MCID: FLL023
MIFTS: 39

Fallopian Tube Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fallopian Tube Adenocarcinoma

MalaCards integrated aliases for Fallopian Tube Adenocarcinoma:

Name: Fallopian Tube Adenocarcinoma 12 15 73
Adenocarcinoma of the Fallopian Tube 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3706
NCIt 50 C6265
UMLS 73 C1333590

Summaries for Fallopian Tube Adenocarcinoma

Disease Ontology : 12 A fallopian tube carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Fallopian Tube Adenocarcinoma, also known as adenocarcinoma of the fallopian tube, is related to fallopian tube papillary adenocarcinoma and breast medullary carcinoma. An important gene associated with Fallopian Tube Adenocarcinoma is MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1), and among its related pathways/superpathways are Glioma and Gastric cancer. The drugs Bevacizumab and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, cervix and ovary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Fallopian Tube Adenocarcinoma

Diseases related to Fallopian Tube Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 fallopian tube papillary adenocarcinoma 11.6
2 breast medullary carcinoma 10.7 BRCA1 ERBB2
3 vulval paget's disease 10.7 ERBB2 PTCRA
4 hereditary site-specific ovarian cancer syndrome 10.7 BRCA1 BRCA2
5 breast reconstruction 10.7 BRCA1 BRCA2
6 nosophobia 10.7 BRCA1 BRCA2
7 vulva adenocarcinoma 10.7 ERBB2 PTCRA
8 cancerophobia 10.7 BRCA1 BRCA2
9 sarcomatoid squamous cell skin carcinoma 10.7 MAPK8IP1 TP53
10 breast-ovarian cancer, familial 1 10.6 BRCA1 BRCA2
11 non-invasive bladder papillary urothelial neoplasm 10.6 PTCRA TP53
12 bladder papillary transitional cell neoplasm 10.6 PTCRA TP53
13 urinary tract papillary transitional cell benign neoplasm 10.6 PTCRA TP53
14 gallbladder squamous cell carcinoma 10.6 ERBB2 TP53
15 gastric papillary adenocarcinoma 10.6 ERBB2 TP53
16 peritoneum cancer 10.6 BRCA1 BRCA2
17 lobular neoplasia 10.6 BRCA1 ERBB2
18 papillary serous adenocarcinoma 10.6 BRCA1 TP53
19 premature menopause 10.6 BRCA1 BRCA2
20 non-proliferative fibrocystic change of the breast 10.6 ERBB2 TP53
21 pleomorphic adenoma carcinoma 10.6 ERBB2 TP53
22 uterine body mixed cancer 10.6 ERBB2 TP53
23 glioma susceptibility 1 10.6 ERBB2 TP53
24 breast squamous cell carcinoma 10.5 ERBB2 TP53
25 tetraploidy 10.5 BRCA2 TP53
26 adenocarcinoma 10.5
27 oral leukoplakia 10.5 ERBB2 TP53
28 microglandular adenosis 10.5 ERBB2 TP53
29 uterine corpus cancer 10.5 ERBB2 TP53
30 cll/sll 10.5 MME TP53
31 esophagus adenocarcinoma 10.5 ERBB2 TP53
32 cervix endometriosis 10.4 CALB2 MME
33 adenosarcoma 10.4 MME TP53
34 cervix small cell carcinoma 10.4 MAPK8IP1 TP53
35 malignant leydig cell tumor 10.4 CALB2 MME
36 adenofibroma 10.4 CALB2 MME
37 clear cell cystadenofibroma 10.4 CALB2 TP53
38 neurogenic bowel 10.4 CALB2 PTCRA
39 ovary adenocarcinoma 10.4 ERBB2 TP53
40 rete testis adenocarcinoma 10.4 CALB2 MME
41 myxosarcoma 10.4 BRCA1 TP53
42 tuberculous salpingitis 10.4 BRCA1 BRCA2 ERBB2
43 lynch syndrome i 10.3 BRCA1 BRCA2
44 lung combined type small cell carcinoma 10.3 MME MYOG
45 bilateral breast cancer 10.3 BRCA1 BRCA2 ERBB2
46 cervical carcinosarcoma 10.3 MAPK8IP1 MME TP53
47 functional colonic disease 10.3 CALB2 PTCRA
48 rete testis neoplasm 10.3 CALB2 MME
49 in situ carcinoma 10.3 BRCA1 ERBB2 TP53
50 spermatocele 10.3 CALB2 MME

Graphical network of the top 20 diseases related to Fallopian Tube Adenocarcinoma:



Diseases related to Fallopian Tube Adenocarcinoma

Symptoms & Phenotypes for Fallopian Tube Adenocarcinoma

MGI Mouse Phenotypes related to Fallopian Tube Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 PTCRA PTPRN TP53 BRCA1 BRCA2 ERBB2
2 homeostasis/metabolism MP:0005376 9.65 MAPK8IP1 MME MYOG PTPRN TP53 ATP5IF1
3 integument MP:0010771 9.1 MME MYOG TP53 BRCA1 BRCA2 ERBB2

Drugs & Therapeutics for Fallopian Tube Adenocarcinoma

Drugs for Fallopian Tube Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 1 216974-75-3
2
Carboplatin Approved Phase 3,Phase 1,Phase 2 41575-94-4 10339178 498142 38904
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Gemcitabine Approved Phase 3 95058-81-4 60750
5
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2 33069-62-4 36314
6
Doxil Approved June 1999 Phase 3 31703
7 Angiogenesis Inhibitors Phase 3,Phase 1
8 Angiogenesis Modulating Agents Phase 3,Phase 1
9 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2
10 Anti-Bacterial Agents Phase 3
11 Antibiotics, Antitubercular Phase 3
12 Antibodies Phase 3,Phase 1,Phase 2
13 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
14 Immunoglobulins Phase 3,Phase 1,Phase 2
15 Topoisomerase Inhibitors Phase 3
16
nivolumab Approved Phase 2 946414-94-4
17
Tremelimumab Investigational Phase 1, Phase 2 745013-59-6
18
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
19 Antimitotic Agents Phase 1
20 Antineoplastic Agents, Phytogenic Phase 1
21 Endothelial Growth Factors Phase 1
22 Immunoglobulin G Phase 1
23 Mitogens Phase 1
24 CHI3L1 protein, human

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ATALANTE: Atezolizumab vs Placebo Phase III Study in Late Relapse Ovarian Cancer Treated With Chemotherapy+Bevacizumab Recruiting NCT02891824 Phase 3 atezolizumab + avastin + platinum-based chemotherapy;placebo + avastin + platinum-based chemotherapy
2 Immunotherapy With Neo-adjuvant Chemotherapy for OVarian Cancer Recruiting NCT03249142 Phase 1, Phase 2 ARM A Durvalumab/chemotherapy association;ARM B Durvalumab/Tremelimumab/chemotherapy association
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
4 Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or Fallopian Tube Cancer Terminated NCT01137071 Phase 2
5 Dose Escalation of Cisplatin Hyperthermic Intraperitoneal Chemotherapy After Surgery in Patients With Unresectable Stage IIIC Ovarian, Tube or Peritoneal Primary Adenocarcinoma Completed NCT02217956 Phase 1 Cisplatin;Bevacizumab
6 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
7 YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy Terminated NCT00899093

Search NIH Clinical Center for Fallopian Tube Adenocarcinoma

Genetic Tests for Fallopian Tube Adenocarcinoma

Anatomical Context for Fallopian Tube Adenocarcinoma

MalaCards organs/tissues related to Fallopian Tube Adenocarcinoma:

41
Endothelial, Cervix, Ovary, Lung, Brain

Publications for Fallopian Tube Adenocarcinoma

Articles related to Fallopian Tube Adenocarcinoma:

(show all 19)
# Title Authors Year
1
Paraneoplastic cerebellar degeneration in a patient with a primary fallopian tube adenocarcinoma. A case report and brief review. ( 28386581 )
2017
2
Primary fallopian tube adenocarcinoma with brain and lung metastasis. ( 19805996 )
2009
3
Synchronous granulosa cell tumour of the ovary and fallopian tube adenocarcinoma: two rare gynaecological malignancies. ( 17116067 )
2006
4
Sister Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarcinoma. ( 16698532 )
2006
5
Paraneoplastic cerebellar degeneration with fallopian tube adenocarcinoma. ( 16126258 )
2005
6
Primary fallopian tube adenocarcinoma: preoperative diagnosis, treatment and follow-up. ( 15493187 )
2004
7
Superior vena cava syndrome during chemotherapy for stage 3c fallopian tube adenocarcinoma. ( 15047247 )
2004
8
Paraneoplastic cerebellar degeneration heralding fallopian tube adenocarcinoma. ( 11328418 )
2001
9
Outcome of advanced primary fallopian tube adenocarcinoma. ( 10575806 )
1999
10
Surgico-pathological stage I primary fallopian tube adenocarcinoma. ( 9849719 )
1998
11
Prognosis of primary fallopian tube adenocarcinoma: report of 25 patients. ( 10215444 )
1998
12
Splenic metastasis of a fallopian tube adenocarcinoma. ( 9830550 )
1998
13
p53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma. ( 8883398 )
1996
14
Primary fallopian tube adenocarcinoma: clinical complete response after salvage treatment with high-dose paclitaxel. ( 7622116 )
1995
15
Primary fallopian tube adenocarcinoma in situ associated with adjuvant tamoxifen therapy for breast carcinoma. ( 8157199 )
1994
16
Primary fallopian tube adenocarcinoma with metastasis to the uterine cervix. A case report. ( 8181486 )
1993
17
Primary fallopian tube adenocarcinoma presenting as a hydrosalpinx: CT appearance. ( 3392277 )
1988
18
Fallopian tube adenocarcinoma: common extraperitoneal recurrence. ( 3710267 )
1986
19
Obstructing intracolonic metastases secondary to fallopian tube adenocarcinoma. ( 7147990 )
1982

Variations for Fallopian Tube Adenocarcinoma

Expression for Fallopian Tube Adenocarcinoma

Search GEO for disease gene expression data for Fallopian Tube Adenocarcinoma.

Pathways for Fallopian Tube Adenocarcinoma

GO Terms for Fallopian Tube Adenocarcinoma

Cellular components related to Fallopian Tube Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.26 CALB2 MAPK8IP1 MME PTPRN
2 lateral element GO:0000800 8.62 BRCA1 BRCA2

Biological processes related to Fallopian Tube Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.86 BRCA1 BRCA2 ERBB2 INSM1 MAPK8IP1 MYOG
2 cell cycle GO:0007049 9.72 BRCA1 BRCA2 INSM1 MYOG TP53
3 response to gamma radiation GO:0010332 9.49 BRCA2 TP53
4 cell aging GO:0007569 9.48 BRCA2 TP53
5 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.46 BRCA2 TP53
6 strand displacement GO:0000732 9.43 BRCA1 BRCA2
7 response to X-ray GO:0010165 9.4 BRCA2 TP53
8 replicative senescence GO:0090399 9.37 MME TP53
9 chordate embryonic development GO:0043009 9.16 BRCA1 BRCA2
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.13 BRCA1 BRCA2 TP53
11 positive regulation of cell cycle arrest GO:0071158 8.92 BRCA1 INSM1 MYOG TP53

Sources for Fallopian Tube Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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