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MCID: FCL011
MIFTS: 25

Facial Nerve Disease

Categories: Neuronal diseases
Genes Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Facial Nerve Disease

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MalaCards integrated aliases for Facial Nerve Disease:

Name: Facial Nerve Disease 12 15
Facial Nerve Diseases 73

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1756
ICD10 33 G51 G51.9
ICD9CM 35 351 351.9
MeSH 44 D005155
NCIt 50 C27594
SNOMED-CT 68 90039006
UMLS 73 C0015464
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Summaries for Facial Nerve Disease

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MalaCards based summary : Facial Nerve Disease, also known as facial nerve diseases, is related to geniculate ganglionitis and bell's palsy, and has symptoms including facial paresis, oral manifestations and numbness along 7th cranial nerve. An important gene associated with Facial Nerve Disease is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways is N-cadherin signaling events. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Related phenotypes are cellular and nervous system

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Related Diseases for Facial Nerve Disease

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Diseases related to Facial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 geniculate ganglionitis 11.3
2 bell's palsy 10.2 HOXB1 LIPN
3 amyloid tumor 10.2 NF2 TUBB3
4 asthenopia 10.2 CADM1 LIPN
5 trigeminal nerve disease 10.1 LIPN MT-TC
6 foramen magnum meningioma 10.1 KANTR NF2
7 meningioma, radiation-induced 10.1 CADM1 NF2
8 trigeminal nerve neoplasm 10.1 KANTR NF2
9 exposure keratitis 10.1 KANTR TUBB3
10 moebius syndrome 10.1 PHOX2A TUBB3
11 congenital ptosis 10.1 KIF21A TUBB3
12 neurilemmoma of the fifth cranial nerve 10.1 KANTR NF2
13 neurofibromatosis, type ii 10.1 CADM1 NF2
14 deafness, autosomal dominant 28 10.1 KIF21A TUBB3
15 anterior cranial fossa meningioma 10.1 KANTR NF2
16 geniculate herpes zoster 10.1 KANTR MT-TC
17 cerebellopontine angle tumor 10.0 KANTR NF2
18 vertebrobasilar insufficiency 10.0 KANTR LRP5
19 premenstrual tension 10.0 KANTR LIPN LRP5
20 fibrosis of extraocular muscles, congenital, 2 10.0 KIF21A PHOX2A
21 endosteal hyperostosis, autosomal dominant 10.0 ANKH LRP5
22 duane retraction syndrome 10.0 KIF21A TUBB3
23 hypertropia 10.0 KANTR KIF21A TUBB3
24 exotropia 9.9 KIF21A PHOX2A TUBB3
25 kearns-sayre syndrome 9.9 KIF21A PHOX2A TUBB3
26 ptosis 9.9 KIF21A PHOX2A TUBB3
27 amblyopia 9.9 PHOX2A TUBB3
28 tukel syndrome 9.8 HOXB1 KIF21A PHOX2A TUBB3
29 strabismus 9.8 HOXB1 KIF21A PHOX2A TUBB3
30 hypotropia 9.7 KANTR KIF21A PHOX2A TUBB3
31 ocular motility disease 9.7 KANTR KIF21A PHOX2A TUBB3
32 peripheral nervous system disease 9.6 KANTR KIF21A MARVELD1 TUBB3
33 paralytic squint 9.6 CADM1 KANTR KIF21A PHOX2A TUBB3
34 cranial nerve disease 9.3 KANTR KIF21A LIPN MARVELD1 PHOX2A TUBB3
35 facial paralysis 9.1 ANKH CADM1 GSN HOXA2 HOXB1 LIPN

Graphical network of the top 20 diseases related to Facial Nerve Disease:



Diseases related to Facial Nerve Disease
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Symptoms & Phenotypes for Facial Nerve Disease

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UMLS symptoms related to Facial Nerve Disease:


facial paresis, oral manifestations, numbness along 7th cranial nerve

MGI Mouse Phenotypes related to Facial Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 ANKH CADM1 GSN HOXA2 HOXB1 LRP5
2 nervous system MP:0003631 9.56 CADM1 GSN HOXA2 HOXB1 LRP5 NF2
3 craniofacial MP:0005382 9.55 ANKH HOXA2 HOXB1 LRP5 NF2
4 respiratory system MP:0005388 9.17 ANKH GSN HOXA2 HOXB1 NF2 PHOX2A
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Drugs & Therapeutics for Facial Nerve Disease

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Drugs for Facial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
3
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
5
Acetylcholine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
6
Acyclovir Approved Phase 4,Not Applicable,Early Phase 1 59277-89-3 2022
7
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 298-46-4 2554
8
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
9
Ondansetron Approved Phase 4 99614-02-5 4595
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
12
Oxcarbazepine Approved Phase 4 28721-07-5 34312
13
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Not Applicable 2920-86-7
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
16 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
17 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
18 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
19 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
21 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
22 Prednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
23 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
26 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
27 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 incobotulinumtoxinA Phase 4,Phase 2
30 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 onabotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
33 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
34 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Botulinum Toxins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 valacyclovir Phase 4,Not Applicable
39 Antiviral Agents Phase 4,Not Applicable,Early Phase 1
40 Anti-Infective Agents Phase 4,Not Applicable,Early Phase 1
41 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
42 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
43 Dermatologic Agents Phase 4,Not Applicable
44 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
45 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Not Applicable
46 Analgesics, Opioid Phase 4
47 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
48 Excitatory Amino Acids Phase 4,Phase 2,Phase 3,Not Applicable
49 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
50 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
2 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
4 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
5 Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy Not yet recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
6 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
9 Intratympanic Steroid for Bell's Palsy Recruiting NCT03508440 Phase 2, Phase 3 Prednisone
10 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
11 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
12 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
13 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
14 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
15 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
16 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
17 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
18 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
19 Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children Completed NCT01777633 Phase 1, Phase 2
20 The Effect of Human Adipose Tissue-derived MSCs in Romberg's Disease Completed NCT01309061 Phase 2
21 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
22 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
23 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
24 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
25 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
26 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
27 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
28 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
29 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
30 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
31 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Not Applicable Prednisolone
32 Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm Unknown status NCT02853942 Early Phase 1 Mecobalamin
33 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
34 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
35 Role of Mesenchymal Stem Cells in Fat Grafting Unknown status NCT02494752 Not Applicable
36 Treatment of Chronic Myofascial Pain Syndrome Over Neck by Using Intravascular Laser Irradiation of Blood Unknown status NCT02470000 Not Applicable
37 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598 Not Applicable
38 The Effect of Low Level Laser Therapy (LLLT) in Myofacial Pain Syndrome Unknown status NCT01417637 Not Applicable
39 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
40 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
41 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
42 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Not Applicable Lamotrigine;Placebo (for Lamotrigine)
43 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157 Not Applicable
44 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
45 MDs on Botox Utility (MOBILITY) Completed NCT00535938
46 A Randomized Trial of Induction Versus Expectant Management Completed NCT01990612 Not Applicable
47 Impairments of Oral Language in Mobius Syndrome Completed NCT00856531
48 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
49 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
50 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable

Search NIH Clinical Center for Facial Nerve Disease

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Genetic Tests for Facial Nerve Disease

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Anatomical Context for Facial Nerve Disease

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Publications for Facial Nerve Disease

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Articles related to Facial Nerve Disease:

# Title Authors Year
1
Understanding the features of posterior auricular muscle response in a facial nerve disease prototype. ( 23682941 )
2013
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Variations for Facial Nerve Disease

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Expression for Facial Nerve Disease

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Search GEO for disease gene expression data for Facial Nerve Disease.
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Pathways for Facial Nerve Disease

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Pathways related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
N-cadherin signaling events 1
10.14 GSN LRP5
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GO Terms for Facial Nerve Disease

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Cellular components related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cortical actin cytoskeleton GO:0030864 8.62 GSN NF2

Biological processes related to Facial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryonic skeletal system morphogenesis GO:0048704 9.26 HOXA2 HOXB1
2 negative regulation of osteoblast differentiation GO:0045668 9.16 HOXA2 LRP5
3 osteoblast development GO:0002076 8.96 HOXA2 LRP5
4 anterior/posterior pattern specification GO:0009952 8.8 HOXA2 HOXB1 LRP5
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Sources for Facial Nerve Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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