MCID: EXT035
MIFTS: 29

Extrinsic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Extrinsic Cardiomyopathy

MalaCards integrated aliases for Extrinsic Cardiomyopathy:

Name: Extrinsic Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3978
ICD9CM 34 425.8
SNOMED-CT 67 195580005
UMLS 70 C0155699

Summaries for Extrinsic Cardiomyopathy

Disease Ontology : 12 A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.

MalaCards based summary : Extrinsic Cardiomyopathy is related to myocarditis and external pathological resorption. An important gene associated with Extrinsic Cardiomyopathy is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include bone, heart and lung.

Related Diseases for Extrinsic Cardiomyopathy

Diseases related to Extrinsic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 773)
# Related Disease Score Top Affiliating Genes
1 myocarditis 32.0 TNNI3 TNF MIR590 IL6 IL1B IL10
2 external pathological resorption 10.6 TNF IL6
3 dermatomyositis 10.6 MIR223 MIR210 MIR21
4 scorpion envenomation 10.5 TNF IL6
5 punctate inner choroidopathy 10.5 TNF IL10
6 conjunctivitis 10.5 TNF IL6 IL10
7 cork-handlers' disease 10.5 CD8A CD4
8 necrotic uveal melanoma 10.5 CD8A CD4
9 tropical endomyocardial fibrosis 10.5 TNF IL10
10 physiological polycythemia 10.5 TNF IL6 IL1B
11 blastomycosis 10.5 IL6 CD4 CCR6
12 immune-complex glomerulonephritis 10.5 ICOSLG H2AC18 CD4
13 idiopathic anterior uveitis 10.5 TNF IL6
14 enterocolitis 10.5 TNF IL6 IL10
15 hyper ige recurrent infection syndrome 1 10.5 IL6 CD4 CCR6
16 lung abscess 10.5 TNF IL6 CD4
17 goodpasture syndrome 10.5 H2AC18 CD4 CCR6
18 arachnoiditis 10.5 TNF IL1B CD4
19 ulcer of lower limbs 10.5 TNF IL6 IL1B
20 esophageal candidiasis 10.5 CD8A CD4 CCR6
21 parasitic ectoparasitic infectious disease 10.5 H2AC18 CD4 CCR6
22 transient arthritis 10.5 IL6 IL1B CD4
23 early yaws 10.5 CD8A CD4
24 type 1 diabetes mellitus 23 10.5 TNF CD8A CD4
25 progressive relapsing multiple sclerosis 10.5 SERPINA3 H2AC18 CCR6
26 mikulicz disease 10.5 IL10 CD4 CCR6
27 salpingitis 10.5 TNF IL6 CD4
28 stachybotrys chartarum 10.5 TNF IL6 IL1B
29 keratoconjunctivitis sicca 10.5 TNF CD4 CCR6
30 staphylococcal toxic shock syndrome 10.5 TNF IL1B
31 carbuncle 10.5 TNF IL6 IL1B
32 bullous skin disease 10.5 ICOSLG CD4 CCR6
33 immunodeficiency 35 10.5 IL10 ICOSLG CCR6
34 miyoshi muscular dystrophy 1 10.5 MIR223 MIR210 MIR21
35 paratyphoid fever 10.5 TNF IL1B CCR6
36 streptococcal toxic-shock syndrome 10.5 TNF IL6
37 subcutaneous mycosis 10.5 IL10 CD4 CCR6
38 anthracosis 10.5 TNF IL6 IL1B
39 oral tuberculosis 10.5 TNF CD8A CD4
40 autoimmune cholangitis 10.5 CD8A CD4 CCR6
41 immunodeficiency with hyper-igm, type 3 10.5 ICOSLG CD8A CD4
42 eyelid disease 10.5 TNF CD4 CCR6
43 viral exanthem 10.5 TNF CD8A CD4
44 adult syndrome 10.5 IL6 ICOSLG H2AC18
45 peptic esophagitis 10.5 TNF IL6 IL1B
46 acute proliferative glomerulonephritis 10.5 TNF ICOSLG CD4 CCR6
47 blood protein disease 10.5 IL6 ICOSLG H2AC18 CCR6
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
49 bursitis 10.5 TNF IL6 IL1B
50 gingival recession 10.5 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Extrinsic Cardiomyopathy:



Diseases related to Extrinsic Cardiomyopathy

Symptoms & Phenotypes for Extrinsic Cardiomyopathy

Drugs & Therapeutics for Extrinsic Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Extrinsic Cardiomyopathy

Genetic Tests for Extrinsic Cardiomyopathy

Anatomical Context for Extrinsic Cardiomyopathy

MalaCards organs/tissues related to Extrinsic Cardiomyopathy:

40
Bone, Heart, Lung, Skin, Kidney, Liver, Eye

Publications for Extrinsic Cardiomyopathy

Variations for Extrinsic Cardiomyopathy

Expression for Extrinsic Cardiomyopathy

Search GEO for disease gene expression data for Extrinsic Cardiomyopathy.

Pathways for Extrinsic Cardiomyopathy

Pathways related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 TNF IL6 IL1B IL10 ICOSLG CD8A
2
Show member pathways
12.58 TNF IL6 IL1B IL10 CD8A CD4
3
Show member pathways
12.55 TNF IL6 IL1B IL10 CD4
4
Show member pathways
12.54 TNF IL6 IL1B IL10 CD4
5 12.44 MIR423 MIR223 MIR210 MIR21 MIR199A1 MIR16-1
6
Show member pathways
12.3 TNF SERPINA3 IL6 IL1B
7
Show member pathways
12.29 TNF IL6 IL10 CCR6
8
Show member pathways
12.21 TNNI3 TNF IL6 ACE
9 12.19 TNF IL6 IL1B IL10
10
Show member pathways
12.17 TNF IL6 IL1B IL10
11 12.08 TNF MIR21 MIR10A IL1B
12 12.05 TNF MIR210 MIR16-1 IL6 IL1B IL10
13 11.97 TNF IL6 IL10 CD8A CD4
14 11.94 TNF IL6 IL1B IL10
15 11.89 TNF IL6 IL1B IL10
16 11.87 TNF IL6 IL1B IL10 CD8A CD4
17 11.85 TNF IL6 IL1B CD8A CD4
18 11.75 TNF IL6 IL1B IL10
19
Show member pathways
11.71 TNF IL6 IL1B IL10 CD4
20
Show member pathways
11.63 TNF IL6 IL1B
21 11.63 TNF IL6 IL1B
22 11.58 TNF IL6 IL1B
23 11.54 TNF IL6 IL1B IL10
24 11.54 TNF IL6 IL10 ICOSLG CCR6
25 11.54 IL10 CD8A CD4 CCR6 IL1B TNF
26 11.52 TNF IL6 IL1B IL10
27 11.49 MIR16-1 IL6 IL1B
28 11.45 TNF IL6 IL1B
29 11.36 TNF IL6 IL1B IL10
30 11.32 TNF IL6 IL1B IL10
31 11.28 TNF IL6 IL1B
32 11.26 TNF IL6 IL1B
33 10.97 TNF IL6 IL1B IL10 CD8A CD4
34 10.82 TNF IL6 IL1B IL10 CD4

GO Terms for Extrinsic Cardiomyopathy

Cellular components related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.47 TNF SERPINA3 MIR590 MIR423 MIR223 MIR210
2 external side of plasma membrane GO:0009897 9.43 TNF ICOSLG CD8A CD4 CCR6 ACE

Biological processes related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.08 MIR21 MIR16-1 IL6 IL1B IL10
2 positive regulation of protein phosphorylation GO:0001934 9.97 TNF MIR21 IL1B CD4
3 cytokine-mediated signaling pathway GO:0019221 9.96 TNF IL6 IL1B IL10 CD4
4 positive regulation of angiogenesis GO:0045766 9.92 MIR210 MIR21 MIR199A1 IL1B
5 negative regulation of inflammatory response GO:0050728 9.88 MIR590 MIR223 MIR16-1 IL10
6 regulation of insulin secretion GO:0050796 9.86 TNF IL6 IL1B
7 positive regulation of osteoblast differentiation GO:0045669 9.86 MIR210 MIR21 IL6
8 response to glucocorticoid GO:0051384 9.85 TNF IL6 IL10
9 positive regulation of T cell proliferation GO:0042102 9.85 IL6 IL1B CD4
10 positive regulation of interleukin-8 production GO:0032757 9.83 TNF IL6 IL1B
11 humoral immune response GO:0006959 9.83 TNF IL6 CCR6
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNF IL6 IL1B IL10
13 positive regulation of cytokine production GO:0001819 9.82 TNF MIR21 IL10
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.81 TNF MIR21 IL10
15 miRNA mediated inhibition of translation GO:0035278 9.81 MIR590 MIR210 MIR21 MIR16-1
16 T cell activation GO:0042110 9.8 ICOSLG CD8A CD4
17 positive regulation of epithelial to mesenchymal transition GO:0010718 9.8 MIR21 IL6 IL1B
18 negative regulation of endothelial cell proliferation GO:0001937 9.77 TNF MIR21 MIR16-1
19 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.77 MIR590 MIR223 MIR21
20 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.76 MIR590 MIR21 MIR199A1
21 negative regulation of mitotic cell cycle GO:0045930 9.74 TNF MIR16-1 IL10
22 cellular response to lipopolysaccharide GO:0071222 9.72 TNF MIR21 IL6 IL1B IL10
23 positive regulation of JAK-STAT cascade GO:0046427 9.71 TNF IL6 IL10
24 immune response GO:0006955 9.7 TNF IL6 IL1B IL10 CD8A CD4
25 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
26 neutrophil mediated immunity GO:0002446 9.69 IL6 ACE
27 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
28 endothelial cell apoptotic process GO:0072577 9.67 TNF IL10
29 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.66 MIR21 IL6
30 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.66 MIR210 MIR21
31 negative regulation of neurogenesis GO:0050768 9.65 TNF IL6 IL1B
32 negative regulation of cytokine production involved in immune response GO:0002719 9.64 TNF IL10
33 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
34 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.63 TNF MIR21 IL6
35 positive regulation of cardiac muscle tissue regeneration GO:1905180 9.61 MIR590 MIR199A1
36 sequestering of triglyceride GO:0030730 9.61 TNF IL1B
37 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 TNF IL1B IL10
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 TNF IL1B
40 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 TNF MIR21 IL6
41 negative regulation of gap junction assembly GO:1903597 9.49 IL1B ACE
42 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
43 gene silencing by miRNA GO:0035195 9.23 MIR590 MIR423 MIR223 MIR210 MIR21 MIR199A1
44 vascular endothelial growth factor production GO:0010573 9.13 TNF IL6 IL1B

Molecular functions related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL1B IL10
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.23 MIR590 MIR423 MIR223 MIR210 MIR21 MIR199A1

Sources for Extrinsic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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