EPTB
MCID: EXT033
MIFTS: 49

Extrapulmonary Tuberculosis (EPTB)

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Extrapulmonary Tuberculosis

MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 12 56 15
Tuberculosis, Extrapulmonary 74
Eptb 49

Classifications:



External Ids:

Disease Ontology 12 DOID:0050598
UMLS 74 C0679362

Summaries for Extrapulmonary Tuberculosis

Disease Ontology : 12 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary : Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to miliary tuberculosis and tuberculous peritonitis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Isoniazid and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Extrapulmonary tuberculosis is tuberculosis (TB) within another location in the body than the lungs.... more...

Related Diseases for Extrapulmonary Tuberculosis

Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 miliary tuberculosis 32.4 ADA IFNG
2 tuberculous peritonitis 32.3 ADA IFNG TBP
3 abdominal tuberculosis 32.2 ADA TBP
4 pericardial tuberculosis 31.9 ADA IFNG IL10 TBP
5 pleural tuberculosis 31.8 ADA CCL2 IFNG TBP
6 uveitis 30.4 CCL2 IFNG IL10
7 acquired immunodeficiency syndrome 30.4 IFNG IL10 IL1B
8 tuberculous meningitis 30.1 ADA CCL2 TLR2
9 otitis media 30.1 IL10 IL1B TLR2
10 brucellosis 30.0 IFNG IL10 IL1RN SLC11A1
11 human immunodeficiency virus type 1 29.9 ADA CCL2 IFNG IL10
12 mycobacterium tuberculosis 1 29.8 ADA IFNG IFNGR1 IL10 P2RX7 SLC11A1
13 crohn's disease 29.8 IL10 IL10RA SLC11A1
14 arthritis 29.6 CCL2 IFNG IL10 IL1B IL1RN
15 systemic lupus erythematosus 29.5 CCL2 IFNG IL10 IL1B TLR2
16 meningitis 29.4 ADA CCL2 IFNG IL10 IL1B TLR2
17 pulmonary tuberculosis 29.1 ADA IFNG IFNGR1 IL10 P2RX7 SLC11A1
18 osteomyelitis 29.0 IFNG IFNGR1 IL10 IL1B IL1RN
19 rheumatoid arthritis 28.8 CCL2 IFNG IL10 IL1B IL1RN SLC11A1
20 central nervous system tuberculosis 11.3
21 skeletal tuberculosis 11.3
22 urogenital tuberculosis 11.3
23 lymph node tuberculosis 11.3
24 cephalosporin allergy 10.4 IFNG IL10
25 hyperlucent lung 10.4 IFNG IL10
26 sporotrichosis 10.4 IFNG IL10
27 nickel allergic contact dermatitis 10.4 IFNG IL10
28 staphylococcal toxic shock syndrome 10.4 IFNG IL1B
29 baylisascariasis 10.4 IFNG IL10
30 palladium allergic contact dermatitis 10.4 CCL2 IL10
31 prosthetic joint infection 10.4 IL1B TLR2
32 neurosyphilis 10.4 IL10 TLR2
33 chronic graft versus host disease 10.3 IFNG IL10
34 periodontitis, chronic 10.3 IL1B TLR2
35 clonorchiasis 10.3 IFNG IL10
36 tuberculoid leprosy 10.3 IFNG IL10
37 purulent labyrinthitis 10.3 CCL2 IL1B
38 funisitis 10.3 IL10 IL1B
39 retinitis pigmentosa 73 10.3 CCL2 IL1B
40 haemophilus influenzae 10.3 IL1B TLR2
41 mycoplasma pneumoniae pneumonia 10.3 IFNG IL10 TLR2
42 paracoccidioidomycosis 10.3 IFNG IL10 TLR2
43 opportunistic mycosis 10.3 IFNG IL10 TLR2
44 fascioliasis 10.3 IFNG IL10 IL1B
45 echinococcosis 10.3 IFNG IL10 TLR2
46 crohn's colitis 10.3 IFNG IL1B
47 melioidosis 10.3 IFNG IL10 TLR2
48 eales disease 10.3 IFNG IL10 IL1B
49 filariasis 10.3 IFNG IL10 TLR2
50 inflammatory bowel disease 25, autosomal recessive 10.3 IL10 IL10RA

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis

Symptoms & Phenotypes for Extrapulmonary Tuberculosis

MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ADA IFNG IFNGR1 IL10 IL1B IL1RN
2 cellular MP:0005384 10.11 ADA IFNG IFNGR1 IL10 IL10RA IL1RN
3 hematopoietic system MP:0005397 10.07 ADA IFNG IFNGR1 IL10 IL10RA IL1B
4 growth/size/body region MP:0005378 10.06 ADA IFNG IL10 IL1B IL1RN P2RX7
5 homeostasis/metabolism MP:0005376 10.02 ADA IFNG IFNGR1 IL10 IL10RA IL1B
6 immune system MP:0005387 10 ADA CCL2 IFNG IFNGR1 IL10 IL10RA
7 digestive/alimentary MP:0005381 9.98 ADA IFNG IFNGR1 IL10 IL10RA SLC11A1
8 integument MP:0010771 9.7 IFNG IFNGR1 IL10 IL1B IL1RN P2RX7
9 neoplasm MP:0002006 9.43 IFNG IFNGR1 IL10 IL1B SLC11A1 TLR2
10 skeleton MP:0005390 9.28 ADA IFNG IFNGR1 IL10 IL1B IL1RN

Drugs & Therapeutics for Extrapulmonary Tuberculosis

Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
3
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Lipid Regulating Agents Phase 3
7 Hypolipidemic Agents Phase 3
8 Anti-Infective Agents Phase 3,Not Applicable
9 Antimetabolites Phase 3,Not Applicable
10 Cytochrome P-450 CYP3A Inducers Phase 3
11 Antitubercular Agents Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13
Heparin Approved, Investigational 9005-49-6 46507594 772
14
Lithium carbonate Approved 554-13-2
15 calcium heparin
16 Fluorodeoxyglucose F18 Not Applicable
17 Deoxyglucose Not Applicable
18 Antiviral Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Tuberculosis Prevention for HIV Infected Adults Completed NCT00057122 Phase 3 Isoniazid;Rifapentine;Rifampin
2 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
3 Role of Genexpert in Extra Pulmonary Tuberculosis Unknown status NCT03173261 Not Applicable
4 Paradoxical Reactions in Non Immuno-compromized Patients With Extrapulmonary Tuberculosis Unknown status NCT01252992
5 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
6 PET/CT in Extrapulmonary TB in HIV Patients: a Clinical Trial Completed NCT02822014 Not Applicable
7 Intervention in the Management of Post-high Tuberculosis Hospital Through Educational Strategy and Oversight Distance Completed NCT02558842 Not Applicable
8 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
9 Effect of Xpert MTB/RIF on Patient Outcomes Completed NCT02729532
10 Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Recruiting NCT03271567
11 Bronchial Washings in Sputum Scarce Cases of Pulmonary Tuberculosis Not yet recruiting NCT03732014
12 A Study on the Safety and Effectiveness of Rilpivirine Hydrochloride (Edurant) Among Adult Filipino Patients With Human Immunodeficiency Virus Type-I Infection Withdrawn NCT01692470 No intervention

Search NIH Clinical Center for Extrapulmonary Tuberculosis

Genetic Tests for Extrapulmonary Tuberculosis

Anatomical Context for Extrapulmonary Tuberculosis

MalaCards organs/tissues related to Extrapulmonary Tuberculosis:

42
Lung, Bone, Testes, Kidney, Lymph Node, T Cells, Bone Marrow

Publications for Extrapulmonary Tuberculosis

Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 450)
# Title Authors Year
1
Pachymeningitis with optic neuropathy associated with extrapulmonary tuberculosis and secondary antiphospholipid syndrome. ( 30685445 )
2019
2
Extrapulmonary Tuberculosis Presenting as a Suspected Case of Metastatic Breast Cancer. ( 30931280 )
2019
3
Extrapulmonary Tuberculosis Presenting With Double Vision in a Resource-Limited Tropical Setting. ( 30652664 )
2019
4
Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis. ( 30738907 )
2019
5
Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008-2017. ( 30789144 )
2019
6
Obstetrical and perinatal outcome in pregnant women with extrapulmonary tuberculosis. ( 30797275 )
2019
7
A trial sequential meta-analysis of IFN-γ +874 A>T (rs2430561) gene polymorphism and extrapulmonary tuberculosis risk. ( 30825502 )
2019
8
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting. ( 30846768 )
2019
9
A Case of Extrapulmonary Tuberculosis Two-Ways. ( 30854165 )
2019
10
Patient Health Seeking and Diagnostic Delay in Extrapulmonary Tuberculosis: A Hospital Based Study from Central India. ( 30854235 )
2019
11
Nephrocalcinosis in a patient with extrapulmonary tuberculosis - A rare entity. ( 30911525 )
2019
12
Point-of-care Ultrasound for Pulmonary and Extrapulmonary Tuberculosis in Children. ( 30985549 )
2019
13
Pulmonary Versus Extrapulmonary Tuberculosis Associated Factors: A Case-Case Study. ( 30992667 )
2019
14
Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis. ( 31039752 )
2019
15
Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting. ( 31096926 )
2019
16
Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics. ( 30631629 )
2018
17
Specific cholecystitis: An unusual presentation of extrapulmonary tuberculosis. ( 30243911 )
2018
18
Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients. ( 29141727 )
2018
19
Response to the review article "Imaging in extrapulmonary tuberculosis" from the International Atomic Energy Agency Extra-pulmonary TB Consortium; March 2017, volume 56, pages 237-247. ( 29155088 )
2018
20
Treatment of pulmonary and extrapulmonary tuberculosis. ( 29169641 )
2018
21
Eosinophilia, a marker of asymptomatic Strongyloides infection, in a young patient with extrapulmonary tuberculosis. ( 29301814 )
2018
22
Evaluation of the Xpert MTB/RIF assay for the diagnosis of smear-negative pulmonary and extrapulmonary tuberculosis in Madagascar. ( 29408360 )
2018
23
Prevalence and risk factors of drug-resistant extrapulmonary tuberculosis. ( 29424965 )
2018
24
Fever with pancytopenia: unusual presentation of extrapulmonary tuberculosis: a case report. ( 29506574 )
2018
25
MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. ( 29742144 )
2018
26
The Use of TB-Specific Antigen/Phytohemagglutinin Ratio for Diagnosis and Treatment Monitoring of Extrapulmonary Tuberculosis. ( 29868010 )
2018
27
Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis. ( 29872046 )
2018
28
A Hospital-Based Cross-sectional Study on Clinico-demographic Characteristic of Extrapulmonary Tuberculosis Cases Coming to a Tertiary Hospital of Bihar. ( 29899614 )
2018
29
Positive outcome of pulmonary tuberculosis associated with extraordinary extensive extrapulmonary tuberculosis in an immunocompetent adult. ( 29900898 )
2018
30
Diagnostic accuracy of the loop-mediated isothermal amplification assay for extrapulmonary tuberculosis: A meta-analysis. ( 29944682 )
2018
31
The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis. ( 29950533 )
2018
32
Performance of the IS6110-TaqMan® assay in the diagnosis of extrapulmonary tuberculosis from different biological samples. ( 29972564 )
2018
33
A Review of Extrapulmonary Tuberculosis. ( 29991098 )
2018
34
Prospective Serial FDG PET/CT During Treatment of Extrapulmonary Tuberculosis in HIV-Infected Patients: An Exploratory Study. ( 30015658 )
2018
35
Patterns of uveitis in patients with proven systemic (pulmonary and extrapulmonary) tuberculosis. ( 30022332 )
2018
36
Extrapulmonary Tuberculosis in Federation of Bosnia and Herzegovina. ( 30061808 )
2018
37
Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance. ( 30148542 )
2018
38
Delayed diagnosis of extrapulmonary tuberculosis presenting as fever of unknown origin in an intermediate-burden country. ( 30153813 )
2018
39
Extrapulmonary tuberculosis: atypical presentation in otorhinolaryngology. ( 30158260 )
2018
40
Assessment of Extrapulmonary Tuberculosis Using Gene Xpert MTB/RIF Assay and Fluorescent Microscopy and Its Risk Factors at Dessie Referral Hospital, Northeast Ethiopia. ( 30159328 )
2018
41
Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: A study from Zanzibar. ( 30188947 )
2018
42
Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India. ( 30197919 )
2018
43
Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis. ( 30200884 )
2018
44
Tuberculosis of the elbow: A rare form of presentation of extrapulmonary tuberculosis. ( 30241670 )
2018
45
Diagnostic accuracy of Xpert MTB/RIF assay in extrapulmonary tuberculosis. ( 30429387 )
2018
46
Prevalence of extrapulmonary tuberculosis among people living with HIV/AIDS in sub-Saharan Africa: a systemic review and meta-analysis. ( 30464643 )
2018
47
Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran. ( 30513341 )
2018
48
Extrapulmonary tuberculosis: a debilitating and often neglected public health problem. ( 30573534 )
2018
49
Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: A diagnostic evaluation study. ( 30583052 )
2018
50
Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis. ( 29424197 )
2017

Variations for Extrapulmonary Tuberculosis

Expression for Extrapulmonary Tuberculosis

Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.

Pathways for Extrapulmonary Tuberculosis

Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CCL2 IFNG IFNGR1 IL10 IL10RA IL1B
2
Show member pathways
13.57 CCL2 IFNG IFNGR1 IL10 IL10RA IL1B
3
Show member pathways
13.26 CCL2 IFNG IFNGR1 IL10 IL10RA IL1B
4
Show member pathways
12.97 CCL2 IFNG IFNGR1 IL10 IL1B P2RX7
5
Show member pathways
12.86 CCL2 IFNGR1 IL10RA IL1B TLR2
6
Show member pathways
12.78 IFNG IFNGR1 IL10 IL10RA IL1B
7
Show member pathways
12.58 IFNG IFNGR1 IL1B TBP
8
Show member pathways
12.53 IFNG IFNGR1 IL10 IL10RA
9
Show member pathways
12.5 IFNG IFNGR1 IL10 IL1B TLR2
10
Show member pathways
12.49 CCL2 IFNG IL10 IL10RA IL1B
11 12.42 CCL2 IFNG IL10 IL1B IL1RN TLR2
12
Show member pathways
12.32 IFNG IFNGR1 IL10 IL10RA
13
Show member pathways
12.26 CCL2 IFNG IL1B TLR2
14
Show member pathways
12.12 IFNG IFNGR1 IL1B TLR2
15 12.08 IFNG IFNGR1 TLR2
16 12.07 IL10 IL1B IL1RN
17
Show member pathways
12.07 IFNG IFNGR1 IL10 IL10RA IL1B TLR2
18 12 CCL2 IFNG IL1B
19 11.99 IFNG IFNGR1 IL10 IL10RA IL1B TLR2
20
Show member pathways
11.97 CCL2 IFNG IFNGR1 IL10 IL10RA IL1B
21 11.96 IFNG IFNGR1 IL1B
22
Show member pathways
11.95 IFNG IL1B TLR2
23 11.92 CCL2 IFNG IL1B
24
Show member pathways
11.92 IFNG IFNGR1 IL10 IL1B TLR2
25 11.89 CCL2 IL10 IL1B
26 11.81 IFNG IL10 IL1B TLR2
27 11.79 IFNG IFNGR1 IL10 IL10RA
28 11.77 CCL2 IFNG IL1B TLR2
29 11.75 IFNG IFNGR1 IL1B
30 11.72 IFNG IL10 IL1B
31 11.68 IFNG IL10 IL1B
32 11.44 CCL2 IFNG IL1B TLR2
33 11.4 CCL2 IFNG IL10 IL1B IL1RN
34 11.34 IFNG IFNGR1 IL1B
35 11.33 IFNG IL10 IL1B
36 11.3 IL10 IL10RA IL1B
37 11.17 IFNG IL10 IL1B
38 11.14 CCL2 IL10 IL1B TBP
39 11.07 CCL2 IFNG IL1B TLR2
40 11.04 CCL2 IL10 IL10RA IL1B IL1RN
41 10.86 CCL2 IL1B
42 10.71 CCL2 IFNG IL10 IL1B TLR2

GO Terms for Extrapulmonary Tuberculosis

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.89 CCL2 IFNG IL10 IL1B IL1RN
2 positive regulation of gene expression GO:0010628 9.88 IFNG IL1B P2RX7 SLC11A1 TLR2
3 response to bacterium GO:0009617 9.77 CCL2 P2RX7 SLC11A1
4 cellular response to lipopolysaccharide GO:0071222 9.76 CCL2 IL10 IL1B IL1RN
5 cytokine-mediated signaling pathway GO:0019221 9.73 CCL2 IFNGR1 IL10 IL10RA IL1B IL1RN
6 neutrophil chemotaxis GO:0030593 9.72 CCL2 IL1B IL1RN
7 cellular response to organic cyclic compound GO:0071407 9.71 CCL2 IL1B P2RX7
8 immune response GO:0006955 9.7 CCL2 IFNG IL10 IL1B IL1RN SLC11A1
9 positive regulation of interleukin-12 production GO:0032735 9.63 IFNG TLR2
10 positive regulation of T cell activation GO:0050870 9.62 ADA CCL2
11 defense response to protozoan GO:0042832 9.62 IL10 SLC11A1
12 positive regulation of interleukin-6 production GO:0032755 9.62 IL1B IL1RN P2RX7 TLR2
13 response to ATP GO:0033198 9.61 IL1B P2RX7
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG IL1B
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 IL10 IL1B
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.58 CCL2 TLR2
17 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.58 IFNG IFNGR1
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 CCL2 IL1B TLR2
19 response to molecule of bacterial origin GO:0002237 9.57 IL10 TLR2
20 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.56 IL10 IL1RN
21 response to drug GO:0042493 9.54 ADA IL10 P2RX7
22 positive regulation of prostaglandin secretion GO:0032308 9.52 IL1B P2RX7
23 response to glucocorticoid GO:0051384 9.51 IL10 IL1RN
24 inflammatory response GO:0006954 9.5 CCL2 IL10 IL1B IL1RN P2RX7 SLC11A1
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG IL1B
26 response to lipopolysaccharide GO:0032496 9.1 IL10 IL10RA IL1B P2RX7 SLC11A1 TLR2

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 IFNG IL10 IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Extrapulmonary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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