MCID: EYL003
MIFTS: 27

Eye Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Rare diseases

Aliases & Classifications for Eye Lymphoma

MalaCards integrated aliases for Eye Lymphoma:

Name: Eye Lymphoma 12 15
Lymphoma of Eye 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6903
NCIt 49 C35690
UMLS 71 C1333519

Summaries for Eye Lymphoma

Disease Ontology : 12 A lymphoma by site that is manifested in immune system cells called lymphocytes.

MalaCards based summary : Eye Lymphoma, also known as lymphoma of eye, is related to acute transverse myelitis and transverse myelitis. An important gene associated with Eye Lymphoma is IGHV4-38-2 (Immunoglobulin Heavy Variable 4-38-2), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include eye, b cells and bone, and related phenotypes are cellular and hematopoietic system

Related Diseases for Eye Lymphoma

Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Eye Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 acute transverse myelitis 10.4 IL6 IL10
2 transverse myelitis 10.4 IL6 IL10
3 post-transplant lymphoproliferative disease 10.4 IL6 IL10
4 eales disease 10.4 IL6 IL10
5 bone sarcoma 10.4 IL6 IL10
6 traumatic brain injury 10.3 IL6 IL10
7 brain injury 10.3 IL6 IL10
8 chlamydia pneumonia 10.3 IL6 IL10
9 idiopathic neutropenia 10.3 IL6 IL10
10 chorioretinitis 10.3 IL6 IL10
11 hyper ige recurrent infection syndrome 1 10.3 IL6 IL10
12 fungal meningitis 10.3 IL6 IL10
13 mental retardation, autosomal dominant 33 10.3 IGHV4-38-2 CD22
14 african tick-bite fever 10.3 IL6 IL10
15 orchitis 10.3 IL6 IL10
16 chronic conjunctivitis 10.3 IL6 IL10
17 viral pneumonia 10.3 IL6 IL10
18 funisitis 10.3 IL6 IL10
19 autoimmune disease of eyes, ear, nose and throat 10.3 IL6 IL10
20 primary systemic mycosis 10.3 IL6 IL10
21 human herpesvirus 8 10.2 IL6 BCL6
22 primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma 10.2 CXCR5 BCL6
23 cysticercosis 10.2 IL6 IL10
24 lymphosarcoma 10.2 CD22 BCL6
25 bronchopneumonia 10.2 IL6 IL10
26 thyrotoxic exophthalmos 10.2 IL6 CD5
27 combined thymoma 10.1 IL10 CD5
28 appendix lymphoma 10.1 IGHV4-38-2 CD5
29 childhood type dermatomyositis 10.1 IL6 CXCR5
30 acute myocarditis 10.1 IL6 IL10
31 endocrine exophthalmos 10.1 IL6 CD5
32 nasal cavity lymphoma 10.1 IGHV4-38-2 CD5
33 relapsing polychondritis 10.1 IL6 IL10
34 orofaciodigital syndrome viii 10.1 IGHV4-38-2 BCL6
35 chromosome 13q14 deletion syndrome 10.1 IGHV4-38-2 CD5
36 uveitis 10.1 IL6 IL10 CXCR5
37 pediatric lymphoma 10.1 IGHV4-38-2 CD22 BCL6
38 cystic echinococcosis 10.0 IL6 IL10
39 retina lymphoma 10.0 TRPV2 IGHV4-38-2 CXCL13
40 bladder lymphoma 10.0 CD5 BCL6
41 prostate lymphoma 10.0 CD5 BCL6
42 epiglottis neoplasm 10.0 CD5 BCL6
43 liver lymphoma 10.0 CD5 BCL6
44 bone lymphoma 10.0 CD5 BCL6
45 colon lymphoma 10.0 CD5 BCL6
46 intravascular large b-cell lymphoma 10.0 CD5 BCL6
47 lung lymphoma 10.0 CD5 BCL6
48 breast lymphoma 10.0 CD5 BCL6
49 gastrointestinal lymphoma 10.0 CD5 BCL6
50 autoimmune lymphoproliferative syndrome, type v 10.0 CD5 BCL6

Graphical network of the top 20 diseases related to Eye Lymphoma:



Diseases related to Eye Lymphoma

Symptoms & Phenotypes for Eye Lymphoma

MGI Mouse Phenotypes related to Eye Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 BCL6 CD19 CD22 CXCL13 CXCR5 IL10
2 hematopoietic system MP:0005397 9.61 BCL6 CD19 CD22 CD5 CXCL13 CXCR5
3 immune system MP:0005387 9.28 BCL6 CD19 CD22 CD5 CXCL13 CXCR5

Drugs & Therapeutics for Eye Lymphoma

Search Clinical Trials , NIH Clinical Center for Eye Lymphoma

Genetic Tests for Eye Lymphoma

Anatomical Context for Eye Lymphoma

MalaCards organs/tissues related to Eye Lymphoma:

40
Eye, B Cells, Bone, T Cells, Brain, Spinal Cord, Breast

Publications for Eye Lymphoma

Articles related to Eye Lymphoma:

# Title Authors PMID Year
1
A salmon-colored mass seen subconjunctivally on the left eye. Lymphoma. 61
8301685 1993

Variations for Eye Lymphoma

Expression for Eye Lymphoma

Search GEO for disease gene expression data for Eye Lymphoma.

Pathways for Eye Lymphoma

GO Terms for Eye Lymphoma

Cellular components related to Eye Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IGHV4-38-2 CXCR5 CD5 CD19

Biological processes related to Eye Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 IL6 IL10 CXCR5 CXCL13
2 negative regulation of cell proliferation GO:0008285 9.62 PTPRK IL6 IL10 BCL6
3 cellular response to lipopolysaccharide GO:0071222 9.58 IL6 IL10 CXCL13
4 inflammatory response GO:0006954 9.56 IL6 IL10 CXCL13 BCL6
5 positive regulation of JAK-STAT cascade GO:0046427 9.43 IL6 IL10
6 germinal center formation GO:0002467 9.16 CXCL13 BCL6
7 type 2 immune response GO:0042092 8.96 IL10 BCL6
8 leukocyte chemotaxis GO:0030595 8.8 IL10 CXCR5 CXCL13

Sources for Eye Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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