MCID: EXT001
MIFTS: 27

Extragonadal Seminoma

Categories: Cancer diseases

Aliases & Classifications for Extragonadal Seminoma

MalaCards integrated aliases for Extragonadal Seminoma:

Name: Extragonadal Seminoma 12 15 71
Primary Extragonadal Seminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5838
NCIt 49 C7327
UMLS 71 C1333502

Summaries for Extragonadal Seminoma

MalaCards based summary : Extragonadal Seminoma, also known as primary extragonadal seminoma, is related to seminoma and germinoma. An important gene associated with Extragonadal Seminoma is TFAP2C (Transcription Factor AP-2 Gamma), and among its related pathways/superpathways is Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and kidney.

Related Diseases for Extragonadal Seminoma

Diseases related to Extragonadal Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 seminoma 31.1 KIT AFP
2 germinoma 30.1 KIT AFP
3 testicular seminoma 10.2
4 scleroderma, familial progressive 10.1
5 testicular microlithiasis 10.1
6 hydronephrosis 10.1
7 penile benign neoplasm 10.1
8 dilated cardiomyopathy 10.1
9 benign mesothelioma 10.1
10 papillary carcinoma 10.1
11 liver cirrhosis 10.1
12 end stage renal disease 10.1
13 germ cells tumors 10.1
14 back pain 10.1
15 rare tumor 10.1
16 thyroid carcinoma 10.1
17 pediatric germ cell cancer 10.0 TFAP2C AFP
18 teratoma 10.0 KIT AFP
19 mixed germ cell tumor 10.0 KIT AFP
20 mediastinum seminoma 10.0 KIT AFP
21 pineal region teratoma 10.0 KIT AFP
22 gallbladder leiomyosarcoma 10.0 KIT AFP
23 liver leiomyoma 9.9 KIT AFP
24 intratubular embryonal carcinoma 9.9 KIT AFP
25 ovarian mixed germ cell neoplasm 9.9 KIT AFP
26 hepatic angiomyolipoma 9.9 KIT AFP
27 angiomyolipoma 9.9 KIT AFP
28 dysgerminoma of ovary 9.9 KIT AFP
29 liver leiomyosarcoma 9.9 KIT AFP
30 ovarian gonadoblastoma 9.9 KIT AFP
31 sarcomatous intrahepatic cholangiocarcinoma 9.9 KIT AFP
32 endometrial small cell carcinoma 9.8 KIT AFP
33 mediastinal cancer 9.8 KIT AFP
34 choriocarcinoma of the testis 9.8 SALL4 AFP
35 ovarian endodermal sinus tumor 9.8 SALL4 AFP
36 ovarian primitive germ cell tumor 9.8 SALL4 AFP
37 childhood endodermal sinus tumor 9.8 SALL4 AFP
38 mixed cell type cancer 9.8 KIT AFP
39 testicular malignant germ cell cancer 9.8 SALL4 AFP
40 cystic teratoma 9.7 KIT AFP
41 central nervous system germ cell tumor 9.7 SALL4 AFP
42 cavernous hemangioma 9.7 KIT AFP
43 brain germinoma 9.7 TFAP2C KIT AFP
44 mixed germ cell-sex cord neoplasm 9.7 SALL4 KIT
45 cystadenoma 9.7 KIT AFP
46 hepatoid adenocarcinoma 9.6 SALL4 AFP
47 testicular germ cell tumor 9.6 KIT AFP
48 testicular disease 9.4 KIT AFP
49 mixed germ cell cancer 9.4 SALL4 KIT AFP
50 germ cell cancer 9.4 SALL4 KIT AFP

Graphical network of the top 20 diseases related to Extragonadal Seminoma:



Diseases related to Extragonadal Seminoma

Symptoms & Phenotypes for Extragonadal Seminoma

Drugs & Therapeutics for Extragonadal Seminoma

Drugs for Extragonadal Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
2
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
3
Bleomycin Approved, Investigational Phase 2, Phase 3 11056-06-7 5360373
4
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
5
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
6
Ifosfamide Approved Phase 3 3778-73-2 3690
7
Vinblastine Approved Phase 3 865-21-4 241903 13342
8 Etoposide phosphate Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3
11 Albumin-Bound Paclitaxel Phase 3
12
Isophosphamide mustard Phase 3 0
13 Tubulin Modulators Phase 3
14 Alkylating Agents Phase 3
15 Antimitotic Agents Phase 3
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
17
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
18
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
19
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
20
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 6251 453
21
Chlorpheniramine Approved Phase 1, Phase 2 132-22-9, 113-92-8 2725
22
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
23
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
24
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
25
leucovorin Approved Phase 2 58-05-9 6006 143
26
Fluorouracil Approved Phase 2 51-21-8 3385
27
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
28
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
29
Mesna Approved, Investigational Phase 2 3375-50-6 598
30
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
31
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
32
Alvocidib Experimental, Investigational Phase 2 131740-09-5, 146426-40-6 5287969
33 Gastrointestinal Agents Phase 2
34 Antineoplastic Agents, Hormonal Phase 2
35 Antiemetics Phase 2
36 Hormone Antagonists Phase 2
37 glucocorticoids Phase 2
38 Anti-Inflammatory Agents Phase 2
39 Adjuvants, Immunologic Phase 1, Phase 2
40 Ranitidine bismuth citrate Phase 1, Phase 2
41 Anti-Infective Agents Phase 1, Phase 2
42 Antiviral Agents Phase 1, Phase 2
43 BB 1101 Phase 1, Phase 2
44 Hormones Phase 2
45 Protein Kinase Inhibitors Phase 2
46 Angiogenesis Inhibitors Phase 2
47 Antimetabolites Phase 2
48 Micronutrients Phase 2
49 Trace Elements Phase 2
50 Vitamins Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
3 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
4 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
5 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
6 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
7 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
8 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
9 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
10 A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
11 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
12 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
13 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel

Search NIH Clinical Center for Extragonadal Seminoma

Genetic Tests for Extragonadal Seminoma

Anatomical Context for Extragonadal Seminoma

MalaCards organs/tissues related to Extragonadal Seminoma:

40
Lymph Node, Prostate, Kidney, Pancreas, Thyroid, Testis

Publications for Extragonadal Seminoma

Articles related to Extragonadal Seminoma:

(show all 48)
# Title Authors PMID Year
1
Retroperitoneal extragonadal seminoma developed with acute lower inferior vena cava syndrome: A case report. 61
30069432 2018
2
Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma. 61
30263965 2018
3
Mediastinal seminoma presenting with superior vena cava syndrome. 61
28596199 2017
4
Primary rectal seminoma with the presence of disorder of sex development characteristics: a case report. 61
31966877 2017
5
Rapidly Progressive Systemic Sclerosis in a Patient With Suspected Extragonadal Seminoma. 61
26398473 2015
6
Primary extragonadal germ cell tumor: A case report on prostate seminoma. 61
26622843 2015
7
A rare association of extragonadal seminoma with synchronous papillary carcinoma of the thyroid. 61
24626380 2014
8
Seminoma presenting as a polypoid bladder mass: a case report. 61
24272936 2014
9
Endoscopic ultrasound and fine needle aspiration for the diagnosis of extragonadal seminoma metastatic to the pancreas. 61
25409049 2014
10
Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. 61
23374840 2013
11
Extragonadal seminoma presenting as a large mass in the pelvic cavity without c-kit-activating mutations. 61
22581924 2012
12
Mediastinal extragonadal seminoma presenting as severe back pain in a young male. 61
22073516 2011
13
FDG PET imaging in a patient with primary seminoma of the prostate. 61
21637070 2011
14
Serotonin used as prognostic marker of urological tumors. 61
18581119 2008
15
Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. 61
18045648 2008
16
Upper gastrointestinal hemorrhage as a rare extragonadal presentation of seminoma of testis. 61
17430271 2007
17
A case of primary extragonadal seminoma arising in the perineum. 61
16679842 2006
18
Testicular seminoma metastasizing to the parotid gland: report of a case. 61
15920749 2005
19
Prognostic variables for response and outcome in patients with extragonadal germ-cell tumors. 61
12176779 2002
20
High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer. 61
12010324 2002
21
Extragonadal seminoma: an international multicenter analysis of prognostic factors and long term treatment outcome. 61
11283942 2001
22
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. 61
11917946 2001
23
Metastatic extragonadal seminoma associated with cardiac transplantation. 61
10942066 2000
24
[Extragonadal seminoma with testicular microlithiasis: a case report]. 61
10586369 1999
25
[Occult extragonadal seminoma in a thymic cyst]. 61
8963061 1996
26
Leydig cell hyperplasia mimicking testicular neoplasm. 61
8886077 1996
27
Chemotherapy in advanced seminoma and the role of postcytostatic retroperitoneal lymph node dissection. 61
8840489 1996
28
Gallium-67-citrate imaging in extragonadal and gonadal seminomas: relationship to radiologic findings. 61
7931660 1994
29
[Multifocal germ cell tumors]. 61
7811113 1994
30
Extragonadal seminoma involving urinary bladder and arising in the prostate. 61
8508362 1993
31
[Seminoma in extragonadal locations]. 61
8249401 1993
32
The role of radiotherapy in patients with advanced seminomatous germ cell tumors. Controversies in management. Part 2. 61
1323989 1992
33
Successful use of cisplatin to treat metastatic seminoma during cisplatin-induced acute renal failure. 61
1913514 1991
34
Sonographic diagnosis of testicular seminoma occurring 8 years after initial extragonadal seminoma. 61
1942238 1991
35
Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. 61
1847433 1991
36
Extragonadal sacrococcygeal seminoma--a case report. 61
2342241 1990
37
[The extragonadal seminoma: a differential diagnosis for mediastinal growth]. 61
2587926 1989
38
[Metastatic penile tumor of extragonadal seminoma: a case report]. 61
3066213 1988
39
Chylous ascites following retroperitoneal lymph node dissection successfully treated with peritoneovenous shunt. 61
3682840 1987
40
Vinblastine-ifosfamide-cisplatin treatment of bulky seminoma. 61
3756768 1986
41
Cis-platinum therapy in a patient with extragonadal seminoma and hydronephrosis of the only functioning kidney. A case report. 61
2424104 1986
42
The results of chemotherapy for extragonadal germ-cell tumors in the cisplatin era: the Memorial Sloan-Kettering Cancer Center experience (1975 to 1982). 61
2410574 1985
43
VAB-6 as initial treatment of patients with advanced seminoma. 61
2579214 1985
44
The treatment of extragonadal seminoma. 61
6204019 1984
45
Complete remission in extragonadal seminoma primarily treated with chemotherapy and restaged by retroperitoneal nodal dissection. 61
6192802 1983
46
Elevated serum calcitonin associated with an extragonadal seminoma. 61
7109118 1982
47
Simultaneous (non-epidermoid) neoplasms involving the head and neck. 61
7464404 1981
48
[Extragonadal seminoma in the mediastinum]. 61
5368148 1969

Variations for Extragonadal Seminoma

Expression for Extragonadal Seminoma

Search GEO for disease gene expression data for Extragonadal Seminoma.

Pathways for Extragonadal Seminoma

GO Terms for Extragonadal Seminoma

Biological processes related to Extragonadal Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.16 TFAP2C KIT
2 somatic stem cell population maintenance GO:0035019 8.96 SALL4 KIT
3 stem cell population maintenance GO:0019827 8.62 SALL4 KIT

Sources for Extragonadal Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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