MCID: EXT006
MIFTS: 40

Extrahepatic Cholestasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Extrahepatic Cholestasis

MalaCards integrated aliases for Extrahepatic Cholestasis:

Name: Extrahepatic Cholestasis 12 15
Cholestasis, Extrahepatic 44 73
Extrahepatic Obstructive Biliary Disease 12
Extrahepatic Biliary Stasis 12
Cholestasis Extrahepatic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:13619
MeSH 44 D001651
NCIt 50 C34420
SNOMED-CT 68 20719006 8262006
UMLS 73 C0005398

Summaries for Extrahepatic Cholestasis

MalaCards based summary : Extrahepatic Cholestasis, also known as cholestasis, extrahepatic, is related to choledocholithiasis and cholestasis, and has symptoms including icterus An important gene associated with Extrahepatic Cholestasis is ABCC3 (ATP Binding Cassette Subfamily C Member 3), and among its related pathways/superpathways are Glucose / Energy Metabolism and NRF2 pathway. The drugs DEFB1 protein, human and Menthol have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related phenotype is homeostasis/metabolism.

Related Diseases for Extrahepatic Cholestasis

Graphical network of the top 20 diseases related to Extrahepatic Cholestasis:



Diseases related to Extrahepatic Cholestasis

Symptoms & Phenotypes for Extrahepatic Cholestasis

UMLS symptoms related to Extrahepatic Cholestasis:


icterus

MGI Mouse Phenotypes related to Extrahepatic Cholestasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 ABCB4 ABCC1 ABCC2 ABCC3 CYP7A1 FGF19

Drugs & Therapeutics for Extrahepatic Cholestasis

Drugs for Extrahepatic Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 DEFB1 protein, human Phase 3
2
Menthol Approved Not Applicable 2216-51-5 16666
3
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
4 Antibodies
5 Immunoglobulins
6 Antibodies, Antineutrophil Cytoplasmic
7 Analgesics Not Applicable
8 Fibrinolytic Agents Not Applicable
9 Cyclooxygenase Inhibitors Not Applicable
10 Analgesics, Non-Narcotic Not Applicable
11 Peripheral Nervous System Agents Not Applicable
12 Platelet Aggregation Inhibitors Not Applicable
13 Anti-Inflammatory Agents Not Applicable
14 Antipyretics Not Applicable
15 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
16 Antirheumatic Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
2 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
3 Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis Completed NCT03237247
4 Ultrasound-guided Percutaneous Biliary Drainage With Primary Metal Implantation by Endoscopic Luminal Guidance Completed NCT03541590
5 Endoscopic Ultrasound as an Early Diagnostic Tool for Primary Sclerosing Cholangitis Completed NCT01556412
6 Randomized Trial of Wire and Sphincterotome Systems for Biliary Cannulation Completed NCT02197338 Not Applicable
7 EUS-guided Biliary Drainage Versus Percutanenous Transhepatic Biliary Darinage for Malignant Biliary Obstruction After Failed ERCP Completed NCT02103413 Not Applicable
8 Comparison Between Novel Flower-type Covered Stent and Conventional Covered Stent Recruiting NCT03215108 Not Applicable
9 The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction Recruiting NCT03279809 Not Applicable Aspirin;Placebo
10 Reconstruction of the Bile Duct With the Round Ligament Recruiting NCT03030573 Not Applicable
11 Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage Not yet recruiting NCT03546049 Not Applicable

Search NIH Clinical Center for Extrahepatic Cholestasis

Cochrane evidence based reviews: cholestasis, extrahepatic

Genetic Tests for Extrahepatic Cholestasis

Anatomical Context for Extrahepatic Cholestasis

MalaCards organs/tissues related to Extrahepatic Cholestasis:

41
Liver, Testes, Kidney, Brain

Publications for Extrahepatic Cholestasis

Articles related to Extrahepatic Cholestasis:

(show top 50) (show all 137)
# Title Authors Year
1
Prostaglandin E1 Preconditioning Attenuates Liver Ischemia Reperfusion Injury in a Rat Model of Extrahepatic Cholestasis. ( 29511679 )
2018
2
Hepatoprotective activities of rosmarinic acid against extrahepatic cholestasis in rats. ( 28789951 )
2017
3
Qualification for endoscopic retrograde cholangiopancreatography in the diagnosis and treatment of extrahepatic cholestasis caused by choledocholithiasis. ( 26788082 )
2015
4
Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats. ( 26383596 )
2015
5
Efficacy of diffusion-weighted magnetic resonance imaging in the evaluation of extrahepatic cholestasis-related hepatic fibrosis. ( 26281340 )
2015
6
Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation. ( 25126202 )
2014
7
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. ( 23978715 )
2014
8
Influence of distal ileum exclusion on hepatic and renal functions in presence of extrahepatic cholestasis. ( 24918724 )
2014
9
Increase of glycosaminoglycans and metalloproteinases 2 and 9 in liver extracellular matrix on early stages of extrahepatic cholestasis. ( 25591159 )
2014
10
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis. ( 23197884 )
2012
11
The effects of chitosan and low dose dexamethasone on extrahepatic cholestasis after bile duct ligation in Wistar rats. ( 22425809 )
2012
12
Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A. ( 22306509 )
2012
13
Acoustic radiation force impulse elastography: a better option for patients with extrahepatic cholestasis. ( 22081004 )
2012
14
Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis. ( 22087164 )
2011
15
Liver stiffness in extrahepatic cholestasis correlates positively with bilirubin and negatively with alanine aminotransferase. ( 21435129 )
2011
16
Gastrointestinal stromal tumor in a patient with undiagnosed neurofibromatosis type I: an uncommon cause of extrahepatic cholestasis. ( 20352594 )
2010
17
Effect of L-arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. ( 19283445 )
2010
18
Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis. ( 19628226 )
2010
19
Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis. ( 20153989 )
2010
20
Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. ( 20578263 )
2010
21
Extrahepatic cholestasis and liver stiffness by transient elastography. ( 19241481 )
2009
22
The diameter of common bile duct does not predict the cause of extrahepatic cholestasis. ( 19238062 )
2009
23
High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. ( 19185005 )
2009
24
An unusual cause of extrahepatic cholestasis. ( 18187368 )
2008
25
Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis. ( 18836992 )
2008
26
Biliary fibrosis in microsurgical extrahepatic cholestasis in the rat. ( 18561272 )
2008
27
Altered expression and distribution of aquaporin-9 in the liver of rat with obstructive extrahepatic cholestasis. ( 18669624 )
2008
28
Effect of ATRA on contents of liver retinoids, oxidative stress and hepatic injury in rat model of extrahepatic cholestasis. ( 18060617 )
2007
29
Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. ( 17845533 )
2007
30
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. ( 17141734 )
2007
31
Fluvastatin reduced liver injury in rat model of extrahepatic cholestasis. ( 17086424 )
2007
32
Stone or stricture as a cause of extrahepatic cholestasis--do liver function tests predict the diagnosis? ( 17163822 )
2006
33
The role of imaging methods in identifying the causes of extrahepatic cholestasis. ( 17013452 )
2006
34
Pyloric obstruction, duodenal dilatation, and extrahepatic cholestasis: a neonatal triad suggesting multiple intestinal atresias. ( 17011287 )
2006
35
Usual and unusual causes of extrahepatic cholestasis: assessment with magnetic resonance cholangiography and fast MRI. ( 15160760 )
2004
36
Microsurgical extrahepatic cholestasis in the rat: a long-term study. ( 15204716 )
2004
37
Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis. ( 15378799 )
2004
38
Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis. ( 15377894 )
2004
39
Comparative study of macro- and microsurgical extrahepatic cholestasis in the rat. ( 15389969 )
2004
40
Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis. ( 14670824 )
2004
41
Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. ( 12940443 )
2003
42
Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis. ( 12717383 )
2003
43
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. ( 14623915 )
2003
44
Extrahepatic cholestasis: are there any "leftovers" for surgeons? ( 11202286 )
2000
45
Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis. ( 9862868 )
1999
46
Intercellular adhesion molecule-1 (ICAM-1) expression in the liver of patients with extrahepatic cholestasis. ( 9542581 )
1998
47
Benzoic acid metabolism reflects hepatic mitochondrial function in rats with long-term extrahepatic cholestasis. ( 9021934 )
1997
48
A molecular basis for jaundice in intrahepatic and extrahepatic cholestasis. ( 9398017 )
1997
49
Extrahepatic cholestasis attributable to tuberculous adenitis. ( 9149224 )
1997
50
Alterations of hepatocellular intermediate filaments during extrahepatic cholestasis in rat liver. ( 9099984 )
1997

Variations for Extrahepatic Cholestasis

Expression for Extrahepatic Cholestasis

Search GEO for disease gene expression data for Extrahepatic Cholestasis.

Pathways for Extrahepatic Cholestasis

Pathways related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.25 ABCC1 ABCC2 ABCC3
2 11.85 ABCC2 ABCC3 GGT1
3
Show member pathways
11.82 ABCC1 ABCC2 ABCC3
4
Show member pathways
11.35 ABCC2 MPO
5
Show member pathways
11.33 ABCC1 ABCC2
6 11.31 ABCB4 ABCC2 ABCC3 CYP7A1
7
Show member pathways
11.18 ABCC1 ABCC2
8
Show member pathways
11.15 ABCC2 ABCC3
9 11.12 ABCC1 ABCC2 ABCC3
10 11.06 ABCC2 ABCC3
11 11.01 ABCC2 MPO
12 10.92 ABCC2 ABCC3
13
Show member pathways
10.91 ABCC1 ABCC2 ABCC3
14 10.89 ABCC1 ABCC2
15 10.86 ABCB4 CYP7A1 FGF19
16 10.8 ABCC1 ABCC2 ABCC3
17 10.73 ABCC2 ABCC3 CYP7A1
18 10.61 ABCC1 ABCC3 MPO
19 10.59 ABCC1 ABCC2
20 10.47 ABCB4 ABCC2 ABCC3 CYP7A1
21 10.13 ABCC1 ABCC2 ABCC3

GO Terms for Extrahepatic Cholestasis

Cellular components related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border membrane GO:0031526 8.96 ABCB4 ABCC2
2 intercellular canaliculus GO:0046581 8.62 ABCB4 ABCC2

Biological processes related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.8 ABCB4 ABCC1 ABCC2 ABCC3
2 response to drug GO:0042493 9.69 ABCB4 ABCC1 ABCC2
3 response to lipopolysaccharide GO:0032496 9.63 ABCB4 ABCC2 MPO
4 cellular response to dexamethasone stimulus GO:0071549 9.48 ABCB4 ABCC2
5 phospholipid translocation GO:0045332 9.43 ABCB4 ABCC1
6 leukotriene metabolic process GO:0006691 9.4 ABCC1 GGT1
7 response to glucagon GO:0033762 9.37 ABCB4 ABCC2
8 ATP hydrolysis coupled anion transmembrane transport GO:0099133 9.33 ABCC1 ABCC2 ABCC3
9 response to antineoplastic agent GO:0097327 9.32 ABCB4 ABCC2
10 canalicular bile acid transport GO:0015722 9.26 ABCC2 ABCC3
11 xenobiotic transport GO:0042908 9.13 ABCB4 ABCC1 ABCC3
12 drug transmembrane transport GO:0006855 8.92 ABCB4 ABCC1 ABCC2 ABCC3

Molecular functions related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.62 ABCB4 ABCC1 ABCC2 ABCC3
2 transmembrane transporter activity GO:0022857 9.54 ABCC1 ABCC2 ABCC3
3 organic anion transmembrane transporter activity GO:0008514 9.43 ABCC1 ABCC2 ABCC3
4 ATPase-coupled anion transmembrane transporter activity GO:0043225 9.33 ABCC1 ABCC2 ABCC3
5 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.26 ABCB4 ABCC1 ABCC2 ABCC3
6 xenobiotic transmembrane transporting ATPase activity GO:0008559 8.8 ABCB4 ABCC1 ABCC3

Sources for Extrahepatic Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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