MCID: EXT029
MIFTS: 20

Extraocular Retinoblastoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Extraocular Retinoblastoma

MalaCards integrated aliases for Extraocular Retinoblastoma:

Name: Extraocular Retinoblastoma 12 72
Pediatric Extraocular Retinoblastoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:4656
NCIt 50 C7848
UMLS 72 C0278719 C1321870

Summaries for Extraocular Retinoblastoma

Disease Ontology : 12 A retinoblastoma that has spread from the soft tissues surrounding the eye or to the optic nerve beyond the margin of resection to other parts of the body.

MalaCards based summary : Extraocular Retinoblastoma, also known as pediatric extraocular retinoblastoma, is related to pediatric extraocular retinoblastoma and retinoblastoma. The drugs Emodepside and Keratolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and liver.

Related Diseases for Extraocular Retinoblastoma

Diseases related to Extraocular Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pediatric extraocular retinoblastoma 12.8
2 retinoblastoma 10.6
3 familial retinoblastoma 10.6
4 neutropenia 10.0

Symptoms & Phenotypes for Extraocular Retinoblastoma

Drugs & Therapeutics for Extraocular Retinoblastoma

Drugs for Extraocular Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
2 Keratolytic Agents Phase 3
3 Podophyllotoxin Phase 3 518-28-5
4 Adjuvants, Immunologic Phase 3
5
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
6
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
7
Iodine Approved, Investigational Phase 2 7553-56-2 807
8
Acetaminophen Approved Phase 2 103-90-2 1983
9
Promethazine Approved, Investigational Phase 2 60-87-7 4927
10
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
12
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
13
Liposomal doxorubicin Phase 2 31703
14 Anti-Bacterial Agents Phase 2
15 Antibiotics, Antitubercular Phase 2
16 topoisomerase I inhibitors Phase 2
17 Anti-Infective Agents Phase 2
18 Antibodies Phase 2
19 Antineoplastic Agents, Immunological Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunoglobulins Phase 2
22 cadexomer iodine Phase 2
23 Micronutrients Phase 2
24 Anti-Infective Agents, Local Phase 2
25 Nutrients Phase 2
26 Trace Elements Phase 2
27 BB 1101 Phase 2
28
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
29
Ifosfamide Approved Phase 1 3778-73-2 3690
30
Mesna Approved, Investigational Phase 1 3375-50-6 598
31
Melphalan Approved Phase 1 148-82-3 460612 4053
32
Mechlorethamine Approved, Investigational Phase 1 51-75-2 4033
33
Busulfan Approved, Investigational Phase 1 55-98-1 2478
34 Liver Extracts Phase 1
35
Isophosphamide mustard Phase 1 0
36
Cytarabine Approved, Experimental, Investigational 147-94-4, 65-46-3 6253
37
Ethanol Approved 64-17-5 702
38 Antiviral Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 CEV With/Without Periocular Carboplatin Chemotherapy for Nonmetastatic Extraocular Retinoblastoma Carboplatin--A Single Center, Retrospective Study to Evaluate the Efficacy of Carboplatin in Subjects With Retinoblastoma Completed NCT02319486 Phase 4 carboplatin periocular injection;CEV chemotherapy
2 A Trial of Intensive Multi-Modality Therapy for Extra-Ocular Retinoblastoma Active, not recruiting NCT00554788 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Thiotepa;Vincristine Sulfate
3 A Single Arm Trial of Systemic And Subtenon Chemotherapy For Groups C And D Intraocular Retinoblastoma Terminated NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
4 Treatment for Extrachoroidal or Metastatic Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
5 A Phase II Trial of Rebeccamycin Analogue (NSC #655649) in Children With Solid Tumors Completed NCT00006102 Phase 2 becatecarin
6 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
7 Dose Intensive Chemotherapy for Children Less Than Ten Years of Age Newly-Diagnosed With Malignant Brain Tumors: A Pilot Study of Two Alternative Intensive Induction Chemotherapy Regimens, Followed by Consolidation With Myeloablative Chemotherapy (Thiotepa, Etoposide and Carboplatin) and Autologous Stem Cell Rescue Withdrawn NCT00003273 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;leucovorin calcium;methotrexate;temozolomide;thiotepa;vincristine sulfate
8 Phase I Study of Intrathecal 131-I-3F8 Monoclonal Antibody in Patients With GD2 Positive Leptomeningeal Neoplasms Completed NCT00003022 Phase 1
9 Dose Escalation of Total Marrow Irradiation Added to an Alkylator-Intense Conditioning Regimen for Patients With High Risk or Relapsed Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
10 A Data Collection Study to Compare the Outcome for Children With Advanced Unilateral Retinoblastoma Treated With or Without Post-Enucleation Chemotherapy ± Radiotherapy on RB 2005 11 With Historical Controls Receiving no Additional Therapy Unknown status NCT00360750 carboplatin;cytarabine;etoposide;vincristine sulfate
11 Carcinogen Metabolism, DNA Repair, Parental Exposures and Retinoblastoma Completed NCT00690469

Search NIH Clinical Center for Extraocular Retinoblastoma

Genetic Tests for Extraocular Retinoblastoma

Anatomical Context for Extraocular Retinoblastoma

MalaCards organs/tissues related to Extraocular Retinoblastoma:

41
Eye, Brain, Liver, Spinal Cord

Publications for Extraocular Retinoblastoma

Articles related to Extraocular Retinoblastoma:

(show all 30)
# Title Authors PMID Year
1
Successful Treatment of Relapsed Isolated Extraocular Retinoblastoma in the Right Fibula With High-dose Chemotherapy and Autologous Stem Cell Transplantation. 38
30933027 2019
2
Combined high-dose intra-arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma. 38
30105793 2018
3
Magnetic resonance imaging for tumor restaging after chemotherapy in retinoblastoma with optic nerve invasion. 38
30089224 2018
4
Retinoblastoma in Sub-Saharan Africa: Case Studies of the Republic of Côte d'Ivoire and the Democratic Republic of the Congo. 38
30241234 2018
5
Outcome of extraocular retinoblastoma in a resource limited center from low middle income country. 38
29337595 2017
6
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. 38
28984344 2017
7
Extraocular retinoblastoma: a neglected case. 38
28546235 2017
8
Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. 38
26959658 2016
9
[Clinical features of retinoblastoma in Tunisia]. 38
24792399 2014
10
Retinoblastoma in Turkey: results from a tertiary care center in Ankara. 38
23937863 2013
11
Comparison of staging systems for extraocular retinoblastoma: analysis of 533 patients. 38
23787805 2013
12
Extraocular retinoblastoma in Indian children: clinical, imaging and histopathological features. 38
23991383 2013
13
Current therapy and recent advances in the management of retinoblastoma. 38
22988349 2012
14
Treatment and outcome of nonmetastatic extraocular retinoblastoma with a uniform chemotherapy protocol. 38
20168241 2010
15
Familial retinoblastoma in developing countries. 38
19434730 2009
16
Systemic metastasis following hyphema drainage in an unsuspected retinoblastoma. 38
17410964 2007
17
Retinoblastoma with spinal recurrence presenting as spinal cord compression. 38
16801038 2006
18
Results of treatment of retinoblastoma that has infiltrated the optic nerve, is recurrent, or has metastasized outside the eyeball. 38
15162820 2004
19
Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience. 38
14707710 2004
20
Encouraging result of tamoxifen in a retinoblastoma patient with central nervous system metastasis. 38
14631622 2003
21
Extraocular retinoblastoma: a 13-year experience. 38
12973854 2003
22
Treatment of overt extraocular retinoblastoma. 38
12518344 2003
23
Extraocular retinoblastoma. 38
10881012 2000
24
Phase II window of idarubicin in children with extraocular retinoblastoma. 38
10561224 1999
25
Role of chemotherapy alone or in combination with hyperthermia in the primary treatment of intraocular retinoblastoma: preliminary results. 38
9924303 1998
26
Proposal for a New Staging Scheme for Intraocular and Extraocular Retinoblastoma Based on an Analysis of 103 Globes. 38
10388023 1997
27
Etoposide and carboplatin in extraocular retinoblastoma: a study by the Société Française d'Oncologie Pédiatrique. 38
7707117 1995
28
Chemotherapy for extraocular retinoblastoma. 38
8060814 1994
29
Intraocular and extraocular retinoblastoma. 38
3323180 1987
30
The use of chemotherapy for extraocular retinoblastoma. 38
4046972 1985

Variations for Extraocular Retinoblastoma

Expression for Extraocular Retinoblastoma

Search GEO for disease gene expression data for Extraocular Retinoblastoma.

Pathways for Extraocular Retinoblastoma

GO Terms for Extraocular Retinoblastoma

Sources for Extraocular Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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