MCID: EXT001
MIFTS: 26

Extragonadal Seminoma

Categories: Cancer diseases

Aliases & Classifications for Extragonadal Seminoma

MalaCards integrated aliases for Extragonadal Seminoma:

Name: Extragonadal Seminoma 12 15 70
Primary Extragonadal Seminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5838
NCIt 50 C7327
UMLS 70 C1333502

Summaries for Extragonadal Seminoma

MalaCards based summary : Extragonadal Seminoma, also known as primary extragonadal seminoma, is related to seminoma and testicular seminoma. An important gene associated with Extragonadal Seminoma is TFAP2C (Transcription Factor AP-2 Gamma), and among its related pathways/superpathways is Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Levoleucovorin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include liver, testis and lymph node.

Related Diseases for Extragonadal Seminoma

Diseases related to Extragonadal Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 seminoma 31.1 KIT AFP
2 testicular seminoma 10.1
3 teratoma 10.1 KIT AFP
4 mediastinum seminoma 10.1 KIT AFP
5 mixed germ cell tumor 10.1 KIT AFP
6 extragonadal nonseminomatous germ cell tumor 10.1 NUTM1 AFP
7 pineal region teratoma 10.0 KIT AFP
8 gallbladder leiomyosarcoma 10.0 KIT AFP
9 liver leiomyoma 10.0 KIT AFP
10 pediatric germ cell cancer 10.0 TFAP2C AFP
11 intratubular embryonal carcinoma 10.0 KIT AFP
12 esophageal adenoid cystic carcinoma 10.0 KIT AFP
13 ovarian mixed germ cell neoplasm 10.0 KIT AFP
14 lymphoepithelioma-like thymic carcinoma 10.0 NUTM1 KIT
15 sarcomatous intrahepatic cholangiocarcinoma 10.0 KIT AFP
16 endometrial small cell carcinoma 10.0 KIT AFP
17 dysgerminoma of ovary 10.0 KIT AFP
18 ovarian gonadoblastoma 10.0 KIT AFP
19 scleroderma, familial progressive 10.0
20 testicular microlithiasis 10.0
21 hydronephrosis 10.0
22 penile benign neoplasm 10.0
23 dilated cardiomyopathy 10.0
24 papillary carcinoma 10.0
25 liver cirrhosis 10.0
26 germ cells tumors 10.0
27 back pain 10.0
28 rare tumor 10.0
29 thyroid carcinoma 10.0
30 liver leiomyosarcoma 10.0 KIT AFP
31 seminal vesicle adenocarcinoma 10.0 KIT AFP
32 thymus clear cell carcinoma 9.9 NUTM1 KIT
33 mixed cell type cancer 9.9 KIT AFP
34 testicular germ cell cancer 9.9 KIT AFP
35 choriocarcinoma of the testis 9.9 SALL4 AFP
36 spindle cell sarcoma 9.9 NUTM1 KIT
37 ovarian primitive germ cell tumor 9.9 SALL4 AFP
38 ovarian endodermal sinus tumor 9.9 SALL4 AFP
39 endodermal sinus tumor 9.9 SALL4 AFP
40 testicular disease 9.9 KIT AFP
41 testicular malignant germ cell cancer 9.9 SALL4 AFP
42 brain germinoma 9.8 TFAP2C KIT AFP
43 testicular germ cell tumor 9.8 KIT AFP
44 central nervous system germ cell tumor 9.8 SALL4 AFP
45 hepatoid adenocarcinoma 9.8 SALL4 AFP
46 mediastinal cancer 9.8 NUTM1 KIT AFP
47 blood coagulation disease 9.8 KIT AFP
48 benign teratoma 9.8 SALL4 AFP
49 bilirubin metabolic disorder 9.7 KIT AFP
50 mixed germ cell cancer 9.6 SALL4 KIT AFP

Graphical network of the top 20 diseases related to Extragonadal Seminoma:



Diseases related to Extragonadal Seminoma

Symptoms & Phenotypes for Extragonadal Seminoma

Drugs & Therapeutics for Extragonadal Seminoma

Drugs for Extragonadal Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
2
Fluorouracil Approved Phase 2 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
4
leucovorin Approved Phase 2 58-05-9 6006
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
6
Alvocidib Experimental, Investigational Phase 2 146426-40-6, 131740-09-5 5287969
7 Micronutrients Phase 2
8 Antidotes Phase 2
9 Trace Elements Phase 2
10 Nutrients Phase 2
11 Vitamin B Complex Phase 2
12 Folate Phase 2
13 Hormones Phase 2
14 Immunosuppressive Agents Phase 2
15 Protective Agents Phase 2
16 Hematinics Phase 2
17 Vitamin B9 Phase 2
18 Protein Kinase Inhibitors Phase 2
19 Vitamins Phase 2
20 Calcium, Dietary Phase 2
21 Immunologic Factors Phase 2
22 Antimetabolites Phase 2
23
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin

Search NIH Clinical Center for Extragonadal Seminoma

Genetic Tests for Extragonadal Seminoma

Anatomical Context for Extragonadal Seminoma

MalaCards organs/tissues related to Extragonadal Seminoma:

40
Liver, Testis, Lymph Node, Pancreas, Thyroid, Thymus, Brain

Publications for Extragonadal Seminoma

Articles related to Extragonadal Seminoma:

(show all 48)
# Title Authors PMID Year
1
Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report. 61
30069432 2018
2
Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma. 61
30263965 2018
3
Mediastinal seminoma presenting with superior vena cava syndrome. 61
28596199 2017
4
Primary rectal seminoma with the presence of disorder of sex development characteristics: a case report. 61
31966877 2017
5
Rapidly Progressive Systemic Sclerosis in a Patient With Suspected Extragonadal Seminoma. 61
26398473 2015
6
Primary extragonadal germ cell tumor: A case report on prostate seminoma. 61
26622843 2015
7
A rare association of extragonadal seminoma with synchronous papillary carcinoma of the thyroid. 61
24626380 2014
8
Endoscopic ultrasound and fine needle aspiration for the diagnosis of extragonadal seminoma metastatic to the pancreas. 61
25409049 2014
9
Seminoma presenting as a polypoid bladder mass: a case report. 61
24272936 2014
10
Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. 61
23374840 2013
11
Extragonadal seminoma presenting as a large mass in the pelvic cavity without c-kit-activating mutations. 61
22581924 2012
12
Mediastinal extragonadal seminoma presenting as severe back pain in a young male. 61
22073516 2011
13
FDG PET imaging in a patient with primary seminoma of the prostate. 61
21637070 2011
14
Serotonin used as prognostic marker of urological tumors. 61
18581119 2008
15
Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. 61
18045648 2008
16
Upper gastrointestinal hemorrhage as a rare extragonadal presentation of seminoma of testis. 61
17430271 2007
17
A case of primary extragonadal seminoma arising in the perineum. 61
16679842 2006
18
Testicular seminoma metastasizing to the parotid gland: report of a case. 61
15920749 2005
19
Prognostic variables for response and outcome in patients with extragonadal germ-cell tumors. 61
12176779 2002
20
High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer. 61
12010324 2002
21
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. 61
11283942 2001
22
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. 61
11917946 2001
23
Metastatic extragonadal seminoma associated with cardiac transplantation. 61
10942066 2000
24
[Extragonadal seminoma with testicular microlithiasis: a case report]. 61
10586369 1999
25
[Occult extragonadal seminoma in a thymic cyst]. 61
8963061 1996
26
Leydig cell hyperplasia mimicking testicular neoplasm. 61
8886077 1996
27
Chemotherapy in advanced seminoma and the role of postcytostatic retroperitoneal lymph node dissection. 61
8840489 1996
28
Gallium-67-citrate imaging in extragonadal and gonadal seminomas: relationship to radiologic findings. 61
7931660 1994
29
[Multifocal germ cell tumors]. 61
7811113 1994
30
Extragonadal seminoma involving urinary bladder and arising in the prostate. 61
8508362 1993
31
[Seminoma in extragonadal locations]. 61
8249401 1993
32
The role of radiotherapy in patients with advanced seminomatous germ cell tumors. Controversies in management. Part 2. 61
1323989 1992
33
Successful use of cisplatin to treat metastatic seminoma during cisplatin-induced acute renal failure. 61
1913514 1991
34
Sonographic diagnosis of testicular seminoma occurring 8 years after initial extragonadal seminoma. 61
1942238 1991
35
Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. 61
1847433 1991
36
Extragonadal sacrococcygeal seminoma--a case report. 61
2342241 1990
37
[The extragonadal seminoma: a differential diagnosis for mediastinal growth]. 61
2587926 1989
38
[Metastatic penile tumor of extragonadal seminoma: a case report]. 61
3066213 1988
39
Chylous ascites following retroperitoneal lymph node dissection successfully treated with peritoneovenous shunt. 61
3682840 1987
40
Vinblastine-ifosfamide-cisplatin treatment of bulky seminoma. 61
3756768 1986
41
Cis-platinum therapy in a patient with extragonadal seminoma and hydronephrosis of the only functioning kidney. A case report. 61
2424104 1986
42
The results of chemotherapy for extragonadal germ-cell tumors in the cisplatin era: the Memorial Sloan-Kettering Cancer Center experience (1975 to 1982). 61
2410574 1985
43
VAB-6 as initial treatment of patients with advanced seminoma. 61
2579214 1985
44
The treatment of extragonadal seminoma. 61
6204019 1984
45
Complete remission in extragonadal seminoma primarily treated with chemotherapy and restaged by retroperitoneal nodal dissection. 61
6192802 1983
46
Elevated serum calcitonin associated with an extragonadal seminoma. 61
7109118 1982
47
Simultaneous (non-epidermoid) neoplasms involving the head and neck. 61
7464404 1981
48
[Extragonadal seminoma in the mediastinum]. 61
5368148 1969

Variations for Extragonadal Seminoma

Expression for Extragonadal Seminoma

Search GEO for disease gene expression data for Extragonadal Seminoma.

Pathways for Extragonadal Seminoma

GO Terms for Extragonadal Seminoma

Biological processes related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.16 TFAP2C KIT
2 somatic stem cell population maintenance GO:0035019 8.96 SALL4 KIT
3 stem cell population maintenance GO:0019827 8.62 SALL4 KIT

Sources for Extragonadal Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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