MCID: EXT029
MIFTS: 21

Extraocular Retinoblastoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Extraocular Retinoblastoma

MalaCards integrated aliases for Extraocular Retinoblastoma:

Name: Extraocular Retinoblastoma 12 74
Pediatric Extraocular Retinoblastoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4656
NCIt 51 C7848

Summaries for Extraocular Retinoblastoma

Disease Ontology : 12 A retinoblastoma that has spread from the soft tissues surrounding the eye or to the optic nerve beyond the margin of resection to other parts of the body.

MalaCards based summary : Extraocular Retinoblastoma, also known as pediatric extraocular retinoblastoma, is related to pediatric extraocular retinoblastoma and retinoblastoma. The drugs Etoposide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and brain.

Related Diseases for Extraocular Retinoblastoma

Diseases related to Extraocular Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pediatric extraocular retinoblastoma 12.6
2 retinoblastoma 10.6

Symptoms & Phenotypes for Extraocular Retinoblastoma

Drugs & Therapeutics for Extraocular Retinoblastoma

Drugs for Extraocular Retinoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
2
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
3
Carboplatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 41575-94-4 10339178 38904 498142
4 Antimitotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
9
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
10
Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1 52-24-4 5453
11
Sargramostim Approved, Investigational Phase 3,Phase 1 123774-72-1, 83869-56-1
12
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
13
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
14 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
15 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
16 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
17 Alkylating Agents Phase 3,Phase 2,Phase 1
18 Antirheumatic Agents Phase 3,Phase 2
19 Podophyllotoxin Phase 3 518-28-5
20 Adjuvants, Immunologic Phase 3,Phase 1
21 Dermatologic Agents Phase 3,Phase 2
22 Keratolytic Agents Phase 3
23
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
24
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
25
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
26
Iodine Approved, Investigational Phase 2,Phase 1 7553-56-2 807
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
28
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
29
Promethazine Approved, Investigational Phase 2 60-87-7 4927
30
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
31
Acetaminophen Approved Phase 2 103-90-2 1983
32
Doxil Approved June 1999 Phase 2 31703
33 Anti-Infective Agents Phase 2,Not Applicable
34 Antimetabolites, Antineoplastic Phase 2,Not Applicable
35 Antimetabolites Phase 2,Not Applicable
36 topoisomerase I inhibitors Phase 2
37 Anti-Bacterial Agents Phase 2
38 Antibiotics, Antitubercular Phase 2
39 Liver Extracts Phase 2,Phase 1
40 Antibodies Phase 2,Phase 1
41 cadexomer iodine Phase 2,Phase 1
42 Antineoplastic Agents, Immunological Phase 2,Phase 1
43 Antibodies, Monoclonal Phase 2,Phase 1
44 Immunoglobulins Phase 2,Phase 1
45 BB 1101 Phase 2
46 Nutrients Phase 2
47 Anti-Infective Agents, Local Phase 2
48 Micronutrients Phase 2
49 Trace Elements Phase 2
50 Protective Agents Phase 2,Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma Completed NCT02319486 Phase 4 carboplatin periocular injection;CEV chemotherapy
2 Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma Active, not recruiting NCT00554788 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Thiotepa;Vincristine Sulfate
3 Systemic Chemotherapy and Subtenon Carboplatin, and Local Ophthalmic Therapy in Children With Intraocular Retinoblastoma Terminated NCT00072384 Phase 3 liposomal vincristine sulfate;carboplatin;etoposide
4 Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinoblastoma Completed NCT00004006 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;topotecan hydrochloride
5 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
6 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
7 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
8 Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor Withdrawn NCT00003273 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;leucovorin calcium;methotrexate;temozolomide;thiotepa;vincristine sulfate
9 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
10 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1 busulfan;etoposide;ifosfamide;melphalan;thiotepa;Mesna
11 Chemotherapy With or Without Radiation Therapy or Observation in Treating Young Patients With Advanced Retinoblastoma Who Have Undergone Surgery to Remove the Eye Unknown status NCT00360750 Not Applicable carboplatin;cytarabine;etoposide;vincristine sulfate
12 Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers Completed NCT00690469
13 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755

Search NIH Clinical Center for Extraocular Retinoblastoma

Genetic Tests for Extraocular Retinoblastoma

Anatomical Context for Extraocular Retinoblastoma

MalaCards organs/tissues related to Extraocular Retinoblastoma:

42
Eye, Bone, Brain, Liver, Bone Marrow

Publications for Extraocular Retinoblastoma

Articles related to Extraocular Retinoblastoma:

(show all 17)
# Title Authors Year
1
Successful Treatment of Relapsed Isolated Extraocular Retinoblastoma in the Right Fibula With High-dose Chemotherapy and Autologous Stem Cell Transplantation. ( 30933027 )
2019
2
Combined high-dose intra-arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma. ( 30105793 )
2018
3
Extraocular retinoblastoma: a neglected case. ( 28546235 )
2017
4
Outcome of extraocular retinoblastoma in a resource limited center from low middle income country. ( 29337595 )
2017
5
Comparison of staging systems for extraocular retinoblastoma: analysis of 533 patients. ( 23787805 )
2013
6
Extraocular retinoblastoma in Indian children: clinical, imaging and histopathological features. ( 23991383 )
2013
7
Treatment and outcome of nonmetastatic extraocular retinoblastoma with a uniform chemotherapy protocol. ( 20168241 )
2010
8
Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience. ( 14707710 )
2004
9
Treatment of overt extraocular retinoblastoma. ( 12518344 )
2003
10
Extraocular retinoblastoma: a 13-year experience. ( 12973854 )
2003
11
Extraocular retinoblastoma. ( 10881012 )
2000
12
Phase II window of idarubicin in children with extraocular retinoblastoma. ( 10561224 )
1999
13
Proposal for a New Staging Scheme for Intraocular and Extraocular Retinoblastoma Based on an Analysis of 103 Globes. ( 10388023 )
1997
14
Etoposide and carboplatin in extraocular retinoblastoma: a study by the Société Française d'Oncologie Pédiatrique. ( 7707117 )
1995
15
Chemotherapy for extraocular retinoblastoma. ( 8060814 )
1994
16
Intraocular and extraocular retinoblastoma. ( 3323180 )
1987
17
The use of chemotherapy for extraocular retinoblastoma. ( 4046972 )
1985

Variations for Extraocular Retinoblastoma

Expression for Extraocular Retinoblastoma

Search GEO for disease gene expression data for Extraocular Retinoblastoma.

Pathways for Extraocular Retinoblastoma

GO Terms for Extraocular Retinoblastoma

Sources for Extraocular Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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