MCID: FCL003
MIFTS: 29

Facial Hemiatrophy

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Facial Hemiatrophy

MalaCards integrated aliases for Facial Hemiatrophy:

Name: Facial Hemiatrophy 12 44 15 73
Parry-Romberg Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1757
MeSH 44 D005150
SNOMED-CT 68 29868009 95834000
UMLS 73 C0015458

Summaries for Facial Hemiatrophy

MalaCards based summary : Facial Hemiatrophy, also known as parry-romberg syndrome, is related to systemic scleroderma and heterochromia iridis, and has symptoms including ataxia and oral manifestations. An important gene associated with Facial Hemiatrophy is PRRT2 (Proline Rich Transmembrane Protein 2). The drugs Gabapentin and Chlordiazepoxide have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and eye.

Wikipedia : 76 Parry�??Romberg syndrome (also known as progressive hemifacial atrophy) is a rare disease characterized... more...

Related Diseases for Facial Hemiatrophy

Diseases related to Facial Hemiatrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 systemic scleroderma 29.4 EXOSC10 SNRNP70 TRIM21
2 heterochromia iridis 11.4
3 hemifacial atrophy, progressive 11.4
4 rasmussen encephalitis 10.5
5 intracranial aneurysm 10.4
6 external auditory canal, bilateral atresia of, with congenital vertical talus 10.3
7 retinal vasculitis 10.3
8 focal epilepsy 10.3
9 vasculitis 10.3
10 rasmussen johnsen thomsen syndrome 10.3
11 cerebral atrophy 10.3
12 rasmussen subacute encephalitis 10.3
13 degos 'en cocarde' erythrokeratoderma 10.3
14 linear scleroderma 10.3
15 dyschromatosis symmetrica hereditaria 10.2
16 poland syndrome 10.2
17 strabismus 10.2
18 torticollis 10.2
19 trigeminal neuralgia 10.2
20 3-methylglutaconic aciduria, type iii 10.2
21 retinitis pigmentosa 10.2
22 coats disease 10.2
23 stroke, ischemic 10.2
24 leber congenital amaurosis 4 10.2
25 dyschromatosis universalis hereditaria 3 10.2
26 cardiac arrest 10.2
27 optic papillitis 10.2
28 neuroretinitis 10.2
29 exotropia 10.2
30 lyme disease 10.2
31 blind hypotensive eye 10.2
32 branch retinal artery occlusion 10.2
33 central retinal artery occlusion 10.2
34 uveitis 10.2
35 retinitis 10.2
36 dystonia 10.2
37 retinal artery occlusion 10.2
38 lupus erythematosus 10.2
39 alien hand syndrome 10.2
40 anterior uveitis 10.2
41 spasmodic dysphonia 10.2
42 intracranial cysts 10.2
43 seizure disorder 10.2
44 encephalopathy 10.2
45 hemifacial spasm 10.2
46 discoid lupus erythematosus 10.2
47 skin lipoma 10.1 ARHGEF1 HMGA2
48 enterocele 10.1 ARHGEF1 SLC4A1
49 localized scleroderma 10.1
50 prolapse of female genital organ 10.1 ARHGEF1 SLC4A1

Graphical network of the top 20 diseases related to Facial Hemiatrophy:



Diseases related to Facial Hemiatrophy

Symptoms & Phenotypes for Facial Hemiatrophy

UMLS symptoms related to Facial Hemiatrophy:


ataxia, oral manifestations

Drugs & Therapeutics for Facial Hemiatrophy

Drugs for Facial Hemiatrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Chlordiazepoxide Approved, Illicit, Investigational Phase 4 58-25-3 2712
3
Ethanol Approved Phase 4 64-17-5 702
4
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
5 GABA Modulators Phase 4
6 Excitatory Amino Acid Antagonists Phase 4
7 Calcium, Dietary Phase 4,Phase 3,Phase 1
8 Anesthetics Phase 4,Phase 3
9 Central Nervous System Depressants Phase 4,Phase 3
10 Adjuvants, Anesthesia Phase 4,Phase 3
11 Anticonvulsants Phase 4,Phase 3
12 Psychotropic Drugs Phase 4,Phase 3
13 Excitatory Amino Acids Phase 4
14 Hypnotics and Sedatives Phase 4
15 calcium channel blockers Phase 4,Phase 3
16 Anti-Anxiety Agents Phase 4,Phase 3
17 Tranquilizing Agents Phase 4,Phase 3
18 GABA Agents Phase 4
19 Antiparkinson Agents Phase 4
20 Analgesics Phase 4,Phase 3
21 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
22 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
23 Antimanic Agents Phase 4
24
Levobupivacaine Approved, Investigational Phase 3 27262-47-1 92253
25
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
26
Sufentanil Approved, Investigational Phase 3 56030-54-7 41693
27
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
28
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
29
Methyltestosterone Approved Phase 3 58-18-4 6010
30
Testosterone Approved, Investigational Phase 3 58-22-0 6013
31
Testosterone enanthate Approved Phase 3 315-37-7 9416
32 Analgesics, Opioid Phase 3
33 Narcotics Phase 3
34 Anesthetics, Intravenous Phase 3
35 Anesthetics, Local Phase 3
36 Anesthetics, General Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
38 Hormones Phase 3,Phase 1
39 Hormone Antagonists Phase 3,Phase 1
40 Antineoplastic Agents, Hormonal Phase 3
41 Androgens Phase 3
42 Anabolic Agents Phase 3
43 Testosterone 17 beta-cypionate Phase 3
44
Substance P Investigational Phase 2 33507-63-0 44359816
45 Vestipitant Investigational Phase 2 334476-46-9
46 Neurokinin-1 Receptor Antagonists Phase 2
47 neurokinin A Phase 2
48
QS 21 Phase 2 141256-04-4
49 Vaccines Phase 2
50 Immunologic Factors Phase 2

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
2 Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal Completed NCT01573052 Phase 4 Chlordiazepoxide;Gabapentin
3 Deambulatory Epidural During the Labour Completed NCT02264834 Phase 3 Levobupivacaine 0.1% + Sufentanil 0.2µg/ml;Levobupivacaine 0.07% + Sufentanil 0.3µg/ml
4 Open-Label Extension Study Of Safety And Tolerability Of Pregabalin In Pediatric Patients With Partial-Onset Seizures Completed NCT00448916 Phase 3 Pregabalin
5 Efficacy of SENS-111 in Patients Suffering From Acute Unilateral Vestibulopathy Recruiting NCT03110458 Phase 2, Phase 3 SENS-111 100mg;SENS-111 200mg;Placebo Oral Tablet
6 Starting a Testosterone and Exercise Program After Hip Injury Recruiting NCT02938923 Phase 3 Testosterone;Placebo gel
7 The Effect of Human Adipose Tissue-derived MSCs in Romberg's Disease Completed NCT01309061 Phase 2
8 Vestipitant 28-day Tolerance Study Completed NCT00992160 Phase 2 GW597599;Placebo
9 Safety, Tolerability, And Immunogenicity Study Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's Disease Completed NCT00959192 Phase 2
10 Study Evaluating ACC-001 in Japanese Patients With Mild To Moderate Alzheimer's Disease Completed NCT00752232 Phase 2
11 To Evaluate The Effects Of SB-649868 (10, 30 Mg And 60 Mg) On Subjects With Primary Insomnia Completed NCT00426816 Phase 2 SB-649868;Placebo
12 Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction Not yet recruiting NCT03802396 Phase 2 CN-105;Placebo
13 A Study To Evaluate The Safety And Efficacy Of PF-04958242 In Subjects With Cognitive Impairment Associated With Schizophrenia (CIAS) Terminated NCT02855411 Phase 2 PF-04958242;placebo
14 Study to Investigate Safety, Tolerability, Pharmacokinetics and Cardiac Function After Repeat Doses of SB-649868 in Healthy-volunteers Completed NCT01030939 Phase 1 SB-649868
15 A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers. Completed NCT01299597 Phase 1 Atorvastatin;Simvastatin;SB649868
16 Effect of Different Boosting Agents on Pharmacokinetics of BILR 355 BS Dissolved in Polyethylene Glycol 400 (PEG 400) in Healthy Male Volunteers Completed NCT02257008 Phase 1 BILR 355 BS;Nelfinavir;Atazanavir;Ritonavir
17 Stability and Balance in Locomotion Through Exercise Completed NCT01856244 Phase 1
18 Bioequivalence and Food Effect Study in Healthy Volunteers Completed NCT00495274 Phase 1 Formulation A;Formulation B;Formulation C;Formulation D;Formulation E;Formulation F;Formulation G
19 A Study To Examine The Safety, Tolerability And Pharmacokinetics Of PF-02545920 In Psychiatrically Stable Subjects With Schizophrenia Completed NCT01829048 Phase 1 PF-02545920;PF-02545920;PF-02545920;Placebo
20 Multiple Ascending Doses of PF-04958242 in Subjects With Stable Schizophrenia Completed NCT02332798 Phase 1 PF-04958242;Placebo;PF-04958242;Placebo
21 Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Single Doses Of PF-04958242 In Healthy Volunteers Completed NCT02228395 Phase 1 PF-04958242;Placebo
22 A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of PF-04958242 in Healthy Subjects Completed NCT02341482 Phase 1 PF-04958242;Itraconazole
23 Role of Mesenchymal Stem Cells in Fat Grafting Unknown status NCT02494752 Not Applicable
24 Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures Unknown status NCT02777060 Not Applicable
25 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis Unknown status NCT01231009 Early Phase 1 Corticosteroids
26 Electrical Stimulation and Chemotherapy Induced Peripheral Neuropathy Unknown status NCT02088996 Not Applicable
27 Applicability of Kinect Sensor® in the Rehabilitation of Balance in the Elderly Completed NCT02436837 Not Applicable
28 Analysis of Balance in the Aging Process Completed NCT00906711
29 Strengthening in Functional Mobility of Active Elderly Completed NCT02968030 Not Applicable
30 Improving Muscle Assessment in Older Adults - The "Can We Build a Better Mouse Trap?" Study Completed NCT02295241
31 Effects of a Fall Preventive Exercise Program on Intrinsic Fall Risk Factors in Healthy Older Adults. Completed NCT01906034 Not Applicable
32 Effect of High Altitude Exposure, Acclimatization and Re-exposure on Postural Control in Lowlanders Completed NCT02730182 Not Applicable
33 Dual Task in Institutionalized Elderly Completed NCT02621697 Not Applicable
34 Impact of Xenazine(Tetrabenazine)on Gait and Functional Activity in Individuals With Huntington's Disease Completed NCT01451463
35 Characterization by Clinimetric Indicators of Chronic Low Back Pain Subjects Versus Healed Patients Completed NCT03635242 Not Applicable
36 Balance Training After Stroke With REWIRE Completed NCT03282968 Not Applicable
37 Effect of Vestibular Rehabilitation - a Randomized Controlled Trial Completed NCT00702832 Not Applicable
38 Efficacy of Eccentric Resistance Training in Persons With Knee Osteoarthritis Completed NCT02350387 Not Applicable
39 Relationship Between Musculoskeletal, Sensorimotor and Functional Factors and Nonspecific Chronic Neck Pain Completed NCT02789631
40 Effects of Feet and Ankle Mobilization on Balance of Older Adults Completed NCT03092869 Not Applicable
41 Influences of Balance Training With a Dynamometric Platform in Total Knee Arthroplasty Completed NCT02734225 Not Applicable
42 Effects of Different Exercise Programs for People With Chronic Whiplash Associated Disorders Completed NCT01528579 Not Applicable
43 Use of Whole Body Vibration in Patients With Fibromyalgia Completed NCT03782181 Not Applicable
44 Effects of Treadmill Versus Cycling Endurance Training in Patients With COPD Completed NCT03120169 Not Applicable
45 Neck Muscle Activation in Patients With Long Standing Problems After a Whiplash Trauma Registered With Ultrasound With Speckle Tracking Completed NCT01547624 Not Applicable
46 Effects of Slow-speed Traditional Resistance Training, High-speed Resistance Training and Multicomponent Training With Variable Resistances on Molecular, Body Composition, Neuromuscular, Physical Function and Quality of Life Variables in Older Adults. Completed NCT03455179 Not Applicable
47 Outcome of Physiotherapy After Surgery for Cervical Disc Disease: a Prospective Multi-Centre Trial Completed NCT01547611 Not Applicable
48 Robot Assisted Gait Training in Patients With Infratentorial Stroke Completed NCT02680691 Not Applicable
49 Wearable Biosensor to Track and Quantify Limb Dysfunction in Multiple Sclerosis Patients Recruiting NCT03369171 Not Applicable
50 Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository Recruiting NCT01808937

Search NIH Clinical Center for Facial Hemiatrophy

Cochrane evidence based reviews: facial hemiatrophy

Genetic Tests for Facial Hemiatrophy

Anatomical Context for Facial Hemiatrophy

MalaCards organs/tissues related to Facial Hemiatrophy:

41
Skin, Brain, Eye, Heart, Breast, Thyroid, Bone

Publications for Facial Hemiatrophy

Articles related to Facial Hemiatrophy:

(show top 50) (show all 251)
# Title Authors Year
1
Remission of seizures with immunosuppressive therapy in Parry-Romberg syndrome and en coup de sabre linear scleroderma: Case report and brief review of the literature. ( 30168188 )
2018
2
Ischemic Stroke in a Patient with Parry-Romberg Syndrome. ( 29031496 )
2018
3
Deep Orbital Sub-Q Hyaluronic Acid Filler Injection for Enophthalmic Sighted Eyes in Parry-Romberg Syndrome. ( 29369153 )
2018
4
An overlap case of Parry-Romberg syndrome and en coup de sabre with striking ocular involvement and anti-double-stranded DNA positivity. ( 29380800 )
2018
5
Parry-Romberg syndrome and morphoea en coup de sabre. ( 29572218 )
2018
6
Gradually Transformed: Parry-Romberg Syndrome. ( 29596787 )
2018
7
MRI findings of contralateral oculomotor nerve palsy in Parry-Romberg syndrome. ( 29780922 )
2018
8
Forehead reconstruction with a custom-made three-dimensional titanium implant in a Parry-Romberg syndrome patient. ( 29788696 )
2018
9
Changes in Cutaneous Gene Expression after Microvascular Free Tissue Transfer in Parry-Romberg Syndrome. ( 29878995 )
2018
10
Three-Dimensional Stereophotogrammetric Evaluation of the Efficacy of Autologous Fat Grafting in the Treatment of Parry-Romberg Syndrome. ( 29894458 )
2018
11
Autologous lipoinjection in Parry-Romberg syndrome. ( 30036409 )
2018
12
Tc-99m ECD Brain Perfusion Single-photon Emission Computed Tomography in Parry-Romberg Syndrome. ( 30386067 )
2018
13
Parry-Romberg syndrome in a patient with scleroderma. ( 30429134 )
2018
14
The development of multiple ocular complications in a patient with Parry-Romberg syndrome. ( 30467888 )
2018
15
Treatment of Parry-Romberg syndrome using a free flap under the SMAS - Preliminary report of a first case. ( 30509689 )
2018
16
Parry Romberg syndrome presenting with a giant intracranial aneurysm: a case report. ( 28580154 )
2017
17
Parry-Romberg Syndrome on a Major French Revolution Leader: Mirabeau, 1791. ( 27617816 )
2017
18
A Novel Method of Mild to Moderate Parry-Romberg Syndrome Reconstruction: Computer-Assisted Surgery With Mandibular Outer Cortex and Fat Grafting. ( 27997449 )
2017
19
Brain Glucose Metabolism in Parry-Romberg Syndrome. ( 28166152 )
2017
20
Facial Myokymias In Parry-Romberg Syndrome. ( 28400908 )
2017
21
Parry Romberg Syndrome and linear facial scleroderma: management in pediatric population. ( 28691464 )
2017
22
Parry-Romberg syndrome: conventional and advanced MRI follow-up in a boy. ( 28786747 )
2017
23
Parry-romberg syndrome: about a case. ( 28819507 )
2017
24
Tongue Involvement in Parry-Romberg Syndrome. ( 28864667 )
2017
25
Clinical and radiographic features of parry-romberg syndrome. ( 29114430 )
2017
26
Evaluating Autologous Lipofilling for Parry-Romberg Syndrome-Associated Defects: A Systematic Literature Review and Case Report. ( 26295800 )
2016
27
Ophthalmological manifestations of Parry-Romberg syndrome. ( 27045226 )
2016
28
Late progression of neurological symptoms and MRI T2 hyperintensities in Parry-Romberg syndrome. ( 27071645 )
2016
29
Difficult mask ventilation made easy: Three cases of Parry Romberg syndrome. ( 27141113 )
2016
30
"The Unkindest Cut of All": Parry-Romberg Syndrome - An Unwonted Affair. ( 27437327 )
2016
31
Parry-Romberg syndrome affecting one half of the body. ( 27583230 )
2016
32
The Chronic Encephalopathy of Parry Romberg Syndrome and En Coupe De Sabre with a 31-Year-History in a West Indian Woman: Clinical, Immunologic and Neuroimaging Abnormalities. ( 27761227 )
2016
33
Lower limb onset Parry-Romberg syndrome: an unusual presentation of a rare disease. ( 29497540 )
2016
34
Overlap between linear scleroderma, progressive facial hemiatrophy and immune-inflammatory encephalitis in a paediatric cohort. ( 25851111 )
2015
35
Parry-Romberg syndrome: a case with a possible association with Lyme disease. ( 26697732 )
2015
36
CNS imaging findings associated with Parry-Romberg syndrome and en coup de sabre: correlation to dermatologic and neurologic abnormalities. ( 25304124 )
2015
37
Trigeminal involvement in parry-romberg syndrome: an in vivo confocal microscopy study of the cornea. ( 25742391 )
2015
38
Oral manifestations of Parry-Romberg syndrome: A review of literature. ( 25878963 )
2015
39
Parry Romberg Syndrome: 7 Cases and Literature Review. ( 26066627 )
2015
40
Neurological Manifestations in Parry-Romberg Syndrome: 2 Case Reports. ( 26181554 )
2015
41
Parry-Romberg syndrome associated with complete agenesis of the corpus callosum: An uncommon case report. ( 26253022 )
2015
42
Parry Romberg syndrome with a wide range of ocular manifestations: a case report. ( 26340917 )
2015
43
Treating Parry-Romberg Syndrome Using Three-Dimensional Scanning and Printing and the Anterolateral Thigh Dermal Adipofascial Flap. ( 26355969 )
2015
44
Parry-Romberg syndrome. Physical, clinical, and imaging features. ( 26492117 )
2015
45
Central retinal artery occlusion in a child with Parry-Romberg syndrome. ( 24513383 )
2014
46
Parry-Romberg syndrome vasculopathy and its treatment with botulinum toxin. ( 23719195 )
2014
47
Total mandibular subapical osteotomy and Le Fort I osteotomy using piezosurgery and computer-aided designed and manufactured surgical splints: a favorable combination of three techniques in the management of severe mouth asymmetry in Parry-Romberg syndrome. ( 24280170 )
2014
48
Parry-Romberg syndrome with rare maxillofacial deformities: a report on two cases. ( 24359863 )
2014
49
Parry-Romberg syndrome studied by spectral-domain optical coherence tomography. ( 24477334 )
2014
50
Corneal findings in Parry-Romberg syndrome. ( 24513374 )
2014

Variations for Facial Hemiatrophy

Expression for Facial Hemiatrophy

Search GEO for disease gene expression data for Facial Hemiatrophy.

Pathways for Facial Hemiatrophy

GO Terms for Facial Hemiatrophy

Sources for Facial Hemiatrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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