HP
MCID: EXT034
MIFTS: 58

Extrinsic Allergic Alveolitis (HP)

Categories: Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Extrinsic Allergic Alveolitis

MalaCards integrated aliases for Extrinsic Allergic Alveolitis:

Name: Extrinsic Allergic Alveolitis 12 37 15 73
Alveolitis 12 55 15 73
Alveolitis, Extrinsic Allergic 76 53 44
Hypersensitivity Pneumonitis 12 53 63
Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis 53
Allergic Interstitial Pneumonitis 53
Pneumonitis Hypersensitivity 55
Allergic Pneumonitis 53
Hp 53

Classifications:



External Ids:

Disease Ontology 12 DOID:841
ICD10 33 J67.9 J67 J67.8
ICD9CM 35 495 495.9
MeSH 44 D000542
NCIt 50 C34369
SNOMED-CT 68 37471005
KEGG 37 H00346

Summaries for Extrinsic Allergic Alveolitis

PubMed Health : 63 About hypersensitivity pneumonitis: Hypersensitivity pneumonitis (noo-mo-NI-tis), or HP, is a disease in which the lungs become inflamed from breathing in foreign substances, such as molds, dusts, and chemicals. These substances also are known as antigens (AN-tih-jens).People are exposed to antigens at home, while at work, and in other settings. However, most people who breathe in these substances don't develop HP.

MalaCards based summary : Extrinsic Allergic Alveolitis, also known as alveolitis, is related to bagassosis and hemophagocytic lymphohistiocytosis, and has symptoms including hemoptysis An important gene associated with Extrinsic Allergic Alveolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Pirfenidone and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

Wikipedia : 76 Hypersensitivity pneumonitis (HP; also called allergic alveolitis, bagpipe lung, or extrinsic allergic... more...

Related Diseases for Extrinsic Allergic Alveolitis

Diseases related to Extrinsic Allergic Alveolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 473)
# Related Disease Score Top Affiliating Genes
1 bagassosis 32.4 CXCL8 IL1B IL6
2 hemophagocytic lymphohistiocytosis 32.3 CXCL8 IL10 IL18 IL2RA
3 endometrial disease 31.8 CXCL8 IL1B IL6
4 vaginal disease 31.8 CXCL8 IL1B IL6
5 heart disease 31.7 ALB CXCL8 IL10 IL1B IL6
6 mastitis 31.6 ALB CCL5 CXCL8 IL6
7 idiopathic interstitial pneumonia 31.6 CCL2 CXCL8 SFTPD
8 vascular disease 31.4 ALB CCL2 IL6 MPO
9 trypanosomiasis 31.4 ALB CCL2 CCL5 CXCL8 IL10 IL1B
10 parasitic protozoa infectious disease 31.4 IL10 IL1B IL6
11 malaria 31.1 ALB CCL2 CCL5 CXCL8 CXCR3 IL10
12 tropical spastic paraparesis 31.1 CCL5 CXCR3 IL10 IL2RA IL6
13 sleep apnea 30.5 CXCL8 IL1B IL6
14 pulmonary fibrosis 30.5 CCL2 IL1B SFTPD
15 melioidosis 30.2 IL10 IL18 IL6
16 helicobacter pylori infection 30.1 CCL5 CXCL8 IL1B
17 ulcerative colitis 30.1 CXCL8 IL10 IL1B IL6 MPO
18 bronchitis 30.1 ALB CXCL8 MPO
19 microscopic polyangiitis 30.0 IL10 MPO
20 bronchiolitis 30.0 CCL5 CXCL8 IL10 IL6
21 hemorrhagic fever 30.0 ALB IL10 IL6
22 hemorrhagic fever with renal syndrome 30.0 ALB CXCL8 IL6
23 graft-versus-host disease 30.0 IL10 IL1B IL6
24 toxoplasmosis 29.9 IL10 IL1B IL6
25 transverse myelitis 29.9 CXCL8 IL10 IL6
26 allergic hypersensitivity disease 29.9 CCL5 FCER2 IL10
27 diabetic foot ulcers 29.9 CCL2 IL6
28 pulpitis 29.9 CXCL8 IL1B IL6
29 respiratory failure 29.9 ALB CXCL8 SFTPD
30 human immunodeficiency virus infectious disease 29.8 CCL5 IL10 IL6
31 adult respiratory distress syndrome 29.8 CXCL8 IL10 IL6
32 osteomyelitis 29.8 CXCL8 IL10 IL1B IL6
33 viral infectious disease 29.8 CCL5 CXCL8 IL10 IL1B IL6
34 colitis 29.7 CXCL8 IL10 IL1B IL6 MPO
35 fasciitis 29.7 CXCL8 IL18 IL6
36 pulmonary edema 29.7 CXCL8 IL10 IL1B
37 gingivitis 29.7 CXCL8 IL1B IL6
38 acute respiratory distress syndrome 29.7 CXCL8 IL1B IL6 PI3 SFTPD
39 bronchiolitis obliterans 29.7 CXCL8 CXCR3 IL10 IL6
40 chronic graft versus host disease 29.7 ALB IL10 IL2RA
41 arthritis 29.6 CCL2 CXCL8 IL10 IL18 IL1B IL6
42 juvenile rheumatoid arthritis 29.6 IL18 IL1B IL2RA IL6
43 pneumonia 29.5 CCL2 CCL5 CXCL8 IL10 IL1B IL6
44 chronic eosinophilic pneumonia 29.5 CCL2 CCL5 CXCR3
45 diabetes mellitus 29.5 ALB IL1B IL2RA IL6 SOD2
46 interstitial lung disease 29.5 CCL2 CCL5 CXCL8 IL10 IL1B IL6
47 bone inflammation disease 29.5 CCL2 CXCL8 IL10 IL1B IL6
48 stachybotrys chartarum 29.4 CCL2 CCL5 IL18 IL1B IL6
49 silicosis 29.4 CCL2 CXCL8 IL1B SFTPD
50 glomerulonephritis 29.4 ALB CCL2 IL1B MPO

Comorbidity relations with Extrinsic Allergic Alveolitis via Phenotypic Disease Network (PDN):


Heart Disease Postinflammatory Pulmonary Fibrosis

Graphical network of the top 20 diseases related to Extrinsic Allergic Alveolitis:



Diseases related to Extrinsic Allergic Alveolitis

Symptoms & Phenotypes for Extrinsic Allergic Alveolitis

UMLS symptoms related to Extrinsic Allergic Alveolitis:


hemoptysis

GenomeRNAi Phenotypes related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 IL10 IL18 IL1B IL2RA MPO
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 IL10 IL18 IL1B IL2RA MPO

MGI Mouse Phenotypes related to Extrinsic Allergic Alveolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 CCL5 CXCR3 FCER2 IL10 IL18 IL1B
2 homeostasis/metabolism MP:0005376 10 ALB CXCR3 FCER2 IL10 IL18 IL1B
3 immune system MP:0005387 9.93 CCL2 CCL5 CXCR3 FCER2 IL10 IL18
4 mortality/aging MP:0010768 9.7 ALB CXCR3 FCER2 IL10 IL18 IL1B
5 neoplasm MP:0002006 9.1 ALB CXCR3 IL10 IL1B IL6 SOD2

Drugs & Therapeutics for Extrinsic Allergic Alveolitis

PubMedHealth treatment related to Extrinsic Allergic Alveolitis: 63

The best way to treat hypersensitivity pneumonitis (HP) is to avoid the antigen that caused it. (An antigen is a substance that your body reacts against, such as molds, dusts, and chemicals.)In acute (short-term) HP, symptoms usually go away once you're no longer in contact with the antigen. In chronic (ongoing) HP, you may need medicines to relieve your symptoms.People who have chronic HP may develop pulmonary fibrosis. This is a condition in which tissue deep in your lungs becomes scarred over time. People who have this condition may need further treatment, such as oxygen therapy and pulmonary rehabilitation (rehab).

Drugs for Extrinsic Allergic Alveolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 2, Phase 3,Not Applicable 53179-13-8 40632
2
Azathioprine Approved Phase 2, Phase 3 446-86-6 2265
3
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
4 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
5 Peripheral Nervous System Agents Phase 2, Phase 3,Not Applicable
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
7 Antineoplastic Agents, Hormonal Phase 2, Phase 3
8 Analgesics Phase 2, Phase 3,Not Applicable
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Not Applicable
10 Immunosuppressive Agents Phase 2, Phase 3
11 Antimetabolites, Antineoplastic Phase 2, Phase 3
12 Antirheumatic Agents Phase 2, Phase 3,Not Applicable
13 Antimetabolites Phase 2, Phase 3
14 Hormone Antagonists Phase 2, Phase 3
15 Immunologic Factors Phase 2, Phase 3
16 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
17 glucocorticoids Phase 2, Phase 3
18 Hormones Phase 2, Phase 3
19
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
20
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
21
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
22
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
23
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
24 Autonomic Agents Phase 2,Not Applicable
25 Protective Agents Phase 2
26 Neuroprotective Agents Phase 2
27 Antiemetics Phase 2
28 Prednisolone acetate Phase 2
29 Methylprednisolone acetate Phase 2
30 Gastrointestinal Agents Phase 2
31
Heparin Approved, Investigational 9005-49-6 772 46507594
32 Pharmaceutical Solutions
33 calcium heparin
34 Pepsin A
35 Neurotransmitter Agents Not Applicable
36 Tocolytic Agents Not Applicable
37 Anti-Asthmatic Agents Not Applicable
38 Adrenergic beta-Agonists Not Applicable
39 Albuterol Not Applicable
40 Adrenergic Agonists Not Applicable
41 Respiratory System Agents Not Applicable
42 Bronchodilator Agents Not Applicable
43 Adrenergic Agents Not Applicable
44 Adrenergic beta-2 Receptor Agonists Not Applicable
45 Immunoglobulins Not Applicable
46 Antibodies Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Pirfenidone in the Chronic Hypersensitivity Pneumonitis Treatment Unknown status NCT02496182 Phase 2, Phase 3 Placebo;Pirfenidone;Pirfenidone
2 Stop Exogenous Allergic Alveolitis (EAA) in Childhood Suspended NCT02631603 Phase 2 Placebo;Prednisolone
3 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
4 The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis Unknown status NCT01714934
5 Small Airway Involvement in Patients With Chronic Hypersensitivity Pneumonitis Completed NCT02523833 Not Applicable Salbutamol
6 Bronchoalveolar Immune Response Determination Completed NCT01237145
7 Wind Instruments' Fungal Contamination Completed NCT01487850 Not Applicable
8 Work-related Respiratory Symptoms in Champagne Vineyard Workers Completed NCT02883920
9 Explorative Study on the Molecular Pathology of Lung Fibrosis by Combination of Clinical Assessment and System Biology Completed NCT01687946
10 Supplemental Oxygen in Pulmonary Fibrosis Completed NCT01961362
11 Study of Efficacy and Safety of Pirfenidone in Patients With Fibrotic Hypersensitivity Pneumonitis Recruiting NCT02958917 Not Applicable Pirfenidone
12 Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung Recruiting NCT03056404 Not Applicable
13 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
14 Toward Self-management in ILD Recruiting NCT03300583
15 Pulmonary Fibrosis Contact Registry Recruiting NCT01935726
16 Lung MRI in the Management of Idiopathic Pulmonary Fibrosis Recruiting NCT03078426 Not Applicable
17 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416
18 Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry Active, not recruiting NCT01915511
19 Pulmonary Hypertension in Hypersensitivity Pneumonitis Enrolling by invitation NCT03030807
20 BPF Genetics of ILD Study Not yet recruiting NCT03747627
21 Skeletal Muscle Function in Interstitial Lung Disease Not yet recruiting NCT03800017 Not Applicable

Search NIH Clinical Center for Extrinsic Allergic Alveolitis

Cochrane evidence based reviews: alveolitis, extrinsic allergic

Genetic Tests for Extrinsic Allergic Alveolitis

Anatomical Context for Extrinsic Allergic Alveolitis

MalaCards organs/tissues related to Extrinsic Allergic Alveolitis:

41
Lung, Neutrophil, T Cells, Testes, Brain, Liver, Bone

Publications for Extrinsic Allergic Alveolitis

Articles related to Extrinsic Allergic Alveolitis:

(show top 50) (show all 818)
# Title Authors Year
1
Radiation Pneumonitis with Eosinophilic Alveolitis in a Lung Cancer Patient. ( 29279483 )
2018
2
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. ( 29723658 )
2018
3
Hypersensitivity pneumonitis: A fibrosing alveolitis produced by inhalation of diverse antigens. ( 30448501 )
2018
4
The diagnostic importance of the bronchoalveolar lavage in lymphocytic alveolitis. ( 27471881 )
2017
5
Differences in Texture Analysis Parameters Between Active Alveolitis and Lung Fibrosis in Chest CT of Patients with Systemic Sclerosis: A Feasibility Study. ( 28807589 )
2017
6
Relationship between obstructive sleep apnea syndrome and metabolic syndrome in a patient with chronic extrinsic allergic alveolitis. ( 29542906 )
2016
7
Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis. ( 27591866 )
2016
8
HIV Suppression Restores the Lung Mucosal CD4+ T-Cell Viral Immune Response and Resolves CD8+ T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease. ( 27613775 )
2016
9
Neutrophilic Alveolitis and High Serum Pro-Brain Natriuretic Peptide Level may be Indicators of Pulmonary Functional Impairment in Connective Tissue Disorders. ( 29900993 )
2016
10
Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis). ( 25914724 )
2015
11
Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. ( 25536276 )
2015
12
Can serial PEF measurements separate occupational asthma from allergic alveolitis? ( 25825508 )
2015
13
Migratory eosinophilic alveolitis caused by radiation therapy. ( 26101656 )
2015
14
Serial peak flow measurements in allergic alveolitis. ( 26240129 )
2015
15
Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis. ( 26469087 )
2015
16
Influence of age on manifestation, VC and TLCO values and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis: Fibrotic response as a hallmark of aging? ( 24406019 )
2014
17
PAR-2, IL-4R, TGF-I^ and TNF-I+ in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis. ( 25009615 )
2014
18
Hypersensitivity pneumonitis (extrinsic allergic alveolitis): A Canadian historical perspective. ( 25299221 )
2014
19
Lesson of the month: extrinsic allergic (bronchiolo)alveolitis and metal working fluids. ( 25005567 )
2014
20
Linear and nonlinear analysis of base lung sound in extrinsic allergic alveolitis patients in comparison to healthy subjects. ( 23591730 )
2013
21
Role of interleukin 4 and its receptor in clinical presentation of chronic extrinsic allergic alveolitis: a pilot study. ( 23721656 )
2013
22
Acute alveolitis following infliximab therapy for psoriasis. ( 22780696 )
2013
23
Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice. ( 23752613 )
2013
24
Lupus erythematosus cell phenomenon in pediatric bronchoalveolar lavages: possible manifestation of early radioadaptive response in radiation induced alveolitis. ( 23830389 )
2013
25
Extrinsic allergic alveolitis as an uncommon diagnostic pitfall in lung cytology. ( 21656702 )
2012
26
Surfactant protein A in chronic extrinsic allergic alveolitis. ( 22654012 )
2012
27
New occupational and environmental causes of asthma and extrinsic allergic alveolitis. ( 23153603 )
2012
28
Perialveolar bacterial microbiota and bacteraemia after dental alveolitis in adult rats that had been subjected to neonatal malnutrition. ( 21816120 )
2012
29
Lethal hemorrhagic alveolitis after adenovirus pneumonia in a lung transplant recipient. ( 22054722 )
2012
30
Fatal fibrosing alveolitis with certolizumab. ( 22328567 )
2012
31
Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: serological methods in EAA. ( 21924863 )
2011
32
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. ( 21704503 )
2011
33
Acute life-threatening extrinsic allergic alveolitis in a paint controller. ( 21824996 )
2011
34
Pre-clinical detection of amiodarone-induced acute fibrosing alveolitis by intra-thoracic impedance monitor of an implantable cardioverter-defibrillator. ( 20851824 )
2011
35
Clozapine-induced lymphocytic alveolitis. ( 21297049 )
2011
36
Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse. ( 21342009 )
2011
37
Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing. ( 21625744 )
2011
38
Chronic pulmonary thromboembolism pathologically showing homogeneous cellular alveolitis. ( 21963740 )
2011
39
Toxic alveolitis after inhalation of a water repellent. ( 22002324 )
2011
40
Angiogenic activity of sera from extrinsic allergic alveolitis patients in relation to clinical, radiological, and functional pulmonary changes. ( 20607270 )
2010
41
Cryptogenic fibrosing alveolitis and lung cancer: the BTS study. ( 19996344 )
2010
42
Bronchoalveolar lavage and response to cyclophosphamide in scleroderma alveolitis. ( 20059446 )
2010
43
Gene expression profiling distinguishes radiation-induced fibrosing alveolitis from alveolitis in mice. ( 20334524 )
2010
44
Morphometric and DNA image analysis of bronchoalveolar lavage fluid macrophages nuclei in interstitial lung diseases with lymphocytic alveolitis. ( 20432740 )
2010
45
Clinical features and prognosis in 21 patients with extrinsic allergic alveolitis. ( 20120765 )
2009
46
Extrinsic allergic alveolitis with an atypical immune expression. ( 19280076 )
2009
47
Infliximab-associated alveolitis after treatment for severe left-sided ulcerative colitis. ( 19398919 )
2009
48
Malt can cause both occupational asthma and allergic alveolitis. ( 19416137 )
2009
49
A novel inhalation challenge set to study animal model of allergic alveolitis. ( 19572490 )
2009
50
Effect of Mercurius solubilis on the bacteriological response in the alveolitis process in rats. ( 19647210 )
2009

Variations for Extrinsic Allergic Alveolitis

Expression for Extrinsic Allergic Alveolitis

Search GEO for disease gene expression data for Extrinsic Allergic Alveolitis.

Pathways for Extrinsic Allergic Alveolitis

Pathways related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CCL2 CCL5 CXCL8 FCER2 IL10 IL18
2
Show member pathways
13.86 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
3
Show member pathways
13.58 CCL2 CCL5 CXCL5 CXCL8 CXCR3 FCER2
4
Show member pathways
13.55 CCL2 CCL5 CXCL8 IL10 IL18 IL1B
5
Show member pathways
13.39 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
6
Show member pathways
13.36 CCL2 CCL5 CXCL8 FCER2 IL10 IL18
7
Show member pathways
13.24 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
8
Show member pathways
13.01 CCL2 CCL5 CXCL8 IL10 IL18 IL1B
9
Show member pathways
12.9 CXCL8 IL10 IL18 IL1B IL2RA IL6
10
Show member pathways
12.88 CCL2 CCL5 CXCL5 CXCL8 CXCR3
11
Show member pathways
12.82 CCL2 CCL5 CXCL8 IL18 IL1B IL2RA
12
Show member pathways
12.78 CCL5 CXCL8 IL18 IL1B IL6
13
Show member pathways
12.63 IL10 IL18 IL1B IL2RA IL6
14
Show member pathways
12.63 CCL2 IL10 IL18 IL1B IL6 MPO
15 12.6 CCL2 CCL5 IL10 IL1B IL2RA MPO
16
Show member pathways
12.36 CCL2 CXCL5 CXCL8 IL1B IL6
17
Show member pathways
12.31 CXCL8 IL10 IL18 IL1B IL2RA IL6
18
Show member pathways
12.31 ALB CCL2 CCL5 IL1B IL6 MPO
19 12.27 IL10 IL18 IL1B IL6
20
Show member pathways
12.25 CXCL8 IL18 IL1B IL6
21
Show member pathways
12.24 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL1B
22
Show member pathways
12.22 CXCL8 IL1B IL6 SFTPD
23 12.21 CXCL8 IL10 IL1B IL6
24
Show member pathways
12.09 IL10 IL18 IL1B IL6
25 12.05 CCL2 CXCL8 IL1B IL6
26
Show member pathways
12.05 CCL2 CCL5 CXCL5 CXCL8 CXCR3
27 12.02 IL10 IL2RA IL6 MPO
28
Show member pathways
12.02 CCL2 CCL5 CXCL8 IL10 IL18 IL1B
29 12.01 CCL2 CCL5 CXCL5 IL1B IL6
30
Show member pathways
11.95 IL18 IL1B IL2RA
31 11.95 CCL2 CXCL8 IL1B IL6
32 11.93 FCER2 IL1B IL2RA IL6
33 11.93 CXCL8 IL10 IL1B IL6
34 11.92 CXCL8 IL1B IL6
35 11.87 CXCL8 IL18 IL1B IL6
36 11.86 CCL2 CXCL8 FCER2 IL10 IL18 IL1B
37 11.85 IL10 IL2RA IL6
38 11.84 CXCR3 IL10 IL18 IL1B IL2RA
39 11.8 CXCL5 CXCL8 IL10 IL1B IL6
40 11.77 IL10 IL1B IL6
41 11.7 CCL2 CCL5 IL10 IL18 IL1B IL6
42
Show member pathways
11.69 CXCL8 IL1B IL6
43 11.69 CCL2 CCL5 CXCL8 IL1B IL6
44 11.65 CXCL8 IL18 IL1B IL6
45 11.56 CCL2 IL18 IL1B
46 11.55 CXCL8 IL2RA IL6
47 11.49 CCL2 CXCL8 IL10 IL18 IL1B IL6
48 11.45 CCL2 CCL5 CXCL5 CXCL8 IL18 IL1B
49 11.42 IL10 IL18 IL1B IL6
50 11.41 IL10 IL1B IL6

GO Terms for Extrinsic Allergic Alveolitis

Cellular components related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ALB CCL2 CCL5 CXCL5 CXCL8 IL10
2 extracellular region GO:0005576 9.44 ALB CCL2 CCL5 CXCL5 CXCL8 FCER2

Biological processes related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.95 CCL2 CXCL8 CXCR3 IL18
2 MAPK cascade GO:0000165 9.95 CCL2 CCL5 IL18 IL1B IL2RA
3 cell-cell signaling GO:0007267 9.94 CCL5 CXCL5 IL18 IL1B
4 chemotaxis GO:0006935 9.88 CCL2 CCL5 CXCL5 CXCL8 CXCR3
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 IL10 IL1B IL6
6 cell chemotaxis GO:0060326 9.86 CCL2 CCL5 CXCL5 CXCR3
7 regulation of signaling receptor activity GO:0010469 9.86 CCL2 CCL5 CXCL5 CXCL8 IL10 IL18
8 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 CCL5 IL18 IL1B
9 cellular response to interleukin-1 GO:0071347 9.83 CCL2 CCL5 CXCL8
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 CCL5 IL18 IL6
11 response to glucocorticoid GO:0051384 9.81 IL10 IL1B IL6
12 positive regulation of T cell proliferation GO:0042102 9.81 CCL5 IL1B IL2RA IL6
13 inflammatory response GO:0006954 9.81 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 CCL5 IL18 IL6
15 neutrophil chemotaxis GO:0030593 9.8 CCL2 CCL5 CXCL5 CXCL8 IL1B
16 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL5 CXCL8 IL10 IL1B IL6
17 monocyte chemotaxis GO:0002548 9.77 CCL2 CCL5 IL6
18 negative regulation of T cell proliferation GO:0042130 9.77 IL10 IL2RA SFTPD
19 chemokine-mediated signaling pathway GO:0070098 9.77 CCL2 CCL5 CXCL5 CXCL8 CXCR3
20 protein kinase B signaling GO:0043491 9.76 CCL2 CCL5 IL1B
21 cellular response to fibroblast growth factor stimulus GO:0044344 9.75 CCL2 CCL5 CXCL8
22 leukocyte chemotaxis GO:0030595 9.74 CXCL5 CXCL8 IL10
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 CCL2 CCL5 IL18 IL1B
24 macrophage chemotaxis GO:0048246 9.7 CCL2 CCL5 SFTPD
25 positive regulation of glial cell proliferation GO:0060252 9.68 IL1B IL6
26 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 MPO
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 IL1B
28 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 FCER2
29 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.67 CCL5 CXCL8
30 removal of superoxide radicals GO:0019430 9.67 MPO SOD2
31 neutrophil activation GO:0042119 9.67 CCL5 CXCL8 IL18
32 PERK-mediated unfolded protein response GO:0036499 9.66 CCL2 CXCL8
33 response to molecule of bacterial origin GO:0002237 9.66 CXCL8 IL10
34 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.65 IL18 IL1B
35 immune response GO:0006955 9.65 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
36 interleukin-6 production GO:0032635 9.63 IL18 IL1B
37 positive regulation of neuroinflammatory response GO:0150078 9.63 IL18 IL1B IL6
38 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.61 IL18 IL1B
39 type 2 immune response GO:0042092 9.61 IL10 IL18
40 cytokine-mediated signaling pathway GO:0019221 9.28 CCL2 CCL5 CXCL8 FCER2 IL10 IL18
41 negative regulation of cell proliferation GO:0008285 10.02 CXCL8 IL10 IL1B IL6 SOD2

Molecular functions related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL5 CXCL8
2 cytokine activity GO:0005125 9.17 CCL2 CCL5 CXCL8 IL10 IL18 IL1B

Sources for Extrinsic Allergic Alveolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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