EPTB
MCID: EXT033
MIFTS: 49

Extrapulmonary Tuberculosis (EPTB)

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Extrapulmonary Tuberculosis

MalaCards integrated aliases for Extrapulmonary Tuberculosis:

Name: Extrapulmonary Tuberculosis 12 56 15
Tuberculosis, Extrapulmonary 74
Eptb 49

Classifications:



External Ids:

Disease Ontology 12 DOID:0050598
UMLS 74 C0679362

Summaries for Extrapulmonary Tuberculosis

Disease Ontology : 12 A tuberculosis that occurs at body sites other than the lung.

MalaCards based summary : Extrapulmonary Tuberculosis, also known as tuberculosis, extrapulmonary, is related to miliary tuberculosis and tuberculous peritonitis. An important gene associated with Extrapulmonary Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Rifapentine and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 77 Extrapulmonary tuberculosis is tuberculosis (TB) within another location in the body than the lungs.... more...

Related Diseases for Extrapulmonary Tuberculosis

Diseases related to Extrapulmonary Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 miliary tuberculosis 32.3 ADA IFNG
2 tuberculous peritonitis 32.3 ADA IFNG TBP
3 abdominal tuberculosis 32.2 ADA TBP
4 pericardial tuberculosis 31.9 ADA IFNG IL10 TBP
5 pleural tuberculosis 31.8 ADA CCL2 IFNG TBP
6 brucellosis 30.5 IFNG IL10 SLC11A1
7 uveitis 30.4 CCL2 IFNG IL10
8 acquired immunodeficiency syndrome 30.3 IFNG IL10 IL1B
9 osteomyelitis 30.1 IFNG IL10 IL1B
10 arthritis 30.1 CCL2 IFNG IL10 IL1B
11 tuberculous meningitis 30.1 ADA CCL2 TLR2
12 human immunodeficiency virus type 1 29.8 ADA CCL2 IFNG IL10
13 otitis media 29.6 IL10 IL1B MBL2 TLR2
14 rheumatoid arthritis 29.3 CCL2 IFNG IL10 IL1B SLC11A1 TLR2
15 mycobacterium tuberculosis 1 29.3 ADA IFNG IL10 MBL2 P2RX7 SLC11A1
16 systemic lupus erythematosus 29.0 CCL2 IFNG IL10 IL1B MBL2 TLR2
17 meningitis 28.9 ADA CCL2 IFNG IL10 IL1B MBL2
18 pulmonary tuberculosis 28.6 ADA IFNG IL10 MBL2 P2RX7 SLC11A1
19 central nervous system tuberculosis 11.2
20 skeletal tuberculosis 11.2
21 urogenital tuberculosis 11.2
22 lymph node tuberculosis 11.2
23 cephalosporin allergy 10.4 IFNG IL10
24 hyperlucent lung 10.4 IFNG IL10
25 sporotrichosis 10.4 IFNG IL10
26 nickel allergic contact dermatitis 10.4 IFNG IL10
27 staphylococcal toxic shock syndrome 10.4 IFNG IL1B
28 palladium allergic contact dermatitis 10.3 CCL2 IL10
29 baylisascariasis 10.3 IFNG IL10
30 neurosyphilis 10.3 IL10 TLR2
31 periodontitis, chronic 10.3 IL1B TLR2
32 chronic graft versus host disease 10.3 IFNG IL10
33 clonorchiasis 10.3 IFNG IL10
34 purulent labyrinthitis 10.3 CCL2 IL1B
35 tuberculoid leprosy 10.3 IFNG IL10
36 funisitis 10.3 IL10 IL1B
37 retinitis pigmentosa 73 10.3 CCL2 IL1B
38 mycoplasma pneumoniae pneumonia 10.3 IFNG IL10 TLR2
39 haemophilus influenzae 10.3 IL1B TLR2
40 fascioliasis 10.3 IFNG IL10 IL1B
41 paracoccidioidomycosis 10.3 IFNG IL10 TLR2
42 opportunistic mycosis 10.3 IFNG IL10 TLR2
43 crohn's colitis 10.3 IFNG IL1B
44 eales disease 10.3 IFNG IL10 IL1B
45 aseptic meningitis 10.3 IFNG IL10 IL1B
46 echinococcosis 10.3 IFNG IL10 TLR2
47 melioidosis 10.3 IFNG IL10 TLR2
48 fungal meningitis 10.2 CCL2 IFNG IL10
49 myositis fibrosa 10.2 IFNG TLR2
50 filariasis 10.2 IFNG IL10 TLR2

Graphical network of the top 20 diseases related to Extrapulmonary Tuberculosis:



Diseases related to Extrapulmonary Tuberculosis

Symptoms & Phenotypes for Extrapulmonary Tuberculosis

MGI Mouse Phenotypes related to Extrapulmonary Tuberculosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 ADA IFNG IL10 IL1B P2RX7 TBP
2 growth/size/body region MP:0005378 10.02 ADA IFNG IL10 IL1B P2RX7 PCDH15
3 hematopoietic system MP:0005397 10.02 ADA IFNG IL10 IL1B MBL2 P2RX7
4 homeostasis/metabolism MP:0005376 9.96 ADA IFNG IL10 IL1B MBL2 P2RX7
5 immune system MP:0005387 9.9 ADA CCL2 IFNG IL10 IL1B MBL2
6 digestive/alimentary MP:0005381 9.88 ADA IFNG IL10 SLC11A1 TLR2 VDR
7 muscle MP:0005369 9.43 ADA IFNG IL10 PCDH15 TLR2 VDR
8 skeleton MP:0005390 9.23 ADA IFNG IL10 IL1B P2RX7 TBP

Drugs & Therapeutics for Extrapulmonary Tuberculosis

Drugs for Extrapulmonary Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
2
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
3
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
4 Anti-Bacterial Agents Phase 3
5 Antimetabolites Phase 3,Not Applicable
6 Anti-Infective Agents Phase 3,Not Applicable
7 Hypolipidemic Agents Phase 3
8 Nucleic Acid Synthesis Inhibitors Phase 3
9 Antibiotics, Antitubercular Phase 3
10 Cytochrome P-450 CYP3A Inducers Phase 3
11 Antitubercular Agents Phase 3
12 Lipid Regulating Agents Phase 3
13
Lithium carbonate Approved 554-13-2
14
Heparin Approved, Investigational 9005-49-6 772 46507594
15
Rilpivirine Approved 500287-72-9
16 calcium heparin
17 Fluorodeoxyglucose F18 Not Applicable
18 Antiviral Agents Not Applicable
19 Deoxyglucose Not Applicable
20 Anti-HIV Agents
21 Reverse Transcriptase Inhibitors
22 Anti-Retroviral Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Tuberculosis Prevention for HIV Infected Adults Completed NCT00057122 Phase 3 Isoniazid;Rifapentine;Rifampin
2 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
3 Paradoxical Reactions in Non Immuno-compromized Patients With Extrapulmonary Tuberculosis Unknown status NCT01252992
4 Role of Genexpert in Extra Pulmonary Tuberculosis Not yet recruiting NCT03173261 Not Applicable
5 Positron Emission Tomography in Extrapulmonary Tuberculosis Completed NCT01613196 Not Applicable
6 Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients Recruiting NCT03271567
7 PET/CT in Extrapulmonary TB in HIV Patients: a Clinical Trial Completed NCT02822014 Not Applicable
8 Intervention in the Management of Post-high Tuberculosis Hospital Through Educational Strategy and Oversight Distance Completed NCT02558842 Not Applicable
9 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
10 Bronchial Washings in Sputum Scarce Cases of Pulmonary Tuberculosis Not yet recruiting NCT03732014
11 Effect of Xpert MTB/RIF on Patient Outcomes Active, not recruiting NCT02729532
12 A Study on the Safety and Effectiveness of Rilpivirine Hydrochloride (Edurant) Among Adult Filipino Patients With Human Immunodeficiency Virus Type-I Infection Withdrawn NCT01692470 No intervention

Search NIH Clinical Center for Extrapulmonary Tuberculosis

Genetic Tests for Extrapulmonary Tuberculosis

Anatomical Context for Extrapulmonary Tuberculosis

MalaCards organs/tissues related to Extrapulmonary Tuberculosis:

42
Bone, Testes, T Cells, Kidney, Lymph Node, Bone Marrow, Whole Blood

Publications for Extrapulmonary Tuberculosis

Articles related to Extrapulmonary Tuberculosis:

(show top 50) (show all 443)
# Title Authors Year
1
Pachymeningitis with optic neuropathy associated with extrapulmonary tuberculosis and secondary antiphospholipid syndrome. ( 30685445 )
2019
2
Nephrocalcinosis in a patient with extrapulmonary tuberculosis - A rare entity. ( 30911525 )
2019
3
Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran. ( 30513341 )
2019
4
Extrapulmonary Tuberculosis Presenting With Double Vision in a Resource-Limited Tropical Setting. ( 30652664 )
2019
5
Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis. ( 30738907 )
2019
6
Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008-2017. ( 30789144 )
2019
7
Obstetrical and perinatal outcome in pregnant women with extrapulmonary tuberculosis. ( 30797275 )
2019
8
A trial sequential meta-analysis of IFN-γ +874 A>T (rs2430561) gene polymorphism and extrapulmonary tuberculosis risk. ( 30825502 )
2019
9
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting. ( 30846768 )
2019
10
A Case of Extrapulmonary Tuberculosis Two-Ways. ( 30854165 )
2019
11
Patient Health Seeking and Diagnostic Delay in Extrapulmonary Tuberculosis: A Hospital Based Study from Central India. ( 30854235 )
2019
12
Fever with pancytopenia: unusual presentation of extrapulmonary tuberculosis: a case report. ( 29506574 )
2018
13
The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis. ( 29950533 )
2018
14
The Use of TB-Specific Antigen/Phytohemagglutinin Ratio for Diagnosis and Treatment Monitoring of Extrapulmonary Tuberculosis. ( 29868010 )
2018
15
Prevalence and risk factors of drug-resistant extrapulmonary tuberculosis. ( 29424965 )
2018
16
Performance of the IS6110-TaqManAr assay in the diagnosis of extrapulmonary tuberculosis from different biological samples. ( 29972564 )
2018
17
Diagnostic accuracy of the loop-mediated isothermal amplification assay for extrapulmonary tuberculosis: A meta-analysis. ( 29944682 )
2018
18
MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. ( 29742144 )
2018
19
Positive outcome of pulmonary tuberculosis associated with extraordinary extensive extrapulmonary tuberculosis in an immunocompetent adult. ( 29900898 )
2018
20
Response to the review article "Imaging in extrapulmonary tuberculosis" from the International Atomic Energy Agency Extra-pulmonary TB Consortium; March 2017, volume 56, pages 237-247. ( 29155088 )
2018
21
A Hospital-Based Cross-sectional Study on Clinico-demographic Characteristic of Extrapulmonary Tuberculosis Cases Coming to a Tertiary Hospital of Bihar. ( 29899614 )
2018
22
Eosinophilia, a marker of asymptomatic<i>Strongyloides</i>infection, in a young patient with extrapulmonary tuberculosis. ( 29301814 )
2018
23
Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients. ( 29141727 )
2018
24
Evaluation of the Xpert MTB/RIF assay for diagnosis of smear-negative pulmonary and extrapulmonary tuberculosis in Madagascar. ( 29408360 )
2018
25
Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis. ( 29872046 )
2018
26
Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics. ( 30631629 )
2018
27
Specific cholecystitis: An unusual presentation of extrapulmonary tuberculosis. ( 30243911 )
2018
28
A Review of Extrapulmonary Tuberculosis. ( 29991098 )
2018
29
Prospective Serial FDG PET/CT During Treatment of Extrapulmonary Tuberculosis in HIV-Infected Patients: An Exploratory Study. ( 30015658 )
2018
30
Patterns of uveitis in patients with proven systemic (pulmonary and extrapulmonary) tuberculosis. ( 30022332 )
2018
31
Extrapulmonary Tuberculosis in Federation of Bosnia and Herzegovina. ( 30061808 )
2018
32
Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance. ( 30148542 )
2018
33
Delayed diagnosis of extrapulmonary tuberculosis presenting as fever of unknown origin in an intermediate-burden country. ( 30153813 )
2018
34
Extrapulmonary tuberculosis: atypical presentation in otorhinolaryngology. ( 30158260 )
2018
35
Assessment of Extrapulmonary Tuberculosis Using Gene Xpert MTB/RIF Assay and Fluorescent Microscopy and Its Risk Factors at Dessie Referral Hospital, Northeast Ethiopia. ( 30159328 )
2018
36
Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: A study from Zanzibar. ( 30188947 )
2018
37
Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India. ( 30197919 )
2018
38
Predictors for false-negative QuantiFERON-TB Gold assay results in patients with extrapulmonary tuberculosis. ( 30200884 )
2018
39
Tuberculosis of the elbow: A rare form of presentation of extrapulmonary tuberculosis. ( 30241670 )
2018
40
Diagnostic accuracy of Xpert MTB/RIF assay in extrapulmonary tuberculosis. ( 30429387 )
2018
41
Prevalence of extrapulmonary tuberculosis among people living with HIV/AIDS in sub-Saharan Africa: a systemic review and meta-analysis. ( 30464643 )
2018
42
Extrapulmonary tuberculosis: a debilitating and often neglected public health problem. ( 30573534 )
2018
43
Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a diagnostic evaluation study. ( 30583052 )
2018
44
Index-TB guidelines: Guidelines on extrapulmonary tuberculosis for India. ( 28862176 )
2017
45
Extrapulmonary Tuberculosis of Lymph Node Coexist with Diffuse Large B-cell Lymphoma: A Case Report. ( 29200700 )
2017
46
Detection of ofloxacin resistance by nitrate reductase assay in Mycobacterium tuberculosis isolates from extrapulmonary tuberculosis. ( 28303821 )
2017
47
Immune Reconstitution Inflammatory Syndrome Occurring in a Kidney Transplant Patient with Extrapulmonary Tuberculosis. ( 28367350 )
2017
48
Use of Digital Droplet PCR to Detect Mycobacterium tuberculosis DNA in Whole Blood-Derived DNA Samples from Patients with Pulmonary and Extrapulmonary Tuberculosis. ( 28848722 )
2017
49
Treatment outcome of extrapulmonary tuberculosis under Revised National Tuberculosis Control Programme. ( 28410692 )
2017
50
Identification of Mycobacterium tuberculosis in Clinical Specimens of Patients Suspected of Having Extrapulmonary Tuberculosis by Application of Nested PCR on Five Different Genes. ( 28144587 )
2017

Variations for Extrapulmonary Tuberculosis

Expression for Extrapulmonary Tuberculosis

Search GEO for disease gene expression data for Extrapulmonary Tuberculosis.

Pathways for Extrapulmonary Tuberculosis

Pathways related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CCL2 IFNG IL10 IL1B MBL2 P2RX7
2
Show member pathways
12.78 CCL2 IFNG IL10 IL1B MBL2 P2RX7
3
Show member pathways
12.46 IFNG IL10 IL1B TLR2
4
Show member pathways
12.46 CCL2 IFNG IL1B TBP TLR2
5
Show member pathways
12.44 CCL2 IFNG IL10 IL1B
6 12.39 CCL2 IFNG IL10 IL1B TLR2
7
Show member pathways
12.22 CCL2 IFNG IL1B TLR2
8
Show member pathways
12.14 IFNG IL10 IL1B TLR2
9
Show member pathways
12.04 IFNG IL1B TIRAP TLR2
10 11.97 CCL2 IFNG IL1B
11
Show member pathways
11.95 CCL2 IFNG IL10 IL1B
12
Show member pathways
11.92 IFNG IL1B TLR2
13
Show member pathways
11.91 IFNG IL10 IL1B TLR2
14 11.89 CCL2 IFNG IL1B
15 11.86 CCL2 IL10 IL1B
16 11.72 IFNG IL10 IL1B TLR2
17 11.69 IFNG IL10 IL1B TIRAP TLR2 VDR
18 11.68 IFNG IL10 IL1B
19 11.66 IL10 IL1B TIRAP
20 11.66 CCL2 IFNG IL1B TLR2
21 11.64 IFNG IL10 IL1B
22 11.52 CCL2 IFNG IL10 IL1B
23 11.41 CCL2 IL10 IL1B
24 11.37 IFNG IL1B VDR
25 11.3 CCL2 IFNG IL1B TLR2
26 11.25 IFNG IL10 IL1B
27 11.1 IFNG IL10 IL1B
28 11.09 CCL2 IL10 IL1B TBP
29 10.96 CCL2 IFNG IL1B TLR2
30 10.83 CCL2 IL1B
31 10.71 CCL2 IFNG IL10 IL1B TLR2

GO Terms for Extrapulmonary Tuberculosis

Biological processes related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 CCL2 IFNG IL10 IL1B
2 negative regulation of cell proliferation GO:0008285 9.94 IL10 IL1B TLR2 VDR
3 cell surface receptor signaling pathway GO:0007166 9.87 CCL2 IFNG P2RX7 TIRAP
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B TIRAP TLR2
5 immune response GO:0006955 9.8 CCL2 IFNG IL10 IL1B SLC11A1 TLR2
6 response to bacterium GO:0009617 9.78 CCL2 P2RX7 SLC11A1
7 response to drug GO:0042493 9.77 ADA IL10 P2RX7
8 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 IL1B P2RX7
9 positive regulation of interleukin-6 production GO:0032755 9.7 IL1B P2RX7 TLR2
10 defense response to Gram-positive bacterium GO:0050830 9.67 MBL2 P2RX7 TIRAP TLR2
11 positive regulation of phagocytosis GO:0050766 9.65 IL1B MBL2 SLC11A1
12 positive regulation of T cell activation GO:0050870 9.64 ADA CCL2
13 defense response to protozoan GO:0042832 9.63 IL10 SLC11A1
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL2 IL1B TLR2
15 positive regulation of gene expression GO:0010628 9.63 IFNG IL1B P2RX7 SLC11A1 TLR2 VDR
16 response to ATP GO:0033198 9.62 IL1B P2RX7
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG IL1B
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B
19 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B TIRAP TLR2
20 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.6 CCL2 TLR2
21 response to molecule of bacterial origin GO:0002237 9.58 IL10 TLR2
22 cellular response to lipoteichoic acid GO:0071223 9.58 TIRAP TLR2
23 positive regulation of interleukin-12 production GO:0032735 9.58 IFNG TIRAP TLR2
24 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.55 IL1B TIRAP
25 positive regulation of prostaglandin secretion GO:0032308 9.54 IL1B P2RX7
26 cellular response to bacterial lipopeptide GO:0071221 9.51 TIRAP TLR2
27 inflammatory response GO:0006954 9.5 CCL2 IL10 IL1B P2RX7 SLC11A1 TIRAP
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG IL1B
29 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 MBL2 TIRAP
30 positive regulation of neutrophil chemotaxis GO:0090023 9.35 TIRAP
31 response to lipopolysaccharide GO:0032496 9.1 IL10 IL1B P2RX7 SLC11A1 TIRAP TLR2

Molecular functions related to Extrapulmonary Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL2 IFNG IL10 IL1B

Sources for Extrapulmonary Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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