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MCID: FCL011
MIFTS: 32

Facial Nerve Disease

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Facial Nerve Disease

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MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 12 15 17
Facial Nerve Diseases 72

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1756
ICD9CM 35 351 351.9
MeSH 44 D005155
NCIt 50 C27594
SNOMED-CT 68 90039006
ICD10 33 G51 G51.8 G51.9
UMLS 72 C0015464
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Summaries for Facial Nerve Disease

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MalaCards based summary : Facial Nerve Disease, also known as facial nerve diseases, is related to geniculate ganglionitis and moebius syndrome, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is LIPN (Lipase Family Member N), and among its related pathways/superpathways is N-cadherin signaling events. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include bone, tongue and pons, and related phenotype is cellular.

Wikipedia : 75 The facial nerve is the seventh cranial nerve, or simply CN VII. It emerges from the pons of the... more...

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Related Diseases for Facial Nerve Disease

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Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 geniculate ganglionitis 11.4
2 moebius syndrome 11.0
3 bell's palsy 10.4 LIPN HOXB1
4 trigeminal nerve disease 10.3 MT-TC LIPN
5 meningioma, radiation-induced 10.1 NF2 CADM1
6 fibrosis of extraocular muscles, congenital, 2 10.0 PHOX2A KIF21A
7 exotropia 9.9 PHOX2A KIF21A
8 hypotropia 9.9 PHOX2A KIF21A
9 neurofibromatosis, type ii 9.9 NF2 CADM1
10 ametropic amblyopia 9.9 MTRNR2L5 CADM1
11 ocular motility disease 9.8 PHOX2A KIF21A
12 tukel syndrome 9.8 PHOX2A KIF21A HOXB1
13 strabismus 9.8 PHOX2A KIF21A HOXB1
14 asthenopia 9.7 MTRNR2L5 LIPN CADM1
15 premenstrual tension 9.6 MTRNR2L5 LRP5 LIPN
16 cranial nerve disease 9.3 PHOX2A MARVELD1 LIPN KIF21A
17 paralytic squint 9.0 PHOX2A MTRNR2L5 KIF21A CADM1
18 facial paralysis 8.7 NF2 MARVELD1 LRP5 LIPN HOXB1 GSN

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease
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Symptoms & Phenotypes for Facial Nerve Disease

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UMLS symptoms related to Facial Nerve Disease:


oral manifestations, facial paresis, numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.23 ANTXR2 CADM1 CD40LG CD82 GSN HOXB1
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Drugs & Therapeutics for Facial Nerve Disease

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Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
6
Cortisone Experimental Phase 4 53-06-5 222786
7 Neuroprotective Agents Phase 4
8 Methylprednisolone Acetate Phase 4
9 Protective Agents Phase 4
10 Prednisolone acetate Phase 4
11
Prednisone Approved, Vet_approved 53-03-2 5865
12
tannic acid Approved 1401-55-4
13
Gabapentin Approved, Investigational 60142-96-3 3446
14
Lamotrigine Approved, Investigational 84057-84-1 3878
15
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
16
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
17
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
18
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
19
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
20
Calcium Approved, Nutraceutical 7440-70-2 271
21 Central Nervous System Depressants
22 Psychotropic Drugs
23 Sodium Channel Blockers
24 Diuretics, Potassium Sparing
25 Tranquilizing Agents
26 calcium channel blockers
27 Anticonvulsants
28 Antipsychotic Agents
29 Calcium, Dietary
30 Antifungal Agents
31 Keratolytic Agents
32 Dermatologic Agents
33 Anti-Infective Agents
34 Hormones
35 Anti-Inflammatory Agents
36 Gastrointestinal Agents
37 Antiemetics
38 glucocorticoids
39 Peripheral Nervous System Agents
40 Antineoplastic Agents, Hormonal
41 Hormone Antagonists
42 Hormones, Hormone Substitutes, and Hormone Antagonists
43 Autonomic Agents
44 Pharmaceutical Solutions
45 BB 1101

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
2 Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China Unknown status NCT01201642 Prednisolone
3 The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery Completed NCT02489162
4 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Lamotrigine;Placebo (for Lamotrigine)
5 Neuro Occlusal Rehabilitation in Patient With Peripheral Facial Paralysis - a Randomized Clinical Trial Completed NCT01327157
6 Imaging of Facial Neuritis Using T2-weighted Gradient-echo Fast Imaging Employing Steady State Acquisition After Gadolinium Injection Recruiting NCT03543384
7 Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla. Enrolling by invitation NCT03496025
8 Intratympanic Stereoidal Injections for Facial Nerve Palsy Not yet recruiting NCT03371589 Dexamethasone

Search NIH Clinical Center for Facial Nerve Disease

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Genetic Tests for Facial Nerve Disease

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Anatomical Context for Facial Nerve Disease

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MalaCards organs/tissues related to Facial Nerve Disease:

41
Bone, Tongue, Pons, Eye
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Publications for Facial Nerve Disease

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Articles related to Facial Nerve Disease:

(show all 17)
# Title Authors PMID Year
1
[The progress of glucocorticoids via postauricular injection in treatment of sudden hearing loss]. 38
29871146 2016
2
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. 38
26889221 2016
3
Reference values for dynamic facial muscle ultrasonography in adults. 38
24519557 2014
4
The minimally invasive, orbicularis-sparing, lower eyelid recession for mild to moderate lower eyelid retraction with reduced orbicularis strength. 38
24434916 2014
5
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. 38
23682941 2013
6
Idiopathic tinnitus concomitant with eye closure. 38
22215457 2012
7
[Anomaly of infrared thermal radiation intensity on unilateral mild to moderate Bell's palsy]. 38
21800579 2011
8
Features of facial asymmetry following incomplete recovery from facial paralysis. 38
20879064 2010
9
[Electrophysiological examination of the cranial nerves: technical aspects and practical applications]. 38
15244162 2004
10
Cortical representation of the orbicularis oculi muscle as assessed by transcranial magnetic stimulation (TMS). 38
11801987 2001
11
[The normal value and clinical applications of the blink reflex]. 38
11938846 1998
12
Crossed R1 response of the blink reflex in peripheral facial palsy. 38
7781575 1995
13
3D-FT MRI of the facial nerve. 38
7991093 1994
14
[Intratemporal course of the facial nerve in magnetic resonance imaging]. 38
2917878 1989
15
MR imaging of the intratemporal facial nerve by using surface coils. 38
3492891 1987
16
Neuromyography in the diagnostics of Bell's palsy. 38
6475422 1984
17
[Significance of the intermediate nerve for topical diagnosis of the facial nerve disease]. 38
13620136 1958
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Variations for Facial Nerve Disease

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Expression for Facial Nerve Disease

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Search GEO for disease gene expression data for Facial Nerve Disease.
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Pathways for Facial Nerve Disease

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Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
N-cadherin signaling events 1
10.14 LRP5 GSN
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GO Terms for Facial Nerve Disease

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Cellular components related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.61 NF2 MARVELD1 LRP5 KIF21A GSN CD82
2 cortical actin cytoskeleton GO:0030864 8.62 NF2 GSN

Biological processes related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 toxin transport GO:1901998 8.62 LRP5 ANTXR2
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Sources for Facial Nerve Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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