MCID: EXT030
MIFTS: 29

Extraosseous Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Extraosseous Chondrosarcoma

MalaCards integrated aliases for Extraosseous Chondrosarcoma:

Name: Extraosseous Chondrosarcoma 12 15
Extraskeletal Myxoid Chondrosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4549
UMLS 73 C1275278

Summaries for Extraosseous Chondrosarcoma

Disease Ontology : 12 A chondrosarcoma that is located in exclusively soft tissue.

MalaCards based summary : Extraosseous Chondrosarcoma, also known as extraskeletal myxoid chondrosarcoma, is related to chondrosarcoma, extraskeletal myxoid and chondrosarcoma. An important gene associated with Extraosseous Chondrosarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and skin.

Related Diseases for Extraosseous Chondrosarcoma

Diseases in the Extraosseous Chondrosarcoma family:

Adult Extraosseous Chondrosarcoma

Diseases related to Extraosseous Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma, extraskeletal myxoid 31.2 ENO2 EWSR1 FUS SMARCB1 SNRPC SYP
2 chondrosarcoma 30.5 ENO2 EWSR1 TAF15 TFG
3 adult extraosseous chondrosarcoma 12.3
4 extraskeletal mesenchymal chondrosarcoma 11.3
5 myxoid chondrosarcoma 10.2 EWSR1 TAF15
6 pediatric fibrosarcoma 10.2 EWSR1 TFG
7 cellular myxoid liposarcoma 10.2 EWSR1 FUS
8 myxoid liposarcoma 10.2 EWSR1 FUS
9 juxtacortical chondroma 10.2 EWSR1 FUS
10 small cell osteogenic sarcoma 10.2 ENO2 EWSR1
11 askin's tumor 10.2 ENO2 EWSR1
12 bone ewing's sarcoma 10.1 ENO2 EWSR1
13 chondroid lipoma 10.1 ENO2 FUS
14 extraosseous ewing's sarcoma 10.1 ENO2 EWSR1
15 muscle cancer 10.1 ENO2 EWSR1
16 fibrous histiocytoma 10.1 EWSR1 FUS
17 skin sarcoma 10.1 EWSR1 SYP
18 histiocytoma 10.1 EWSR1 FUS
19 carotid body cancer 10.1 ENO2 SYP
20 malignant sertoli cell tumor 10.1 ENO2 SYP
21 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
22 large cell carcinoma 10.1 ENO2 SYP
23 auditory system cancer 10.1 ENO2 SYP
24 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
25 gallbladder small cell carcinoma 10.1 ENO2 SYP
26 small cell carcinoma 10.1 ENO2 SYP
27 pancreatic somatostatinoma 10.1 ENO2 SYP
28 cutaneous ganglioneuroma 10.1 ENO2 SYP
29 ganglioneuroma 10.1 ENO2 SYP
30 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
31 small cell carcinoma of the bladder 10.1 ENO2 SYP
32 papillary tumor of the pineal region 10.1 ENO2 SYP
33 sensory organ benign neoplasm 10.1 ENO2 SYP
34 orbital cancer 10.1 ENO2 SYP
35 middle ear adenoma 10.1 ENO2 SYP
36 multiple enchondromatosis, maffucci type 10.1
37 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP
38 large cell neuroendocrine carcinoma 10.1 ENO2 SYP
39 atypical follicular adenoma 10.1 ENO2 SYP
40 central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
41 cerebellum cancer 10.1 ENO2 SYP
42 clear cell ependymoma 10.1 ENO2 SYP
43 ependymoma 10.1 ENO2 SYP
44 vulvar sarcoma 10.1 EWSR1 SMARCB1
45 cerebral neuroblastoma 10.1 ENO2 SYP
46 endometrial small cell carcinoma 10.1 ENO2 SYP
47 subependymal glioma 10.1 ENO2 SYP
48 malignant teratoma 10.1 ENO2 SYP
49 astroblastoma 10.1 ENO2 SYP
50 olfactory nerve neoplasm 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Extraosseous Chondrosarcoma:



Diseases related to Extraosseous Chondrosarcoma

Symptoms & Phenotypes for Extraosseous Chondrosarcoma

Drugs & Therapeutics for Extraosseous Chondrosarcoma

Drugs for Extraosseous Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
5
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
6
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
7 Antineoplastic Agents, Alkylating Phase 3,Phase 2
8 Alkylating Agents Phase 3,Phase 2
9
Isophosphamide mustard Phase 3,Phase 2 0
10 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
11 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
12 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
13
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Allopurinol Approved Phase 2 315-30-0 2094
16
Loperamide Approved Phase 2 53179-11-6 3955
17
Mecasermin Approved, Investigational Phase 2 68562-41-4
18
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
19
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
20
Gemcitabine Approved Phase 2 95058-81-4 60750
21 Antidiarrheals Phase 2
22 Free Radical Scavengers Phase 2
23 Antimetabolites Phase 2
24 Antioxidants Phase 2
25 Antiemetics Phase 2
26 Gastrointestinal Agents Phase 2
27 Antirheumatic Agents Phase 2
28 Autonomic Agents Phase 2
29 Protective Agents Phase 2
30 Peripheral Nervous System Agents Phase 2
31 Mitogens Phase 2
32 Insulin, Globin Zinc Phase 2
33 Antibodies, Monoclonal Phase 2,Phase 1
34 Immunoglobulins Phase 2,Phase 1
35 insulin Phase 2
36 Antibodies Phase 2,Phase 1
37 Immunosuppressive Agents Phase 2
38 Angiogenesis Modulating Agents Phase 2
39 Angiogenesis Inhibitors Phase 2
40 lysine Phase 2,Phase 1
41 Antiviral Agents Phase 2
42 Antimetabolites, Antineoplastic Phase 2
43 Anti-Infective Agents Phase 2
44 Immunologic Factors Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Unknown status NCT02066285 Phase 2 Pazopanib
6 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
7 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
8 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
9 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
10 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
11 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Completed NCT00589121 Phase 2 Chemotherapy
12 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
13 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
14 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
15 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
16 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
17 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
18 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Active, not recruiting NCT02601937 Phase 1 Tazemetostat
19 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211

Search NIH Clinical Center for Extraosseous Chondrosarcoma

Genetic Tests for Extraosseous Chondrosarcoma

Anatomical Context for Extraosseous Chondrosarcoma

MalaCards organs/tissues related to Extraosseous Chondrosarcoma:

41
Brain, Lung, Skin, Kidney, Bone, Pineal, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Extraosseous Chondrosarcoma:

19
Exclusively Soft Tissue

Publications for Extraosseous Chondrosarcoma

Articles related to Extraosseous Chondrosarcoma:

(show all 21)
# Title Authors Year
1
Extraskeletal Myxoid Chondrosarcoma of Nasopharynx: An Oncologic Entity Rarely Reported. ( 29657686 )
2018
2
Intraluminal EWSR1-CREB1 gene rearranged, low-grade myxoid sarcoma of the pulmonary artery resembling extraskeletal myxoid chondrosarcoma (EMC). ( 30326150 )
2018
3
Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features. ( 30353688 )
2018
4
Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases. ( 30534357 )
2018
5
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
6
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. ( 28187993 )
2017
7
N-acetyl aspartate peak in extra-axial extraosseous chondrosarcoma of the brain on MRI: Unravelling a diagnostic dilemma. ( 26755017 )
2016
8
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
9
Extraskeletal myxoid chondrosarcoma of the left buccal mucosa. ( 22843913 )
2012
10
Intracranial extraskeletal myxoid chondrosarcoma : case report and literature review. ( 23115670 )
2012
11
Primary extraskeletal myxoid chondrosarcoma of the vulva. ( 21651669 )
2011
12
Interesting image. Maffucci syndrome with extraosseous chondrosarcoma imaged with F-18 FDG PET-CT. ( 20026970 )
2010
13
Extraskeletal myxoid chondrosarcoma: a case report of complete remission by chemotherapy and review of the literature. ( 22315646 )
2010
14
Skeletal recurrences and metastases of extraskeletal myxoid chondrosarcoma. ( 17437101 )
2007
15
Well-differentiated extraosseous chondrosarcoma of the foot with pulmonary metastases. ( 16084955 )
2005
16
Effusion cytology of metastatic extraskeletal myxoid chondrosarcoma. ( 12672100 )
2003
17
Skeletal and extraskeletal myxoid chondrosarcoma: a comparative clinicopathologic, ultrastructural, and molecular study. ( 9781944 )
1998
18
Unusual extraskeletal myxoid chondrosarcoma in a child. ( 2323742 )
1990
19
Extraosseous chondrosarcoma of the wrist: a case report. ( 6725890 )
1984
20
Extraosseous chondrosarcoma of the maxilla. ( 16097305 )
1967
21
Extraosseous chondrosarcoma arising from the tendon Achilles. ( 13862257 )
1961

Variations for Extraosseous Chondrosarcoma

Expression for Extraosseous Chondrosarcoma

Search GEO for disease gene expression data for Extraosseous Chondrosarcoma.

Pathways for Extraosseous Chondrosarcoma

Pathways related to Extraosseous Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 EWSR1 FUS TAF15
2 11.33 EWSR1 FUS SMARCB1 TAF15

GO Terms for Extraosseous Chondrosarcoma

Sources for Extraosseous Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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