MCID: EXT030
MIFTS: 27

Extraosseous Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Extraosseous Chondrosarcoma

MalaCards integrated aliases for Extraosseous Chondrosarcoma:

Name: Extraosseous Chondrosarcoma 12 15
Extraskeletal Myxoid Chondrosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4549

Summaries for Extraosseous Chondrosarcoma

Disease Ontology : 12 A chondrosarcoma that is located in exclusively soft tissue.

MalaCards based summary : Extraosseous Chondrosarcoma, also known as extraskeletal myxoid chondrosarcoma, is related to chondrosarcoma and chondrosarcoma, extraskeletal myxoid. An important gene associated with Extraosseous Chondrosarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include exclusively soft tissue and brain.

Related Diseases for Extraosseous Chondrosarcoma

Diseases in the Extraosseous Chondrosarcoma family:

Adult Extraosseous Chondrosarcoma

Diseases related to Extraosseous Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.0 ENO2 EWSR1 TAF15 TFG
2 chondrosarcoma, extraskeletal myxoid 27.2 ENO2 EWSR1 FUS SMARCB1 SNRPC SYP
3 adult extraosseous chondrosarcoma 12.1
4 extraskeletal mesenchymal chondrosarcoma 11.1
5 myxoid chondrosarcoma 10.7 EWSR1 TAF15
6 juxtacortical chondroma 10.6 EWSR1 FUS
7 small cell osteogenic sarcoma 10.6 ENO2 EWSR1
8 askin's tumor 10.6 ENO2 EWSR1
9 ideomotor apraxia 10.5 EWSR1 FUS
10 bone ewing's sarcoma 10.4 ENO2 EWSR1
11 extraosseous ewing's sarcoma 10.4 ENO2 EWSR1
12 chondroid lipoma 10.3 ENO2 FUS
13 muscle cancer 10.3 ENO2 EWSR1
14 skin sarcoma 10.3 EWSR1 SYP
15 fibrous histiocytoma 10.3 EWSR1 FUS
16 ureter small cell carcinoma 10.2 ENO2 SYP
17 malignant sertoli cell tumor 10.2 ENO2 SYP
18 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
19 auditory system cancer 10.2 ENO2 SYP
20 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
21 sensory organ benign neoplasm 10.2 ENO2 SYP
22 gallbladder small cell carcinoma 10.2 ENO2 SYP
23 pancreatic somatostatinoma 10.2 ENO2 SYP
24 cutaneous ganglioneuroma 10.2 ENO2 SYP
25 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
26 small cell carcinoma of the bladder 10.2 ENO2 SYP
27 papillary tumor of the pineal region 10.2 ENO2 SYP
28 middle ear adenoma 10.2 ENO2 SYP
29 ovarian carcinosarcoma 10.2 ENO2 SYP
30 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
31 myxoid liposarcoma 10.2 EWSR1 FUS
32 atypical follicular adenoma 10.2 ENO2 SYP
33 central nervous system primitive neuroectodermal neoplasm 10.2 ENO2 SYP
34 cerebellum cancer 10.2 ENO2 SYP
35 subependymal glioma 10.2 ENO2 SYP
36 vulvar sarcoma 10.2 EWSR1 SMARCB1
37 olfactory nerve neoplasm 10.2 ENO2 SYP
38 cerebral neuroblastoma 10.2 ENO2 SYP
39 benign ependymoma 10.2 ENO2 SYP
40 malignant teratoma 10.2 ENO2 SYP
41 astroblastoma 10.2 ENO2 SYP
42 pineal gland cancer 10.2 ENO2 SYP
43 endometrial small cell carcinoma 10.2 ENO2 SYP
44 melanotic neuroectodermal tumor 10.2 ENO2 SYP
45 nodular ganglioneuroblastoma 10.2 ENO2 SYP
46 mucinous ovarian cystadenoma 10.2 ENO2 SYP
47 pineocytoma 10.2 ENO2 SYP
48 respiratory system benign neoplasm 10.2 ENO2 SYP
49 synovium cancer 10.2 EWSR1 SMARCB1
50 angiomyoma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Extraosseous Chondrosarcoma:



Diseases related to Extraosseous Chondrosarcoma

Symptoms & Phenotypes for Extraosseous Chondrosarcoma

Drugs & Therapeutics for Extraosseous Chondrosarcoma

Drugs for Extraosseous Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
3
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
7 Alkylating Agents Phase 3,Phase 2
8 Antineoplastic Agents, Alkylating Phase 3,Phase 2
9
Isophosphamide mustard Phase 3,Phase 2 0
10 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
11 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
12 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
13
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
16
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
17
Gemcitabine Approved Phase 2 95058-81-4 60750
18 insulin Phase 2
19 Mitogens Phase 2
20 Angiogenesis Inhibitors Phase 2
21 Angiogenesis Modulating Agents Phase 2
22 Antibodies Phase 2,Phase 1
23 Immunoglobulins Phase 2,Phase 1
24 Antibodies, Monoclonal Phase 2,Phase 1
25 Immunosuppressive Agents Phase 2
26 Insulin, Globin Zinc Phase 2
27 Anti-Infective Agents Phase 2
28 Antimetabolites Phase 2
29 Antiviral Agents Phase 2
30 Antimetabolites, Antineoplastic Phase 2
31 lysine Nutraceutical Phase 2,Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
3 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Unknown status NCT02066285 Phase 2 Pazopanib
6 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
7 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
8 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
9 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
10 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
11 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
12 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
13 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
14 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
15 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Active, not recruiting NCT00589121 Phase 2 Chemotherapy
16 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
17 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
18 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Active, not recruiting NCT02601937 Phase 1 Tazemetostat
19 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211

Search NIH Clinical Center for Extraosseous Chondrosarcoma

Genetic Tests for Extraosseous Chondrosarcoma

Anatomical Context for Extraosseous Chondrosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Extraosseous Chondrosarcoma:

19
Exclusively Soft Tissue

MalaCards organs/tissues related to Extraosseous Chondrosarcoma:

41
Brain

Publications for Extraosseous Chondrosarcoma

Articles related to Extraosseous Chondrosarcoma:

# Title Authors Year
1
N-acetyl aspartate peak in extra-axial extraosseous chondrosarcoma of the brain on MRI: Unravelling a diagnostic dilemma. ( 26755017 )
2016
2
Interesting image. Maffucci syndrome with extraosseous chondrosarcoma imaged with F-18 FDG PET-CT. ( 20026970 )
2010
3
Well-differentiated extraosseous chondrosarcoma of the foot with pulmonary metastases. ( 16084955 )
2005
4
Extraosseous chondrosarcoma of the wrist: a case report. ( 6725890 )
1984
5
Extraosseous chondrosarcoma of the maxilla. ( 16097305 )
1967
6
Extraosseous chondrosarcoma arising from the tendon Achilles. ( 13862257 )
1961

Variations for Extraosseous Chondrosarcoma

Expression for Extraosseous Chondrosarcoma

Search GEO for disease gene expression data for Extraosseous Chondrosarcoma.

Pathways for Extraosseous Chondrosarcoma

Pathways related to Extraosseous Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 EWSR1 FUS TAF15
2 11.33 EWSR1 FUS SMARCB1 TAF15

GO Terms for Extraosseous Chondrosarcoma

Molecular functions related to Extraosseous Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coregulator activity GO:0003712 8.8 EWSR1 FUS TAF15

Sources for Extraosseous Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....