MCID: EXT032
MIFTS: 37

Extraosseous Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Extraosseous Osteosarcoma

MalaCards integrated aliases for Extraosseous Osteosarcoma:

Name: Extraosseous Osteosarcoma 12 15
Extraskeletal Osteosarcoma 12 73
Extraskeletal Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3357
NCIt 50 C8810
UMLS 73 C0855052

Summaries for Extraosseous Osteosarcoma

MalaCards based summary : Extraosseous Osteosarcoma, also known as extraskeletal osteosarcoma, is related to adult extraosseous osteosarcoma and childhood extraosseous osteosarcoma, and has symptoms including pain An important gene associated with Extraosseous Osteosarcoma is SP7 (Sp7 Transcription Factor), and among its related pathways/superpathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Pyrimidine metabolism. The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Extraosseous Osteosarcoma

Diseases in the Extraosseous Osteosarcoma family:

Adult Extraosseous Osteosarcoma

Diseases related to Extraosseous Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 adult extraosseous osteosarcoma 12.5
2 childhood extraosseous osteosarcoma 12.3
3 mediastinal osteogenic sarcoma 11.6
4 kidney osteogenic sarcoma 11.3
5 hepatic osteogenic sarcoma 11.3
6 breast osteosarcoma 11.3
7 osteogenic sarcoma 10.7
8 sarcoma 10.7
9 juxtacortical osteosarcoma 10.2
10 myositis 10.2
11 chondrosarcoma 10.2
12 myositis ossificans 10.2
13 wilms tumor 6 10.1
14 ossifying fibromyxoid tumor 10.0
15 degos 'en cocarde' erythrokeratoderma 10.0
16 lipomatosis, multiple 10.0
17 alveolar soft part sarcoma 10.0
18 burn scar 10.0
19 infective endocarditis 10.0
20 pleomorphic lipoma 10.0
21 endocarditis 10.0
22 hydronephrosis 10.0
23 patulous eustachian tube 10.0
24 tarsal tunnel syndrome 10.0
25 keratosis 10.0
26 thyroid cancer 10.0
27 calcinosis 10.0
28 malignant fibroxanthoma 10.0
29 adenocarcinoma 10.0
30 histiocytoma 10.0
31 clear cell sarcoma 10.0
32 spindle cell sarcoma 10.0
33 fibrous histiocytoma 10.0
34 actinic keratosis 10.0
35 germ cells tumors 10.0
36 osteochondroma 10.0
37 undifferentiated pleomorphic sarcoma 10.0
38 conventional central osteosarcoma 10.0 MDM2 SPARC
39 bone osteosarcoma 10.0 MDM2 SPARC
40 osteogenesis imperfecta, type iv 10.0 SP7 SPARC
41 periosteal osteogenic sarcoma 10.0 MDM2 SPARC
42 peripheral osteosarcoma 10.0 MDM2 SPARC
43 uterine sarcoma 9.8 DCK MDM2
44 pancreas adenocarcinoma 9.7 DCK SPARC

Graphical network of the top 20 diseases related to Extraosseous Osteosarcoma:



Diseases related to Extraosseous Osteosarcoma

Symptoms & Phenotypes for Extraosseous Osteosarcoma

UMLS symptoms related to Extraosseous Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.17 SPARC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.17 SP7
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.17 SP7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.17 SPARC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.17 SP7 SPARC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.17 SPARC

Drugs & Therapeutics for Extraosseous Osteosarcoma

Drugs for Extraosseous Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
6
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
7
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
8
Isophosphamide mustard Phase 3,Phase 2 0
9 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
10 Antineoplastic Agents, Alkylating Phase 3,Phase 2
11 Alkylating Agents Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
13 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
14 Etoposide phosphate Phase 3
15 Antineoplastic Agents, Phytogenic Phase 3
16
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
17
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
18
Gemcitabine Approved Phase 2 95058-81-4 60750
19 Immunosuppressive Agents Phase 2
20 Angiogenesis Modulating Agents Phase 2
21 Angiogenesis Inhibitors Phase 2
22 Antimetabolites Phase 2
23 Antiviral Agents Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Anti-Infective Agents Phase 2
26 Immunologic Factors Phase 2
27 Antibodies, Monoclonal Phase 1
28 Immunoglobulins Phase 1
29 Antibodies Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
6 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
7 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
8 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
9 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
10 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride

Search NIH Clinical Center for Extraosseous Osteosarcoma

Genetic Tests for Extraosseous Osteosarcoma

Anatomical Context for Extraosseous Osteosarcoma

MalaCards organs/tissues related to Extraosseous Osteosarcoma:

41
Bone, Lung, Liver, Breast, Thyroid, Kidney, Pancreas

Publications for Extraosseous Osteosarcoma

Articles related to Extraosseous Osteosarcoma:

(show top 50) (show all 215)
# Title Authors Year
1
A Rare Extraskeletal Osteosarcoma Appearing After 55 Years on a Large Stage 3 Burn Scar. ( 29971170 )
2018
2
A case of primary extraskeletal osteosarcoma of the breast. ( 30232644 )
2018
3
18F-FDG PET/CT in Isolated Primary Extraskeletal Osteosarcoma. ( 30273208 )
2018
4
Primary Extraskeletal Osteosarcoma Arising from the Optic Nerve: A Rare Case Report. ( 30320102 )
2018
5
Extraskeletal osteosarcoma in right neck subcutaneous tissue: A case report of an extremely rare tumour. ( 30101012 )
2018
6
Extraskeletal osteosarcoma arising in the subcutaneous tissue of the lower leg: A case report and literature review. ( 30112173 )
2018
7
Pancreatic Extraskeletal Osteosarcoma Metastasizing to the Scalp. ( 29853753 )
2018
8
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity. ( 29489027 )
2018
9
Clinical, radiological, and pathological features of extraskeletal osteosarcoma. ( 29502131 )
2018
10
Extraskeletal osteosarcoma of the lung following treatment of primary small-cell lung carcinoma with chemoradiotherapy: A case report. ( 29399350 )
2018
11
A primary extraskeletal osteosarcoma of the mesentery: a case report. ( 28434377 )
2018
12
Extraskeletal Osteosarcoma: Outcomes and the Role of Chemotherapy. ( 28622153 )
2018
13
Extraskeletal osteosarcoma in the parotid gland: A case report. ( 28947094 )
2018
14
Extraskeletal Osteosarcoma of the Hand. ( 29032283 )
2018
15
Extraskeletal osteosarcoma arising in myositis ossificans: a case report and review of the literature. ( 28536749 )
2017
16
Anterior abdominal wall extraosseous osteosarcoma, occurring 40 years after para-aortic irradiation. ( 28645924 )
2017
17
Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. ( 28235629 )
2017
18
Rare Dual Lesion: Extraskeletal Osteosarcoma Developing Within a Simple Lipoma. ( 28666052 )
2017
19
Primary thoracic extraskeletal osteosarcoma: a case report and literature review. ( 29312772 )
2017
20
Extraskeletal osteosarcoma: A European Musculoskeletal Oncology Society study on 266 patients. ( 28167373 )
2017
21
Tumor lysis syndrome in an extraskeletal osteosarcoma: a case report and review of the literature. ( 28335813 )
2017
22
A Case Report on Extraskeletal Osteosarcoma. ( 28384952 )
2017
23
Extraskeletal Osteosarcoma Arising from the Pleura. ( 28551716 )
2017
24
Subcutaneous extraskeletal osteosarcoma in a metatarsal footpad in a cat. ( 28627100 )
2017
25
Sarcomatoid Carcinoma Manifesting as Recurrent Rectal Cancer and Mimicking Radiation-Induced Extraskeletal Osteosarcoma: A Case Report. ( 28633587 )
2017
26
Outcome following treatment of soft tissue and visceral extraskeletal osteosarcoma in 33 dogs: 2008-2013. ( 25643914 )
2017
27
Treatment of extraskeletal osteosarcoma at a previous injection site resulting in prolonged survival in 1 dog. ( 27587886 )
2016
28
Osteoblastic Extraosseous Osteosarcoma of the Neck. ( 27914228 )
2016
29
Extraosseous Osteosarcoma of the Liver Demonstrated on 18F-FDG PET/CT Imaging. ( 27055145 )
2016
30
Large Retroperitoneal Extraosseous Osteosarcoma Invading into the Spine: a Case Report. ( 27872537 )
2016
31
Pulmonary metastasised extraskeletal osteosarcoma. ( 26347392 )
2016
32
A Rare Pediatric Example of Subcutaneous Extraskeletal Osteosarcoma: A Case Report and Review of the Morphologic Differential Diagnosis. ( 26460626 )
2016
33
Extraskeletal Osteosarcoma- A Case Report. ( 26894075 )
2016
34
Spontaneous extraskeletal osteosarcoma with various histological growth patterns in the abdominal wall of an ICR mouse. ( 26989300 )
2016
35
Subcutaneous extraskeletal osteosarcoma of the forearm: a case report and review of the literature. ( 27357312 )
2016
36
Fibro-Osseous Pseudotumor of the Digit: A Diagnostic Pitfall of Extraskeletal Osteosarcoma. ( 27489434 )
2016
37
The molecular landscape of extraskeletal osteosarcoma: A clinicopathological and molecular biomarker study. ( 27499911 )
2016
38
The Treatment and Outcomes of Extraskeletal Osteosarcoma: Institutional Experience and Review of The Literature. ( 27528844 )
2016
39
Concurrent Nontuberculous Mycobacteria Infection and High-Grade Anterior Mediastinal Extraskeletal Osteosarcoma (ESOS): Is There a Connection? ( 27539718 )
2016
40
Spontaneous extraskeletal osteosarcoma in the duodenum of a Crlj:CD1 (ICR) mouse. ( 27821914 )
2016
41
Extraskeletal osteosarcoma of the orbit: A clinicopathologic case report and review of literature. ( 27853024 )
2016
42
Extraskeletal osteosarcoma in the back. ( 28757717 )
2016
43
Postradiation Extraskeletal Osteosarcoma Masquerading as an Axillary Artery Pseudoaneurysm. ( 26291499 )
2016
44
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas? ( 26197952 )
2015
45
CORR Insights(Ar): Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas? ( 26310679 )
2015
46
Extraskeletal Osteosarcoma of the Omentum with Aggressive Development. ( 26305205 )
2015
47
Extraskeletal Osteosarcoma Induced by a Foreign Body Granuloma. ( 26355582 )
2015
48
Extraskeletal osteosarcoma of the hand: the role of marginal excision and adjuvant radiation therapy. ( 26568711 )
2015
49
Primary extraskeletal osteosarcoma of gall bladder. ( 27509713 )
2015
50
Extraskeletal osteosarcoma in Norway, between 1975 and 2009, and a brief review of the literature. ( 25862869 )
2015

Variations for Extraosseous Osteosarcoma

Expression for Extraosseous Osteosarcoma

Search GEO for disease gene expression data for Extraosseous Osteosarcoma.

Pathways for Extraosseous Osteosarcoma

GO Terms for Extraosseous Osteosarcoma

Biological processes related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 8.96 MDM2 SPARC
2 pyrimidine nucleoside salvage GO:0043097 8.62 CDA DCK

Sources for Extraosseous Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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