MCID: EXT034
MIFTS: 56

Extrinsic Allergic Alveolitis

Categories: Rare diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Extrinsic Allergic Alveolitis

MalaCards integrated aliases for Extrinsic Allergic Alveolitis:

Name: Extrinsic Allergic Alveolitis 12 37 15 73
Alveolitis, Extrinsic Allergic 76 53 44
Hypersensitivity Pneumonitis 12 53 63
Alveolitis 12 55 73
Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis 53
Allergic Interstitial Pneumonitis 53
Pneumonitis Hypersensitivity 55
Allergic Pneumonitis 53
Hp 53

Classifications:



External Ids:

Disease Ontology 12 DOID:841
ICD10 33 J67.9 J67 J67.8
ICD9CM 35 495 495.9
MeSH 44 D000542
NCIt 50 C34369
KEGG 37 H00346

Summaries for Extrinsic Allergic Alveolitis

PubMed Health : 63 About hypersensitivity pneumonitis: Hypersensitivity pneumonitis (noo-mo-NI-tis), or HP, is a disease in which the lungs become inflamed from breathing in foreign substances, such as molds, dusts, and chemicals. These substances also are known as antigens (AN-tih-jens).People are exposed to antigens at home, while at work, and in other settings. However, most people who breathe in these substances don't develop HP.

MalaCards based summary : Extrinsic Allergic Alveolitis, also known as alveolitis, extrinsic allergic, is related to cork-handlers' disease and farmer's lung, and has symptoms including hemoptysis An important gene associated with Extrinsic Allergic Alveolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Pirfenidone and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

Wikipedia : 76 Hypersensitivity pneumonitis (HP; also called allergic alveolitis, bagpipe lung, or extrinsic allergic... more...

Related Diseases for Extrinsic Allergic Alveolitis

Diseases related to Extrinsic Allergic Alveolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)
# Related Disease Score Top Affiliating Genes
1 cork-handlers' disease 33.1 ALB CD79A
2 farmer's lung 33.0 CD79A PI3
3 bagassosis 33.0 CXCL8 IL1B IL6
4 endometrial disease 32.3 CXCL8 IL1B IL6
5 crohn's disease 32.0 IL10 IL1B IL6
6 bronchopneumonia 31.8 CD79A MPO PI3
7 mastitis 31.3 ALB CCL5 CXCL8 IL6
8 hemophagocytic lymphohistiocytosis 31.1 CXCL8 IL10 IL2RA
9 vascular disease 31.0 ALB CCL2 IL6 MPO
10 aspergillosis 30.5 CD79A IL10 SFTPD
11 celiac disease 1 30.5 ALB CD79A IL10
12 pulmonary fibrosis 30.2 CCL2 IL1B SFTPD
13 trypanosomiasis 29.9 ALB CCL2 CCL5 CXCL8 IL10 IL1B
14 arthritis 29.7 CCL2 CXCL8 IL10 IL1B IL6
15 malaria 29.3 ALB CCL2 CCL5 CXCL8 CXCR3 IL10
16 pulmonary fibrosis, idiopathic 28.1 CCL2 CCL5 CXCL8 CXCR3 IL1B SFTPD
17 interstitial lung disease 27.9 CCL2 CCL5 CXCL8 IL10 IL1B IL6
18 lung disease 27.4 CCL2 CCL5 CXCL8 IL10 IL1B MPO
19 pulmonary sarcoidosis 27.3 CCL2 CCL5 CXCR3 IL2RA SFTPD
20 pneumonia 26.9 CCL2 CCL5 CXCL8 IL10 IL1B IL6
21 asthma 25.7 CCL2 CCL5 CD79A CXCL8 FCER2 IL10
22 hantavirus pulmonary syndrome 12.0
23 house allergic alveolitis 11.9
24 hermansky-pudlak syndrome 11.8
25 pancreatitis, hereditary 11.7
26 bird fancier's lung 11.6
27 hepatopulmonary syndrome 11.4
28 malt worker's lung 11.4
29 mushroom workers' lung 11.4
30 pulmonary tuberculosis 11.3
31 hypersensitivity pneumonitis, familial 11.2
32 ventilation pneumonitis 11.2
33 sick building syndrome 11.2
34 maple bark strippers' lung 11.2
35 hermansky-pudlak syndrome 2 11.2
36 anhaptoglobinemia 11.1
37 plasmodium falciparum malaria 11.0
38 paroxysmal nocturnal hemoglobinuria 11.0
39 hellp syndrome 11.0
40 hemoglobinuria 11.0
41 hermansky-pudlak syndrome 1 10.9
42 hermansky-pudlak syndrome 5 10.9
43 exudative glomerulonephritis 10.9 CD79A CXCL8
44 anemia, autoimmune hemolytic 10.9
45 hemochromatosis, type 1 10.9
46 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.9
47 alpha-thalassemia 10.9
48 congenital disorder of glycosylation, type in 10.9
49 coronary artery anomaly 10.9
50 hemolytic anemia 10.9

Comorbidity relations with Extrinsic Allergic Alveolitis via Phenotypic Disease Network (PDN):


Heart Disease Postinflammatory Pulmonary Fibrosis

Graphical network of the top 20 diseases related to Extrinsic Allergic Alveolitis:



Diseases related to Extrinsic Allergic Alveolitis

Symptoms & Phenotypes for Extrinsic Allergic Alveolitis

UMLS symptoms related to Extrinsic Allergic Alveolitis:


hemoptysis

MGI Mouse Phenotypes related to Extrinsic Allergic Alveolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 IL10 IL1B IL2RA IL6 MPO CCL5
2 homeostasis/metabolism MP:0005376 9.9 FCER2 IL10 IL1B IL2RA ALB IL6
3 immune system MP:0005387 9.73 IL10 IL1B IL2RA IL6 CCL2 MPO
4 neoplasm MP:0002006 9.17 IL10 IL1B ALB IL6 CD79A SOD2

Drugs & Therapeutics for Extrinsic Allergic Alveolitis

PubMedHealth treatment related to Extrinsic Allergic Alveolitis: 63

The best way to treat hypersensitivity pneumonitis (HP) is to avoid the antigen that caused it. (An antigen is a substance that your body reacts against, such as molds, dusts, and chemicals.)In acute (short-term) HP, symptoms usually go away once you're no longer in contact with the antigen. In chronic (ongoing) HP, you may need medicines to relieve your symptoms.People who have chronic HP may develop pulmonary fibrosis. This is a condition in which tissue deep in your lungs becomes scarred over time. People who have this condition may need further treatment, such as oxygen therapy and pulmonary rehabilitation (rehab).

Drugs for Extrinsic Allergic Alveolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 2, Phase 3,Not Applicable 53179-13-8 40632
2
Azathioprine Approved Phase 2, Phase 3 446-86-6 2265
3
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
4 Analgesics Phase 2, Phase 3,Not Applicable
5 glucocorticoids Phase 2, Phase 3
6 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
7 Hormone Antagonists Phase 2, Phase 3
8 Hormones Phase 2, Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
10 Peripheral Nervous System Agents Phase 2, Phase 3,Not Applicable
11 Immunosuppressive Agents Phase 2, Phase 3
12 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
13 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Not Applicable
14 Antirheumatic Agents Phase 2, Phase 3,Not Applicable
15 Antimetabolites Phase 2, Phase 3
16 Antimetabolites, Antineoplastic Phase 2, Phase 3
17 Antineoplastic Agents, Hormonal Phase 2, Phase 3
18
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
19
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
20 Autonomic Agents Phase 2,Not Applicable
21 Prednisolone acetate Phase 2
22 Methylprednisolone acetate Phase 2
23 Methylprednisolone Hemisuccinate Phase 2
24 Gastrointestinal Agents Phase 2
25 Neuroprotective Agents Phase 2
26 Prednisolone hemisuccinate Phase 2
27 Prednisolone phosphate Phase 2
28 Antiemetics Phase 2
29 Protective Agents Phase 2
30
Heparin Approved, Investigational 9005-49-6 772 46507594
31 Pepsin A
32 Respiratory System Agents Not Applicable
33 Adrenergic Agents Not Applicable
34 Adrenergic Agonists Not Applicable
35 Adrenergic beta-2 Receptor Agonists Not Applicable
36 Adrenergic beta-Agonists Not Applicable
37 Albuterol Not Applicable
38 Neurotransmitter Agents Not Applicable
39 Tocolytic Agents Not Applicable
40 Anti-Asthmatic Agents Not Applicable
41 Antibodies Not Applicable
42 Immunoglobulins Not Applicable
43 Bronchodilator Agents Not Applicable
44 calcium heparin
45 Pharmaceutical Solutions

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Pirfenidone in the Chronic Hypersensitivity Pneumonitis Treatment Unknown status NCT02496182 Phase 2, Phase 3 Placebo;Pirfenidone;Pirfenidone
2 Stop Exogenous Allergic Alveolitis (EAA) in Childhood Suspended NCT02631603 Phase 2 Placebo;Prednisolone
3 The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis Unknown status NCT01714934
4 Small Airway Involvement in Patients With Chronic Hypersensitivity Pneumonitis Completed NCT02523833 Not Applicable Salbutamol
5 Bronchoalveolar Immune Response Determination Completed NCT01237145
6 Wind Instruments' Fungal Contamination Completed NCT01487850 Not Applicable
7 Work-related Respiratory Symptoms in Champagne Vineyard Workers Completed NCT02883920
8 Explorative Study on the Molecular Pathology of Lung Fibrosis by Combination of Clinical Assessment and System Biology Completed NCT01687946
9 Supplemental Oxygen in Pulmonary Fibrosis Completed NCT01961362
10 Study of Efficacy and Safety of Pirfenidone in Patients With Fibrotic Hypersensitivity Pneumonitis Recruiting NCT02958917 Not Applicable Pirfenidone
11 Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung Recruiting NCT03056404 Not Applicable
12 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
13 Toward Self-management in ILD Recruiting NCT03300583
14 Pulmonary Fibrosis Contact Registry Recruiting NCT01935726
15 Lung MRI in the Management of Idiopathic Pulmonary Fibrosis Recruiting NCT03078426 Not Applicable
16 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416
17 Pulmonary Hypertension in Hypersensitivity Pneumonitis Enrolling by invitation NCT03030807

Search NIH Clinical Center for Extrinsic Allergic Alveolitis

Cochrane evidence based reviews: alveolitis, extrinsic allergic

Genetic Tests for Extrinsic Allergic Alveolitis

Anatomical Context for Extrinsic Allergic Alveolitis

MalaCards organs/tissues related to Extrinsic Allergic Alveolitis:

41
Lung, Testes, Monocytes, Neutrophil, T Cells, Myeloid, Skin

Publications for Extrinsic Allergic Alveolitis

Articles related to Extrinsic Allergic Alveolitis:

(show top 50) (show all 163)
# Title Authors Year
1
Relationship between obstructive sleep apnea syndrome and metabolic syndrome in a patient with chronic extrinsic allergic alveolitis. ( 29542906 )
2016
2
Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis). ( 25914724 )
2015
3
Influence of age on manifestation, VC and TLCO values and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis: Fibrotic response as a hallmark of aging? ( 24406019 )
2014
4
PAR-2, IL-4R, TGF-I^ and TNF-I+ in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis. ( 25009615 )
2014
5
Hypersensitivity pneumonitis (extrinsic allergic alveolitis): A Canadian historical perspective. ( 25299221 )
2014
6
Linear and nonlinear analysis of base lung sound in extrinsic allergic alveolitis patients in comparison to healthy subjects. ( 23591730 )
2013
7
Role of interleukin 4 and its receptor in clinical presentation of chronic extrinsic allergic alveolitis: a pilot study. ( 23721656 )
2013
8
Extrinsic allergic alveolitis as an uncommon diagnostic pitfall in lung cytology. ( 21656702 )
2012
9
Surfactant protein A in chronic extrinsic allergic alveolitis. ( 22654012 )
2012
10
New occupational and environmental causes of asthma and extrinsic allergic alveolitis. ( 23153603 )
2012
11
Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: serological methods in EAA. ( 21924863 )
2011
12
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. ( 21704503 )
2011
13
Acute life-threatening extrinsic allergic alveolitis in a paint controller. ( 21824996 )
2011
14
Angiogenic activity of sera from extrinsic allergic alveolitis patients in relation to clinical, radiological, and functional pulmonary changes. ( 20607270 )
2010
15
Clinical features and prognosis in 21 patients with extrinsic allergic alveolitis. ( 20120765 )
2009
16
Extrinsic allergic alveolitis with an atypical immune expression. ( 19280076 )
2009
17
Extrinsic allergic alveolitis with eosinophil infiltration induced by 1,1,1,2-tetrafluoroethane (HFC-134a): a case report. ( 17827848 )
2007
18
Extrinsic allergic alveolitis: incidence and mortality in the general population. ( 17307752 )
2007
19
An unusual case of an acquired acral partial lipodystrophy (Barraquer-Simons syndrome) in a patient with extrinsic allergic alveolitis. ( 16716174 )
2006
20
Extrinsic allergic alveolitis: comparative study of the bronchoalveolar lavage profiles and radiological presentation. ( 16954458 )
2006
21
Extrinsic allergic alveolitis. ( 16635083 )
2006
22
Involvement of eicosanoids and surfactant protein D in extrinsic allergic alveolitis. ( 16319337 )
2005
23
Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis. ( 15753634 )
2005
24
Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis - another piece in the puzzle? ( 15753631 )
2005
25
Extrinsic allergic alveolitis caused by misting fountains. ( 15950134 )
2005
26
Extrinsic allergic alveolitis (hypersensitivity pneumonitis) caused by Sphingobacterium spiritivorum from the water reservoir of a steam iron. ( 16145174 )
2005
27
Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis. ( 15653992 )
2005
28
Extrinsic allergic alveolitis in practice. ( 15114816 )
2004
29
Extrinsic allergic alveolitis with IgA deficiency. ( 15689306 )
2004
30
[Preliminary study on effect of pentoxifylline in treatment of extrinsic allergic alveolitis]. ( 15061967 )
2004
31
Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages. ( 14989392 )
2004
32
The HRCT features of extrinsic allergic alveolitis. ( 16088561 )
2003
33
Blood myeloid and lymphoid dendritic cells reflect Th1/Th2 balance in sarcoidosis and extrinsic allergic alveolitis. ( 15314973 )
2003
34
Extrinsic allergic alveolitis induced by the yeast Debaryomyces hansenii. ( 12449192 )
2002
35
[Biochemical characteristics of fluid and cells of bronchoalveolar washings in patients with extrinsic allergic alveolitis]. ( 12474462 )
2002
36
IgG antibodies typical for extrinsic allergic alveolitis--an inter-laboratory quality assessment. ( 11726311 )
2001
37
Respiratory syndrome very similar to extrinsic allergic alveolitis due to Penicillium verrucosum in workers in a cheese factory. ( 11307594 )
2001
38
Sulfasalazine-induced extrinsic allergic alveolitis in a patient with psoriatic arthritis. ( 11726310 )
2001
39
Extrinsic allergic alveolitis from a proteolytic enzyme. ( 11345286 )
2001
40
Histologically proven extrinsic allergic alveolitis with severe obstructive pulmonary emphysema ( 10756171 )
2000
41
Pet-fish food lung- a new form of extrinsic allergic alveolitis. ( 10756166 )
2000
42
Extrinsic allergic alveolitis in domestic environments (Domestic allergic alveolitis) caused by mouldy tapestry ( 10756168 )
2000
43
Extrinsic allergic alveolitis caused by cabreuva wood dust. ( 11031353 )
2000
44
A family with extrinsic allergic alveolitis caused by wild city pigeons: A case report. ( 10799626 )
2000
45
Effects of erythromycin on experimental extrinsic allergic alveolitis. ( 10051731 )
1999
46
BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. ( 10704058 )
1999
47
Aerobiological analysis in a salami factory: a possible case of extrinsic allergic alveolitis by Penicillium camembertii. ( 10421864 )
1999
48
Mucosal immunity in extrinsic allergic alveolitis: salivary immunoglobulins and antibody against inhaled avian antigens among pigeon breeders. ( 10383597 )
1999
49
Elevated levels of soluble TNF receptors in bronchoalveolar lavage fluid in extrinsic allergic alveolitis. ( 10469029 )
1999
50
BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. ( 9705608 )
1998

Variations for Extrinsic Allergic Alveolitis

Expression for Extrinsic Allergic Alveolitis

Search GEO for disease gene expression data for Extrinsic Allergic Alveolitis.

Pathways for Extrinsic Allergic Alveolitis

Pathways related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CCL2 CCL5 CD79A CXCL8 FCER2 IL10
2
Show member pathways
13.52 CCL2 CCL5 CXCL8 CXCR3 FCER2 IL10
3
Show member pathways
13.46 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
4
Show member pathways
13.35 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B
5
Show member pathways
13.27 CCL2 CCL5 CXCL8 FCER2 IL10 IL1B
6
Show member pathways
13.18 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B
7
Show member pathways
12.89 CCL2 CCL5 CXCL8 IL10 IL1B IL6
8
Show member pathways
12.83 CXCL8 IL10 IL1B IL2RA IL6
9
Show member pathways
12.73 CCL2 CCL5 CXCL8 IL1B IL2RA IL6
10
Show member pathways
12.61 CXCL8 IL10 IL1B IL2RA IL6
11
Show member pathways
12.59 CCL2 IL10 IL1B IL6 MPO
12 12.43 CCL2 CCL5 CD79A IL10 IL1B IL2RA
13
Show member pathways
12.41 IL10 IL1B IL2RA IL6
14
Show member pathways
12.31 CCL2 CXCL8 IL1B IL6
15
Show member pathways
12.18 CXCL8 IL1B IL6 SFTPD
16 12.17 CXCL8 IL10 IL1B IL6
17 12 CCL2 CXCL8 IL1B IL6
18
Show member pathways
11.98 CCL2 CCL5 CXCL8 CXCR3
19
Show member pathways
11.96 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
20 11.94 CCL2 CCL5 IL1B IL6
21 11.92 CD79A IL10 IL2RA IL6 MPO
22 11.89 CXCL8 IL1B IL6
23 11.89 CCL2 CXCL8 IL1B IL6
24 11.87 FCER2 IL1B IL2RA IL6
25 11.86 CXCL8 IL10 IL1B IL6
26
Show member pathways
11.83 ALB CCL2 CCL5 IL1B IL6 MPO
27 11.8 CXCL8 IL1B IL6
28 11.79 CCL2 CCL5 CXCL8 IL1B IL6
29 11.75 CXCR3 IL10 IL1B IL2RA
30 11.73 IL10 IL1B IL6
31 11.71 CXCL8 IL10 IL1B IL6
32 11.69 CCL2 CXCL8 FCER2 IL10 IL1B IL6
33
Show member pathways
11.65 CXCL8 IL1B IL6
34 11.59 CXCL8 IL1B IL6
35 11.52 CCL2 CCL5 CXCL8 IL1B IL6
36 11.51 CXCL8 IL2RA IL6
37 11.37 IL10 IL1B IL6
38 11.37 IL10 IL1B IL6
39 11.36 CCL5 IL1B IL6
40 11.35 CCL2 CXCL8 IL6
41 11.34 CCL2 CXCL8 IL10 IL1B IL6
42 11.28 IL10 IL1B IL6
43 10.97 CXCL8 IL6
44 10.92 CCL2 IL1B MPO
45 10.86 CCL2 CCL5 CXCL8 FCER2 IL10 IL1B

GO Terms for Extrinsic Allergic Alveolitis

Cellular components related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ALB CCL2 CCL5 CXCL8 IL10 IL1B
2 external side of plasma membrane GO:0009897 9.46 CD79A CXCR3 FCER2 IL2RA
3 extracellular region GO:0005576 9.36 ALB CCL2 CCL5 CXCL8 FCER2 IL10

Biological processes related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.96 CXCL8 IL10 IL1B IL6 SOD2
2 cell surface receptor signaling pathway GO:0007166 9.91 CCL2 CD79A CXCR3 IL2RA
3 regulation of signaling receptor activity GO:0010469 9.91 CCL2 CCL5 CXCL8 IL10 IL1B IL6
4 MAPK cascade GO:0000165 9.89 CCL2 CCL5 IL1B IL2RA
5 response to lipopolysaccharide GO:0032496 9.87 CXCL8 IL10 IL1B MPO
6 chemotaxis GO:0006935 9.84 CCL2 CCL5 CXCL8 CXCR3
7 cellular response to tumor necrosis factor GO:0071356 9.83 CCL2 CCL5 CXCL8
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 IL10 IL1B IL6
9 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL8 IL10 IL6
10 cellular response to interleukin-1 GO:0071347 9.76 CCL2 CCL5 CXCL8
11 cellular response to organic cyclic compound GO:0071407 9.75 CCL2 CCL5 IL1B
12 protein kinase B signaling GO:0043491 9.72 CCL2 CCL5 IL1B
13 chemokine-mediated signaling pathway GO:0070098 9.71 CCL2 CCL5 CXCL8 CXCR3
14 monocyte chemotaxis GO:0002548 9.7 CCL2 CCL5 IL6
15 immune response GO:0006955 9.7 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
16 negative regulation of T cell proliferation GO:0042130 9.69 IL10 IL2RA SFTPD
17 neutrophil chemotaxis GO:0030593 9.67 CCL2 CCL5 CXCL8 IL1B
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 CCL2 FCER2
19 cellular response to fibroblast growth factor stimulus GO:0044344 9.65 CCL2 CCL5 CXCL8
20 negative regulation of growth of symbiont in host GO:0044130 9.64 IL10 MPO
21 inflammatory response to antigenic stimulus GO:0002437 9.64 IL1B IL2RA
22 removal of superoxide radicals GO:0019430 9.63 MPO SOD2
23 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 CCL2 CCL5 IL1B
25 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.62 CCL5 CXCL8
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 IL1B
27 PERK-mediated unfolded protein response GO:0036499 9.61 CCL2 CXCL8
28 neutrophil activation GO:0042119 9.6 CCL5 CXCL8
29 positive regulation of T cell proliferation GO:0042102 9.56 CCL5 IL1B IL2RA IL6
30 inflammatory response GO:0006954 9.56 CCL2 CCL5 CXCL8 CXCR3 IL10 IL1B
31 macrophage chemotaxis GO:0048246 9.5 CCL2 CCL5 SFTPD
32 cytokine-mediated signaling pathway GO:0019221 9.23 CCL2 CCL5 CXCL8 FCER2 IL10 IL1B

Molecular functions related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CCL2 CCL5 CXCL8
2 cytokine activity GO:0005125 9.1 CCL2 CCL5 CXCL8 IL10 IL1B IL6

Sources for Extrinsic Allergic Alveolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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