Antagonists Phase 3
28 Histamine H1 Antagonists Phase 3
29 Dermatologic Agents Phase 3
30 Anti-Allergic Agents Phase 3
31 Antipruritics Phase 3
32
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
33
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
34
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
35
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
36
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
37
Mesna Approved, Investigational Phase 1, Phase 2,Phase 2 3375-50-6 598
38
Ranitidine Approved Phase 1, Phase 2 66357-59-3, 66357-35-5 3001055
39
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
40
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
41
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
42
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
43
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
44
Fluorouracil Approved Phase 2 51-21-8 3385
45
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
46
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
47
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
49
Alvocidib Experimental, Investigational Phase 2 146426-40-6, 131740-09-5 5287969
50 Ranitidine bismuth citrate Phase 1, Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
2 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
3 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
4 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
5 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
6 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
7 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
8 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
9 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
10 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
11 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
12 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
13 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
14 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
15 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
16 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
17 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
18 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
19 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride

Search NIH Clinical Center for Extragonadal Nonseminomatous Germ Cell Tumor

Genetic Tests for Extragonadal Nonseminomatous Germ Cell Tumor

Anatomical Context for Extragonadal Nonseminomatous Germ Cell Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Extragonadal Nonseminomatous Germ Cell Tumor:

19
The Pineal Gl, The Mediastinum Or

MalaCards organs/tissues related to Extragonadal Nonseminomatous Germ Cell Tumor:

41
Pineal, Brain, Bone

Publications for Extragonadal Nonseminomatous Germ Cell Tumor

Articles related to Extragonadal Nonseminomatous Germ Cell Tumor:

# Title Authors Year
1
Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. ( 22763659 )
2013
2
Retroperitoneal extragonadal nonseminomatous germ cell tumor with synchronous orbital metastasis. ( 19197374 )
2009

Variations for Extragonadal Nonseminomatous Germ Cell Tumor

Expression for Extragonadal Nonseminomatous Germ Cell Tumor

Search GEO for disease gene expression data for Extragonadal Nonseminomatous Germ Cell Tumor.

Pathways for Extragonadal Nonseminomatous Germ Cell Tumor

Pathways related to Extragonadal Nonseminomatous Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 AFP G6PC

GO Terms for Extragonadal Nonseminomatous Germ Cell Tumor

Sources for Extragonadal Nonseminomatous Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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