MCID: FLL028
MIFTS: 27

Fallopian Tube Carcinosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fallopian Tube Carcinosarcoma

MalaCards integrated aliases for Fallopian Tube Carcinosarcoma:

Name: Fallopian Tube Carcinosarcoma 12 15 17 70
Fallopian Tube Malignant Mixed Mesodermal Tumor 12
Fallopian Tube Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1970
NCIt 50 C40124
UMLS 70 C1517117

Summaries for Fallopian Tube Carcinosarcoma

Disease Ontology : 12 A fallopian tube cancer that is characterized as a mixture of carcinoma and sarcoma and has material basis in epithelial tissue and has material basis in connective tissue.

MalaCards based summary : Fallopian Tube Carcinosarcoma, also known as fallopian tube malignant mixed mesodermal tumor, is related to carcinosarcoma and fallopian tube adenosarcoma. An important gene associated with Fallopian Tube Carcinosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Glucocorticoid receptor regulatory network. The drugs Paclitaxel and Topotecan have been mentioned in the context of this disorder. Affiliated tissues include endothelial.

Related Diseases for Fallopian Tube Carcinosarcoma

Diseases related to Fallopian Tube Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 carcinosarcoma 30.2 TP53 CALB2
2 fallopian tube adenosarcoma 10.2 NCOA2 MEIS1
3 spindle cell sarcoma 10.1 NCOA2 MEIS1
4 rete testis adenoma 10.1 NCAM1 CALB2
5 adult type testicular granulosa cell tumor 10.1 NCAM1 CALB2
6 papillary thymic adenocarcinoma 10.1 NCAM1 CALB2
7 infected hydrocele 10.1 NCAM1 CALB2
8 adenofibroma 10.0 TP53 CALB2
9 clear cell cystadenofibroma 10.0 TP53 CALB2
10 non-gestational ovarian choriocarcinoma 10.0 TP53 NCAM1
11 laryngeal neuroendocrine tumor 10.0 TP53 NCAM1
12 biliary tract benign neoplasm 10.0 TP53 NCAM1
13 glomangiomatosis 10.0 TP53 NCAM1
14 urethral benign neoplasm 10.0 TP53 CALB2
15 malignant spiradenoma 10.0 TP53 CALB2
16 bile duct adenoma 10.0 TP53 NCAM1
17 keratocystic odontogenic tumor 10.0 TP53 CALB2
18 intrahepatic bile duct adenoma 10.0 TP53 NCAM1
19 small cell carcinoma 10.0 TP53 NCAM1
20 pleomorphic carcinoma 10.0 TP53 CALB2
21 mixed cell type cancer 10.0 TP53 CALB2
22 glomus tumor 10.0 TP53 CALB2
23 cystic teratoma 10.0 TP53 CALB2
24 connective tissue benign neoplasm 10.0 TP53 CALB2
25 ovarian cystadenocarcinoma 9.9 TP53 CALB2
26 reproductive organ benign neoplasm 9.9 TP53 CALB2
27 monoclonal gammopathy of uncertain significance 9.9 TP53 NCAM1
28 thymic carcinoma 9.9 TP53 CALB2
29 mature t-cell and nk-cell lymphoma 9.9 TP53 NCAM1
30 testicular granulosa cell tumor 9.9 WT1 CALB2
31 epididymal neoplasm 9.9 WT1 CALB2
32 lung benign neoplasm 9.9 TP53 NCAM1
33 ovarian large-cell neuroendocrine carcinoma 9.9 WT1 NCAM1
34 testicular fibroma 9.9 WT1 CALB2
35 wolffian duct adenocarcinoma 9.9 WT1 CALB2
36 pericardium cancer 9.9 WT1 CALB2
37 malignant biphasic mesothelioma 9.9 WT1 CALB2
38 ovarian endometrioid stromal sarcoma 9.9 WT1 CALB2
39 juvenile type testicular granulosa cell tumor 9.9 WT1 CALB2
40 ovarian gonadoblastoma 9.9 WT1 CALB2
41 liver leiomyosarcoma 9.9 WT1 CALB2
42 endosalpingiosis 9.9 WT1 CALB2
43 ovarian sex-cord stromal tumor 9.9 WT1 CALB2
44 epididymis adenocarcinoma 9.9 WT1 CALB2
45 epididymis cancer 9.9 WT1 CALB2
46 ameloblastoma 9.9 TP53 CALB2
47 epithelioid cell synovial sarcoma 9.9 WT1 CALB2
48 ovary sarcoma 9.9 WT1 CALB2
49 benign peritoneal mesothelioma 9.9 WT1 CALB2
50 peritoneal mesothelioma 9.9 WT1 CALB2

Graphical network of the top 20 diseases related to Fallopian Tube Carcinosarcoma:



Diseases related to Fallopian Tube Carcinosarcoma

Symptoms & Phenotypes for Fallopian Tube Carcinosarcoma

Drugs & Therapeutics for Fallopian Tube Carcinosarcoma

Drugs for Fallopian Tube Carcinosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6
Iodine Approved, Investigational Phase 2 7553-56-2 807
7 Angiogenesis Inhibitors Phase 2
8 Tubulin Modulators Phase 2
9 Antibiotics, Antitubercular Phase 2
10 topoisomerase I inhibitors Phase 2
11
Liposomal doxorubicin Phase 2 31703
12 Mitogens Phase 2
13 Antimitotic Agents Phase 2
14 Antibodies Phase 2
15 Antineoplastic Agents, Immunological Phase 2
16 Immunoglobulins, Intravenous Phase 2
17 Immunoglobulin G Phase 2
18 Immunoglobulins Phase 2
19 Immunosuppressive Agents Phase 2
20 Albumin-Bound Paclitaxel Phase 2
21 Immunologic Factors Phase 2
22 Antiviral Agents Phase 2
23 Antimetabolites Phase 2
24 Antibodies, Monoclonal Phase 2
25 Endothelial Growth Factors Phase 2
26 Anti-Infective Agents Phase 2
27 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MC1365, A Randomized Phase II Trial of a Genetically Engineered NIS-Expressing Strain of Measles Virus Versus Investigator's Choice Chemotherapy for Patients With Platinum-Resistant Ovarian, Fallopian, or Peritoneal Cancer Recruiting NCT02364713 Phase 2 Gemcitabine Hydrochloride;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride;Topotecan Hydrochloride

Search NIH Clinical Center for Fallopian Tube Carcinosarcoma

Genetic Tests for Fallopian Tube Carcinosarcoma

Anatomical Context for Fallopian Tube Carcinosarcoma

MalaCards organs/tissues related to Fallopian Tube Carcinosarcoma:

40
Endothelial

Publications for Fallopian Tube Carcinosarcoma

Articles related to Fallopian Tube Carcinosarcoma:

# Title Authors PMID Year
1
Investigation of the clinicopathological features of fallopian tube malignancy. 61
23633088 2013
2
Carcinosarcoma of the fallopian tube. 61
2537783 1989
3
[Contribution to the study of malignant mixed tumors of the Fallopian tube (carcinosarcoma)]. 61
13808558 1959

Variations for Fallopian Tube Carcinosarcoma

Expression for Fallopian Tube Carcinosarcoma

Search GEO for disease gene expression data for Fallopian Tube Carcinosarcoma.

Pathways for Fallopian Tube Carcinosarcoma

Pathways related to Fallopian Tube Carcinosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 WT1 TP53 MEIS1
2 10.87 TP53 NCOA2

GO Terms for Fallopian Tube Carcinosarcoma

Cellular components related to Fallopian Tube Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.92 WT1 TP53 NCOA2 MEIS1

Biological processes related to Fallopian Tube Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.56 WT1 TP53 NCOA2 MEIS1
2 circadian rhythm GO:0007623 9.32 TP53 NCOA2
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.26 WT1 TP53 NCOA2 MEIS1
4 interferon-gamma-mediated signaling pathway GO:0060333 9.16 TP53 NCAM1
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 WT1 TP53

Molecular functions related to Fallopian Tube Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.33 TP53 NCOA2 MEIS1
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.13 WT1 TP53 MEIS1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.92 WT1 TP53 NCOA2 MEIS1

Sources for Fallopian Tube Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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