MCID: EXD002
MIFTS: 30

Exudative Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Exudative Glomerulonephritis

MalaCards integrated aliases for Exudative Glomerulonephritis:

Name: Exudative Glomerulonephritis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4777
NCIt 51 C35706
UMLS 74 C0546345

Summaries for Exudative Glomerulonephritis

MalaCards based summary : Exudative Glomerulonephritis is related to dermatitis, atopic and pulmonary disease, chronic obstructive. An important gene associated with Exudative Glomerulonephritis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. Affiliated tissues include lung, bone and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Exudative Glomerulonephritis

Diseases related to Exudative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 10.1 CXCL8 TNF
2 pulmonary disease, chronic obstructive 10.1 CXCL8 TNF
3 hemophagocytic lymphohistiocytosis 10.1 CXCL8 TNF
4 tungiasis 10.1 CXCL8 TNF
5 streptococcal toxic-shock syndrome 10.1 CXCL8 TNF
6 cardiac sarcoidosis 10.1 CXCL8 TNF
7 clonorchiasis 10.1 CXCL8 TNF
8 meconium aspiration syndrome 10.1 CXCL8 TNF
9 mycobacterium abscessus 10.1 CXCL8 TNF
10 louse-borne relapsing fever 10.1 CXCL8 TNF
11 periodontosis 10.1 CXCL8 TNF
12 transverse myelitis 10.1 CXCL8 TNF
13 pleural tuberculosis 10.1 CXCL8 TNF
14 tuberculous meningitis 10.1 CXCL8 TNF
15 glaucomatocyclitic crisis 10.1 CXCL8 TNF
16 pyoderma gangrenosum 10.1 CXCL8 TNF
17 pyoderma 10.1 CXCL8 TNF
18 bacterial sepsis 10.1 CXCL8 TNF
19 fasciitis 10.1 CXCL8 TNF
20 keratoconjunctivitis 10.1 CXCL8 TNF
21 hemorrhagic fever with renal syndrome 10.1 CXCL8 TNF
22 pleurisy 10.1 CXCL8 TNF
23 nose disease 10.1 CXCL8 TNF
24 avian influenza 10.0 CXCL8 TNF
25 brucellosis 10.0 CXCL8 TNF
26 severe acute respiratory syndrome 10.0 CXCL8 TNF
27 bronchiolitis obliterans 10.0 CXCL8 TNF
28 bronchiolitis 10.0 CXCL8 TNF
29 adult respiratory distress syndrome 10.0 CXCL8 TNF
30 dengue hemorrhagic fever 10.0 CXCL8 TNF
31 obstructive jaundice 10.0 CXCL8 TNF
32 spinal cord injury 10.0 CXCL8 TNF
33 psoriatic arthritis 10.0 IL1B TNF
34 glomerulonephritis 10.0
35 osteoarthritis 10.0 IL1B TNF
36 bone disease 10.0 IL1B TNF
37 central nervous system disease 10.0 IL1B TNF
38 endocarditis 10.0 CXCL8 TNF
39 nervous system disease 10.0 IL1B TNF
40 alcoholic hepatitis 10.0 CXCL8 TNF
41 cystitis 10.0 CXCL8 TNF
42 visceral leishmaniasis 10.0 CXCL8 TNF
43 staphylococcal toxic shock syndrome 10.0 IL1B TNF
44 kashin-beck disease 10.0 IL1B TNF
45 vulvar vestibulitis syndrome 10.0 IL1B TNF
46 burns 10.0 IL1B TNF
47 glossitis 10.0 IL1B TNF
48 laryngitis 10.0 IL1B TNF
49 cerebral artery occlusion 10.0 IL1B TNF
50 retinitis pigmentosa 60 10.0 IL1B TNF

Graphical network of the top 20 diseases related to Exudative Glomerulonephritis:



Diseases related to Exudative Glomerulonephritis

Symptoms & Phenotypes for Exudative Glomerulonephritis

GenomeRNAi Phenotypes related to Exudative Glomerulonephritis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CXCL8 IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CXCL8 IL1B TNF
3 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.96 CXCL8 TNF

Drugs & Therapeutics for Exudative Glomerulonephritis

Search Clinical Trials , NIH Clinical Center for Exudative Glomerulonephritis

Genetic Tests for Exudative Glomerulonephritis

Anatomical Context for Exudative Glomerulonephritis

MalaCards organs/tissues related to Exudative Glomerulonephritis:

42
Lung, Bone, Liver, Heart, Lymph Node, Spinal Cord, Placenta

Publications for Exudative Glomerulonephritis

Articles related to Exudative Glomerulonephritis:

# Title Authors Year
1
Evolution of membranous nephropathy from a proliferative and exudative glomerulonephritis--a report of three cases studied by serial biopsies. ( 3897088 )
1985
2
Eosinophilic leukocytes in diffuse proliferative and exudative glomerulonephritis. ( 907041 )
1977

Variations for Exudative Glomerulonephritis

Expression for Exudative Glomerulonephritis

Search GEO for disease gene expression data for Exudative Glomerulonephritis.

Pathways for Exudative Glomerulonephritis

Pathways related to Exudative Glomerulonephritis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 CXCL8 IL1B TNF
2
Show member pathways
12.95 CXCL8 IL1B TNF
3
Show member pathways
12.78 CXCL8 IL1B TNF
4
Show member pathways
12.65 CXCL8 IL1B TNF
5
Show member pathways
12.58 CXCL8 IL1B TNF
6
Show member pathways
12.48 CXCL8 IL1B TNF
7
Show member pathways
12.08 CXCL8 IL1B TNF
8
Show member pathways
12.05 CXCL8 IL1B TNF
9
Show member pathways
11.99 CXCL8 IL1B TNF
10
Show member pathways
11.97 CXCL8 IL1B TNF
11
Show member pathways
11.95 IL1B TNF
12
Show member pathways
11.95 IL1B TNF
13
Show member pathways
11.93 CXCL8 IL1B TNF
14 11.91 CXCL8 IL1B TNF
15 11.85 IL1B TNF
16
Show member pathways
11.82 IL1B TNF
17 11.81 IL1B TNF
18
Show member pathways
11.8 IL1B TNF
19 11.77 CXCL8 IL1B TNF
20 11.74 IL1B TNF
21 11.73 CXCL8 IL1B TNF
22 11.72 CXCL8 IL1B
23 11.68 IL1B TNF
24 11.65 CXCL8 IL1B TNF
25 11.62 CXCL8 IL1B
26 11.62 CXCL8 IL1B TNF
27 11.61 CXCL8 IL1B TNF
28 11.59 IL1B TNF
29
Show member pathways
11.56 CXCL8 TNF
30 11.54 IL1B TNF
31 11.54 CXCL8 IL1B TNF
32 11.52 IL1B TNF
33 11.43 CXCL8 IL1B TNF
34 11.34 IL1B TNF
35 11.34 IL1B TNF
36 11.3 IL1B TNF
37 11.3 CXCL8 IL1B TNF
38
Show member pathways
11.28 IL1B TNF
39
Show member pathways
11.23 CXCL8 IL1B TNF
40 11.21 IL1B TNF
41 11.18 IL1B TNF
42 11.13 IL1B TNF
43 11.11 IL1B TNF
44 11.08 IL1B TNF
45 11.07 CXCL8 IL1B TNF
46 10.99 CXCL8 TNF
47 10.96 CXCL8 IL1B TNF
48 10.94 IL1B TNF
49 10.87 CXCL8 TNF
50 10.82 CXCL8 IL1B TNF

GO Terms for Exudative Glomerulonephritis

Biological processes related to Exudative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 CXCL8 IL1B TNF
2 regulation of signaling receptor activity GO:0010469 9.77 CXCL8 IL1B TNF
3 inflammatory response GO:0006954 9.75 CXCL8 IL1B TNF
4 cytokine-mediated signaling pathway GO:0019221 9.71 CXCL8 IL1B TNF
5 positive regulation of angiogenesis GO:0045766 9.68 CXCL8 IL1B
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.68 IL1B TNF
7 defense response GO:0006952 9.68 CXCL8 TNF
8 activation of MAPK activity GO:0000187 9.67 IL1B TNF
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.67 IL1B TNF
10 neutrophil chemotaxis GO:0030593 9.67 CXCL8 IL1B
11 positive regulation of JNK cascade GO:0046330 9.66 IL1B TNF
12 cellular response to organic cyclic compound GO:0071407 9.66 IL1B TNF
13 regulation of insulin secretion GO:0050796 9.65 IL1B TNF
14 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B TNF
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.64 IL1B TNF
16 positive regulation of interferon-gamma production GO:0032729 9.64 IL1B TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IL1B TNF
18 positive regulation of phagocytosis GO:0050766 9.62 IL1B TNF
19 protein kinase B signaling GO:0043491 9.61 IL1B TNF
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.61 IL1B TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.6 IL1B TNF
22 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TNF
23 cellular response to lipopolysaccharide GO:0071222 9.58 CXCL8 IL1B TNF
24 negative regulation of neurogenesis GO:0050768 9.57 IL1B TNF
25 embryonic digestive tract development GO:0048566 9.55 CXCL8 TNF
26 negative regulation of lipid catabolic process GO:0050995 9.52 IL1B TNF
27 positive regulation of glial cell proliferation GO:0060252 9.51 IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.49 IL1B TNF
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 IL1B TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.46 IL1B TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.43 IL1B TNF
32 regulation of establishment of endothelial barrier GO:1903140 9.37 IL1B TNF
33 response to glucocorticoid GO:0051384 9.35 TNF
34 positive regulation of JUN kinase activity GO:0043507 9.32 TNF
35 positive regulation of neuroinflammatory response GO:0150078 9.32 IL1B TNF
36 positive regulation of neutrophil chemotaxis GO:0090023 9.26 CXCL8
37 positive regulation of fever generation GO:0031622 9.26 IL1B TNF
38 sequestering of triglyceride GO:0030730 8.96 IL1B TNF
39 chronic inflammatory response to antigenic stimulus GO:0002439 8.85 TNF
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IL1B TNF

Molecular functions related to Exudative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B TNF

Sources for Exudative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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50 NCI
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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