MCID: EYL002
MIFTS: 33

Eyelid Carcinoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Eyelid Carcinoma

MalaCards integrated aliases for Eyelid Carcinoma:

Name: Eyelid Carcinoma 12 15
Carcinoma of the Eyelid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6425
NCIt 51 C6078
UMLS 74 C0920196

Summaries for Eyelid Carcinoma

MalaCards based summary : Eyelid Carcinoma, also known as carcinoma of the eyelid, is related to sweat gland cancer and papilloma. An important gene associated with Eyelid Carcinoma is FEZF2 (FEZ Family Zinc Finger 2). The drugs Radiopharmaceuticals and Technetium Tc 99m Sulfur Colloid have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and eye, and related phenotype is cellular.

Related Diseases for Eyelid Carcinoma

Diseases related to Eyelid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 sweat gland cancer 30.3 KRT20 KRT7
2 papilloma 29.9 KRT20 KRT7
3 adenoid squamous cell carcinoma 29.7 KRT20 KRT7
4 mucinous adenocarcinoma 29.7 KRT20 KRT7
5 meibomian cyst 29.7 KRT20 KRT7
6 lymphoepithelioma-like carcinoma 29.7 KRT20 KRT7
7 merkel cell carcinoma 29.4 KRT20 KRT7
8 sebaceous adenocarcinoma 10.6
9 basal cell carcinoma 1 10.6
10 basal cell carcinoma 10.6
11 squamous cell carcinoma 10.4
12 breast metaplastic carcinoma 10.2 FEZF1 FEZF2
13 lymph node tuberculosis 10.2 FEZF1 FEZF2
14 acute laryngitis 10.2 FEZF1 FEZF2
15 uterine inversion 10.2 FEZF1 FEZF2
16 phaeohyphomycosis 10.2 FEZF1 FEZF2
17 neurodermatitis 10.2 FEZF1 FEZF2
18 anus adenocarcinoma 10.1 KRT7 MFGE8
19 hidrocystoma 10.1 KRT7 MFGE8
20 apocrine sweat gland neoplasm 10.1 KRT7 MFGE8
21 cystic basal cell carcinoma 10.1 KRT20 KRT7
22 seminal vesicle adenocarcinoma 10.1 KRT20 KRT7
23 transverse colon cancer 10.1 KRT20 KRT7
24 appendix adenocarcinoma 10.1 KRT20 KRT7
25 malignant syringoma 10.1 KRT20 KRT7
26 glandular cystitis 10.1 KRT20 KRT7
27 papillary transitional carcinoma 10.1 KRT20 KRT7
28 krukenberg carcinoma 10.1 KRT20 KRT7
29 large intestine adenocarcinoma 10.1 KRT20 KRT7
30 linitis plastica 10.1 KRT20 KRT7
31 lung acinar adenocarcinoma 10.1 KRT20 KRT7
32 small cell carcinoma of the bladder 10.1 KRT20 KRT7
33 small cell carcinoma 10.1 KRT20 KRT7
34 intratubular embryonal carcinoma 10.1 KRT20 KRT7
35 vulval paget's disease 10.1 KRT20 KRT7
36 bile duct cystadenocarcinoma 10.1 KRT20 KRT7
37 bile duct adenoma 10.1 KRT20 KRT7
38 jejunal adenocarcinoma 10.1 KRT20 KRT7
39 ovarian mucinous adenocarcinoma 10.1 KRT20 KRT7
40 thymus adenocarcinoma 10.1 KRT20 KRT7
41 appendix disease 10.1 KRT20 KRT7
42 gastric diffuse adenocarcinoma 10.1 KRT20 KRT7
43 bladder lymphoma 10.1 KRT20 KRT7
44 papillary serous adenocarcinoma 10.1 KRT20 KRT7
45 muir-torre syndrome 10.1
46 bladder adenocarcinoma 10.1 KRT20 KRT7
47 chronic cystitis 10.1 KRT20 KRT7
48 vulva adenocarcinoma 10.1 KRT20 KRT7
49 medulloepithelioma 10.1 KRT20 KRT7
50 glycogen-rich clear cell breast carcinoma 10.1 KRT20 KRT7

Graphical network of the top 20 diseases related to Eyelid Carcinoma:



Diseases related to Eyelid Carcinoma

Symptoms & Phenotypes for Eyelid Carcinoma

MGI Mouse Phenotypes related to Eyelid Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.02 BAG3 FEZF1 FEZF2 KRT7 MFGE8

Drugs & Therapeutics for Eyelid Carcinoma

Drugs for Eyelid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Radiopharmaceuticals Phase 2
2 Technetium Tc 99m Sulfur Colloid Phase 2
3 Anesthetics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Periocular Basal Cell Carcinoma (BCC): Permanent vs. Frozen Section Pathological Control Unknown status NCT00663650 Phase 3
2 Sentinel Lymph Node (SLN) Biopsy for Sebaceous Gland Carcinoma of Eyelid Recruiting NCT00832429 Phase 2 Tc99m-Sulfur colloid
3 Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma Active, not recruiting NCT00386906 Phase 1

Search NIH Clinical Center for Eyelid Carcinoma

Genetic Tests for Eyelid Carcinoma

Anatomical Context for Eyelid Carcinoma

MalaCards organs/tissues related to Eyelid Carcinoma:

42
Lymph Node, Skin, Eye, Colon

Publications for Eyelid Carcinoma

Articles related to Eyelid Carcinoma:

(show top 50) (show all 202)
# Title Authors Year
1
Change in Eyelid Carcinoma T Category With Use of the 8th Versus 7th Edition of the American Joint Committee on Cancer: Cancer Staging Manual. ( 29877957 )
2019
2
Merkel Cell Carcinoma of the Eyelid: a Review. ( 30871952 )
2019
3
Treatment of squamous cell carcinoma of the eyelid with imiquimod 5% cream. ( 30851791 )
2019
4
Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling. ( 30405815 )
2018
5
Gamma knife radiosurgery for basal cell carcinoma of the eyelid: report of a case. ( 29080088 )
2018
6
Merkel cell carcinoma of the eyelid and orbit. ( 30541295 )
2018
7
A case series of Merkel cell carcinoma of the eyelid: a rare entity often misdiagnosed. ( 30373432 )
2018
8
Endocrine mucin-producing sweat gland carcinoma of the eyelid: A clinical and histological conundrum. ( 29941769 )
2018
9
Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. ( 30131380 )
2018
10
Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis. ( 30373440 )
2018
11
Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid. ( 30027448 )
2018
12
Treatment of Metastatic Eyelid Carcinoma. ( 28885435 )
2017
13
Case series: Merkel cell carcinoma of the eyelid. ( 28985829 )
2017
14
Demonstration of a Borst-Jadassohn-Like Phenomenon in Sebaceous Carcinoma of the Eyelid. ( 26020718 )
2017
15
Bilateral Primary Mucinous Carcinoma of the Eyelid. ( 26950474 )
2017
16
Primary signet-ring cell/histiocytoid carcinoma of the eyelid expressing androgen receptors and treated with bicalutamide. ( 28543368 )
2017
17
Primary Cutaneous Mucinous Carcinoma of the Eyelid. ( 29043010 )
2017
18
Primary mucinous carcinoma of the eyelid treated with Mohs micrographic surgery. ( 29232431 )
2017
19
Giant basal cell carcinoma of the eyelid: a case history. ( 28154636 )
2016
20
Clinicopathological analysis of recurrent basal cell carcinoma of the eyelid. ( 26985178 )
2016
21
Merkel cell carcinoma of the eyelid. A series of 5 cases and review of the literature. ( 26723858 )
2016
22
Merkel Cell Carcinoma of the Eyelid. ( 26979008 )
2016
23
Recurrent Squamous Cell Carcinoma of the Eyelid Presenting as Trigeminal Neuralgia. ( 28097083 )
2016
24
Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid: A Report of a Case With Molecular Analysis. ( 26675355 )
2016
25
Histopathology of endocrine mucin-producing sweat gland carcinoma of the eyelid. ( 27085285 )
2016
26
Recurrent sebaceous carcinoma of the eyelid: Outcome after postoperative reirradiation. ( 25900883 )
2016
27
Sebaceous Carcinoma of the Eyelid. ( 27218789 )
2016
28
Reply to Letter to the Editor regarding recurrent sebaceous carcinoma of the eyelid: Outcome after postoperative reirradiation. ( 27473551 )
2016
29
Letter to the Editor regarding recurrent sebaceous carcinoma of the eyelid: Outcome after postoperative reirradiation. ( 27473673 )
2016
30
Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid: A "Binocle" Presentation of the "Monocle Tumor". ( 27391452 )
2016
31
Primary Cutaneous Mucinous Carcinoma of the Eyelid. ( 28913279 )
2016
32
Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review. ( 26466235 )
2015
33
Primary Merkel Cell Carcinoma of the Eyelid-- Clinical, Histopathological, Immunohistochemical and Electron Microscopical Features: A Case Report. ( 26259404 )
2015
34
Cutaneous squamous cell carcinoma of the eyelid masquerading as a chalazion. ( 25479697 )
2015
35
Sebaceous gland carcinoma of the eyelid: clinicopathological features and outcome in Asian Indians. ( 25998946 )
2015
36
Primary cutaneous mucinous carcinoma of the eyelid treated with Mohs surgery. ( 27051692 )
2015
37
Interstitial brachytherapy for eyelid carcinoma : Outcome analysis in 60 patients. ( 24424628 )
2014
38
Correlation of American Joint Committee on Cancer T category for eyelid carcinoma with outcomes in patients with periocular Merkel cell carcinoma. ( 24841735 )
2014
39
Merkel cell carcinoma of the eyelid and periocular region. ( 24821131 )
2014
40
Sentinel node biopsy and frozen section procedure in signet ring cell carcinoma of the eyelid and orbit. ( 23910914 )
2014
41
Impact of AJCC 'T' designation on risk of regional lymph node metastasis in patients with squamous carcinoma of the eyelid. ( 24429279 )
2014
42
Mucinous carcinoma of the eyelid with colonic mass: a rare partnership. ( 24676812 )
2014
43
Mucinous eccrine carcinoma of the eyelid: re-emphasizing the need for awareness of rare lesions. ( 25386330 )
2014
44
Combined excision and intralesional bevacizumab for sebaceous carcinoma of the eyelid in an Amur tiger (Panthera tigris altaica). ( 22857265 )
2013
45
Sebaceous carcinoma of the eyelid: anatomoclinical data. ( 24068422 )
2013
46
Signet-ring cell/histiocytoid carcinoma of the eyelid: a case report and review of the literature. ( 22885554 )
2013
47
Results of radical radiotherapy for squamous cell carcinoma of the eyelid. ( 23750022 )
2013
48
Primary signet ring cell carcinoma of the eyelid. ( 24063437 )
2013
49
Pleomorphic basal cell carcinoma of the eyelid with true ductular differentiation. ( 22037988 )
2012
50
Noninvasive and curative radiation therapy for sebaceous carcinoma of the eyelid. ( 21300468 )
2012

Variations for Eyelid Carcinoma

Expression for Eyelid Carcinoma

Search GEO for disease gene expression data for Eyelid Carcinoma.

Pathways for Eyelid Carcinoma

GO Terms for Eyelid Carcinoma

Biological processes related to Eyelid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.4 KRT20 KRT7
2 positive regulation of neuron differentiation GO:0045666 9.37 FEZF1 FEZF2
3 forebrain development GO:0030900 9.32 FEZF1 FEZF2
4 regulation of neurogenesis GO:0050767 9.26 FEZF1 FEZF2
5 telencephalon development GO:0021537 9.16 FEZF1 FEZF2
6 cell dedifferentiation GO:0043697 8.96 FEZF1 FEZF2
7 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF1 FEZF2

Sources for Eyelid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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