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EPTB
MCID: EXT033
MIFTS: 46

Extrapulmonary Tuberculosis (EPTB)

Categories: Immune diseases, Infectious diseases, Respiratory diseases
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Aliases & Classifications for Extrapulmonary Tuberculosis

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MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 11 53 14 75
Tuberculosis, Extrapulmonary 71
Eptb 47

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0050598
UMLS 71 C0679362
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Summaries for Extrapulmonary Tuberculosis

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Disease Ontology: 11 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary: Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to urogenital tuberculosis and central nervous system tuberculosis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Isoniazid and Pyrazinamide have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and whole blood, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia: 75 Extrapulmonary tuberculosis is tuberculosis (TB) within a location in the body other than the lungs. It... more...
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Related Diseases for Extrapulmonary Tuberculosis

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Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1105)
# Related Disease Score Top Affiliating Genes
1 urogenital tuberculosis 32.2 IFNG CRP CD4 ALB ADA
2 central nervous system tuberculosis 32.1 TNF IFNG CRP CD4 ADA
3 tuberculous peritonitis 32.1 TBP IFNG CRP CEACAM5 ALB ADA
4 skeletal tuberculosis 32.1 PDE6B IFNG CRP CFHR2
5 lymph node tuberculosis 32.1 TNF IFNG CRP CD4 ALB ADA
6 pericardial tuberculosis 31.8 TNF TBP IFNG CRP CEACAM5 CD4
7 pleural tuberculosis 31.5 ZNF740 TNF TBP IL2 IFNG CRP
8 abdominal tuberculosis 31.5 TNF TBP IFNG GPT CRP CEACAM5
9 lymphadenitis 31.1 TNF IL6 IL10 IFNG CRP CCR6
10 pleurisy 31.0 TNF IFNG CRP ADA
11 miliary tuberculosis 30.9 TNF PDE6B IL4 IL2 IL10 IFNG
12 human immunodeficiency virus type 1 30.9 IL2 IL10 IFNG CD4
13 renal tuberculosis 30.8 CRP ALB
14 pericarditis 30.8 TNF IL6 IFNG CRP ADA
15 cervical adenitis 30.6 TNF PDE6B IFNG CRP CD4
16 intestinal tuberculosis 30.6 TNF IFNG CRP CD4 ALB ADA
17 nutritional deficiency disease 30.5 IL6 CRP CCR6 ALB
18 pulmonary tuberculosis 30.5 TNF TLR2 IL6 IL4 IL2 IL10
19 fasciitis 30.5 TNF IL6 IL2 IFNG
20 histoplasmosis 30.4 TNF IFNG CD4 CCR6
21 multidrug-resistant tuberculosis 30.4 ZNF740 TNF IL10 IFNG CD8A CD4
22 ocular tuberculosis 30.3 ZNF740 IFNG CD4
23 synovitis 30.3 TNF IL6 IL10 CRP
24 chronic meningitis 30.3 CRP CD4 ALB
25 acquired immunodeficiency syndrome 30.3 TNF IL6 IL2 IL10 IFNG CRP
26 cholecystitis 30.3 GPT CRP ALB
27 asphyxia neonatorum 30.2 IL6 CRP ALB
28 inappropriate adh syndrome 30.2 IL6 CRP ALB
29 headache 30.2 TNF IL2 ALB
30 hypersplenism 30.2 GPT CD4 ALB
31 erythema nodosum 30.2 TNF IL6 IL10 IFNG CRP
32 alcohol use disorder 30.2 TNF IL6 GPT CRP CD4 CCR6
33 chronic kidney disease 30.2 TNF IL6 CRP CFHR2 CCR6 ALB
34 back pain 30.2 IL6 IL10 CRP
35 mediastinitis 30.2 IL6 CRP CD4 ALB
36 osteomyelitis 30.1 TNF TLR2 IL6 IL4 IL10 IFNG
37 myositis 30.1 TNF IL6 IL17A IFNG
38 necrotizing fasciitis 30.1 TNF IL6 CRP ALB
39 hyperuricemia 30.1 GPT CRP ALB ADA
40 pancytopenia 30.1 IL6 IFNG GPT CRP CD8A CD4
41 suppurative lymphadenitis 30.1 PDE6B IFNG CRP CD8A CD4
42 mycobacterium tuberculosis 1 30.1 TNF TLR2 PDE6B IL6 IL4 IL17A
43 pyuria 30.0 IL6 GPT CRP ALB
44 spondylitis 30.0 TNF IL6 IL17A IL10 IFNG CRP
45 obstructive jaundice 30.0 GPT CRP CEACAM5 ALB
46 vasculitis 30.0 TNF IL6 IL17A IL10 CRP
47 macs syndrome 30.0 TNF IL10 IFNG CD8A CD4
48 myelitis 30.0 TNF IL6 IL17A IL10 CCR6
49 splenic abscess 30.0 GPT CRP CEACAM5 CD8A CD4 ALB
50 drug-induced hepatitis 30.0 TNF GPT CRP CD4 ALB

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis
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Symptoms & Phenotypes for Extrapulmonary Tuberculosis

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MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 ADA ALB CCR6 CD4 CEACAM5 CRP
2 endocrine/exocrine gland MP:0005379 10.29 ADA ALB CD4 CD8A CEACAM5 IFNG
3 immune system MP:0005387 10.27 ADA ALB CCR6 CD4 CD8A CEACAM5
4 cellular MP:0005384 10.25 ADA ALB CD4 CD8A CEACAM5 IFNG
5 digestive/alimentary MP:0005381 10.23 ADA ALB CD4 CEACAM5 IFNG IL10
6 cardiovascular system MP:0005385 10.22 ADA ALB CCR6 CEACAM5 CRP IFNG
7 liver/biliary system MP:0005370 10.21 ADA ALB IFNG IL10 IL17A IL2
8 neoplasm MP:0002006 10.15 ALB CEACAM5 IFNG IL10 IL2 IL6
9 no phenotypic analysis MP:0003012 10.14 CD4 IFNG IL10 IL17A IL2 IL4
10 muscle MP:0005369 10.13 ADA ALB CEACAM5 IFNG IL10 IL6
11 hematopoietic system MP:0005397 10.03 ADA CCR6 CD4 CD8A CEACAM5 IFNG
12 respiratory system MP:0005388 9.97 ADA IFNG IL10 IL17A IL2 IL4
13 skeleton MP:0005390 9.96 ADA GPT IFNG IL10 IL17A IL4
14 mortality/aging MP:0010768 9.8 ADA ALB CD4 CD8A CEACAM5 IFNG
15 integument MP:0010771 9.32 CD4 CD8A IFNG IL10 IL17A IL4
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Drugs & Therapeutics for Extrapulmonary Tuberculosis

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Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 2 54-85-3 3767
2
Pyrazinamide Approved, Investigational Phase 2 98-96-4 1046
3
Ethambutol Approved Phase 2 74-55-5, 1070-11-7 3279 14052
4
Rifampicin Approved Phase 2 13292-46-1 135512673 5381226 135900090
5 Anti-Infective Agents Phase 2
6 Anti-Bacterial Agents Phase 2
7 Antitubercular Agents Phase 2
8 Antibiotics, Antitubercular Phase 2
9
Lithium carbonate Approved 554-13-2
10 Antiviral Agents
11 Fluorodeoxyglucose F18
12 Antimetabolites
13 Deoxyglucose

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety of Rifampicin at High Dose for the Treatment of Adult Subjects With Complex Drug Susceptible Pulmonary and Extrapulmonary Tuberculosis Not yet recruiting NCT04768231 Phase 2 Rifampin
2 Evaluation of TB-antigen Responsive T Cell Markers in Diagnosis of Tuberculosis and Extrapulmonary Tuberculosis Unknown status NCT04148053
3 Point-of-care Strategies to Improve Tuberculosis Care Among Severely Immunosuppressed HIV-infected Patients Completed NCT04122404
4 FDG-PET/CT: a Tool in Diagnosis and Treatment Response Monitoring of Extrapulmonary Tuberculosis in HIV Patients Completed NCT02822014
5 Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196
6 Paradoxical Reactions During Anti-mycobacterial Treatment of Extrapulmonary Tuberculosis in Non Immuno-compromized Patients : Clinical, Radiological et Immunological Completed NCT01252992
7 Detection of Circulating Mycobacterium Tuberculosis Antigen Peptides for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Completed NCT03271567

Search NIH Clinical Center for Extrapulmonary Tuberculosis

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Genetic Tests for Extrapulmonary Tuberculosis

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Anatomical Context for Extrapulmonary Tuberculosis

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Organs/tissues related to Extrapulmonary Tuberculosis:

MalaCards : Lung, Lymph Node, Whole Blood, T Cells, Bone Marrow, Liver, Breast
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Publications for Extrapulmonary Tuberculosis

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Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 2686)
# Title Authors PMID Year
1
[Adenosine deaminase in the complex diagnosis of different forms of extrapulmonary tuberculosis]. 53 62
17195584 2006
2
Extrapulmonary tuberculosis: an overview. 53 62
16300038 2005
3
[Cardiac tamponade with paroxysmal atrial flutter controlled by antituberculous therapy]. 53 62
14999926 2004
4
Hospital variation in extremely preterm birth. 62
36104499 2022
5
Central nervous system tuberculosis in immunocompetent patients: Two case reports with literature review. 62
36204408 2022
6
Detection of Mycobacterium tuberculosis and rifampicin resistance by Xpert® MTB/RIF assay among presumptive tuberculosis patients in Addis Ababa, Ethiopia from 2014 to 2021. 62
36247095 2022
7
Clinical analysis of pregnancy complicated with miliary tuberculosis. 62
34955089 2022
8
Epidemiology of extrapulmonary tuberculosis among pediatric inpatients in mainland China: a descriptive, multicenter study. 62
35290153 2022
9
Ultrasound in managing extrapulmonary tuberculosis: A randomised, controlled, parallel, superiority, open-label trial. 62
36331957 2022
10
Epidemiology of extrapulmonary tuberculosis in central Guangxi from 2016 to 2021. 62
36445622 2022
11
Prostate Tuberculosis Masquerading as Prostate Carcinoma: A Rare Case Report. 62
36465223 2022
12
[Tuberculosis in adulthood - The Sk2-Guideline of the German Central Committee against Tuberculosis (DZK) and the German Respiratory Society (DGP) for the diagnosis and treatment of adult tuberculosis patients]. 62
36384164 2022
13
A Prospective Observational Study of Hepatic Dysfunction in Children on Antitubercular Drugs. 62
35867272 2022
14
Association of Underlying Comorbidities and Sites of tuberculosis: an analysis using surveillance data. 62
36371212 2022
15
Clinical forms and diagnosis of tuberculosis in children and adolescents during the COVID-19 pandemic. 62
36449819 2022
16
Primary extensive perianal cutaneous tuberculosis: A challenging diagnosis. Case report and a review of the literature. 62
36462576 2022
17
BaeR overexpression enhances the susceptibility of acrB deleted Salmonella enterica serovar Typhimurium to polymyxin. 62
36095878 2022
18
Pregnancy-Related Tuberculous Meningitis and Immune Reconstitution Inflammatory Syndrome: A Case Series and Systematic Review. 62
36267255 2022
19
Clinical Management of Pathogen-Negative Tuberculous Meningitis in Adults: A Series Case Study. 62
36362480 2022
20
Surgical resection of a tuberculoma in the diaphragm: a case report. 62
36239874 2022
21
A Timely Burst: Tuberculous Retropharyngeal Abscess. 62
36452768 2022
22
A case of concurrent gastrointestinal, peritoneal and urinary bladder tuberculosis. 62
36460413 2022
23
Performance of Xpert MTB/RIF for Diagnosis of Tuberculosis in HIV-Infected People in China: A Retrospective, Single-Center Study. 62
36196026 2022
24
The influence of polycystic ovarian syndrome on obstetric and neonatal outcomes after frozen-thawed embryo transfer. 62
35831222 2022
25
Epidemiological and Cytokine Profile of Patients with Pulmonary and Extrapulmonary Tuberculosis in a Population of the Brazilian Amazon. 62
36296351 2022
26
Occurrence of extrapulmonary tuberculosis is associated with geographical origin: spatial characteristics of the Frankfurt TB cohort 2013-2018. 62
36181634 2022
27
Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique. 62
36198860 2022
28
Effectiveness of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis at various stand-alone laboratories in Delhi. 62
36460384 2022
29
Extrapulmonary tuberculosis in the head and neck-a rare situation deserves attention. 62
36299317 2022
30
Clinicodemographic profile and outcome of tuberculosis treatment in TB-HIV co-infected patients receiving daily ATT under a single window TB/HIV services delivery initiative. 62
36200689 2022
31
Incidence and Mortality of Extrapulmonary Tuberculosis in Ukraine: Analysis of National Surveillance Data. 62
34929028 2022
32
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. 62
35961354 2022
33
Extrapulmonary tuberculosis presentation in the form of a chest wall abscess with no pulmonary involvement in the UK: a case report. 62
36158246 2022
34
Lateral flow urine lipoarabinomannan assay for extrapulmonary tuberculosis diagnosis in adults who are HIV-positive. 62
35690363 2022
35
Chest wall tumor tuberculosis in Indonesian adolescent: A rare case. 62
36380548 2022
36
The Case of the Young Male with a Longstanding History of Dyspeptic Symptoms: Peritoneal Tuberculosis. 62
36321009 2022
37
Genetic diversity and drug resistance profiles of Mycobacterium tuberculosis complex isolates from patients with extrapulmonary tuberculosis in Ghana and their associated host immune responses. 62
35813561 2022
38
Drug-resistance and its impact on cutaneous tuberculosis. 62
36304661 2022
39
Review and Updates on the Diagnosis of Tuberculosis. 62
36233689 2022
40
Interleukin-1 receptor antagonist anakinra as treatment for paradoxical responses in HIV-negative tuberculosis patients: A case series. 62
36041428 2022
41
Xpert MTB/RIF Ultra outperformed the Xpert assay in tuberculosis lymphadenitis diagnosis: a prospective head-to-head cohort study. 62
35872095 2022
42
Rapid Deterioration of a Cervical Tuberculosis Disease in a Young Immunocompetent Patient: A Case Report. 62
36299922 2022
43
Pulmonary Tuberculosis With Tuberculous Right Wrist Tenosynovitis, Hepatitis C, and Mild COVID-19 in a Kidney Transplant Indian Male: World's First Case. 62
36225505 2022
44
Molecular genetic tests GeneXpert MTB/RIF and Xpert MTB/RIF (Ultra) in the diagnosis of tuberculosis (review of literature). 62
36099465 2022
45
Correlation of serum amyloid A1 and interleukin-1beta in response to anti-tubercular therapy. 62
35452629 2022
46
Interleukin 32 as a Potential Marker for Diagnosis of Tuberculous Pleural Effusion. 62
35880892 2022
47
TB disease patterns by HIV and diabetes status. 62
35898145 2022
48
Primary hepatic tuberculosis presenting as fever of unknown origin diagnosed by Positron emission tomography/computed tomography scan (PET/CT). 62
36352925 2022
49
Xpert MTB/RIF Assay for the Diagnosis of Lymph Node Tuberculosis in Children: A Systematic Review and Meta-Analysis. 62
35956230 2022
50
Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples. 62
35986185 2022
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Variations for Extrapulmonary Tuberculosis

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Expression for Extrapulmonary Tuberculosis

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Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.
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Pathways for Extrapulmonary Tuberculosis

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Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14 TNF TLR2 IL6 IL4 IL2 IL17A
2
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.67 TNF TBP IL6 IL4 IL2 IL17A
3
TGF-Beta Pathway 64
Show member pathways
 13.56 TNF IL6 IL4 IL2 IL17A IL10
4
Akt Signaling 64
Show member pathways
 13.45 CCR6 CD4 IL10 IL17A IL2 IL4
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.36 CD4 IFNG IL10 IL17A IL2 IL4
6
PAK Pathway 64
Show member pathways
 13.34 TNF IL6 IL4 IL2 IL17A IL10
7
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.69 TNF IL6 IL4 IL2 IL17A IL10
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.67 TNF IL6 IL2 IL17A IL10 IFNG
9
Complement cascade 66
Show member pathways
 12.65 TLR2 IFNG CRP CFHR2 ALB
10
NF-kappaB Signaling 3
12.64 TNF TLR2 IL4 IL2 IL17A IL10
11
Bacterial infections in CF airways 22
Show member pathways
 12.47 TNF TLR2 IL6 IL4 IFNG
12
IL-17 Family Signaling Pathways 65
Show member pathways
 12.3 TNF TLR2 IL6 IL17A
13
T-cell activation SARS-CoV-2 74
Show member pathways
 12.24 TNF IL4 IL2 IL17A IL10 IFNG
14
Immune response CD16 signaling in NK cells 22
Show member pathways
 12.23 IFNG IL2 IL4 TNF
15
Colorectal Cancer Metastasis 64
12.22 TNF TLR2 IL6 IFNG
16
Neuroinflammation and glutamatergic signaling 74
12.18 TNF IL6 IL4 IL10 IFNG
17
Spinal cord injury 74
12.09 IFNG IL2 IL4 IL6 TNF
18
IL12-mediated signaling events 61
Show member pathways
 12.07 IL4 IL2 IFNG CD8A CD4
19
Interleukin-4 and Interleukin-13 signaling 66
12.04 TNF IL6 IL4 IL17A IL10
20
Allograft rejection 74
11.98 TNF IL4 IL2 IL17A IL10 IFNG
21
Th17 Differentiation 65
Show member pathways
 11.96 TLR2 IL6 IL4 IL17A IFNG CD4
22
IL27-mediated signaling events 61
Show member pathways
 11.92 TNF TLR2 IL6 IL2 IL17A IL10
23
Glucocorticoid receptor regulatory network 61
11.88 TBP IL6 IL4 IL2 IFNG
24
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.87 CD4 CD8A CEACAM5 IFNG IL10 IL2
25
Acute viral myocarditis 74
11.86 IL6 IL2 IL10 IFNG CD4
26
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.85 IL6 CRP CD8A CD4
27
Dendritic Cells Developmental Lineage Pathway 65
11.85 TNF IL6 IL2 IL10 IFNG CD8A
28
AP-1 transcription factor network 61
11.81 IFNG IL10 IL2 IL4 IL6
29
Th17 cell differentiation pathway 74
11.81 CD4 IFNG IL17A IL2 IL4 IL6
30
Extrafollicular B cell activation by SARS-CoV-2 74
11.8 TNF IL6 IL4 IL2 IL10 IFNG
31
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.78 TNF IL4 IL2 IFNG
32
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.75 TNF IL6 IL2 IFNG
33
Lung fibrosis 74
11.7 TNF IL6 IL4
34
miRNAs involvement in the immune response in sepsis 74
11.69 TNF IL6 IL10
35
IL 10 signaling pathway 67
11.68 TNF IL6 IL10
36
Inflammatory bowel disease signaling 74
Show member pathways
 11.68 IFNG IL10 IL2 IL4 IL6 TLR2
37
THC Differentiation Pathway 64
11.64 TNF IL4 IL2 IL10 IFNG CD4
38
SHP2 signaling 61
11.62 IL6 IL2 IFNG
39
Th2 Differentiation 65
11.61 IL4 IL2 IL10 IFNG CD4
40
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.59 TNF IL6 IFNG
41
MSP-RON Signaling 64
11.56 TNF TLR2 IFNG
42
Interleukin-10 signaling 66
11.55 TNF IL6 IL10
43
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.52 TNF IL6 IFNG
44
Innate Lymphoid Cells Differentiation 65
11.51 CCR6 CD4 CD8A IFNG IL10 IL17A
45
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
Show member pathways
 11.47 TNF IL2 IL10 IFNG
46
IL-10 Pathway 64
11.41 TNF IL6 IL10
47
Development and heterogeneity of the ILC family 74
11.41 TNF IL6 IL4 IL17A IFNG
48
Inflammatory response pathway 74
11.38 IL4 IL2 IFNG
49
OX40 Pathway 64
11.32 IL4 IL2 IL10 IFNG
50
Prostaglandin signaling 74
11.31 TNF IL6 IL17A
Sources

GO Terms for Extrapulmonary Tuberculosis

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Cellular components related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.98 ALB CFHR2 CRP GPT IFNG IL10
2 external side of plasma membrane GO:0009897 9.93 TNF IL17A CD8A CD4 CCR6 ADA
3 extracellular region GO:0005576 9.7 TNF IL6 IL4 IL2 IL17A IL10

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 10.23 ADA IL10 IL2 IL4
2 positive regulation of inflammatory response GO:0050729 10.22 TNF TLR2 IL2 IFNG
3 positive regulation of tumor necrosis factor production GO:0032760 10.21 IFNG IL17A IL6 TLR2
4 calcium-mediated signaling GO:0019722 10.16 TNF CD4 CCR6 ADA
5 positive regulation of interleukin-12 production GO:0032735 10.13 TLR2 IL17A IFNG
6 defense response to Gram-positive bacterium GO:0050830 10.13 CRP IL17A IL6 TLR2 TNF
7 positive regulation of interleukin-10 production GO:0032733 10.12 TLR2 IL6 IL4
8 positive regulation of interleukin-1 beta production GO:0032731 10.11 IFNG IL17A IL6 TNF
9 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.1 TNF IL6 IL10
10 humoral immune response GO:0006959 10.1 TNF IL6 IFNG CCR6
11 negative regulation of apoptotic process GO:0043066 10.1 TNF IL6 IL4 IL2 IL10 CEACAM5
12 liver regeneration GO:0097421 10.08 TNF IL6 IL10
13 T cell activation GO:0042110 10.06 IL4 CD8A CD4 ADA
14 positive regulation of immunoglobulin production GO:0002639 10.05 IL6 IL2 IL10
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.04 IL17A IL6 TNF
16 positive regulation of osteoclast differentiation GO:0045672 10.02 TNF IL17A IFNG
17 positive regulation of interleukin-6 production GO:0032755 10.02 IFNG IL17A IL6 TLR2 TNF
18 positive regulation of chemokine production GO:0032722 10.01 TNF TLR2 IL6 IFNG
19 positive regulation of mononuclear cell migration GO:0071677 9.95 TNF IL4
20 negative regulation of cytokine production involved in immune response GO:0002719 9.95 TNF IL10
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.95 IL4 IL10 IFNG
22 positive regulation of T cell differentiation GO:0045582 9.94 IL4 IL2 ADA
23 regulation of isotype switching GO:0045191 9.92 IL4 IL10
24 positive regulation of plasma cell differentiation GO:1900100 9.9 IL2 IL10
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.89 TNF IFNG
26 positive regulation of nitrogen compound metabolic process GO:0051173 9.88 TNF IFNG
27 negative regulation of lipid storage GO:0010888 9.85 TNF IL6 CRP
28 positive regulation of vitamin D biosynthetic process GO:0060557 9.84 TNF IFNG
29 chronic inflammatory response to antigenic stimulus GO:0002439 9.83 TNF IL10
30 microglial cell activation GO:0001774 9.76 TNF TLR2 IL4 IFNG
31 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IFNG IL2 IL4 IL6 TNF
32 immune response GO:0006955 9.58 TNF TLR2 IL6 IL4 IL2 IL17A

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.47 TNF IL6 IL4 IL2 IL17A IL10
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Sources for Extrapulmonary Tuberculosis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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