MCID: EXT033
MIFTS: 46

Extrapulmonary Tuberculosis

Categories: Infectious diseases

Aliases & Classifications for Extrapulmonary Tuberculosis

MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 12 55 15
Tuberculosis, Extrapulmonary 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050598
UMLS 73 C0679362

Summaries for Extrapulmonary Tuberculosis

Disease Ontology : 12 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary : Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to abdominal tuberculosis and tuberculous peritonitis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Influenza A. The drugs Isoniazid and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Extrapulmonary tuberculosis is tuberculosis (TB) within another location in the body than the lungs.... more...

Related Diseases for Extrapulmonary Tuberculosis

Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 abdominal tuberculosis 32.3 ADA TBP
2 tuberculous peritonitis 32.3 ADA IFNG TBP
3 pericardial tuberculosis 31.6 ADA IFNG IL10 TBP
4 pleural tuberculosis 31.5 ADA CCL2 IFNG TBP
5 acquired immunodeficiency syndrome 30.6 IFNG IL10 IL1B
6 uveitis 30.3 CCL2 IFNG IL10
7 tuberculous meningitis 30.2 ADA CCL2 TLR2
8 crohn's disease 30.0 IL10 IL1B SLC11A1
9 osteomyelitis 29.7 IFNG IL1B IL1RN
10 brucellosis 29.6 IFNG IL10 IL1RN SLC11A1
11 otitis media 29.5 IL10 IL1B MBL2 TLR2
12 arthritis 28.8 CCL2 IFNG IL10 IL1B IL1RN
13 pulmonary tuberculosis 28.4 ADA IFNG IL10 MBL2 P2RX7 SLC11A1
14 meningitis 28.3 ADA CCL2 IFNG IL10 IL1B MBL2
15 central nervous system tuberculosis 11.1
16 skeletal tuberculosis 11.1
17 urogenital tuberculosis 11.1
18 lymph node tuberculosis 11.1
19 miliary tuberculosis 11.1
20 hyperlucent lung 10.8 IFNG IL10
21 staphylococcal toxic shock syndrome 10.8 IFNG IL1B
22 autoimmune myocarditis 10.8 IFNG IL1B
23 sporotrichosis 10.8 IFNG IL10
24 baylisascariasis 10.7 IFNG IL10
25 purulent labyrinthitis 10.7 CCL2 IL1B
26 periodontitis, chronic 10.7 IL1B TLR2
27 neurosyphilis 10.6 IL10 TLR2
28 chronic graft versus host disease 10.6 IFNG IL10
29 funisitis 10.6 IL10 IL1B
30 retinitis pigmentosa 73 10.6 CCL2 IL1B
31 fascioliasis 10.6 IFNG IL10 IL1B
32 eales disease 10.6 IFNG IL10 IL1B
33 tuberculoid leprosy 10.6 IFNG IL10
34 erdheim-chester disease 10.5 CCL2 IL1B
35 clonorchiasis 10.5 IFNG IL10
36 scabies 10.5 IL10 MBL2
37 primary systemic mycosis 10.5 IFNG IL10 TLR2
38 viral meningitis 10.5 ADA CCL2 IFNG
39 anterior uveitis 10.5 CCL2 TLR2
40 allergic contact dermatitis 10.5 IFNG IL10 IL1B
41 gastroenteritis 10.5 IFNG IL10 IL1B
42 contact dermatitis 10.5 IFNG IL10 IL1B
43 pleurisy 10.5 ADA CCL2 IFNG
44 lepromatous leprosy 10.5 IFNG IL10 TLR2
45 toxoplasmosis 10.5 IFNG IL10 IL1B
46 intestinal disease 10.5 IFNG IL10 IL1B
47 hypersensitivity reaction disease 10.5 IFNG IL10 IL1B
48 mouth disease 10.5 IFNG IL10 IL1B
49 paracoccidioidomycosis 10.5 IFNG IL10 TLR2
50 graft-versus-host disease 10.5 IFNG IL10 IL1B

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis

Symptoms & Phenotypes for Extrapulmonary Tuberculosis

MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 IL10 TIRAP IL1B TLR2 IL1RN ADA
2 growth/size/body region MP:0005378 9.97 TBP IL10 IL1B IL1RN ADA P2RX7
3 hematopoietic system MP:0005397 9.96 TIRAP IL1B TLR2 IL1RN ADA MBL2
4 homeostasis/metabolism MP:0005376 9.85 TBP IL10 TIRAP IL1B TLR2 IL1RN
5 immune system MP:0005387 9.7 TIRAP IL1B TLR2 IL1RN ADA MBL2
6 skeleton MP:0005390 9.23 TBP IL10 IL1B TLR2 IL1RN ADA

Drugs & Therapeutics for Extrapulmonary Tuberculosis

Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
3
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Anti-Infective Agents Phase 3,Not Applicable
7 Antimetabolites Phase 3,Not Applicable
8 Antitubercular Agents Phase 3
9 Cytochrome P-450 CYP3A Inducers Phase 3
10 Hypolipidemic Agents Phase 3
11 Lipid Regulating Agents Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13
Heparin Approved, Investigational 9005-49-6 772 46507594
14 Antiviral Agents Not Applicable
15 Deoxyglucose Not Applicable
16 Fluorodeoxyglucose F18 Not Applicable
17 calcium heparin
18 Lithium carbonate 554-13-2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Tuberculosis Prevention for HIV Infected Adults Completed NCT00057122 Phase 3 Isoniazid;Rifapentine;Rifampin
2 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
3 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
4 PET/CT in Extrapulmonary TB in HIV Patients: a Clinical Trial Completed NCT02822014 Not Applicable
5 Intervention in the Management of Post-high Tuberculosis Hospital Through Educational Strategy and Oversight Distance Completed NCT02558842 Not Applicable
6 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
7 Paradoxical Reactions in Non Immuno-compromized Patients With Extrapulmonary Tuberculosis Active, not recruiting NCT01252992
8 Effect of Xpert MTB/RIF on Patient Outcomes Active, not recruiting NCT02729532
9 Role of Genexpert in Extra Pulmonary Tuberculosis Not yet recruiting NCT03173261 Not Applicable
10 Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Not yet recruiting NCT03271567
11 A Study on the Safety and Effectiveness of Rilpivirine Hydrochloride (Edurant) Among Adult Filipino Patients With Human Immunodeficiency Virus Type-I Infection Withdrawn NCT01692470 No intervention

Search NIH Clinical Center for Extrapulmonary Tuberculosis

Genetic Tests for Extrapulmonary Tuberculosis

Anatomical Context for Extrapulmonary Tuberculosis

MalaCards organs/tissues related to Extrapulmonary Tuberculosis:

41
Lung, Bone, Testes, T Cells, Kidney, Lymph Node, B Cells

Publications for Extrapulmonary Tuberculosis

Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 405)
# Title Authors Year
1
Fever with pancytopenia: unusual presentation of extrapulmonary tuberculosis: a case report. ( 29506574 )
2018
2
The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis. ( 29950533 )
2018
3
The Use of TB-Specific Antigen/Phytohemagglutinin Ratio for Diagnosis and Treatment Monitoring of Extrapulmonary Tuberculosis. ( 29868010 )
2018
4
Prevalence and risk factors of drug-resistant extrapulmonary tuberculosis. ( 29424965 )
2018
5
Performance of the IS6110-TaqManAr assay in the diagnosis of extrapulmonary tuberculosis from different biological samples. ( 29972564 )
2018
6
Diagnostic accuracy of the loop-mediated isothermal amplification assay for extrapulmonary tuberculosis: A meta-analysis. ( 29944682 )
2018
7
MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. ( 29742144 )
2018
8
Positive outcome of pulmonary tuberculosis associated with extraordinary extensive extrapulmonary tuberculosis in an immunocompetent adult. ( 29900898 )
2018
9
A Hospital-Based Cross-sectional Study on Clinico-demographic Characteristic of Extrapulmonary Tuberculosis Cases Coming to a Tertiary Hospital of Bihar. ( 29899614 )
2018
10
Eosinophilia, a marker of asymptomatic<i>Strongyloides</i>infection, in a young patient with extrapulmonary tuberculosis. ( 29301814 )
2018
11
Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients. ( 29141727 )
2018
12
Evaluation of the Xpert MTB/RIF assay for diagnosis of smear-negative pulmonary and extrapulmonary tuberculosis in Madagascar. ( 29408360 )
2018
13
Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis. ( 29872046 )
2018
14
Index-TB guidelines: Guidelines on extrapulmonary tuberculosis for India. ( 28862176 )
2017
15
Extrapulmonary Tuberculosis of Lymph Node Coexist with Diffuse Large B-cell Lymphoma: A Case Report. ( 29200700 )
2017
16
Detection of ofloxacin resistance by nitrate reductase assay in Mycobacterium tuberculosis isolates from extrapulmonary tuberculosis. ( 28303821 )
2017
17
Immune Reconstitution Inflammatory Syndrome Occurring in a Kidney Transplant Patient with Extrapulmonary Tuberculosis. ( 28367350 )
2017
18
Use of Digital Droplet PCR to Detect Mycobacterium tuberculosis DNA in Whole Blood-Derived DNA Samples from Patients with Pulmonary and Extrapulmonary Tuberculosis. ( 28848722 )
2017
19
Treatment outcome of extrapulmonary tuberculosis under Revised National Tuberculosis Control Programme. ( 28410692 )
2017
20
Identification of Mycobacterium tuberculosis in Clinical Specimens of Patients Suspected of Having Extrapulmonary Tuberculosis by Application of Nested PCR on Five Different Genes. ( 28144587 )
2017
21
Fundus findings in a series of patients with extrapulmonary tuberculosis in Thailand. ( 28450377 )
2017
22
Extrapulmonary tuberculosis in colombian children: Epidemiological and clinical data in a reference hospital. ( 28559513 )
2017
23
Absorption, distribution, and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis. ( 28092695 )
2017
24
Secretion of IFN-I^ Associated with Galectin-9 Production by Pleural Fluid Cells from a Patient with Extrapulmonary Tuberculosis. ( 28657598 )
2017
25
Recovery of Mycobacterium lentiflavum from bronchial lavage during follow-up of an extrapulmonary tuberculosis patient. ( 28776534 )
2017
26
Enigma of Extrapulmonary Tuberculosis: Where Do We Stand? ( 29021926 )
2017
27
Comparative Diagnostic Utility of Neopterin and IFN-I^/IL-2 in Extrapulmonary Tuberculosis. ( 29062177 )
2017
28
Association of Single-Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis. ( 28530443 )
2017
29
Rapid diagnosis of extrapulmonary tuberculosis with Xpert Mycobacterium tuberculosis/rifampicin assay. ( 28708053 )
2017
30
Two cases of tuberculous spondylodiscitis: a rare manifestation of extrapulmonary tuberculosis. ( 28275564 )
2017
31
Delays in diagnosis and treatment of extrapulmonary tuberculosis in Guatemala. ( 28993352 )
2017
32
Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis. ( 29424197 )
2017
33
Concurrent evaluation of microscopic observation of drug susceptibility assay for pulmonary and extrapulmonary tuberculosis. ( 28367022 )
2017
34
Treatment of pulmonary and extrapulmonary tuberculosis. ( 29169641 )
2017
35
First-time detection and identification of the Mycobacterium tuberculosis Complex members in extrapulmonary tuberculosis clinical samples in south Tunisia by a single tube tetraplex real-time PCR assay. ( 28475618 )
2017
36
Reduction in extrapulmonary tuberculosis in context of antiretroviral therapy scale-up in rural South Africa. ( 28748775 )
2017
37
Rapid detection of Mycobacterium tuberculosis and rifampicin resistance in extrapulmonary tuberculosis and sputum smear-negative pulmonary suspects using Xpert MTB/RIF. ( 28425873 )
2017
38
Real-time PCR followed by high-resolution melting curve analysis: A rapid and pragmatic approach for screening of multidrug-resistant extrapulmonary tuberculosis. ( 28802406 )
2017
39
Evaluation of Xpert MTB/RIF for the Diagnosis of Extrapulmonary Tuberculosis in China. ( 27660225 )
2016
40
Application of ultrasound-guided core biopsy to minimize the non-diagnostic results and the requirement of diagnostic surgery in extrapulmonary tuberculosis of the head and neck. ( 26747256 )
2016
41
Association of HIV infection with extrapulmonary tuberculosis: a systematic review. ( 27830524 )
2016
42
Significance of IFN-Eo/IL-2 Ratio as a Circulating Diagnostic Biomarker in Extrapulmonary Tuberculosis. ( 26946082 )
2016
43
Utility of multiplex real-time PCR in the diagnosis of extrapulmonary tuberculosis. ( 27020707 )
2016
44
Diagnostic Accuracy of the Xpert MTB/RIF Assay for Extrapulmonary Tuberculosis in Children with Musculoskeletal Infections. ( 27286562 )
2016
45
Pleural nodules: A rare presentation of extrapulmonary tuberculosis. ( 27891012 )
2016
46
Extrapulmonary Tuberculosis on Chest X-rays. ( 27580562 )
2016
47
Mycobacterium tuberculosis Complex and HIV Co-Infection among Extrapulmonary Tuberculosis Suspected Cases at the University of Gondar Hospital, Northwestern Ethiopia. ( 26950547 )
2016
48
Rapid and Specific Diagnosis of Extrapulmonary Tuberculosis by Immunostaining of Tissues and Aspirates With Anti-MPT64. ( 26766121 )
2016
49
Assessment of Extrapulmonary Tuberculosis in Two Provinces of Turkey. ( 27141492 )
2016
50
Sequelae of extrapulmonary tuberculosis after treatment: Addressing patient needs. ( 28043517 )
2016

Variations for Extrapulmonary Tuberculosis

Expression for Extrapulmonary Tuberculosis

Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.

Pathways for Extrapulmonary Tuberculosis

Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 CCL2 IFNG IL10 IL1B IL1RN MBL2
2
Show member pathways
12.64 CCL2 IFNG IL1B TBP TLR2
3
Show member pathways
12.61 CCL2 IFNG IL10 IL1B MBL2 P2RX7
4
Show member pathways
12.44 CCL2 IFNG IL10 IL1B
5
Show member pathways
12.32 IFNG IL10 IL1B TLR2
6 12.31 CCL2 IFNG IL10 IL1B IL1RN TLR2
7
Show member pathways
12.21 CCL2 IFNG IL1B TLR2
8
Show member pathways
12.12 IFNG IL10 IL1B TLR2
9
Show member pathways
12.11 IFNG IL10 IL1B TLR2
10
Show member pathways
12.07 IL1B IL1RN TIRAP TLR2
11 12.05 IFNG IL10 IL1B TIRAP TLR2
12
Show member pathways
12.03 IFNG IL1B TIRAP TLR2
13 11.96 CCL2 IFNG IL1B
14
Show member pathways
11.95 CCL2 IFNG IL10 IL1B
15 11.88 CCL2 IFNG IL1B
16 11.85 CCL2 IL10 IL1B
17 11.74 IFNG IL10 IL1B TLR2
18 11.69 CCL2 IFNG IL1B TLR2
19 11.68 IFNG IL10 IL1B
20 11.65 IL10 IL1B TIRAP
21 11.63 IFNG IL10 IL1B
22 11.36 CCL2 IL10 IL1B IL1RN
23 11.24 CCL2 IFNG IL1B TLR2
24 11.21 IFNG IL10 IL1B
25 11.13 IFNG IL10 IL1B
26 10.83 CCL2 IL1B
27 10.71 CCL2 IFNG IL10 IL1B TLR2
28 10.65 CCL2 IFNG IL1B TLR2

GO Terms for Extrapulmonary Tuberculosis

Cellular components related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ADA CCL2 IFNG IL10 IL1B IL1RN

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.93 CCL2 IFNG IL10 IL1B IL1RN
2 cytokine-mediated signaling pathway GO:0019221 9.92 CCL2 IL10 IL1B IL1RN
3 positive regulation of gene expression GO:0010628 9.91 IFNG IL1B P2RX7 SLC11A1 TLR2
4 cell surface receptor signaling pathway GO:0007166 9.9 CCL2 IFNG P2RX7 TIRAP
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B TIRAP TLR2
6 cellular response to organic cyclic compound GO:0071407 9.76 CCL2 IL1B P2RX7
7 positive regulation of interleukin-6 production GO:0032755 9.7 IL1B P2RX7 TLR2
8 immune response GO:0006955 9.7 CCL2 IFNG IL10 IL1B IL1RN SLC11A1
9 positive regulation of T cell activation GO:0050870 9.65 ADA CCL2
10 positive regulation of phagocytosis GO:0050766 9.65 IL1B MBL2 SLC11A1
11 defense response to protozoan GO:0042832 9.64 IL10 SLC11A1
12 response to ATP GO:0033198 9.64 IL1B P2RX7
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IFNG IL1B
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 CCL2 TLR2
15 response to bacterium GO:0009617 9.63 CCL2 P2RX7 SLC11A1
16 response to molecule of bacterial origin GO:0002237 9.62 IL10 TLR2
17 defense response to Gram-positive bacterium GO:0050830 9.62 MBL2 P2RX7 TIRAP TLR2
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B
19 cellular response to lipoteichoic acid GO:0071223 9.61 TIRAP TLR2
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 CCL2 IL1B TLR2
21 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.59 IL10 IL1RN
22 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.58 IL1B TIRAP
23 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TIRAP TLR2
24 positive regulation of prostaglandin secretion GO:0032308 9.57 IL1B P2RX7
25 fever generation GO:0001660 9.56 IL1B IL1RN
26 cellular response to bacterial lipopeptide GO:0071221 9.55 TIRAP TLR2
27 positive regulation of interleukin-12 production GO:0032735 9.54 IFNG TIRAP TLR2
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG IL1B
29 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 MBL2 TIRAP
30 response to lipopolysaccharide GO:0032496 9.43 IL10 IL1B P2RX7 SLC11A1 TIRAP TLR2
31 inflammatory response GO:0006954 9.23 CCL2 IL10 IL1B IL1RN P2RX7 SLC11A1

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 IFNG IL10 IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Extrapulmonary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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