Eye Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Eye Lymphoma

MalaCards integrated aliases for Eye Lymphoma:

Name: Eye Lymphoma ¹² ¹⁵

Lymphoma of Eye ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Eye diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6903

NCIt ⁴⁹ C35690

UMLS ⁷¹ C1333519

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Summaries for Eye Lymphoma

Disease Ontology : ¹² A lymphoma by site that is manifested in immune system cells called lymphocytes.

MalaCards based summary : Eye Lymphoma, also known as lymphoma of eye, is related to acute transverse myelitis and transverse myelitis. An important gene associated with Eye Lymphoma is IGHV4-38-2 (Immunoglobulin Heavy Variable 4-38-2), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include eye, b cells and bone, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Eye Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma

Eye Lymphoma

Diseases related to Eye Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)

#	Related Disease	Score	Top Affiliating Genes
1	acute transverse myelitis	10.4	IL6 IL10
2	transverse myelitis	10.4	IL6 IL10
3	post-transplant lymphoproliferative disease	10.4	IL6 IL10
4	eales disease	10.4	IL6 IL10
5	bone sarcoma	10.4	IL6 IL10
6	traumatic brain injury	10.3	IL6 IL10
7	brain injury	10.3	IL6 IL10
8	chlamydia pneumonia	10.3	IL6 IL10
9	idiopathic neutropenia	10.3	IL6 IL10
10	chorioretinitis	10.3	IL6 IL10
11	hyper ige recurrent infection syndrome 1	10.3	IL6 IL10
12	fungal meningitis	10.3	IL6 IL10
13	mental retardation, autosomal dominant 33	10.3	IGHV4-38-2 CD22
14	african tick-bite fever	10.3	IL6 IL10
15	orchitis	10.3	IL6 IL10
16	chronic conjunctivitis	10.3	IL6 IL10
17	viral pneumonia	10.3	IL6 IL10
18	funisitis	10.3	IL6 IL10
19	autoimmune disease of eyes, ear, nose and throat	10.3	IL6 IL10
20	primary systemic mycosis	10.3	IL6 IL10
21	human herpesvirus 8	10.2	IL6 BCL6
22	primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma	10.2	CXCR5 BCL6
23	cysticercosis	10.2	IL6 IL10
24	lymphosarcoma	10.2	CD22 BCL6
25	bronchopneumonia	10.2	IL6 IL10
26	thyrotoxic exophthalmos	10.2	IL6 CD5
27	combined thymoma	10.1	IL10 CD5
28	appendix lymphoma	10.1	IGHV4-38-2 CD5
29	childhood type dermatomyositis	10.1	IL6 CXCR5
30	acute myocarditis	10.1	IL6 IL10
31	endocrine exophthalmos	10.1	IL6 CD5
32	nasal cavity lymphoma	10.1	IGHV4-38-2 CD5
33	relapsing polychondritis	10.1	IL6 IL10
34	orofaciodigital syndrome viii	10.1	IGHV4-38-2 BCL6
35	chromosome 13q14 deletion syndrome	10.1	IGHV4-38-2 CD5
36	uveitis	10.1	IL6 IL10 CXCR5
37	pediatric lymphoma	10.1	IGHV4-38-2 CD22 BCL6
38	cystic echinococcosis	10.0	IL6 IL10
39	retina lymphoma	10.0	TRPV2 IGHV4-38-2 CXCL13
40	bladder lymphoma	10.0	CD5 BCL6
41	prostate lymphoma	10.0	CD5 BCL6
42	epiglottis neoplasm	10.0	CD5 BCL6
43	liver lymphoma	10.0	CD5 BCL6
44	bone lymphoma	10.0	CD5 BCL6
45	colon lymphoma	10.0	CD5 BCL6
46	intravascular large b-cell lymphoma	10.0	CD5 BCL6
47	lung lymphoma	10.0	CD5 BCL6
48	breast lymphoma	10.0	CD5 BCL6
49	gastrointestinal lymphoma	10.0	CD5 BCL6
50	autoimmune lymphoproliferative syndrome, type v	10.0	CD5 BCL6

Graphical network of the top 20 diseases related to Eye Lymphoma:

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Symptoms & Phenotypes for Eye Lymphoma

MGI Mouse Phenotypes related to Eye Lymphoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.76	BCL6 CD19 CD22 CXCL13 CXCR5 IL10
2	hematopoietic system	MP:0005397	9.61	BCL6 CD19 CD22 CD5 CXCL13 CXCR5
3	immune system	MP:0005387	9.28	BCL6 CD19 CD22 CD5 CXCL13 CXCR5

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Drugs & Therapeutics for Eye Lymphoma

Search Clinical Trials , NIH Clinical Center for Eye Lymphoma

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Genetic Tests for Eye Lymphoma

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Anatomical Context for Eye Lymphoma

MalaCards organs/tissues related to Eye Lymphoma:

⁴⁰

Eye, B Cells, Bone, T Cells, Brain, Spinal Cord, Breast

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Publications for Eye Lymphoma

Articles related to Eye Lymphoma:

#	Title	Authors	PMID	Year
1	A salmon-colored mass seen subconjunctivally on the left eye. Lymphoma. ⁶¹	Servodidio CA...Abramson DH	8301685	1993

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Genes for Eye Lymphoma

Genes related to Eye Lymphoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGHV4-38-2	Immunoglobulin Heavy Variable 4-38-2	Protein Coding	7.31	DISEASES inferred ¹⁵
2	IL10	Interleukin 10	Protein Coding	6.61	DISEASES inferred ¹⁵
3	IL6	Interleukin 6	Protein Coding	6.03	DISEASES inferred ¹⁵
4	TRPV2	Transient Receptor Potential Cation Channel Subfamily V Member 2	Protein Coding	5.95	DISEASES inferred ¹⁵
5	CD22	CD22 Molecule	Protein Coding	5.92	DISEASES inferred ¹⁵
6	PTPRK	Protein Tyrosine Phosphatase Receptor Type K	Protein Coding	5.88	DISEASES inferred ¹⁵
7	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	5.84	DISEASES inferred ¹⁵
8	BCL6	BCL6 Transcription Repressor	Protein Coding	5.61	DISEASES inferred ¹⁵
9	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	5.56	DISEASES inferred ¹⁵
10	CD5	CD5 Molecule	Protein Coding	5.55	DISEASES inferred ¹⁵
11	CD19	CD19 Molecule	Protein Coding	5.48	DISEASES inferred ¹⁵
12	DPH7	Diphthamide Biosynthesis 7	Protein Coding	5.46	DISEASES inferred ¹⁵

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Variations for Eye Lymphoma

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Expression for Eye Lymphoma

Search GEO for disease gene expression data for Eye Lymphoma.

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Pathways for Eye Lymphoma

Pathways related to Eye Lymphoma according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.52	IL6 IL10 CXCR5 CXCL13
2	NF-kappaB Signaling ⁴	12.22	IL10 CXCR5 CD19 BCL6
3	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	11.89	IL6 IL10 CXCR5 CXCL13
4	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.77	IL6 IL10 BCL6
5	Interleukin-4 and 13 signaling ⁶⁵	11.67	IL6 IL10 BCL6
6	Hematopoietic cell lineage ³⁶	11.45	IL6 CD5 CD22 CD19
7	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.42	IL6 IL10 CD5 CD22 CD19
8	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.41	IL6 IL10 CD19
9	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁴	11.35	IL6 IL10 CXCL13
10	Cytokines and Inflammatory Response ¹	10.96	IL6 IL10
11	B Cell Development Pathways ⁶⁴	10.82	IL10 CXCR5 CD5 CD22 CD19 BCL6

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GO Terms for Eye Lymphoma

Cellular components related to Eye Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.92	IGHV4-38-2 CXCR5 CD5 CD19

Biological processes related to Eye Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.67	IL6 IL10 CXCR5 CXCL13
2	negative regulation of cell proliferation	GO:0008285	9.62	PTPRK IL6 IL10 BCL6
3	cellular response to lipopolysaccharide	GO:0071222	9.58	IL6 IL10 CXCL13
4	inflammatory response	GO:0006954	9.56	IL6 IL10 CXCL13 BCL6
5	positive regulation of JAK-STAT cascade	GO:0046427	9.43	IL6 IL10
6	germinal center formation	GO:0002467	9.16	CXCL13 BCL6
7	type 2 immune response	GO:0042092	8.96	IL10 BCL6
8	leukocyte chemotaxis	GO:0030595	8.8	IL10 CXCR5 CXCL13

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Sources for Eye Lymphoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia