MCID: EXT001
MIFTS: 36

Extragonadal Seminoma

Categories: Cancer diseases

Aliases & Classifications for Extragonadal Seminoma

MalaCards integrated aliases for Extragonadal Seminoma:

Name: Extragonadal Seminoma 12 15 73
Primary Extragonadal Seminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5838
NCIt 50 C7327
UMLS 73 C1333502

Summaries for Extragonadal Seminoma

MalaCards based summary : Extragonadal Seminoma, also known as primary extragonadal seminoma, is related to seminoma and mixed germ cell tumor. An important gene associated with Extragonadal Seminoma is LRRC4C (Leucine Rich Repeat Containing 4C), and among its related pathways/superpathways are Wnt Signaling Pathway and Pluripotency and Mesodermal Commitment Pathway. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and kidney, and related phenotype is embryo.

Related Diseases for Extragonadal Seminoma

Diseases related to Extragonadal Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 seminoma 29.9 AFP KIT POU5F1 TNFRSF8
2 mixed germ cell tumor 10.8 AFP KIT
3 hepatic angiomyolipoma 10.7 AFP KIT
4 ovarian germ cell cancer 10.7 AFP SALL4
5 spermatocytoma 10.7 KIT SALL4
6 brain germinoma 10.6 AFP POU5F1
7 embryonal testis carcinoma 10.6 AFP POU5F1
8 endometrial small cell carcinoma 10.6 AFP KIT
9 mediastinal cancer 10.5 AFP KIT
10 liver leiomyoma 10.5 CEACAM5 KIT
11 fox-fordyce disease 10.5 CEACAM5 KIT
12 mucinous cystadenofibroma 10.5 AFP CEACAM5
13 urachal adenocarcinoma 10.5 AFP CEACAM5
14 mucinous adenofibroma 10.5 CEACAM5 SEM1
15 liver lymphoma 10.5 AFP CEACAM5
16 extragonadal nonseminomatous germ cell tumor 10.5 AFP NUTM1
17 adenoid basal cell carcinoma 10.4 CEACAM5 KIT
18 melanotic medulloblastoma 10.4 AFP CEACAM5
19 mature teratoma 10.4 AFP POU5F1
20 aggressive digital papillary adenocarcinoma 10.4 CEACAM5 KIT
21 testicular leukemia 10.4 POU5F1 TFAP2C
22 hematocele of tunica vaginalis testis 10.4 AFP CEACAM5
23 malignant teratoma 10.4 AFP POU5F1 SALL4
24 bile duct cystadenocarcinoma 10.4 AFP CEACAM5
25 testicular granulosa cell tumor 10.3 AFP CEACAM5
26 non-functioning pancreatic endocrine tumor 10.3 POU5F1 SOX17 SOX2
27 juvenile type testicular granulosa cell tumor 10.3 AFP CEACAM5
28 urticaria pigmentosa 10.3 CALCA KIT
29 liver sarcoma 10.3 AFP CEACAM5
30 central nervous system germ cell tumor 10.3 AFP POU5F1 SOX2
31 atypical follicular adenoma 10.3 CALCA CEACAM5
32 ovarian endodermal sinus tumor 10.2 AFP SALL4
33 warthin tumor 10.2 CEACAM5 KIT
34 orbital cyst 10.2 CEACAM5 SOX2
35 rete testis adenocarcinoma 10.2 AFP CEACAM5 KIT
36 rete testis neoplasm 10.2 AFP CEACAM5 KIT
37 acute thyroiditis 10.2 CALCA CEACAM5
38 gastrointestinal system cancer 10.1 AFP CEACAM5 KIT
39 ovarian solid teratoma 10.1 AFP TNFRSF8
40 extragonadal germ cell cancer 10.1 AFP NUTM1 POU5F1
41 sternum cancer 10.1 AFP TNFRSF8
42 pineoblastoma 10.1 AFP POU5F1
43 malignant biphasic mesothelioma 10.0 AFP CEACAM5
44 nut midline carcinoma 10.0 BRD4 NUTM1 SOX2
45 pancreatic cystadenocarcinoma 10.0 AFP CALCA CEACAM5
46 teratoma 10.0 AFP KIT POU5F1 SOX2
47 conventional fibrosarcoma 10.0 KIT TNFRSF8
48 scleroderma, familial progressive 9.9
49 hydronephrosis 9.9
50 prostatitis 9.9

Graphical network of the top 20 diseases related to Extragonadal Seminoma:



Diseases related to Extragonadal Seminoma

Symptoms & Phenotypes for Extragonadal Seminoma

MGI Mouse Phenotypes related to Extragonadal Seminoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.17 KIT NANOG POU5F1 SALL4 SOX17 SOX2

Drugs & Therapeutics for Extragonadal Seminoma

Drugs for Extragonadal Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
2
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 84093 441203 2767
4
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
5
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
6
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
7
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
9
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
10
Bleomycin Approved, Investigational Phase 2, Phase 3 11056-06-7 5360373
11
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13
Vinblastine Approved Phase 3 865-21-4 13342 241903
14 Dexamethasone acetate Phase 3,Phase 2,Phase 1 1177-87-3
15
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
16 Alkylating Agents Phase 3,Phase 2,Phase 1
17 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
18 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
19 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
20 Anti-Bacterial Agents Phase 2, Phase 3
21 Antibiotics, Antitubercular Phase 2, Phase 3
22 Etoposide phosphate Phase 2, Phase 3,Phase 3
23 BB 1101 Phase 3,Phase 2,Phase 1
24 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
26 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
27 Histamine H2 Antagonists Phase 3
28
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
29
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
30
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
31
Ranitidine Approved Phase 1, Phase 2 66357-59-3, 66357-35-5 3001055
32
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
33
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
34
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
35
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
36
Fluorouracil Approved Phase 2 51-21-8 3385
37
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
38
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
39
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
41
Alvocidib Experimental, Investigational Phase 2 146426-40-6, 131740-09-5 5287969
42 Ranitidine bismuth citrate Phase 1, Phase 2
43
Chlorpheniramine Phase 1, Phase 2 113-92-8, 132-22-9 2725
44 glucocorticoids Phase 2
45 Gastrointestinal Agents Phase 2
46 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
47 Hormone Antagonists Phase 2
48 Hormones Phase 2
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
50 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
3 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
4 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
5 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
6 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
7 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
8 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
9 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
10 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
11 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
12 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
13 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
14 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
15 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
16 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel

Search NIH Clinical Center for Extragonadal Seminoma

Genetic Tests for Extragonadal Seminoma

Anatomical Context for Extragonadal Seminoma

MalaCards organs/tissues related to Extragonadal Seminoma:

41
Bone, Prostate, Kidney, Pancreas

Publications for Extragonadal Seminoma

Articles related to Extragonadal Seminoma:

(show all 15)
# Title Authors Year
1
Rapidly Progressive Systemic Sclerosis in a Patient With Suspected Extragonadal Seminoma. ( 26398473 )
2015
2
Endoscopic ultrasound and fine needle aspiration for the diagnosis of extragonadal seminoma metastatic to the pancreas. ( 25409049 )
2014
3
Extragonadal seminoma presenting as a large mass in the pelvic cavity without c-kit-activating mutations. ( 22581924 )
2012
4
Mediastinal extragonadal seminoma presenting as severe back pain in a young male. ( 22073516 )
2011
5
A case of primary extragonadal seminoma arising in the perineum. ( 16679842 )
2006
6
Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas. ( 16918976 )
2006
7
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. ( 11917946 )
2001
8
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. ( 11283942 )
2001
9
Metastatic extragonadal seminoma associated with cardiac transplantation. ( 10942066 )
2000
10
Extragonadal seminoma involving urinary bladder and arising in the prostate. ( 8508362 )
1993
11
Sonographic diagnosis of testicular seminoma occurring 8 years after initial extragonadal seminoma. ( 1942238 )
1991
12
Cis-platinum therapy in a patient with extragonadal seminoma and hydronephrosis of the only functioning kidney. A case report. ( 2424104 )
1986
13
The treatment of extragonadal seminoma. ( 6204019 )
1984
14
Complete remission in extragonadal seminoma primarily treated with chemotherapy and restaged by retroperitoneal nodal dissection. ( 6192802 )
1983
15
Elevated serum calcitonin associated with an extragonadal seminoma. ( 7109118 )
1982

Variations for Extragonadal Seminoma

Expression for Extragonadal Seminoma

Search GEO for disease gene expression data for Extragonadal Seminoma.

Pathways for Extragonadal Seminoma

GO Terms for Extragonadal Seminoma

Biological processes related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.91 KIT NANOG POU5F1 SALL4 SOX2 TNFRSF8
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.85 POU5F1 SALL4 SOX17 SOX2 TFAP2C
3 transcription by RNA polymerase II GO:0006366 9.72 NANOG POU5F1 SALL4 SOX2 TFAP2C
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.7 BRD4 NANOG POU5F1 SALL4 SOX17 SOX2
5 cytokine-mediated signaling pathway GO:0019221 9.67 KIT LRRC4C NANOG SOX2
6 stem cell population maintenance GO:0019827 9.43 KIT NANOG SALL4
7 mRNA transcription by RNA polymerase II GO:0042789 9.4 POU5F1 SOX17
8 endodermal cell fate specification GO:0001714 9.13 NANOG POU5F1 SOX2
9 somatic stem cell population maintenance GO:0035019 9.02 KIT NANOG POU5F1 SALL4 SOX2

Molecular functions related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.73 NANOG POU5F1 SALL4 SOX17 SOX2 TFAP2C
2 sequence-specific DNA binding GO:0043565 9.55 NANOG POU5F1 SALL4 SOX17 SOX2
3 protein binding GO:0005515 9.53 ADGRV1 AFP BRD4 CALCA KIT LRRC4C
4 miRNA binding GO:0035198 9.37 POU5F1 SOX2
5 cytokine binding GO:0019955 9.32 KIT POU5F1
6 transcription regulatory region DNA binding GO:0044212 9.26 NANOG SALL4 SOX17 SOX2

Sources for Extragonadal Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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