MCID: EXT032
MIFTS: 31

Extraosseous Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Extraosseous Osteosarcoma

MalaCards integrated aliases for Extraosseous Osteosarcoma:

Name: Extraosseous Osteosarcoma 12 15
Extraskeletal Osteosarcoma 12 70
Extraskeletal Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3357
NCIt 50 C8810
SNOMED-CT 67 404077005
UMLS 70 C0855052

Summaries for Extraosseous Osteosarcoma

MalaCards based summary : Extraosseous Osteosarcoma, also known as extraskeletal osteosarcoma, is related to osteogenic sarcoma and malignant fibrous histiocytoma, and has symptoms including pain An important gene associated with Extraosseous Osteosarcoma is SPARC (Secreted Protein Acidic And Cysteine Rich), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Oncogene Induced Senescence. Affiliated tissues include bone, heart and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Extraosseous Osteosarcoma

Diseases in the Extraosseous Osteosarcoma family:

Adult Extraosseous Osteosarcoma

Diseases related to Extraosseous Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 osteogenic sarcoma 30.8 SPARC SP7 MDM2 CDK4 BGLAP
2 malignant fibrous histiocytoma 30.6 MDM2 CDK4 CD68
3 juxtacortical osteosarcoma 30.6 SATB2 MDM2 CDK4
4 chondrosarcoma 30.4 SPARC MDM2 CDK4
5 myositis ossificans 30.3 SPARC SATB2 MDM2 CDK4 BGLAP
6 exophthalmos 30.2 CD68 CD34
7 malignant mesenchymoma 30.1 MDM2 CD34 CALD1
8 pleomorphic lipoma 30.1 MDM2 CDK4 CD68 CD34
9 liposarcoma 30.1 MDM2 CDK4 CD68 CD34
10 bone sarcoma 30.1 MDM2 CDK4 BGLAP
11 osteoblastoma 30.0 SPARC SATB2 BGLAP
12 spindle cell sarcoma 30.0 SSX1 MDM2 CD34 CALD1
13 lipomatosis, multiple 29.6 MDM2 CDK4 CD34 CALD1
14 bone osteosarcoma 29.6 SPARC SATB2 MDM2 CDK4 BGLAP
15 dedifferentiated liposarcoma 29.4 MDM2 CDK4 CD34 CALD1
16 mediastinal osteogenic sarcoma 11.2
17 childhood extraosseous osteosarcoma 11.2
18 adult extraosseous osteosarcoma 11.2
19 kidney osteogenic sarcoma 11.2
20 hepatic osteogenic sarcoma 11.2
21 breast osteosarcoma 11.2
22 sarcoma 10.4
23 myositis 10.4
24 soft tissue sarcoma 10.3
25 ring chromosome 7 10.3 MDM2 CDK4
26 ring chromosome 10.3 MDM2 CDK4
27 mediastinum liposarcoma 10.3 MDM2 CDK4
28 undifferentiated embryonal sarcoma of the liver 10.3 MDM2 CDK4
29 embryonal sarcoma 10.3 MDM2 CDK4
30 diffuse lipomatosis 10.3 MDM2 CDK4
31 aortic malignant tumor 10.3 MDM2 CD34
32 lipoblastoma 10.3 MDM2 CDK4
33 fibrosarcomatous osteosarcoma 10.3 SPARC BGLAP
34 sclerosing liposarcoma 10.3 MDM2 CD34
35 paratesticular lipoma 10.3 MDM2 CDK4
36 lipoma of spermatic cord 10.3 MDM2 CDK4
37 adult liposarcoma 10.3 MDM2 CDK4
38 fibrous histiocytoma 10.3
39 inflammatory liposarcoma 10.3 MDM2 CD34
40 retroperitoneal hemangiopericytoma 10.3 CD68 CD34
41 parameningeal embryonal rhabdomyosarcoma 10.3 MDM2 CDK4
42 hereditary melanoma 10.3 MDM2 CDK4
43 papillary cystadenocarcinoma 10.3 SPARC BGLAP
44 pulmonary artery leiomyosarcoma 10.3 CD68 CD34
45 glomeruloid hemangioma 10.2 CD68 CD34
46 periosteal osteogenic sarcoma 10.2 SATB2 MDM2
47 mandibular cancer 10.2 SP7 MDM2
48 sclerosteosis 1 10.2 SP7 BGLAP
49 malignant giant cell tumor of soft parts 10.2 CD68 CD34
50 heart cancer 10.2 MDM2 CD34

Graphical network of the top 20 diseases related to Extraosseous Osteosarcoma:



Diseases related to Extraosseous Osteosarcoma

Symptoms & Phenotypes for Extraosseous Osteosarcoma

UMLS symptoms related to Extraosseous Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.64 SP7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.64 SPARC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 9.64 SP7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.64 SPARC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-13 9.64 SP7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.64 RPN1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-157 9.64 RPN1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 9.64 RPN1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.64 SPARC
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.64 RPN1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.64 SPARC
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.64 SP7
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-201 9.64 RPN1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.64 SP7
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-215 9.64 RPN1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 9.64 SP7
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.64 RPN1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.64 SP7 SPARC
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.64 SPARC
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.64 RPN1

Drugs & Therapeutics for Extraosseous Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Extraosseous Osteosarcoma

Genetic Tests for Extraosseous Osteosarcoma

Anatomical Context for Extraosseous Osteosarcoma

MalaCards organs/tissues related to Extraosseous Osteosarcoma:

40
Bone, Heart, Kidney, Breast, Skin, Colon, Lung

Publications for Extraosseous Osteosarcoma

Articles related to Extraosseous Osteosarcoma:

(show top 50) (show all 376)
# Title Authors PMID Year
1
Bone Tumors Occurring in the Soft Tissues: A Review of the Clinical, Imaging, and Histopathologic Findings. 61
32665061 2021
2
Extraskeletal osteosarcomas: current update. 61
33533642 2021
3
Primary Exophytic Extraskeletal Osteosarcoma of the Liver: A Case Report and Literature Review. 61
33737841 2021
4
[Primary extraskeletal osteosarcoma: a clinicopathological study of ten cases]. 61
33396986 2021
5
A very rare mass mimicking paraganglioma in the parapharyngeal area: extraskeletal osteosarcoma. 61
33422481 2020
6
Primary Cutaneous Extraskeletal Osteosarcoma of the Temple Treated by Mohs Micrographic Surgery. 61
31397773 2020
7
Primary orbital extraskeletal osteosarcoma and review of literature. 61
33092564 2020
8
The Role of Chemotherapy in Extraskeletal Osteosarcoma: A Propensity Score Analysis of the Surveillance Epidemiology and End Results (SEER) Database. 61
32792473 2020
9
Intraocular extraskeletal osteosarcoma in a rabbit (Oryctolagus cuniculus). 61
32612011 2020
10
Diagnosis of primary osteosarcoma of the urinary bladder in a resource-limited setting: a case report and review of the literature. 61
32728416 2020
11
Intraperitoneal extraosseous osteosarcoma: a case report and literatures review. 61
32653041 2020
12
Cystic extraskeletal osteosarcoma: Three case reports and review of the literature. 61
32257205 2020
13
Extraskeletal osteosarcoma associated with a benign hair follicle tumor in a dog. 61
32355353 2020
14
Anal extraskeletal osteosarcoma in a man: a case report and review of the literature. 61
32312303 2020
15
Extraskeletal osteosarcoma related to inguinal hernia: A rare presentation. 61
31331618 2020
16
Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review. 61
30655112 2020
17
Role of radiation therapy for pediatric upper extremity extraskeletal osteosarcoma: A case series. 61
31710168 2020
18
Primary Osteosarcoma of the Liver: Case Report and Literature Review. 61
30357750 2020
19
Subcutaneous extraskeletal osteosarcoma of foot: A case report. 61
33076190 2020
20
Establishment and characterization of novel patient-derived extraskeletal osteosarcoma cell line NCC-ESOS1-C1. 61
31625124 2020
21
[Biphasic (dedifferentiated) osteosarcoma of the lung in the light of current ideas on biphasic tumors]. 61
32096492 2020
22
Extraskeletal osteosarcoma misdiagnosed as heterotopic ossification after periprosthetic femoral fracture: A case report. 61
32175906 2020
23
The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma. 61
31806415 2020
24
What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. 61
31701222 2020
25
Recurrent, Large, Extraskeletal Osteosarcoma at the Back. 61
31779769 2019
26
[A Case of Extraosteosarcoma in the Omentum]. 61
32157021 2019
27
Surgery and Proton Beam Therapy for Mediastinal Extraskeletal Osteosarcoma. 61
31034825 2019
28
A low grade osteosarcoma of the colon. 61
31701810 2019
29
Prognostic implication of adjuvant/neoadjuvant chemotherapy consisting of doxorubicin and ifosfamide in patients with extraskeletal osteosarcoma. 61
31197555 2019
30
Clinical and Molecular Analysis of Pathologic Fracture-associated Osteosarcoma: MicroRNA profile Is Different and Correlates with Prognosis. 61
31389890 2019
31
Primary Extraskeletal Osteosarcoma in the Anterior Mediastinum: A Case Report and Review. 61
31404412 2019
32
A rare variant of extraskeletal osteosarcoma presenting as a clinically benign subcutaneous neoplasm. 61
30972791 2019
33
An extraskeletal osteosarcoma in the auricle of a Wistar Hannover rat. 61
31404367 2019
34
Outcomes of surgery and/or combination chemotherapy for extraskeletal osteosarcoma: a single-center retrospective study from China. 61
30886189 2019
35
Extraskeletal Osteosarcomas: A Case Made for Combined Modality Local Therapy With Radiation and Surgery. 61
30614820 2019
36
Extraskeletal Osteosarcoma: A Rare Case Arising in Phthisis Bulbi with a Review of the Literature. 61
30976589 2019
37
Extraskeletal Osteosarcoma Recognized following Acute Traumatic Injury. 61
31097937 2019
38
Primary extraskeletal osteosarcoma of the mesentery: A case report. 61
31212092 2019
39
Fibro-osseous pseudotumor on the hyponychium of the great toe. 61
30710901 2019
40
18F-FDG PET/CT in Isolated Primary Extraskeletal Osteosarcoma. 61
30273208 2018
41
Subclassification of pleomorphic sarcomas: How and why should we care? 61
30340082 2018
42
Extraskeletal osteosarcoma arising in the subcutaneous tissue of the lower leg: A case report and literature review. 61
30112173 2018
43
A case of primary extraskeletal osteosarcoma of the breast. 61
30232644 2018
44
Extraskeletal Osteosarcoma: Outcomes and the Role of Chemotherapy. 61
28622153 2018
45
Primary Extraskeletal Osteosarcoma Arising from the Optic Nerve: A Rare Case Report. 61
30320102 2018
46
Clinical, radiological, and pathological features of extraskeletal osteosarcoma. 61
29502131 2018
47
Extraskeletal osteosarcoma in right neck subcutaneous tissue: A case report of an extremely rare tumour. 61
30101012 2018
48
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity. 61
29489027 2018
49
Extraskeletal osteosarcoma in the parotid gland: A case report. 61
28947094 2018
50
Pancreatic Extraskeletal Osteosarcoma Metastasizing to the Scalp. 61
29853753 2018

Variations for Extraosseous Osteosarcoma

Expression for Extraosseous Osteosarcoma

Search GEO for disease gene expression data for Extraosseous Osteosarcoma.

Pathways for Extraosseous Osteosarcoma

Pathways related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 SPARC SP7 CD34 BGLAP
2 10.46 MDM2 CDK4

GO Terms for Extraosseous Osteosarcoma

Biological processes related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to organic substance GO:0071310 9.32 SATB2 MDM2
2 negative regulation of cell cycle arrest GO:0071157 9.26 MDM2 CDK4
3 response to lead ion GO:0010288 9.16 SPARC CDK4
4 osteoblast development GO:0002076 8.96 SATB2 BGLAP
5 response to gravity GO:0009629 8.62 SPARC BGLAP

Sources for Extraosseous Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....