MCID: EXT032
MIFTS: 39

Extraosseous Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Extraosseous Osteosarcoma

MalaCards integrated aliases for Extraosseous Osteosarcoma:

Name: Extraosseous Osteosarcoma 12 15
Extraskeletal Osteosarcoma 12 73
Extraskeletal Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3357
NCIt 50 C8810
SNOMED-CT 68 404077005
UMLS 73 C0855052

Summaries for Extraosseous Osteosarcoma

MalaCards based summary : Extraosseous Osteosarcoma, also known as extraskeletal osteosarcoma, is related to adult extraosseous osteosarcoma and childhood extraosseous osteosarcoma, and has symptoms including pain An important gene associated with Extraosseous Osteosarcoma is GALNT3 (Polypeptide N-Acetylgalactosaminyltransferase 3), and among its related pathways/superpathways are B Cell Development Pathways and Integrated Cancer Pathway. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Extraosseous Osteosarcoma

Diseases in the Extraosseous Osteosarcoma family:

Adult Extraosseous Osteosarcoma

Diseases related to Extraosseous Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 adult extraosseous osteosarcoma 12.4
2 childhood extraosseous osteosarcoma 12.1
3 ring chromosome 7 10.5 CDK4 MDM2
4 spindle cell sarcoma 10.5 KRT7 MDM2
5 undifferentiated embryonal sarcoma of the liver 10.5 CDK4 MDM2
6 infiltrating angiolipoma 10.5 CDK4 MDM2
7 spindle cell lipoma 10.5 CDK4 MDM2
8 inflammatory mfh 10.5 CDK4 MDM2
9 bone osteosarcoma 10.5 CDK4 MDM2
10 lipoblastoma 10.5 CDK4 MDM2
11 malignant fibrous histiocytoma of bone 10.5 CDK4 MDM2
12 periosteal chondrosarcoma 10.4 CDK4 MDM2
13 atypical lipomatous tumor 10.4 CDK4 MDM2
14 dedifferentiated liposarcoma 10.4 CDK4 MDM2
15 breast secretory carcinoma 10.4 CDK4 KRT7
16 small cell sarcoma 10.4 CDK4 MDM2
17 retroperitoneal fibrosis 10.4 MDM2 PTPRC
18 juxtacortical osteosarcoma 10.4 CDK4 MDM2
19 sclerosing liposarcoma 10.4 CD34 MDM2
20 mucinous cystadenocarcinoma 10.4 KRT7 PTPRC
21 embryonal sarcoma 10.4 CDK4 MDM2
22 immune system organ benign neoplasm 10.4 KRT7 PTPRC
23 thymus lipoma 10.4 KRT7 PTPRC
24 type 1 diabetes mellitus 7 10.4 GALNT3 HBA1
25 adenoid squamous cell carcinoma 10.3 HBA1 KRT7
26 lipomatosis, multiple 10.3 CDK4 MDM2
27 intraneural perineurioma 10.3 CD34 KRT7
28 extracutaneous mastocytoma 10.3 CD34 PTPRC
29 peripheral osteosarcoma 10.3 CDK4 MDM2
30 spindle cell synovial sarcoma 10.3 CD34 KRT7
31 liver inflammatory pseudotumor 10.3 CD34 PTPRC
32 diffuse cutaneous mastocytosis 10.3 CD34 PTPRC
33 sarcomatoid squamous cell skin carcinoma 10.3 CD34 PTPRC
34 fibrosarcoma of bone 10.3 CDK4 MDM2
35 chronic monocytic leukemia 10.3 CD34 PTPRC
36 skin sarcoma 10.2 CD34 CDK4
37 retinal cancer 10.2 CDK4 MDM2
38 sensory system cancer 10.2 CDK4 MDM2
39 ovary sarcoma 10.2 CD34 HBA1
40 ovarian angiosarcoma 10.2 CD34 HBA1
41 intravascular fasciitis 10.2 CD34 HBA1
42 pediatric angiosarcoma 10.2 CD34 HBA1
43 thyroid angiosarcoma 10.2 CD34 HBA1
44 reticulohistiocytic granuloma 10.2 CD34 PTPRC
45 neurogenic arthropathy 10.2 CD34 HBA1
46 hemangiopericytoma, malignant 10.2 HBA1 MDM2
47 thyroid sarcoma 10.2 CD34 HBA1
48 hobnail hemangioma 10.2 CD34 HBA1
49 cellular schwannoma 10.2 CD34 MDM2
50 hemangioma of liver 10.2 CD34 HBA1

Graphical network of the top 20 diseases related to Extraosseous Osteosarcoma:



Diseases related to Extraosseous Osteosarcoma

Symptoms & Phenotypes for Extraosseous Osteosarcoma

UMLS symptoms related to Extraosseous Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD34 CDK4 GALNT3 KRT7 MDM2 PTPRC

MGI Mouse Phenotypes related to Extraosseous Osteosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CD34 CDK4 GALNT3 KRT7 MDM2 PTPRC
2 homeostasis/metabolism MP:0005376 9.7 CD34 CDK4 GALNT3 KRT7 MDM2 PTPRC
3 neoplasm MP:0002006 9.35 CD34 CDK4 MDM2 PTPRC SMUG1
4 renal/urinary system MP:0005367 9.02 MDM2 PTPRC CDK4 GALNT3 KRT7

Drugs & Therapeutics for Extraosseous Osteosarcoma

Drugs for Extraosseous Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
7
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
8 Alkylating Agents Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
10 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
11 Antineoplastic Agents, Alkylating Phase 3,Phase 2
12
Isophosphamide mustard Phase 3,Phase 2 0
13 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Phytogenic Phase 3
15 Etoposide phosphate Phase 3
16
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
17
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
18
Gemcitabine Approved Phase 2 95058-81-4 60750
19 Angiogenesis Inhibitors Phase 2
20 Angiogenesis Modulating Agents Phase 2
21 Immunosuppressive Agents Phase 2
22 Anti-Infective Agents Phase 2
23 Antimetabolites Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Antiviral Agents Phase 2
26 Antibodies Phase 1
27 Antibodies, Monoclonal Phase 1
28 Immunoglobulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
4 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
5 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
6 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
7 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
8 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
9 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
10 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride

Search NIH Clinical Center for Extraosseous Osteosarcoma

Genetic Tests for Extraosseous Osteosarcoma

Anatomical Context for Extraosseous Osteosarcoma

MalaCards organs/tissues related to Extraosseous Osteosarcoma:

41
Bone, Lung, Liver, Breast, Colon, Small Intestine

Publications for Extraosseous Osteosarcoma

Articles related to Extraosseous Osteosarcoma:

(show top 50) (show all 60)
# Title Authors Year
1
A Rare Extraskeletal Osteosarcoma Appearing After 55 Years on a Large Stage 3 Burn Scar. ( 29971170 )
2018
2
Extraskeletal osteosarcoma arising in myositis ossificans: a case report and review of the literature. ( 28536749 )
2017
3
Anterior abdominal wall extraosseous osteosarcoma, occurring 40 years after para-aortic irradiation. ( 28645924 )
2017
4
Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. ( 28235629 )
2017
5
Treatment of extraskeletal osteosarcoma at a previous injection site resulting in prolonged survival in 1 dog. ( 27587886 )
2016
6
Osteoblastic Extraosseous Osteosarcoma of the Neck. ( 27914228 )
2016
7
Extraosseous Osteosarcoma of the Liver Demonstrated on 18F-FDG PET/CT Imaging. ( 27055145 )
2016
8
Large Retroperitoneal Extraosseous Osteosarcoma Invading into the Spine: a Case Report. ( 27872537 )
2016
9
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas? ( 26197952 )
2015
10
CORR Insights(Ar): Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas? ( 26310679 )
2015
11
Analysis of Outcomes in Extraskeletal Osteosarcoma: A Review of Fifty-three Cases. ( 24382730 )
2014
12
SPECT/CT Imaging of Retroperitoneal Extraskeletal Osteosarcoma. ( 24300353 )
2014
13
Small cell extraskeletal osteosarcoma: a rare case report. ( 24711902 )
2014
14
Extraskeletal Osteosarcoma: An International Rare Cancer Network Study. ( 24401667 )
2014
15
Extraskeletal osteosarcoma of the pancreatic head. ( 23896237 )
2013
16
Spontaneous Extraskeletal Osteosarcoma in a Rabbit (Oryctolagus cuniculus): Histopathological and Immunohistochemical Findings. ( 24155564 )
2013
17
Osteosarcoma of breast: a rare case of extraskeletal osteosarcoma. ( 23771379 )
2013
18
Extraosseous osteosarcoma arising in recurrent ossifying fibromyxoid tumor of soft tissue: a case report. ( 23805469 )
2013
19
18F-FDG PET/CT in a rare malignant extraskeletal osteosarcoma. ( 23856822 )
2013
20
Canine spirocercosis-associated extraskeletal osteosarcoma with central nervous system metastasis. ( 23718148 )
2013
21
Extraskeletal Osteosarcoma: A case report and review of the literature. ( 24421944 )
2013
22
Extraskeletal osteosarcoma of the orbit: A clinicopathologic case report and review of literature. ( 23552350 )
2013
23
Extraosseous osteosarcoma: a case report and review of the literature. ( 23691705 )
2013
24
Extraskeletal osteosarcoma: a very rare case report of primary tumor of the colon-rectum and review of the literature. ( 23642451 )
2013
25
An abdominal extraskeletal osteosarcoma: A case report. ( 24137451 )
2013
26
Extraskeletal osteosarcoma of the hand. ( 23450980 )
2012
27
Extraosseous osteosarcoma in the neck. ( 21873010 )
2012
28
A large calcified retroperitoneal extraskeletal osteosarcoma with consequent bilateral hydronephrosis. ( 22953650 )
2012
29
Primary extraskeletal osteosarcoma of omentum majus. ( 21333013 )
2011
30
Extraskeletal osteosarcoma of the thorax in a goat: case report. ( 21929794 )
2011
31
Primary extraosseous osteosarcoma of the lung. ( 19452304 )
2010
32
Extraosseous osteosarcoma: single institutional experience in Korea. ( 20565425 )
2010
33
Well-differentiated extraskeletal osteosarcoma arising from the retroperitoneum that recurred as anaplastic spindle cell sarcoma. ( 20224645 )
2010
34
Extraosseous osteosarcoma of the esophagus: a case report. ( 20224681 )
2010
35
Small cell extraskeletal osteosarcoma. ( 19309043 )
2009
36
Extraosseous osteosarcoma in Ibadan: case series over a 20-year period. ( 21139897 )
2009
37
Combined replacement of infrarenal aorta and inferior vena cava after en bloc resection of retroperitoneal extraosseous osteosarcoma. ( 18644493 )
2008
38
Extraosseous osteosarcoma arising from the small intestinal mesentery. ( 17537587 )
2007
39
What is your diagnosis? Osteochondroma, extraskeletal osteosarcoma, or tumor calcinosis. ( 17571979 )
2007
40
Extraosseous osteosarcoma in a maned wolf (Chrysocyon brachyurus). ( 17312777 )
2005
41
Primary cutaneous extraskeletal osteosarcoma under a previous electrodessicated actinic keratosis. ( 15577761 )
2004
42
[Extraskeletal osteosarcoma in the gallbladder]. ( 12848101 )
2003
43
A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature. ( 12544778 )
2003
44
Extraosseous osteosarcoma: response to treatment and long-term outcome. ( 11786582 )
2002
45
Extraskeletal osteosarcoma arising in myositis ossificans. ( 11289633 )
2001
46
Extraosseous osteosarcoma of the penis. ( 11005691 )
2000
47
Retroperitoneal extraosseous osteosarcoma. A case report and review of literature. ( 10921223 )
1999
48
Extraskeletal osteosarcoma of the mediastinum after treatment of a mediastinal germ-cell tumor. ( 10597747 )
1999
49
Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. ( 9923924 )
1999
50
Extraskeletal osteosarcomas: a clinicopathologic study of 25 cases. ( 9591729 )
1998

Variations for Extraosseous Osteosarcoma

Expression for Extraosseous Osteosarcoma

Search GEO for disease gene expression data for Extraosseous Osteosarcoma.

Pathways for Extraosseous Osteosarcoma

Pathways related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.98 CD34 PTPRC
2 10.82 CDK4 MDM2
3 10.6 CDK4 MDM2
4 10.13 CDK4 MDM2

GO Terms for Extraosseous Osteosarcoma

Biological processes related to Extraosseous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 8.96 CDK4 MDM2
2 negative regulation of cell cycle arrest GO:0071157 8.62 CDK4 MDM2

Sources for Extraosseous Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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