Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: FCL011
MIFTS: 35

Facial Nerve Disease

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Facial Nerve Disease

About this section

MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 12 15 17
Facial Nerve Diseases 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1756
ICD9CM 34 351
MeSH 43 D005155
NCIt 49 C27594
SNOMED-CT 67 422426003
ICD10 32 G51 G51.8 G51.9
UMLS 71 C0015464
Sources

Summaries for Facial Nerve Disease

About this section
MalaCards based summary : Facial Nerve Disease, also known as facial nerve diseases, is related to geniculate ganglionitis and moebius syndrome, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is MARVELD1 (MARVEL Domain Containing 1), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Primary immunodeficiency. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, pons and tongue, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 74 The facial nerve is the seventh cranial nerve, or simply CN VII. It emerges from the pons of the... more...

Sources

Related Diseases for Facial Nerve Disease

About this section

Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 388)
# Related Disease Score Top Affiliating Genes
1 geniculate ganglionitis 11.4
2 moebius syndrome 11.0
3 histoplasmosis meningitis 10.6 CD40LG ACE
4 american histoplasmosis 10.6 CD40LG CD4
5 syphilitic meningitis 10.6 CD40LG CD4
6 brawny scleritis 10.6 CD40LG ACE
7 japanese spotted fever 10.5 CRP CD40LG
8 ametropic amblyopia 10.5 MTRNR2L5 MTRNR2L4
9 asymptomatic neurosyphilis 10.5 CD40LG CD4
10 premenstrual tension 10.5 MTRNR2L5 LIPN
11 chronic orbital inflammation 10.5 CRP CD40LG
12 fournier gangrene 10.5 CD40LG ALB
13 latent syphilis 10.5 CD40LG CD4
14 gastroduodenitis 10.5 CD40LG CD4
15 heterophyiasis 10.5 CD40LG ALB
16 mediastinum teratoma 10.5 CRP ACE
17 primary syphilis 10.5 CD40LG CD4
18 transient arthritis 10.5 CD40LG CD4
19 necrotizing ulcerative gingivitis 10.5 CD40LG CD4
20 acute dacryoadenitis 10.5 CRP ACE
21 facial hemiatrophy 10.5 KANTR CRP
22 rheumatoid arthritis interstitial lung disease 10.5 CRP CD4
23 cardiac tuberculosis 10.5 CRP ACE
24 tertiary neurosyphilis 10.5 CD40LG CD4
25 chronic duodenal ileus 10.5 CRP ALB
26 pericardial tuberculosis 10.5 CRP CD4
27 non-secretory myeloma 10.5 CD40LG ALB
28 mononeuritis multiplex 10.5 CRP CD40LG CD4
29 ocular tuberculosis 10.5 CD4 ACE
30 cerebellopontine angle tumor 10.5 NF2 KANTR
31 glossopharyngeal nerve disease 10.5 NF2 KANTR CRP
32 opportunistic bacterial infectious disease 10.5 CRP CD40LG CD4
33 mikulicz disease 10.5 CRP CD40LG CD4
34 suprasellar meningioma 10.5 NT5C3A NF2
35 aortitis 10.5 CRP CD40LG CD4
36 bartonellosis 10.5 CRP CD40LG CD4
37 mastoiditis 10.5 CRP CD40LG CD4
38 cervical adenitis 10.5 CRP CD40LG CD4
39 chlamydia pneumonia 10.5 CRP CD40LG CD4
40 posterior scleritis 10.5 CRP ACE
41 polyclonal hypergammaglobulinemia 10.5 CRP CD40LG CD4
42 salpingitis 10.5 CRP CD40LG CD4
43 epididymis disease 10.5 CRP CD40LG CD4
44 ecthyma 10.5 CRP CD40LG
45 vaginal discharge 10.5 CRP CD40LG CD4
46 bacillary angiomatosis 10.5 CD40LG CD4
47 urethritis 10.5 CRP CD40LG CD4
48 neurilemmoma of the fifth cranial nerve 10.5 NT5C3A NF2
49 ventilation pneumonitis 10.5 CD8A CD4
50 trigeminal nerve neoplasm 10.5 NT5C3A NF2

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease
Sources

Symptoms & Phenotypes for Facial Nerve Disease

About this section

UMLS symptoms related to Facial Nerve Disease:


oral manifestations, facial paresis, numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 ALB ANKH CADM1 CD4 CD40LG CD82
2 endocrine/exocrine gland MP:0005379 9.61 ACE ALB CADM1 CD4 CD40LG CD8A
3 immune system MP:0005387 9.36 ACE ALB ANKH CADM1 CD4 CD40LG
Sources

Drugs & Therapeutics for Facial Nerve Disease

About this section

Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Cortisone Experimental Phase 4 53-06-5 222786
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Hormones Phase 4
9 Methylprednisolone Acetate Phase 4
10 Antineoplastic Agents, Hormonal Phase 4
11 glucocorticoids Phase 4
12 Hormone Antagonists Phase 4
13 Anti-Inflammatory Agents Phase 4
14
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
15
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
16
Prednisone Approved, Vet_approved 53-03-2 5865
17
Lamotrigine Approved, Investigational 84057-84-1 3878
18
Gabapentin Approved, Investigational 60142-96-3 3446
19
tannic acid Approved 1401-55-4
20
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
21
Lidocaine Approved, Vet_approved 137-58-6 3676
22
Prilocaine Approved 721-50-6 4906
23
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
24
Clotrimazole Approved, Vet_approved 23593-75-1 2812
25
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
26 Antiemetics
27 Gastrointestinal Agents
28 Sodium Channel Blockers
29 Psychotropic Drugs
30 Diuretics, Potassium Sparing
31 Anticonvulsants
32 Antipsychotic Agents
33 Calcium, Dietary
34 calcium channel blockers
35 Insulin, Globin Zinc
36 Pharmaceutical Solutions
37 insulin
38 Dermatologic Agents
39 Antifungal Agents
40 Anti-Infective Agents
41 Keratolytic Agents
42
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
2 Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla. Active, not recruiting NCT03496025 Phase 1
3 Imaging of Facial Neuritis Using T2-weighted Gradient-echo Fast Imaging Employing Steady State Acquisition After Gadolinium Injection Unknown status NCT03543384
4 Intratympanic Stereoidal Injections for Facial Nerve Palsy Unknown status NCT03371589 Dexamethasone
5 Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China Unknown status NCT01201642 Prednisolone
6 The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery Completed NCT02489162
7 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Lamotrigine;Placebo (for Lamotrigine)
8 The Role of Collagen in the Rehabilitation of Peripheral Paralysis of the Facial Nerve Completed NCT04353908
9 Neuro Occlusal Rehabilitation in Patient With Peripheral Facial Paralysis - a Randomized Clinical Trial Completed NCT01327157

Search NIH Clinical Center for Facial Nerve Disease

Sources

Genetic Tests for Facial Nerve Disease

About this section
Sources

Anatomical Context for Facial Nerve Disease

About this section

MalaCards organs/tissues related to Facial Nerve Disease:

40
Bone, Pons, Tongue, Eye
Sources

Publications for Facial Nerve Disease

About this section

Articles related to Facial Nerve Disease:

(show all 18)
# Title Authors PMID Year
1
Facial nerve electrodiagnostics for patients with facial palsy: a clinical practice guideline. 61
32270328 2020
2
[The progress of glucocorticoids via postauricular injection in treatment of sudden hearing loss]. 61
29871146 2016
3
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. 61
26889221 2016
4
Reference values for dynamic facial muscle ultrasonography in adults. 61
24519557 2014
5
The minimally invasive, orbicularis-sparing, lower eyelid recession for mild to moderate lower eyelid retraction with reduced orbicularis strength. 61
24434916 2014
6
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. 61
23682941 2013
7
Idiopathic tinnitus concomitant with eye closure. 61
22215457 2012
8
[Anomaly of infrared thermal radiation intensity on unilateral mild to moderate Bell's palsy]. 61
21800579 2011
9
Features of facial asymmetry following incomplete recovery from facial paralysis. 61
20879064 2010
10
[Electrophysiological examination of the cranial nerves: technical aspects and practical applications]. 61
15244162 2004
11
Cortical representation of the orbicularis oculi muscle as assessed by transcranial magnetic stimulation (TMS). 61
11801987 2001
12
[The normal value and clinical applications of the blink reflex]. 61
11938846 1998
13
Crossed R1 response of the blink reflex in peripheral facial palsy. 61
7781575 1995
14
3D-FT MRI of the facial nerve. 61
7991093 1994
15
[Intratemporal course of the facial nerve in magnetic resonance imaging]. 61
2917878 1989
16
MR imaging of the intratemporal facial nerve by using surface coils. 61
3492891 1987
17
Neuromyography in the diagnostics of Bell's palsy. 61
6475422 1984
18
[Significance of the intermediate nerve for topical diagnosis of the facial nerve disease]. 61
13620136 1958
Sources

Variations for Facial Nerve Disease

About this section
Sources

Expression for Facial Nerve Disease

About this section
Search GEO for disease gene expression data for Facial Nerve Disease.
Sources

Pathways for Facial Nerve Disease

About this section

Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell adhesion molecules (CAMs) 36
11.43 CD8A CD40LG CD4 CADM1
2
Primary immunodeficiency 36
10.38 CD8A CD40LG CD4
Sources

GO Terms for Facial Nerve Disease

About this section
Sources

Sources for Facial Nerve Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....