MCID: EXT030
MIFTS: 34

Extraosseous Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Extraosseous Chondrosarcoma

MalaCards integrated aliases for Extraosseous Chondrosarcoma:

Name: Extraosseous Chondrosarcoma 12 15
Extraskeletal Myxoid Chondrosarcoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4549
UMLS 74 C1275278

Summaries for Extraosseous Chondrosarcoma

Disease Ontology : 12 A chondrosarcoma that is located in exclusively soft tissue.

MalaCards based summary : Extraosseous Chondrosarcoma, also known as extraskeletal myxoid chondrosarcoma, is related to chondrosarcoma and chondrosarcoma, extraskeletal myxoid. An important gene associated with Extraosseous Chondrosarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, pineal and lung.

Related Diseases for Extraosseous Chondrosarcoma

Diseases in the Extraosseous Chondrosarcoma family:

Adult Extraosseous Chondrosarcoma

Diseases related to Extraosseous Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.6 ENO2 EWSR1 TAF15 TFG
2 chondrosarcoma, extraskeletal myxoid 30.5 ENO2 EWSR1 FUS SMARCB1 SNRPC SYP
3 adult extraosseous chondrosarcoma 12.3
4 extraskeletal mesenchymal chondrosarcoma 11.3
5 myxoid chondrosarcoma 10.4 EWSR1 TAF15
6 pediatric fibrosarcoma 10.3 EWSR1 TFG
7 small cell osteogenic sarcoma 10.3 ENO2 EWSR1
8 askin's tumor 10.3 ENO2 EWSR1
9 cellular myxoid liposarcoma 10.3 EWSR1 FUS
10 myxoid liposarcoma 10.3 EWSR1 FUS
11 juxtacortical chondroma 10.3 EWSR1 FUS
12 bone ewing's sarcoma 10.3 ENO2 EWSR1
13 carotid body cancer 10.2 ENO2 SYP
14 chondroid lipoma 10.2 ENO2 FUS
15 malignant sertoli cell tumor 10.2 ENO2 SYP
16 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
17 large cell carcinoma 10.2 ENO2 SYP
18 auditory system cancer 10.2 ENO2 SYP
19 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
20 pancreatic somatostatinoma 10.2 ENO2 SYP
21 cutaneous ganglioneuroma 10.2 ENO2 SYP
22 ganglioneuroma 10.2 ENO2 SYP
23 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
24 small cell carcinoma 10.2 ENO2 SYP
25 small cell carcinoma of the bladder 10.2 ENO2 SYP
26 papillary tumor of the pineal region 10.2 ENO2 SYP
27 sensory organ benign neoplasm 10.2 ENO2 SYP
28 orbital cancer 10.2 ENO2 SYP
29 middle ear adenoma 10.2 ENO2 SYP
30 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
31 large cell neuroendocrine carcinoma 10.2 ENO2 SYP
32 vulvar sarcoma 10.2 EWSR1 SMARCB1
33 gallbladder small cell carcinoma 10.2 ENO2 SYP
34 atypical follicular adenoma 10.2 ENO2 SYP
35 extraosseous ewing's sarcoma 10.2 ENO2 EWSR1
36 central nervous system primitive neuroectodermal neoplasm 10.2 ENO2 SYP
37 cerebellum cancer 10.2 ENO2 SYP
38 clear cell ependymoma 10.2 ENO2 SYP
39 ependymoma 10.2 ENO2 SYP
40 cerebral neuroblastoma 10.2 ENO2 SYP
41 endometrial small cell carcinoma 10.2 ENO2 SYP
42 subependymal glioma 10.2 ENO2 SYP
43 malignant teratoma 10.2 ENO2 SYP
44 astroblastoma 10.2 ENO2 SYP
45 olfactory nerve neoplasm 10.2 ENO2 SYP
46 pineal gland cancer 10.2 ENO2 SYP
47 autonomic nervous system benign neoplasm 10.2 ENO2 SYP
48 melanotic neuroectodermal tumor 10.2 ENO2 SYP
49 benign ependymoma 10.2 ENO2 SYP
50 skin sarcoma 10.2 EWSR1 SYP

Graphical network of the top 20 diseases related to Extraosseous Chondrosarcoma:



Diseases related to Extraosseous Chondrosarcoma

Symptoms & Phenotypes for Extraosseous Chondrosarcoma

Drugs & Therapeutics for Extraosseous Chondrosarcoma

Drugs for Extraosseous Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
7
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
8 Alkylating Agents Phase 3,Phase 2
9 Antineoplastic Agents, Alkylating Phase 3,Phase 2
10 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
11 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
12 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
13
Isophosphamide mustard Phase 3,Phase 2 0
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Loperamide Approved Phase 2 53179-11-6 3955
16
Allopurinol Approved Phase 2 315-30-0 2094
17
Mecasermin Approved, Investigational Phase 2 68562-41-4
18
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
19
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
20
Gemcitabine Approved Phase 2 95058-81-4 60750
21 Autonomic Agents Phase 2
22 Protective Agents Phase 2
23 Free Radical Scavengers Phase 2
24 Antidiarrheals Phase 2
25 Antiemetics Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Antimetabolites Phase 2
28 Antioxidants Phase 2
29 Gastrointestinal Agents Phase 2
30 Antirheumatic Agents Phase 2
31 insulin Phase 2
32 Immunoglobulins Phase 2,Phase 1
33 Mitogens Phase 2
34 Antibodies Phase 2,Phase 1
35 Antibodies, Monoclonal Phase 2,Phase 1
36 Insulin, Globin Zinc Phase 2
37 Angiogenesis Modulating Agents Phase 2
38 Angiogenesis Inhibitors Phase 2
39 Immunosuppressive Agents Phase 2
40 Protein Kinase Inhibitors Phase 2
41 lysine Phase 2,Phase 1
42 Anti-Infective Agents Phase 2
43 Immunologic Factors Phase 2
44 Antiviral Agents Phase 2
45 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Completed NCT00423618 Phase 3
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Trial of Pazopanib in Patients With Solitary Fibrous Tumor and Extraskeletal Myxoid Chondrosarcoma Unknown status NCT02066285 Phase 2 Pazopanib
6 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
7 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine
8 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
9 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
10 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
11 Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Completed NCT00589121 Phase 2 Chemotherapy
12 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
13 Proton or Photon RT for Retroperitoneal Sarcomas Recruiting NCT01659203 Phase 1, Phase 2
14 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2 Tazemetostat
15 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
16 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
17 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
18 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1 Tazemetostat
19 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211

Search NIH Clinical Center for Extraosseous Chondrosarcoma

Genetic Tests for Extraosseous Chondrosarcoma

Anatomical Context for Extraosseous Chondrosarcoma

MalaCards organs/tissues related to Extraosseous Chondrosarcoma:

42
Bone, Pineal, Lung, Cerebellum, Brain, Kidney, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Extraosseous Chondrosarcoma:

20
Exclusively Soft Tissue

Publications for Extraosseous Chondrosarcoma

Articles related to Extraosseous Chondrosarcoma:

(show top 50) (show all 194)
# Title Authors Year
1
Systemic manifestations of extraskeletal myxoid chondrosarcoma associated with a novel t(2;22)(q34;q12) EWS translocation in a child and a review of the literature. ( 30776935 )
2019
2
A 5-year follow-up of vulval swelling due to extraskeletal myxoid chondrosarcoma: A rare case report. ( 30967942 )
2019
3
Extraskeletal myxoid chondrosarcoma of the leg in a child: A case report. ( 30985717 )
2019
4
Intraluminal EWSR1-CREB1 gene rearranged, low-grade myxoid sarcoma of the pulmonary artery resembling extraskeletal myxoid chondrosarcoma (EMC). ( 30326150 )
2019
5
A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma. ( 28187993 )
2019
6
Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases. ( 30534357 )
2018
7
Extraskeletal Myxoid Chondrosarcoma of Nasopharynx: An Oncologic Entity Rarely Reported. ( 29657686 )
2018
8
Molecular and Clinicopathologic Heterogeneity of Intracranial Tumors Mimicking Extraskeletal Myxoid Chondrosarcoma. ( 29924341 )
2018
9
Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma. ( 29937513 )
2018
10
Extraskeletal Myxoid Chondrosarcoma: A Comparative Study of Imaging and Pathology. ( 29977924 )
2018
11
Fine-needle aspiration features of extraskeletal myxoid chondrosarcoma: A study of cytological and molecular features. ( 30353688 )
2018
12
INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. ( 29327709 )
2018
13
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma: A Propensity Score Weighted Population-based Analysis of the SEER Database. ( 27819877 )
2018
14
Extraskeletal myxoid chondrosarcoma of the masticator space in a pediatric patient. ( 28638563 )
2017
15
Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma. ( 29110880 )
2017
16
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review. ( 29381948 )
2017
17
Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review: Erratum. ( 29390404 )
2017
18
Extraskeletal Myxoid Chondrosarcoma of the Foot Clinically Mimicking Plantar Fibromatosis. ( 27655120 )
2017
19
Primary extraskeletal myxoid chondrosarcoma of bone: Report of three cases and review of the literature. ( 28249774 )
2017
20
Curious case of extraskeletal myxoid chondrosarcoma. ( 28360467 )
2017
21
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma. ( 28383167 )
2017
22
Next generation sequencing of extraskeletal myxoid chondrosarcoma. ( 28423517 )
2017
23
Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review. ( 27402218 )
2016
24
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
25
Pulmonary extraskeletal myxoid chondrosarcoma: A case report and literature review. ( 27591381 )
2016
26
Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. ( 27832806 )
2016
27
N-acetyl aspartate peak in extra-axial extraosseous chondrosarcoma of the brain on MRI: Unravelling a diagnostic dilemma. ( 26755017 )
2016
28
Extraskeletal Myxoid Chondrosarcoma of the Orbit. ( 27162461 )
2016
29
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity. ( 27194880 )
2016
30
Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. ( 26434451 )
2015
31
Paravertebral extraskeletal myxoid chondrosarcoma: a case report and review of the literature. ( 26448808 )
2015
32
Extraskeletal Myxoid Chondrosarcoma Presenting as a Plantar Fibroma: Case Report and Review of the Literature. ( 26504046 )
2015
33
Extraskeletal myxoid chondrosarcoma of the vulva: A case report. ( 26622802 )
2015
34
Unresectable Extraskeletal Myxoid Chondrosarcoma of the Neck: Early Tumor Response to Chemoradiotherapy. ( 26848421 )
2015
35
Primary extraskeletal myxoid chondrosarcoma of pulmonary arteries: a rare mimic of acute pulmonary thromboembolism. ( 25564577 )
2015
36
Breast Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report. ( 26125202 )
2015
37
Extraskeletal myxoid chondrosarcoma of the thigh in a child: a case report. ( 25550031 )
2014
38
Extraskeletal myxoid chondrosarcoma presenting as an intradural spinal mass: report of a rare clinical presentation with an emphasis on differential diagnostic considerations. ( 25568751 )
2014
39
Extraskeletal myxoid chondrosarcoma arising in the femoral vein: a case report. ( 24818862 )
2014
40
Extraskeletal myxoid chondrosarcoma: A report of two cases. ( 24944710 )
2014
41
Extraskeletal myxoid chondrosarcoma with a t(9;16)(q22;p11.2) resulting in a NR4A3-FUS fusion. ( 25130955 )
2014
42
Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases. ( 25177237 )
2014
43
Extraskeletal myxoid chondrosarcoma of the vulva with PLAG1 gene activation: molecular genetic characterization of 2 cases. ( 24185117 )
2014
44
Diagnostic utility of molecular investigation in extraskeletal myxoid chondrosarcoma. ( 24508382 )
2014
45
Activity of sunitinib in extraskeletal myxoid chondrosarcoma. ( 24703573 )
2014
46
Extraskeletal myxoid chondrosarcoma with non-EWSR1-NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology. ( 24746215 )
2014
47
Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study. ( 24345066 )
2013
48
Extraskeletal myxoid chondrosarcoma of the neck. ( 23230139 )
2013
49
Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone. ( 23588370 )
2013
50
Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib. ( 23058004 )
2012

Variations for Extraosseous Chondrosarcoma

Expression for Extraosseous Chondrosarcoma

Search GEO for disease gene expression data for Extraosseous Chondrosarcoma.

Pathways for Extraosseous Chondrosarcoma

Pathways related to Extraosseous Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 EWSR1 FUS TAF15
2 11.33 EWSR1 FUS SMARCB1 TAF15

GO Terms for Extraosseous Chondrosarcoma

Molecular functions related to Extraosseous Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 8.8 FUS NKX2-2 SMARCB1

Sources for Extraosseous Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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