MCID: EXT003
MIFTS: 24

Extraskeletal Mesenchymal Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Extraskeletal Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Extraskeletal Mesenchymal Chondrosarcoma:

Name: Extraskeletal Mesenchymal Chondrosarcoma 12 15 73
Mesenchymal Extraosseous Chondrosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4548
NCIt 50 C27481
SNOMED-CT 68 404080006
UMLS 73 C1275279

Summaries for Extraskeletal Mesenchymal Chondrosarcoma

MalaCards based summary : Extraskeletal Mesenchymal Chondrosarcoma, also known as mesenchymal extraosseous chondrosarcoma, is related to chondrosarcoma and mesenchymal chondrosarcoma. An important gene associated with Extraskeletal Mesenchymal Chondrosarcoma is SSX1 (SSX Family Member 1), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Affiliated tissues include kidney, heart and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Extraskeletal Mesenchymal Chondrosarcoma

Diseases related to Extraskeletal Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 10.8
2 mesenchymal chondrosarcoma 10.8
3 hemihyperplasia, isolated 10.0
4 cervicitis 10.0
5 epithelioid cell synovial sarcoma 9.9 SSX1 SSX2B
6 synovium cancer 9.9 SSX1 SSX2B
7 spindle cell synovial sarcoma 9.8 SSX1 SSX2B
8 sarcoma, synovial 9.7 SSX1 SSX2B
9 sarcoma 9.4 SSX1 SSX2B
10 connective tissue cancer 9.0 ENO2 SSX1 SSX2B

Graphical network of the top 20 diseases related to Extraskeletal Mesenchymal Chondrosarcoma:



Diseases related to Extraskeletal Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Extraskeletal Mesenchymal Chondrosarcoma

GenomeRNAi Phenotypes related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.66 SSX2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.66 AGO2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.66 AGO2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 SSX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.66 AGO2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.66 AGO2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.66 AGO2 SSX1 SSX2B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.66 AGO2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.66 AGO2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 SSX2B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.66 SSX1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.66 SSX2B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 AGO2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 SSX2B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.66 SSX1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 SSX1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.66 AGO2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.66 SSX2B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.66 SSX2B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 AGO2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.56 CYP1A2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.56 SSX2B CYP1A2
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.56 CYP1A2
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.56 SSX2B
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.56 CYP1A2
26 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.56 CYP1A2
27 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.56 SSX2B

Drugs & Therapeutics for Extraskeletal Mesenchymal Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Extraskeletal Mesenchymal Chondrosarcoma

Genetic Tests for Extraskeletal Mesenchymal Chondrosarcoma

Anatomical Context for Extraskeletal Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Extraskeletal Mesenchymal Chondrosarcoma:

41
Kidney, Heart, Pancreas, Spleen

Publications for Extraskeletal Mesenchymal Chondrosarcoma

Articles related to Extraskeletal Mesenchymal Chondrosarcoma:

(show all 50)
# Title Authors Year
1
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 29332118 )
2018
2
Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Clinical Mimicry as Glomus Jugulare. ( 28867901 )
2017
3
Extraskeletal mesenchymal chondrosarcoma at unusual location involving spleen and kidney with review of literature. ( 28631650 )
2017
4
What Is Your Diagnosis? Extraskeletal mesenchymal chondrosarcoma. ( 28857701 )
2017
5
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 28917072 )
2017
6
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
7
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
8
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case. ( 28164050 )
2016
9
Imaging features of extraskeletal mesenchymal chondrosarcoma of the hand. ( 25797212 )
2015
10
A rare case of extraskeletal mesenchymal chondrosarcoma with dedifferentiation arising from the buccal space in a young male. ( 25838713 )
2015
11
Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. ( 24932271 )
2014
12
Management of renal extraskeletal mesenchymal chondrosarcoma. ( 25511186 )
2014
13
Primary extraskeletal mesenchymal chondrosarcoma of the vulva. ( 24328027 )
2013
14
Primary extraskeletal mesenchymal chondrosarcoma of the anterior mediastinum. ( 24255641 )
2013
15
Radiological features and pathology of extraskeletal mesenchymal chondrosarcoma. ( 22726976 )
2012
16
Extraskeletal mesenchymal chondrosarcoma in the axillary region: reports of two cases. ( 23136576 )
2012
17
Extraskeletal mesenchymal chondrosarcoma of the pleura: report of a rare case. ( 21393900 )
2011
18
Intramuscular, extraskeletal mesenchymal chondrosarcoma. ( 23548257 )
2011
19
Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. ( 20014564 )
2009
20
Extraskeletal mesenchymal chondrosarcoma of the cervical meninx. ( 17705006 )
2007
21
Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma: a computed tomography diagnosis. ( 17989325 )
2007
22
Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. ( 17336849 )
2007
23
Primary extraskeletal mesenchymal chondrosarcoma arising from the pancreas. ( 18071285 )
2007
24
Extraskeletal mesenchymal chondrosarcoma of the heart responded to systemic chemotherapy: a case report. ( 19746223 )
2007
25
Intracranial extraskeletal mesenchymal chondrosarcoma. ( 22266623 )
2006
26
Extraskeletal mesenchymal chondrosarcoma of the kidney. ( 16643625 )
2006
27
Extraskeletal mesenchymal chondrosarcoma: an imaging review of ten new patients. ( 16211384 )
2005
28
Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma. ( 15899388 )
2005
29
Cutaneous extraskeletal mesenchymal chondrosarcoma in a cat. ( 15842543 )
2005
30
Imprint cytology of extraskeletal mesenchymal chondrosarcoma of the perineum: a case report. ( 15471258 )
2004
31
Extraskeletal mesenchymal chondrosarcoma. ( 12908575 )
2003
32
Extraskeletal mesenchymal chondrosarcoma: case report. ( 12727057 )
2003
33
Retroperitoneal extraskeletal mesenchymal chondrosarcoma in a dog. ( 12423033 )
2002
34
Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. ( 12011263 )
2002
35
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. ( 10626952 )
2000
36
Extraskeletal mesenchymal chondrosarcoma involving the heart: report of a case. ( 10929746 )
2000
37
Extraskeletal mesenchymal chondrosarcoma of the rectus sheath. ( 9297757 )
1997
38
Primary extraskeletal mesenchymal chondrosarcoma in fossa poplitea of a 93-year-old woman. ( 8950579 )
1996
39
Cytogenetic study of extraskeletal mesenchymal chondrosarcoma. A case report. ( 8603349 )
1996
40
Extraskeletal mesenchymal chondrosarcoma of the labium majus. ( 8774664 )
1996
41
Extraskeletal mesenchymal chondrosarcoma of the orbit. ( 8374880 )
1993
42
Extraskeletal mesenchymal chondrosarcoma. ( 8430193 )
1993
43
Extraskeletal mesenchymal chondrosarcoma of the mediastinum. ( 2242853 )
1990
44
Extraskeletal mesenchymal chondrosarcoma in a cow. ( 2794151 )
1989
45
Extraskeletal mesenchymal chondrosarcoma: case report and review of the literature. ( 2409241 )
1985
46
An ultrastructural study of extraskeletal mesenchymal chondrosarcoma. ( 6524380 )
1984
47
Extraskeletal mesenchymal chondrosarcoma of the orbit. ( 7174941 )
1982
48
Case report. Extraskeletal mesenchymal chondrosarcoma. ( 750463 )
1978
49
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. ( 753003 )
1978
50
Extraskeletal mesenchymal chondrosarcoma. ( 4694076 )
1973

Variations for Extraskeletal Mesenchymal Chondrosarcoma

Cosmic variations for Extraskeletal Mesenchymal Chondrosarcoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6939344 INSR bone,extraskeletal,chondrosarcoma,mesenchymal c.1670C>T p.T557M 19:7166345-7166345 8
2 COSM150793 AR bone,extraskeletal,chondrosarcoma,mesenchymal c.2440T>G p.F814V 23:67721954-67721954 8
3 COSM6939346 bone,extraskeletal,chondrosarcoma,mesenchymal c.844T>G p.F282V 23:67721954-67721954 8
4 COSM1245279 bone,extraskeletal,chondrosarcoma,mesenchymal c.1870T>G p.F624V 23:67721954-67721954 8
5 COSM6939345 bone,extraskeletal,chondrosarcoma,mesenchymal c.1670C>T p.T557M 19:7166345-7166345 8

Expression for Extraskeletal Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Extraskeletal Mesenchymal Chondrosarcoma.

Pathways for Extraskeletal Mesenchymal Chondrosarcoma

Pathways related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.89 SSX1 SSX2B

GO Terms for Extraskeletal Mesenchymal Chondrosarcoma

Biological processes related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-embryonic development GO:0009791 8.96 AGO2 CYP1A2
2 negative regulation of nucleic acid-templated transcription GO:1903507 8.62 SSX1 SSX2B

Molecular functions related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription corepressor activity GO:0003714 8.96 SSX1 SSX2B
2 nucleic acid binding GO:0003676 8.8 AGO2 SSX1 SSX2B

Sources for Extraskeletal Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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