MCID: EXT034
MIFTS: 58

Extrinsic Allergic Alveolitis

Categories: Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Extrinsic Allergic Alveolitis

MalaCards integrated aliases for Extrinsic Allergic Alveolitis:

Name: Extrinsic Allergic Alveolitis 12 38 15 17 74
Alveolitis 12 56 15 74
Alveolitis, Extrinsic Allergic 77 54 45
Hypersensitivity Pneumonitis 12 54 64
Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis 54
Allergic Interstitial Pneumonitis 54
Pneumonitis Hypersensitivity 56
Allergic Pneumonitis 54
Hp 54

Classifications:



External Ids:

Disease Ontology 12 DOID:841
KEGG 38 H00346
ICD9CM 36 495 495.9
MeSH 45 D000542
NCIt 51 C34369
SNOMED-CT 69 37471005
ICD10 34 J67 J67.8 J67.9

Summaries for Extrinsic Allergic Alveolitis

PubMed Health : 64 About hypersensitivity pneumonitis: Hypersensitivity pneumonitis (noo-mo-NI-tis), or HP, is a disease in which the lungs become inflamed from breathing in foreign substances, such as molds, dusts, and chemicals. These substances also are known as antigens (AN-tih-jens).People are exposed to antigens at home, while at work, and in other settings. However, most people who breathe in these substances don't develop HP.

MalaCards based summary : Extrinsic Allergic Alveolitis, also known as alveolitis, is related to bagassosis and endometrial disease, and has symptoms including hemoptysis An important gene associated with Extrinsic Allergic Alveolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisone and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and prostate, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

Wikipedia : 77 Hypersensitivity pneumonitis (HP) is an inflammation of the alveoli within the lung caused by... more...

Related Diseases for Extrinsic Allergic Alveolitis

Diseases related to Extrinsic Allergic Alveolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 498)
# Related Disease Score Top Affiliating Genes
1 bagassosis 32.7 CXCL8 IL1B IL6
2 endometrial disease 32.0 CXCL8 IL1B IL6
3 heart disease 32.0 ALB CXCL8 IL10 IL1B IL6
4 mastitis 31.7 ALB CCL5 CXCL8 IL6
5 parasitic protozoa infectious disease 31.7 IL10 IL1B IL6
6 idiopathic interstitial pneumonia 31.6 CCL2 CXCL8 SFTPD
7 trypanosomiasis 31.3 ALB CCL2 CCL5 CXCL8 IL10 IL1B
8 malaria 31.2 ALB CCL2 CCL5 CXCL8 CXCR3 IL10
9 tropical spastic paraparesis 31.1 CCL5 CXCR3 IL10 IL2RA IL6
10 vascular disease 30.9 ALB CCL2 IL6 MPO
11 pulmonary fibrosis 30.7 CCL2 IL1B SFTPD
12 allergic hypersensitivity disease 30.6 CCL5 FCER2 IL10
13 sarcoidosis 1 30.6 CXCR3 IL1B IL2RA
14 sleep apnea 30.5 CXCL8 IL1B IL6
15 burns 30.4 ALB IL1B
16 helicobacter pylori infection 30.4 CCL5 CXCL8 IL1B
17 diabetic foot ulcers 30.2 CCL2 IL6
18 ulcerative colitis 30.1 CXCL8 IL10 IL1B IL6 MPO
19 transverse myelitis 30.1 CXCL8 IL10 IL6
20 hemorrhagic fever with renal syndrome 30.1 ALB CXCL8 IL6
21 pulpitis 30.1 CXCL8 IL1B IL6
22 respiratory failure 30.1 ALB CXCL8 SFTPD
23 bronchiolitis 30.1 CCL5 CXCL8 IL10 IL6
24 arthritis 30.1 CCL2 CXCL8 IL10 IL1B IL6
25 adult respiratory distress syndrome 30.0 CXCL8 IL10 IL6
26 bronchiolitis obliterans 30.0 CXCL8 CXCR3 IL10 IL6
27 gingivitis 30.0 CXCL8 IL1B IL6
28 pulmonary edema 30.0 CXCL8 IL10 IL1B
29 bronchitis 29.9 ALB CXCL8 MPO
30 osteomyelitis 29.9 CXCL8 IL10 IL1B IL6
31 toxoplasmosis 29.9 IL10 IL1B IL6
32 acute respiratory distress syndrome 29.9 CXCL8 IL1B IL6 PI3 SFTPD
33 chronic graft versus host disease 29.9 ALB IL10 IL2RA
34 graft-versus-host disease 29.9 IL10 IL1B IL6
35 human immunodeficiency virus infectious disease 29.9 CCL5 IL10 IL6
36 juvenile rheumatoid arthritis 29.8 IL1B IL2RA IL6
37 stachybotrys chartarum 29.8 CCL2 CCL5 IL1B IL6
38 colitis 29.8 CXCL8 IL10 IL1B IL6 MPO
39 silicosis 29.6 CCL2 CXCL8 IL1B SFTPD
40 glomerulonephritis 29.6 ALB CCL2 IL1B MPO
41 bone inflammation disease 29.6 CCL2 CXCL8 IL10 IL1B IL6
42 diabetes mellitus 29.5 ALB IL1B IL2RA IL6 SOD2
43 periodontitis 29.5 CCL2 CXCL8 IL10 IL1B IL6
44 end stage renal failure 29.5 ALB FN1 IL6
45 uveitis 29.4 CCL2 CXCR3 IL10 IL2RA
46 myeloma, multiple 29.4 ALB CXCL8 FN1 IL6
47 nonspecific interstitial pneumonia 29.4 CCL2 CXCL5 CXCR3
48 interstitial lung disease 29.4 CCL2 CCL5 CXCL8 IL10 IL1B IL6
49 pneumonia 29.3 CCL2 CCL5 CXCL8 IL10 IL1B IL6
50 pulmonary fibrosis, idiopathic 29.1 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL1B

Comorbidity relations with Extrinsic Allergic Alveolitis via Phenotypic Disease Network (PDN):


Heart Disease Postinflammatory Pulmonary Fibrosis

Graphical network of the top 20 diseases related to Extrinsic Allergic Alveolitis:



Diseases related to Extrinsic Allergic Alveolitis

Symptoms & Phenotypes for Extrinsic Allergic Alveolitis

UMLS symptoms related to Extrinsic Allergic Alveolitis:


hemoptysis

MGI Mouse Phenotypes related to Extrinsic Allergic Alveolitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 CCL5 CXCR3 FCER2 FN1 IL10 IL1B
2 homeostasis/metabolism MP:0005376 10 ALB CXCR3 FCER2 FN1 IL10 IL1B
3 immune system MP:0005387 9.93 CCL2 CCL5 CXCR3 FCER2 FN1 IL10
4 mortality/aging MP:0010768 9.7 ALB CXCR3 FCER2 FN1 IL10 IL1B
5 neoplasm MP:0002006 9.17 ALB CXCR3 FN1 IL10 IL1B IL6

Drugs & Therapeutics for Extrinsic Allergic Alveolitis

PubMedHealth treatment related to Extrinsic Allergic Alveolitis: 64

The best way to treat hypersensitivity pneumonitis (HP) is to avoid the antigen that caused it. (An antigen is a substance that your body reacts against, such as molds, dusts, and chemicals.)In acute (short-term) HP, symptoms usually go away once you're no longer in contact with the antigen. In chronic (ongoing) HP, you may need medicines to relieve your symptoms.People who have chronic HP may develop pulmonary fibrosis. This is a condition in which tissue deep in your lungs becomes scarred over time. People who have this condition may need further treatment, such as oxygen therapy and pulmonary rehabilitation (rehab).

Drugs for Extrinsic Allergic Alveolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
2
Azathioprine Approved Phase 2, Phase 3 446-86-6 2265
3
Pirfenidone Approved, Investigational Phase 2, Phase 3,Not Applicable 53179-13-8 40632
4 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
5 Immunologic Factors Phase 2, Phase 3
6 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
7 Antimetabolites, Antineoplastic Phase 2, Phase 3
8 Antirheumatic Agents Phase 2, Phase 3,Not Applicable
9 Analgesics Phase 2, Phase 3,Not Applicable
10 Immunosuppressive Agents Phase 2, Phase 3
11 Antineoplastic Agents, Hormonal Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3,Not Applicable
13 glucocorticoids Phase 2, Phase 3
14 Antimetabolites Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Not Applicable
18 Hormone Antagonists Phase 2, Phase 3
19
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
20
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
21
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
22
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
23
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
24 Autonomic Agents Phase 2,Not Applicable
25 Prednisolone acetate Phase 2
26 Antiemetics Phase 2
27 Protective Agents Phase 2
28 Methylprednisolone Acetate Phase 2
29 Gastrointestinal Agents Phase 2
30 Neuroprotective Agents Phase 2
31
Heparin Approved, Investigational 9005-49-6 46507594 772
32
Lidocaine Approved, Vet_approved 137-58-6 3676
33 Pharmaceutical Solutions
34 calcium heparin
35 Pepsin A
36 Bronchodilator Agents Not Applicable
37 Adrenergic beta-2 Receptor Agonists Not Applicable
38 Adrenergic Agents Not Applicable
39 Adrenergic Agonists Not Applicable
40 Respiratory System Agents Not Applicable
41 Neurotransmitter Agents Not Applicable
42 Adrenergic beta-Agonists Not Applicable
43 Tocolytic Agents Not Applicable
44 Anti-Asthmatic Agents Not Applicable
45 Albuterol Not Applicable
46 Antibodies Not Applicable
47 Immunoglobulins Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Pirfenidone in the Chronic Hypersensitivity Pneumonitis Treatment Unknown status NCT02496182 Phase 2, Phase 3 Placebo;Pirfenidone;Pirfenidone
2 Stop Exogenous Allergic Alveolitis (EAA) in Childhood Suspended NCT02631603 Phase 2 Placebo;Prednisolone
3 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
4 The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis Unknown status NCT01714934
5 Lung MRI in the Management of Idiopathic Pulmonary Fibrosis Unknown status NCT03078426 Not Applicable
6 Small Airway Involvement in Patients With Chronic Hypersensitivity Pneumonitis Completed NCT02523833 Not Applicable Salbutamol
7 Bronchoalveolar Immune Response Determination Completed NCT01237145
8 Wind Instruments' Fungal Contamination Completed NCT01487850 Not Applicable
9 Work-related Respiratory Symptoms in Champagne Vineyard Workers Completed NCT02883920
10 Explorative Study on the Molecular Pathology of Lung Fibrosis by Combination of Clinical Assessment and System Biology Completed NCT01687946
11 Supplemental Oxygen in Pulmonary Fibrosis Completed NCT01961362
12 Pulmonary Fibrosis Contact Registry Completed NCT01935726
13 Immune Response in Hypersensitivity Pneumonitis Recruiting NCT03873649
14 Study of Efficacy and Safety of Pirfenidone in Patients With Fibrotic Hypersensitivity Pneumonitis Recruiting NCT02958917 Not Applicable Pirfenidone
15 Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung Recruiting NCT03056404 Not Applicable
16 BPF Genetics of ILD Study Recruiting NCT03747627
17 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
18 Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry Recruiting NCT01915511
19 Toward Self-management in ILD Recruiting NCT03300583
20 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416
21 Pulmonary Hypertension in Hypersensitivity Pneumonitis Enrolling by invitation NCT03030807
22 Skeletal Muscle Function in Interstitial Lung Disease Not yet recruiting NCT03800017 Not Applicable

Search NIH Clinical Center for Extrinsic Allergic Alveolitis

Cochrane evidence based reviews: alveolitis, extrinsic allergic

Genetic Tests for Extrinsic Allergic Alveolitis

Anatomical Context for Extrinsic Allergic Alveolitis

MalaCards organs/tissues related to Extrinsic Allergic Alveolitis:

42
Lung, Neutrophil, Prostate, T Cells, Liver, Heart, Monocytes

Publications for Extrinsic Allergic Alveolitis

Articles related to Extrinsic Allergic Alveolitis:

(show top 50) (show all 921)
# Title Authors Year
1
Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients. ( 30911386 )
2019
2
NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis. ( 30760244 )
2019
3
Association Between Pulmonary Vessel-Related Structures and Cryptogenic Fibrosing Alveolitis Using Derived Computed Tomography Among Chinese Patients. ( 30927543 )
2019
4
Radiation Pneumonitis with Eosinophilic Alveolitis in a Lung Cancer Patient. ( 29279483 )
2018
5
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. ( 29723658 )
2018
6
Hypersensitivity pneumonitis: A fibrosing alveolitis produced by inhalation of diverse antigens. ( 30448501 )
2018
7
4 and 6 interleukin's action in the pathogenesis of periodontitis, gingivitis and dental alveolitis. ( 29203739 )
2017
8
The diagnostic importance of the bronchoalveolar lavage in lymphocytic alveolitis. ( 27471881 )
2017
9
Differences in Texture Analysis Parameters Between Active Alveolitis and Lung Fibrosis in Chest CT of Patients with Systemic Sclerosis: A Feasibility Study. ( 28807589 )
2017
10
Relationship between obstructive sleep apnea syndrome and metabolic syndrome in a patient with chronic extrinsic allergic alveolitis. ( 29542906 )
2016
11
Eosinophil alveolitis in two patients with idiopathic pulmonary fibrosis. ( 27625983 )
2016
12
Diagnostic Value of the CD103+CD4+/CD4+ Ratio to Differentiate Sarcoidosis from Other Causes of Lymphocytic Alveolitis. ( 27230039 )
2016
13
Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis. ( 27591866 )
2016
14
HIV Suppression Restores the Lung Mucosal CD4+ T-Cell Viral Immune Response and Resolves CD8+ T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease. ( 27613775 )
2016
15
Neutrophilic Alveolitis and High Serum Pro-Brain Natriuretic Peptide Level may be Indicators of Pulmonary Functional Impairment in Connective Tissue Disorders. ( 29900993 )
2016
16
Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis. ( 24406019 )
2015
17
Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis). ( 25914724 )
2015
18
Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. ( 25536276 )
2015
19
Can serial PEF measurements separate occupational asthma from allergic alveolitis? ( 25825508 )
2015
20
Migratory eosinophilic alveolitis caused by radiation therapy. ( 26101656 )
2015
21
Serial peak flow measurements in allergic alveolitis. ( 26240129 )
2015
22
Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis. ( 26469087 )
2015
23
Recurrent episodes of hemorrhagic alveolitis in relapsing catastrophic antiphospholipid syndrome: the same side of the dark moon. ( 24362787 )
2014
24
PAR-2, IL-4R, TGF-β and TNF-α in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis. ( 25009615 )
2014
25
Hypersensitivity pneumonitis (extrinsic allergic alveolitis): a Canadian historical perspective. ( 25299221 )
2014
26
Lesson of the month: extrinsic allergic (bronchiolo)alveolitis and metal working fluids. ( 25005567 )
2014
27
Linear and nonlinear analysis of base lung sound in extrinsic allergic alveolitis patients in comparison to healthy subjects. ( 23591730 )
2013
28
Role of interleukin 4 and its receptor in clinical presentation of chronic extrinsic allergic alveolitis: a pilot study. ( 23721656 )
2013
29
Acute alveolitis following infliximab therapy for psoriasis. ( 22780696 )
2013
30
High alveolar concentration of nitric oxide is associated with alveolitis in scleroderma. ( 23099297 )
2013
31
Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice. ( 23752613 )
2013
32
Lupus erythematosus cell phenomenon in pediatric bronchoalveolar lavages: possible manifestation of early radioadaptive response in radiation induced alveolitis. ( 23830389 )
2013
33
Extrinsic allergic alveolitis as an uncommon diagnostic pitfall in lung cytology. ( 21656702 )
2012
34
Surfactant protein A in chronic extrinsic allergic alveolitis. ( 22654012 )
2012
35
New occupational and environmental causes of asthma and extrinsic allergic alveolitis. ( 23153603 )
2012
36
Perialveolar bacterial microbiota and bacteraemia after dental alveolitis in adult rats that had been subjected to neonatal malnutrition. ( 21816120 )
2012
37
Lethal hemorrhagic alveolitis after adenovirus pneumonia in a lung transplant recipient. ( 22054722 )
2012
38
Fatal fibrosing alveolitis with certolizumab. ( 22328567 )
2012
39
Pulmonary fibrosis and lymphocytic alveolitis associated with triple antiphospholipid antibody positivity: a diagnostic puzzle. ( 22992328 )
2012
40
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. ( 21704503 )
2011
41
Acute life-threatening extrinsic allergic alveolitis in a paint controller. ( 21824996 )
2011
42
Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: serological methods in EAA. ( 21924863 )
2011
43
Pre-clinical detection of amiodarone-induced acute fibrosing alveolitis by intra-thoracic impedance monitor of an implantable cardioverter-defibrillator. ( 20851824 )
2011
44
NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis. ( 21149496 )
2011
45
Clozapine-induced lymphocytic alveolitis. ( 21297049 )
2011
46
Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse. ( 21342009 )
2011
47
Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing. ( 21625744 )
2011
48
Chronic pulmonary thromboembolism pathologically showing homogeneous cellular alveolitis. ( 21963740 )
2011
49
Toxic alveolitis after inhalation of a water repellent. ( 22002324 )
2011
50
Angiogenic activity of sera from extrinsic allergic alveolitis patients in relation to clinical, radiological, and functional pulmonary changes. ( 20607270 )
2010

Variations for Extrinsic Allergic Alveolitis

Expression for Extrinsic Allergic Alveolitis

Search GEO for disease gene expression data for Extrinsic Allergic Alveolitis.

Pathways for Extrinsic Allergic Alveolitis

Pathways related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL2 CCL5 CXCL8 FCER2 FN1 IL10
2
Show member pathways
13.84 CCL2 CCL5 CXCL5 CXCL8 CXCR3 FN1
3
Show member pathways
13.62 CCL2 CCL5 CXCL5 CXCL8 CXCR3 FCER2
4
Show member pathways
13.49 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
5
Show member pathways
13.4 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
6
Show member pathways
13.34 CCL2 CCL5 CXCL8 FCER2 FN1 IL10
7
Show member pathways
13.28 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
8
Show member pathways
13.1 CCL2 CCL5 CXCL8 IL10 IL1B IL6
9
Show member pathways
12.86 CCL2 CCL5 CXCL5 CXCL8 CXCR3
10
Show member pathways
12.84 CXCL8 IL10 IL1B IL2RA IL6
11
Show member pathways
12.61 CCL2 FN1 IL10 IL1B IL6 MPO
12 12.58 CCL2 CCL5 IL10 IL1B IL2RA MPO
13
Show member pathways
12.55 IL10 IL1B IL2RA IL6
14
Show member pathways
12.36 CCL2 CXCL5 CXCL8 IL1B IL6
15
Show member pathways
12.29 CXCL8 IL10 IL1B IL2RA IL6
16
Show member pathways
12.23 CXCL8 FN1 IL1B IL6 SFTPD
17
Show member pathways
12.23 CCL2 CCL5 CXCL5 CXCL8 CXCR3 FN1
18 12.2 CXCL8 IL10 IL1B IL6
19
Show member pathways
12.2 ALB CCL2 CCL5 IL1B IL6 MPO
20
Show member pathways
12.05 CCL2 CCL5 CXCL8 IL10 IL1B IL2RA
21 12.04 CCL2 CXCL8 IL1B IL6
22
Show member pathways
12.03 CCL2 CCL5 CXCL5 CXCL8 CXCR3
23 12.02 IL10 IL2RA IL6 MPO
24
Show member pathways
11.99 FN1 IL1B IL6
25 11.99 CCL2 CCL5 CXCL5 IL1B IL6
26 11.97 CXCL8 FN1 IL1B IL6
27 11.93 FCER2 IL1B IL2RA IL6
28 11.92 CCL2 CXCL8 FN1 IL1B IL6
29 11.89 CXCL8 FN1 IL10 IL1B IL6
30 11.84 CXCR3 IL10 IL1B IL2RA
31 11.83 IL10 IL2RA IL6
32 11.81 CXCL8 IL1B IL6
33 11.76 CXCL5 CXCL8 IL10 IL1B IL6
34 11.74 IL10 IL1B IL6
35 11.71 CCL2 CCL5 IL10 IL1B IL6
36 11.69 CCL2 CCL5 CXCL5 CXCL8 IL1B IL6
37
Show member pathways
11.67 CXCL8 IL1B IL6
38 11.61 CXCL8 IL1B IL6
39 11.6 CCL2 CCL5 CXCL8 IL1B IL6
40 11.56 CCL2 CXCL8 FCER2 FN1 IL10 IL1B
41 11.55 FN1 IL6 MPO
42 11.54 CXCL8 IL2RA IL6
43 11.46 CCL2 CXCL8 IL10 IL1B IL6
44 11.42 IL10 IL1B IL6
45 11.39 IL10 IL1B IL6
46 11.39 CCL5 IL1B IL6
47 11.37 CCL2 CXCL8 IL6
48 11.29 IL10 IL1B IL6
49 11.09 CXCL8 FN1 IL6
50 11 CCL2 IL1B MPO

GO Terms for Extrinsic Allergic Alveolitis

Cellular components related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ALB CCL2 CCL5 CXCL5 CXCL8 FN1
2 extracellular region GO:0005576 9.44 ALB CCL2 CCL5 CXCL5 CXCL8 FCER2

Biological processes related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 CXCL8 IL10 IL1B IL6 SOD2
2 regulation of signaling receptor activity GO:0010469 9.95 CCL2 CCL5 CXCL5 CXCL8 IL10 IL1B
3 angiogenesis GO:0001525 9.92 CCL2 CXCL8 CXCR3 FN1
4 MAPK cascade GO:0000165 9.91 CCL2 CCL5 IL1B IL2RA
5 cellular protein metabolic process GO:0044267 9.89 ALB FN1 IL6 SFTPD
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 IL10 IL1B IL6
7 chemotaxis GO:0006935 9.83 CCL2 CCL5 CXCL5 CXCL8 CXCR3
8 cellular response to interleukin-1 GO:0071347 9.8 CCL2 CCL5 CXCL8
9 cell chemotaxis GO:0060326 9.8 CCL2 CCL5 CXCL5 CXCR3
10 cellular response to organic cyclic compound GO:0071407 9.79 CCL2 CCL5 IL1B
11 neutrophil chemotaxis GO:0030593 9.77 CCL2 CCL5 CXCL5 CXCL8 IL1B
12 positive regulation of T cell proliferation GO:0042102 9.76 CCL5 IL1B IL2RA IL6
13 inflammatory response GO:0006954 9.76 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
14 monocyte chemotaxis GO:0002548 9.74 CCL2 CCL5 IL6
15 negative regulation of T cell proliferation GO:0042130 9.73 IL10 IL2RA SFTPD
16 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL5 CXCL8 IL10 IL1B IL6
17 protein kinase B signaling GO:0043491 9.72 CCL2 CCL5 IL1B
18 chemokine-mediated signaling pathway GO:0070098 9.72 CCL2 CCL5 CXCL5 CXCL8 CXCR3
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CCL2 CCL5 IL1B
20 cellular response to fibroblast growth factor stimulus GO:0044344 9.7 CCL2 CCL5 CXCL8
21 leukocyte chemotaxis GO:0030595 9.69 CXCL5 CXCL8 IL10
22 positive regulation of glial cell proliferation GO:0060252 9.67 IL1B IL6
23 negative regulation of growth of symbiont in host GO:0044130 9.66 IL10 MPO
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 IL1B
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 CCL2 FCER2
26 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.65 CCL5 CXCL8
27 macrophage chemotaxis GO:0048246 9.65 CCL2 CCL5 SFTPD
28 removal of superoxide radicals GO:0019430 9.64 MPO SOD2
29 PERK-mediated unfolded protein response GO:0036499 9.64 CCL2 CXCL8
30 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10
31 neutrophil activation GO:0042119 9.63 CCL5 CXCL8
32 immune response GO:0006955 9.61 CCL2 CCL5 CXCL5 CXCL8 CXCR3 IL10
33 response to glucocorticoid GO:0051384 9.6 IL10 IL6
34 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B IL6
35 cytokine-mediated signaling pathway GO:0019221 9.28 CCL2 CCL5 CXCL8 FCER2 FN1 IL10

Molecular functions related to Extrinsic Allergic Alveolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 ALB CCL5 CXCL5 FN1 SFTPD SOD2
2 integrin binding GO:0005178 9.43 FCER2 FN1 IL1B
3 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL5 CXCL8
4 cytokine activity GO:0005125 9.1 CCL2 CCL5 CXCL8 IL10 IL1B IL6

Sources for Extrinsic Allergic Alveolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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