MCID: FCL011
MIFTS: 38

Facial Nerve Disease

Categories: Neuronal diseases
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Aliases & Classifications for Facial Nerve Disease

MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 11 14 16
Disorders of the Seventh Cranial Nerve 33
Disorders of 7th Cranial Nerve 33
Neuropathy of Facial Nerve 33
Facial Nerve Disorder 28
Facial Nerve Diseases 71

Classifications:



External Ids:

Disease Ontology 11 DOID:1756
ICD9CM 34 351
MeSH 43 D005155
NCIt 49 C27594
SNOMED-CT 68 90039006
ICD10 31 G51 G51.8 G51.9
UMLS 71 C0015464

Summaries for Facial Nerve Disease

MalaCards based summary: Facial Nerve Disease, also known as disorders of the seventh cranial nerve, is related to bell's palsy and moebius syndrome, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is MARVELD1 (MARVEL Domain Containing 1), and among its related pathways/superpathways are Innate Lymphoid Cells Differentiation and Dendritic Cells Developmental Lineage Pathway. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are endocrine/exocrine gland and cellular

Related Diseases for Facial Nerve Disease

Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 596)
# Related Disease Score Top Affiliating Genes
1 bell's palsy 28.6 TNF MTRNR2L5 MARVELD1 LIPN KANTR HOXB1
2 moebius syndrome 11.0
3 foramen magnum meningioma 10.4 NF2 KANTR
4 premenstrual tension 10.4 MTRNR2L5 LIPN
5 syphilitic meningitis 10.4 CRP CD4
6 mediastinum teratoma 10.4 CRP ACE
7 pineal region meningioma 10.4 NF2 CRP
8 panophthalmitis 10.4 CRP CD4
9 vertebrobasilar insufficiency 10.4 LIPN CRP
10 intracranial abscess 10.4 CRP CD4
11 uveoparotid fever 10.4 CD4 ACE
12 chronic duodenal ileus 10.4 CRP ALB
13 hilar lung neoplasm 10.4 CD8A CD4
14 purulent endophthalmitis 10.4 CRP CD4
15 supratentorial meningioma 10.4 NF2 AQP4
16 cerebellopontine angle tumor 10.4 NF2 KANTR FKBP4
17 acute dacryoadenitis 10.4 MOG CRP
18 klebsiella pneumonia 10.4 CRP ALB
19 ocular tuberculosis 10.4 CD4 ACE
20 subdural empyema 10.4 KANTR CRP
21 subclavian steal syndrome 10.4 CRP ACE
22 pyomyositis 10.4 CRP CD4
23 ankylosing spondylitis 3 10.4 CRP ALB
24 oral tuberculosis 10.4 CD8A CD4
25 early yaws 10.4 CD8A CD4
26 renal tuberculosis 10.4 CRP ALB
27 internal hordeolum 10.4 MTRNR2L5 ACE
28 breast abscess 10.4 CRP CD4
29 silent myocardial infarction 10.4 CRP ACE
30 brain stem infarction 10.4 LIPN CRP
31 refractive amblyopia 10.4 MTRNR2L5 MTRNR2L4
32 vascular myelopathy 10.4 MOG AQP4
33 intermittent proptosis 10.3 MOG AQP4
34 tuberculous encephalopathy 10.3 MOG AQP4
35 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
36 chronic intestinal vascular insufficiency 10.3 CRP ALB
37 wissler-fanconi syndrome 10.3 CD8A CD4
38 acute vascular insufficiency of intestine 10.3 CRP ALB
39 hypertensive nephropathy 10.3 ALB ACE
40 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
41 peptic ulcer perforation 10.3 CRP ALB
42 multiple cranial nerve palsy 10.3 CRP CD4 ACE
43 petrous apex meningioma 10.3 NF2 KANTR AQP4
44 encephalitozoonosis 10.3 CD8A CD4
45 cat-scratch disease 10.3 CRP CD4 ACE
46 coronary artery vasospasm 10.3 KANTR CRP ACE
47 tuberculous peritonitis 10.3 CRP ALB
48 febrile seizures, familial, 5 10.3 ACE2 ACE
49 orthostatic proteinuria 10.3 ALB ACE
50 urogenital tuberculosis 10.3 CRP CD4 ALB

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease

Symptoms & Phenotypes for Facial Nerve Disease

UMLS symptoms related to Facial Nerve Disease:


oral manifestations; facial paresis; numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 ACE ALB AQP4 CADM1 CD4 CD8A
2 cellular MP:0005384 9.77 ACE ACE2 ALB CADM1 CD4 CD82
3 immune system MP:0005387 9.47 ACE ACE2 ALB AQP4 CADM1 CD4

Drugs & Therapeutics for Facial Nerve Disease

Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
6
Apraclonidine Approved Phase 4 66711-21-5 2216
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
8
Cortisone Experimental Phase 4 53-06-5 222786
9 Antineoplastic Agents, Hormonal Phase 4
10 Hormones Phase 4
11 Hormone Antagonists Phase 4
12 glucocorticoids Phase 4
13 Anti-Inflammatory Agents Phase 4
14
Methylprednisolone Acetate Phase 4 584547
15 Neurotransmitter Agents Phase 4
16 Adrenergic alpha-Agonists Phase 4
17 Adrenergic Agonists Phase 4
18 Adrenergic Agents Phase 4
19
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3 3680
20
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 3003 5743
21
Prednisone Approved, Vet_approved 53-03-2 5865
22
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
23
Clotrimazole Approved, Vet_approved 23593-75-1 2812
24
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
25
Lidocaine Approved, Vet_approved 137-58-6 3676
26
Prilocaine Approved 721-50-6 4906
27
Lamotrigine Approved, Investigational 84057-84-1 3878
28
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
29
Gabapentin Approved, Investigational 60142-96-3 3446
30
Tannic acid Approved 1401-55-4 16129878 16129778
31 Antiemetics
32 Gastrointestinal Agents
33 Anti-Infective Agents
34 Keratolytic Agents
35 Antifungal Agents
36 Dermatologic Agents
37 Insulin, Globin Zinc
38
Insulin
39 Pharmaceutical Solutions
40 Antipsychotic Agents
41 Sodium Channel Blockers
42 Psychotropic Drugs
43 Calcium, Dietary
44 Anticonvulsants
45 calcium channel blockers
46 Diuretics, Potassium Sparing
47
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
2 Efficacy of Topical Apraclonidine for the Treatment of Ocular Synkinesis Not yet recruiting NCT05167760 Phase 4 Apraclonidine
3 Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla. Unknown status NCT03496025 Phase 1
4 Imaging of Facial Neuritis Using T2-weighted Gradient-echo Fast Imaging Employing Steady State Acquisition After Gadolinium Injection Unknown status NCT03543384
5 Intratympanic Stereoidal Injections for Facial Nerve Palsy Unknown status NCT03371589 Dexamethasone
6 Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China Unknown status NCT01201642 Prednisolone
7 Neuro Occlusal Rehabilitation in Patient With Peripheral Facial Paralysis - a Randomized Clinical Trial Completed NCT01327157
8 The Role of Collagen in the Rehabilitation of Peripheral Paralysis of the Facial Nerve Completed NCT04353908
9 The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery Completed NCT02489162
10 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Lamotrigine;Placebo (for Lamotrigine)
11 Electro Physiological Responses to Kabat Motor Control Re-education on Bell's Palsy: A Randomized Controlled Study Completed NCT04894513
12 Blink Restoration in Patients With Facial Nerve Palsy Recruiting NCT05504473

Search NIH Clinical Center for Facial Nerve Disease

Genetic Tests for Facial Nerve Disease

Genetic tests related to Facial Nerve Disease:

# Genetic test Affiliating Genes
1 Facial Nerve Disorder 28

Anatomical Context for Facial Nerve Disease

Organs/tissues related to Facial Nerve Disease:

MalaCards : Eye, Bone

Publications for Facial Nerve Disease

Articles related to Facial Nerve Disease:

(show all 24)
# Title Authors PMID Year
1
Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in Bell's palsy. 62
32972214 2021
2
Peripheral facial paralysis as presenting symptom of COVID-19 in a pregnant woman. 62
32784234 2020
3
Definitive re-irradiation using intensity-modulated radiation therapy in cancers of the head and neck, focusing on rare tumors. 62
29468910 2018
4
Long-term follow-up after stereotactic radiosurgery of intracanalicular acoustic neurinoma. 62
28427410 2017
5
[Neurosonography of the facial nerve in children with idiopathic neuropathy of facial nerve]. 62
29376984 2017
6
Cognitive Flexibility in Primary Dystonia. 62
27333537 2016
7
Weighting of Facial Grading Variables to Disfigurement in Facial Palsy. 62
27124886 2016
8
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. 62
26889221 2016
9
Intra-operative monitoring of two facial muscles in hemifacial spasm surgery. 62
26073921 2015
10
Idiopathic oculostapedial synkinesis without history of facial nerve palsy. 62
24892367 2015
11
The minimally invasive, orbicularis-sparing, lower eyelid recession for mild to moderate lower eyelid retraction with reduced orbicularis strength. 62
24434916 2014
12
Clinical features and treatment status of hemifacial spasm in China. 62
24571874 2014
13
Supramaximal stimulation during intraoperative facial nerve monitoring as a simple parameter to predict early functional outcome after parotidectomy. 62
23448353 2013
14
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. 62
23682941 2013
15
Idiopathic tinnitus concomitant with eye closure. 62
22215457 2012
16
Pediatric otogenic intracranial abscesses. 62
20172394 2010
17
Recurrent Bell's palsy in a young woman. 62
18946598 2008
18
Annualized incidence and spectrum of illness from an outbreak investigation of Bell's palsy. 62
12207155 2002
19
Prognostic value of electromyography in acute peripheral facial nerve palsy. 62
11314702 2001
20
Metastatic carcinoma of the temporal bone. 62
8892576 1996
21
Crossed R1 response of the blink reflex in peripheral facial palsy. 62
7781575 1995
22
3D-FT MRI of the facial nerve. 62
7991093 1994
23
MR imaging of the intratemporal facial nerve by using surface coils. 62
3492891 1987
24
[Significance of the intermediate nerve for topical diagnosis of the facial nerve disease]. 62
13620136 1958

Variations for Facial Nerve Disease

Expression for Facial Nerve Disease

Search GEO for disease gene expression data for Facial Nerve Disease.

Pathways for Facial Nerve Disease

Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 TNF CD8A CD4
2 11.2 TNF CD8A CD4
3 10.98 TNF CRP CD82
4
Show member pathways
10.81 CRP CD8A CD4 ACE2

GO Terms for Facial Nerve Disease

Cellular components related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.4 TNF MOG CD8A CD4 AQP4 ACE

Biological processes related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.26 ACE2 ACE
2 negative regulation of signaling receptor activity GO:2000272 9.1 TNF MTRNR2L5 MTRNR2L4 ACE2

Molecular functions related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-dipeptidase activity GO:0008241 8.92 ACE2 ACE

Sources for Facial Nerve Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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