MCID: EXT006
MIFTS: 41

Extrahepatic Cholestasis

Categories: Gastrointestinal diseases

Aliases & Classifications for Extrahepatic Cholestasis

MalaCards integrated aliases for Extrahepatic Cholestasis:

Name: Extrahepatic Cholestasis 12 15 17
Cholestasis, Extrahepatic 45 74
Extrahepatic Obstructive Biliary Disease 12
Extrahepatic Biliary Stasis 12
Cholestasis Extrahepatic 56

Classifications:



External Ids:

Disease Ontology 12 DOID:13619
MeSH 45 D001651
NCIt 51 C34420
SNOMED-CT 69 20719006 8262006
UMLS 74 C0005398

Summaries for Extrahepatic Cholestasis

MalaCards based summary : Extrahepatic Cholestasis, also known as cholestasis, extrahepatic, is related to choledocholithiasis and cholestasis, and has symptoms including icterus An important gene associated with Extrahepatic Cholestasis is ABCC3 (ATP Binding Cassette Subfamily C Member 3), and among its related pathways/superpathways are Glucose / Energy Metabolism and NRF2 pathway. The drugs DEFB1 protein, human and Phenobarbital have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and kidney, and related phenotypes are homeostasis/metabolism and integument

Related Diseases for Extrahepatic Cholestasis

Graphical network of the top 20 diseases related to Extrahepatic Cholestasis:



Diseases related to Extrahepatic Cholestasis

Symptoms & Phenotypes for Extrahepatic Cholestasis

UMLS symptoms related to Extrahepatic Cholestasis:


icterus

MGI Mouse Phenotypes related to Extrahepatic Cholestasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 ABCC1 ABCC2 ABCC3 CYP7A1 FGF19 GGT1
2 integument MP:0010771 8.92 ABCC3 CYP7A1 GGT1 TFAM

Drugs & Therapeutics for Extrahepatic Cholestasis

Drugs for Extrahepatic Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 DEFB1 protein, human Phase 3
2
Phenobarbital Approved, Investigational 50-06-6 4763
3
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
4 Neurotransmitter Agents
5 Central Nervous System Depressants
6 Excitatory Amino Acid Antagonists
7 Cytochrome P-450 CYP3A Inducers
8 GABA Modulators
9 Anticonvulsants
10 GABA Agents
11 Excitatory Amino Acids
12 Hypnotics and Sedatives
13 Antibodies ,Not Applicable
14 Antibodies, Antineutrophil Cytoplasmic
15 Immunoglobulins ,Not Applicable
16 Peripheral Nervous System Agents Not Applicable
17 Fibrinolytic Agents Not Applicable
18 Anti-Inflammatory Agents Not Applicable
19 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
20 Antipyretics Not Applicable
21 Cyclooxygenase Inhibitors Not Applicable
22 Analgesics Not Applicable
23 Analgesics, Non-Narcotic Not Applicable
24 Antirheumatic Agents Not Applicable
25 Platelet Aggregation Inhibitors Not Applicable
26 Immunologic Factors Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction Completed NCT00433771 Phase 3
2 Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents Completed NCT02114320 Phase 3
3 Reconstruction of the Bile Duct With the Round Ligament Unknown status NCT03030573 Not Applicable
4 Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis Completed NCT03237247
5 Ultrasound-guided Percutaneous Biliary Drainage With Primary Metal Implantation by Endoscopic Luminal Guidance Completed NCT03541590
6 Endoscopic Ultrasound as an Early Diagnostic Tool for Primary Sclerosing Cholangitis Completed NCT01556412
7 Randomized Trial of Wire and Sphincterotome Systems for Biliary Cannulation Completed NCT02197338 Not Applicable
8 EUS-guided Biliary Drainage Versus Percutanenous Transhepatic Biliary Darinage for Malignant Biliary Obstruction After Failed ERCP Completed NCT02103413 Not Applicable
9 Comparison Between Novel Flower-type Covered Stent and Conventional Covered Stent Recruiting NCT03215108 Not Applicable
10 Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage Recruiting NCT03546049 Not Applicable
11 The Effect of Aspirin on Patency of Metal Stent in Malignant Distal Bile Duct Obstruction Recruiting NCT03279809 Not Applicable Aspirin;Placebo
12 Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction Recruiting NCT03821025 Not Applicable
13 Development of a New Immunochemistry Method Using Antibodies of Proteins Related Bile Duct Cancer Recruiting NCT03708445 Not Applicable

Search NIH Clinical Center for Extrahepatic Cholestasis

Cochrane evidence based reviews: cholestasis, extrahepatic

Genetic Tests for Extrahepatic Cholestasis

Anatomical Context for Extrahepatic Cholestasis

MalaCards organs/tissues related to Extrahepatic Cholestasis:

42
Liver, Brain, Kidney, Testes

Publications for Extrahepatic Cholestasis

Articles related to Extrahepatic Cholestasis:

(show top 50) (show all 139)
# Title Authors Year
1
Bile modulates secretion of incretins and insulin: a study on human extrahepatic cholestasis. ( 30874733 )
2019
2
Prostaglandin E1 Preconditioning Attenuates Liver Ischemia Reperfusion Injury in a Rat Model of Extrahepatic Cholestasis. ( 29511679 )
2018
3
Hepatoprotective activities of rosmarinic acid against extrahepatic cholestasis in rats. ( 28789951 )
2017
4
Qualification for endoscopic retrograde cholangiopancreatography in the diagnosis and treatment of extrahepatic cholestasis caused by choledocholithiasis. ( 26788082 )
2015
5
Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats. ( 26383596 )
2015
6
Efficacy of diffusion-weighted magnetic resonance imaging in the evaluation of extrahepatic cholestasis-related hepatic fibrosis. ( 26281340 )
2015
7
Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation. ( 25126202 )
2014
8
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. ( 23978715 )
2014
9
Influence of distal ileum exclusion on hepatic and renal functions in presence of extrahepatic cholestasis. ( 24918724 )
2014
10
Increase of glycosaminoglycans and metalloproteinases 2 and 9 in liver extracellular matrix on early stages of extrahepatic cholestasis. ( 25591159 )
2014
11
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis. ( 23197884 )
2012
12
The effects of chitosan and low dose dexamethasone on extrahepatic cholestasis after bile duct ligation in Wistar rats. ( 22425809 )
2012
13
Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A. ( 22306509 )
2012
14
Acoustic radiation force impulse elastography: a better option for patients with extrahepatic cholestasis. ( 22081004 )
2012
15
Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis. ( 22087164 )
2011
16
Liver stiffness in extrahepatic cholestasis correlates positively with bilirubin and negatively with alanine aminotransferase. ( 21435129 )
2011
17
Gastrointestinal stromal tumor in a patient with undiagnosed neurofibromatosis type I: an uncommon cause of extrahepatic cholestasis. ( 20352594 )
2010
18
Effect of L-arginine on metabolism of polyamines in rat's brain with extrahepatic cholestasis. ( 19283445 )
2010
19
Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis. ( 19628226 )
2010
20
Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis. ( 20153989 )
2010
21
Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. ( 20578263 )
2010
22
Extrahepatic cholestasis and liver stiffness by transient elastography. ( 19241481 )
2009
23
The diameter of common bile duct does not predict the cause of extrahepatic cholestasis. ( 19238062 )
2009
24
High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. ( 19185005 )
2009
25
An unusual cause of extrahepatic cholestasis. ( 18187368 )
2008
26
Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis. ( 18836992 )
2008
27
Biliary fibrosis in microsurgical extrahepatic cholestasis in the rat. ( 18561272 )
2008
28
Altered expression and distribution of aquaporin-9 in the liver of rat with obstructive extrahepatic cholestasis. ( 18669624 )
2008
29
Effect of ATRA on contents of liver retinoids, oxidative stress and hepatic injury in rat model of extrahepatic cholestasis. ( 18060617 )
2007
30
Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. ( 17845533 )
2007
31
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. ( 17141734 )
2007
32
Fluvastatin reduced liver injury in rat model of extrahepatic cholestasis. ( 17086424 )
2007
33
Stone or stricture as a cause of extrahepatic cholestasis--do liver function tests predict the diagnosis? ( 17163822 )
2006
34
The role of imaging methods in identifying the causes of extrahepatic cholestasis. ( 17013452 )
2006
35
Pyloric obstruction, duodenal dilatation, and extrahepatic cholestasis: a neonatal triad suggesting multiple intestinal atresias. ( 17011287 )
2006
36
Usual and unusual causes of extrahepatic cholestasis: assessment with magnetic resonance cholangiography and fast MRI. ( 15160760 )
2004
37
Microsurgical extrahepatic cholestasis in the rat: a long-term study. ( 15204716 )
2004
38
Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis. ( 15378799 )
2004
39
Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis. ( 15377894 )
2004
40
Comparative study of macro- and microsurgical extrahepatic cholestasis in the rat. ( 15389969 )
2004
41
Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis. ( 14670824 )
2004
42
Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. ( 12940443 )
2003
43
Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis. ( 12717383 )
2003
44
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. ( 14623915 )
2003
45
Extrahepatic cholestasis: are there any "leftovers" for surgeons? ( 11202286 )
2000
46
Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis. ( 9862868 )
1999
47
Intercellular adhesion molecule-1 (ICAM-1) expression in the liver of patients with extrahepatic cholestasis. ( 9542581 )
1998
48
Benzoic acid metabolism reflects hepatic mitochondrial function in rats with long-term extrahepatic cholestasis. ( 9021934 )
1997
49
A molecular basis for jaundice in intrahepatic and extrahepatic cholestasis. ( 9398017 )
1997
50
Extrahepatic cholestasis attributable to tuberculous adenitis. ( 9149224 )
1997

Variations for Extrahepatic Cholestasis

Expression for Extrahepatic Cholestasis

Search GEO for disease gene expression data for Extrahepatic Cholestasis.

Pathways for Extrahepatic Cholestasis

Pathways related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.24 ABCC1 ABCC2 ABCC3
2 11.83 ABCC2 ABCC3 GGT1
3
Show member pathways
11.81 ABCC1 ABCC2 ABCC3
4 11.47 ABCC2 ABCC3 CYP7A1
5
Show member pathways
11.4 ABCC2 MPO
6
Show member pathways
11.33 ABCC1 ABCC2
7
Show member pathways
11.17 ABCC1 ABCC2
8 11.12 ABCC2 ABCC3 CYP7A1
9 11.06 ABCC2 ABCC3
10 11.04 ABCC1 ABCC2 ABCC3
11 11.01 ABCC2 MPO
12 10.92 ABCC2 ABCC3
13 10.89 ABCC1 ABCC2
14
Show member pathways
10.8 ABCC1 ABCC2 ABCC3
15 10.79 CYP7A1 FGF19
16 10.69 ABCC1 ABCC2 ABCC3
17 10.57 ABCC1 ABCC2
18 10.56 ABCC2 ABCC3 CYP7A1
19 10.31 ABCC1 ABCC3 MPO
20 9.8 ABCC1 ABCC2 ABCC3

GO Terms for Extrahepatic Cholestasis

Cellular components related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vacuolar membrane GO:0005774 8.62 ABCC1 ABCC3

Biological processes related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.43 ABCC2 GGT1 MPO
2 drug transmembrane transport GO:0006855 9.32 ABCC1 ABCC2
3 leukotriene metabolic process GO:0006691 9.16 ABCC1 GGT1
4 canalicular bile acid transport GO:0015722 8.96 ABCC2 ABCC3
5 ATP hydrolysis coupled anion transmembrane transport GO:0099133 8.8 ABCC1 ABCC2 ABCC3

Molecular functions related to Extrahepatic Cholestasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.5 ABCC1 ABCC2 ABCC3
2 transmembrane transporter activity GO:0022857 9.43 ABCC1 ABCC2 ABCC3
3 organic anion transmembrane transporter activity GO:0008514 9.16 ABCC2 ABCC3
4 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.13 ABCC1 ABCC2 ABCC3
5 ATPase-coupled anion transmembrane transporter activity GO:0043225 8.8 ABCC1 ABCC2 ABCC3

Sources for Extrahepatic Cholestasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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