MCID: EXT035
MIFTS: 33

Extrinsic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Extrinsic Cardiomyopathy

MalaCards integrated aliases for Extrinsic Cardiomyopathy:

Name: Extrinsic Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3978
ICD9CM 35 425.8
SNOMED-CT 68 195580005
UMLS 73 C0155699

Summaries for Extrinsic Cardiomyopathy

Disease Ontology : 12 A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.

MalaCards based summary : Extrinsic Cardiomyopathy is related to myocarditis and punctate inner choroidopathy. An important gene associated with Extrinsic Cardiomyopathy is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Extrinsic Cardiomyopathy

Diseases related to Extrinsic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.8 CD40LG CXADR IL6 MYH6 TNF TNNI3
2 punctate inner choroidopathy 11.0 IL10 TNF
3 scorpion envenomation 10.9 IL6 TNF
4 loeffler syndrome 10.9 ACE CD40LG
5 tick paralysis 10.9 PIK3C2A TNNI3
6 ross river fever 10.9 CD40LG IL10
7 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
8 leukomalacia 10.8 IL6 TNF
9 staphylococcal toxic shock syndrome 10.8 IL1B TNF
10 vibrio vulnificus infection 10.8 IL6 PIK3C2A
11 recurrent corneal erosion 10.8 IL1B IL6
12 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
13 jejunoileitis 10.8 CD40LG IL1B TNF
14 eye lymphoma 10.8 IL10 IL6 TLR9
15 ocular toxoplasmosis 10.8 CD40LG IL17A TLR9
16 laryngitis 10.7 IL1B IL6 TNF
17 infective endocarditis 10.7 IL6 TNF TNNI3
18 subacute cutaneous lupus erythematosus 10.7 ACE TNF
19 bagassosis 10.7 IL1B IL6
20 acute vascular insufficiency of intestine 10.7 IL1B IL6 TNF
21 trichostrongyloidiasis 10.7 CD40LG PIK3C2A
22 poems syndrome 10.7 IL1B IL6 TNF
23 monoclonal gammopathy of uncertain significance 10.7 CD40LG IL6 TNF
24 rheumatoid lung disease 10.7 CD40LG IL17A TNF
25 churg-strauss syndrome 10.7 CD40LG IL10 TNF
26 meningoencephalitis 10.7 CD40LG IL6 TLR9
27 aseptic meningitis 10.7 IL10 IL1B TNF
28 listeriosis 10.7 IL10 IL6 TNF
29 intermediate uveitis 10.7 IL10 IL6 TNF
30 endometritis 10.7 IL1B IL6 TNF
31 irritable bowel syndrome 10.7 IL10 TLR9 TNF
32 post-transplant lymphoproliferative disease 10.7 IL10 IL6 TNF
33 pulpitis 10.7 IL1B IL6 TNF
34 lymph node disease 10.7 CD40LG IL6 TNF
35 adult-onset still's disease 10.7 IL1B IL6 TNF
36 hematopoietic stem cell transplantation 10.7 IL10 IL6 TNF
37 funisitis 10.7 IL10 IL1B IL6
38 legionnaires' disease 10.7 CD40LG PIK3C2A TLR9
39 viral pneumonia 10.7 IL17A IL6 TLR9
40 placenta disease 10.7 IL1B IL6 TLR9
41 cytomegalovirus infection 10.7 IL10 IL6 TNF
42 posterior urethral valves 10.7 ACE IL6 TNF
43 intrinsic cardiomyopathy 10.7 ACE MYH6 TNNI3
44 zika fever 10.7 CD40LG IFNB1
45 peptic ulcer disease 10.7 IL10 IL1B TNF
46 acute respiratory distress syndrome 10.7 IL1B IL6 TNF
47 ischemic heart disease 10.7 ACE IL6 TNF
48 bacterial vaginosis 10.7 IL1B IL6 TNF
49 tropical endomyocardial fibrosis 10.7 IL10 IL4 TNF
50 skin sarcoidosis 10.7 ACE TNF

Graphical network of the top 20 diseases related to Extrinsic Cardiomyopathy:



Diseases related to Extrinsic Cardiomyopathy

Symptoms & Phenotypes for Extrinsic Cardiomyopathy

MGI Mouse Phenotypes related to Extrinsic Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 IL4 IFNB1 IL10 ACE IL17A CD40LG
2 cardiovascular system MP:0005385 10.26 IL10 ACE CD40LG IL1B CXADR TNNI3K
3 hematopoietic system MP:0005397 10.25 IL4 IFNB1 IL10 ACE IL17A CD40LG
4 immune system MP:0005387 10.24 IFNB1 IL10 ACE CCL2 IL17A CD40LG
5 mortality/aging MP:0010768 10.17 IL4 ACE IL10 IL17A CD40LG IL1B
6 endocrine/exocrine gland MP:0005379 10.11 CXADR IL4 ACE IL10 IL17A CD40LG
7 muscle MP:0005369 9.86 IL10 CXADR TNNI3K TLR3 IL6 TNF
8 neoplasm MP:0002006 9.7 IFNB1 ACE IL10 IL1B TLR3 IL6
9 renal/urinary system MP:0005367 9.5 ACE IL17A CD40LG IL4 TLR9 IL6
10 respiratory system MP:0005388 9.28 IL4 IL10 IL17A CXADR TLR3 IL6

Drugs & Therapeutics for Extrinsic Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Extrinsic Cardiomyopathy

Genetic Tests for Extrinsic Cardiomyopathy

Anatomical Context for Extrinsic Cardiomyopathy

Publications for Extrinsic Cardiomyopathy

Variations for Extrinsic Cardiomyopathy

Expression for Extrinsic Cardiomyopathy

Search GEO for disease gene expression data for Extrinsic Cardiomyopathy.

Pathways for Extrinsic Cardiomyopathy

Pathways related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CCL2 CD40LG CXADR IFNA6 IFNB1 IL10
2
Show member pathways
13.74 CCL2 CD40LG IFNA6 IFNB1 IL10 IL17A
3
Show member pathways
13.57 CCL2 IFNA6 IFNB1 IL10 IL17A IL1B
4
Show member pathways
13.46 CCL2 CD40LG IL10 IL17A IL1B IL4
5
Show member pathways
13.41 CCL2 CD40LG IFNA6 IFNB1 IL10 IL17A
6
Show member pathways
13.35 CCL2 CD40LG IL10 IL17A IL1B IL4
7
Show member pathways
13.03 IFNA6 IFNB1 IL4 IL6 TLR3 TNF
8
Show member pathways
13.01 ACE CCL2 IFNA6 IFNB1 IL10 IL1B
9
Show member pathways
12.87 IL1B IL4 PIK3C2A TLR3 TLR9 TNF
10
Show member pathways
12.84 IFNA6 IFNB1 IL1B IL6 TLR3 TNF
11
Show member pathways
12.84 CCL2 IFNA6 IFNB1 IL1B IL4 IL6
12
Show member pathways
12.81 CD40LG CXADR IFNA6 IL10 IL17A IL1B
13
Show member pathways
12.77 CD40LG IL1B IL6 TLR3 TLR9 TNF
14
Show member pathways
12.65 CCL2 IL10 IL17A IL1B IL6 TNF
15
Show member pathways
12.63 IFNA6 IFNB1 IL6 TLR3 TNF
16
Show member pathways
12.63 IFNA6 IFNB1 IL10 IL17A IL1B IL4
17
Show member pathways
12.57 CD40LG IL1B TLR3 TLR9 TNF
18
Show member pathways
12.52 IL10 IL17A IL1B IL4 IL6 TNF
19
Show member pathways
12.5 CD40LG IL10 IL17A IL1B IL4 IL6
20
Show member pathways
12.41 CCL2 IL1B IL4 IL6 TNF
21
Show member pathways
12.4 CCL2 IL17A IL1B IL4 IL6 TNF
22
Show member pathways
12.35 IL10 IL17A IL1B IL6 TLR3 TLR9
23
Show member pathways
12.34 IFNB1 IL6 TLR3 TLR9 TNF
24
Show member pathways
12.33 CD40LG IL10 IL1B IL4 TNF
25
Show member pathways
12.32 IL1B IL6 TLR3 TNF
26 12.32 CCL2 CD40LG IL10 IL17A IL1B IL4
27 12.31 IFNA6 IFNB1 IL10 IL1B IL6 TLR9
28
Show member pathways
12.29 IL10 IL1B IL6 TLR9 TNF
29
Show member pathways
12.29 ACE IL6 MYH6 TNF TNNI3
30
Show member pathways
12.28 IFNA6 IFNB1 IL1B TLR3 TNF
31
Show member pathways
12.26 IFNB1 IL1B IL4 IL6 TLR9 TNF
32 12.24 IL6 TLR3 TLR9 TNF
33 12.24 IL10 IL1B IL6 TNF
34
Show member pathways
12.16 CCL2 IL10 IL17A IL1B IL4 IL6
35 12.13 IFNA6 IFNB1 TLR3 TNF
36
Show member pathways
12.1 IL1B PIK3C2A TLR3 TLR9
37 12.09 CCL2 IL1B IL4 IL6 TNF
38 12.07 IL10 IL4 IL6 TNF
39 12.03 CCL2 IL1B IL6 TNF
40 11.99 CCL2 IL1B IL6 TNF
41 11.98 IL1B IL4 IL6 TNF
42 11.97 IL10 IL1B IL6 TNF
43 11.94 CCL2 IL17A IL1B IL6 TNF
44 11.92 CCL2 IL10 IL17A IL1B IL4 IL6
45 11.88 IL10 IL17A IL1B IL4 TNF
46 11.85 IL10 IL1B IL6 TNF
47
Show member pathways
11.79 CD40LG IL4 TNF
48 11.76 CCL2 IL1B IL4 IL6 TNF
49 11.75 IFNB1 IL10 IL1B IL6 TLR9 TNF
50
Show member pathways
11.73 CD40LG IL1B IL6 TNF

GO Terms for Extrinsic Cardiomyopathy

Cellular components related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ACE CCL2 CD40LG CXADR IFNA6 IFNB1
2 extracellular space GO:0005615 9.4 ACE CCL2 CD40LG IFNA6 IFNB1 IL10

Biological processes related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.98 IFNA6 IFNB1 IL6 TLR3
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B TLR3 TLR9 TNF
3 defense response GO:0006952 9.95 IFNA6 IFNB1 TLR3 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.92 CCL2 IL10 IL6 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.89 IL10 IL1B IL6 TNF
6 cellular response to organic cyclic compound GO:0071407 9.88 CCL2 IL1B TNF
7 neutrophil chemotaxis GO:0030593 9.87 CCL2 CXADR IL1B
8 response to glucocorticoid GO:0051384 9.87 IL10 IL6 TNF
9 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR3 TLR9 TNF
10 positive regulation of T cell proliferation GO:0042102 9.86 CD40LG IL1B IL4 IL6
11 B cell differentiation GO:0030183 9.85 CD40LG IFNA6 IFNB1 IL10 IL4
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 CD40LG IL1B IL6 TLR3 TLR9 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.84 IL1B TLR3 TLR9 TNF
14 protein kinase B signaling GO:0043491 9.83 CCL2 IL1B TNF
15 inflammatory response GO:0006954 9.81 CCL2 CD40LG IL10 IL17A IL1B IL6
16 B cell proliferation GO:0042100 9.8 CD40LG IFNA6 IFNB1 IL10
17 response to exogenous dsRNA GO:0043330 9.79 IFNA6 IFNB1 TLR3
18 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR3 TLR9 TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 CCL2 IL1B TNF
20 negative regulation of interleukin-6 production GO:0032715 9.76 IL10 TLR9 TNF
21 positive regulation of interleukin-12 production GO:0032735 9.75 CD40LG TLR3 TLR9
22 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR9
23 heart contraction GO:0060047 9.72 ACE TNNI3
24 cardiac muscle fiber development GO:0048739 9.72 CXADR MYH6
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
26 humoral immune response GO:0006959 9.72 CCL2 IFNA6 IFNB1 IL6 TNF
27 I-kappaB phosphorylation GO:0007252 9.71 TLR3 TLR9
28 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.71 TLR3 TLR9
29 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
30 neutrophil mediated immunity GO:0002446 9.71 ACE IL6
31 positive regulation of chemokine production GO:0032722 9.71 IL6 TLR3 TLR9 TNF
32 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
33 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IL10 IL4
35 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TLR3 TNF
37 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR3 TLR9
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
39 necroptotic signaling pathway GO:0097527 9.67 TLR3 TNF
40 type 2 immune response GO:0042092 9.67 IL10 IL4
41 negative regulation of interleukin-8 production GO:0032717 9.67 IL10 TLR9
42 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
43 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
44 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TLR3 TLR9 TNF
45 positive regulation of toll-like receptor signaling pathway GO:0034123 9.64 TLR3 TLR9
46 regulation of isotype switching GO:0045191 9.64 IL10 IL4
47 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
48 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.63 TLR3 TLR9
49 receptor biosynthetic process GO:0032800 9.61 IL10 TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF

Molecular functions related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CCL2 CD40LG IFNA6 IFNB1 IL10 IL17A
2 cytokine receptor binding GO:0005126 9.13 IFNA6 IFNB1 IL4

Sources for Extrinsic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....