MCID: EXT035
MIFTS: 37

Extrinsic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Extrinsic Cardiomyopathy

MalaCards integrated aliases for Extrinsic Cardiomyopathy:

Name: Extrinsic Cardiomyopathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3978
ICD9CM 35 425.8
UMLS 73 C0155699

Summaries for Extrinsic Cardiomyopathy

Disease Ontology : 12 A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.

MalaCards based summary : Extrinsic Cardiomyopathy is related to myocarditis and angioimmunoblastic lymphadenopathy with dysproteinemia. An important gene associated with Extrinsic Cardiomyopathy is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, skin and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Extrinsic Cardiomyopathy

Diseases related to Extrinsic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.3 CXADR ICAM1 IL6 MYH6 TNF TNNI3
2 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
3 exudative glomerulonephritis 10.4 IL1B TNF
4 recurrent corneal erosion 10.4 IL1B IL6
5 bagassosis 10.4 IL1B IL6
6 staphylococcal toxic shock syndrome 10.4 IL1B TNF
7 leukomalacia 10.4 IL6 TNF
8 scorpion envenomation 10.3 IL6 TNF
9 paraneoplastic syndromes 10.3 IL1B IL6
10 skin sarcoidosis 10.3 ACE TNF
11 uveoparotid fever 10.3 ACE TNF
12 microscopic polyangiitis 10.3 IL10 TNF
13 multifocal choroiditis 10.3 IL10 TNF
14 punctate inner choroidopathy 10.3 IL10 TNF
15 tick paralysis 10.3 PIK3C2A TNNI3
16 subacute cutaneous lupus erythematosus 10.3 ACE TNF
17 autoimmune atherosclerosis 10.3 ACE IL10
18 purulent labyrinthitis 10.3 CCL2 IL1B
19 vibrio vulnificus infection 10.3 IL6 PIK3C2A
20 acute anterolateral myocardial infarction 10.3 ACE PIK3C2A
21 autoimmune myocarditis 10.3 IL4 TNF
22 trench fever 10.3 TLR4 TNF
23 hyperlucent lung 10.3 IL10 IL4
24 prosthetic joint infection 10.3 IL1B TLR4
25 dry eye syndrome 10.3 IL6 TLR9 TNF
26 reproductive system disease 10.3 IL6 TLR9 TNF
27 female reproductive system disease 10.3 IL6 TLR9 TNF
28 gastrointestinal system cancer 10.3 IL6 TLR9 TNF
29 cerebral palsy 10.3 IL1B IL6 TNF
30 endometritis 10.3 IL1B IL6 TNF
31 pulpitis 10.3 IL1B IL6 TNF
32 placenta disease 10.3 IL1B IL6 TLR9
33 poems syndrome 10.3 IL1B IL6 TNF
34 glossitis 10.3 IL1B IL6 TNF
35 laryngitis 10.3 IL1B IL6 TNF
36 periapical periodontitis 10.3 IL1B IL6 TNF
37 monocytic leukemia 10.3 IL1B IL6 TNF
38 acute vascular insufficiency of intestine 10.3 IL1B IL6 TNF
39 mucocutaneous leishmaniasis 10.3 IL10 TLR9 TNF
40 osteosclerotic myeloma 10.3 IL1B IL6 TNF
41 acute respiratory distress syndrome 10.3 IL1B IL6 TNF
42 hypersensitivity reaction type iv disease 10.3 ACE TLR9 TNF
43 irritable bowel syndrome 10.3 IL10 TLR9 TNF
44 aseptic meningitis 10.3 IL10 IL1B TNF
45 virus associated hemophagocytic syndrome 10.3 IL4 PIK3C2A
46 hematopoietic stem cell transplantation 10.3 IL10 IL6 TNF
47 dengue hemorrhagic fever 10.3 IL10 IL6 TNF
48 post-transplant lymphoproliferative disease 10.3 IL10 IL6 TNF
49 drug reaction with eosinophilia and systemic symptoms 10.3 CRP TNF
50 peptic ulcer disease 10.3 IL10 IL1B TNF

Graphical network of the top 20 diseases related to Extrinsic Cardiomyopathy:



Diseases related to Extrinsic Cardiomyopathy

Symptoms & Phenotypes for Extrinsic Cardiomyopathy

MGI Mouse Phenotypes related to Extrinsic Cardiomyopathy:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ACE CRP CXADR ICAM1 IFNB1 IL10
2 cardiovascular system MP:0005385 10.31 ACE CRP CXADR ICAM1 IL10 IL1B
3 immune system MP:0005387 10.31 ACE CCL2 CRP CXADR ICAM1 IFNB1
4 hematopoietic system MP:0005397 10.27 ACE CXADR ICAM1 IFNB1 IL10 IL17A
5 mortality/aging MP:0010768 10.17 ACE CXADR ICAM1 IL10 IL17A IL1B
6 digestive/alimentary MP:0005381 10.13 CXADR ICAM1 IL10 IL17A IL4 IL6
7 liver/biliary system MP:0005370 9.91 ACE IL10 IL4 IL6 MYH6 TLR4
8 muscle MP:0005369 9.91 CXADR ICAM1 IL10 IL6 MYH6 TLR4
9 neoplasm MP:0002006 9.76 ACE ICAM1 IFNB1 IL10 IL1B IL6
10 renal/urinary system MP:0005367 9.5 ACE IL17A IL4 IL6 PIK3C2A TLR4
11 respiratory system MP:0005388 9.28 CXADR IL10 IL17A IL4 IL6 MYH6

Drugs & Therapeutics for Extrinsic Cardiomyopathy

Search Clinical Trials , NIH Clinical Center for Extrinsic Cardiomyopathy

Genetic Tests for Extrinsic Cardiomyopathy

Anatomical Context for Extrinsic Cardiomyopathy

MalaCards organs/tissues related to Extrinsic Cardiomyopathy:

41
Lung, Skin, Bone, Heart, Lymph Node, Eye, Spinal Cord

Publications for Extrinsic Cardiomyopathy

Variations for Extrinsic Cardiomyopathy

Expression for Extrinsic Cardiomyopathy

Search GEO for disease gene expression data for Extrinsic Cardiomyopathy.

Pathways for Extrinsic Cardiomyopathy

Pathways related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CCL2 CRP CXADR ICAM1 IFNA6 IFNB1
2
Show member pathways
13.76 CCL2 IFNA6 IFNB1 IL10 IL17A IL1B
3
Show member pathways
13.63 CCL2 ICAM1 IFNA6 IFNB1 IL10 IL17A
4
Show member pathways
13.5 CCL2 IL10 IL17A IL1B IL4 IL6
5
Show member pathways
13.46 CCL2 ICAM1 IFNA6 IFNB1 IL10 IL17A
6
Show member pathways
13.39 CCL2 IL10 IL17A IL1B IL4 IL6
7
Show member pathways
13.16 CCL2 ICAM1 IFNA6 IFNB1 IL1B IL6
8
Show member pathways
13.1 ACE CCL2 IFNA6 IFNB1 IL10 IL1B
9
Show member pathways
13.06 IFNA6 IFNB1 IL4 IL6 TLR4 TNF
10
Show member pathways
12.95 CXADR ICAM1 IFNA6 IL10 IL17A IL1B
11
Show member pathways
12.86 IFNA6 IFNB1 IL1B IL6 TLR4 TNF
12
Show member pathways
12.84 CCL2 ICAM1 IFNA6 IFNB1 IL1B IL4
13
Show member pathways
12.77 IL1B IL6 TLR4 TLR9 TNF
14
Show member pathways
12.71 IL10 IL17A IL1B IL4 IL6 TLR4
15
Show member pathways
12.69 CCL2 IL10 IL17A IL1B IL6 TNF
16 12.68 CCL2 IL10 IL17A IL1B IL4 TLR9
17
Show member pathways
12.61 ICAM1 IFNA6 IFNB1 IL4 TNF
18
Show member pathways
12.54 IL10 IL17A IL1B IL4 IL6 TNF
19
Show member pathways
12.49 IFNA6 IFNB1 IL10 IL4 IL6
20
Show member pathways
12.47 CCL2 CRP ICAM1 IL1B IL4 IL6
21
Show member pathways
12.46 CCL2 IL17A IL1B IL4 IL6 TNF
22 12.41 ICAM1 IFNA6 IFNB1 IL6 TNF
23
Show member pathways
12.4 IFNA6 IFNB1 IL10 IL17A IL1B IL4
24
Show member pathways
12.38 IFNB1 IL6 TLR4 TLR9 TNF
25
Show member pathways
12.37 IL10 IL1B IL4 TLR4 TNF
26
Show member pathways
12.35 IL1B IL6 TLR4 TNF
27
Show member pathways
12.33 IL10 IL1B IL6 TLR9 TNF
28
Show member pathways
12.33 ACE IL6 MYH6 TNF TNNI3
29
Show member pathways
12.32 IFNA6 IFNB1 IL1B TLR4 TNF
30
Show member pathways
12.31 CCL2 ICAM1 IL1B MYH6 TLR4 TLR9
31
Show member pathways
12.3 IFNB1 IL1B IL4 IL6 TLR4 TLR9
32 12.29 IFNA6 IFNB1 IL10 IL1B IL6 TLR4
33 12.26 IL6 TLR4 TLR9 TNF
34 12.25 IL10 IL1B IL6 TNF
35
Show member pathways
12.19 CCL2 ICAM1 IL10 IL17A IL1B IL4
36 12.18 CCL2 ICAM1 IL1B TNF
37
Show member pathways
12.16 IL1B IL4 IL6 TLR4 TNF
38
Show member pathways
12.15 IL10 IL17A IL1B IL6 TLR4 TLR9
39
Show member pathways
12.12 IL1B PIK3C2A TLR4 TLR9
40 12.12 CCL2 ICAM1 IFNB1 IL1B IL6 TNF
41 12.1 CCL2 ICAM1 IL1B IL4 IL6 TLR4
42 12.09 IL10 IL4 IL6 TNF
43 12.05 CCL2 ICAM1 IL1B IL6 TNF
44 12.02 IL10 IL1B IL6 TLR4 TNF
45 12 IL1B IL4 IL6 TNF
46 11.99 ICAM1 IL1B TLR4 TNF
47
Show member pathways
11.98 ICAM1 IL17A IL6 TLR4
48 11.93 IL10 IL17A IL1B IL4 TNF
49 11.9 IL10 IL1B IL6 TLR4 TNF
50 11.9 CCL2 ICAM1 IL17A IL1B IL6 TLR4

GO Terms for Extrinsic Cardiomyopathy

Cellular components related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ACE CCL2 CRP CXADR IFNA6 IFNB1
2 external side of plasma membrane GO:0009897 9.55 ACE ICAM1 IL17A TLR4 TNF
3 extracellular space GO:0005615 9.4 ACE CCL2 CRP ICAM1 IFNA6 IFNB1

Biological processes related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B TLR4 TLR9 TNF
2 response to lipopolysaccharide GO:0032496 9.99 ICAM1 IL10 IL1B TLR4
3 immune response GO:0006955 9.97 CCL2 IL10 IL17A IL1B IL4 IL6
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.94 IL10 IL1B IL6 TNF
5 positive regulation of JNK cascade GO:0046330 9.93 IL1B TLR4 TLR9 TNF
6 B cell differentiation GO:0030183 9.92 IFNA6 IFNB1 IL10 IL4
7 defense response to Gram-negative bacterium GO:0050829 9.91 IL6 TLR4 TLR9
8 response to glucocorticoid GO:0051384 9.91 IL10 IL1B IL6 TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 ICAM1 IL1B IL6 TLR4 TLR9 TNF
10 neutrophil chemotaxis GO:0030593 9.9 CCL2 CXADR IL1B
11 cellular response to interleukin-1 GO:0071347 9.9 CCL2 ICAM1 IL17A
12 positive regulation of inflammatory response GO:0050729 9.9 TLR4 TLR9 TNF
13 cellular response to organic cyclic compound GO:0071407 9.9 CCL2 IL1B TNF
14 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.89 TLR4 TLR9 TNF
15 positive regulation of T cell proliferation GO:0042102 9.89 IL1B IL4 IL6
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 IL1B TLR4 TLR9 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.86 IL1B TLR4 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 ICAM1 IL1B TLR4 TNF
19 positive regulation of JUN kinase activity GO:0043507 9.85 IL1B TLR9 TNF
20 positive regulation of B cell proliferation GO:0030890 9.84 IL4 TLR4 TLR9
21 protein kinase B signaling GO:0043491 9.84 CCL2 IL1B TNF
22 negative regulation of endothelial cell apoptotic process GO:2000352 9.83 ICAM1 IL10 IL4
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 CCL2 IL1B TLR4 TNF
24 B cell proliferation GO:0042100 9.82 IFNA6 IFNB1 IL10
25 negative regulation of neurogenesis GO:0050768 9.81 IL1B IL6 TNF
26 regulation of signaling receptor activity GO:0010469 9.81 CCL2 IFNA6 IFNB1 IL10 IL17A IL1B
27 positive regulation of glial cell proliferation GO:0060252 9.8 IL1B IL6 TNF
28 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TLR9 TNF
29 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR4 TLR9 TNF
30 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 ICAM1 IL10 IL1B IL6 TLR4
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 IL10 IL1B TNF
32 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR4 TLR9 TNF
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.77 CCL2 TLR4 TLR9
34 humoral immune response GO:0006959 9.77 CCL2 IFNA6 IFNB1 IL6 TNF
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.76 TLR4 TLR9 TNF
36 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR4 TLR9 TNF
37 negative regulation of lipid storage GO:0010888 9.74 CRP IL6 TNF
38 I-kappaB phosphorylation GO:0007252 9.73 TLR4 TLR9
39 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR9
40 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B TLR9
41 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
42 neutrophil mediated immunity GO:0002446 9.72 ACE IL6
43 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 IL4 TLR4
45 positive regulation of interferon-beta biosynthetic process GO:0045359 9.71 TLR4 TLR9
46 negative regulation of interleukin-8 production GO:0032717 9.71 IL10 TLR9
47 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.7 IL10 TNF
49 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.7 ICAM1 TNF
50 positive regulation of fever generation GO:0031622 9.69 IL1B TNF

Molecular functions related to Extrinsic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNA6 IFNB1 IL10 IL17A IL1B
2 cytokine receptor binding GO:0005126 9.13 IFNA6 IFNB1 IL4

Sources for Extrinsic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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