MCID: EYC003
MIFTS: 18

Eye Accommodation Disease

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Eye Accommodation Disease

MalaCards integrated aliases for Eye Accommodation Disease:

Name: Eye Accommodation Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10034
ICD9CM 34 367.5
SNOMED-CT 67 155137002
ICD10 32 H52.5
UMLS 70 C0152198

Summaries for Eye Accommodation Disease

Disease Ontology : 12 An eye disease that is characterized by decreased ability to change the optical power of the eye to maintain a clear image.

MalaCards based summary : Eye Accommodation Disease is related to cycloplegia and retinal perforation. An important gene associated with Eye Accommodation Disease is CRYAA (Crystallin Alpha A). Affiliated tissues include eye, and related phenotype is vision/eye.

Related Diseases for Eye Accommodation Disease

Diseases related to Eye Accommodation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 cycloplegia 31.5 SLC5A7 KERA IRX6 IRX3
2 retinal perforation 10.3 CRYGS CRYAA
3 cataract 31, multiple types 10.3 CRYAA BFSP1
4 corneal dystrophy, avellino type 10.3 CRYAA BFSP2
5 cataract 24 10.2 CRYGB CRYAA
6 mature cataract 10.2 MIP CRYGS CRYAA
7 lateral displacement of eye 10.2 IRX6 IRX3
8 early-onset sutural cataract 10.2 MIP CRYGS BFSP2
9 cataract 48 10.2 CRYGB CRYAA
10 transient refractive change 10.2 IRX6 IRX3
11 senile cataract 10.2 CRYGS CRYAA BFSP1
12 early-onset nuclear cataract 10.2 MIP CRYAA BFSP1
13 posterior polar cataract 10.2 CRYAA BFSP2 BFSP1
14 abruzzo-erickson syndrome 10.2 CRYGB CRYAA
15 lens subluxation 10.2 CRYAA BFSP1
16 cornea plana 10.2 KERA CRYAA
17 diabetic cataract 10.2 CRYGS CRYAA
18 immature cataract 10.2 MIP CRYGB CRYAA
19 morgagni cataract 10.2 CRYGS CRYGB CRYAA
20 night blindness, congenital stationary, type 2a 10.2 CRYGB CRYAA
21 nuclear senile cataract 10.1 CRYGS CRYGB BFSP1
22 axenfeld-rieger syndrome, type 1 10.1 FOXE3 CRYAA
23 lacrimal apparatus disease 10.1 CRYAA AQP5
24 axenfeld-rieger syndrome 10.1 FOXE3 CRYGS CRYAA
25 sclerocornea 10.1 FOXE3 CRYAA
26 disuse amblyopia 10.1 FOXE3 CRYGS CRYAA
27 aniridia 1 10.0 FOXE3 CRYAA BFSP1
28 juvenile glaucoma 10.0 KERA FOXE3 CRYAA
29 congenital aphakia 10.0 FOXE3 CRYGB CRYAA
30 corneal disease 10.0 KERA FOXE3 CRYAA
31 keratitis, hereditary 10.0 KERA FOXE3 CRYAA
32 aniseikonia 10.0 IRX6 IRX3 FOXE3
33 nance-horan syndrome 10.0 CRYAA BFSP2
34 early-onset lamellar cataract 9.9 MIP CRYGS CRYGB CRYAA BFSP2
35 iris disease 9.9 FOXE3 CRYAA
36 cataract 44 9.8 MIP LIM2 CRYGB CRYAA
37 amblyopia 9.8 FOXE3 CRYGS CRYAA BFSP2 BFSP1
38 anterior segment dysgenesis 9.8 KERA FOXE3 CRYAA BFSP2 BFSP1
39 galactosemia ii 9.8 LIM2 CRYGS CRYAA BFSP2 BFSP1
40 lens disease 9.5 MIP FOXE3 CRYGS CRYGB CRYAA BFSP2
41 axenfeld-rieger syndrome, type 3 9.5 LIM2 FOXE3 CRYGS CRYAA BFSP2 BFSP1
42 early-onset non-syndromic cataract 9.3 MIP LIM2 FOXE3 CRYGS CRYGB BFSP2
43 cataract 9.0 MIP LIM2 FOXE3 CRYGS CRYGB CRYAA
44 presbyopia 8.0 SCARNA16 MIP LIM2 LCTL HCFC1 CRYGS

Graphical network of the top 20 diseases related to Eye Accommodation Disease:



Diseases related to Eye Accommodation Disease

Symptoms & Phenotypes for Eye Accommodation Disease

MGI Mouse Phenotypes related to Eye Accommodation Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.4 AQP5 BFSP1 BFSP2 CRYGB CRYGS IRX3

Drugs & Therapeutics for Eye Accommodation Disease

Search Clinical Trials , NIH Clinical Center for Eye Accommodation Disease

Genetic Tests for Eye Accommodation Disease

Anatomical Context for Eye Accommodation Disease

MalaCards organs/tissues related to Eye Accommodation Disease:

40
Eye

Publications for Eye Accommodation Disease

Variations for Eye Accommodation Disease

Expression for Eye Accommodation Disease

Search GEO for disease gene expression data for Eye Accommodation Disease.

Pathways for Eye Accommodation Disease

GO Terms for Eye Accommodation Disease

Cellular components related to Eye Accommodation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 SLC5A7 IRX3 HCFC1 CPNE6

Biological processes related to Eye Accommodation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.77 MIP LCTL KERA CRYAA BFSP2
2 cell maturation GO:0048469 9.46 BFSP2 BFSP1
3 intermediate filament organization GO:0045109 9.43 BFSP2 BFSP1
4 cell development GO:0048468 9.43 IRX6 IRX3 FOXE3
5 water transport GO:0006833 9.4 MIP AQP5
6 lens development in camera-type eye GO:0002088 9.35 MIP LIM2 FOXE3 CRYGS CRYGB
7 lens fiber cell development GO:0070307 9.33 CRYGB BFSP2 BFSP1
8 cornea development in camera-type eye GO:0061303 9.32 KERA FOXE3
9 visual perception GO:0007601 9.17 MIP LCTL KERA CRYGS CRYGB CRYAA

Molecular functions related to Eye Accommodation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.17 MIP LIM2 CRYGS CRYGB CRYAA BFSP2
2 channel activity GO:0015267 9.16 MIP AQP5
3 water channel activity GO:0015250 8.96 MIP AQP5

Sources for Eye Accommodation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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