Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: FCL011
MIFTS: 36

Facial Nerve Disease

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Facial Nerve Disease

About this section

MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 12 15
Facial Nerve Diseases 73

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1756
ICD10 33 G51 G51.9
ICD9CM 35 351 351.9
MeSH 44 D005155
NCIt 50 C27594
UMLS 73 C0015464
Sources

Summaries for Facial Nerve Disease

About this section
MalaCards based summary : Facial Nerve Disease, also known as facial nerve diseases, is related to geniculate ganglionitis and moebius syndrome, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways is N-cadherin signaling events. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, trigeminal ganglion and skin, and related phenotypes are cellular and mortality/aging

Sources

Related Diseases for Facial Nerve Disease

About this section

Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 geniculate ganglionitis 11.1
2 moebius syndrome 10.7
3 bell's palsy 10.7 HOXB1 LIPN
4 asthenopia 10.6 CADM1 LIPN
5 amyloid tumor 10.6 NF2 TUBB3
6 poland syndrome 10.4 HOXA2 TUBB3
7 trench fever 10.4 CD40LG KANTR
8 cerebral arteritis 10.4 CD40LG KANTR
9 congenital ptosis 10.4 KIF21A TUBB3
10 geniculate herpes zoster 10.4 CD40LG KANTR
11 japanese spotted fever 10.4 CD40LG KANTR
12 foramen magnum meningioma 10.4 KANTR NF2
13 facial hemiatrophy 10.4 CD40LG KANTR
14 brachial plexus neuritis 10.4 CD40LG KANTR
15 deafness, autosomal dominant 28 10.3 KIF21A TUBB3
16 exposure keratitis 10.3 KANTR TUBB3
17 polyneuropathy 10.3 CD40LG GSN TUBB3
18 anterior cranial fossa meningioma 10.3 KANTR NF2
19 functional colonic disease 10.2 CD40LG KANTR
20 branch retinal artery occlusion 10.2 CD40LG KANTR
21 central nervous system disease 10.1 CD40LG KANTR TUBB3
22 nervous system disease 10.1 CD40LG KANTR TUBB3
23 fibrosis of extraocular muscles, congenital, 2 10.1 KIF21A PHOX2A
24 cerebellopontine angle tumor 10.1 KANTR NF2
25 colonic pseudo-obstruction 10.1 CD40LG KANTR
26 neurofibromatosis, type ii 10.0 CADM1 NF2
27 premenstrual tension 10.0 KANTR LIPN LRP5
28 extrinsic cardiomyopathy 10.0 CD40LG KANTR
29 hypertropia 10.0 KANTR KIF21A TUBB3
30 exotropia 9.9 KIF21A PHOX2A TUBB3
31 ocular motility disease 9.8 KIF21A PHOX2A TUBB3
32 kearns-sayre syndrome 9.8 KIF21A PHOX2A TUBB3
33 ptosis 9.8 KIF21A PHOX2A TUBB3
34 duane retraction syndrome 9.8 KIF21A TUBB3
35 peripheral nervous system disease 9.6 CD40LG KANTR KIF21A TUBB3
36 tukel syndrome 9.5 HOXB1 KIF21A PHOX2A TUBB3
37 strabismus 9.5 HOXB1 KIF21A PHOX2A TUBB3
38 hypotropia 9.2 KANTR KIF21A PHOX2A TUBB3
39 paralytic squint 8.9 CADM1 KANTR KIF21A PHOX2A TUBB3
40 cranial nerve disease 8.0 KANTR KIF21A LIPN MARVELD1 PHOX2A TUBB3
41 facial paralysis 6.5 ANKH CADM1 CD40LG GSN HOXA2 HOXB1

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease
Sources

Symptoms & Phenotypes for Facial Nerve Disease

About this section

UMLS symptoms related to Facial Nerve Disease:


oral manifestations, facial paresis, numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 ANKH CADM1 CD40LG GSN HOXA2 HOXB1
2 mortality/aging MP:0010768 9.91 ANKH CD40LG GSN HOXA2 HOXB1 LRP5
3 nervous system MP:0003631 9.81 CADM1 CD40LG GSN HOXA2 HOXB1 LRP5
4 craniofacial MP:0005382 9.72 LRP5 NF2 ANKH HOXA2 HOXB1
5 respiratory system MP:0005388 9.5 TUBB3 ANKH GSN HOXA2 HOXB1 NF2
6 skeleton MP:0005390 9.17 ANKH CD40LG GSN HOXA2 HOXB1 LRP5
Sources

Drugs & Therapeutics for Facial Nerve Disease

About this section

Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
3
Acetylcholine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
4
Acyclovir Approved Phase 4,Not Applicable 59277-89-3 2022
5
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3 298-46-4 2554
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
7
Ondansetron Approved Phase 4 99614-02-5 4595
8
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
9
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
10
Oxcarbazepine Approved Phase 4 28721-07-5 34312
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Antiemetics Phase 4,Phase 3,Not Applicable
13 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
14 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
15 Autonomic Agents Phase 4,Phase 3,Not Applicable
16 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
17 glucocorticoids Phase 4,Phase 3,Not Applicable
18 Hormone Antagonists Phase 4,Phase 3,Not Applicable
19 Hormones Phase 4,Phase 3,Not Applicable
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
21 Methylprednisolone acetate Phase 4,Phase 3,Not Applicable
22 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Not Applicable
23 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Prednisolone acetate Phase 4,Phase 3,Not Applicable
25 Prednisolone hemisuccinate Phase 4,Phase 3,Not Applicable
26 Prednisolone phosphate Phase 4,Phase 3,Not Applicable
27 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Botulinum Toxins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 incobotulinumtoxinA Phase 4,Phase 2
33 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
34 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 onabotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
37 Anti-Infective Agents Phase 4,Not Applicable
38 Antiviral Agents Phase 4,Not Applicable
39 valacyclovir Phase 4,Not Applicable
40 Anesthetics Phase 4,Not Applicable
41 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
42 Dermatologic Agents Phase 4,Not Applicable
43 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
44 Excitatory Amino Acids Phase 4,Phase 2,Phase 3,Not Applicable
45 Psychotropic Drugs Phase 4,Phase 2,Phase 3
46 Tranquilizing Agents Phase 4,Phase 2,Phase 3
47 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
48 Anticonvulsants Phase 4,Phase 2,Phase 3,Not Applicable
49 Antimanic Agents Phase 4,Phase 2,Phase 3
50 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 94)
# Name Status NCT ID Phase Drugs
1 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
2 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
4 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
5 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
6 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
7 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
8 Intratympanic Steroid for Bell's Palsy Recruiting NCT03508440 Phase 2, Phase 3 Prednisone
9 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
10 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
11 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
12 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
13 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
14 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
15 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
16 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
17 Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children Completed NCT01777633 Phase 1, Phase 2
18 The Effect of Human Adipose Tissue-derived MSCs in Romberg's Disease Completed NCT01309061 Phase 2
19 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
20 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
21 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
22 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
23 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Active, not recruiting NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
24 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
25 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
26 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
27 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
28 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
29 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Not Applicable Prednisolone
30 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
31 Role of Mesenchymal Stem Cells in Fat Grafting Unknown status NCT02494752 Not Applicable
32 Treatment of Chronic Myofascial Pain Syndrome Over Neck by Using Intravascular Laser Irradiation of Blood Unknown status NCT02470000 Not Applicable
33 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598 Not Applicable
34 The Effect of Low Level Laser Therapy (LLLT) in Myofacial Pain Syndrome Unknown status NCT01417637 Not Applicable
35 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
36 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
37 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
38 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Not Applicable Lamotrigine
39 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157 Not Applicable
40 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
41 MDs on Botox Utility (MOBILITY) Completed NCT00535938
42 Impairments of Oral Language in Mobius Syndrome Completed NCT00856531
43 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
44 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
45 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
46 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
47 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226 Not Applicable
48 Complications in Parotid Surgery Completed NCT02486393
49 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079 Not Applicable Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
50 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine

Search NIH Clinical Center for Facial Nerve Disease

Sources

Genetic Tests for Facial Nerve Disease

About this section
Sources

Anatomical Context for Facial Nerve Disease

About this section

MalaCards organs/tissues related to Facial Nerve Disease:

41
Testes, Trigeminal Ganglion, Skin, Liver, Bone, Cortex, Eye
Sources

Publications for Facial Nerve Disease

About this section

Articles related to Facial Nerve Disease:

# Title Authors Year
1
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. ( 23682941 )
2013
Sources

Variations for Facial Nerve Disease

About this section
Sources

Expression for Facial Nerve Disease

About this section
Search GEO for disease gene expression data for Facial Nerve Disease.
Sources

Pathways for Facial Nerve Disease

About this section

Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
N-cadherin signaling events 1
10.14 GSN LRP5
Sources

GO Terms for Facial Nerve Disease

About this section

Cellular components related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cortical actin cytoskeleton GO:0030864 8.62 GSN NF2

Biological processes related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of osteoblast differentiation GO:0045668 9.16 HOXA2 LRP5
2 osteoblast development GO:0002076 8.96 HOXA2 LRP5
3 anterior/posterior pattern specification GO:0009952 8.8 HOXA2 HOXB1 LRP5
Sources

Sources for Facial Nerve Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....