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EPTB
MCID: EXT033
MIFTS: 46

Extrapulmonary Tuberculosis (EPTB)

Categories: Immune diseases, Infectious diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Extrapulmonary Tuberculosis

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MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 12 54 15
Tuberculosis, Extrapulmonary 71
Eptb 47

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050598
UMLS 71 C0679362
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Summaries for Extrapulmonary Tuberculosis

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Disease Ontology : 12 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary : Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to tuberculous peritonitis and lymph node tuberculosis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 74 Extrapulmonary tuberculosis is tuberculosis (TB) within a location in the body other than the lungs.... more...

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Related Diseases for Extrapulmonary Tuberculosis

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Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 470)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 33.3 IFNG CRP ADA
2 lymph node tuberculosis 33.0 SP110 IFNG CD4
3 skeletal tuberculosis 33.0 IFNG CRP
4 pleural tuberculosis 32.9 IFNG CD4 CCL2 ADA
5 miliary tuberculosis 32.6 IFNG CRP CD4 ADA
6 abdominal tuberculosis 32.6 IFNG CRP CD4 ADA
7 pericardial tuberculosis 32.6 IFNG CRP CD4 ADA
8 tuberculous meningitis 31.5 TLR2 CCL2 ADA
9 allergic hypersensitivity disease 30.7 TLR2 IL10 IFNG CD4
10 cervical adenitis 30.6 IL1RN IL1B CRP
11 pericarditis 30.5 IL1RN IL1B IFNG CRP ADA
12 spondylitis 30.5 IL1RN IL10 IFNG CRP
13 intestinal tuberculosis 30.5 IFNG CRP CD4
14 post-transplant lymphoproliferative disease 30.4 SLC11A1 IL10RA IL10
15 osteomyelitis 30.3 TLR2 IL1RN IL1B IL10 IFNGR1 IFNG
16 multidrug-resistant tuberculosis 30.3 VDR SLC11A1 IL10 IFNG CD4
17 toxoplasmosis 30.3 TLR2 IL1B IL10 IFNG
18 prostatitis 30.3 VDR IL1B IL10
19 chorioretinitis 30.3 IL10 IFNG CD4
20 choroiditis 30.3 IL10 IFNG CD4
21 carpal tunnel syndrome 30.3 IL1RN IL1B CCL2
22 pleurisy 30.2 TLR2 IL1RN IFNG CRP CCL2 ADA
23 peritonitis 30.2 TLR2 IL1B IL10 IFNG CRP CCL2
24 pericardial effusion 30.1 CRP CD4 ADA
25 human immunodeficiency virus type 1 30.0 IL10 IFNG CD4 CCL2 ADA
26 acquired immunodeficiency syndrome 30.0 IL1B IL10 IFNG CRP CD4 ADA
27 meningoencephalitis 29.9 IL10 CRP CD4
28 chronic meningitis 29.9 IL1RN CRP CD4
29 pulmonary tuberculosis 29.9 VDR TLR2 SLC11A1 P2RX7 MBL2 IL10
30 lymph node disease 29.9 TLR2 IL10 IFNG CRP CD4
31 gastrointestinal tuberculosis 29.8 IFNG CRP CD4 ADA
32 keratitis, hereditary 29.8 TLR2 IL1B IL10 CXCL9 CD4
33 viral encephalitis 29.8 IL1B IL10 CXCL9 CD4 CCL2
34 lymphadenitis 29.8 VDR SLC11A1 IL1B IL10 IFNGR1 IFNG
35 otitis media 29.8 TLR2 MBL2 IL1B IL10 IFNG CRP
36 panuveitis 29.7 IL1RN IL10 CRP CD4
37 brucellosis 29.7 SLC11A1 IL1RN IL10 IFNG HAMP CRP
38 immune deficiency disease 29.7 VDR MBL2 IL10 IFNGR1 IFNG CD4
39 mycobacterium tuberculosis 1 29.6 VDR TLR2 SLC11A1 P2RX7 MBL2 IL10
40 pleural disease 29.6 IL1B IFNG CRP CD4 ADA
41 toxic shock syndrome 29.6 TLR2 IL1RN IL1B IL10 IFNG CRP
42 pyelonephritis 29.5 MBL2 IL1B IL10 IFNG CRP CCL2
43 chronic kidney disease 29.5 VDR IL10 HAMP CRP CCL2
44 meningitis 29.5 TLR2 MBL2 IL1B IL10 IFNG CRP
45 leprosy 3 29.4 VDR TLR2 SLC11A1 IL1B IL10 IFNG
46 arthritis 29.4 TLR2 SLC11A1 IL1RN IL1B IL10 IFNG
47 thrombocytopenia 29.3 TLR2 IL1RN IL1B IL10 IFNG CRP
48 lung disease 29.2 TLR2 SLC11A1 MBL2 IL1B IL10 IFNGR1
49 diabetes mellitus 28.6 VDR TLR2 IL1RN IL1B IL10 IFNG
50 crohn's disease 28.6 TLR2 SLC11A1 IL1B IL10RA IL10 IFNG

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis
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Symptoms & Phenotypes for Extrapulmonary Tuberculosis

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MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ADA CRP IFNG IFNGR1 IL10 IL1B
2 hematopoietic system MP:0005397 10.17 ADA CD4 IFNG IFNGR1 IL10 IL10RA
3 cellular MP:0005384 10.14 ADA CD4 IFNG IFNGR1 IL10 IL10RA
4 homeostasis/metabolism MP:0005376 10.1 ADA CD4 CRP IFNG IFNGR1 IL10
5 immune system MP:0005387 10.06 ADA CCL2 CD4 CRP IFNG IFNGR1
6 digestive/alimentary MP:0005381 10.02 ADA CD4 IFNG IFNGR1 IL10 IL10RA
7 integument MP:0010771 9.61 CD4 IFNG IFNGR1 IL10 IL1B IL1RN
8 skeleton MP:0005390 9.36 ADA IFNG IFNGR1 IL10 IL1B IL1RN
Sources

Drugs & Therapeutics for Extrapulmonary Tuberculosis

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Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Antitubercular Agents Phase 3
8 Vaccines Phase 3
9 Antiemetics Phase 3
10 Methylprednisolone Acetate Phase 3
11 Gastrointestinal Agents Phase 3
12 Hormone Antagonists Phase 3
13 Neuroprotective Agents Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Autonomic Agents Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 glucocorticoids Phase 3
18 Protective Agents Phase 3
19 Immunologic Factors Phase 3
20 Hormones Phase 3
21
Lithium carbonate Approved 554-13-2
22
Heparin Approved, Investigational 9005-49-6 772 46507594
23 Anti-Bacterial Agents
24 calcium heparin
25 Fluorodeoxyglucose F18
26 Antiviral Agents
27 Antimetabolites
28 Deoxyglucose
29 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centric Study on Treatment of Abdominal Tuberculosis (Intestinal or Peritoneal): A Randomized Controlled Trial to Compare the 6 Months of Cat I Treatment With 9 Months of Cat I Treatment (Extension for 3 Months) in Abdominal Tuberculosis Under the Revised National Tuberculosis Control Program Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
2 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
3 Paradoxical Reactions During Anti-mycobacterial Treatment of Extrapulmonary Tuberculosis in Non Immuno-compromized Patients : Clinical, Radiological et Immunological Completed NCT01252992
4 Evaluation of Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196
5 Evaluation of Efficacy of Thrice Weekly DOTS Regimen in Tubercular Pleural Effusion at 6 Months Completed NCT01560078
6 FDG-PET/CT: a Tool in Diagnosis and Treatment Response Monitoring of Extrapulmonary Tuberculosis in HIV Patients Completed NCT02822014
7 Diagnosis of Tuberculous Meningitis by a Secretory Antigenic Target 6 (ESAT-6) in CSF Completed NCT01371916
8 Evaluation of TB-antigen Responsive T Cell Markers in Diagnosis of Tuberculosis and Extrapulmonary Tuberculosis Recruiting NCT04148053
9 Detection of Circulating Mycobacterium Tuberculosis Antigen Peptides for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Recruiting NCT03271567
10 Point-of-care Strategies to Improve Tuberculosis Care Among Severely Immunosuppressed HIV-infected Patients Recruiting NCT04122404

Search NIH Clinical Center for Extrapulmonary Tuberculosis

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Genetic Tests for Extrapulmonary Tuberculosis

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Anatomical Context for Extrapulmonary Tuberculosis

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MalaCards organs/tissues related to Extrapulmonary Tuberculosis:

40
Lung, Bone, Testes, Liver, Lymph Node, T Cells, Breast
Sources

Publications for Extrapulmonary Tuberculosis

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Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 1928)
# Title Authors PMID Year
1
[Adenosine deaminase in the complex diagnosis of different forms of extrapulmonary tuberculosis]. 54 61
17195584 2006
2
Extrapulmonary tuberculosis: an overview. 54 61
16300038 2005
3
[Cardiac tamponade with paroxysmal atrial flutter controlled by antituberculous therapy]. 54 61
14999926 2004
4
Diagnosing peritoneal tuberculosis. 61
32033999 2020
5
Intensified adjunctive corticosteroid therapy for CNS tuberculomas. 61
31900872 2020
6
[The Diagnostic Value of TSPOT.TB in Children with Tuberculosis]. 61
31950796 2020
7
A Review of the Diagnostic Use of Fine-needle Aspiration Cytology for Tuberculosis Epididymo-orchitis: To Do or Not to Do. 61
32038890 2020
8
Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis. 61
31778149 2020
9
Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review and patient-level pooled meta-analysis. 61
31958400 2020
10
Identification of disguised extrapulmonary tuberculosis. 61
31987746 2020
11
Immune reconstitution inflammatory syndrome in the lung in non-human immunodeficiency virus patients. 61
31791908 2020
12
Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia. 61
31898556 2020
13
Clinical Profi le of Patients with Extrapulmonary Tuberculosis. 61
31979872 2020
14
Comparison of CapitalBioâ„¢ Mycobacterium nucleic acid detection test and Xpert MTB/RIF assay for rapid diagnosis of extrapulmonary tuberculosis. 61
31751598 2020
15
Xpert MTB/RIF assay for diagnosis of extrapulmonary tuberculosis in children: a systematic review and meta-analysis. 61
31906996 2020
16
In reply to MS 22060 - Diagnosis of extrapulmonary tuberculosis and avoiding anchoring bias. 61
31982221 2020
17
Limited sampling strategy for predicting isoniazid exposure in patients with extrapulmonary tuberculosis. 61
31833581 2019
18
Low diagnostic accuracy of Xpert MTB/RIF assay for extrapulmonary tuberculosis: A multicenter surveillance. 61
31811239 2019
19
Evaluation of GeneXpert MTB/RIF system performances in the diagnosis of extrapulmonary tuberculosis. 61
31856744 2019
20
Suspected reactivation of extrapulmonary tuberculosis focus after non-medical abuse of anabolic androgenic steroids: a case report. 61
31874100 2019
21
Simple Processing of Formalin-Fixed Paraffin-Embedded Tissue for Accurate Testing with the Xpert MTB/RIF assay. 61
31852763 2019
22
PET/CT features of Extrapulmonary Tuberculosis at first clinical presentation - a cross-sectional observational 18F-FDG imaging study across six countries. 61
31831584 2019
23
Contribution of Real-Time Xpert MTB/RIF Testing to Establishing Early Diagnosis of Pediatric Extrapulmonary Tuberculosis in a Nonendemic Setting: A Case Series. 61
31651811 2019
24
The epidemiology of 32 selected communicable diseases in Iraq, 2004-2016. 61
31560993 2019
25
Adjacent Level Tuberculous Spondylodiscitis Leading to Proximal Junctional Kyphosis: Rare and Unusual Presentation. 61
31715405 2019
26
The rapid molecular test Xpert MTB/RIF ultra: towards improved tuberculosis diagnosis and rifampicin resistance detection. 61
30928564 2019
27
Extrapulmonary Tuberculosis: Pathophysiology and Imaging Findings. 61
31697616 2019
28
Tuberculosis: Diagnostic Challenges in Rural Africa. 61
31771490 2019
29
[CME: Extrapulmonary Tuberculosis]. 61
31771497 2019
30
Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children. 61
31299414 2019
31
Changes in inflammatory protein and lipid mediator profiles persist after antitubercular treatment of pulmonary and extrapulmonary tuberculosis: A prospective cohort study. 61
31226436 2019
32
[Ultrasound Course in Ifakara (Tanzania) with Case Studies]. 61
31771486 2019
33
Current study of the detection and treatment targets of spinal tuberculosis. 61
31577205 2019
34
Association between Fine-needle Aspiration Cytological Features and CD4 Level in Human Immunodeficiency Virus-Associated Tuberculous Lymphadenitis Patients Admitted to Haji Adam Malik Hospital in 2017. 61
32002078 2019
35
Evaluation of the Yield of Histopathology in the Diagnosis of Lymph Node Tuberculosis in Morocco, 2017: Cross-Sectional Study. 61
31599732 2019
36
Survival analysis of patients with tuberculosis in Erbil, Iraqi Kurdistan region. 61
31638949 2019
37
Field performance of the Abbott RealTime MTB assay for the diagnosis of extrapulmonary tuberculosis in a low-prevalence setting. 61
31668859 2019
38
Extrapulmonary Tuberculosis in Denmark From 2009 to 2014; Characteristics and Predictors for Treatment Outcome. 61
31660351 2019
39
Tuberculosis of the elbow: A rare form of presentation of extrapulmonary tuberculosis. 61
30241670 2019
40
Breast Abcess and Tuberculosis and its Diagnostic Challenges: A Two-Year Prospective Study in Karachi, Pakistan. 61
31788369 2019
41
Severe disseminated tuberculosis in HIV-negative refugees. 61
31182290 2019
42
Gastric tuberculosis presenting as non healing ulcer: A case report. 61
31813440 2019
43
Thymic Tuberculosis Shown on FDG PET/CT Despite Coexisting Pulmonary Tuberculosis With No Increased FDG Activity. 61
31283603 2019
44
Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals. 61
31565799 2019
45
Clinical Profile and Treatment Response of Patients with Ocular Inflammation due to Presumed Ocular Tuberculosis: A Retrospective Study 61
31486605 2019
46
Primary Laryngeal Tuberculosis: Our Experiences at a Tertiary Care Teaching Hospital in Eastern India. 61
29773323 2019
47
Paradoxical reactions in ocular tuberculosis. 61
31493128 2019
48
Culture positivity of smear negative pulmonary and extrapulmonary tuberculosis- A study from North Kerala, India. 61
31681664 2019
49
Platelet phagocytosis in the bone marrow causing thrombocytopenia in extrapulmonary tuberculosis. 61
31570364 2019
50
Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low- and middle-income countries: a multicohort study. 61
31507083 2019
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Variations for Extrapulmonary Tuberculosis

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Expression for Extrapulmonary Tuberculosis

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Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.
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Pathways for Extrapulmonary Tuberculosis

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Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.96 TLR2 TIRAP SLC11A1 P2RX7 MBL2 IL1RN
2
PEDF Induced Signaling 63
Show member pathways
 13.66 IL1RN IL1B IL10RA IL10 IFNGR1 IFNG
3
Akt Signaling 63
Show member pathways
 13.38 TLR2 TIRAP IL1B IL10RA IL10 CXCL9
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.32 IL1RN IL1B IL10RA IL10 IFNGR1 IFNG
5
Human cytomegalovirus infection 36
Show member pathways
 12.91 TLR2 IL1B IL10RA IFNGR1 CD4 CCL2
6
Allograft rejection 1 36
Show member pathways
 12.83 IL1B IL10 IFNG CXCL9 CD4
7
Measles 36
Show member pathways
 12.79 TLR2 IL1B IFNGR1 IFNG CCL2
8
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 12.79 TLR2 TIRAP P2RX7 MBL2 IL1B IL10
9
Herpes simplex virus 1 infection 36
12.77 TLR2 IL1B IFNGR1 IFNG CCL2
10
Immune response NFAT in immune response 22
Show member pathways
 12.61 IL10RA IL10 IFNGR1 IFNG CD4
11
Th17 cell differentiation 36
Show member pathways
 12.58 TLR2 IL1B IL10 IFNGR1 IFNG CD4
12
NF-kappaB Signaling 4
12.54 TLR2 IL1RN IL1B IL10 IFNG CCL2
13
T cell receptor signaling pathway 36
Show member pathways
 12.54 TLR2 TIRAP IL1B IL10 IFNGR1 IFNG
14
Immune response IL-23 signaling pathway 22
Show member pathways
 12.51 IL1B IL10RA IL10 IFNG CXCL9 CD4
15
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.32 IL10RA IL10 IFNGR1 IFNG
16
IL-17 Family Signaling Pathways 64
Show member pathways
 12.31 TLR2 IL1B IFNG CCL2
17
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.3 IL10RA IL10 CXCL9 CCL2
18
Folate Metabolism 1
Show member pathways
 12.3 IL1B IFNG CRP CCL2
19
Toll Comparative Pathway 63
Show member pathways
 12.29 TIRAP IL1B IFNGR1 IFNG
20
Toxoplasmosis 36
Show member pathways
 12.23 TLR2 IL1B IL10RA IL10 IFNGR1 IFNG
21
IL-1 Family Signaling Pathways 64
Show member pathways
 12.2 TLR2 TIRAP IL1RN IL1B
22
Bacterial infections in CF airways 22
Show member pathways
 12.17 TLR2 TIRAP IL1B IFNGR1 IFNG
23
Th1 Differentiation Pathway 64
Show member pathways
 11.96 TLR2 IL1B IL10 IFNGR1 IFNG CD4
24
Amoebiasis 36
11.91 TLR2 IL1B IL10 IFNG
25
Jak-Stat Signaling Pathway (sino) 66
11.87 IL10RA IL10 IFNGR1 IFNG
26
Rheumatoid arthritis 36
11.86 TLR2 IL1B IFNG CCL2
27
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.81 IL1B IFNGR1 IFNG
28
Innate Lymphoid Cell Differentiation Pathways 64
11.79 IL1B IL10 IFNG CD4
29
Salmonella infection (KEGG) 36
11.76 IL1B IFNGR1 IFNG
30
Dendritic Cells Developmental Lineage Pathway 64
11.75 IL1B IL10 IFNG CD4
31
Pertussis 36
11.73 TIRAP IL1B IL10
32
MSP-RON Signaling 63
11.52 TLR2 IL1B IFNG CCL2
33
Th2 Differentiation Pathway 64
11.49 IL10 IFNG CD4
34
Tuberculosis 36
11.48 VDR TLR2 TIRAP IL1B IL10RA IL10
35
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.47 VDR IL1B IFNG
36
Malaria 36
11.42 TLR2 IL1B IL10 IFNG CCL2
37
Type II interferon signaling (IFNG) 1
11.38 IL1B IFNGR1 IFNG CXCL9
38
African trypanosomiasis 36
11.36 IL1B IL10 IFNG
39
Interleukin-10 signaling 65
11.34 IL1RN IL1B IL10RA IL10 CCL2
40
IL-10 Pathway 63
11.33 IL1B IL10RA IL10
41
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.28 IL1RN IL1B IL10 IFNG CXCL9 CCL2
42
Cytokines and Inflammatory Response 1
11.26 IL1B IL10 IFNG CD4
43
IL1 and megakaryocytes in obesity 1
11.1 TLR2 IL1B IFNG CCL2
Sources

GO Terms for Extrapulmonary Tuberculosis

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Cellular components related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.7 VDR SLC11A1 P2RX7 HAMP CXCL9 CD4
2 extracellular region GO:0005576 9.65 PCDH15 MBL2 IL1RN IL1B IL10 IFNG
3 extracellular space GO:0005615 9.32 MBL2 IL1RN IL1B IL10 IFNG HAMP

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.2 VDR TLR2 TIRAP IL1RN IL1B IL10
2 defense response to bacterium GO:0042742 9.98 SLC11A1 MBL2 IL10 HAMP
3 cell surface receptor signaling pathway GO:0007166 9.95 TIRAP P2RX7 IFNG CD4 CCL2
4 positive regulation of protein phosphorylation GO:0001934 9.92 P2RX7 IL1B IFNG CD4
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TIRAP IL1RN IL1B CD4
6 positive regulation of gene expression GO:0010628 9.92 VDR TLR2 SLC11A1 P2RX7 IL1B IFNGR1
7 cytokine-mediated signaling pathway GO:0019221 9.91 IL1RN IL1B IL10RA IL10 IFNGR1 CD4
8 response to bacterium GO:0009617 9.88 SLC11A1 P2RX7 CXCL9 CCL2
9 positive regulation of JNK cascade GO:0046330 9.85 TIRAP IL1RN IL1B
10 neutrophil chemotaxis GO:0030593 9.83 IL1RN IL1B CXCL9 CCL2
11 cellular response to organic cyclic compound GO:0071407 9.81 P2RX7 IL1B CCL2
12 defense response to Gram-positive bacterium GO:0050830 9.8 TLR2 TIRAP P2RX7 MBL2 CRP
13 cellular response to lipopolysaccharide GO:0071222 9.8 VDR IL1RN IL1B IL10 HAMP CXCL9
14 acute-phase response GO:0006953 9.78 MBL2 HAMP CRP
15 positive regulation of interleukin-6 production GO:0032755 9.78 TLR2 P2RX7 IL1RN IL1B
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TLR2 IL1B CCL2
17 microglial cell activation GO:0001774 9.76 TLR2 IFNGR1 IFNG
18 positive regulation of interleukin-8 production GO:0032757 9.74 TLR2 TIRAP IL1B
19 positive regulation of interleukin-12 production GO:0032735 9.73 TLR2 TIRAP IFNG
20 positive regulation of phagocytosis GO:0050766 9.73 SLC11A1 MBL2 IL1B IFNG
21 positive regulation of T cell activation GO:0050870 9.71 CD4 CCL2 ADA
22 response to lipopolysaccharide GO:0032496 9.7 TLR2 TIRAP SLC11A1 P2RX7 IL1B IL10RA
23 astrocyte activation GO:0048143 9.69 IL1B IFNGR1 IFNG
24 response to molecule of bacterial origin GO:0002237 9.67 TLR2 IL10
25 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B IFNG
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR2 IFNG CCL2
27 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.66 IL1RN IL10
28 negative regulation of amyloid-beta clearance GO:1900222 9.66 IFNGR1 IFNG
29 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TIRAP
30 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IFNG
31 multicellular organismal iron ion homeostasis GO:0060586 9.65 SLC11A1 HAMP
32 immune response GO:0006955 9.65 TLR2 SLC11A1 IL1RN IL1B IL10 IFNG
33 opsonization GO:0008228 9.64 MBL2 CRP
34 positive regulation of NMDA glutamate receptor activity GO:1904783 9.63 IFNG CCL2
35 positive regulation of prostaglandin secretion GO:0032308 9.63 P2RX7 IL1B
36 cellular response to bacterial lipopeptide GO:0071221 9.61 TLR2 TIRAP
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 IL1B IFNG
38 inflammatory response GO:0006954 9.32 TLR2 TIRAP SLC11A1 P2RX7 IL1RN IL1B

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.35 VDR TLR2 P2RX7 IL10RA CD4
2 cytokine activity GO:0005125 9.1 IL1RN IL1B IL10 IFNG CXCL9 CCL2
Sources

Sources for Extrapulmonary Tuberculosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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