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MCID: EYL003
MIFTS: 28

Eye Lymphoma

Categories: Blood diseases, Cancer diseases, Eye diseases, Immune diseases, Neuronal diseases
Genes Tissues Related diseases Pathways Drugs
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Aliases & Classifications for Eye Lymphoma

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MalaCards integrated aliases for Eye Lymphoma:

Name: Eye Lymphoma 12 15
Lymphoma of Eye 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6903
NCIt 50 C35690
UMLS 73 C1333519
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Summaries for Eye Lymphoma

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Disease Ontology : 12 A lymphoma by site that is manifested in immune system cells called lymphocytes.

MalaCards based summary : Eye Lymphoma, also known as lymphoma of eye, is related to mucocutaneous leishmaniasis and cutaneous leishmaniasis. An important gene associated with Eye Lymphoma is IL10 (Interleukin 10), and among its related pathways/superpathways are Tuberculosis and C-type lectin receptor signaling pathway. The drugs Dexamethasone acetate and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and brain.

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Related Diseases for Eye Lymphoma

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Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Eye Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 mucocutaneous leishmaniasis 10.2 IL10 TLR9
2 cutaneous leishmaniasis 10.2 IL10 TLR9
3 filarial elephantiasis 10.2 IL10 TLR9
4 coccidiosis 10.2 IL10 TLR9
5 genital herpes 10.2 IL10 TLR9
6 nasal cavity disease 10.1 IL10 TLR9
7 opportunistic mycosis 10.1 IL10 TLR9
8 nose disease 10.1 IL10 TLR9
9 respiratory allergy 10.1 IL10 TLR9
10 parasitic helminthiasis infectious disease 10.1 IL10 TLR9
11 parapsoriasis 10.1 CD5 TLR9
12 irritable bowel syndrome 10.1 IL10 TLR9
13 immune deficiency disease 10.1 IL10 TLR9
14 breast lymphoma 10.1 CD5 CFAP298
15 visceral leishmaniasis 10.1 IL10 TLR9
16 mediastinal cancer 10.1 CD5 CFAP298
17 aspergillosis 10.1 IL10 TLR9
18 lymphatic system disease 10.1 CD5 TLR9
19 plasmodium falciparum malaria 10.1 IL10 TLR9
20 acute transverse myelitis 10.0 IL10 IL6
21 transverse myelitis 10.0 IL10 IL6
22 funisitis 10.0 IL10 IL6
23 autoimmune gastritis 10.0 IL10 IL6
24 multicentric castleman disease 10.0 IL10 IL6
25 castleman disease 10.0 IL10 IL6
26 cystic echinococcosis 10.0 IL10 IL6
27 echinococcosis 10.0 IL10 IL6
28 intermediate uveitis 10.0 IL10 IL6
29 post-transplant lymphoproliferative disease 10.0 IL10 IL6
30 hand, foot and mouth disease 10.0 IL10 IL6
31 mycoplasma pneumoniae pneumonia 10.0 IL10 IL6
32 eales disease 10.0 IL10 IL6
33 hemorrhagic fever 10.0 IL10 IL6
34 traumatic brain injury 10.0 IL10 IL6
35 brain injury 10.0 IL10 IL6
36 hematopoietic stem cell transplantation 10.0 IL10 IL6
37 plasmodium vivax malaria 10.0 IL10 IL6
38 acute pyelonephritis 10.0 IL10 IL6
39 pyelonephritis 10.0 IL10 IL6
40 commensal bacterial infectious disease 10.0 IL10 IL6
41 q fever 10.0 IL10 IL6
42 complex regional pain syndrome 10.0 IL10 IL6
43 viral encephalitis 10.0 IL10 IL6
44 aphthous stomatitis 10.0 IL10 IL6
45 rheumatic fever 10.0 IL10 IL6
46 idiopathic neutropenia 10.0 IL10 IL6
47 prostatitis 10.0 IL10 IL6
48 viral pneumonia 10.0 IL6 TLR9
49 central nervous system vasculitis 10.0 IL6 TLR9
50 paracoccidioidomycosis 10.0 IL10 IL6

Graphical network of the top 20 diseases related to Eye Lymphoma:



Diseases related to Eye Lymphoma
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Symptoms & Phenotypes for Eye Lymphoma

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Drugs & Therapeutics for Eye Lymphoma

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Drugs for Eye Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
2
leucovorin Approved Phase 2 58-05-9 6006 143
3
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
4
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
5
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
6
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8
Doxil Approved June 1999 Phase 2 31703
9 Nucleic Acid Synthesis Inhibitors Phase 2
10
protease inhibitors Phase 2
11 BB 1101 Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
13 Vitamin B9 Phase 2
14 Hormones Phase 2
15 Peripheral Nervous System Agents Phase 2
16 Antiviral Agents Phase 2
17 Vitamin B Complex Phase 2
18 Antibiotics, Antitubercular Phase 2
19 Hormone Antagonists Phase 2
20 Dermatologic Agents Phase 2
21 Folic Acid Antagonists Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Autonomic Agents Phase 2
24 Immunosuppressive Agents Phase 2
25 Antimetabolites Phase 2
26 Antirheumatic Agents Phase 2
27 Antiemetics Phase 2
28 Anti-Bacterial Agents Phase 2
29 Topoisomerase Inhibitors Phase 2
30 Folate Phase 2
31 HIV Protease Inhibitors Phase 2
32 Immunologic Factors Phase 2
33 Gastrointestinal Agents Phase 2
34 glucocorticoids Phase 2
35 Antimetabolites, Antineoplastic Phase 2
36 Anti-Infective Agents Phase 2
37 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / or High-dose Cytarabine. Terminated NCT01848652 Phase 2 infusion of MYOCET

Search NIH Clinical Center for Eye Lymphoma

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Genetic Tests for Eye Lymphoma

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Anatomical Context for Eye Lymphoma

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MalaCards organs/tissues related to Eye Lymphoma:

41
Eye, Lung, Brain, Bone, Heart, Lymph Node, Breast
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Publications for Eye Lymphoma

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Variations for Eye Lymphoma

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Expression for Eye Lymphoma

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Search GEO for disease gene expression data for Eye Lymphoma.
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Pathways for Eye Lymphoma

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Pathways related to Eye Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Tuberculosis 37
11.83 IL10 IL6 TLR9
2
C-type lectin receptor signaling pathway 37
Show member pathways
 11.78 IL10 IL6 TLR9
3
Th1 Differentiation Pathway 65
Show member pathways
 11.61 IL10 IL6 TLR9
4
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.5 CD5 IL10 IL6
5
Pertussis 37
11.4 IL10 IL6
6
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.36 IL10 IL6
7
B Cell Development Pathways 65
11.22 CD5 IL10
8
Dendritic Cells Developmental Lineage Pathway 65
11.2 IL10 IL6 TLR9
9
Interleukin-10 signaling 66
11.17 IL10 IL6
10
IL-10 Pathway 64
11 IL10 IL6
11
Cytokines and Inflammatory Response 1
10.9 IL10 IL6
12
Malaria 37
10.82 IL10 IL6 TLR9
13
African trypanosomiasis 37
10.34 IL10 IL6 TLR9
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GO Terms for Eye Lymphoma

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Biological processes related to Eye Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 IL10 IL6 TLR9
2 negative regulation of cell proliferation GO:0008285 9.58 IL10 IL6 PTPRK
3 inflammatory response GO:0006954 9.5 IL10 IL6 TLR9
4 defense response to Gram-negative bacterium GO:0050829 9.48 IL6 TLR9
5 response to glucocorticoid GO:0051384 9.43 IL10 IL6
6 positive regulation of interleukin-6 production GO:0032755 9.37 IL6 TLR9
7 negative regulation of interleukin-6 production GO:0032715 9.26 IL10 TLR9
8 positive regulation of chemokine production GO:0032722 9.16 IL6 TLR9
9 response to molecule of bacterial origin GO:0002237 8.96 IL10 TLR9
10 negative regulation of interleukin-8 production GO:0032717 8.62 IL10 TLR9
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Sources for Eye Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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