EPTB
MCID: EXT033
MIFTS: 49

Extrapulmonary Tuberculosis (EPTB)

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Extrapulmonary Tuberculosis

MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 12 55 15
Tuberculosis, Extrapulmonary 73
Eptb 48

Classifications:



External Ids:

Disease Ontology 12 DOID:0050598
UMLS 73 C0679362

Summaries for Extrapulmonary Tuberculosis

Disease Ontology : 12 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary : Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to tuberculous peritonitis and miliary tuberculosis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Isoniazid and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Extrapulmonary tuberculosis is tuberculosis (TB) within another location in the body than the lungs.... more...

Related Diseases for Extrapulmonary Tuberculosis

Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 32.2 ADA IFNG TBP
2 miliary tuberculosis 32.1 ADA IFNG
3 abdominal tuberculosis 32.0 ADA TBP
4 pericardial tuberculosis 31.8 ADA IFNG IL10 TBP
5 pleural tuberculosis 31.8 ADA CCL2 IFNG TBP
6 brucellosis 30.4 IFNG IL10 SLC11A1
7 viral infectious disease 30.3 IFNG IL10 IL1B
8 uveitis 30.3 CCL2 IFNG IL10
9 acquired immunodeficiency syndrome 30.2 IFNG IL10 IL1B
10 osteomyelitis 30.0 IFNG IL10 IL1B
11 tuberculous meningitis 30.0 ADA CCL2 TLR2
12 arthritis 29.9 CCL2 IFNG IL10 IL1B
13 human immunodeficiency virus type 1 29.8 ADA CCL2 IFNG IL10
14 otitis media 29.8 IL10 IL1B MBL2 TLR2
15 crohn's disease 29.6 IL10 IL10RA SLC11A1
16 mycobacterium tuberculosis 1 29.6 ADA IFNG IL10 MBL2 P2RX7 SLC11A1
17 systemic lupus erythematosus 29.4 CCL2 IFNG IL10 IL1B MBL2 TLR2
18 pulmonary tuberculosis 29.4 ADA IFNG IL10 MBL2 P2RX7 SLC11A1
19 meningitis 29.3 ADA CCL2 IFNG IL10 IL1B MBL2
20 central nervous system tuberculosis 11.2
21 skeletal tuberculosis 11.2
22 urogenital tuberculosis 11.2
23 lymph node tuberculosis 11.2
24 cephalosporin allergy 10.3 IFNG IL10
25 hyperlucent lung 10.3 IFNG IL10
26 sporotrichosis 10.2 IFNG IL10
27 nickel allergic contact dermatitis 10.2 IFNG IL10
28 staphylococcal toxic shock syndrome 10.2 IFNG IL1B
29 baylisascariasis 10.2 IFNG IL10
30 penicillin allergy 10.2 IFNG IL10
31 palladium allergic contact dermatitis 10.2 CCL2 IL10
32 neurosyphilis 10.2 IL10 TLR2
33 periodontitis, chronic 10.2 IL1B TLR2
34 lymphoma 10.2
35 chronic graft versus host disease 10.2 IFNG IL10
36 coccidioidomycosis 10.2 IL10 MBL2
37 purulent labyrinthitis 10.2 CCL2 IL1B
38 clonorchiasis 10.2 IFNG IL10
39 scleritis 10.2 CCL2 IFNG
40 retinitis pigmentosa 73 10.2 CCL2 IL1B
41 funisitis 10.2 IL10 IL1B
42 tuberculoid leprosy 10.2 IFNG IL10
43 mycoplasma pneumoniae pneumonia 10.2 IFNG IL10 TLR2
44 fascioliasis 10.2 IFNG IL10 IL1B
45 eales disease 10.2 IFNG IL10 IL1B
46 paracoccidioidomycosis 10.2 IFNG IL10 TLR2
47 opportunistic mycosis 10.2 IFNG IL10 TLR2
48 ascaris lumbricoides infection 10.2 IFNG IL1B
49 aseptic meningitis 10.2 IFNG IL10 IL1B
50 echinococcosis 10.2 IFNG IL10 TLR2

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis

Symptoms & Phenotypes for Extrapulmonary Tuberculosis

MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 ADA IFNG IL10 IL1B P2RX7 TBP
2 hematopoietic system MP:0005397 10.06 ADA IFNG IL10 IL10RA IL1B MBL2
3 growth/size/body region MP:0005378 10.02 ADA IFNG IL10 IL1B P2RX7 PCDH15
4 homeostasis/metabolism MP:0005376 10 ADA IFNG IL10 IL10RA IL1B MBL2
5 digestive/alimentary MP:0005381 9.95 ADA IFNG IL10 IL10RA SLC11A1 TLR2
6 immune system MP:0005387 9.93 ADA CCL2 IFNG IL10 IL10RA IL1B
7 muscle MP:0005369 9.43 ADA IFNG IL10 PCDH15 TLR2 VDR
8 skeleton MP:0005390 9.23 ADA IFNG IL10 IL1B P2RX7 TBP

Drugs & Therapeutics for Extrapulmonary Tuberculosis

Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
3
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
4 Cytochrome P-450 CYP3A Inducers Phase 3
5 Anti-Infective Agents Phase 3,Not Applicable
6 Lipid Regulating Agents Phase 3
7 Antitubercular Agents Phase 3
8 Anti-Bacterial Agents Phase 3
9 Antimetabolites Phase 3,Not Applicable
10 Antibiotics, Antitubercular Phase 3
11 Hypolipidemic Agents Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13
Lithium carbonate Approved 554-13-2
14
Heparin Approved, Investigational 9005-49-6 772 46507594
15 Deoxyglucose Not Applicable
16 Fluorodeoxyglucose F18 Not Applicable
17 Antiviral Agents Not Applicable
18 calcium heparin

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Tuberculosis Prevention for HIV Infected Adults Completed NCT00057122 Phase 3 Isoniazid;Rifapentine;Rifampin
2 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
3 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
4 PET/CT in Extrapulmonary TB in HIV Patients: a Clinical Trial Completed NCT02822014 Not Applicable
5 Intervention in the Management of Post-high Tuberculosis Hospital Through Educational Strategy and Oversight Distance Completed NCT02558842 Not Applicable
6 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
7 Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Recruiting NCT03271567
8 Paradoxical Reactions in Non Immuno-compromized Patients With Extrapulmonary Tuberculosis Active, not recruiting NCT01252992
9 Effect of Xpert MTB/RIF on Patient Outcomes Active, not recruiting NCT02729532
10 Role of Genexpert in Extra Pulmonary Tuberculosis Not yet recruiting NCT03173261 Not Applicable
11 Bronchial Washings in Sputum Scarce Cases of Pulmonary Tuberculosis Not yet recruiting NCT03732014
12 A Study on the Safety and Effectiveness of Rilpivirine Hydrochloride (Edurant) Among Adult Filipino Patients With Human Immunodeficiency Virus Type-I Infection Withdrawn NCT01692470 No intervention

Search NIH Clinical Center for Extrapulmonary Tuberculosis

Genetic Tests for Extrapulmonary Tuberculosis

Anatomical Context for Extrapulmonary Tuberculosis

MalaCards organs/tissues related to Extrapulmonary Tuberculosis:

41
Lung, Bone, Testes, T Cells, Kidney, Lymph Node, B Cells

Publications for Extrapulmonary Tuberculosis

Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 429)
# Title Authors Year
1
Fever with pancytopenia: unusual presentation of extrapulmonary tuberculosis: a case report. ( 29506574 )
2018
2
The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis. ( 29950533 )
2018
3
The Use of TB-Specific Antigen/Phytohemagglutinin Ratio for Diagnosis and Treatment Monitoring of Extrapulmonary Tuberculosis. ( 29868010 )
2018
4
Prevalence and risk factors of drug-resistant extrapulmonary tuberculosis. ( 29424965 )
2018
5
Performance of the IS6110-TaqManAr assay in the diagnosis of extrapulmonary tuberculosis from different biological samples. ( 29972564 )
2018
6
Diagnostic accuracy of the loop-mediated isothermal amplification assay for extrapulmonary tuberculosis: A meta-analysis. ( 29944682 )
2018
7
MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. ( 29742144 )
2018
8
Positive outcome of pulmonary tuberculosis associated with extraordinary extensive extrapulmonary tuberculosis in an immunocompetent adult. ( 29900898 )
2018
9
Response to the review article "Imaging in extrapulmonary tuberculosis" from the International Atomic Energy Agency Extra-pulmonary TB Consortium; March 2017, volume 56, pages 237-247. ( 29155088 )
2018
10
A Hospital-Based Cross-sectional Study on Clinico-demographic Characteristic of Extrapulmonary Tuberculosis Cases Coming to a Tertiary Hospital of Bihar. ( 29899614 )
2018
11
Eosinophilia, a marker of asymptomatic<i>Strongyloides</i>infection, in a young patient with extrapulmonary tuberculosis. ( 29301814 )
2018
12
Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients. ( 29141727 )
2018
13
Evaluation of the Xpert MTB/RIF assay for diagnosis of smear-negative pulmonary and extrapulmonary tuberculosis in Madagascar. ( 29408360 )
2018
14
Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis. ( 29872046 )
2018
15
Specific cholecystitis: An unusual presentation of extrapulmonary tuberculosis. ( 30243911 )
2018
16
A Review of Extrapulmonary Tuberculosis. ( 29991098 )
2018
17
Prospective Serial FDG PET/CT During Treatment of Extrapulmonary Tuberculosis in HIV-Infected Patients: An Exploratory Study. ( 30015658 )
2018
18
Patterns of uveitis in patients with proven systemic (pulmonary and extrapulmonary) tuberculosis. ( 30022332 )
2018
19
Extrapulmonary Tuberculosis in Federation of Bosnia and Herzegovina. ( 30061808 )
2018
20
Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance. ( 30148542 )
2018
21
Delayed diagnosis of extrapulmonary tuberculosis presenting as fever of unknown origin in an intermediate-burden country. ( 30153813 )
2018
22
Extrapulmonary tuberculosis: atypical presentation in otorhinolaryngology. ( 30158260 )
2018
23
Assessment of Extrapulmonary Tuberculosis Using Gene Xpert MTB/RIF Assay and Fluorescent Microscopy and Its Risk Factors at Dessie Referral Hospital, Northeast Ethiopia. ( 30159328 )
2018
24
Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: A study from Zanzibar. ( 30188947 )
2018
25
Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India. ( 30197919 )
2018
26
Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis. ( 30200884 )
2018
27
Tuberculosis of the elbow: A rare form of presentation of extrapulmonary tuberculosis. ( 30241670 )
2018
28
Diagnostic accuracy of Xpert MTB/RIF assay in extrapulmonary tuberculosis. ( 30429387 )
2018
29
Prevalence of extrapulmonary tuberculosis among people living with HIV/AIDS in sub-Saharan Africa: a systemic review and meta-analysis. ( 30464643 )
2018
30
Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran. ( 30513341 )
2018
31
Index-TB guidelines: Guidelines on extrapulmonary tuberculosis for India. ( 28862176 )
2017
32
Extrapulmonary Tuberculosis of Lymph Node Coexist with Diffuse Large B-cell Lymphoma: A Case Report. ( 29200700 )
2017
33
Detection of ofloxacin resistance by nitrate reductase assay in Mycobacterium tuberculosis isolates from extrapulmonary tuberculosis. ( 28303821 )
2017
34
Immune Reconstitution Inflammatory Syndrome Occurring in a Kidney Transplant Patient with Extrapulmonary Tuberculosis. ( 28367350 )
2017
35
Use of Digital Droplet PCR to Detect Mycobacterium tuberculosis DNA in Whole Blood-Derived DNA Samples from Patients with Pulmonary and Extrapulmonary Tuberculosis. ( 28848722 )
2017
36
Treatment outcome of extrapulmonary tuberculosis under Revised National Tuberculosis Control Programme. ( 28410692 )
2017
37
Identification of Mycobacterium tuberculosis in Clinical Specimens of Patients Suspected of Having Extrapulmonary Tuberculosis by Application of Nested PCR on Five Different Genes. ( 28144587 )
2017
38
Fundus findings in a series of patients with extrapulmonary tuberculosis in Thailand. ( 28450377 )
2017
39
Extrapulmonary tuberculosis in colombian children: Epidemiological and clinical data in a reference hospital. ( 28559513 )
2017
40
Absorption, distribution, and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis. ( 28092695 )
2017
41
Secretion of IFN-I^ Associated with Galectin-9 Production by Pleural Fluid Cells from a Patient with Extrapulmonary Tuberculosis. ( 28657598 )
2017
42
Recovery of Mycobacterium lentiflavum from bronchial lavage during follow-up of an extrapulmonary tuberculosis patient. ( 28776534 )
2017
43
Enigma of Extrapulmonary Tuberculosis: Where Do We Stand? ( 29021926 )
2017
44
Comparative Diagnostic Utility of Neopterin and IFN-I^/IL-2 in Extrapulmonary Tuberculosis. ( 29062177 )
2017
45
Association of Single-Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis. ( 28530443 )
2017
46
Rapid diagnosis of extrapulmonary tuberculosis with Xpert Mycobacterium tuberculosis/rifampicin assay. ( 28708053 )
2017
47
Two cases of tuberculous spondylodiscitis: a rare manifestation of extrapulmonary tuberculosis. ( 28275564 )
2017
48
Delays in diagnosis and treatment of extrapulmonary tuberculosis in Guatemala. ( 28993352 )
2017
49
Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis. ( 29424197 )
2017
50
Concurrent evaluation of microscopic observation of drug susceptibility assay for pulmonary and extrapulmonary tuberculosis. ( 28367022 )
2017

Variations for Extrapulmonary Tuberculosis

Expression for Extrapulmonary Tuberculosis

Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.

Pathways for Extrapulmonary Tuberculosis

Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CCL2 IFNG IL10 IL10RA IL1B MBL2
2
Show member pathways
13.29 CCL2 IL10 IL10RA IL1B TIRAP TLR2
3
Show member pathways
12.93 CCL2 IL10RA IL1B TIRAP TLR2
4
Show member pathways
12.69 CCL2 IFNG IL1B TBP TLR2
5
Show member pathways
12.61 CCL2 IFNG IL10 IL1B MBL2 P2RX7
6
Show member pathways
12.47 IFNG IL10 IL1B TLR2
7
Show member pathways
12.47 CCL2 IFNG IL10 IL10RA IL1B
8 12.42 CCL2 IFNG IL10 IL1B TLR2
9
Show member pathways
12.24 CCL2 IFNG IL1B TLR2
10
Show member pathways
12.09 IFNG IL1B TIRAP TLR2
11
Show member pathways
12.07 IFNG IL10 IL10RA IL1B TLR2
12 11.98 CCL2 IFNG IL1B
13
Show member pathways
11.98 CCL2 IFNG IL10 IL10RA IL1B
14
Show member pathways
11.94 IFNG IL1B TLR2
15
Show member pathways
11.94 IFNG IL10 IL1B TLR2
16 11.9 CCL2 IFNG IL1B
17 11.87 CCL2 IL10 IL1B
18 11.78 IFNG IL10 IL10RA
19 11.76 IFNG IL10 IL1B TLR2
20 11.71 IFNG IL10 IL1B
21 11.71 CCL2 IFNG IL1B TLR2
22 11.68 IL10 IL1B TIRAP
23 11.66 IFNG IL10 IL1B
24 11.59 CCL2 IFNG IL10 IL1B
25 11.42 IFNG IL10 IL10RA IL1B TIRAP TLR2
26 11.41 IFNG IL1B VDR
27 11.36 CCL2 IL10 IL10RA IL1B
28 11.3 CCL2 IFNG IL1B TLR2
29 11.28 IFNG IL10 IL1B
30 11.27 IL10 IL10RA IL1B
31 11.13 IFNG IL10 IL1B
32 11.12 CCL2 IL10 IL1B TBP
33 11.04 CCL2 IFNG IL10 IL1B TLR2
34 10.96 CCL2 IFNG IL1B TLR2
35 10.85 CCL2 IL1B

GO Terms for Extrapulmonary Tuberculosis

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.96 CCL2 IFNG IL10 IL1B
2 negative regulation of cell proliferation GO:0008285 9.94 IL10 IL1B TLR2 VDR
3 response to drug GO:0042493 9.9 ADA IL10 IL1B P2RX7
4 cytokine-mediated signaling pathway GO:0019221 9.88 CCL2 IL10 IL10RA IL1B
5 cell surface receptor signaling pathway GO:0007166 9.87 CCL2 IFNG P2RX7 TIRAP
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B TIRAP TLR2
7 immune response GO:0006955 9.8 CCL2 IFNG IL10 IL1B SLC11A1 TLR2
8 response to bacterium GO:0009617 9.79 CCL2 P2RX7 SLC11A1
9 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 IL1B P2RX7
10 positive regulation of interleukin-6 production GO:0032755 9.7 IL1B P2RX7 TLR2
11 defense response to Gram-positive bacterium GO:0050830 9.67 MBL2 P2RX7 TIRAP TLR2
12 positive regulation of neutrophil chemotaxis GO:0090023 9.65 IL1B TIRAP
13 positive regulation of T cell activation GO:0050870 9.65 ADA CCL2
14 positive regulation of phagocytosis GO:0050766 9.65 IL1B MBL2 SLC11A1
15 defense response to protozoan GO:0042832 9.63 IL10 SLC11A1
16 response to ATP GO:0033198 9.63 IL1B P2RX7
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL2 IL1B TLR2
18 positive regulation of gene expression GO:0010628 9.63 IFNG IL1B P2RX7 SLC11A1 TLR2 VDR
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG IL1B
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 IL1B
21 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 CCL2 TLR2
22 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B TIRAP TLR2
23 response to molecule of bacterial origin GO:0002237 9.59 IL10 TLR2
24 cellular response to lipoteichoic acid GO:0071223 9.58 TIRAP TLR2
25 positive regulation of interleukin-12 production GO:0032735 9.58 IFNG TIRAP TLR2
26 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.55 IL1B TIRAP
27 positive regulation of prostaglandin secretion GO:0032308 9.54 IL1B P2RX7
28 cellular response to bacterial lipopeptide GO:0071221 9.51 TIRAP TLR2
29 inflammatory response GO:0006954 9.5 CCL2 IL10 IL1B P2RX7 SLC11A1 TIRAP
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG IL1B
31 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 MBL2 TIRAP
32 response to lipopolysaccharide GO:0032496 9.17 IL10 IL10RA IL1B P2RX7 SLC11A1 TIRAP

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 IL10RA P2RX7 TLR2 VDR
2 cytokine activity GO:0005125 8.92 CCL2 IFNG IL10 IL1B

Sources for Extrapulmonary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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