Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
EPTB
MCID: EXT033
MIFTS: 46

Extrapulmonary Tuberculosis (EPTB)

Categories: Immune diseases, Infectious diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Extrapulmonary Tuberculosis

About this section

MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 12 55 15
Tuberculosis, Extrapulmonary 72
Eptb 48

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050598
UMLS 72 C0679362
Sources

Summaries for Extrapulmonary Tuberculosis

About this section
Disease Ontology : 12 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary : Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to miliary tuberculosis and tuberculous peritonitis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone, and related phenotypes are cellular and cardiovascular system

Wikipedia : 75 Extrapulmonary tuberculosis is tuberculosis (TB) within another location in the body than the lungs.... more...

Sources

Related Diseases for Extrapulmonary Tuberculosis

About this section

Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 miliary tuberculosis 33.4 IFNG ADA
2 tuberculous peritonitis 32.7 TBP IFNG ADA
3 abdominal tuberculosis 32.6 TBP ADA
4 pleural tuberculosis 32.1 TBP IFNG CCL2 ADA
5 pericardial tuberculosis 31.7 TBP IL10 IFNG ADA
6 tuberculous meningitis 31.2 TLR2 CCL2 ADA
7 pericarditis 31.1 IL1B IFNG ADA
8 uveitis 31.0 IL10 IFNG CCL2
9 pleurisy 30.9 IFNG CCL2 ADA
10 brucellosis 30.7 SLC11A1 IL10 IFNG
11 otitis media 30.5 TLR2 IL1B IL10
12 osteomyelitis 30.4 IL1B IL10 IFNGR1 IFNG
13 lymphadenitis 30.4 SLC11A1 IL1B IL10 IFNGR1 IFNG
14 arthritis 30.3 IL1B IL10 IFNG CCL2
15 hemophagocytic lymphohistiocytosis 30.3 IL10 IFNG ADA
16 acquired immunodeficiency syndrome 30.3 IL1B IL10 IFNG CD4
17 viral encephalitis 30.3 IL1B IL10 CCL2
18 pyelonephritis 30.2 IL1B IL10 CCL2
19 peritonitis 30.2 TLR2 IL1B IL10 CCL2 ADA
20 mycobacterium tuberculosis 1 30.2 TLR2 SLC11A1 P2RX7 IL10 IFNGR1 IFNG
21 lung disease 30.1 TLR2 IL1B IL10 CCL2
22 toxic shock syndrome 30.0 TLR2 IL1B IL10 IFNG
23 toxoplasmosis 30.0 TLR2 IL1B IL10 IFNG
24 leprosy 3 30.0 TLR2 SLC11A1 IL10 IFNG
25 pulmonary tuberculosis 29.9 TLR2 SLC11A1 P2RX7 IL10 IFNGR1 IFNG
26 gastrointestinal tuberculosis 29.9 TBP ADA
27 post-transplant lymphoproliferative disease 29.8 SLC11A1 IL10RA IL10
28 crohn's disease 29.6 SLC11A1 IL10RA IL10
29 pleural disease 29.6 TBP IL1B ADA
30 meningitis 29.5 TLR2 IL1B IL10 IFNG CCL2 ADA
31 human immunodeficiency virus type 1 29.5 IL10 IFNG CD4 CCL2 ADA
32 systemic lupus erythematosus 29.2 TLR2 IL1B IL10 IFNG CCL2
33 lymph node tuberculosis 11.7
34 skeletal tuberculosis 11.7
35 central nervous system tuberculosis 11.7
36 urogenital tuberculosis 11.7
37 cephalosporin allergy 10.7 IL10 IFNG
38 hyperlucent lung 10.6 IL10 IFNG
39 sporotrichosis 10.6 IL10 IFNG
40 staphylococcal toxic shock syndrome 10.6 IL1B IFNG
41 nickel allergic contact dermatitis 10.6 IL10 IFNG
42 baylisascariasis 10.6 IL10 IFNG
43 prosthetic joint infection 10.6 TLR2 IL1B
44 neurosyphilis 10.6 TLR2 IL10
45 palladium allergic contact dermatitis 10.6 IL10 CCL2
46 clonorchiasis 10.5 IL10 IFNG
47 periodontitis, chronic 10.5 TLR2 IL1B
48 tuberculoid leprosy 10.5 IL10 IFNG
49 purulent labyrinthitis 10.5 IL1B CCL2
50 funisitis 10.5 IL1B IL10

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis
Sources

Symptoms & Phenotypes for Extrapulmonary Tuberculosis

About this section

MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 ADA CD4 IFNG IFNGR1 IL10 IL10RA
2 cardiovascular system MP:0005385 10.08 ADA IFNG IFNGR1 IL10 IL1B P2RX7
3 hematopoietic system MP:0005397 10.07 ADA CD4 IFNG IFNGR1 IL10 IL10RA
4 growth/size/body region MP:0005378 10.06 ADA CD4 IFNG IL10 IL1B P2RX7
5 digestive/alimentary MP:0005381 10.03 ADA CD4 IFNG IFNGR1 IL10 IL10RA
6 homeostasis/metabolism MP:0005376 10.02 ADA CD4 IFNG IFNGR1 IL10 IL10RA
7 immune system MP:0005387 10 ADA CCL2 CD4 IFNG IFNGR1 IL10
8 integument MP:0010771 9.7 CD4 IFNG IFNGR1 IL10 IL1B P2RX7
9 neoplasm MP:0002006 9.43 IFNG IFNGR1 IL10 IL1B SLC11A1 TLR2
10 skeleton MP:0005390 9.23 ADA IFNG IFNGR1 IL10 IL1B P2RX7
Sources

Drugs & Therapeutics for Extrapulmonary Tuberculosis

About this section

Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Antitubercular Agents Phase 3
7 Hormone Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Methylprednisolone Acetate Phase 3
11 Antiemetics Phase 3
12 Hormones Phase 3
13 glucocorticoids Phase 3
14 Neuroprotective Agents Phase 3
15 Immunologic Factors Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Protective Agents Phase 3
19 Prednisolone acetate Phase 3
20 Vaccines Phase 3
21 Autonomic Agents Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
23
Heparin Approved, Investigational 9005-49-6 46507594 772
24
Lithium carbonate Approved 554-13-2
25 Anti-Bacterial Agents
26 calcium heparin
27 Fluorodeoxyglucose F18
28 Antimetabolites
29 Deoxyglucose
30 Anti-Infective Agents
31 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centric Study on Treatment of Abdominal Tuberculosis (Intestinal or Peritoneal): A Randomized Controlled Trial to Compare the 6 Months of Cat I Treatment With 9 Months of Cat I Treatment (Extension for 3 Months) in Abdominal Tuberculosis Under the Revised National Tuberculosis Control Program Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
2 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
3 Paradoxical Reactions During Anti-mycobacterial Treatment of Extrapulmonary Tuberculosis in Non Immuno-compromized Patients : Clinical, Radiological et Immunological Unknown status NCT01252992
4 Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196
5 Evaluation of Efficacy of Thrice Weekly DOTS Regimen in Tubercular Pleural Effusion at 6 Months Completed NCT01560078
6 FDG-PET/CT: a Tool in Diagnosis and Treatment Response Monitoring of Extrapulmonary Tuberculosis in HIV Patients Completed NCT02822014
7 Diagnosis of Tuberculous Meningitis by a Secretory Antigenic Target 6 (ESAT-6) in CSF Completed NCT01371916
8 Detection of Circulating Mycobacterium Tuberculosis Antigen Peptides for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Recruiting NCT03271567

Search NIH Clinical Center for Extrapulmonary Tuberculosis

Sources

Genetic Tests for Extrapulmonary Tuberculosis

About this section
Sources

Anatomical Context for Extrapulmonary Tuberculosis

About this section

MalaCards organs/tissues related to Extrapulmonary Tuberculosis:

41
Lung, Testes, Bone, Lymph Node, Liver, T Cells, Breast
Sources

Publications for Extrapulmonary Tuberculosis

About this section

Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 1872)
# Title Authors PMID Year
1
[Adenosine deaminase in the complex diagnosis of different forms of extrapulmonary tuberculosis]. 9 38
17195584 2006
2
Extrapulmonary tuberculosis: an overview. 9 38
16300038 2005
3
[Cardiac tamponade with paroxysmal atrial flutter controlled by antituberculous therapy]. 9 38
14999926 2004
4
Patterns of uveitis in patients with proven systemic (pulmonary and extrapulmonary) tuberculosis. 38
30022332 2019
5
Evaluation of Clinical and Laboratory Characteristics of Children with Pulmonary and Extrapulmonary Tuberculosis. 38
31375006 2019
6
Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a diagnostic evaluation study. 38
30583052 2019
7
Clinical value of interferon-γ release assay in the diagnosis of active tuberculosis. 38
31363369 2019
8
Internal Mammary Lymph Node Visualization as a Sentinel Sonographic Sign of Tuberculous Pleurisy. 38
31238381 2019
9
Multiplex Real-Time PCR-shortTUB Assay for Detection of the Mycobacterium tuberculosis Complex in Smear-Negative Clinical Samples with Low Mycobacterial Loads. 38
31189585 2019
10
Impact of ultrasound on management for dyspnea presentations in a Rwandan emergency department. 38
31432282 2019
11
Genetic Polymorphisms of miR-149 Associated with Susceptibility to Both Pulmonary and Extrapulmonary Tuberculosis. 38
31219360 2019
12
Thymic Tuberculosis Shown on FDG PET/CT Despite Coexisting Pulmonary Tuberculosis With No Increased FDG Activity. 38
31283603 2019
13
Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children. 38
31299414 2019
14
Multicentre evaluation of Xpert MTB/RIF assay in detecting urinary tract tuberculosis with urine samples. 38
31363115 2019
15
Changes in inflammatory protein and lipid mediator profiles persist after antitubercular treatment of pulmonary and extrapulmonary tuberculosis: A prospective cohort study. 38
31226436 2019
16
Severe disseminated tuberculosis in HIV-negative refugees. 38
31182290 2019
17
[Incremental cost-effectiveness of the second Xpert MTB/RIF assay for detection of Mycobacterium tuberculosis]. 38
31189229 2019
18
A real-world experience with 6 months of antitubercular therapy in abdominal tuberculosis. 38
31276036 2019
19
Association between P2X7 Polymorphisms and Susceptibility to Tuberculosis: An Updated Meta-Analysis of Case-Control Studies. 38
31234470 2019
20
Imaging in Pediatric Extra-Pulmonary Tuberculosis. 38
30697676 2019
21
Abdominal tuberculosis in a spigelian hernia. 38
31092481 2019
22
A trial sequential meta-analysis of IFN-γ +874 A>T (rs2430561) gene polymorphism and extrapulmonary tuberculosis risk. 38
30825502 2019
23
Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting. 38
31096926 2019
24
Point-of-care Ultrasound for Pulmonary and Extrapulmonary Tuberculosis in Children. 38
30985549 2019
25
Harnessing donor unrestricted T-cells for new vaccines against tuberculosis. 38
31040086 2019
26
Delayed Diagnosis of Spinal Tuberculosis in a 44-year-old Male with Acute on Chronic Low Back Pain. 38
31061963 2019
27
Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis. 38
30738907 2019
28
Pachymeningitis with optic neuropathy associated with extrapulmonary tuberculosis and secondary antiphospholipid syndrome. 38
30685445 2019
29
Increased vitamin D receptor expression from macrophages after stimulation with M. tuberculosis among persons who have recovered from extrapulmonary tuberculosis. 38
31039752 2019
30
Focused ultrasound to diagnose HIV-associated tuberculosis (FASH) in the extremely resource-limited setting of South Sudan: a cross-sectional study. 38
30944140 2019
31
The determinants and impact of diagnostic delay in lymphoma in a TB and HIV endemic setting. 38
31023278 2019
32
Sonography to Rule Out Tuberculosis in Sub-Saharan Africa: A Prospective Observational Study. 38
31041350 2019
33
Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008-2017. 38
30789144 2019
34
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting. 38
30846768 2019
35
Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran. 38
30513341 2019
36
Microbiological evaluation of clinically suspected cases of tubercular lymphadenopathy by cytology, culture, and smear microscopy - A hospital-based study from Northern India. 38
31041209 2019
37
The rapid molecular test Xpert MTB/RIF ultra: towards improved tuberculosis diagnosis and rifampicin resistance detection. 38
30928564 2019
38
BCG overexpressing an endogenous STING agonist provides enhanced protection against pulmonary tuberculosis. 38
30901058 2019
39
Ischemic stroke and disseminated tuberculosis in a child living with human immunodeficiency virus: a case report and review of the literature. 38
30782204 2019
40
A Case of Extrapulmonary Tuberculosis Two-Ways. 38
30854165 2019
41
APACHE-II score for anti-tuberculosis tolerance in critically ill patients: a retrospective study. 38
30717702 2019
42
Recent Innovations in Diagnosis and Treatment of Pediatric Tuberculosis. 38
30767077 2019
43
Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis. 38
30683238 2019
44
Tuberculosis in Poland in 2017 38
31385679 2019
45
Ileal Tuberculosis Causing Hypercalcemia and Renal Failure. 38
30814795 2019
46
[Multidrug-resistant extrapulmonary tuberculosis: about 7 cases]. 38
31312308 2019
47
Obstetrical and perinatal outcome in pregnant women with extrapulmonary tuberculosis. 38
30797275 2019
48
Nephrocalcinosis in a patient with extrapulmonary tuberculosis - A rare entity. 38
30911525 2019
49
Pulmonary Versus Extrapulmonary Tuberculosis Associated Factors: A Case-Case Study. 38
30992667 2019
50
Evaluation of cases of pediatric extrapulmonary tuberculosis: a single center experience. 38
31384143 2019
Sources

Variations for Extrapulmonary Tuberculosis

About this section
Sources

Expression for Extrapulmonary Tuberculosis

About this section
Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.
Sources

Pathways for Extrapulmonary Tuberculosis

About this section

Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.94 TLR2 SLC11A1 P2RX7 IL1B IL10RA IL10
2
PEDF Induced Signaling 64
Show member pathways
 13.6 TBP IL1B IL10RA IL10 IFNGR1 IFNG
3
TGF-Beta Pathway 64
Show member pathways
 13.45 IL1B IL10RA IL10 IFNGR1 IFNG CD4
4
Akt Signaling 64
Show member pathways
 13.32 TLR2 IL1B IL10RA IL10 CD4 CCL2
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.29 IL1B IL10RA IL10 IFNGR1 IFNG CD4
6
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.99 TLR2 P2RX7 IL1B IL10 IFNGR1 IFNG
7
Human cytomegalovirus infection 37
Show member pathways
 12.9 TLR2 IL1B IL10RA IFNGR1 CD4 CCL2
8
Allograft rejection 37 1
Show member pathways
 12.79 IL1B IL10RA IL10 IFNGR1 IFNG CD4
9
4-1BB Pathway 64
Show member pathways
 12.64 TBP IL1B IFNGR1 IFNG CD4
10
Immune response NFAT in immune response 22
Show member pathways
 12.57 IL10RA IL10 IFNGR1 IFNG CD4
11
Th17 cell differentiation 37
Show member pathways
 12.51 TLR2 IL1B IL10 IFNGR1 IFNG CD4
12
T cell receptor signaling pathway 37
Show member pathways
 12.5 IL1B IL10 IFNG CD4
13
NF-kappaB Signaling 4
12.5 TLR2 IL1B IL10 IFNG CCL2
14
Immune response IL-23 signaling pathway 22
Show member pathways
 12.49 IL1B IL10RA IL10 IFNG CD4 CCL2
15
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.34 IL10RA IL10 IFNGR1 IFNG
16
IL-17 Family Signaling Pathways 65
Show member pathways
 12.29 TLR2 IL1B IFNG CCL2
17
Bacterial infections in CF airways 22
Show member pathways
 12.14 TLR2 IL1B IFNGR1 IFNG
18
Colorectal Cancer Metastasis 64
12.09 TLR2 IFNGR1 IFNG
19
Toxoplasmosis 37
Show member pathways
 12.07 TLR2 IL1B IL10RA IL10 IFNGR1 IFNG
20
Fluid shear stress and atherosclerosis 37
12.02 IL1B IFNG CCL2
21
Osteoclast differentiation 37
11.98 IL1B IFNGR1 IFNG
22
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.97 TLR2 IL1B IFNG
23
Spinal Cord Injury 1
11.94 IL1B IFNG CCL2
24
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.92 IL10 IFNG CD4
25
Interleukin-4 and 13 signaling 66
11.91 IL1B IL10 CCL2
26
IL12-mediated signaling events 1
Show member pathways
 11.9 IL1B IFNG CD4
27
Tuberculosis 37
11.89 TLR2 IL1B IL10RA IL10 IFNGR1 IFNG
28
Amoebiasis 37
11.88 TLR2 IL1B IL10 IFNG
29
Jak-Stat Signaling Pathway (sino) 67
11.83 IL10RA IL10 IFNGR1 IFNG
30
Rheumatoid arthritis 37
11.83 TLR2 IL1B IFNG CCL2
31
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.81 IL1B IL10RA IL10 IFNGR1 IFNG CD4
32
Salmonella infection (KEGG) 37
11.76 IL1B IFNGR1 IFNG
33
Innate Lymphoid Cell Differentiation Pathways 65
11.75 IL1B IL10 IFNG CD4
34
Dendritic Cells Developmental Lineage Pathway 65
11.71 IL1B IL10 IFNG CD4
35
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.68 IL1B IL10 IFNG CCL2
36
Th2 Differentiation Pathway 65
11.48 IL10 IFNG CD4
37
Interleukin-10 signaling 66
11.45 IL1B IL10RA IL10 CCL2
38
MSP-RON Signaling 64
11.42 TLR2 IL1B IFNG CCL2
39
Type II interferon signaling (IFNG) 1
11.36 IL1B IFNGR1 IFNG
40
African trypanosomiasis 37
11.34 IL1B IL10 IFNG
41
IL-10 Pathway 64
11.33 IL1B IL10RA IL10
42
Th1 Differentiation Pathway 65
Show member pathways
 11.21 TLR2 IL1B IL10 IFNGR1 IFNG CD4
43
G-protein signaling_RhoB regulation pathway 22
11.18 TBP IL1B IL10 CCL2
44
Cytokines and Inflammatory Response 1
11.17 IL1B IL10 IFNG CD4
45
OX40 Pathway 64
11.12 IL10 IFNG
46
IL1 and megakaryocytes in obesity 1
11.07 TLR2 IL1B IFNG CCL2
47
Malaria 37
11.04 TLR2 IL1B IL10 IFNG CCL2
48
LDL Oxidation in Atherogenesis 64
10.89 IL1B CCL2
Sources

GO Terms for Extrapulmonary Tuberculosis

About this section

Cellular components related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.1 TLR2 SLC11A1 PCDH15 P2RX7 IFNGR1 CD4

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.85 P2RX7 IFNG CD4 CCL2
2 positive regulation of gene expression GO:0010628 9.85 TLR2 SLC11A1 P2RX7 IL1B IFNG
3 response to bacterium GO:0009617 9.78 SLC11A1 P2RX7 CCL2
4 positive regulation of protein phosphorylation GO:0001934 9.78 P2RX7 IL1B IFNG CD4
5 response to drug GO:0042493 9.74 P2RX7 IL10 ADA
6 cellular response to lipopolysaccharide GO:0071222 9.73 IL1B IL10 HAMP CCL2
7 inflammatory response GO:0006954 9.73 TLR2 SLC11A1 P2RX7 IL1B IL10 CCL2
8 cellular response to organic cyclic compound GO:0071407 9.7 P2RX7 IL1B CCL2
9 positive regulation of interleukin-6 production GO:0032755 9.67 TLR2 P2RX7 IL1B
10 positive regulation of interleukin-12 production GO:0032735 9.64 TLR2 IFNG
11 defense response to protozoan GO:0042832 9.63 SLC11A1 IL10
12 response to ATP GO:0033198 9.63 P2RX7 IL1B
13 cytokine-mediated signaling pathway GO:0019221 9.63 IL1B IL10RA IL10 IFNGR1 CD4 CCL2
14 positive regulation of calcium-mediated signaling GO:0050850 9.62 CD4 ADA
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B IFNG
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B IL10
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.6 TLR2 CCL2
18 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.59 IFNGR1 IFNG
19 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.58 IL1B CD4
20 positive regulation of calcium ion transport into cytosol GO:0010524 9.58 P2RX7 CD4
21 response to molecule of bacterial origin GO:0002237 9.56 TLR2 IL10
22 multicellular organismal iron ion homeostasis GO:0060586 9.54 SLC11A1 HAMP
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 TLR2 IL1B CCL2
24 positive regulation of prostaglandin secretion GO:0032308 9.51 P2RX7 IL1B
25 positive regulation of T cell activation GO:0050870 9.5 CD4 CCL2 ADA
26 response to lipopolysaccharide GO:0032496 9.43 TLR2 SLC11A1 P2RX7 IL1B IL10RA IL10
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B IFNG
28 response to vitamin D GO:0033280 9.34 CD4
29 immune response GO:0006955 9.23 TLR2 SLC11A1 IL1B IL10 IFNG HAMP

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.26 TLR2 P2RX7 IL10RA CD4
2 cytokine activity GO:0005125 8.92 IL1B IL10 IFNG CCL2
Sources

Sources for Extrapulmonary Tuberculosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....