MCID: EXT001
MIFTS: 36

Extragonadal Seminoma

Categories: Cancer diseases

Aliases & Classifications for Extragonadal Seminoma

MalaCards integrated aliases for Extragonadal Seminoma:

Name: Extragonadal Seminoma 12 15 73
Primary Extragonadal Seminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5838
NCIt 50 C7327
UMLS 73 C1333502

Summaries for Extragonadal Seminoma

MalaCards based summary : Extragonadal Seminoma, also known as primary extragonadal seminoma, is related to seminoma and mixed germ cell tumor. An important gene associated with Extragonadal Seminoma is LRRC4C (Leucine Rich Repeat Containing 4C), and among its related pathways/superpathways are Wnt Signaling Pathway and Pluripotency and Mesodermal Commitment Pathway. The drugs Paclitaxel and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and brain, and related phenotype is embryo.

Related Diseases for Extragonadal Seminoma

Diseases related to Extragonadal Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 seminoma 30.7 AFP KIT POU5F1 TNFRSF8
2 mixed germ cell tumor 10.2 AFP KIT
3 hepatic angiomyolipoma 10.2 AFP KIT
4 ovarian germ cell cancer 10.2 AFP SALL4
5 brain germinoma 10.2 AFP POU5F1
6 endometrial small cell carcinoma 10.2 AFP KIT
7 spermatocytoma 10.2 KIT SALL4
8 embryonal testis carcinoma 10.2 AFP POU5F1
9 mediastinal cancer 10.2 AFP KIT
10 helsmoortel-van der aa syndrome 10.2 KIT SALL4
11 liver leiomyoma 10.2 CEACAM5 KIT
12 fox-fordyce disease 10.2 CEACAM5 KIT
13 mucinous adenofibroma 10.1 CEACAM5 SEM1
14 mucinous cystadenofibroma 10.1 AFP CEACAM5
15 mature teratoma 10.1 AFP POU5F1
16 liver lymphoma 10.1 AFP CEACAM5
17 extragonadal nonseminomatous germ cell tumor 10.1 AFP NUTM1
18 ovarian endodermal sinus tumor 10.1 AFP SALL4
19 melanotic medulloblastoma 10.1 AFP CEACAM5
20 urachal adenocarcinoma 10.1 AFP CEACAM5
21 mixed germ cell-sex cord neoplasm 10.1 KIT POU5F1 SALL4
22 endodermal sinus tumor 10.1 AFP SALL4
23 adenoid basal cell carcinoma 10.1 CEACAM5 KIT
24 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 KIT
25 hematocele of tunica vaginalis testis 10.1 AFP CEACAM5
26 malignant teratoma 10.1 AFP POU5F1 SALL4
27 bile duct cystadenocarcinoma 10.1 AFP CEACAM5
28 functional colonic disease 10.1 BRD4 KIT
29 non-functioning pancreatic endocrine tumor 10.1 POU5F1 SOX17 SOX2
30 liver sarcoma 10.1 AFP CEACAM5
31 testicular leukemia 10.1 POU5F1 TFAP2C
32 pineoblastoma 10.1 AFP POU5F1
33 orbital cyst 10.1 CEACAM5 SOX2
34 central nervous system germ cell tumor 10.1 AFP POU5F1 SOX2
35 warthin tumor 10.1 CEACAM5 KIT
36 atypical follicular adenoma 10.1 CALCA CEACAM5
37 rete testis adenocarcinoma 10.1 AFP CEACAM5 KIT
38 rete testis neoplasm 10.1 AFP CEACAM5 KIT
39 mixed germ cell cancer 10.1 AFP POU5F1
40 scleroderma, familial progressive 10.0
41 hydronephrosis 10.0
42 papillary carcinoma 10.0
43 testicular seminoma 10.0
44 gastrointestinal system cancer 10.0 AFP CEACAM5 KIT
45 ovarian solid teratoma 10.0 AFP TNFRSF8
46 fetal adenoma 10.0 CALCA CEACAM5
47 extragonadal germ cell cancer 10.0 AFP NUTM1 POU5F1
48 sternum cancer 10.0 AFP TNFRSF8
49 gastrointestinal system disease 10.0 AFP CEACAM5 KIT
50 conventional fibrosarcoma 10.0 KIT TNFRSF8

Graphical network of the top 20 diseases related to Extragonadal Seminoma:



Diseases related to Extragonadal Seminoma

Symptoms & Phenotypes for Extragonadal Seminoma

MGI Mouse Phenotypes related to Extragonadal Seminoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.17 KIT NANOG POU5F1 SALL4 SOX17 SOX2

Drugs & Therapeutics for Extragonadal Seminoma

Drugs for Extragonadal Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
3
Bleomycin Approved, Investigational Phase 2, Phase 3 11056-06-7 5360373
4
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
6
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
9
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
10
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
11
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
14
Vinblastine Approved Phase 3 865-21-4 241903 13342
15 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
16 Etoposide phosphate Phase 2, Phase 3,Phase 3
17 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
18 Antibiotics, Antitubercular Phase 2, Phase 3
19 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
20 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
21 Anti-Bacterial Agents Phase 2, Phase 3
22 Immunologic Factors Phase 3,Phase 1,Phase 2
23 BB 1101 Phase 3,Phase 2,Phase 1
24
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
26 Alkylating Agents Phase 3,Phase 2,Phase 1
27 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
28 Histamine H2 Antagonists Phase 3
29
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
30
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
31
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
32
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
33
Ranitidine Approved Phase 1, Phase 2 66357-35-5, 66357-59-3 3001055
34
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
35
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
36
leucovorin Approved Phase 2 58-05-9 6006 143
37
Fluorouracil Approved Phase 2 51-21-8 3385
38
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
39
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5330286 5005498
40
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
42
Alvocidib Experimental, Investigational Phase 2 131740-09-5, 146426-40-6 5287969
43 Antineoplastic Agents, Hormonal Phase 2
44 Anti-Inflammatory Agents Phase 2
45 Antiemetics Phase 2
46 glucocorticoids Phase 2
47 Gastrointestinal Agents Phase 2
48 Hormone Antagonists Phase 2
49 Peripheral Nervous System Agents Phase 2
50 Autonomic Agents Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
3 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
4 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
5 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
6 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
7 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
10 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
11 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
12 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
13 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
14 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
15 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
16 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel

Search NIH Clinical Center for Extragonadal Seminoma

Genetic Tests for Extragonadal Seminoma

Anatomical Context for Extragonadal Seminoma

MalaCards organs/tissues related to Extragonadal Seminoma:

41
Bone, Lung, Brain, Liver, Colon, Ovary, Testis

Publications for Extragonadal Seminoma

Articles related to Extragonadal Seminoma:

(show all 17)
# Title Authors Year
1
Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report. ( 30069432 )
2018
2
Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma. ( 30263965 )
2018
3
Rapidly Progressive Systemic Sclerosis in a Patient With Suspected Extragonadal Seminoma. ( 26398473 )
2015
4
Endoscopic ultrasound and fine needle aspiration for the diagnosis of extragonadal seminoma metastatic to the pancreas. ( 25409049 )
2014
5
A rare association of extragonadal seminoma with synchronous papillary carcinoma of the thyroid. ( 24626380 )
2014
6
Extragonadal seminoma presenting as a large mass in the pelvic cavity without c-kit-activating mutations. ( 22581924 )
2012
7
Mediastinal extragonadal seminoma presenting as severe back pain in a young male. ( 22073516 )
2011
8
A case of primary extragonadal seminoma arising in the perineum. ( 16679842 )
2006
9
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. ( 11917946 )
2001
10
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. ( 11283942 )
2001
11
Metastatic extragonadal seminoma associated with cardiac transplantation. ( 10942066 )
2000
12
Extragonadal seminoma involving urinary bladder and arising in the prostate. ( 8508362 )
1993
13
Sonographic diagnosis of testicular seminoma occurring 8 years after initial extragonadal seminoma. ( 1942238 )
1991
14
Cis-platinum therapy in a patient with extragonadal seminoma and hydronephrosis of the only functioning kidney. A case report. ( 2424104 )
1986
15
The treatment of extragonadal seminoma. ( 6204019 )
1984
16
Complete remission in extragonadal seminoma primarily treated with chemotherapy and restaged by retroperitoneal nodal dissection. ( 6192802 )
1983
17
Elevated serum calcitonin associated with an extragonadal seminoma. ( 7109118 )
1982

Variations for Extragonadal Seminoma

Expression for Extragonadal Seminoma

Search GEO for disease gene expression data for Extragonadal Seminoma.

Pathways for Extragonadal Seminoma

GO Terms for Extragonadal Seminoma

Cellular components related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear transcription factor complex GO:0044798 8.62 SOX17 SOX2

Biological processes related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.77 POU5F1 SALL4 SOX17 SOX2 TFAP2C
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.7 BRD4 NANOG POU5F1 SALL4 SOX17 SOX2
3 stem cell population maintenance GO:0019827 9.43 KIT NANOG SALL4
4 mRNA transcription by RNA polymerase II GO:0042789 9.32 POU5F1 SOX17
5 endodermal cell fate specification GO:0001714 9.13 NANOG POU5F1 SOX2
6 somatic stem cell population maintenance GO:0035019 9.02 KIT NANOG POU5F1 SALL4 SOX2

Molecular functions related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 ADGRV1 AFP BRD4 CALCA KIT LRRC4C

Sources for Extragonadal Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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