MCID: EXT009
MIFTS: 28

Extratemporal Epilepsy

Categories: Neuronal diseases

Aliases & Classifications for Extratemporal Epilepsy

MalaCards integrated aliases for Extratemporal Epilepsy:

Name: Extratemporal Epilepsy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2544
NCIt 50 C7760
UMLS 73 C0270849

Summaries for Extratemporal Epilepsy

Disease Ontology : 12 An epilepsy syndrome that is located in an area of the brain other than the temporal lobe.

MalaCards based summary : Extratemporal Epilepsy is related to epilepsy and hypohidrotic ectodermal dysplasia autosomal recessive. An important gene associated with Extratemporal Epilepsy is SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1), and among its related pathways/superpathways are Thromboxane A2 receptor signaling and Alpha-synuclein signaling. Affiliated tissues include brain, temporal lobe and lung, and related phenotypes are cellular and mortality/aging

Related Diseases for Extratemporal Epilepsy

Graphical network of the top 20 diseases related to Extratemporal Epilepsy:



Diseases related to Extratemporal Epilepsy

Symptoms & Phenotypes for Extratemporal Epilepsy

MGI Mouse Phenotypes related to Extratemporal Epilepsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 CLIP1 EDAR EXT1 PLP1 SMUG1 TGM2
2 mortality/aging MP:0010768 9.28 EDAR EXT1 HCK KHDRBS3 MYRF PLP1

Drugs & Therapeutics for Extratemporal Epilepsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers Recruiting NCT03464370 Not Applicable

Search NIH Clinical Center for Extratemporal Epilepsy

Genetic Tests for Extratemporal Epilepsy

Anatomical Context for Extratemporal Epilepsy

MalaCards organs/tissues related to Extratemporal Epilepsy:

41
Brain, Temporal Lobe, Lung, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Extratemporal Epilepsy:

19
An Area Of The Brain Other Than The Temporal Lobe

Publications for Extratemporal Epilepsy

Articles related to Extratemporal Epilepsy:

(show top 50) (show all 58)
# Title Authors Year
1
Multimodal Imaging in Extratemporal Epilepsy Surgery. ( 29796351 )
2018
2
Surgical Treatment of Extratemporal Epilepsy: Results and Prognostic Factors. ( 29618099 )
2018
3
The oxymoron of image-guided resection in 3a8^T MRI-negative extratemporal epilepsy: Technique and postoperative results. ( 29358107 )
2018
4
Role of resting state MRI temporal latency in refractory pediatric extratemporal epilepsy lateralization. ( 30350326 )
2018
5
Resection planning in extratemporal epilepsy surgery using 3D multimodality imaging and intraoperative MRI. ( 27931117 )
2016
6
PET imaging in extratemporal epilepsy requires consideration of electroclinical findings. ( 27399879 )
2016
7
Antiepileptic medications after extratemporal epilepsy surgery: when do we stop? ( 23447729 )
2013
8
Ictal PET in presurgical workup of refractory extratemporal epilepsy. ( 24339606 )
2013
9
Identifying the cortical substrates of interictal epileptiform activity in patients with extratemporal epilepsy: An EEG-fMRI sequential analysis and FDG-PET study. ( 23362864 )
2013
10
Surgical outcomes in patients with extratemporal epilepsy and subtle or normal magnetic resonance imaging findings. ( 23615090 )
2013
11
Long-term outcome and predictors of resective surgery prognosis in patients with refractory extratemporal epilepsy. ( 24378203 )
2013
12
Comparing the effects of cortical resection and vagus nerve stimulation in patients with nonlesional extratemporal epilepsy. ( 23892577 )
2013
13
Integration of functional neuronavigation and intraoperative MRI in surgery for drug-resistant extratemporal epilepsy close to eloquent brain areas. ( 23544410 )
2013
14
SISCOM and FDG-PET in patients with non-lesional extratemporal epilepsy: correlation with intracranial EEG, histology, and seizure outcome. ( 23531745 )
2013
15
Scalp and intracranial EEG in medically intractable extratemporal epilepsy with normal MRI. ( 22792484 )
2012
16
Seizure outcome after extratemporal epilepsy surgery in childhood. ( 22816374 )
2012
17
Surgical management of medial extratemporal epilepsy. ( 22939075 )
2012
18
Individually tailored extratemporal epilepsy surgery in children: anatomo-electro-clinical features and outcome predictors in a population of 53 cases. ( 22902651 )
2012
19
Long-term seizure outcome and risk factors for recurrence after extratemporal epilepsy surgery. ( 22417071 )
2012
20
Excellent outcomes after extratemporal epilepsy surgery in children. ( 22861682 )
2012
21
Social outcomes after temporal or extratemporal epilepsy surgery: a systematic review. ( 21561446 )
2011
22
Cognitive outcome after extratemporal epilepsy surgery in childhood. ( 22032791 )
2011
23
An outcome analysis of seventeen patients treated surgically for intractable extratemporal epilepsy. ( 20845601 )
2010
24
Intracranial electroencephalography seizure onset patterns and surgical outcomes in nonlesional extratemporal epilepsy. ( 19072306 )
2009
25
Predictors of quality of life after resective extratemporal epilepsy surgery in adults in long-term follow-up. ( 19428270 )
2009
26
The impact of extratemporal epilepsy surgery on quality of life. ( 19250976 )
2009
27
Psychosocial outcome after extratemporal epilepsy surgery: a prospective clinical study. ( 18597225 )
2008
28
Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. ( 18596454 )
2008
29
Outcome of extratemporal epilepsy surgery experience of a single center. ( 18812963 )
2008
30
Pediatric extratemporal epilepsy presenting with a complex auditory aura. ( 18539574 )
2008
31
Long-term outcome of extratemporal epilepsy surgery among 154 adult patients. ( 18377245 )
2008
32
Quality of life after extratemporal epilepsy surgery: a prospective clinical study. ( 17919811 )
2008
33
Presurgical seizure frequency and tumoral etiology predict the outcome after extratemporal epilepsy surgery. ( 17486287 )
2007
34
(1)H MR spectroscopic imaging in patients with MRI-negative extratemporal epilepsy: correlation with ictal onset zone and histopathology. ( 17340102 )
2007
35
Pre-surgical evaluation and surgical treatment in children with extratemporal epilepsy. ( 16832668 )
2006
36
Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. ( 15670380 )
2005
37
Surgical Treatment for Extratemporal Epilepsy. ( 15043808 )
2004
38
Comparison of magnetoencephalographic spikes with and without concurrent electroencephalographic spikes in extratemporal epilepsy. ( 15240925 )
2004
39
Ictal SPECT in nonlesional extratemporal epilepsy. ( 15281955 )
2004
40
Successful selection of patients with intractable extratemporal epilepsy using non-invasive investigations. ( 14630496 )
2003
41
Magnetoencephalographically directed review of high-spatial-resolution surface-coil MR images improves lesion detection in patients with extratemporal epilepsy. ( 12461274 )
2002
42
The absence of interictal spikes with documented seizures suggests extratemporal epilepsy. ( 11422335 )
2001
43
Results of surgery in patients with refractory extratemporal epilepsy with normal or nonlocalizing magnetic resonance findings investigated with subdural grids. ( 11488889 )
2001
44
Ictal ECD-SPECT differentiates between temporal and extratemporal epilepsy: confirmation by excellent postoperative seizure control. ( 11258411 )
2001
45
Curved reconstructions versus three-dimensional surface rendering in the demonstration of cortical lesions in patients with extratemporal epilepsy. ( 11283420 )
2001
46
Extratemporal epilepsy in children: candidate selection and surgical treatment. ( 11156299 )
2000
47
Interictal, unifocal spikes in refractory extratemporal epilepsy predict ictal origin and postsurgical outcome. ( 11018495 )
2000
48
Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome. ( 11113221 )
2000
49
Magnetoencephalography in extratemporal epilepsy. ( 10831110 )
2000
50
Focal extratemporal epilepsy: clinical features, EEG patterns, and surgical approach. ( 10465493 )
1999

Variations for Extratemporal Epilepsy

Expression for Extratemporal Epilepsy

Search GEO for disease gene expression data for Extratemporal Epilepsy.

Pathways for Extratemporal Epilepsy

Pathways related to Extratemporal Epilepsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.61 HCK TGM2
2 10.13 HCK TOR1A

GO Terms for Extratemporal Epilepsy

Biological processes related to Extratemporal Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.32 EXT1 HAS1
2 hair follicle development GO:0001942 9.26 EDAR WNT10A
3 mesoderm development GO:0007498 9.16 EXT1 HCK
4 central nervous system myelination GO:0022010 8.96 MYRF PLP1
5 salivary gland cavitation GO:0060662 8.62 EDAR TGM2

Sources for Extratemporal Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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