MCID: EXT035
MIFTS: 33

Extrinsic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Extrinsic Cardiomyopathy

MalaCards integrated aliases for Extrinsic Cardiomyopathy:

Name: Extrinsic Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3978
ICD9CM 36 425.8
UMLS 74 C0155699

Summaries for Extrinsic Cardiomyopathy

Disease Ontology : 12 A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.

MalaCards based summary : Extrinsic Cardiomyopathy is related to myocarditis and angioimmunoblastic lymphadenopathy with dysproteinemia. An important gene associated with Extrinsic Cardiomyopathy is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Related phenotypes are immune system and homeostasis/metabolism

Related Diseases for Extrinsic Cardiomyopathy

Diseases related to Extrinsic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.0 CXADR IL6 MYH6 NOS2 TNF TNNI3
2 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
3 exudative glomerulonephritis 10.6 IL1B TNF
4 recurrent corneal erosion 10.6 IL1B IL6
5 bagassosis 10.6 IL1B IL6
6 staphylococcal toxic shock syndrome 10.6 IL1B TNF
7 autoimmune myocarditis 10.6 IL6 TNF
8 leukomalacia 10.6 IL6 TNF
9 scorpion envenomation 10.6 IL6 TNF
10 multifocal choroiditis 10.5 IL10 TNF
11 punctate inner choroidopathy 10.5 IL10 TNF
12 skin sarcoidosis 10.5 ACE TNF
13 uveoparotid fever 10.5 ACE TNF
14 eye lymphoma 10.5 IL10 IL6
15 tick paralysis 10.5 PIK3C2A TNNI3
16 autoimmune atherosclerosis 10.5 ACE IL10
17 subacute cutaneous lupus erythematosus 10.5 ACE TNF
18 trench fever 10.5 TLR4 TNF
19 diabetic foot ulcers 10.5 CCL2 IL6
20 vibrio vulnificus infection 10.5 IL6 PIK3C2A
21 acute anterolateral myocardial infarction 10.5 ACE PIK3C2A
22 prosthetic joint infection 10.5 IL1B TLR4
23 purulent labyrinthitis 10.5 CCL2 IL1B
24 systemic onset juvenile idiopathic arthritis 10.5 PRF1 TNF
25 hyperlucent lung 10.5 IL10 IL4
26 cerebral palsy 10.5 IL1B IL6 TNF
27 endometritis 10.5 IL1B IL6 TNF
28 pulpitis 10.4 IL1B IL6 TNF
29 hematopoietic stem cell transplantation 10.4 IL10 IL6 TNF
30 post-transplant lymphoproliferative disease 10.4 IL10 IL6 TNF
31 aseptic meningitis 10.4 IL10 IL1B TNF
32 monocytic leukemia 10.4 IL1B IL6 TNF
33 sarcoidosis 1 10.4 ACE IL1B TNF
34 acute respiratory distress syndrome 10.4 IL1B IL6 TNF
35 plasmodium vivax malaria 10.4 IL10 IL6 TNF
36 intermediate uveitis 10.4 IL10 IL6 TNF
37 rheumatic fever 10.4 IL10 IL6 TNF
38 peptic ulcer disease 10.4 IL10 IL1B TNF
39 mixed connective tissue disease 10.4 IL10 IL6 TNF
40 virus associated hemophagocytic syndrome 10.4 IL4 PIK3C2A
41 human immunodeficiency virus infectious disease 10.4 IL10 IL6 TNF
42 atrial standstill 1 10.4 ACE MYH6 TNNI3
43 variola major 10.4 TLR3 TLR4
44 intrinsic cardiomyopathy 10.4 ACE MYH6 TNNI3
45 panuveitis 10.4 IL10 IL17A TNF
46 drug reaction with eosinophilia and systemic symptoms 10.4 CRP TNF
47 crimean-congo hemorrhagic fever 10.4 IL6 PIK3C2A TNF
48 cold agglutinin disease 10.4 CRP IL6
49 cysticercosis 10.4 IL1B IL6 TLR4
50 tropical spastic paraparesis 10.4 IL10 IL17A IL6

Graphical network of the top 20 diseases related to Extrinsic Cardiomyopathy:



Diseases related to Extrinsic Cardiomyopathy

Symptoms & Phenotypes for Extrinsic Cardiomyopathy

MGI Mouse Phenotypes related to Extrinsic Cardiomyopathy:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.42 ACE CCL2 CRP CXADR IFNB1 IL10
2 homeostasis/metabolism MP:0005376 10.41 ACE CRP CXADR IFNB1 IL10 IL17A
3 cardiovascular system MP:0005385 10.4 ACE CRP CXADR IL10 IL1B IL6
4 hematopoietic system MP:0005397 10.37 ACE CXADR IFNB1 IL10 IL17A IL1B
5 behavior/neurological MP:0005386 10.31 ACE CXADR IL10 IL6 MYH6 NOS2
6 mortality/aging MP:0010768 10.31 ACE CXADR IL10 IL17A IL1B IL4
7 endocrine/exocrine gland MP:0005379 10.24 ACE CXADR IL10 IL17A IL4 IL6
8 digestive/alimentary MP:0005381 10.15 CXADR IL10 IL17A IL4 IL6 NOS2
9 liver/biliary system MP:0005370 10.11 ACE IL10 IL4 IL6 MYH6 NOS2
10 integument MP:0010771 10.08 IL10 IL1B IL4 IL6 NOS2 PRF1
11 neoplasm MP:0002006 10.07 ACE IFNB1 IL10 IL1B IL6 NOS2
12 muscle MP:0005369 10.06 CXADR IL10 IL6 MYH6 NOS2 TLR3
13 nervous system MP:0003631 10.02 IFNB1 IL10 IL1B IL4 IL6 NOS2
14 reproductive system MP:0005389 9.81 ACE IL10 IL4 IL6 NOS2 PRF1
15 renal/urinary system MP:0005367 9.8 ACE IL17A IL4 IL6 NOS2 PIK3C2A
16 respiratory system MP:0005388 9.7 CXADR IL10 IL17A IL4 IL6 MYH6
17 skeleton MP:0005390 9.28 IFNB1 IL10 IL17A IL1B IL4 IL6

Drugs & Therapeutics for Extrinsic Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Extrinsic Cardiomyopathy

Genetic Tests for Extrinsic Cardiomyopathy

Anatomical Context for Extrinsic Cardiomyopathy

Publications for Extrinsic Cardiomyopathy

Variations for Extrinsic Cardiomyopathy

Expression for Extrinsic Cardiomyopathy

Search GEO for disease gene expression data for Extrinsic Cardiomyopathy.

Pathways for Extrinsic Cardiomyopathy

Pathways related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CCL2 CRP CXADR ICOSLG IFNB1 IL10
2
Show member pathways
13.76 CCL2 IFNB1 IL10 IL17A IL1B IL4
3
Show member pathways
13.58 CCL2 IFNB1 IL10 IL17A IL1B IL4
4
Show member pathways
13.5 CCL2 IL10 IL17A IL1B IL4 IL6
5
Show member pathways
13.45 CCL2 IFNB1 IL10 IL17A IL1B IL4
6
Show member pathways
13.38 CCL2 IL10 IL17A IL1B IL4 IL6
7
Show member pathways
13.22 ACE CCL2 IFNB1 IL10 IL1B IL6
8
Show member pathways
13.05 IFNB1 IL4 IL6 TLR3 TLR4 TNF
9
Show member pathways
13.05 CCL2 IFNB1 IL1B IL6 TLR3 TLR4
10
Show member pathways
12.87 CXADR ICOSLG IL10 IL17A IL1B IL4
11
Show member pathways
12.85 IFNB1 IL1B IL6 TLR3 TLR4 TNF
12
Show member pathways
12.75 IL1B IL6 TLR3 TLR4 TNF
13
Show member pathways
12.71 IL10 IL17A IL1B IL4 IL6 TLR4
14
Show member pathways
12.7 CCL2 IL10 IL17A IL1B IL6 NOS2
15 12.67 CCL2 IL10 IL17A IL1B IL4 TLR3
16
Show member pathways
12.67 CCL2 IFNB1 IL1B IL4 IL6 TLR3
17
Show member pathways
12.55 IL10 IL17A IL1B IL4 IL6 TNF
18
Show member pathways
12.46 CCL2 CRP IL1B IL4 IL6 TNF
19
Show member pathways
12.45 CCL2 IL17A IL1B IL4 IL6 TNF
20
Show member pathways
12.43 IL1B IL6 NOS2 TLR3 TLR4 TNF
21
Show member pathways
12.39 IL10 IL1B IL4 NOS2 TLR4 TNF
22
Show member pathways
12.38 IFNB1 IL10 IL17A IL1B IL4 IL6
23
Show member pathways
12.37 IFNB1 IL6 TLR3 TLR4 TNF
24
Show member pathways
12.33 ACE IL6 MYH6 TNF TNNI3
25
Show member pathways
12.32 HIST2H2AA3 IFNB1 IL1B TLR3 TLR4 TNF
26 12.32 IFNB1 IL10 IL1B IL6 NOS2 TLR4
27 12.29 IL6 NOS2 TLR3 TLR4 TNF
28
Show member pathways
12.28 IL1B IL6 NOS2 TNF
29
Show member pathways
12.27 IL10 IL1B IL6 TNF
30 12.24 IL10 IL1B IL6 TNF
31
Show member pathways
12.24 IFNB1 IL1B IL4 IL6 NOS2 TLR4
32
Show member pathways
12.18 CCL2 IL10 IL17A IL1B IL4 IL6
33
Show member pathways
12.16 IL1B IL4 IL6 TLR4 TNF
34
Show member pathways
12.12 IL1B PIK3C2A TLR3 TLR4
35 12.09 CCL2 IFNB1 IL1B IL6 TNF
36 12.08 IL10 IL4 IL6 TNF
37
Show member pathways
12.06 IL10 IL17A IL1B IL6 TLR3 TLR4
38 12.03 IL10 IL1B IL6 NOS2 TLR4 TNF
39 12.01 CCL2 IL1B IL6 TNF
40 11.99 IL1B IL4 IL6 TNF
41 11.99 CCL2 IL1B IL4 IL6 NOS2 TLR4
42 11.97 CCL2 IL17A IL1B IL6 TLR4 TNF
43 11.94 IL1B IL6 NOS2 TLR4
44 11.92 IL10 IL17A IL1B IL4 TNF
45 11.87 IFNB1 IL10 IL1B IL6 TNF
46 11.81 IL10 IL1B IL6 NOS2 TLR4 TNF
47
Show member pathways
11.78 IL1B IL6 NOS2 TNF
48 11.78 CCL2 IL1B IL4 IL6 TNF
49 11.71 IL1B IL6 TLR4 TNF
50 11.66 CCL2 IL1B NOS2 TLR4 TNF

GO Terms for Extrinsic Cardiomyopathy

Cellular components related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ACE CCL2 CRP CXADR IFNB1 IL10
2 external side of plasma membrane GO:0009897 9.55 ACE ICOSLG IL17A TLR4 TNF
3 extracellular space GO:0005615 9.36 ACE CCL2 CRP IFNB1 IL10 IL17A

Biological processes related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B TLR3 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.99 IL10 IL1B NOS2 TLR4
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 IL1B IL6 TLR3 TLR4 TNF
4 defense response GO:0006952 9.96 ICOSLG IFNB1 TLR3 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.94 IL10 IL1B IL6 TNF
6 cellular response to interferon-gamma GO:0071346 9.92 CCL2 NOS2 TLR3 TLR4
7 defense response to Gram-negative bacterium GO:0050829 9.91 IL6 NOS2 TLR4
8 neutrophil chemotaxis GO:0030593 9.91 CCL2 CXADR IL1B
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 TLR4 TNF
10 cellular response to mechanical stimulus GO:0071260 9.91 IL1B TLR3 TLR4
11 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR3 TLR4 TNF
12 positive regulation of inflammatory response GO:0050729 9.9 TLR3 TLR4 TNF
13 B cell differentiation GO:0030183 9.9 IFNB1 IL10 IL4
14 cellular response to organic cyclic compound GO:0071407 9.9 CCL2 IL1B TNF
15 regulation of insulin secretion GO:0050796 9.9 IL1B NOS2 TNF
16 cellular response to drug GO:0035690 9.9 IL1B NOS2 TLR3
17 apoptotic signaling pathway GO:0097190 9.89 TLR3 TLR4 TNF
18 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.88 TLR3 TLR4 TNF
19 positive regulation of T cell proliferation GO:0042102 9.88 IL1B IL4 IL6
20 humoral immune response GO:0006959 9.88 CCL2 IFNB1 IL6 TNF
21 positive regulation of interferon-gamma production GO:0032729 9.86 IL1B TLR4 TNF
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 IL1B TLR3 TLR4 TNF
23 regulation of signaling receptor activity GO:0010469 9.86 CCL2 IFNB1 IL10 IL17A IL1B IL4
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IL1B TLR4 TNF
25 protein kinase B signaling GO:0043491 9.83 CCL2 IL1B TNF
26 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TNF
27 negative regulation of neurogenesis GO:0050768 9.8 IL1B IL6 TNF
28 negative regulation of osteoclast differentiation GO:0045671 9.79 IL4 TLR3 TLR4
29 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 CCL2 IL1B TLR4 TNF
30 positive regulation of glial cell proliferation GO:0060252 9.77 IL1B IL6 TNF
31 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
33 I-kappaB phosphorylation GO:0007252 9.74 TLR3 TLR4
34 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.73 TLR3 TLR4
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
36 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR3 TLR4 TNF
37 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
38 hyperosmotic response GO:0006972 9.72 ICOSLG TLR3
39 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B IL6 TLR3 TLR4 TNF
40 neutrophil mediated immunity GO:0002446 9.71 ACE IL6
41 positive regulation of interferon-beta biosynthetic process GO:0045359 9.71 TLR3 TLR4
42 negative regulation of lipid storage GO:0010888 9.71 CRP IL6 TNF
43 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.7 TLR3 TLR4
44 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
45 necroptotic signaling pathway GO:0097527 9.7 TLR3 TNF
46 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TLR3 TNF
47 cellular response to lipopolysaccharide GO:0071222 9.7 CCL2 IL10 IL1B IL6 NOS2 TLR4
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IL10 IL4 TLR4
50 positive regulation of fever generation GO:0031622 9.68 IL1B TNF

Molecular functions related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 IFNB1 IL10 IL17A IL1B IL4

Sources for Extrinsic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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