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MCID: EYL003
MIFTS: 30

Eye Lymphoma

Categories: Neuronal diseases, Cancer diseases, Eye diseases, Immune diseases
Genes Tissues Related diseases Pathways Drugs
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Aliases & Classifications for Eye Lymphoma

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MalaCards integrated aliases for Eye Lymphoma:

Name: Eye Lymphoma 12 15
Lymphoma of Eye 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Eye diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6903
NCIt 50 C35690
UMLS 73 C1333519
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Summaries for Eye Lymphoma

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Disease Ontology : 12 A lymphoma by site that is manifested in immune system cells called lymphocytes.

MalaCards based summary : Eye Lymphoma, also known as lymphoma of eye, is related to mucocutaneous leishmaniasis and coccidiosis. An important gene associated with Eye Lymphoma is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Th1 Differentiation Pathway and Tuberculosis. The drugs Doxorubicin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye.

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Related Diseases for Eye Lymphoma

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Diseases in the Lymphoma family:

Adult Lymphoma Eye Lymphoma

Diseases related to Eye Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 mucocutaneous leishmaniasis 10.5 IL10 TLR9
2 coccidiosis 10.5 IL10 TLR9
3 genital herpes 10.5 IL10 TLR9
4 nasal cavity disease 10.5 IL10 TLR9
5 opportunistic mycosis 10.5 IL10 TLR9
6 nose disease 10.5 IL10 TLR9
7 parasitic helminthiasis infectious disease 10.4 IL10 TLR9
8 upper respiratory tract disease 10.4 IL10 TLR9
9 intraocular lymphoma 10.4 C19orf48 IL10
10 cutaneous leishmaniasis 10.4 IL10 TLR9
11 irritable bowel syndrome 10.4 IL10 TLR9
12 aspergillosis 10.4 IL10 TLR9
13 bronchial disease 10.4 IL10 TLR9
14 plasmodium falciparum malaria 10.3 IL10 TLR9
15 allergic hypersensitivity disease 10.2 IL10 TLR9
16 viral pneumonia 10.1 IL6 TLR9
17 central nervous system vasculitis 10.1 IL6 TLR9
18 post-thrombotic syndrome 10.1 IL6 TLR9
19 perinatal necrotizing enterocolitis 10.1 IL6 TLR9
20 exanthem 10.1 IL6 TLR9
21 meningoencephalitis 10.1 IL6 TLR9
22 pulmonary tuberculosis 10.0 IL10 TLR9
23 uterine anomalies 10.0 IL6 TLR9
24 acute transverse myelitis 10.0 IL10 IL6
25 funisitis 10.0 IL10 IL6
26 multicentric castleman disease 10.0 IL10 IL6
27 listeriosis 10.0 IL10 IL6
28 transverse myelitis 10.0 IL10 IL6
29 hand, foot and mouth disease 10.0 IL10 IL6
30 intermediate uveitis 10.0 IL10 IL6
31 post-transplant lymphoproliferative disease 10.0 IL10 IL6
32 radiculopathy 10.0 IL10 IL6
33 eales disease 10.0 IL10 IL6
34 hemorrhagic fever 10.0 IL10 IL6
35 traumatic brain injury 10.0 IL10 IL6
36 hematopoietic stem cell transplantation 10.0 IL10 IL6
37 cytomegalovirus infection 10.0 IL10 IL6
38 placenta disease 10.0 IL6 TLR9
39 plasmodium vivax malaria 10.0 IL10 IL6
40 acute pyelonephritis 10.0 IL10 IL6
41 aphthous stomatitis 10.0 IL10 IL6
42 hemorrhagic fever with renal syndrome 10.0 IL10 IL6
43 viral encephalitis 10.0 IL10 IL6
44 complex regional pain syndrome 10.0 IL10 IL6
45 tonsillitis 10.0 IL6 TLR9
46 idiopathic neutropenia 10.0 IL10 IL6
47 rheumatic heart disease 10.0 IL10 IL6
48 prostatitis 10.0 IL10 IL6
49 brain injury 10.0 IL10 IL6
50 paracoccidioidomycosis 10.0 IL10 IL6

Graphical network of the top 20 diseases related to Eye Lymphoma:



Diseases related to Eye Lymphoma
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Symptoms & Phenotypes for Eye Lymphoma

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Drugs & Therapeutics for Eye Lymphoma

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Drugs for Eye Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
3
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
5
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7
Doxil Approved June 1999 Phase 2 31703
8 Dexamethasone acetate Phase 2 1177-87-3
9 glucocorticoids Phase 2
10
protease inhibitors Phase 2
11 Folic Acid Antagonists Phase 2
12 Gastrointestinal Agents Phase 2
13 HIV Protease Inhibitors Phase 2
14 Topoisomerase Inhibitors Phase 2
15 Hormone Antagonists Phase 2
16 Dermatologic Agents Phase 2
17 Nucleic Acid Synthesis Inhibitors Phase 2
18 Hormones Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 Peripheral Nervous System Agents Phase 2
21 Anti-Bacterial Agents Phase 2
22 Vitamin B Complex Phase 2
23 Antibiotics, Antitubercular Phase 2
24 Immunosuppressive Agents Phase 2
25 Anti-Infective Agents Phase 2
26 Antiemetics Phase 2
27 Anti-Inflammatory Agents Phase 2
28 Antirheumatic Agents Phase 2
29 BB 1101 Phase 2
30 Antimetabolites Phase 2
31 Antiviral Agents Phase 2
32 Autonomic Agents Phase 2
33 Antimetabolites, Antineoplastic Phase 2
34 Antineoplastic Agents, Hormonal Phase 2
35 Folate Nutraceutical Phase 2
36 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / o Terminated NCT01848652 Phase 2 infusion of MYOCET

Search NIH Clinical Center for Eye Lymphoma

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Genetic Tests for Eye Lymphoma

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Anatomical Context for Eye Lymphoma

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MalaCards organs/tissues related to Eye Lymphoma:

41
Eye
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Publications for Eye Lymphoma

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Variations for Eye Lymphoma

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Expression for Eye Lymphoma

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Search GEO for disease gene expression data for Eye Lymphoma.
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Pathways for Eye Lymphoma

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Pathways related to Eye Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Th1 Differentiation Pathway 65
Show member pathways
 11.82 IL10 IL6 TLR9
2
Tuberculosis 37
11.75 IL10 IL6 TLR9
3
C-type lectin receptor signaling pathway 37
Show member pathways
 11.67 IL10 IL6 TLR9
4
Pertussis 37
11.36 IL10 IL6
5
Dendritic Cells Developmental Lineage Pathway 65
11.2 IL10 IL6 TLR9
6
Interleukin-10 signaling 66
11.15 IL10 IL6
7
IL-10 Pathway 64
10.98 IL10 IL6
8
Cytokines and Inflammatory Response 1
10.88 IL10 IL6
9
Malaria 37
10.82 IL10 IL6 TLR9
10
African trypanosomiasis 37
10.34 IL10 IL6 TLR9
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GO Terms for Eye Lymphoma

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Biological processes related to Eye Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.58 IL10 IL6 PTPRK
2 inflammatory response GO:0006954 9.54 IL10 IL6 TLR9
3 defense response to Gram-negative bacterium GO:0050829 9.48 IL6 TLR9
4 positive regulation of B cell activation GO:0050871 9.46 IL6 TLR9
5 response to glucocorticoid GO:0051384 9.43 IL10 IL6
6 positive regulation of interleukin-6 production GO:0032755 9.32 IL6 TLR9
7 negative regulation of interleukin-6 production GO:0032715 9.26 IL10 TLR9
8 positive regulation of chemokine production GO:0032722 9.16 IL6 TLR9
9 response to molecule of bacterial origin GO:0002237 8.96 IL10 TLR9
10 negative regulation of interleukin-8 production GO:0032717 8.62 IL10 TLR9
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Sources for Eye Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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