Aliases & Classifications for Facial Dermatosis

MalaCards integrated aliases for Facial Dermatosis:

Name: Facial Dermatosis 12 15 17
Facial Dermatoses 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3134
MeSH 44 D005148
UMLS 70 C0015456

Summaries for Facial Dermatosis

MalaCards based summary : Facial Dermatosis, also known as facial dermatoses, is related to brachyolmia and spondyloepiphyseal dysplasia, maroteaux type, and has symptoms including pruritus and exanthema. An important gene associated with Facial Dermatosis is TRPV3 (Transient Receptor Potential Cation Channel Subfamily V Member 3), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Ion channel transport. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Decreased NANOG protein expression and Decreased NANOG protein expression

Related Diseases for Facial Dermatosis

Diseases related to Facial Dermatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 brachyolmia 10.2 TRPV4 TRPV3 TRPV2
2 spondyloepiphyseal dysplasia, maroteaux type 10.2 TRPV4 TRPA1
3 metatropic dysplasia 10.2 TRPV4 TRPV3
4 parastremmatic dwarfism 10.2 TRPV4 TRPA1
5 photokeratitis 10.2 TRPV1 TRPA1
6 photoparoxysmal response 1 10.2 TRPV4 TRPV3
7 skin disease 10.1
8 scapuloperoneal spinal muscular atrophy 10.1 TRPV4 TRPV3 TRPV2 TRPA1
9 netherton syndrome 10.1 KLK5 KLK4 CTRL
10 erythromelalgia 10.1 TRPV3 TRPV1 TRPA1
11 folliculitis 10.1
12 diabetic neuropathy 10.1 TRPV4 TRPV3 TRPV1
13 acne 10.1
14 rosacea 10.1
15 paroxysmal extreme pain disorder 10.0 TRPV4 TRPV1 TRPA1
16 dentin sensitivity 10.0 TRPV3 TRPV2 TRPV1 TRPA1
17 contact dermatitis 10.0
18 seborrheic dermatitis 10.0
19 neurogenic bowel 10.0 VIP TAC1
20 anismus 9.9 VIP TAC1
21 inflammatory bowel disease 28 9.9 TRPV2 TRPV1
22 endometrial small cell carcinoma 9.9 VIP TAC1
23 acute apical periodontitis 9.9 TAC1 CTRL
24 paralytic ileus 9.9 VIP TAC1
25 appendix lymphoma 9.9 TAC1 KLK4
26 intracranial vasospasm 9.9 VIP TAC1
27 akinetopsia 9.9 TAC1 KLK4
28 myofascial pain syndrome 9.9 TRPV1 TAC1
29 causalgia 9.9 TRPV1 TAC1
30 mutilating palmoplantar keratoderma with periorificial keratotic plaques 9.9 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
31 tendinosis 9.9 TGFB2 MMP1
32 detrusor sphincter dyssynergia 9.9 TRPV1 TAC1
33 dermatitis, atopic 9.8
34 anxiety 9.8
35 covid-19 9.8
36 panniculitis 9.8
37 allergic contact dermatitis 9.8
38 secondary syphilis 9.8
39 syphilis 9.8
40 spongiotic dermatitis 9.8
41 depression 9.8
42 reflex sympathetic dystrophy 9.8 TRPV1 TAC1
43 dowling-degos disease 1 9.8
44 exanthem 9.8
45 telangiectasis 9.8
46 calcinosis 9.8
47 dermatitis 9.8
48 hypertrichosis 9.8
49 pyoderma 9.8
50 lichen nitidus 9.8

Graphical network of the top 20 diseases related to Facial Dermatosis:



Diseases related to Facial Dermatosis

Symptoms & Phenotypes for Facial Dermatosis

UMLS symptoms related to Facial Dermatosis:


pruritus; exanthema

GenomeRNAi Phenotypes related to Facial Dermatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased NANOG protein expression GR00184-A-3 9.17 TRPA1
2 Decreased NANOG protein expression GR00184-A-6 9.17 CAMP KLK5 TRPA1
3 Decreased NANOG protein expression GR00184-A-8 9.17 CAMP KLK5 TRPA1

MGI Mouse Phenotypes related to Facial Dermatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 ANK1 DPYD KLK5 MYD88 NR1H4 TAC1
2 immune system MP:0005387 9.4 ANK1 CAMP DPYD MMP1 MYD88 NR1H4

Drugs & Therapeutics for Facial Dermatosis

Drugs for Facial Dermatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Racepinephrine Approved 329-65-7 838
3
Lidocaine Approved, Vet_approved 137-58-6 3676
4 Anesthetics
5 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of a 585 nm Pulsed Dye Laser (PDL) for the Treatment of Dermatosis Papulosa Nigra, and Compare it to Therapy With Curettage and Electrodesiccation. Completed NCT00710203

Search NIH Clinical Center for Facial Dermatosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Alclometasone
alclometasone dipropionate
amcinonide
Betamethasone
Betamethasone acetate
Betamethasone benzoate
betamethasone dipropionate
betamethasone sodium phosphate
Betamethasone valerate
BETAMETHASONE VALERATE PWDR
Clobetasol
Clobetasol Propionate
clocortolone
clocortolone pivalate
Desonide
Desoximetasone
Diflorasone
diflorasone diacetate
fluocinolone
Fluocinolone Acetonide
Flurandrenolide
Halcinonide
halobetasol
halobetasol propionate
Hydrocortisone
hydrocortisone acetate
HYDROCORTISONE ACETATE PWDR
HYDROCORTISONE ACETONIDE
Hydrocortisone butyrate
hydrocortisone cypionate
hydrocortisone probutate
HYDROCORTISONE PWDR
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
hydrocortisone valerate
HYDROCORTISONE,NONSTERILE PWDR
Lactic acid
LACTIC ACID LIQUID
LACTIC ACID,BUFFERED
prednicarbate
Tretinoin
TRETINOIN PWDR
Triamcinolone
Triamcinolone Acetonide
TRIAMCINOLONE ACETONIDE PWDR
triamcinolone diacetate
triamcinolone hexacetonide

Cochrane evidence based reviews: facial dermatoses

Genetic Tests for Facial Dermatosis

Anatomical Context for Facial Dermatosis

MalaCards organs/tissues related to Facial Dermatosis:

40
Skin

Publications for Facial Dermatosis

Articles related to Facial Dermatosis:

(show top 50) (show all 112)
# Title Authors PMID Year
1
Mask-induced Koebner phenomenon and its clinical phenotypes: A multicenter, real-life study focusing on 873 dermatological consultations during COVID-19 pandemics. 61
33527560 2021
2
Dermatological findings in patients admitting to dermatology clinic after using face masks during Covid-19 pandemia: A new health problem. 61
33751746 2021
3
Facial dermatoses in the general population due to wearing of personal protective masks during the COVID-19 pandemic: first observations after lockdown. 61
32658350 2021
4
COVID-19 related masks increase severity of both acne (maskne) and rosacea (mask rosacea): Multi-center, real-life, telemedical, and observational prospective study. 61
33533563 2021
5
Investigating the factors enabling the accurate implementation of the patient-assisted teledermatology model during the pandemic in Turkey: A pilot study. 61
33404147 2021
6
89% Vichy mineralizing water with hyaluronic acid is a well-tolerated adjunct treatment that helps restore skin barrier function in dry skin-related inflammatory dermatoses and post-procedure skin care: A Canadian study. 61
33786979 2021
7
Increased Prevalence of Face Mask-Induced Itch in Health Care Workers. 61
33297438 2020
8
The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea? 61
33095403 2020
9
Jogger's facial dermatoses: An emerging entity in COVID-19 pandemic. 61
32909646 2020
10
Clinical and noninvasive instrumental evaluation of the efficacy of a nonsteroidal anti-inflammatory 8-beta glycyrrhetinic acid cream for the treatment of erythema in rosacea. 61
32833275 2020
11
Analysis of facial redness by comparing VISIA® from Canfield and CSKIN® from Yanyun Technology. 61
32196761 2020
12
Flare-up of Rosacea due to Face Mask in Healthcare Workers During COVID-19. 61
33312262 2020
13
Personal protective equipment induced facial dermatoses in healthcare workers managing Coronavirus disease 2019. 61
32396675 2020
14
Face Mask-induced Itch: A Self-questionnaire Study of 2,315 Responders During the COVID-19 Pandemic. 61
32449781 2020
15
Study of Clinical Profile of Patients Presenting with Topical Steroid-Induced Facial Dermatosis to a Tertiary Care Hospital. 61
32477980 2020
16
Vichy mineralizing water with hyaluronic acid is effective and well tolerated as an adjunct to the management of various dermatoses and after esthetic procedures. 61
31793738 2020
17
Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis. 61
32113677 2020
18
Impact of Abuse of Topical Corticosteroids and Counterfeit Cosmetic Products for the Face: Prospective Demographic Study in Basrah City, Iraq. 61
31573892 2020
19
Anxiety, Depression, and Suicidal Ideation amongst Patients with Facial Dermatoses (Acne, Rosacea, Perioral Dermatitis, and Folliculitis) in Lithuania. 61
32252051 2020
20
Postinflammatory Hyperpigmentation following Electrodesiccation with a Eutectic Mixture of Local Anesthetics. 61
33032686 2020
21
Lichenoid pseudovesicular papular eruption on nose: A papular facial dermatosis probably related to actinic lichen nitidus or micropapular polymorphous light eruption. 61
31293275 2019
22
Erythematotelangiectatic rosacea may be associated with a subclinical stage of demodicosis: a case-control study. 61
30801673 2019
23
A case series of demodicosis in children. 61
31197860 2019
24
The Role of the Skin Barrier in Periorificial Dermatitis. 61
31542061 2019
25
Dermoscopy of Inflammatory Dermatoses (Inflammoscopy): An Up-to-Date Overview. 61
31384489 2019
26
Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments. 61
30585305 2019
27
The Use of Oral Antibiotics in the Management of Rosacea 61
31251542 2019
28
New indications for topical ivermectin 1% cream: a case series study. 61
30858780 2019
29
[Facial dermatosis in practice]. 61
30869467 2018
30
Topical Steroid Damaged/Dependent Face (TSDF): A Study from a Tertiary Care Hospital in Eastern India. 61
30210157 2018
31
Topical Application of 5-Fluorouracil Associated with Distant Seborrheic Dermatitis-like Eruption: Case Report and Review of Seborrheic Dermatitis Cutaneous Reactions after Systemic or Topical Treatment with 5-Fluorouracil. 61
30051297 2018
32
A Rare Dermatologic Disease in Pregnancy: Rosacea Fulminans- Case Report and Review of the Literature. 61
30159072 2018
33
Management of necrotizing and non-necrotic bacterial erysipelas of the face in tropical areas: a series of four cases and a review of the literature. 61
30270829 2018
34
Recalcitrant psoriasiform dermatosis of the face: Is it related to pityriasis rubra pilaris? 61
29604103 2018
35
Dermoscopy of granuloma faciale: a description of a new finding. 61
33288057 2018
36
Dermoscopy of granuloma faciale: a description of a new finding. 61
30066773 2018
37
Black peel in facial dermatoses. 61
28834124 2018
38
Papulopustular rosacea and rosacea-like demodicosis: two phenotypes of the same disease? 61
29478301 2018
39
Development of Rifampicin-Indocyanine Green-Loaded Perfluorocarbon Nanodroplets for Photo-Chemo-Probiotic Antimicrobial Therapy. 61
30450048 2018
40
Rosacea in black South Africans with skin phototypes V and VI. 61
28639713 2017
41
Otophyma, Rhinophyma and Telangiectatic Rosacea - A Rare Combination in a Female Patient. 61
28785351 2017
42
The effect of skin moisture, pH, and temperature on the density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in students and staff of the Erzincan University, Turkey. 61
28369843 2017
43
Lupus Miliaris Disseminatus Faciei: Not Only a Facial Dermatosis. 61
28119995 2017
44
Misuse of Topical Corticosteroids over Face: A Clinical Study. 61
28584755 2017
45
Misuse of topical corticosteroids on facial skin. A study of 200 patients. 61
28539982 2017
46
Association study of Demodex bacteria and facial dermatoses based on DGGE technique. 61
28063008 2017
47
Two Consecutive Standardized Skin Surface Biopsies: An Improved Sampling Method to Evaluate Demodex Density as a Diagnostic Tool for Rosacea and Demodicosis. 61
27573185 2017
48
Rosacea fulminans during pregnancy. 61
29714890 2017
49
Misuse of topical corticosteroids on the face: A cross-sectional study among dermatology outpatients. 61
27559498 2016
50
Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917. 61
27340358 2016

Variations for Facial Dermatosis

Expression for Facial Dermatosis

Search GEO for disease gene expression data for Facial Dermatosis.

Pathways for Facial Dermatosis

Pathways related to Facial Dermatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
2
Show member pathways
11.85 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
3 10.42 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1

GO Terms for Facial Dermatosis

Biological processes related to Facial Dermatosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.99 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
2 transmembrane transport GO:0055085 9.97 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
3 inflammatory response GO:0006954 9.9 TRPV1 TAC1 NR1H4 MYD88
4 ion transmembrane transport GO:0034220 9.85 TRPV4 TRPV3 TRPV1 TRPA1
5 extracellular matrix disassembly GO:0022617 9.63 MMP1 KLK5 KLK4
6 sensory perception of pain GO:0019233 9.61 TRPV1 TRPA1 TAC1
7 positive regulation of calcium ion import GO:0090280 9.58 TRPV3 TRPV2
8 toll-like receptor 9 signaling pathway GO:0034162 9.58 NR1H4 MYD88
9 response to heat GO:0009408 9.58 TRPV3 TRPV2 TRPV1
10 positive regulation of ossification GO:0045778 9.56 TGFB2 TAC1
11 calcium ion transport GO:0006816 9.55 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
12 negative regulation of heart rate GO:0010459 9.54 TRPV1 TAC1
13 diet induced thermogenesis GO:0002024 9.52 TRPV4 TRPV1
14 amelogenesis GO:0097186 9.51 KLK5 KLK4
15 response to temperature stimulus GO:0009266 9.49 TRPV3 TRPV2
16 positive regulation of lymphocyte proliferation GO:0050671 9.48 TAC1 MYD88
17 response to pain GO:0048265 9.43 TRPV1 TRPA1 TAC1
18 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.37 TRPV1 TRPA1
19 calcium ion transmembrane transport GO:0070588 9.35 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
20 thermoception GO:0050955 9.32 TRPV1 TRPA1
21 calcium ion import across plasma membrane GO:0098703 8.92 TRPV4 TRPV3 TRPV2 TRPV1

Molecular functions related to Facial Dermatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 MMP1 KLK5 KLK4 CTRL
2 ion channel activity GO:0005216 9.55 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1
3 serine-type peptidase activity GO:0008236 9.54 KLK5 KLK4 CTRL
4 calcium-release channel activity GO:0015278 9.32 TRPV1 TRPA1
5 cation channel activity GO:0005261 9.26 TRPV4 TRPV3 TRPV2 TRPV1
6 calcium channel activity GO:0005262 9.02 TRPV4 TRPV3 TRPV2 TRPV1 TRPA1

Sources for Facial Dermatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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