MCID: EYL005
MIFTS: 40

Eyelid Disease

Categories: Eye diseases, Skin diseases

Aliases & Classifications for Eyelid Disease

MalaCards integrated aliases for Eyelid Disease:

Name: Eyelid Disease 12 15 17
Eyelid Diseases 44 70
Abnormality of the Eyelid 29
Eyelid Disorders 42

Classifications:



External Ids:

Disease Ontology 12 DOID:530
ICD9CM 34 374.9
MeSH 44 D005141
NCIt 50 C26768
SNOMED-CT 67 60113004
UMLS 70 C0015423

Summaries for Eyelid Disease

MedlinePlus : 42 Your eyelids help protect your eyes. When you blink, your eyelids spread moisture over your eyes. Blinking also helps move dirt or other particles off the surface of the eye. You close your eyelids when you see something coming toward your eyes. This can help protect against injuries. Like most other parts of your body, your eyelids can get infected, inflamed, or even develop cancer. There are also specific eyelid problems, including Eyelids that turn in or out Eyelids that droop Abnormal blinking or twitching Treatment of eyelid problems depends on the cause.

MalaCards based summary : Eyelid Disease, also known as eyelid diseases, is related to blepharitis and familial isolated trichomegaly, and has symptoms including lid retraction or lag, eye manifestations and eyelid pain. An important gene associated with Eyelid Disease is FOXL2 (Forkhead Box L2), and among its related pathways/superpathways is Mitotic Telophase/Cytokinesis. The drugs Acetylcholine and Mineral oil have been mentioned in the context of this disorder. Affiliated tissues include eyelid, eye and brain, and related phenotypes are homeostasis/metabolism and integument

Disease Ontology : 12 An adnexa disease that is located in the eyelid.

Wikipedia : 73 An eyelid is a thin fold of skin that covers and protects an eye. The levator palpebrae superioris... more...

Related Diseases for Eyelid Disease

Diseases related to Eyelid Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 blepharitis 31.7 LACRT CD4 CCR6
2 familial isolated trichomegaly 31.7 SMC3 SMC1A NIPBL
3 dacryoadenitis 30.0 LACRT CD4 CCR6
4 ptosis 29.9 UBE3B PISRT1 KAT6B FOXL2
5 ectropion 29.5 TGM1 PNPLA1 NIPAL4 CYP4F22 CRYAA ALOXE3
6 hyperpigmentation of eyelids 10.9
7 blepharochalasis 10.9
8 marcus gunn phenomenon 10.4 UBE3B FOXL2
9 ainhum 10.4 PNPLA1 NIPAL4
10 abnormal hair, joint laxity, and developmental delay 10.4 NIPBL FOXL2
11 pylorospasm 10.4 UBE3B KAT6B
12 orbital cellulitis 10.3 CRYAA CD4
13 acute orbital inflammation 10.3 CRYAA CD4
14 suppurative lymphadenitis 10.3 CD4 CCR6
15 herpes simplex virus keratitis 10.3 CD4 CCR6
16 mikulicz disease 10.3 CD4 CCR6
17 chancroid 10.3 CD4 CCR6
18 erythrokeratodermia variabilis et progressiva 1 10.3 TGM1 NIPAL4 CRYAA ABCA12
19 autoimmune disease of eyes, ear, nose and throat 10.3 CRYAA CD4 CCR6
20 keratoconjunctivitis sicca 10.3 LACRT CD4 CCR6
21 corneal dystrophy, subepithelial mucinous 10.3 SMC1A CRYAA
22 cranial nerve disease 10.3 CRYAA CD4 CCR6
23 uveal disease 10.3 CRYAA CD4 CCR6
24 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
25 chanarin-dorfman syndrome 10.3 PNPLA1 CYP4F22 ALOXE3
26 ichthyosis, congenital, autosomal recessive 2 10.3 ALOXE3 ALOX12B
27 esophageal candidiasis 10.3 CD4 CCR6
28 cornelia de lange syndrome 3 with or without midline brain defects 10.3 SMC3 SMC1A NIPBL
29 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.3 NIPAL4 ALOXE3 ALOX12B ABCA12
30 cornelia de lange syndrome 4 with or without midline brain defects 10.3 SMC3 SMC1A NIPBL
31 keratitis, hereditary 10.3 CRYAA CD4 CCR6
32 chronic atrial and intestinal dysrhythmia 10.3 SMC3 SMC1A NIPBL
33 blepharophimosis 10.3 UBE3B PISRT1 KAT6B FOXL2
34 warsaw breakage syndrome 10.2 SMC3 SMC1A NIPBL
35 lacrimal apparatus disease 10.2 LACRT CRYAA CD4 CCR6
36 corneal disease 10.2 LACRT CRYAA CD4 CCR6
37 x-linked recessive disease 10.2 CRYAA CD4 CCR6
38 subcutaneous mycosis 10.2 CD4 CCR6
39 autoimmune disease of central nervous system 10.2 CRYAA CD4 CCR6
40 autoimmune disease of the nervous system 10.2 CRYAA CD4 CCR6
41 x-linked chondrodysplasia punctata 2 10.2 TGM1 CRYAA ALOXE3 ALOX12B ABCA12
42 roberts-sc phocomelia syndrome 10.2 SMC3 SMC1A NIPBL CRYAA
43 diaphragmatic hernia, congenital 10.2 SMC3 SMC1A NIPBL
44 kbg syndrome 10.2 SMC3 SMC1A NIPBL KAT6B
45 acrokeratosis verruciformis 10.2 TGM1 NIPAL4 CYP4F22 ALOX12B ABCA12
46 pneumonic tularemia 10.2 CD4 CCR6
47 epidermolytic hyperkeratosis 10.2 TGM1 PNPLA1 NIPAL4 ALOXE3 ABCA12
48 ichthyosis, congenital, autosomal recessive 4a 10.2 TGM1 ABCA12
49 blastomycosis 10.1 CD4 CCR6
50 x-linked monogenic disease 10.1 CRYAA CD4 CCR6

Graphical network of the top 20 diseases related to Eyelid Disease:



Diseases related to Eyelid Disease

Symptoms & Phenotypes for Eyelid Disease

UMLS symptoms related to Eyelid Disease:


lid retraction or lag; eye manifestations; eyelid pain

MGI Mouse Phenotypes related to Eyelid Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ABCA12 ALOX12B ALOXE3 CCR6 CD4 CYP4F22
2 integument MP:0010771 9.61 ABCA12 ALOX12B ALOXE3 CD4 CYP4F22 NIPAL4
3 mortality/aging MP:0010768 9.44 ABCA12 ALOX12B ALOXE3 CD4 CYP4F22 FOXL2

Drugs & Therapeutics for Eyelid Disease

Drugs for Eyelid Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
3
Petrolatum Approved, Investigational Phase 4 8009-03-8
4
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
5
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
6 abobotulinumtoxinA Phase 4
7 Cholinergic Agents Phase 4
8 Botulinum Toxins, Type A Phase 4
9 Botulinum Toxins Phase 4
10 Anti-Bacterial Agents Phase 4
11 Antibiotics, Antitubercular Phase 4
12 Lubricant Eye Drops Phase 4
13 Gastrointestinal Agents Phase 4
14 Anti-Infective Agents, Local Phase 4
15 Erythromycin Ethylsuccinate Phase 4
16 Polymyxins Phase 4
17 Erythromycin stearate Phase 4
18 Erythromycin Estolate Phase 4
19 Anti-Infective Agents Phase 4
20
Fluorometholone Approved, Investigational Phase 3 426-13-1 9878
21 Hormones Phase 3
22 Pharmaceutical Solutions Phase 3
23 Ophthalmic Solutions Phase 3
24 Anti-Allergic Agents Phase 3
25 Hormone Antagonists Phase 3
26 glucocorticoids Phase 3
27 Anti-Inflammatory Agents Phase 3
28
Lidocaine Approved, Vet_approved 137-58-6 3676
29
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
30
Tetracaine Approved, Vet_approved 94-24-6 5411
31
Tamsulosin Approved, Investigational 106133-20-4 129211
32 Hemostatics
33 Neurotransmitter Agents
34 Anesthetics
35 Anesthetics, Local
36 Proxymetacaine
37 Adrenergic alpha-Antagonists
38 Adrenergic Antagonists
39 Adrenergic alpha-1 Receptor Antagonists
40 Adrenergic Agents

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Botulinum Toxin to Improve Lower Blepharoplasty Scar Unknown status NCT02786550 Phase 4 Botulinum Toxin
2 Phase IV Multicentric Study, 30 Patients Suffering of Meibomian Glands Dysfunction. Completed NCT01091311 Phase 4
3 Phase IV Multicentric Study, 140 Patients Suffering of Meibomian Glands Dysfunction. Completed NCT01189474 Phase 4
4 The Role of Topical Antibiotic Prophylaxis in Eyelid Surgery Completed NCT03199911 Phase 4 Topical Antibiotic Product;Topical Non-Antibiotic Ointment
5 FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial Not yet recruiting NCT04149210 Phase 3 Fluorometholone 0.1% Oph Susp;Artificial Tears
6 Clinical Safety Study on an Eyelid Warming Device, Moist Heat Technology BLEPHASTEAM®, to Evaluate the Eyelid and Cornea Temperature in Healthy Volunteers Completed NCT01086943 Phase 1
7 Phase I, Prospective, Comparative Study, Investigator Masked , Monocentric Measuring Warming Efficiency and Safety of Blephasteam® Versus Warm Compresses in Eyelid Therapy Completed NCT01190397 Phase 1
8 Efficacy of Bandage Contact Lenses Versus Eye Patching in Early Postoperative Period of Müller's Muscle-conjunctival Resection Completed NCT04554329
9 Management of Eyelid Disorders by Ophthalmologists in Usual Medical Practice Completed NCT01552174
10 Objective and Subjective Functional Outcomes Following Upper Blepharoplasty Recruiting NCT04201925
11 Outcome of Eyelid Crush for Intraoperative Hemostasis of Eyelid Margin Surgery Recruiting NCT04255667
12 Comparison of the Efficacy Between Small Incision Technique and Upper Blepharoplasty in Treatment of Upper Eyelid Medial Pad Fat Bulge Recruiting NCT04689230
13 Lower Eyelid Retractors Plication , Transcutaneous Blepharoplasty and Wedge Resection for Treatment of Lower Eyelid Involutional Entropion and Dermatochalasis Recruiting NCT04720586
14 Long Term Efficacy of Different Approaches in the Treatment of Tear Trough Deformity Recruiting NCT04538716
15 Comparative Study of Transconjunctival vs. Transcutaneous Routes for Administration of Local Anaesthesia in Oculoplastic Surgery Recruiting NCT04102878 Topical Anesthetic
16 Treatment With Tamsulosin for Upper Eyelid Retraction Related to Thyroid Eye Disease. Recruiting NCT04359979 Tamsulosin
17 Telemedicine Follow-up for Routine, Low-Risk Oculoplastic Surgery Not yet recruiting NCT04235803
18 Study Protocol for Comparison of Lower Eyelid Retraction Repair With Hard Palate, Autologous Ear Cartilage, and Porcine Acellular Dermal Matrix Spacer Grafts Suspended NCT04140734

Search NIH Clinical Center for Eyelid Disease

Cochrane evidence based reviews: eyelid diseases

Genetic Tests for Eyelid Disease

Genetic tests related to Eyelid Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Eyelid 29

Anatomical Context for Eyelid Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Eyelid Disease:

19
Eyelid

MalaCards organs/tissues related to Eyelid Disease:

40
Eye, Brain, Thyroid, Skin

Publications for Eyelid Disease

Articles related to Eyelid Disease:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Palpebral anthrax, a rare though important condition in villagers: A case report and literature review. 42
32758692 2020
2
Analysis of corneal real astigmatism and high order aberration changes that cause visual disturbances after lower eyelid epiblepharon repair surgery. 42
32366891 2020
3
A Comparison of Lower Eyelid Retraction in Normal Individuals with Positive versus Negative Orbital Vector. 42
32549720 2020
4
Injectable bio-responsive hydrogel for therapy of inflammation related eyelid diseases. 61
33778188 2021
5
The upper eyelid levator weakening procedure for the correction of severe cicatricial entropion caused by trachoma. 61
33302671 2020
6
[Corneal alterations in eyelid diseases]. 61
32870336 2020
7
The good toxin: 10 years of experience with botulinum toxin A in the treatment of benign essential blepharospasm. 61
32544987 2020
8
Ocular involvement in epidermolysis bullosa acquisita with long-term follow-up. 61
31088794 2020
9
Impact of Canthal Height on Horizontal Upper Eyelid Peak Position: A Guide for Blepharoptosis Surgery. 61
31764562 2020
10
Normograde nasolacrimal placement of an ocular-lavage system for treatment of equine eye diseases. 61
31281192 2019
11
Comparative study between conventional camera images and smartphone images for eyelid tumor telediagnosis. 61
30843945 2019
12
Giant Dermatofibrosarcoma Protuberans With Bilateral Orbital Involvement. 61
30730435 2019
13
Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease. 61
29950407 2018
14
Synchronous Surgical Treatment of Lower Eyelid Involutional Entropion and Ptosis. 61
30534454 2018
15
Molecularly targeted agents in oculoplastic surgery. 61
28598870 2017
16
Use of Crossed Polarizers to Enhance Images of the Eyelids. 61
28257379 2017
17
Effects of chalazia on corneal astigmatism : Large-sized chalazia in middle upper eyelids compress the cornea and induce the corneal astigmatism. 61
28359272 2017
18
ORBITAL AND ADNEXAL LYMPHOMAS AMONG ADULT PATIENTS IN GHANA. 61
29181369 2016
19
Clinical features of intratarsal keratinous cysts. 61
26427989 2016
20
En bloc resection of lacrimal sac tumors and simultaneous orbital reconstruction: surgical and functional outcomes. 61
24814277 2014
21
Long-term tear volume changes after blepharoptosis surgery and blepharoplasty. 61
25425312 2014
22
Orbito-oculoplastic diseases in lagos: a 4-year prospective study. 61
25100908 2014
23
Merkel cell carcinoma of the eyelid: management and prognosis. 61
24287584 2014
24
Short-term changes in tear volume after blepharoptosis repair. 61
24212766 2014
25
Ectropion and entropion in sub-Saharan Africa: how do we differ? 61
24309406 2013
26
Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %). 61
22527308 2012
27
Prevalence of signs and symptoms of ocular surface disease in individuals treated and not treated with glaucoma medication. 61
22394358 2012
28
Ambient levels of air pollution induce clinical worsening of blepharitis. 61
22204918 2012
29
Efficacy of azithromycin 1% ophthalmic solution for treatment of ocular surface disease from posterior blepharitis. 61
21083761 2011
30
Double motion of upper eyelids in Graves' orbitopathy: an additional sign for detection of thyroid dysfunction or positive thyroid autoantibodies. 61
21468341 2011
31
Utility of meibography in the evaluation of meibomian glands morphology in normal and diseased eyelids. 61
23960903 2011
32
Metastasis to eyelid as initial presentation of non-small cell carcinoma. 61
19966662 2009
33
[4/6. Eyelid diseases]. 61
19637465 2009
34
Dry eye and blepharitis: approaching the patient with chronic eye irritation. 61
19572764 2009
35
Metastatic eyelid disease associated with primary breast carcinoma: case report. 61
19668974 2009
36
Microbial keratitis in patients with down syndrome: a retrospective study. 61
19158558 2009
37
Metastatic eyelid disease associated with hepatocellular carcinoma. 61
17724490 2007
38
Blinking patterns and corneal staining. 61
17099390 2006
39
[Sebaceous carcinoma of the eyelids--case reports and review of the literature]. 61
16986089 2006
40
Eyelid disease. 61
16271321 2005
41
Remodelling the upper eyelid in the management of orbitopalpebral neurofibromatosis. 61
16043142 2005
42
Treatment of atopic eyelid disease using topical tacrolimus following corticosteroid discontinuation in a patient with open-angle glaucoma. 61
15502487 2004
43
Advances in applied anatomy of the eyelid and orbit. 61
15625904 2004
44
Clinical features associated with survival of patients with lymphoma of the ocular adnexa. 61
14528242 2003
45
Topical tacrolimus treatment of atopic eyelid disease. 61
12614745 2003
46
Dry eye syndrome. Etiological and therapeutic aspects. 61
15083682 2003
47
Lower eyelid medial canthal tendon laxity grading: an interobserver study of normal subjects. 61
11733279 2001
48
Ocular allergies. 61
11892063 2001
49
Gender influences herpes simplex virus type 1 infection in normal and gamma interferon-mutant mice. 61
11222734 2001
50
Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. 61
11115257 2000

Variations for Eyelid Disease

Expression for Eyelid Disease

Search GEO for disease gene expression data for Eyelid Disease.

Pathways for Eyelid Disease

Pathways related to Eyelid Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.21 SMC3 SMC1A NIPBL

GO Terms for Eyelid Disease

Cellular components related to Eyelid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cohesin complex GO:0008278 8.96 SMC3 SMC1A
2 meiotic cohesin complex GO:0030893 8.62 SMC3 SMC1A

Biological processes related to Eyelid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of calcium-mediated signaling GO:0050850 9.43 LACRT CD4
2 keratinocyte differentiation GO:0030216 9.43 TGM1 PNPLA1 ABCA12
3 lipoxygenase pathway GO:0019372 9.4 ALOXE3 ALOX12B
4 mitotic sister chromatid cohesion GO:0007064 9.37 SMC1A NIPBL
5 stem cell population maintenance GO:0019827 9.33 SMC3 SMC1A NIPBL
6 hepoxilin biosynthetic process GO:0051122 9.32 ALOXE3 ALOX12B
7 ceramide biosynthetic process GO:0046513 9.26 PNPLA1 CYP4F22 ALOXE3 ALOX12B
8 establishment of skin barrier GO:0061436 8.92 PNPLA1 ALOXE3 ALOX12B ABCA12

Molecular functions related to Eyelid Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 8.96 ALOXE3 ALOX12B
2 mediator complex binding GO:0036033 8.8 SMC3 SMC1A NIPBL

Sources for Eyelid Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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