MCID: EXT001
MIFTS: 36

Extragonadal Seminoma

Categories: Cancer diseases

Aliases & Classifications for Extragonadal Seminoma

MalaCards integrated aliases for Extragonadal Seminoma:

Name: Extragonadal Seminoma 12 15 74
Primary Extragonadal Seminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5838
NCIt 51 C7327
UMLS 74 C1333502

Summaries for Extragonadal Seminoma

MalaCards based summary : Extragonadal Seminoma, also known as primary extragonadal seminoma, is related to seminoma and mixed germ cell tumor. An important gene associated with Extragonadal Seminoma is LRRC4C (Leucine Rich Repeat Containing 4C), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Wnt Signaling Pathway and Pluripotency. The drugs Paclitaxel and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lymph node, and related phenotype is embryo.

Related Diseases for Extragonadal Seminoma

Diseases related to Extragonadal Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 seminoma 30.6 AFP KIT POU5F1 TNFRSF8
2 mixed germ cell tumor 10.4 AFP KIT
3 hepatic angiomyolipoma 10.4 AFP KIT
4 ovarian germ cell cancer 10.3 AFP SALL4
5 spermatocytoma 10.3 KIT SALL4
6 brain germinoma 10.3 AFP POU5F1
7 endometrial small cell carcinoma 10.3 AFP KIT
8 mediastinal cancer 10.3 AFP KIT
9 embryonal testis carcinoma 10.3 AFP POU5F1
10 helsmoortel-van der aa syndrome 10.3 KIT SALL4
11 liver leiomyoma 10.3 CEACAM5 KIT
12 fox-fordyce disease 10.2 CEACAM5 KIT
13 mature teratoma 10.2 AFP POU5F1
14 mucinous adenofibroma 10.2 CEACAM5 SEM1
15 ovarian endodermal sinus tumor 10.2 AFP SALL4
16 mucinous cystadenofibroma 10.2 AFP CEACAM5
17 liver lymphoma 10.2 AFP CEACAM5
18 extragonadal nonseminomatous germ cell tumor 10.2 AFP NUTM1
19 endodermal sinus tumor 10.2 AFP SALL4
20 melanotic medulloblastoma 10.2 AFP CEACAM5
21 urachal adenocarcinoma 10.2 AFP CEACAM5
22 mixed germ cell-sex cord neoplasm 10.2 KIT POU5F1 SALL4
23 adenoid basal cell carcinoma 10.2 CEACAM5 KIT
24 hematocele of tunica vaginalis testis 10.2 AFP CEACAM5
25 aggressive digital papillary adenocarcinoma 10.2 CEACAM5 KIT
26 functional colonic disease 10.2 BRD4 KIT
27 malignant teratoma 10.2 AFP POU5F1 SALL4
28 bile duct cystadenocarcinoma 10.2 AFP CEACAM5
29 pineoblastoma 10.2 AFP POU5F1
30 non-functioning pancreatic endocrine tumor 10.2 POU5F1 SOX17 SOX2
31 testicular leukemia 10.1 POU5F1 TFAP2C
32 liver sarcoma 10.1 AFP CEACAM5
33 warthin tumor 10.1 CEACAM5 KIT
34 orbital cyst 10.1 CEACAM5 SOX2
35 central nervous system germ cell tumor 10.1 AFP POU5F1 SOX2
36 atypical follicular adenoma 10.1 CALCA CEACAM5
37 mixed germ cell cancer 10.1 AFP POU5F1
38 rete testis adenocarcinoma 10.1 AFP CEACAM5 KIT
39 rete testis neoplasm 10.1 AFP CEACAM5 KIT
40 fetal adenoma 10.1 CALCA CEACAM5
41 gastrointestinal system cancer 10.1 AFP CEACAM5 KIT
42 scleroderma, familial progressive 10.1
43 hydronephrosis 10.1
44 papillary carcinoma 10.1
45 testicular seminoma 10.1
46 ovarian solid teratoma 10.1 AFP TNFRSF8
47 ovarian primitive germ cell tumor 10.1 AFP SALL4
48 extragonadal germ cell cancer 10.0 AFP NUTM1 POU5F1
49 sternum cancer 10.0 AFP TNFRSF8
50 gastrointestinal system disease 10.0 AFP CEACAM5 KIT

Graphical network of the top 20 diseases related to Extragonadal Seminoma:



Diseases related to Extragonadal Seminoma

Symptoms & Phenotypes for Extragonadal Seminoma

MGI Mouse Phenotypes related to Extragonadal Seminoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.17 KIT NANOG POU5F1 SALL4 SOX17 SOX2

Drugs & Therapeutics for Extragonadal Seminoma

Drugs for Extragonadal Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
3
Bleomycin Approved, Investigational Phase 2, Phase 3 11056-06-7 5360373
4
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 441203 84093 2767
5
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
8
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
9
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 38904 10339178 498142
10
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
11
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
14
Vinblastine Approved Phase 3 865-21-4 13342 241903
15 Anti-Bacterial Agents Phase 2, Phase 3
16 Etoposide phosphate Phase 2, Phase 3,Phase 3
17 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
18 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
19 Antibiotics, Antitubercular Phase 2, Phase 3
20 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
21 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
22 Alkylating Agents Phase 3,Phase 2,Phase 1
23 Immunologic Factors Phase 3,Phase 1,Phase 2
24 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
25 BB 1101 Phase 3,Phase 2,Phase 1
26 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
27
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
28 Histamine H2 Antagonists Phase 3
29
Ranitidine Approved Phase 1, Phase 2 66357-59-3, 66357-35-5 3001055
30
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
31
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
32
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
33
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
34
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
35
leucovorin Approved Phase 2 58-05-9 6006 143
36
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 6857599 5310940 9887054 43805
37
Fluorouracil Approved Phase 2 51-21-8 3385
38
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
39
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
40
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
41
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
43
Alvocidib Experimental, Investigational Phase 2 146426-40-6, 131740-09-5 5287969
44 Gastrointestinal Agents Phase 2
45 glucocorticoids Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
47 Antineoplastic Agents, Hormonal Phase 2
48 Hormone Antagonists Phase 2
49 Antiemetics Phase 2
50 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
3 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
4 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
5 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
6 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
7 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
10 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
11 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
12 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
13 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
14 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
15 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
16 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel

Search NIH Clinical Center for Extragonadal Seminoma

Genetic Tests for Extragonadal Seminoma

Anatomical Context for Extragonadal Seminoma

MalaCards organs/tissues related to Extragonadal Seminoma:

42
Bone, Kidney, Lymph Node, Pancreas, Prostate, Thyroid

Publications for Extragonadal Seminoma

Articles related to Extragonadal Seminoma:

(show all 17)
# Title Authors Year
1
Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report. ( 30069432 )
2018
2
Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma. ( 30263965 )
2018
3
Rapidly Progressive Systemic Sclerosis in a Patient With Suspected Extragonadal Seminoma. ( 26398473 )
2015
4
Endoscopic ultrasound and fine needle aspiration for the diagnosis of extragonadal seminoma metastatic to the pancreas. ( 25409049 )
2014
5
A rare association of extragonadal seminoma with synchronous papillary carcinoma of the thyroid. ( 24626380 )
2014
6
Extragonadal seminoma presenting as a large mass in the pelvic cavity without c-kit-activating mutations. ( 22581924 )
2012
7
Mediastinal extragonadal seminoma presenting as severe back pain in a young male. ( 22073516 )
2011
8
A case of primary extragonadal seminoma arising in the perineum. ( 16679842 )
2006
9
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. ( 11917946 )
2001
10
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. ( 11283942 )
2001
11
Metastatic extragonadal seminoma associated with cardiac transplantation. ( 10942066 )
2000
12
Extragonadal seminoma involving urinary bladder and arising in the prostate. ( 8508362 )
1993
13
Sonographic diagnosis of testicular seminoma occurring 8 years after initial extragonadal seminoma. ( 1942238 )
1991
14
Cis-platinum therapy in a patient with extragonadal seminoma and hydronephrosis of the only functioning kidney. A case report. ( 2424104 )
1986
15
The treatment of extragonadal seminoma. ( 6204019 )
1984
16
Complete remission in extragonadal seminoma primarily treated with chemotherapy and restaged by retroperitoneal nodal dissection. ( 6192802 )
1983
17
Elevated serum calcitonin associated with an extragonadal seminoma. ( 7109118 )
1982

Variations for Extragonadal Seminoma

Expression for Extragonadal Seminoma

Search GEO for disease gene expression data for Extragonadal Seminoma.

Pathways for Extragonadal Seminoma

GO Terms for Extragonadal Seminoma

Cellular components related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear transcription factor complex GO:0044798 8.62 SOX17 SOX2

Biological processes related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.77 POU5F1 SALL4 SOX17 SOX2 TFAP2C
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.7 BRD4 NANOG POU5F1 SALL4 SOX17 SOX2
3 stem cell population maintenance GO:0019827 9.43 KIT NANOG SALL4
4 stem cell differentiation GO:0048863 9.4 KIT SOX17
5 mRNA transcription by RNA polymerase II GO:0042789 9.32 POU5F1 SOX17
6 endodermal cell fate specification GO:0001714 9.13 NANOG POU5F1 SOX2
7 somatic stem cell population maintenance GO:0035019 9.02 KIT NANOG POU5F1 SALL4 SOX2

Molecular functions related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 AFP BRD4 CALCA KIT LRRC4C NANOG
2 miRNA binding GO:0035198 8.96 POU5F1 SOX2

Sources for Extragonadal Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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