MCID: FLL023
MIFTS: 36

Fallopian Tube Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fallopian Tube Adenocarcinoma

MalaCards integrated aliases for Fallopian Tube Adenocarcinoma:

Name: Fallopian Tube Adenocarcinoma 12 15 73
Adenocarcinoma of the Fallopian Tube 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3706
NCIt 50 C6265
UMLS 73 C1333590

Summaries for Fallopian Tube Adenocarcinoma

Disease Ontology : 12 A fallopian tube carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Fallopian Tube Adenocarcinoma, also known as adenocarcinoma of the fallopian tube, is related to fallopian tube endometrioid adenocarcinoma and fallopian tube mucinous adenocarcinoma. An important gene associated with Fallopian Tube Adenocarcinoma is MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1). The drugs Bevacizumab and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and ovary, and related phenotypes are Synthetic lethal with cisplatin and endocrine/exocrine gland

Related Diseases for Fallopian Tube Adenocarcinoma

Diseases related to Fallopian Tube Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 fallopian tube endometrioid adenocarcinoma 30.8 CALB2 ERBB2 INSM1 MME MYOG PTPRN
2 fallopian tube mucinous adenocarcinoma 11.3
3 fallopian tube clear cell adenocarcinoma 11.3
4 fallopian tube papillary adenocarcinoma 11.3
5 fallopian tube serous adenocarcinoma 11.3
6 adenocarcinoma 10.7
7 cerebellar degeneration 10.3
8 paraneoplastic cerebellar degeneration 10.3
9 vulval paget's disease 10.2 ERBB2 PTCRA
10 breast medullary carcinoma 10.2 BRCA1 ERBB2
11 vulva adenocarcinoma 10.2 ERBB2 PTCRA
12 uterine corpus serous adenocarcinoma 10.2 BRCA1 ERBB2
13 hereditary site-specific ovarian cancer syndrome 10.2 BRCA1 BRCA2
14 cervical carcinosarcoma 10.2 MAPK8IP1 MME
15 breast reconstruction 10.2 BRCA1 BRCA2
16 nosophobia 10.2 BRCA1 BRCA2
17 cancerophobia 10.2 BRCA1 BRCA2
18 breast-ovarian cancer, familial 1 10.2 BRCA1 BRCA2
19 lobular neoplasia 10.2 BRCA1 ERBB2
20 synchronous bilateral breast carcinoma 10.2 BRCA1 BRCA2
21 papillary adenocarcinoma 10.2
22 clear cell adenocarcinoma 10.2
23 glycogen-rich clear cell breast carcinoma 10.2 BRCA1 BRCA2
24 premature menopause 10.2 BRCA1 BRCA2
25 uterine corpus cancer 10.2 BRCA1 ERBB2
26 peritoneum cancer 10.2 BRCA1 BRCA2
27 sarcomatoid squamous cell skin carcinoma 10.1 MAPK8IP1 MME
28 breast benign neoplasm 10.1 ERBB2 MME
29 thoracic benign neoplasm 10.1 ERBB2 MME
30 adenofibroma 10.1 CALB2 MME
31 neurogenic bowel 10.1 CALB2 PTCRA
32 cervix endometriosis 10.1 CALB2 MME
33 mixed cell type cancer 10.1 ERBB2 MME
34 malignant leydig cell tumor 10.1 CALB2 MME
35 rete testis adenocarcinoma 10.1 CALB2 MME
36 lynch syndrome i 10.1 BRCA1 BRCA2
37 functional colonic disease 10.1 CALB2 PTCRA
38 mutagen sensitivity 10.1 BRCA1 BRCA2
39 fallopian tube disease 10.1 BRCA1 BRCA2 MAPK8IP1
40 spermatocele 10.1 CALB2 MME
41 clear cell adenofibroma 10.1 BRCA2 CALB2
42 rete testis neoplasm 10.1 CALB2 MME
43 fanconi anemia, complementation group q 10.1 BRCA1 BRCA2
44 lung combined type small cell carcinoma 10.1 MME MYOG
45 tuberculous salpingitis 10.1 BRCA1 BRCA2 ERBB2
46 bilateral breast cancer 10.1 BRCA1 BRCA2 ERBB2
47 primary peritoneal carcinoma 10.1 BRCA1 BRCA2 ERBB2
48 fallopian tube carcinoma 10.1 BRCA1 BRCA2 ERBB2
49 breast carcinoma in situ 10.1 BRCA1 BRCA2 ERBB2
50 ovarian cancer 1 10.1 BRCA1 BRCA2 ERBB2

Graphical network of the top 20 diseases related to Fallopian Tube Adenocarcinoma:



Diseases related to Fallopian Tube Adenocarcinoma

Symptoms & Phenotypes for Fallopian Tube Adenocarcinoma

GenomeRNAi Phenotypes related to Fallopian Tube Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA1 BRCA2

MGI Mouse Phenotypes related to Fallopian Tube Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 BRCA1 BRCA2 ERBB2 INSM1 MAPK8IP1 PTCRA
2 homeostasis/metabolism MP:0005376 9.28 ATP5IF1 BRCA1 BRCA2 ERBB2 INSM1 MAPK8IP1

Drugs & Therapeutics for Fallopian Tube Adenocarcinoma

Drugs for Fallopian Tube Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
2
Gemcitabine Approved Phase 3 95058-81-4 60750
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Carboplatin Approved Phase 3,Phase 1,Phase 2 41575-94-4 10339178 38904 498142
5
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2 33069-62-4 36314
6
Atezolizumab Approved, Investigational Phase 3 1380723-44-3
7
Doxil Approved June 1999 Phase 3 31703
8 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
9 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
10 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2
11 Immunologic Factors Phase 3,Phase 1,Phase 2
12 Topoisomerase Inhibitors Phase 3
13 Anti-Bacterial Agents Phase 3
14 Immunoglobulins Phase 3,Phase 1,Phase 2
15 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
16 Antibiotics, Antitubercular Phase 3
17 Antibodies Phase 3,Phase 1,Phase 2
18
Nivolumab Approved Phase 2 946414-94-4
19
Tremelimumab Investigational Phase 1, Phase 2 745013-59-6
20 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
21 Antimitotic Agents Phase 2,Phase 1
22
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
23 Endothelial Growth Factors Phase 1
24 Immunoglobulin G Phase 1
25 Mitogens Phase 1
26 CHI3L1 protein, human

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 ATALANTE: Atezolizumab vs Placebo Phase III Study in Late Relapse Ovarian Cancer Treated With Chemotherapy+Bevacizumab Recruiting NCT02891824 Phase 3 atezolizumab + avastin + platinum-based chemotherapy;placebo + avastin + platinum-based chemotherapy
2 Immunotherapy With Neo-adjuvant Chemotherapy for OVarian Cancer Recruiting NCT03249142 Phase 1, Phase 2 ARM A Durvalumab/chemotherapy association;ARM B Durvalumab/Tremelimumab/chemotherapy association
3 Paclitaxel and Bevacizumab With or Without Emactuzumab in Treating Patients With Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02923739 Phase 2 Paclitaxel
4 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
5 Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or Fallopian Tube Cancer Terminated NCT01137071 Phase 2
6 Dose Escalation of Cisplatin Hyperthermic Intraperitoneal Chemotherapy After Surgery in Patients With Unresectable Stage IIIC Ovarian, Tube or Peritoneal Primary Adenocarcinoma Completed NCT02217956 Phase 1 Cisplatin;Bevacizumab
7 Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma Recruiting NCT03608618 Phase 1
8 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
9 The Effects of Moderate Exercise on Distress, Quality of Life, and Biomarkers of Angiogenesis and Chronic Stress in Ovarian Cancer Survivors Recruiting NCT03641287 Not Applicable
10 Compare Fallopian Tube Cells Collected by MAKO 7 With Removed Ovarian/Tubal Tissue to Determine Presence of Malignant or Benign Cells Recruiting NCT03593681
11 YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy Terminated NCT00899093

Search NIH Clinical Center for Fallopian Tube Adenocarcinoma

Genetic Tests for Fallopian Tube Adenocarcinoma

Anatomical Context for Fallopian Tube Adenocarcinoma

MalaCards organs/tissues related to Fallopian Tube Adenocarcinoma:

41
Lung, Breast, Ovary, Cervix, Bone, Colon, Testis

Publications for Fallopian Tube Adenocarcinoma

Articles related to Fallopian Tube Adenocarcinoma:

(show top 50) (show all 56)
# Title Authors Year
1
A Preliminary Report Requiring Continuation of Research to Confirm Fallopian Tube Adenocarcinoma: A Non-Experimental, Non-Randomized, Cross-Sectional Study. ( 30059956 )
2018
2
Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review. ( 28386581 )
2017
3
Primary Adenocarcinoma of the Fallopian Tube: A Rare Entity. ( 29207787 )
2017
4
Long-term disease-free survival in a patient with cerebral recurrence from adenocarcinoma of the fallopian tube. ( 23815803 )
2013
5
Primary adenocarcinoma of the fallopian tube presenting as hydrosalpinx. ( 21627441 )
2011
6
Challenging diagnosis: florid epithelial hyperplasia versus adenocarcinoma of the fallopian tube. ( 20025495 )
2010
7
Primary fallopian tube adenocarcinoma with brain and lung metastasis. ( 19805996 )
2009
8
Synchronous granulosa cell tumour of the ovary and fallopian tube adenocarcinoma: two rare gynaecological malignancies. ( 17116067 )
2006
9
Sister Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarcinoma. ( 16698532 )
2006
10
Paraneoplastic cerebellar degeneration with fallopian tube adenocarcinoma. ( 16126258 )
2005
11
Primary fallopian tube adenocarcinoma: preoperative diagnosis, treatment and follow-up. ( 15493187 )
2004
12
Superior vena cava syndrome during chemotherapy for stage 3c fallopian tube adenocarcinoma. ( 15047247 )
2004
13
Cerebral metastasis from a primary adenocarcinoma of the fallopian tube. ( 15385143 )
2004
14
Primary adenocarcinoma of the fallopian tube: a case report. ( 15597861 )
2004
15
Paraneoplastic cerebellar degeneration heralding fallopian tube adenocarcinoma. ( 11328418 )
2001
16
Outcome of advanced primary fallopian tube adenocarcinoma. ( 10575806 )
1999
17
Surgico-pathological stage I primary fallopian tube adenocarcinoma. ( 9849719 )
1998
18
Prognosis of primary fallopian tube adenocarcinoma: report of 25 patients. ( 10215444 )
1998
19
Splenic metastasis of a fallopian tube adenocarcinoma. ( 9830550 )
1998
20
Adenocarcinoma of the fallopian tube: results of a multi-institutional retrospective analysis of 72 patients. ( 9422560 )
1998
21
Early invasive adenocarcinoma of the fallopian tube: a case report and review of the literature. ( 9564102 )
1998
22
Adenocarcinoma of the fallopian tube. Natural history of an isolated splenic metastasis. ( 9140442 )
1997
23
p53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma. ( 8883398 )
1996
24
Recurrent adenocarcinoma of the fallopian tube presenting as leptomeningeal carcinomatosis. ( 8852420 )
1996
25
Port-site metastases of adenocarcinoma of the fallopian tube after laparoscopically assisted vaginal hysterectomy and salpingo-oophorectomy. ( 8881063 )
1996
26
Primary fallopian tube adenocarcinoma: clinical complete response after salvage treatment with high-dose paclitaxel. ( 7622116 )
1995
27
Primary fallopian tube adenocarcinoma in situ associated with adjuvant tamoxifen therapy for breast carcinoma. ( 8157199 )
1994
28
Primary fallopian tube adenocarcinoma with metastasis to the uterine cervix. A case report. ( 8181486 )
1993
29
Primary invasive adenocarcinoma of the fallopian tube diagnosed by histological examination of a surgical sterilization specimen. Case report. ( 8181485 )
1993
30
Primary adenocarcinoma of the fallopian tube. Review of the literature. ( 11578324 )
1993
31
Combination chemotherapy in advanced adenocarcinoma of the fallopian tube. ( 2013452 )
1991
32
Primary adenocarcinoma of the fallopian tube--a case report. ( 2520049 )
1989
33
Primary adenocarcinoma of the fallopian tube. ( 2673790 )
1989
34
Primary adenocarcinoma of the fallopian tube with tuberculosis (short communication). ( 2806317 )
1989
35
Primary fallopian tube adenocarcinoma presenting as a hydrosalpinx: CT appearance. ( 3392277 )
1988
36
Fallopian tube adenocarcinoma: common extraperitoneal recurrence. ( 3710267 )
1986
37
Primary adenocarcinoma of the fallopian tube. ( 3780765 )
1986
38
Mandibular metastasis from a primary adenocarcinoma of the fallopian tube. ( 3859619 )
1985
39
A case report of primary adenocarcinoma of the fallopian tube. ( 3970088 )
1985
40
Diagnosis of primary adenocarcinoma of the fallopian tube. ( 4044628 )
1985
41
Adenocarcinoma of the fallopian tube: report of a case with an unusual pattern of metastasis and response to combination chemotherapy. ( 6546733 )
1984
42
Adenocarcinoma of the fallopian tube. ( 6612570 )
1983
43
Obstructing intracolonic metastases secondary to fallopian tube adenocarcinoma. ( 7147990 )
1982
44
Primary adenocarcinoma of the fallopian tube. ( 7095569 )
1982
45
Adenocarcinoma of the Fallopian tube. An ultrastructural study. ( 7157670 )
1982
46
Adenocarcinoma of the fallopian tube. Reexamination of 5 cases observed during the period of 1961-1980 in the Department of Obstetrics and Gynecology, University of Ferrara. ( 7173246 )
1982
47
Primary adenocarcinoma of the fallopian tube. A case report with discussion of its pattern of endometrial spread and possible resulting diagnostic confusion. ( 7215123 )
1981
48
A case of primary adenocarcinoma of the fallopian tube. ( 683046 )
1978
49
Adenocarcinoma of the fallopian tube. Experience with 41 patients. ( 412144 )
1977
50
Advanced adenocarcinoma of the Fallopian tube. ( 4725956 )
1973

Variations for Fallopian Tube Adenocarcinoma

Expression for Fallopian Tube Adenocarcinoma

Search GEO for disease gene expression data for Fallopian Tube Adenocarcinoma.

Pathways for Fallopian Tube Adenocarcinoma

GO Terms for Fallopian Tube Adenocarcinoma

Cellular components related to Fallopian Tube Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.26 CALB2 MAPK8IP1 MME PTPRN
2 lateral element GO:0000800 8.62 BRCA1 BRCA2

Biological processes related to Fallopian Tube Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.56 BRCA1 BRCA2 INSM1 MYOG
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 BRCA1 BRCA2
3 chordate embryonic development GO:0043009 8.96 BRCA1 BRCA2
4 positive regulation of cell cycle arrest GO:0071158 8.8 BRCA1 INSM1 MYOG

Sources for Fallopian Tube Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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