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MCID: FCL011
MIFTS: 37

Facial Nerve Disease

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Facial Nerve Disease

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MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 12 15 17
Facial Nerve Diseases 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1756
ICD9CM 34 351 351.9
MeSH 43 D005155
NCIt 49 C27594
SNOMED-CT 67 90039006
ICD10 32 G51 G51.8 G51.9
UMLS 71 C0015464
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Summaries for Facial Nerve Disease

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MalaCards based summary : Facial Nerve Disease, also known as facial nerve diseases, is related to geniculate ganglionitis and moebius syndrome, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is MARVELD1 (MARVEL Domain Containing 1), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Primary immunodeficiency. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include bone, tongue and pons, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 74 The facial nerve is the seventh cranial nerve, or simply CN VII. It emerges from the pons of the... more...

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Related Diseases for Facial Nerve Disease

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Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 geniculate ganglionitis 11.4
2 moebius syndrome 11.0
3 petrous apex meningioma 10.6 KANTR ANTXR2
4 alkhurma hemorrhagic fever 10.6 CD40LG ANTXR2
5 foramen magnum meningioma 10.6 KANTR ANTXR2
6 anterior cranial fossa meningioma 10.6 NF2 ANTXR2
7 glossopharyngeal neuralgia 10.6 KANTR ANTXR2
8 orbital plasma cell granuloma 10.6 CRP CD40LG
9 premenstrual tension 10.6 MTRNR2L5 LIPN
10 ametropic amblyopia 10.5 MTRNR2L5 MTRNR2L4
11 cerebellopontine angle tumor 10.5 NF2 ANTXR2
12 cerebral falx meningioma 10.5 NF2 KANTR ANTXR2
13 japanese spotted fever 10.5 CRP CD40LG
14 latent syphilis 10.5 CD40LG CD4
15 gastroduodenitis 10.5 CD40LG CD4
16 mediastinum teratoma 10.5 CRP ACE
17 primary syphilis 10.5 CD40LG CD4
18 asymptomatic neurosyphilis 10.5 CD40LG CD4
19 acute dacryoadenitis 10.5 CRP ACE
20 tertiary neurosyphilis 10.5 CD40LG CD4
21 fournier gangrene 10.5 CD40LG ALB
22 transient arthritis 10.5 CD40LG CD4
23 glossopharyngeal nerve disease 10.5 KANTR CRP ANTXR2
24 heterophyiasis 10.5 CD40LG ALB
25 cavernous sinus thrombosis 10.5 KANTR CRP
26 pericardial tuberculosis 10.5 CRP CD4
27 non-secretory myeloma 10.5 CD40LG ALB
28 chronic duodenal ileus 10.5 CRP ALB
29 ventilation pneumonitis 10.5 CD8A CD4
30 paralytic squint 10.5 MTRNR2L5 KIF21A
31 multiple cranial nerve palsy 10.5 CRP ACE
32 anterior scleritis 10.5 CRP ACE
33 posterior scleritis 10.5 CRP ACE
34 tolosa-hunt syndrome 10.5 CRP ACE
35 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
36 mononeuritis of upper limb and mononeuritis multiplex 10.5 CRP CD40LG CD4
37 mononeuritis multiplex 10.5 CRP CD40LG CD4
38 autoimmune lymphoproliferative syndrome, type iia 10.5 CD8A CD4
39 chronic meningitis 10.4 CRP CD40LG CD4
40 chlamydia pneumonia 10.4 CRP CD40LG CD4
41 vaginal discharge 10.4 CRP CD40LG CD4
42 epididymis disease 10.4 CRP CD40LG CD4
43 chromosome 14q11-q22 deletion syndrome 10.4 CD8A CD4
44 diabetes mellitus, insulin-dependent, 23 10.4 CD8A CD4
45 intracranial sinus thrombosis 10.4 CRP CD40LG
46 urethritis 10.4 CRP CD40LG CD4
47 lassa fever 10.4 CD8A CD40LG ANTXR2
48 granulomatous dermatitis 10.4 CD40LG CD4 ACE
49 chronic orbital inflammation 10.4 CRP CD40LG ACE
50 bird fancier's lung 10.4 CD8A CD4

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease
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Symptoms & Phenotypes for Facial Nerve Disease

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UMLS symptoms related to Facial Nerve Disease:


oral manifestations, facial paresis, numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 ALB ANKH ANTXR2 CADM1 CD4 CD40LG
2 endocrine/exocrine gland MP:0005379 9.61 ACE ALB CADM1 CD4 CD40LG CD8A
3 immune system MP:0005387 9.36 ACE ALB ANKH ANTXR2 CADM1 CD4
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Drugs & Therapeutics for Facial Nerve Disease

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Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7
Cortisone Experimental Phase 4 53-06-5 222786
8 Methylprednisolone Acetate Phase 4
9 Protective Agents Phase 4
10 Neuroprotective Agents Phase 4
11
Prednisone Approved, Vet_approved 53-03-2 5865
12
Lamotrigine Approved, Investigational 84057-84-1 3878
13
tannic acid Approved 1401-55-4
14
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
15
Gabapentin Approved, Investigational 60142-96-3 3446
16
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
17
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
18
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
19
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
20
Calcium Approved, Nutraceutical 7440-70-2 271
21 Antipsychotic Agents
22 Central Nervous System Depressants
23 Sodium Channel Blockers
24 Anticonvulsants
25 calcium channel blockers
26 Calcium, Dietary
27 Tranquilizing Agents
28 Psychotropic Drugs
29 Diuretics, Potassium Sparing
30 Keratolytic Agents
31 Dermatologic Agents
32 Antifungal Agents
33 Anti-Infective Agents
34 Hormones
35 Gastrointestinal Agents
36 Antiemetics
37 Anti-Inflammatory Agents
38 Hormone Antagonists
39 Autonomic Agents
40 Antineoplastic Agents, Hormonal
41 glucocorticoids
42 Pharmaceutical Solutions
43 BB 1101

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
2 Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla. Active, not recruiting NCT03496025 Phase 1
3 Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China Unknown status NCT01201642 Prednisolone
4 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Lamotrigine;Placebo (for Lamotrigine)
5 The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery Completed NCT02489162
6 Neuro Occlusal Rehabilitation in Patient With Peripheral Facial Paralysis - a Randomized Clinical Trial Completed NCT01327157
7 Imaging of Facial Neuritis Using T2-weighted Gradient-echo Fast Imaging Employing Steady State Acquisition After Gadolinium Injection Recruiting NCT03543384
8 Intratympanic Stereoidal Injections for Facial Nerve Palsy Not yet recruiting NCT03371589 Dexamethasone

Search NIH Clinical Center for Facial Nerve Disease

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Genetic Tests for Facial Nerve Disease

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Anatomical Context for Facial Nerve Disease

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MalaCards organs/tissues related to Facial Nerve Disease:

40
Bone, Tongue, Pons, Lung, B Cells, Eye, Thymus
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Publications for Facial Nerve Disease

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Articles related to Facial Nerve Disease:

(show all 17)
# Title Authors PMID Year
1
[The progress of glucocorticoids via postauricular injection in treatment of sudden hearing loss]. 61
29871146 2016
2
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. 61
26889221 2016
3
Reference values for dynamic facial muscle ultrasonography in adults. 61
24519557 2014
4
The minimally invasive, orbicularis-sparing, lower eyelid recession for mild to moderate lower eyelid retraction with reduced orbicularis strength. 61
24434916 2014
5
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. 61
23682941 2013
6
Idiopathic tinnitus concomitant with eye closure. 61
22215457 2012
7
[Anomaly of infrared thermal radiation intensity on unilateral mild to moderate Bell's palsy]. 61
21800579 2011
8
Features of facial asymmetry following incomplete recovery from facial paralysis. 61
20879064 2010
9
[Electrophysiological examination of the cranial nerves: technical aspects and practical applications]. 61
15244162 2004
10
Cortical representation of the orbicularis oculi muscle as assessed by transcranial magnetic stimulation (TMS). 61
11801987 2001
11
[The normal value and clinical applications of the blink reflex]. 61
11938846 1998
12
Crossed R1 response of the blink reflex in peripheral facial palsy. 61
7781575 1995
13
3D-FT MRI of the facial nerve. 61
7991093 1994
14
[Intratemporal course of the facial nerve in magnetic resonance imaging]. 61
2917878 1989
15
MR imaging of the intratemporal facial nerve by using surface coils. 61
3492891 1987
16
Neuromyography in the diagnostics of Bell's palsy. 61
6475422 1984
17
[Significance of the intermediate nerve for topical diagnosis of the facial nerve disease]. 61
13620136 1958
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Variations for Facial Nerve Disease

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Expression for Facial Nerve Disease

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Search GEO for disease gene expression data for Facial Nerve Disease.
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Pathways for Facial Nerve Disease

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Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell adhesion molecules (CAMs) 36
11.42 CD8A CD40LG CD4 CADM1
2
Primary immunodeficiency 36
10.38 CD8A CD40LG CD4
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GO Terms for Facial Nerve Disease

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Cellular components related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 MTRNR2L5 MTRNR2L4 LIPN CRP CD8A CD40LG
2 external side of plasma membrane GO:0009897 9.02 CD8A CD40LG CD4 ANTXR2 ACE
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Sources for Facial Nerve Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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