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MCID: FCL011
MIFTS: 38

Facial Nerve Disease

Categories: Neuronal diseases, Smell/Taste diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Facial Nerve Disease

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MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 12 29 15 17
Facial Nerve Diseases 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Smell/Taste diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1756
ICD9CM 34 351
MeSH 44 D005155
NCIt 50 C27594
SNOMED-CT 67 90039006
ICD10 32 G51 G51.8 G51.9
UMLS 71 C0015464
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Summaries for Facial Nerve Disease

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MalaCards based summary : Facial Nerve Disease, also known as facial nerve diseases, is related to moebius syndrome and hordeolum, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is MARVELD1 (MARVEL Domain Containing 1), and among its related pathways/superpathways are Folate Metabolism and Innate Lymphoid Cell Differentiation Pathways. The drugs Prednisolone acetate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include pons, tongue and eye, and related phenotypes are cellular and immune system

Wikipedia : 74 The facial nerve (the labyrinthine segment) is the seventh cranial nerve, or simply CN VII. It emerges... more...

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Related Diseases for Facial Nerve Disease

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Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 467)
# Related Disease Score Top Affiliating Genes
1 moebius syndrome 10.9
2 hordeolum 10.4 MTRNR2L5 CD4
3 ametropic amblyopia 10.4 MTRNR2L5 MTRNR2L4
4 premenstrual tension 10.4 MTRNR2L5 LIPN
5 suppression amblyopia 10.4 MTRNR2L5 MTRNR2L4
6 riedel's fibrosing thyroiditis 10.4 CD4 ALB
7 acute dacryoadenitis 10.4 CRP ACE
8 panophthalmitis 10.4 CRP CD4
9 mediastinum teratoma 10.4 CRP ACE
10 cardiac tuberculosis 10.4 CRP ACE
11 necrotic uveal melanoma 10.4 CD8A CD4
12 chronic duodenal ileus 10.4 CRP ALB
13 paralytic squint 10.4 MTRNR2L5 KIF21A
14 ocular tuberculosis 10.3 CD4 ACE
15 purulent acute otitis media 10.3 PRTN3 CRP
16 early yaws 10.3 CD8A CD4
17 ventilation pneumonitis 10.3 CD8A CD4
18 facial hemiatrophy 10.3 KIF21A CRP
19 wissler-fanconi syndrome 10.3 PRTN3 CD4
20 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
21 pericardial tuberculosis 10.3 CRP CD4
22 urogenital tuberculosis 10.3 CRP CD4
23 latent syphilis 10.3 CD8A CD4
24 peptic ulcer perforation 10.3 CRP ALB
25 frontal sinusitis 10.3 PRTN3 CRP
26 neurofibromatosis, type ii 10.3 NF2 DCAF8 CADM1
27 ankylosing spondylitis 3 10.3 CRP ALB
28 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
29 ankylosing spondylitis 1 10.3 CRP ALB
30 orthostatic proteinuria 10.3 ALB ACE
31 orbital plasma cell granuloma 10.3 PRTN3 CRP
32 bicipital tenosynovitis 10.3 PRTN3 CRP
33 tuberculous peritonitis 10.3 CRP ALB
34 glomerular disease 10.3 ALB ACE
35 silent myocardial infarction 10.3 CRP ACE
36 parapsoriasis 10.3 CD8A CD4
37 ethmoid sinusitis 10.3 PRTN3 CRP
38 gastroduodenitis 10.3 CD8A CD4
39 drug reaction with eosinophilia and systemic symptoms 10.3 TNF CRP
40 pyomyositis 10.3 CRP CD4
41 chronic intestinal vascular insufficiency 10.3 CRP ALB
42 suppurative lymphadenitis 10.3 CRP CD4
43 norwegian scabies 10.3 CD8A CD4
44 bird fancier's lung 10.3 CD8A CD4
45 urinary tract infection 10.3 CRP ACE
46 neuroretinitis 10.3 CRP CD4 ACE
47 cerebral falx meningioma 10.3 PLG NF2
48 optic papillitis 10.3 CRP CD4 ACE
49 cat-scratch disease 10.3 CRP CD4 ACE
50 orbital cellulitis 10.3 CRP CD4

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease
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Symptoms & Phenotypes for Facial Nerve Disease

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UMLS symptoms related to Facial Nerve Disease:


oral manifestations, facial paresis, numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.77 ALB ANKH CADM1 CD4 CD82 CD8A
2 immune system MP:0005387 9.44 ACE ALB ANKH CADM1 CD4 CD8A
Sources

Drugs & Therapeutics for Facial Nerve Disease

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Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7
Cortisone Experimental Phase 4 53-06-5 222786
8 Anti-Inflammatory Agents Phase 4
9 Hormone Antagonists Phase 4
10 glucocorticoids Phase 4
11 Methylprednisolone Acetate Phase 4
12 Hormones Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14
Prednisone Approved, Vet_approved 53-03-2 5865
15
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
16
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
17
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
18
Clotrimazole Approved, Vet_approved 23593-75-1 2812
19
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
20
Lidocaine Approved, Vet_approved 137-58-6 3676
21
Prilocaine Approved 721-50-6 4906
22
tannic acid Approved 1401-55-4
23
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
24
Gabapentin Approved, Investigational 60142-96-3 3446
25
Lamotrigine Approved, Investigational 84057-84-1 3878
26 Gastrointestinal Agents
27 Antiemetics
28 Antifungal Agents
29 Keratolytic Agents
30 Anti-Infective Agents
31 Dermatologic Agents
32 Insulin, Globin Zinc
33 Pharmaceutical Solutions
34 insulin
35 Anticonvulsants
36 Sodium Channel Blockers
37 Psychotropic Drugs
38 Antipsychotic Agents
39 Diuretics, Potassium Sparing
40 Calcium, Dietary
41 calcium channel blockers
42
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
2 Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla. Active, not recruiting NCT03496025 Phase 1
3 Imaging of Facial Neuritis Using T2-weighted Gradient-echo Fast Imaging Employing Steady State Acquisition After Gadolinium Injection Unknown status NCT03543384
4 Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China Unknown status NCT01201642 Prednisolone
5 Intratympanic Stereoidal Injections for Facial Nerve Palsy Unknown status NCT03371589 Dexamethasone
6 Neuro Occlusal Rehabilitation in Patient With Peripheral Facial Paralysis - a Randomized Clinical Trial Completed NCT01327157
7 The Role of Collagen in the Rehabilitation of Peripheral Paralysis of the Facial Nerve Completed NCT04353908
8 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Lamotrigine;Placebo (for Lamotrigine)
9 The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery Completed NCT02489162

Search NIH Clinical Center for Facial Nerve Disease

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Genetic Tests for Facial Nerve Disease

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Genetic tests related to Facial Nerve Disease:

# Genetic test Affiliating Genes
1 Facial Nerve Disease 29
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Anatomical Context for Facial Nerve Disease

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MalaCards organs/tissues related to Facial Nerve Disease:

40
Pons, Tongue, Eye
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Publications for Facial Nerve Disease

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Articles related to Facial Nerve Disease:

(show all 19)
# Title Authors PMID Year
1
Peripheral facial paralysis as presenting symptom of COVID-19 in a pregnant woman. 61
32784234 2020
2
Facial nerve electrodiagnostics for patients with facial palsy: a clinical practice guideline. 61
32270328 2020
3
[The progress of glucocorticoids via postauricular injection in treatment of sudden hearing loss]. 61
29871146 2016
4
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. 61
26889221 2016
5
Reference values for dynamic facial muscle ultrasonography in adults. 61
24519557 2014
6
The minimally invasive, orbicularis-sparing, lower eyelid recession for mild to moderate lower eyelid retraction with reduced orbicularis strength. 61
24434916 2014
7
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. 61
23682941 2013
8
Idiopathic tinnitus concomitant with eye closure. 61
22215457 2012
9
[Anomaly of infrared thermal radiation intensity on unilateral mild to moderate Bell's palsy]. 61
21800579 2011
10
Features of facial asymmetry following incomplete recovery from facial paralysis. 61
20879064 2010
11
[Electrophysiological examination of the cranial nerves: technical aspects and practical applications]. 61
15244162 2004
12
Cortical representation of the orbicularis oculi muscle as assessed by transcranial magnetic stimulation (TMS). 61
11801987 2001
13
[The normal value and clinical applications of the blink reflex]. 61
11938846 1998
14
Crossed R1 response of the blink reflex in peripheral facial palsy. 61
7781575 1995
15
3D-FT MRI of the facial nerve. 61
7991093 1994
16
[Intratemporal course of the facial nerve in magnetic resonance imaging]. 61
2917878 1989
17
MR imaging of the intratemporal facial nerve by using surface coils. 61
3492891 1987
18
Neuromyography in the diagnostics of Bell's palsy. 61
6475422 1984
19
[Significance of the intermediate nerve for topical diagnosis of the facial nerve disease]. 61
13620136 1958
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Variations for Facial Nerve Disease

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Expression for Facial Nerve Disease

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Search GEO for disease gene expression data for Facial Nerve Disease.
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Pathways for Facial Nerve Disease

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Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.26 TNF PLG CRP ALB
2
Innate Lymphoid Cell Differentiation Pathways 64
11.23 TNF CD8A CD4
3
Dendritic Cells Developmental Lineage Pathway 64
11 TNF CD8A CD4
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GO Terms for Facial Nerve Disease

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Cellular components related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.36 TNF SOST PRTN3 PLG MTRNR2L5 MTRNR2L4

Biological processes related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of lipid storage GO:0010888 8.96 TNF CRP
2 negative regulation of signaling receptor activity GO:2000272 8.8 MTRNR2L4 MTRNR2L5 TNF
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Sources for Facial Nerve Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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