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MCID: EYL003
MIFTS: 33

Eye Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Neuronal diseases
Genes Tissues Related diseases Pathways Drugs
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Aliases & Classifications for Eye Lymphoma

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MalaCards integrated aliases for Eye Lymphoma:

Name: Eye Lymphoma 12 15
Lymphoma of Eye 74

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6903
NCIt 51 C35690
UMLS 74 C1333519
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Summaries for Eye Lymphoma

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Disease Ontology : 12 A lymphoma by site that is manifested in immune system cells called lymphocytes.

MalaCards based summary : Eye Lymphoma, also known as lymphoma of eye, is related to acute transverse myelitis and transverse myelitis. An important gene associated with Eye Lymphoma is IL10 (Interleukin 10), and among its related pathways/superpathways are NF-kappaB Signaling and FoxO signaling pathway. The drugs Dexamethasone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include eye, b cells and brain.

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Related Diseases for Eye Lymphoma

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Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Eye Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 acute transverse myelitis 10.3 IL10 IL6
2 transverse myelitis 10.3 IL10 IL6
3 funisitis 10.3 IL10 IL6
4 autoimmune gastritis 10.3 IL10 IL6
5 cystic echinococcosis 10.3 IL10 IL6
6 echinococcosis 10.3 IL10 IL6
7 autoimmune disease of eyes, ear, nose and throat 10.3 IL10 IL6
8 intermediate uveitis 10.3 IL10 IL6
9 post-transplant lymphoproliferative disease 10.3 IL10 IL6
10 hand, foot and mouth disease 10.3 IL10 IL6
11 mycoplasma pneumoniae pneumonia 10.3 IL10 IL6
12 radiculopathy 10.3 IL10 IL6
13 eales disease 10.3 IL10 IL6
14 traumatic brain injury 10.3 IL10 IL6
15 brain injury 10.3 IL10 IL6
16 hematopoietic stem cell transplantation 10.2 IL10 IL6
17 plasmodium vivax malaria 10.2 IL10 IL6
18 acute pyelonephritis 10.2 IL10 IL6
19 pyelonephritis 10.2 IL10 IL6
20 lacrimal apparatus disease 10.2 IL10 IL6
21 commensal bacterial infectious disease 10.2 IL10 IL6
22 q fever 10.2 IL10 IL6
23 complex regional pain syndrome 10.2 IL10 IL6
24 viral encephalitis 10.2 IL10 IL6
25 aphthous stomatitis 10.2 IL10 IL6
26 rheumatic fever 10.2 IL10 IL6
27 sporotrichosis 10.2 CD79A IL10
28 extrinsic cardiomyopathy 10.2 IL10 IL6
29 cow milk allergy 10.2 CD79A IL10
30 idiopathic neutropenia 10.2 IL10 IL6
31 milk allergy 10.2 CD79A IL10
32 spondyloarthropathy 10.2 IL10 IL6
33 prostatitis 10.2 IL10 IL6
34 chronic graft versus host disease 10.2 CD79A IL10
35 clonorchiasis 10.2 CD79A IL10
36 lymph node disease 10.2 IL10 IL6
37 paracoccidioidomycosis 10.2 IL10 IL6
38 mixed connective tissue disease 10.2 IL10 IL6
39 rheumatic heart disease 10.2 IL10 IL6
40 orofacial granulomatosis 10.2 CD79A IL10
41 uveal disease 10.2 IL10 IL6
42 melioidosis 10.2 IL10 IL6
43 leptospirosis 10.2 IL10 IL6
44 brucellosis 10.2 IL10 IL6
45 appendicitis 10.2 IL10 IL6
46 sleeping sickness 10.2 IL10 IL6
47 lipoid nephrosis 10.2 CD79A IL10
48 tropical spastic paraparesis 10.2 IL10 IL6
49 human immunodeficiency virus infectious disease 10.2 IL10 IL6
50 bronchiolitis 10.2 IL10 IL6

Graphical network of the top 20 diseases related to Eye Lymphoma:



Diseases related to Eye Lymphoma
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Symptoms & Phenotypes for Eye Lymphoma

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Drugs & Therapeutics for Eye Lymphoma

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Drugs for Eye Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
leucovorin Approved Phase 2 58-05-9 143 6006
3
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
4
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
5
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8
Doxil Approved June 1999 Phase 2 31703
9 Autonomic Agents Phase 2
10 Hormone Antagonists Phase 2
11 Dermatologic Agents Phase 2
12 Anti-Bacterial Agents Phase 2
13 Peripheral Nervous System Agents Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2
15 Antiemetics Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Antimetabolites, Antineoplastic Phase 2
18 Vitamin B9 Phase 2
19 Gastrointestinal Agents Phase 2
20 Antirheumatic Agents Phase 2
21 Anti-Infective Agents Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Vitamin B Complex Phase 2
24 Immunologic Factors Phase 2
25 Antiviral Agents Phase 2
26 Hormones Phase 2
27 Antimetabolites Phase 2
28 Folic Acid Antagonists Phase 2
29 glucocorticoids Phase 2
30 Immunosuppressive Agents Phase 2
31 Antibiotics, Antitubercular Phase 2
32 Topoisomerase Inhibitors Phase 2
33 BB 1101 Phase 2
34 Folate Phase 2
35 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / or High-dose Cytarabine. Terminated NCT01848652 Phase 2 infusion of MYOCET

Search NIH Clinical Center for Eye Lymphoma

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Genetic Tests for Eye Lymphoma

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Anatomical Context for Eye Lymphoma

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MalaCards organs/tissues related to Eye Lymphoma:

42
Eye, B Cells, Brain, Colon, Bone, Heart, Lymph Node
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Publications for Eye Lymphoma

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Variations for Eye Lymphoma

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Expression for Eye Lymphoma

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Search GEO for disease gene expression data for Eye Lymphoma.
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Pathways for Eye Lymphoma

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Pathways related to Eye Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
12.12 BCL6 CD79A IL10
2
FoxO signaling pathway 38
Show member pathways
 11.57 BCL6 IL10 IL6
3
Dendritic Cells Developmental Lineage Pathway 66
11.39 IL10 IL6
4
Interleukin-4 and 13 signaling 67
11.39 BCL6 IL10 IL6
5
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.36 IL10 IL6
6
IL4-mediated signaling events 1
11.29 BCL6 IL10
7
Interleukin-10 signaling 67
11.17 IL10 IL6
8
Malaria 38
11.15 IL10 IL6
9
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.99 CD5 CD79A IL10 IL6
10
African trypanosomiasis 38
10.97 IL10 IL6
11
IL-10 Pathway 65
10.91 IL10 IL6
12
B Cell Development Pathways 66
10.86 BCL6 CD5 IL10
13
Cytokines and Inflammatory Response 1
10.78 IL10 IL6
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GO Terms for Eye Lymphoma

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Biological processes related to Eye Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 BCL6 IL10 IL6
2 cytokine-mediated signaling pathway GO:0019221 9.5 BCL6 IL10 IL6
3 negative regulation of cell proliferation GO:0008285 9.46 BCL6 IL10 IL6 PTPRK
4 response to glucocorticoid GO:0051384 9.4 IL10 IL6
5 B cell proliferation GO:0042100 9.26 CD79A IL10
6 B cell differentiation GO:0030183 9.13 BCL6 CD79A IL10
7 type 2 immune response GO:0042092 8.62 BCL6 IL10
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Sources for Eye Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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