MCID: EXT029
MIFTS: 24

Extraocular Retinoblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Extraocular Retinoblastoma

MalaCards integrated aliases for Extraocular Retinoblastoma:

Name: Extraocular Retinoblastoma 12 15 71
Pediatric Extraocular Retinoblastoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4656
NCIt 49 C7848
UMLS 71 C0278719 C1321870

Summaries for Extraocular Retinoblastoma

Disease Ontology : 12 A retinoblastoma that has spread from the soft tissues surrounding the eye or to the optic nerve beyond the margin of resection to other parts of the body.

MalaCards based summary : Extraocular Retinoblastoma, also known as pediatric extraocular retinoblastoma, is related to retinoblastoma and pediatric extraocular retinoblastoma. An important gene associated with Extraocular Retinoblastoma is MDM4 (MDM4 Regulator Of P53). The drugs Adjuvants, Immunologic and Podophyllotoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and liver, and related phenotype is pigmentation.

Related Diseases for Extraocular Retinoblastoma

Diseases related to Extraocular Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 retinoblastoma 29.0 RBL2 MDM4 KIF14 DEK CRX
2 pediatric extraocular retinoblastoma 12.8
3 familial retinoblastoma 10.6
4 neutropenia 10.0
5 retinal cancer 9.8 RBL2 MDM4
6 intraocular retinoblastoma 9.8 MDM4 CRX
7 bilateral retinoblastoma 9.6 VSX2 RBL2 MDM4
8 eye degenerative disease 9.5 VSX2 CRX
9 unilateral retinoblastoma 9.4 VSX2 RBL2 MDM4 KIF14

Graphical network of the top 20 diseases related to Extraocular Retinoblastoma:



Diseases related to Extraocular Retinoblastoma

Symptoms & Phenotypes for Extraocular Retinoblastoma

MGI Mouse Phenotypes related to Extraocular Retinoblastoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 CRX MDM4 VSX2

Drugs & Therapeutics for Extraocular Retinoblastoma

Drugs for Extraocular Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adjuvants, Immunologic Phase 3
2 Podophyllotoxin Phase 3 518-28-5
3 Keratolytic Agents Phase 3
4
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
5
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
6
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
7
Iodine Approved, Investigational Phase 2 7553-56-2 807
8
Promethazine Approved, Investigational Phase 2 60-87-7 4927
9
Acetaminophen Approved Phase 2 103-90-2 1983
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
11
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
12
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
13 Antibiotics, Antitubercular Phase 2
14
Liposomal doxorubicin Phase 2 31703
15 topoisomerase I inhibitors Phase 2
16 Anti-Bacterial Agents Phase 2
17 Antibodies Phase 2
18 Antibodies, Monoclonal Phase 2
19 Immunoglobulins Phase 2
20 cadexomer iodine Phase 2
21
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
22
Mesna Approved, Investigational Phase 1 3375-50-6 598
23
Ifosfamide Approved Phase 1 3778-73-2 3690
24
Busulfan Approved, Investigational Phase 1 55-98-1 2478
25
Melphalan Approved Phase 1 148-82-3 460612 4053
26 Molgramostim Investigational Phase 1 99283-10-0
27 Liver Extracts Phase 1
28
Isophosphamide mustard Phase 1 0
29
Cytarabine Approved, Experimental, Investigational 147-94-4, 65-46-3 6253
30
Ethanol Approved 64-17-5 702
31 Anti-Infective Agents
32 Antiviral Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 CEV With/Without Periocular Carboplatin Chemotherapy for Nonmetastatic Extraocular Retinoblastoma Carboplatin--A Single Center, Retrospective Study to Evaluate the Efficacy of Carboplatin in Subjects With Retinoblastoma Completed NCT02319486 Phase 4 carboplatin periocular injection;CEV chemotherapy
2 A Trial of Intensive Multi-Modality Therapy for Extra-Ocular Retinoblastoma Active, not recruiting NCT00554788 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Thiotepa;Vincristine Sulfate
3 A Single Arm Trial of Systemic And Subtenon Chemotherapy For Groups C And D Intraocular Retinoblastoma Terminated NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
4 Treatment for Extrachoroidal or Metastatic Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
5 Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
6 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
7 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
8 Dose Intensive Chemotherapy for Children Less Than Ten Years of Age Newly-Diagnosed With Malignant Brain Tumors: A Pilot Study of Two Alternative Intensive Induction Chemotherapy Regimens, Followed by Consolidation With Myeloablative Chemotherapy (Thiotepa, Etoposide and Carboplatin) and Autologous Stem Cell Rescue Withdrawn NCT00003273 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;leucovorin calcium;methotrexate;temozolomide;thiotepa;vincristine sulfate
9 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
10 Dose Escalation of Total Marrow Irradiation Added to an Alkylator-Intense Conditioning Regimen for Patients With High Risk or Relapsed Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
11 A Data Collection Study to Compare the Outcome for Children With Advanced Unilateral Retinoblastoma Treated With or Without Post-Enucleation Chemotherapy ± Radiotherapy on RB 2005 11 With Historical Controls Receiving no Additional Therapy Unknown status NCT00360750 carboplatin;cytarabine;etoposide;vincristine sulfate
12 Carcinogen Metabolism, DNA Repair, Parental Exposures and Retinoblastoma Completed NCT00690469

Search NIH Clinical Center for Extraocular Retinoblastoma

Genetic Tests for Extraocular Retinoblastoma

Anatomical Context for Extraocular Retinoblastoma

MalaCards organs/tissues related to Extraocular Retinoblastoma:

40
Eye, Brain, Liver, Spinal Cord

Publications for Extraocular Retinoblastoma

Articles related to Extraocular Retinoblastoma:

(show all 31)
# Title Authors PMID Year
1
Global Retinoblastoma Presentation and Analysis by National Income Level. 61
32105305 2020
2
Successful Treatment of Relapsed Isolated Extraocular Retinoblastoma in the Right Fibula With High-dose Chemotherapy and Autologous Stem Cell Transplantation. 61
30933027 2019
3
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. 61
28984344 2019
4
Combined high-dose intra-arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma. 61
30105793 2018
5
Magnetic resonance imaging for tumor restaging after chemotherapy in retinoblastoma with optic nerve invasion. 61
30089224 2018
6
Retinoblastoma in Sub-Saharan Africa: Case Studies of the Republic of Côte d'Ivoire and the Democratic Republic of the Congo. 61
30241234 2018
7
Outcome of extraocular retinoblastoma in a resource limited center from low middle income country. 61
29337595 2017
8
Extraocular retinoblastoma: a neglected case. 61
28546235 2017
9
Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. 61
26959658 2016
10
[Clinical features of retinoblastoma in Tunisia]. 61
24792399 2014
11
Retinoblastoma in Turkey: results from a tertiary care center in Ankara. 61
23937863 2013
12
Comparison of staging systems for extraocular retinoblastoma: analysis of 533 patients. 61
23787805 2013
13
Extraocular retinoblastoma in Indian children: clinical, imaging and histopathological features. 61
23991383 2013
14
Current therapy and recent advances in the management of retinoblastoma. 61
22988349 2012
15
Treatment and outcome of nonmetastatic extraocular retinoblastoma with a uniform chemotherapy protocol. 61
20168241 2010
16
Familial retinoblastoma in developing countries. 61
19434730 2009
17
Systemic metastasis following hyphema drainage in an unsuspected retinoblastoma. 61
17410964 2007
18
Retinoblastoma with spinal recurrence presenting as spinal cord compression. 61
16801038 2006
19
Results of treatment of retinoblastoma that has infiltrated the optic nerve, is recurrent, or has metastasized outside the eyeball. 61
15162820 2004
20
Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience. 61
14707710 2004
21
Encouraging result of tamoxifen in a retinoblastoma patient with central nervous system metastasis. 61
14631622 2003
22
Extraocular retinoblastoma: a 13-year experience. 61
12973854 2003
23
Treatment of overt extraocular retinoblastoma. 61
12518344 2003
24
Extraocular retinoblastoma. 61
10881012 2000
25
Phase II window of idarubicin in children with extraocular retinoblastoma. 61
10561224 1999
26
Role of chemotherapy alone or in combination with hyperthermia in the primary treatment of intraocular retinoblastoma: preliminary results. 61
9924303 1998
27
Proposal for a New Staging Scheme for Intraocular and Extraocular Retinoblastoma Based on an Analysis of 103 Globes. 61
10388023 1997
28
Etoposide and carboplatin in extraocular retinoblastoma: a study by the Société Française d'Oncologie Pédiatrique. 61
7707117 1995
29
Chemotherapy for extraocular retinoblastoma. 61
8060814 1994
30
Intraocular and extraocular retinoblastoma. 61
3323180 1987
31
The use of chemotherapy for extraocular retinoblastoma. 61
4046972 1985

Variations for Extraocular Retinoblastoma

Expression for Extraocular Retinoblastoma

Search GEO for disease gene expression data for Extraocular Retinoblastoma.

Pathways for Extraocular Retinoblastoma

GO Terms for Extraocular Retinoblastoma

Cellular components related to Extraocular Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 VSX2 TUT1 RBL2 NSL1 MDM4 KIF14

Biological processes related to Extraocular Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.62 RBL2 MDM4

Sources for Extraocular Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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